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https://www.readbyqxmd.com/read/27921086/ovarian-and-uterine-alterations-following-forced-swimming-an-immunohistochemical-study
#1
Seyedeh Nazanin Seyed Saadat, Fahimeh Mohammadghasemi, Hannan Ebrahimi, Hanieh Rafati Sajedi, Gelayol Chatrnour
BACKGROUND: Physical exercise is known to be a stressor stimulus that leads to reproductive disruption. OBJECTIVE: The aim of this study was to evaluate the effect of forced swimming on the uterus and ovaries in mice. MATERIALS AND METHODS: Adult mice (N=24) were divided into the following three groups: A, control; B, swimming in water (10(o)C); and C, swimming in water (23(o)C). Swimmers swam for 5 min daily for 5 consecutive days/ wk during 2 wks...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27911591/type-b-insulin-resistance-masquerading-as-ovarian-hyperthecosis
#2
Rebecca J Brown, Jalaja Joseph, Elaine Cochran, Cornelia Gewert, Robert Semple, Phillip Gorden
CONTEXT: Hyperinsulinemia can lead to pathologic ovarian growth and androgen production. CASE DESCRIPTION: A 29 year old woman developed an autoantibody to the insulin receptor (Type B insulin resistance), causing extreme insulin resistance and hyperinsulinemia. Testosterone levels were elevated to the adult male range. Treatment with gonadotropin releasing hormone (GnRH) analog led to normalization of testosterone, despite persistent extreme insulin resistance...
December 2, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27907037/reliability-of-potential-pain-biomarkers-in-the-saliva-of-healthy-subjects-inter-individual-differences-and-intersession-variability
#3
Eva M Sobas, Roberto Reinoso, Rubén Cuadrado-Asensio, Itziar Fernández, Miguel J Maldonado, José C Pastor
AIM: Salivary cortisol, α-amylase (sAA), secretory IgA (sIgA), testosterone, and soluble fraction of receptor II of TNFα (sTNFαRII) could serve as objective pain measures, but the normal variability of these potential biomarkers is unknown. PATIENTS & METHODS: Saliva was collected with the passive secretion method from 34, pain-free subjects in two single samples at least 24 hours apart. Biomarker variation and intersession reliability were assessed with the intraclass correlation coefficient (ICC)...
2016: PloS One
https://www.readbyqxmd.com/read/27903287/high-content-imaging-quantification-of-multiple-in-vitro-human-neurogenesis-events-after-neurotoxin-exposure
#4
Xian Wu, Anirban Majumder, Robin Webb, Steven L Stice
BACKGROUND: Our objective was to test neural active compounds in a human developmental neurotoxicity (DNT) model that represents neural tube stages of vulnerability. Previously we showed that 14 days in vitro (DIV 14) was sufficient to generate cryopreserved neuronal cells for post thaw neurite recovery assays. However, short exposure and assessment may not detect toxicants that affect an early neurogenesis continuum, from a mitotic human neural progenitor (hNP) cell population through the course of neurite outgrowth in differentiating neurons...
December 1, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27899892/age-dependent-hepatic-udp-glucuronosyltransferase-gene-expression-and-activity-in-children
#5
Elizabeth Neumann, Huma Mehboob, Jacqueline Ramírez, Snezana Mirkov, Min Zhang, Wanqing Liu
UDP-glucuronosyltransferases (UGTs) are important phase II drug metabolism enzymes. The aim of this study was to explore the relationship between age and changes in mRNA expression and activity of major human hepatic UGTs, as well as to understand the potential regulatory mechanism underlying this relationship. Using previously generated data, we investigated age-dependent mRNA expression levels of 11 hepatic UGTs (UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A9, UGT2B4, UGT2B7, UGT2B10, UGT2B15, and UGT2B17) and 16 transcription factors (AHR, AR, CAR, ESR2, FXR, GCCR, HNF1a, HNF3a, HNF3b, HNF4a, PPARA, PPARG, PPARGC, PXR, SP1, and STAT3) in liver tissue of donors (n = 38) ranging from 0 to 25 years of age...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27891737/role-of-resistance-physical-exercise-in-preventing-testicular-damage-caused-by-chronic-ethanol-consumption-in-uchb-rats
#6
Gessica Dutra Gonçalves, Nichelle Antunes Vieira, Henrique Rodrigues Vieira, Aline Dias Valério, Gláucia Elóisa Munhoz de Lion Siervo, Patricia Fernanda Felipe Pinheiro, Francisco Eduardo Martinez, Flávia Alessandra Guarnier, Giovana Rampazzo Teixeira, Glaura Scantamburlo Alves Fernandes
Ethanol consumption is associated with spermatogenesis damage and testosterone level alterations. Alcohol remains the most commonly used substance among athletes and sports enthusiasts. This study evaluated whether resistance physical exercise can reduce the testicular damage caused by ethanol exposure. A total of 36 ethanol drinking (UChB) rats were divided into four groups: C (control rats), ETOH (ethanol consumption), ETOH + T (ethanol consumption + physical training), and T (group physical training)...
