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Neuromodulation

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https://www.readbyqxmd.com/read/29053016/sudden-death-neurogenic-causes-prediction-and-prevention
#1
Nina Japundžić-Žigon, Olivera Šarenac, Maja Lozić, Marko Vasić, Tatjana Tasić, Dragana Bajić, Vladimir Kanjuh, David Murphy
Sudden death is a major health problem all over the world. The most common causes of sudden death are cardiac but there are also other causes such as neurological conditions (stroke, epileptic attacks and brain trauma), drugs, catecholamine toxicity, etc. A common feature of all these diverse pathologies underlying sudden death is the imbalance of the autonomic nervous system control of the cardiovascular system. This paper reviews different pathologies underlying sudden death with emphasis on the autonomic nervous system contribution, possibilities of early diagnosis and prognosis of sudden death using various clinical markers including autonomic markers (heart rate variability and baroreflex sensitivity), present possibilities of management and promising prevention by electrical neuromodulation...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29046924/liquid-chromatography-mass-spectrometry-with-triazole-bonded-stationary-phase-for-n-methyl-d-aspartate-receptor-related-amino-acids-development-and-application-in-microdialysis-studies
#2
Tatsuya Sakamoto, Riho Onuma, Shoko Furukawa, Akane Hayasaka, Mayu Onozato, Hiromi Nakazawa, Hideaki Iizuka, Hideaki Ichiba, Takeshi Fukushima
We aimed to monitor changes in the levels of amino acid neurotransmitters or neuromodulators simultaneously at the synaptic clefts of experimental animals. We developed a method for the simultaneous determination of the levels of amino acids, such as D-Ser, Gly, and L-Glu, which were involved in neurotransmission via the N-methyl-D-aspartate (NMDA) receptor, and other protein-constituted amino acids in a rat brain microdialysis (MD) sample. We used a liquid chromatography-mass spectrometry (LC-MS)/MS device equipped with a triazole-bonded column...
October 18, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29046305/neuromodulation-directed-at-the-prefrontal-cortex-of-subjects-with-obesity-reduces-snack-food-intake-and-hunger-in-a-randomized-trial
#3
Sascha Heinitz, Martin Reinhardt, Paolo Piaggi, Christopher M Weise, Enrique Diaz, Emma J Stinson, Colleen Venti, Susanne B Votruba, Eric M Wassermann, Miguel Alonso-Alonso, Jonathan Krakoff, Marci E Gluck
Background: Obesity is associated with reduced activation in the left dorsolateral prefrontal cortex (DLPFC), a region of the brain that plays a key role in the support of self-regulatory aspects of eating behavior and inhibitory control. Transcranial direct current stimulation (tDCS) is a noninvasive technique used to modulate brain activity.Objectives: We tested whether repeated anodal tDCS targeted at the left DLPFC (compared with sham tDCS) has an immediate effect on eating behavior during ad libitum food intake, resulting in weight change, and whether it might influence longer-term food intake-related appetite ratings in individuals with obesity...
October 18, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29044780/-hot-versus-cold-behavioral-cognitive-styles-motivational-dopaminergic-versus-cognitive-cholinergic-processing-of-a-pavlovian-cocaine-cue-in-sign-and-goal-tracking-rats
#4
Kyle K Pitchers, Louisa F Kane, Youngsoo Kim, Terry E Robinson, Martin Sarter
Discrete Pavlovian reward cues acquire more potent incentive motivational properties (incentive salience), in some animals (sign-trackers; STs) compared to others (goal trackers; GTs). Conversely, GTs appear to be better than STs in processing more complex contextual cues, perhaps reflecting their relatively greater bias for goal-directed cue processing. Here we investigated the activity of two major prefrontal neuromodulatory input systems, dopamine (DA) and acetylcholine (ACh), in response to a discrete Pavlovian cue that was previously paired with cocaine administration in STs and GTs...
October 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29043374/-overactive-bladder-which-treatment-when
#5
REVIEW
J Pannek
The term OAB (overactive bladder) describes a symptom complex. Therefore, initial treatment should be based on clinical symptoms and the results of basic diagnostics. Patient preference is essential for the choice of the initial treatment. Behavioural therapy, electrostimulation and medical treatment are available treatment options. If these are not effective, extended diagnostic examinations should be performed prior to minimally invasive treatments, like onabotulinumtoxin injections in the detrusor or sacral neuromodulation...
