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https://www.readbyqxmd.com/read/29351556/testosterone-induced-benign-prostatic-hyperplasia-rat-and-dog-as-facile-models-to-assess-drugs-targeting-lower-urinary-tract-symptoms
#1
Jing Li, Yanxin Tian, Shimeng Guo, Haifeng Gu, Qianting Yuan, Xin Xie
Benign prostatic hyperplasia (BPH) is an age-related disease, affecting a majority of elderly men worldwide. Medical management of BPH is an alternative to surgical treatment of this disease. Currently, α1-adrenergic receptor (α1-AR) antagonists are among the first line drugs to treat BPH by reducing the tension of urinary track and thus the obstructive symptoms in voiding. In drug development, old male dogs with spontaneous BPH are considered the golden standard of the animal models. However, old dogs (>6 years) are expensive and not all old dogs develop BPH...
2018: PloS One
https://www.readbyqxmd.com/read/29346776/loss-of-an-androgen-inactivating-and-isoform-specific-hsd17b4-splice-form-enables-emergence-of-castration-resistant-prostate-cancer
#2
Hyun-Kyung Ko, Michael Berk, Yoon-Mi Chung, Belinda Willard, Rohan Bareja, Mark Rubin, Andrea Sboner, Nima Sharifi
Castration-resistant prostate cancer (CRPC) requires tumors to engage metabolic mechanisms that allow sustained testosterone and/or dihydrotestosterone to stimulate progression. 17β-Hydroxysteroid dehydrogenase type 4 (17βHSD4), encoded by HSD17B4, is thought to inactivate testosterone and dihydrotestosterone by converting them to their respective inert 17-keto steroids. Counterintuitively, HSD17B4 expression increases in CRPC and predicts poor prognosis. Here, we show that, of five alternative splice forms, only isoform 2 encodes an enzyme capable of testosterone and dihydrotestosterone inactivation...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29343749/testosterone-boosts-physical-activity-in-male-mice-via-dopaminergic-pathways
#3
Ferran Jardí, Michaël R Laurent, Nari Kim, Rougin Khalil, Dimitri De Bundel, Ann Van Eeckhaut, Lawrence Van Helleputte, Ludo Deboel, Vanessa Dubois, Dieter Schollaert, Brigitte Decallonne, Geert Carmeliet, Ludo Van den Bosch, Rudi D'Hooge, Frank Claessens, Dirk Vanderschueren
Low testosterone (T) in men, especially its free fraction, has been associated with loss of energy. In accordance, orchidectomy (ORX) in rodents results in decreased physical activity. Still, the mechanisms through which T stimulates activity remain mostly obscure. Here, we studied voluntary wheel running behavior in three different mouse models of androgen deficiency: ORX, androgen receptor (AR) knock-out (ARKO) and sex hormone binding globulin (SHBG)-transgenic mice, a novel mouse model of "low free T". Our results clearly show a fast and dramatic action of T stimulating wheel running, which is not explained by its action on muscle, as evidenced by neuromuscular studies and in a muscle-specific conditional ARKO mouse model...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29340845/dihydrotestosterone-treatment-accelerates-autograft-reversal-sciatic-nerve-regeneration-in-rats
#4
Xiaofan Yang, Pingping Xue, Ruozheng Wei, Xin Liu, Xiang Xu, Zhenyu Liu, Yanhua Chen, Zhenbing Chen
Neuroactive steroids such as progesterone, testosterone, and their derivatives have been widely studied for their neuroprotective roles in the nervous system. Autologous nerve transplantation is considered as the gold standard repair technique when primary suture is impossible; nevertheless, this method is far from ideal. In this study, we aimed to explore the impact of dihydrotestosterone (DHT), a 5α-reduced derivative of testosterone, on the recovery of peripheral nerve injury treated with autologous nerve transplantation...