November 28, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27888546/sex-differences-in-depolarizing-actions-of-gabaa-receptor-activation-in-rat-embryonic-hypothalamic-neurons
#7
Franco R Mir, Hugo F Carrer, María J Cambiasso
GABAA receptor activation exerts trophic actions in immature neurons through depolarization of resting membrane potential. The switch to its classical hyperpolarizing role is developmentally regulated. Previous results suggest that a hormonally biased sex difference exists at the onset of the switch in hypothalamic neurons. The aim of this work was to evaluate sex differences in GABAA receptor function of hypothalamic neurons before brain masculinization by gonadal hormones. Hypothalamic cells were obtained from embryonic day 16 male and female rat foetuses, 2 days before the peak of testosterone production by the foetal testis, and grown in vitro for 9 days...
November 5, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27886378/interactive-effect-of-corticosterone-and-lactate-on-regulation-of-testosterone-production-in-rat-leydig-cells
#8
Chih-Chieh Chen, Chien-Wei Chen, Po-Han Lin, Jou-Chun Chou, Ting-Chun Weng, Cai-Yun Jian, Sindy Hu, Wei-Ho Lai, Fu-Kong Lieu, Shyi-Wu Wang, Paulus S Wang
The increasing intensity of exercise enhanced corticosterone and lactate production in both humans and rodents. Our previous studies also demonstrated that lactate could stimulate testosterone production in vivo and in vitro. However, the production of testosterone in response to combined corticosterone and lactate on Leydig cells, and underlying molecular mechanisms are remained unclear. This study investigated the changes in testosterone levels of Leydig cells upon exposure to lactate, corticosterone or combination of both, and revealed the detailed mechanisms...
November 25, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27885811/17-%C3%AE-estradiol-inhibits-hepatitis-c-virus-mainly-by-interference-with-the-release-phase-of-its-life-cycle
#9
Andrea Magri, Matteo N Barbaglia, Chiara Z Foglia, Elisa Boccato, Michela E Burlone, Sarah Cole, Paola Giarda, Elena Grossini, Arvind H Patel, Rosalba Minisini, Mario Pirisi
BACKGROUND & AIMS: Oestrogen and oestrogen-mediated signalling protect from hepatitis C virus through incompletely understood mechanisms. We aimed to ascertain which phase(s) of hepatitis C virus life cycle is/are affected by oestrogens. METHODS: Huh7 cells infected with the JFH1 virus (genotype 2a) were exposed to dehydroepiandrosterone, testosterone, progesterone and 17β-estradiol (tested with/without its receptor antagonist fulvestrant). Dose-response curves were established to calculate half maximal inhibitory concentration values...
November 7, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27881754/neuroendocrine-correlates-of-sex-role-reversal-in-barred-buttonquails
#10
Cornelia Voigt
Sex differences in brain structure and behaviour are well documented among vertebrates. An excellent model exploring the neural mechanisms of sex differences in behaviour is represented by sex-role-reversed species. In the majority of bird species, males compete over access to mates and resources more strongly than do females. It is thought that the responsible brain regions are therefore more developed in males than in females. Because these behaviours and brain regions are activated by androgens, males usually have increased testosterone levels during breeding...
