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https://www.readbyqxmd.com/read/29231996/molecular-mechanisms-of-tributyltin-induced-alterations-in-cholesterol-homeostasis-and-steroidogenesis-in-hamster-testis-in-vivo-and-in-vitro-studies
#1
V Kanimozhi, K Palanivel, M A Akbarsha, B Kadalmani
Tributyltins (TBT) are ubiquitous and persistent environmental contaminants that disturb normal endocrine function including gonadal function in humans and marine organisms. TBT was administered through oral route to male Syrian hamsters at daily doses of 50, 100 and 150 ppm/kg for 65 days. Changes in testis morphology, immunohistochemistry of iNOS, 3β-HSD and 17β-HSD, cholesterol transport receptor, nuclear receptors, and transcription factors were analyzed. TBT treatment affected each of these parameters to significant levels in a dose-dependent manner compared to vehicle treated control...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29224108/negative-impact-of-testosterone-deficiency-and-5%C3%AE-reductase-inhibitors-therapy-on-metabolic-and-sexual-function-in-men
#2
Abdulmaged M Traish
Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via aromatization into estradiol (E2) modulates important biochemical signaling pathways of human physiology and plays a critical role in the growth and/or maintenance of functions in a host of tissues and organs. T and 5α-DHT play an important role in regulating physiology of the muscle, adipose tissue, liver, bone, and central nervous system, as well as reproductive and sexual functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224095/sex-differences-in-muscle-wasting
#3
Lindsey J Anderson, Haiming Liu, Jose M Garcia
With aging and other muscle wasting diseases, men and women undergo similar pathological changes in skeletal muscle: increased inflammation, enhanced oxidative stress, mitochondrial dysfunction, satellite cell senescence, elevated apoptosis and proteasome activity, and suppressed protein synthesis and myocyte regeneration. Decreased food intake and physical activity also indirectly contribute to muscle wasting. Sex hormones also play important roles in maintaining skeletal muscle homeostasis. Testosterone is a potent anabolic factor promoting muscle protein synthesis and muscular regeneration...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29221813/neonatal-programming-with-testosterone-propionate-reduces-dopamine-transporter-expression-in-nucleus-accumbens-and-methylphenidate-induced-locomotor-activity-in-adult-female-rats
#4
Tatiana Dib, Jonathan Martínez-Pinto, Miguel Reyes-Parada, Gonzalo E Torres, Ramón Sotomayor-Zárate
Research in programming is focused on the study of stimuli that alters sensitive periods in development, such as prenatal and neonatal stages, that can produce long-term deleterious effects. These effects can occur in various organs or tissues such as the brain, affecting brain circuits and related behaviors. Our laboratory has demonstrated that neonatal programming with sex hormones affects the mesocorticolimbic circuitry, increasing the synthesis and release of dopamine (DA) in striatum and nucleus accumbens (NAcc)...
December 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29216406/high-throughput-h295r-steroidogenesis-assay-utility-as-an-alternative-and-a-statistical-approach-to-characterize-effects-on-steroidogenesis
#5
Derik E Haggard, Agnes L Karmaus, Matthew T Martin, Richard S Judson, R Woodrow Setzer, Katie Paul Friedman
The U.S. Environmental Protection Agency Endocrine Disruptor Screening Program and the Organization for Economic Co-operation and Development (OECD) have used the human adrenocarcinoma (H295R) cell-based assay to predict chemical perturbation of androgen and estrogen production. Recently, a high-throughput H295R (HT-H295R) assay was developed as part of the ToxCast program that includes measurement of 11 hormones, including progestagens, corticosteroids, androgens, and estrogens. To date, 2012 chemicals have been screened at one concentration; of these, 656 chemicals have been screened in concentration-response...
December 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29203165/sex-hormone-levels-in-the-brain-of-d-aspartate-treated-rats
#6
Maria Maddalena Di Fiore, Alessandra Santillo, Sara Falvo, Gabriella Chieffi Baccari, Massimo Venditti, Federica Di Giacomo Russo, Monica Lispi, Antimo D'Aniello
d-Aspartate (d-Asp) is an endogenous amino acid present in the central nervous system and endocrine glands of various animal taxa. d-Asp is implicated in neurotransmission, physiology of learning, and memory processes. In gonads, it plays a crucial role in sex hormone synthesis. We have investigated the effects of chronic (30 days d-Asp drinking solution) and acute (i.p. injection of 2μmol/g bw d-Asp) treatments on sex steroid synthesis in rat brain. Furthermore, to verify the direct effect of d-Asp on neurosteroidogenic enzyme activities, brain homogenates were incubated with different substrates (cholesterol, progesterone, or testosterone) with or without the addition of d-Asp...
