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https://www.readbyqxmd.com/read/28816073/overactive-bladder-treatment-application-of-methylene-blue-to-improve-the-injection-technique-of-onabotulinum-toxin-a
#1
Michał Szczypior, Wojciech Połom, Marcin Markuszewski, Krzesimir Ciura, Magdalena Buszewska-Forajta, Julia Jacyna, Michał Markuszewski, Marcin Matuszewski
OBJECTIVE: The aim of this study was to test the addition of methylene blue (MB) to onabotulinum toxin A (BTX-A) solution in overactive bladder (OAB) treatment, as a means of facilitating observation of the injection site and assessing the distribution of the drug under the bladder mucosa during injection. Pharmacological interactions between BTX-A and MB were also evaluated. MATERIALS AND METHODS: The study was conducted between December 2014 and April 2016 on 30 patients: six males and 24 females (median age 57...
August 17, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28808734/what-is-the-true-catheterization-rate-after-intravesical-onabotulinumtoxina-injection
#2
Devin N Patel, Juzar Jamnagerwalla, Justin Houman, Jennifer T Anger, Karyn S Eilber
INTRODUCTION AND HYPOTHESIS: A known side effect of intravesical onabotulinumtoxinA (Botox®) injection for overactive bladder (OAB) is urinary retention requiring clean intermittent catheterization (CIC), the fear of which deters patients from choosing this therapy. In clinical practice, patients with an elevated postvoid residual (PVR) are often managed by observation only, providing they do not have subjective complaints or contraindications. We sought to determine the true rate of urinary retention requiring CIC in clinical practice...
August 14, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28808621/von-brunn-s-nests-and-follicular-cystitis-following-intradetrusor-onabotulinumtoxina-injections-for-overactive-bladder
#3
Silpa Nekkanti, Andrew Doering, Debra L Zynger, Andrew F Hundley
A 67-year-old female with refractory OAB was treated with intradetrusor Botox. She subsequently developed multiple papillary bladder lesions with tissue biopsy showing Von Brunn's nests. Von Brunn's nests are benign bladder lesions similar in appearance to a rare urothelial tumor called Nested Variant of Urothelial Carcinoma (NVUC). It is critical that patients with these findings undergo evaluation to rule out the presence of carcinoma. This finding suggests the possibility of a previously unreported adverse reaction in association with intradetrusor Botox...
September 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28805473/the-impact-of-persistence-with-mirabegron-usage-versus-switching-to-onabotulinumtoxina-on-healthcare-costs-and-resource-utilization-in-patients-with-overactive-bladder-in-the-united-states
#4
Daniel Bin Ng, Robert Espinosa, Scott J Johnson, David Walker, Katherine Gooch
Aims To compare healthcare costs and resource utilization in patients with overactive bladder (OAB) in the United States who switch from mirabegron to onabotulinumtoxinA (onabotA) with those who persist on mirabegron. Materials and methods A retrospective observational claims analysis of the OptumHealth Administrative Claims database conducted between April 1, 2012 and September 30, 2015 used medical and pharmacy claims to identify patients with at least one OAB diagnosis who switched from mirabegron to onabotA (onabotA group) or persisted on mirabegron for at least 180 days (mirabegron persisters)...
August 14, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28803902/association-between-irritable-bowel-syndrome-and-overactive-bladder-a-research-survey
#5
Kyu Shik Kim, Hyung-Jee Kim, Seong Ho Lee, Sung Tae Cho, Hong Sang Moon
OBJECTIVE: To investigated the relationship between irritable bowel syndrome (IBS) and overactive bladder (OAB) in men and women using questionnaires. MATERIAL AND METHODS: This research survey was based on multi-center data (men and women older than 20 years). The Korean version of the Rome III criteria was used for the diagnosis of IBS, overactive bladder symptom score (OABSS) was used for screening OAB, Self-Rating Depression Scale (SDS) was used for depressive symptoms, and International Prostate Symptom Score & Quality of Life (IPSS & QoL) were used to determine the degrees of lower urinary tract symptoms...
