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https://read.qxmd.com/read/38467465/histopathology-of-congestive-nephropathy-a-case-description-and-literature-review
#1
Faeq Husain-Syed, Janani Rangaswami, Julio Núñez, Susanne Skrzypek, Christian Jux, Hermann-Josef Gröne, Horst-Walter Birk
Congestive nephropathy is an underappreciated manifestation of cardiorenal syndrome and is characterized by a potentially reversible kidney dysfunction caused by a reduced renal venous outflow secondary to right-sided heart failure or intra-abdominal hypertension. To date, the histological diagnostic criteria for congestive nephropathy have not been defined. We herein report a case of acute renal dysfunction following cardiac allograft failure and present a review of the relevant literature to elucidate the current understanding of the disease...
March 11, 2024: ESC Heart Failure
https://read.qxmd.com/read/38171343/mechanistic-links-between-central-obesity-and-cardiorenal-metabolic-diseases
#2
REVIEW
Saif Al-Chalabi, Akheel A Syed, Philip A Kalra, Smeeta Sinha
Background There has been a marked increase in the global prevalence of obesity over recent decades with an estimated 1.9 billion adults who are overweight or living with obesity. This is associated with a sharp rise in the prevalence of cardiorenal metabolic diseases such as type 2 diabetes mellitus, chronic kidney disease, and heart failure. Given recent evidence of the efficacy of sodium glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists on cardiorenal protection and weight reduction, it is reasonable to investigate common causative pathways for cardiorenal metabolic diseases...
January 3, 2024: Cardiorenal Medicine
https://read.qxmd.com/read/38166049/real-world-evaluation-of-care-for-type-2-diabetes-in-malaysia-a-cross-sectional-analysis-of-the-treatment-adherence-to-guideline-evaluation-in-type-2-diabetes-target-t2d-study
#3
JOURNAL ARTICLE
Lee-Ling Lim, Zanariah Hussein, Nurain Md Noor, Anis S Abd Raof, Norlaila Mustafa, Mohamed B Long Bidin, Rohana Abdul Ghani, Syahrizan Samsuddin, Sy-Liang Yong, Siew-Hui Foo, Kavitha Raghuram, Payiarat Suwannasri, Wan Mohamad W B, Thiam-Kian Chiew, Siew-Pheng Chan
AIM: Given a lack of data on diabetes care performance in Malaysia, we conducted a cross-sectional study to understand the clinical characteristics, control of cardiometabolic risk factors, and patterns of use of guideline-directed medical therapy (GDMT) among patients with type 2 diabetes (T2D), who were managed at publicly-funded hospitals between December 2021 and June 2022. METHODS: Patients aged ≥18 years with T2D from eight publicly-funded hospitals in the Greater Kuala Lumpur region, who had ≥2 outpatient visits within the preceding year and irrespective of treatment regimen, were eligible...
2024: PloS One
https://read.qxmd.com/read/37811017/efficacy-and-safety-of-finerenone-in-chronic-kidney-disease-and-type-2-diabetes-patients-a-systematic-review-and-meta-analysis
#4
REVIEW
Farah Yasmin, Muhammad Aamir, Hala Najeeb, Abdul Raafe Atif, Abdul Hannan Siddiqui, Muhammad Nadeem Ahsan, Abdul Moeed, Syed Hasan Ali, Haya Muhammad Tahir, Muhammad Sohaib Asghar
BACKGROUND AND OBJECTIVES: The incidence of morbidity and mortality in patients with type 2 diabetes mellitus is substantially correlated with cardiovascular disease and chronic kidney disease. The current guidelines recommend the use of renin-angiotensin system blockers, but recent studies probed into the effects of finerenone to mitigate the risk of cardiorenal events. This meta-analysis was performed to demonstrate the effects of finerenone on cardiorenal events, comprising cardiovascular mortality, heart failure, change in estimated glomerular filtration rate, and serum potassium levels...