December 1, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29196065/steroidogenic-enzymes-their-products-and-sex-steroid-receptors-during-testis-development-and-spermatogenesis-in-the-domestic-cat-felis-catus
#7
Beate C Braun, Minami W Okuyama, Karin Müller, Martin Dehnhard, Katarina Jewgenow
In the present study we comprehensively characterize intratesticular sex steroid production, metabolism and receptors in the domestic cat to elucidate the role of testosterone, estradiol and progesterone in testis development, steroid synthesis and spermatogenesis. There is a great demand for new concepts of fertility control in domestic (feral) cats and wild felids. The acquired knowledge will help to understand the regulation of spermatogenesis in felids, and may reveal new target points for male contraception...
November 28, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29174867/the-synthesis-of-steroids-by-taenia-crassiceps-wfu-cysticerci-and-tapeworms-is-related-to-the-developmental-stages-of-the-parasites
#8
J M Patricio-Gómez, R A Valdez, A Veloz, L Aguilar-Vega, R Zurabian, M C Romano
Taeniids tapeworms are hermaphroditic helminths that gradually develop testis and ovaries in their reproductive units. The larval stage of the tapeworms named cysticercus is a vesicle that contains the scolex and proliferates asexually in the abdominal cavity of mice. Once in the host, they evaginate, attach to the gut and develop into an adult organism, the tapeworm. We have previously reported reported that T. crassiceps ORF and solium cysticerci transform steroid precursors to androgens and estrogens. Taenia crassiceps WFU cysticerci can also synthesize corticosteroids...
November 22, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29167276/pten-loss-promotes-intratumoral-androgen-synthesis-and-tumor-microenvironment-remodeling-via-aberrant-activation-of-runx2-in-castration-resistant-prostate-cancer
#9
Yinhui Yang, Yang Bai, Yundong He, Yu Zhao, Jiaxiang Chen, Linlin Ma, Yunqian Pan, Michael Hinten, Jun Zhang, R Jeffrey Karnes, Manish Kohli, Jennifer J Westendorf, Benyi Li, Runzhi Zhu, Haojie Huang, Wanhai Xu
PURPOSE: Intratumoral androgen synthesis (IAS) is a key mechanism promoting androgen receptor (AR) reactivation and anti-androgen resistance in castration-resistant prostate cancer (CRPC). However, signaling pathways driving aberrant IAS remain poorly understood.  Experimental Design: The effect of components of the AKT-RUNX2-osteocalcin (OCN)-GPRC6A-CREB signaling axis on expression of steroidogenesis genes CYP11A1 and CYP17A1 and testosterone level were examined in PTEN-null human PCa cell lines...
November 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29149058/neurotrophic-and-neuroregenerative-effects-of-gh-igf1
#10
Vittorio Emanuele Bianchi, Vittorio Locatelli, Laura Rizzi
INTRODUCTION: Human neurodegenerative diseases increase progressively with age and present a high social and economic burden. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are both growth factors exerting trophic effects on neuronal regeneration in the central nervous system (CNS) and peripheral nervous system (PNS). GH and IGF-1 stimulate protein synthesis in neurons, glia, oligodendrocytes, and Schwann cells, and favor neuronal survival, inhibiting apoptosis. This study aims to evaluate the effect of GH and IGF-1 on neurons, and their possible therapeutic clinical applications on neuron regeneration in human subjects...