August 10, 2017: Urology
https://www.readbyqxmd.com/read/28802769/electrophysiological-correlates-of-voice-memory-for-young-and-old-speakers-in-young-and-old-listeners
#6
Romi Zäske, Katharina Limbach, Dana Schneider, Verena G Skuk, Christian Dobel, Orlando Guntinas-Lichius, Stefan Robert Schweinberger
Faces of one's own-age group are easier to recognize than other-age faces. Using behavioural measures and EEG, we studied whether an own-age bias (OAB) also exists in voice memory. Young (19 - 26 years) and old (60 - 75 years) participants studied young (18 - 25 years) and old (60 - 77 years) unfamiliar voices from short sentences. Subsequently, they classified studied and novel voices as "old" (i.e. studied) or "new", from the same sentences. Recognition performance was higher in young compared to old participants, and for old compared to young voices, with no OAB...
August 9, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28792105/transcutaneous-posterior-tibial-nerve-electrostimulation-with-low-dose-trospium-chloride-could-it-be-used-as-a-second-line-treatment-of-overactive-bladder-in-females
#7
Amr Abulseoud, Ahmed Moussa, Gaber Abdelfattah, Ibrahim Ibrahim, Emmanuel Saba, Mohamed Hassouna
AIM: To evaluate the effect of adding low dose trospium chloride with transcutaneous posterior tibial nerve stimulation (TPTNS) in the treatment of overactive bladder (OAB) in females after failure of behavioral therapy. METHODS: We randomized 30 women with OAB, in two groups: G I received 30 min TPTNS, three times a week; GII received TPTNS plus 20 mg trospium chloride daily. OAB Symptom Score questionnaire (OABSS), Incontinence Impact Questionnaire-short form 7 (IIQ-7), 3 day voiding diary and urodynamics at weeks 0 and 8 were evaluated...
August 9, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28791238/the-underactive-bladder-diagnosis-and-surgical-treatment-options
#8
REVIEW
Johan Gani, Derek Hennessey
The underactive bladder (UAB)/detrusor underactivity (DU) is a relatively common condition. It is difficult to diagnose and can be difficult to manage. The aim of this review is to provide a review of the diagnosis and different surgical treatment options for UAB/DU. A comprehensive literature review using medical search engines was performed. The search included a combination of the following terms, UAB, DU, TURP, reduction cystoplasty, bladder diverticulectomy and sacral neuromodulation (SNM). Search results were assessed for their overall relevance to this review...
July 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28780649/de-novo-overactive-bladder-following-midurethral-sling-procedures-a-systematic-review-of-the-literature-and-meta-analysis
#9
REVIEW
Vasilios Pergialiotis, Zini Mudiaga, Despina N Perrea, Stergios K Doumouchtsis
INTRODUCTION AND HYPOTHESIS: De novo overactive bladder (OAB) is a known complication of midurethral sling surgery for the treatment of stress urinary incontinence. To date, differences in the incidence of de novo OAB following the use of different types of midurethral sling remain relatively unknown. The purpose of the present systematic review was to evaluate this incidence and summarize current evidence. METHODS: We systematically searched the literature using the MEDLINE, Embase, Scopus, ClinicalTrials...
August 5, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28776345/influence-of-daytime-or-nighttime-dosing-with-solifenacin-for-overactive-bladder-with-nocturia-impact-on-nocturia-and-sleep-quality
#10
Taekmin Kwon, Tae Hee Oh, Seong Choi, Won Yeol Cho, Kweonsik Min, Jeong Zoo Lee, Kyung Hyun Moon
We compared changes in nocturia and sleep-related parameters between daytime and nighttime solifenacin dosing in patents with overactive bladder (OAB) and nocturia. We comparatively analyzed the data of a 12-week prospective, open-label, multicenter, randomized study. All 127 patients who presented to 5 centers in Korea for the treatment of OAB with nocturia between January 2011 and December 2013 were enrolled in this study. The patients were divided into 2 groups by medication timing: group 1, daytime (n = 62); and group 2, nighttime (n = 65)...