January 16, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29339804/ephb6-and-testosterone-in-concert-regulate-epinephrine-release-by-adrenal-gland-chromaffin-cells
#5
Yujia Wang, Wei Shi, Alexandre Blanchette, Junzheng Peng, Shijie Qi, Hongyu Luo, Jonathan Ledoux, Jiangping Wu
Erythropoietin-producing human hepatocellular receptor (EPH) B6 (EPHB6) is a member of the receptor tyrosine kinase family. We previously demonstrated that EPHB6 knockout reduces catecholamine secretion in male but not female mice, and castration reverses this phenotype. We showed here that male EPHB6 knockout adrenal gland chromaffin cells presented reduced acetylcholine-triggered Ca2+ influx. Such reduction depended on the non-genomic effect of testosterone. Increased large conductance calcium-activated potassium channel current densities were recorded in adrenal gland chromaffin cells from male EPHB6 knockout mice but not from castrated knockout or female knockout mice...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339527/diminished-androgen-and-estrogen-receptors-and-aromatase-levels-in-hypogonadal-diabetic-men-reversal-with-testosterone
#6
Husam Ghanim, Sandeep Dhindsa, Sanaa Abuaysheh, Manav Batra, Nitesh Kuhadiya, Antoine Makdissi, Ajay Chaudhuri, Paresh Dandona
AIMS: One third of males with type 2 diabetes have hypogonadism, characterized by low total and free testosterone concentrations. We hypothesized that this condition is associated with a compensatory increase in the expression of androgen receptors (AR) and that testosterone replacement reverses these changes. We also measured estrogen receptor and aromatase expression. MATERIALS AND METHODS: This is a randomized double-blind placebo controlled trial. 32 hypogonadal and 32 eugonadal men with type 2 diabetes were recruited...
January 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29339197/differential-insulin-and-steroidogenic-signaling-in-insulin-resistant-and-non-insulin-resistant-human-luteinized-granulosa-cells-a-study-in-pcos-patients
#7
Muskaan Belani, Abhilash Deo, Preeti Shah, Manish Banker, Pawan Singal, Sarita Gupta
Insulin resistance (IR) is one of the significant aberrations in polycystic ovarian syndrome (PCOS), however is only observed in 70%-80% of obese PCOS and 20%-25% of lean PCOS. Hyperinsulinemia accompanies PCOS-IR along with hyperandrogenemia against normal insulin and androgen levels in PCOS-non insulin resistance (NIR). This could possibly be due to defects in the downstream signaling pathways. The study thus aims to unravel insulin and steroidogenic signaling pathways in luteinized granulosa cells isolated from PCOS -IR and NIR vs matched controls...
January 12, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29317066/an-exploration-of-the-hypothesis-that-testosterone-is-implicated-in-the-psychological-functioning-of-women-with-polycystic-ovary-syndrome-pcos
#8
J A Barry, F Qu, P J Hardiman
One of the diagnostic features of polycystic ovary syndrome (PCOS) is elevation of the androgen, testosterone. It is known that women with PCOS are more likely to suffer from psychological problems, especially anxiety and depression, than other women. However, little is known of how much of this is due to testosterone, and if so, what the mechanism(s) might be. This study explores the hypothesis that testosterone impacts women with PCOS both directly and indirectly, via testosterone currently in the bloodstream and through prenatal exposure...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29308681/therapeutic-considerations-of-sarcopenia-in-heart-failure-patients
#9
Masakazu Saitoh, Nicole Ebner, Stephan von Haehling, Stefan D Anker, Jochen Springer
Sarcopenia is a common feature, and affects 20-47% of patients with heart failure (HF). Sarcopenia is also an independent predictor of impaired functional capacity, even after adjusting for clinical relevant variables, which is associated with adverse outcome in patients with HF. Areas covered: Several different pathophysiological pathways are involved in sarcopenic processes including altered nutrient intake and absorption, hormonal factor, inflammatory processes, oxidative stress, cellular proteolysis, and unhealthy lifestyle...
January 7, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29299971/the-role-of-the-fas-fasl-signaling-pathway-in-environmental-toxicant-induced-testicular-cell-apoptosis-an-update
#10
Mei Wang, Ping Su
The Fas/FasL signaling pathway is one of the major pathways that regulate apoptosis. Increasing studies have shown that the activation of the Fas/FasL signaling pathway is closely associated with testicular cell apoptosis. However, the mechanism involved is still unclear. We discuss recent findings regarding the molecular mechanisms by which environmental toxicants induce testicular pathology via Fas/FasL signaling. These findings suggest that Fas/FasL signaling is employed to impact the sensitivity (a response to external factors) of germ cells, disrupt steroidogenic hormone and cytokine metabolism mediated by Sertoli cells, and elicit the activation of NFAT (nuclear factor of activated T-cells) in Leydig cell apoptosis...