October 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/37664568/associations-between-egfr-and-albuminuria-with-right-ventricular-measures-the-mesa-right-ventricle-study
#5
JOURNAL ARTICLE
Faeq Husain-Syed, Matthew F DiFrancesco, Rajat Deo, R Graham Barr, Julia J Scialla, David A Bluemke, Richard A Kronmal, Joao A C Lima, Amy Praestgaard, Russell P Tracy, Michael Shlipak, Steven M Kawut, John S Kim
BACKGROUND: Chronic kidney disease (CKD) is associated with an increased risk of pulmonary hypertension, which may lead to right ventricular (RV) pressure overload and RV dysfunction. However, the presence of subclinical changes in RV structure or function in early CKD and the influence of these changes on mortality are not well studied. We hypothesized that early CKD, as indicated by elevated albuminuria or mild reductions in estimated glomerular filtration rate (eGFR), is associated with greater RV dilation and RV mass...
September 2023: Clinical Kidney Journal
https://read.qxmd.com/read/37577933/changes-in-doppler-derived-kidney-venous-flow-and-adverse-cardiorenal-outcomes-in-patients-with-heart-failure
#6
JOURNAL ARTICLE
Faeq Husain-Syed, Narayana Sarma V Singam, Jason K Viehman, Lisa Vaughan, Pascal Bauer, Henning Gall, Khodr Tello, Manuel J Richter, Athiththan Yogeswaran, Gregorio Romero-González, Mitchell H Rosner, Claudio Ronco, Birgit Assmus, Hossein Ardeschir Ghofrani, Werner Seeger, Horst-Walter Birk, Kianoush B Kashani
Background The impact of changes in Doppler-derived kidney venous flow in heart failure (HF) is not well studied. We aimed to investigate the association of Doppler-derived kidney venous stasis index (KVSI) and intrakidney venous-flow (IKVF) patterns with adverse cardiorenal outcomes in patients with HF. Methods and Results In this observational cohort study, consecutive inpatients with HF referred to a nephrologist because of a history of diuretic resistance and abnormal kidney function (n=216) underwent spectral kidney assessments after admission (Doppler 1) and 25 to 35 days later (Doppler 2) to identify IKVF patterns (continuous/pulsatile/biphasic/monophasic) and KVSI levels...
August 14, 2023: Journal of the American Heart Association
https://read.qxmd.com/read/37234373/estimated-plasma-volume-status-association-with-congestion-cardiorenal-syndrome-and-prognosis-in-precapillary-pulmonary-hypertension
#7
JOURNAL ARTICLE
Athiththan Yogeswaran, Manuel J Richter, Faeq Husain-Syed, Zvonimir Rako, Natascha Sommer, Friedrich Grimminger, Werner Seeger, Hossein Ardeschir Ghofrani, Henning Gall, Khodr Tello
BACKGROUND: Volume overload is often associated with clinical deterioration in precapillary pulmonary hypertension (PH). However, thorough assessment of volume overload is complex and therefore not routinely performed. We examined whether estimated plasma volume status (ePVS) is associated with central venous congestion and prognosis in patients with idiopathic pulmonary arterial hypertension (IPAH) or chronic thromboembolic PH (CTEPH). METHODS: We included all patients with incident IPAH or CTEPH enrolled in the Giessen PH Registry between January 2010 and January 2021...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/37183423/type-2-diabetes-treatment-recommendations-for-reducing-the-risk-of-complications
#8
JOURNAL ARTICLE
Hannah Syed
Nurses should recognise type 2 diabetes as a cardiorenal metabolic syndrome that requires the holistic management of blood glucose, blood pressure, lipid levels and lifestyle factors. It is also important that nurses can identify, prevent and manage complications associated with type 2 diabetes, such as cardiovascular disease, retinopathy, nephropathy, foot health issues and psychological effects. This article explains the latest national guidelines on managing type 2 diabetes in adults, including the recommendations for pharmacological treatment, thereby supporting nurses to provide effective care for people with this condition...