September 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28768666/oab-without-an-overactive-bladder-in-the-acute-prostaglandin-e2-rat-model
#11
James A Hokanson, Christopher L Langdale, Arun Sridhar, Warren M Grill
Intravesical Prostaglandin E2 (PGE2) was previously used to induce overactive bladder (OAB) symptoms as it reduces bladder capacity in rats and causes a "strong urgency sensation" in healthy women. However, the mechanism by which this occurs is unclear. To clarify how PGE2 reduces bladder capacity, 100 µM PGE2 was administered intravesically during open, single-fill cystometry with simultaneous measurement of sphincter EMG in the urethane-anesthetized female Wistar rat. PGE2 was also applied to the urethra or bladder selectively by use of a ligature at the bladder neck prior to (urethra) or during (bladder) closed-outlet, single-fill cystometry...
August 2, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28763112/systematic-literature-review-of-clinical-trials-evaluating-pharmacotherapy-for-overactive-bladder-in-elderly-patients-an-assessment-of-trial-quality
#12
REVIEW
Kristin D Kistler, Yingxin Xu, Kelly H Zou, Fady Ntanios, Douglass S Chapman, Xuemei Luo
AIMS: Overactive bladder (OAB) disproportionately affects older-aged adults, yet most randomized controlled trials (RCTs) underrepresent patients ≥65. This systematic literature review (SLR) identified RCTs evaluating β-3 adrenergic agonists or muscarinic antagonists in elderly patients with OAB, and compared study quality across trials. METHODS: MEDLINE(®) , Embase(®) , and Cochrane Collaboration Central Register of Clinical Trials databases were searched from inception through April 28, 2015 to identify published, peer-reviewed RCT reports evaluating β-3 adrenergic agonists or muscarinic antagonists in elderly OAB patients (either ≥65 years or study-described as "elderly")...
August 1, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28762672/safety-efficacy-and-persistence-of-long-term-mirabegron-treatment-for-overactive-bladder-in-the-daily-clinical-setting-interim-1-year-report-from-a-japanese-post-marketing-surveillance-study
#13
Daisuke Kato, Hiromi Tabuchi, Satoshi Uno
OBJECTIVES: To report interim 1-year results from a 3-year surveillance study evaluating safety, efficacy, and persistence of long-term mirabegron for overactive bladder (OAB). METHODS: Patients starting treatment with mirabegron for urinary urgency, daytime frequency, and urgency incontinence associated with OAB were registered and followed up for 3 years. Data were collected on adverse drug reactions (ADR), changes in OAB symptoms, changes in Overactive Bladder Symptom Score (OABSS), and treatment discontinuations...
August 1, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28762631/prevalence-and-risk-factors-of-urinary-incontinence-and-overactive-bladder-in-japanese-women
#14
Sanae Ninomiya, Kiyoko Naito, Kyoko Nakanishi, Hisayo Okayama
OBJECTIVES: The prevalence of storage symptoms, including stress urinary incontinence (SUI) and overactive bladder (OAB), is high in women worldwide. In Japan, there have been few large-scale epidemiological surveys of lower urinary tract symptoms (LUTS), and the risk factors for these symptoms are unclear. The aim of this study was to explore the prevalence and risk factors of storage symptoms in Japanese women. METHODS: A cross-sectional Internet survey was conducted in Japan...
August 1, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28762549/patient-targeted-websites-on-overactive-bladder-what-are-our-patients-reading
#15
Aisling A Clancy, Duane Hickling, Laura Didomizio, May Sanaee, Fady Shehata, Rebekah Zee, Hisham Khalil
AIMS: Patients often turn to the Internet for information on medical conditions. We sought to evaluate the quality and readability of highly visible websites on overactive bladder (OAB). METHODS: A survey of 42 consecutive patients attending outpatient urogynecology clinics was performed to identify the most commonly used Internet search engines and search terms for information on OAB. The three most commonly used search engines (Google, Bing, and Yahoo!) were then queried using the three most commonly used search terms...