November 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29142409/reversible-testicular-toxicity-of-piperine-on-male-albino-rats
#11
Gopichand Chinta, Mohane Selvaraj Coumar, Latha Periyasamy
Background: Piperine was widely used in traditional medicine for inducing sterility and abortion. Objective: To evaluate the effect of the piperine on testis of male albino rats. Materials and Methods: Adult male rats were divided into four groups (n = 12). Group I (control): Rats were given vehicle p.o. i.e. 0.5% carboxymethyl cellulose in normal saline daily for 60 days, Group II (ED): Rats received piperine at a dose of 10 mg/kg body weight (b...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29128547/associations-between-asymmetric-dimethylarginine-adma-nitrite-dependent-renal-carbonic-anhydrase-activity-and-plasma-testosterone-levels-in-hypogonadal-men
#12
Dimitrios Tsikas, Manfred Kinzel
BACKGROUND: Circulating inorganic nitrite (NO2(-)) is an abundant nitric oxide (NO) reservoir. Renal carbonic anhydrase (CA) mediates the absorption of urinary nitrite. The urinary nitrate-to-nitrite molar ratio UNOxR is a measure of nitrite-dependent renal CA activity. The CA family is also involved in the bioactivation of nitrite to S-nitrosothiols and NO. Thus, CA isoforms may combat atherosclerosis. METHODS: In plasma and urine of ten hypogonadal men we measured the major NO metabolites nitrite and nitrate, and the endogenous inhibitor of NO synthase (NOS) asymmetric dimethylarginine (ADMA) before and after a 24-weeks testosterone treatment to normalize plasma testosterone levels...
November 8, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29127254/steroidogenic-abnormalities-in-translocator-protein-knockout-mice-and-significance-in-the-aging-male
#13
Anna M Barron, Bin Ji, Seiji Kito, Tetsuya Suhara, Makoto Higuchi
The translocator protein (TSPO) has been proposed to act as a key component in a complex important for mitochondrial cholesterol importation, which is the rate-limiting step in steroid hormone synthesis. However, TSPO function in steroidogenesis has recently been challenged by the development of TSPO knockout (TSPO-KO) mice, as they exhibit normal baseline gonadal testosterone and adrenal corticosteroid production. Here we demonstrate that despite normal androgen levels in young male TSPO-KO mice, TSPO deficiency alters steroidogenic flux and results in reduced total steroidogenic output...
November 10, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29100632/the-anti-estrogenicity-of-chronic-exposure-to-semicarbazide-in-female-japanese-flounders-paralichthys-olivaceus-and-its-potential-mechanisms
#14
Zonghao Yue, Miao Yu, Haifeng Zhao, Jun Wang, Xiaona Zhang, Hua Tian, Wei Wang, Shaoguo Ru
This study investigated the anti-estrogenic effects of chronic exposure to a new marine pollutant, semicarbazide (SMC; 1, 10, and 100μg/L), in female Paralichthys olivaceus, as well as the associated mechanism. After 130days of exposure, plasma 17β-estradiol and testosterone concentrations, and hepatic estrogen receptors, vitellogenin, and choriogenin mRNA levels decreased significantly in SMC-exposed groups. Moreover, down-regulation of genes in the hypothalamic-pituitary-gonadal axis, including gonadotropin-releasing hormone, gonadotropic hormones and their receptors, the steroidogenic acute regulatory protein, 17α-hydroxylase, 17β-hydroxysteroid dehydrogenase, and cytochrome P450 19A, was observed after SMC exposure...
October 31, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29078716/interaction-of-sex-chromosome-complement-gonadal-hormones-and-neuronal-steroid-synthesis-on-the-sexual-differentiation-of-mammalian-neurons
#15
Maria Julia Cambiasso, Carla Daniela Cisternas, Isabel Ruiz-Palmero, Maria Julia Scerbo, Maria Angeles Arevalo, Iñigo Azcoitia, Luis M Garcia-Segura
Female mouse hippocampal and hypothalamic neurons growing in vitro show a faster development of neurites than male mouse neurons. This sex difference in neuritogenesis is determined by higher expression levels of the neuritogenic factor neurogenin 3 in female neurons. Experiments with the four core genotype mouse model, in which XX and XY animals with male gonads and XX and XY animals with female gonads are generated, indicate that higher levels of neurogenin 3 in developing neurons are determined by the presence of the XX chromosome complement...