January 4, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29299890/comparison-of-the-effects-of-clofibrate-and-silafibrate-on-sperm-parameters-quality-and-sex-hormones-in-male-rats
#11
Masoud Delashoub, Mojtaba Ziaee, Arash Khorrami, Seyed Mahdi Banan-Khojasteh
PURPOSE: Fibrates are drugs widely used for the treatment of hyperlipidemic disorders. Previous studies on a novel analogue of clofibrate, called silafibrate, have shown good lipid lowering effects. This study was designed to assess the role of silafibrate as a peroxisome proliferator-activated receptors (PPARs) agonist on sperm health and spermatogenesis in adult male rats. MATERIAL AND METHODS: Seventy male Wistar rats were randomly allocated into 7 groups: Cl-10, Cl-20, and Cl-40 mg/kg/day (clofibrate); Si-10, Si-20, and Si-40 mg/kg/day (silafibrate); and C, control...
January 3, 2018: Urology Journal
https://www.readbyqxmd.com/read/29299745/an-evaluation-of-g-protein-coupled-membrane-estrogen-receptor-1-level-in-stuttering
#12
Nagihan Bilal, Ergül Belge Kurutas, Israfil Orhan
OBJECTIVE: Stuttering is a widespread but little understood disease. There has been a recent increase in neuropathophysiological, genetic, and biochemical studies related to the etiopathogenesis. As developmental stuttering continues in adult males, hormonal factors are thought to have an effect. In this study, an evaluation was made for the first time of serum GPER-1 level in patients with a stutter. STUDY DESIGN: Prospective case control. MATERIALS AND METHODS: The study included 30 patients with a stutter, aged < 18 years, and 35 age-matched children as the control group...
January 3, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29299171/melatonin-up-regulates-the-expression-of-the-gata-4-transcription-factor-and-increases-testosterone-secretion-from-leydig-cells-through-ror%C3%AE-signaling-in-an-in-vitro-goat-spermatogonial-stem-cell-differentiation-culture-system
#13
Shou-Long Deng, Yan Zhang, Kun Yu, Xiu-Xia Wang, Su-Ren Chen, De-Ping Han, C Yan Cheng, Zheng-Xing Lian, Yi-Xun Liu
Because androgen function is regulated by its receptors, androgen-androgen receptor signaling is crucial for regulating spermatogenesis. Androgen is mainly testosterone secreted by testis. Based on the results of early studies in goats, the administration of melatonin over an extended period of time increases steroid production, but the underlying mechanism remains unclear. Here, we report the expression of the melatonin membrane receptors MT1 and MT2 and the retinoic acid receptor-related orphan receptor-alpha (RORα) in the goat testis...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29295870/effect-of-liraglutide-on-atrial-natriuretic-peptide-adrenomedullin-and-copeptin-in-pcos
#14
Signe Frøssing, Malin Nylander, Caroline Kistorp, Sven O Skouby, Jens Faber
CONTEXT: Women with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease (CVD), and biomarkers can be used to detect early subclinical CVD. Midregional-pro-adrenomedullin (MR-proADM), midregional-pro-atrial natriuretic peptide (MR-proANP) and copeptin are all associated with CVD and part of the delicate system controlling fluid and hemodynamic homeostasis through vascular tonus and diuresis. The GLP-1 receptor agonist liraglutide, developed for treatment of type 2 diabetes (T2D), improves cardiovascular outcomes in patients with T2D including a decrease in particular MR-proANP...
January 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29289721/spinal-sigma-1-receptor-mediated-dephosphorylation-of-astrocytic-aromatase-plays-a-key-role-in-formalin-induced-inflammatory-nociception
#15
Hoon-Seong Choi, Mi-Ji Lee, Sheu-Ran Choi, Branden A Smeester, Alvin J Beitz, Jang-Hern Lee
Aromatase is a key enzyme responsible for the biosynthesis of estrogen from testosterone. Although recent evidence indicates that spinal cord aromatase participates in nociceptive processing, the mechanisms underlying its regulation and its involvement in nociception remain unclear. The present study focuses on the potential role of astrocyte aromatase in formalin-induced acute pain and begins to uncover one mechanism by which spinal aromatase activation is controlled. Following intraplantar formalin injection, nociceptive responses were quantified and immunohistochemistry/co-immunoprecipitation assays were used to investigate the changes in spinal Fos expression and the phospho-serine levels of spinal aromatase...