November 30, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27880726/chrysophanic-acid-reduces-testosterone-induced-benign-prostatic-hyperplasia-in-rats-by-suppressing-5%C3%AE-reductase-and-extracellular-signal-regulated-kinase
#11
Dong-Hyun Youn, Jinbong Park, Hye-Lin Kim, Yunu Jung, JongWook Kang, Mi-Young Jeong, Gautam Sethi, Kwang Seok Ahn, Jae-Young Um
Benign prostatic hyperplasia (BPH) is one of the most common chronic diseases in male population, of which incidence increases gradually with age. In this study, we investigated the effect of chrysophanic acid (CA) on BPH. BPH was induced by a 4-week injection of testosterone propionate (TP). Four weeks of further injection with vehicle, TP, TP + CA, TP + finasteride was carried on. In the CA treatment group, the prostate weight was reduced and the TP-induced histological changes were restored as the normal control group...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27879963/hypogonadism-and-non-alcoholic-fatty-liver-disease
#12
Gesthimani Mintziori, Pavlos Poulakos, Christos Tsametis, Dimitrios G Goulis
Non-alcoholic fatty liver disease (NAFLD) is more common in men than in women. Thus, it has been suggested that sex steroids do have a role in the development of NAFLD. The aim of the current paper is to illustrate the association between NAFLD and hypogonadism, by reviewing data derived from both human and animal studies. The prevalence of NAFLD is high in men with hypogonadism, including those with idiopathic hypogonadotropic hypogonadism (IHH), as well as in women in post- menopause, those under estrogen receptor antagonist treatment or women with Turner syndrome...
November 23, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27876080/effect-of-testosterone-on-the-connexin37-of-sexual-mature-mouse-cumulus-oocyte-complex
#13
Yangyang Zhang, Yang Xu, Yanrong Kuai, Sheng Wang, Qing Xue, Jing Shang
BACKGROUND: Recent researches demonstrate that pre-treatment with androgen could increase retrieved oocytes number and clinical pregnancy rate in poor ovarian response (POR) patients. In view of gap junction intercellular communication (GJIC) is important for follicular growth, and androgen plays an important role in improving prognosis of POR patients, we speculate that androgen can increase the expression of connexin in follicle cells, and improve ovarian microenvironment, thus can promote ovarian response...
November 23, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27872000/is-testosterone-a-food-for-the-brain
#14
REVIEW
Giacomo Ciocca, Erika Limoncin, Eleonora Carosa, Stefania Di Sante, Giovanni L Gravina, Daniele Mollaioli, Daniele Gianfrilli, Andrea Lenzi, Emmanuele A Jannini
INTRODUCTION: Testosterone is fundamental for psychological, sexological, cognitive, and reproductive aspects, and its lack or reduction largely impacts the quality of life in males and females. AIM: Therefore, the aim of this review is to describe the role of testosterone in the neurophysiology of the brain and related aspects regarding the quality of general and sexual life. METHODS: We listed and discussed the principal studies on the role of testosterone in the brain regarding sexual health, psychopathological conditions, and the elderly...
January 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27870444/sex-differences-and-estrogen-regulation-of-bdnf-gene-expression-but-not-propeptide-content-in-the-developing-hippocampus
#15
Katherine E Kight, Margaret M McCarthy
Sex differences in adult brain function are frequently determined developmentally through the actions of steroid hormones during sensitive periods of prenatal and early postnatal life. In rodents, various cellular end points of the developing brain are affected by estradiol that is derived from the aromatization of circulating testosterone and/or synthesized within the brain. We have previously described a sex difference in neurogenesis in the hippocampus of neonatal rats that is modulated by estradiol. In this report, we examined a potential downstream regulator of the effects of estradiol on hippocampal cell proliferation by measuring gene expression of brain-derived neurotrophin (BDNF) in male and female neonatal rats in response to estradiol...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27866977/the-anti-hyperplasia-anti-oxidative-and-anti-inflammatory-properties-of-qing-ye-dan-and-swertiamarin-in-testosterone-induced-benign-prostatic-hyperplasia-in-rats
#16
Xinying Wu, Ye Gu, Lun Li
Qing Ye Dan (QYD) is the whole plant of Swertia mileensis and used in Chinese folk medicine for the treatment of prostatitis, benign prostatic hyperplasia (BPH) and so on. This study was to investigate the effects of QYD and its main component swertiamarin on BPH induced by testosterone in rats. The prostatic expressions of vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), basic fibroblast growth factor (βFGF) and proliferating cell nuclear antigen (PCNA) were detected by immunohistochemistry assay...
