Alberto Pinsino, Matteo Fabbri, Lorenzo Braghieri, Bruno Bohn, Antonia J Gaudig, Andrea Kim, Koji Takeda, Yoshifumi Naka, Gabriel T Sayer, Nir Uriel, Ryan T Demmer, Robert T Faillace, Syed A Husain, Sumit Mohan, Paolo C Colombo, Melana Yuzefpolskaya
AIMS: Acute heart failure (HF) is associated with muscle mass loss, potentially leading to overestimation of kidney function using serum creatinine-based estimated glomerular filtration rate (eGFRsCr ). Cystatin C-based eGFR (eGFRCysC ) is less muscle mass dependent. Changes in the difference between eGFRCysC and eGFRsCr may reflect muscle mass loss. We investigated the difference between eGFRCysC and eGFRsCr and its association with clinical outcomes in acute HF patients. METHODS AND RESULTS: A post hoc analysis was performed in 841 patients enrolled in three trials: Diuretic Optimization Strategy Evaluation (DOSE), Renal Optimization Strategies Evaluation (ROSE), and Cardiorenal Rescue Study in Acute Decompensated Heart Failure (CARRESS-HF)...
June 27, 2022: ESC Heart Failure