December 28, 2017: Neuroscience
https://www.readbyqxmd.com/read/29289696/assessment-of-the-analgesic-dipyrone-as-a-possible-anti-androgenic-endocrine-disruptor
#16
Marcella Tapias Passoni, Maja Nørgaard Kristensen, Rosana Nogueira Morais, Claudia Woitkowiak, Ana Claudia Boareto, Bruna Andreotti da Silva Amaral, Nicole Grechi, Paulo Roberto Dalsenter, Cecilie Hurup Munkboel, Bjarne Styrishave, David Møbjerg Kristensen, Caroline Gomes, Bennard van Ravenzwaay, Anderson Joel Martino-Andrade
Mild analgesics have been associated with antiandrogenic effects, but there are no such studies on dipyrone, despite its high prevalence of use in many countries. We examined the production of steroid hormones in human H295R cells after exposure to dipyrone and two metabolites, 4-Methylaminoantipyrine (MAA) and 4-Aminoantipyrine (AA), as well as fetal testicular testosterone production in rats following maternal dipyrone exposure. Androgen agonistic/antagonistic effects were examined in vitro for dipyrone and its metabolites in the Yeast Androgen Screen (YAS) assay and in vivo for dipyrone through the Hershberger assay...
December 28, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29287198/upregulation-of-peroxisome-proliferator-activated-receptor-alpha-by-fenofibrate-in-induced-testicular-ischemia-reperfusion
#17
Marwa M M Refaie
Torsion of the spermatic cord is a common urological emergency among infants and adolescents that can lead to testicular necrosis and infertility. We investigated the effect of fenofibrate (FEN) on induced testicular ischemia reperfusion (testicular (I-R). FEN (100, 300 mg/kg/day) was administered orally in presence or absence of testicular (I-R). We measured testicular weight changes and serum testosterone level. In addition; Testicular tissue reduced glutathione (GSH), malondialdehyde (MDA), total nitrites (NOx) and superoxide dismutase (SOD) activity were measured...
December 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29276148/testosterone-diminishes-cabazitaxel-efficacy-and-intratumoral-accumulation-in-a-prostate-cancer-xenograft-model
#18
Lisanne Mout, Ronald de Wit, Debra Stuurman, Esther Verhoef, Ron Mathijssen, Corrina de Ridder, Martijn Lolkema, Wytske van Weerden
Inactivation of the androgen receptor (AR) pathway by androgen deprivation therapy (ADT) is the mainstay of (metastatic) prostate cancer therapy. Ultimately, the AR pathway will be re-activated despite castrate levels of circulating androgens. Thereby, maintaining its role even in castration resistant prostate cancer (CRPC). The recent STAMPEDE and CHAARTED trials showed that docetaxel in combination with ADT increased survival in hormone sensitive prostate cancer patients, suggesting cross-talk between AR signaling and chemotherapy efficacy...
December 20, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29275169/testosterone-induces-hyporesponsiveness-by-interfering-with-ip3-receptors-in-guinea-pig-airway-smooth-muscle
#19
Luis M Montaño, Edgar Flores-Soto, Jorge Reyes-García, Verónica Díaz-Hernández, Abril Carbajal-García, Elías Campuzano-González, G Lizbeth Ramírez-Salinas, Marco A Velasco-Velázquez, Bettina Sommer
Asthma symptoms have been associated with sex steroids. During childhood, this illness seems more frequent in boys than in girls and this tendency reverts in puberty when it is more severe in women. Testosterone (TES), at supraphysiological concentrations, relaxed pre-contracted airway smooth muscle, but its effects at physiological concentrations have not been thoroughly studied. We explored this possibility in guinea pig tracheal smooth muscle. In myocytes TES (10 nM) abolished carbachol (CCh)-induced intracellular Ca2+ concentration ([Ca2+]i) increment...
December 21, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29259324/revisiting-medial-preoptic-area-plasticity-induced-in-male-mice-by-sexual-experience
#20
Arnaud Jean, Pauline Bonnet, Philippe Liere, Sakina Mhaouty-Kodja, Helene Hardin-Pouzet
Sexual experience in male rodents, induced by a first exposure to a receptive female, improves efficiency of following copulations. In mice, the mechanisms supporting this improvement are poorly understood. We characterized molecular modifications of the mouse hypothalamic medial preoptic area (mPOA), the main integrative structure for male sexual behaviour, after a single mating event. This paradigm induced long-lasting behavioural improvements and mPOA morphological changes, evidenced by dendritic spine maturation and an increase in the acetylated and tri-methylated forms of histone H3...
December 19, 2017: Scientific Reports
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