August 1, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28762544/coexisting-depressive-symptoms-do-not-limit-the-benefits-of-chronic-neuromodulation-a-study-of-over-200-patients
#16
Kim A Killinger, Jonathan Fergus, Luke Edwards, Judith A Boura, Jamie Bartley, Priyanka Gupta, Janice Tomakowsky, Jason Gilleran, Kenneth M Peters
AIMS: To examine the relationship between coexisting depressive symptoms and outcomes after staged neuromodulation procedures for refractory urological symptoms. METHODS: Adults who enrolled in a prospective database and completed a Personal Health Questionnaire Depression Scale (PHQ-8) at baseline were reviewed. The PHQ-8 and Generalized Anxiety Disorder (GAD-7) assessed depressive/anxiety symptoms pre and 6 months post device implant. Urological symptoms were assessed with The Interstitial Cystitis Symptom Index/Problem Index (ICSI-PI) and Overactive Bladder Questionnaire (OAB-q) at baseline, 3 and 6 months, and Global Response Assessments (GRA) post implant...
August 1, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28758802/characteristics-of-antimuscarinic-responders-versus-suboptimal-responders-in-a-randomized-clinical-trial-of-patients-with-overactive-bladder-symptoms
#17
Lars Grenabo, Sender Herschorn, Steven A Kaplan, Linda Cardozo, David Scholfield, Daniel Arumi, Martin Carlsson, Douglass Chapman, Fady Ntanios
OBJECTIVE: To assess the characteristics of tolterodine extended-release (ER) 4 mg responders and suboptimal responders (≤50% decrease in UUI episodes/24 h) among patients with overactive bladder (OAB), including urgency urinary incontinence (UUI), and identify predictors of a >50% UUI response with fesoterodine 8 mg in tolterodine suboptimal responders. METHODS: Adult patients with OAB symptoms for ≥6 months and ≥8 micturitions, and ≥2 and <15 UUI episodes/24 h at week -2 received open-label tolterodine ER 4 mg during a 2-week run-in...
July 31, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28757173/are-patients-with-bladder-oversensitivity-different-from-those-with-urodynamically-proven-detrusor-overactivity-in-female-overactive-bladder-syndrome
#18
Sung-Lang Chen, Soo-Cheen Ng, Yu-Hui Huang, Gin-Den Chen
BACKGROUND: To determine if there are clinical and urodynamic (UD) differences between female overactive bladder (OAB) patients with bladder oversensitivity (BO) and detrusor overactivity (DO) via a much lower filling rate. METHODS: In total, 205 patients with OAB symptoms were recruited for this study. During filling cystometry, the bladder was filled at a more "physiological" rate of 20 ml/min. All patients underwent a complete urogynecological evaluation including detailed history, physical examination, urinalysis, pad test for quantification of urine leakage, 3-day frequency-volume chart (FVC) documentation, and completion of a UD study...
July 27, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28751103/-prevalence-and-characterization-of-overactive-bladder-detected-in-a-population-in-madrid-with-self-administered-oab-v3-questionnaire-in-primary-care
#19
Javier C Angulo, María P Calderín, Yolanda Fernández, Miriam González, Esther Gómez, Maria B Herreros, Purificación Peñasco, Manuela Zapatero, Juan F Dorado
OBJECTIVE: Determining the prevalence of symptoms suggestive of overactive bladder (OAB) in a Spanish population and evaluate the impact of these symptoms on well-being and labour productivity in this population. DESIGN: Transversal study. LOCATION: Primary health care, Madrid, Spain. PARTICIPANTS: Males and females >30 years. INTERVENTIONS: Classification by primary care physicians with the Overactive Bladder Awareness Tool abbreviated version (OAB-V3)...
July 24, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28748747/association-between-metabolic-syndrome-and-overactive-bladder-a-case-control-study
#20
Zana Saratlija Novakovic, Roberta Andrea Tesija, Livia Puljak
OBJECTIVE: The aim of this case-control study was to investigate the association between overactive bladder (OAB) and metabolic syndrome (MetS). The primary hypothesis was that OAB is significantly more prevalent among patients with MetS than in control participants. MATERIALS AND METHODS: A case-control study was conducted among 114 patients, with 57 patients in the MetS group and 57 in the control group. Study participants were recruited in a family medicine practice...
July 27, 2017: Scandinavian Journal of Urology
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