May 15, 2023: Nursing Standard
https://read.qxmd.com/read/35762103/the-difference-between-cystatin-c-and-creatinine-based-assessment-of-kidney-function-in-acute-heart-failure
#9
JOURNAL ARTICLE
Alberto Pinsino, Matteo Fabbri, Lorenzo Braghieri, Bruno Bohn, Antonia J Gaudig, Andrea Kim, Koji Takeda, Yoshifumi Naka, Gabriel T Sayer, Nir Uriel, Ryan T Demmer, Robert T Faillace, Syed A Husain, Sumit Mohan, Paolo C Colombo, Melana Yuzefpolskaya
AIMS: Acute heart failure (HF) is associated with muscle mass loss, potentially leading to overestimation of kidney function using serum creatinine-based estimated glomerular filtration rate (eGFRsCr ). Cystatin C-based eGFR (eGFRCysC ) is less muscle mass dependent. Changes in the difference between eGFRCysC and eGFRsCr may reflect muscle mass loss. We investigated the difference between eGFRCysC and eGFRsCr and its association with clinical outcomes in acute HF patients. METHODS AND RESULTS: A post hoc analysis was performed in 841 patients enrolled in three trials: Diuretic Optimization Strategy Evaluation (DOSE), Renal Optimization Strategies Evaluation (ROSE), and Cardiorenal Rescue Study in Acute Decompensated Heart Failure (CARRESS-HF)...
June 27, 2022: ESC Heart Failure
https://read.qxmd.com/read/35359461/cardiorenal-disease-in-covid-19-patients
#10
REVIEW
Muhtasham Sifaat, Pinak Patel, Razan Sheikh, Dawood Ghaffar, Hitesh Vaishnav, Ludmila Nahar, Sonia Rupani, Syed Quadri
Coronavirus disease 2019 (COVID-19) is an illness caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Mutations in the genetic coding and the variations in the spike proteins are critical for the virus's mechanism of facilitating fusion with the human host, making the disease more severe. Recent research indicates that comorbidities including diabetes, hypertension, renal disease, heart failure, and atherosclerosis play a significant role in the severity and high mortality rates of (COVID-19), suggesting that perhaps the metabolic syndrome and its components are associated with COVID-19 morbidity...
2022: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://read.qxmd.com/read/34513443/sodium-glucose-cotransporter-2-sglt-2-inhibitors-delving-into-the-potential-benefits-of-cardiorenal-protection-beyond-the-treatment-of-type-2-diabetes-mellitus
#11
REVIEW
Natasha Srinivas, Mubashira K Sarnaik, Srimy Modi, Yasaswi Pisipati, Sarayoo Vaidya, Naqvi Syed Gaggatur, Aliya H Sange, Ibrahim Sange
Diabetes mellitus is a leading cause of morbidity and mortality and a significant risk factor for the early onset of chronic kidney disease and heart disease. Hyperglycemia and insulin resistance are key factors that play a role in the pathogenesis of type 2 diabetes. Renal glucose reabsorption is a critical component of glycemic regulation. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, commonly known as gliflozins, lower blood sugar levels by inhibiting glucose absorption in the proximal tubule of the kidney...
August 2021: Curēus
https://read.qxmd.com/read/34091459/ultrasonographic-assessment-of-extravascular-lung-water-in-hospitalized-patients-requiring-hemodialysis-a-prospective-observational-study
#12
JOURNAL ARTICLE
Jing Miao, Janina Paula T Sy-Go, Meltiady Issa, Hussam Jenad, Sandhya Manohar, Ziad Zoghby, Kianoush B Kashani, James R Gregoire
INTRODUCTION: Sonographic technologies can estimate extravascular lung water (EVLW) in hemodialysis (HD) patients. This study investigated the suitability of a handheld scanner in contrast to a portable scanner for quantifying EVLW in hospitalized patients requiring HD. METHODS: In this prospective study, 54 hospitalized HD patients were enrolled. Bedside lung ultrasound was performed within 30 min before and after dialysis using handheld (phased array transducer, 1...
2021: Cardiorenal Medicine
https://read.qxmd.com/read/33258308/congestive-nephropathy-a-neglected-entity-proposal-for-diagnostic-criteria-and-future-perspectives
#13
REVIEW
Faeq Husain-Syed, Hermann-Josef Gröne, Birgit Assmus, Pascal Bauer, Henning Gall, Werner Seeger, Ardeschir Ghofrani, Claudio Ronco, Horst-Walter Birk
Venous congestion has emerged as an important cause of renal dysfunction in patients with cardiorenal syndrome. However, only limited progress has been made in differentiating this haemodynamic phenotype of renal dysfunction, because of a significant overlap with pre-existing renal impairment due to long-term hypertension, diabetes, and renovascular disease. We propose congestive nephropathy (CN) as this neglected clinical entity. CN is a potentially reversible subtype of renal dysfunction associated with declining renal venous outflow and progressively increasing renal interstitial pressure...