October 27, 2017: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29077874/urinary-cadmium-excretion-is-associated-with-increased-synthesis-of-cortico-and-sex-steroids-in-a-population-study
#16
Murielle Bochud, Judith Jenny-Burri, Menno Pruijm, Belen Ponte, Idris Guessous, Georg Ehret, Dusan Petrovic, Vincent Dudler, Max Haldimann, Geneviève Escher, Bernhard Dick, Markus Mohaupt, Fred Paccaud, Michel Burnier, Antoinette Péchère-Bertschi, Pierre-Yves Martin, Bruno Vogt, Daniel Ackermann
Context: Urinary cadmium (Cd) excretion is associated with cancer and cardiovascular morbidity. A potential intermediate mechanism could be hormone-related by disturbing steroidogenesis in gonads and adrenal glands. Objective: We tested whether urinary Cd and the excretion of metabolites of sex and corticosteroids are correlated in the general adult population. Setting: The Swiss Kidney Project on Genes in Hypertension (SKIPOGH) is a multicentric family-based population study...
October 25, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29073541/melatonin-promotes-sheep-leydig-cell-testosterone-secretion-in-a-co-culture-with-sertoli-cells
#17
Shou-Long Deng, Zhi-Peng Wang, Cheng Jin, Xiao-Long Kang, Aalia Batool, Yan Zhang, Xiao-Yu Li, Xiu-Xia Wang, Su-Ren Chen, Chawn-Shang Chang, C Yan Cheng, Zheng-Xing Lian, Yi-Xun Liu
Leydig cells synthesize and secrete testosterone, and are regulated by Sertoli cells. These two cell types may work together to regulate testicular androgen production. Studies have shown that Leydig cell androgen synthesis can be dramatically enhanced by Sertoli cells in the presence of melatonin, which can regulate the secretory function of Leydig and Sertoli cells. However, the molecular mechanism of melatonin-regulated Leydig cell androgen production via Sertoli cells remains unclear. Here, we found that 10(-7) M melatonin increased testosterone production in co-cultured Leydig and Sertoli cells isolated from sheep...
October 17, 2017: Theriogenology
https://www.readbyqxmd.com/read/29054014/sex-differences-in-behavioral-and-neurochemical-effects-of-gonadectomy-and-aromatase-inhibition-in-rats
#18
N Kokras, N Pastromas, D Papasava, C de Bournonville, C A Cornil, C Dalla
Aromatase inhibitors, which are widely used for the treatment of estrogen-dependent cancers, have been associated with psychiatric side effects ranging from mania to depression. In the present study, we investigated sex differences in the behavioral and neurochemical effects of aromatase inhibition on male and female, sham-operated or gonadectomized adult rats. Three weeks after surgery, rats received chronic treatment with the aromatase inhibitor letrozole or vehicle and were then subjected to the open field test, which assesses general activity...
October 10, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29040059/circadian-rhythm-genes-mediate-fenvalerate-induced-inhibition-of-testosterone-synthesis-in-mouse-leydig-cells
#19
Yichen Guo, Ouxi Shen, Jingjing Han, Hongyu Duan, Siyuan Yang, Zhenghong Zhu, Jian Tong, Jie Zhang
Fenvalerate (Fen), a widely used pesticide, is known to impair male reproductive functions by mechanisms that remain to be elucidated. Recent studies indicated that circadian clock genes may play an important role in successful male reproduction. The aim of this study was to determine the effects of Fen on circadian clock genes involved in the biosynthesis of testosterone using TM3 cells derived from mouse Leydig cells. Data demonstrated that the circadian rhythm of testosterone synthesis in TM3 cells was disturbed following Fen treatment as evidenced by changes in the circadian rhythmicity of core clock genes (Bmal1, Rev-erbα, Rorα)...
October 17, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29039776/roles-of-aryl-hydrocarbon-receptor-in-aromatase-dependent-cell-proliferation-in-human-osteoblasts
#20
Yasuhiro Miki, Shuko Hata, Katsuhiko Ono, Takashi Suzuki, Kiyoshi Ito, Hiroyuki Kumamoto, Hironobu Sasano
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and its expression is influenced by environmental compounds, such as 3-methylcholanthrene (3-MC) and β-naphthoflavone (β-NF). AhR and its downstream genes, such as CYP1A1, are considered to play a pivotal role in xenobiotic responses. AhR signaling has also been proposed to mediate osteogenesis in experimental animals, but its details have remained unclear. Therefore, in this study, we examined the possible roles of AhR in human bone...
October 17, 2017: International Journal of Molecular Sciences
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