November 17, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27866972/letrozole-regulates-actin-cytoskeleton-polymerization-dynamics-in-a-src-1-dependent-manner-in-the-hippocampus-of-mice
#17
Yangang Zhao, Yanlan Yu, Yuanyuan Zhang, Li He, Linli Qiu, Jikai Zhao, Mengying Liu, Jiqiang Zhang
In the hippocampus, local estrogens (E2) derived from testosterone that is catalyzed by aromatase play important roles in the regulation of hippocampal neural plasticity, but the underlying mechanisms remain unclear. The actin cytoskeleton contributes greatly to hippocampal synaptic plasticity; however, whether it is regulated by local E2 and the related mechanisms remain to be elucidated. In this study, we first examined the postnatal developmental profiles of hippocampal aromatase and specific proteins responsible for actin cytoskeleton dynamics...
November 17, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27856715/highlighted-topics-recovery-from-exercise-recovery-responses-of-testosterone-growth-hormone-and-igf-1-after-resistance-exercise
#18
William J Kraemer, Nicholas A Ratamess, Bradley J Nindl
The complexity of the endocrine pathways during recovery related to anabolic function belie an over simplistic approach to its study. This review is to examines the role of resistance exercise (RE) on the recovery responses of three major anabolic hormones testosterone, growth hormone(s) and insulin-like growth factor-I. Each hormone has a complexity related to differential pathways of action as well as interactions with binding proteins and receptor interactions. Testosterone is the primary anabolic hormone and its concentration changes during the recovery period depending upon the up- or down-regulation of the androgen receptor...
November 17, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27849622/novel-mutations-of-the-srd5a2-and-ar-genes-in-thai-patients-with-46-xy-disorders-of-sex-development
#19
Chupong Ittiwut, Jaturong Pratuangdejkul, Vichit Supornsilchai, Sasipa Muensri, Yodporn Hiranras, Taninee Sahakitrungruang, Suttipong Watcharasindhu, Kanya Suphapeetiporn, Vorasuk Shotelersuk
BACKGROUND: Abnormalities of dihydrotestosterone conversion [5α-reductase deficiency: online Mendelian inheritance in man (OMIM) 607306] or actions of androgens [partial androgen insensitivity syndrome (PAIS): OMIM 312300] during the 8th-12th weeks of gestation cause varying degrees of undervirilized external genitalia in 46, XY disorders of sex development (DSD) with increased testosterone production. The objective of the study was to determine clinical and genetic characteristics of Thai patients with 46, XY DSD...
November 16, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27849354/the-treatment-effects-of-flaxseed-derived-secoisolariciresinol-diglycoside-and-its-metabolite-enterolactone-on-benign-prostatic-hyperplasia-involve-the-g-protein-coupled-estrogen-receptor-1
#20
Guan-Yu Ren, Chun-Yang Chen, Wei-Guo Chen, Ya Huang, Li-Qiang Qin, Li-Hua Chen
Secoisolariciresinol diglucoside (SDG), a lignan extracted from flaxseed, has been shown to suppress benign prostatic hyperplasia (BPH). However, little is known about the mechanistic basis for its anti-BPH activity. The present study showed that enterolactone (ENL), the mammalian metabolite of SDG, shared the similar binding site of G1 on a new type of membranous estrogen receptor, G-protein-coupled estrogen eceptor 1 (GPER), by docking simulations method. ENL and G1 (the specific agonist of GPER) inhibited the proliferation of human prostate stromal cell line WPMY-1 as shown by MTT assay and arrested cell cycle at the G0/G1 phase, which was displayed by propidium iodide staining following flow cytometer examination...
December 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
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