February 2021: ESC Heart Failure
https://read.qxmd.com/read/31912717/alterations-in-doppler-derived-renal-venous-stasis-index-during-recompensation-of-right-heart-failure-and-fluid-overload-in-a-patient-with-pulmonary-hypertension
#14
JOURNAL ARTICLE
Faeq Husain-Syed, Horst-Walter Birk, Khodr Tello, Manuel J Richter, Claudio Ronco, Peter A McCullough, Tanja Schörmann, Fiorenza Ferrari, Gökhan Yücel, Babak Yazdani, Hans-Dieter Walmrath, Werner Seeger, Henning Gall, H Ardeschir Ghofrani
Renal congestion is becoming recognized as a potential contributor to cardiorenal syndromes. Adequate control of congestion with simultaneous preservation of renal function has been proposed as a central goal of the management of heart failure. We report our care of a 48-year-old woman suffering from right heart failure and massive fluid overload due to severe pulmonary hypertension secondary to a combination of left-heart disease and status after recurrent pulmonary embolisms. Alterations in Doppler-derived intrarenal venous flow patterns and a novel renal venous stasis index were used to evaluate improvement in renal venous congestion during recompensation...
December 30, 2019: Reviews in Cardiovascular Medicine
https://read.qxmd.com/read/26436367/peritoneal-ultrafiltration-for-refractory-fluid-overload-and-ascites-due-to-pulmonary-arterial-hypertension
#15
JOURNAL ARTICLE
Faeq Husain-Syed, María-Jimena Muciño-Bermejo, Claudio Ronco, Werner Seeger, Horst-Walter Birk
Pulmonary hypertension is a common finding in patients with advanced liver disease. Similarly, among patients with advanced pulmonary arterial hypertension, right heart failure leads to congestive hepatopathy. Diuretic resistant fluid overload in both advanced pulmonary hypertension and chronic liver disease is a demanding challenge for physicians. Venous congestion and ascites-induced increased intra-abdominal pressure are essential regarding recurrent hospitalization, morbidity and mortality. Due to impaired right-ventricular function, many patients cannot tolerate extracorporeal ultrafiltration...
November 2015: Annals of Hepatology
https://read.qxmd.com/read/22258398/an-emerging-role-for-understanding-orthostatic-hyp-er-tension-in-the-cardiorenal-syndrome
#16
JOURNAL ARTICLE
Jaya P Buddineni, Laxmi Chauhan, Syed T Ahsan, Adam Whaley-Connell
Orthostatic hypertension (OHT) is a clinically important problem increasingly recognized in persons with borderline hypertension, diabetes mellitus, and autonomic neuropathies, and in the elderly. Moreover, the association of OHT with progression of target end-organ damage, especially coronary heart disease and chronic kidney disease (CKD), and the attendant increased cardiovascular disease (CVD) and CKD risk, is gaining attention but is still underappreciated. There are various mechanisms that contribute to the development of OHT: excessive vascular adrenergic sensitivity, baroreceptor reflex abnormalities, and inappropriate activation of the renin-angiotensin-aldosterone system, which are also mechanisms that lead to cardiorenal metabolic disease (CRS)...
2011: Cardiorenal Medicine
https://read.qxmd.com/read/18765078/anemia-and-the-potential-role-of-erythropoiesis-stimulating-agents-in-heart-failure
#17
REVIEW
Haroon A Faraz, Syed F Zafar, Jalal K Ghali
The recognition of the high prevalence and the independent prognostic role of anemia in heart failure (HF) has contributed to intensification of the search for an effective treatment. A central role of erythropoietin in cardiorenal anemia syndrome has been proposed. Several clinical trials have established the safety and efficacy of erythropoiesis-stimulating agents in correcting anemia in patients with HF. The recognition of the pleiotropic effect of erythropoietin has expanded targets of therapy. The ongoing outcomes trial with darbepoetin alfa will determine the role of this novel therapy in the treatment of HF...
June 2008: Current Heart Failure Reports
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