October 17, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29042433/serotonin-decreases-the-gain-of-visual-responses-in-awake-macaque-v1
#6
Lenka Seillier, Corinna Lorenz, Katsuhisa Kawaguchi, Torben Ott, Andreas Nieder, Paria Pourriahi, Hendrikje Nienborg
Serotonin (5HT) is an important neuromodulator in the brain implicated in affective and cognitive functions but its role even for basic cortical processes is controversial. For example, in the mammalian primary visual cortex heterogenous serotonergic modulation has been observed in anesthetized animals. Here, we combined extracellular single unit recordings with iontophoresis in awake animals. We examined the role of serotonin on well-defined tuning properties (orientation, spatial frequency, contrast and size) in the primary visual cortex (V1) of two male macaque monkeys...
October 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29042375/non-invasive-brain-stimulation-interventions-for-management-of-chronic-central-neuropathic-pain-a-scoping-review-protocol
#7
Mei Lin Chen, Lin Yao, Jennifer Boger, Kathryn Mercer, Benjamin Thompson, Ning Jiang
INTRODUCTION: Pain can affect people regardless of age, gender or ethnicity. Chronic central neuropathic pain (CCNP) is a debilitating condition that affects populations such as stroke survivors, amputees, spinal cord injury patients and patients with multiple sclerosis, with prevalence rates between 30% and 80%. This condition can be caused by a lesion or disease affecting the somatosensory system. CCNP is notoriously drug resistant, and few effective CCNP treatment or management strategies exist...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29037791/effect-of-optogenetic-modulation-on-entopeduncular-input-affects-thalamic-discharge-and-behavior-in-an-aav2-%C3%AE-synuclein-induced-hemiparkinson-rat-model
#8
Hyeong Cheol Moon, So Yoon Won, Eung Gook Kim, Hyong Kyu Kim, Chul Bum Cho, Young Seok Park
OBJECTIVE: Neuromodulation of the globus pallidus internus(GPi) alleviates Parkinson's disease symptoms. The primate GPi is homologous to the rat entopeduncular nucleus (EP). The aim of the present study was to determine if optogenetic modulation of the EP could alter parkinsonian behavior or thalamic discharge in a hemiparkinson rat model. METHODS: We injected an adeno-associated virus type-2 expressing α-synuclein (AAV2-α-syn) into the substantia nigra pars compacta (SNc) of the right hemisphere and confirmed parkinsonian behavior using an amphetamine-induced rotation test...
October 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29034542/time-frequency-analysis-of-increases-in-vaginal-blood-perfusion-elicited-by-long-duration-pudendal-neuromodulation-in-anesthetized-rats
#9
Indie C Rice, Lauren L Zimmerman, Shani E Ross, Mitchell B Berger, Tim M Bruns
OBJECTIVES: Female sexual dysfunction (FSD) affects a significant portion of the population. Although treatment options for FSD are limited, neuromodulation for bladder dysfunction has improved sexual function in some women. A few studies have investigated peripheral neuromodulation for eliciting changes in vaginal blood flow, as a proxy for modulating genital sexual arousal, however results are generally transient. Our central hypothesis is that repeated or extended-duration pudendal nerve stimulation can elicit maintained vaginal blood flow increases...
October 16, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29033856/possible-facilitative-effects-of-repeated-anodal-transcranial-direct-current-stimulation-on-functional-outcome-1-month-later-in-schizophrenia-an-open-trial
#10
Zui Narita, Takuma Inagawa, Kazuki Sueyoshi, Crystal Lin, Tomiki Sumiyoshi
Recent research on neuromodulation techniques, such as transcranial direct current stimulation (tDCS), for the treatment of schizophrenia has mainly focused on psychotic symptoms. We aimed to determine whether repetitive tDCS is efficacious in improving determinants of outcome, such as cognitive function, daily living skills, and depressive mood in patients with schizophrenia. Twenty-eight patients underwent tDCS (2 mA × 20 min) two times per day for 5 consecutive days. The anodal electrode was placed over the left dorsolateral prefrontal cortex while the cathodal electrode was placed over the right supraorbital region...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29033788/zinc-as-a-neuromodulator-in-the-central-nervous-system-with-a-focus-on-the-olfactory-bulb
#11
REVIEW
Laura J Blakemore, Paul Q Trombley
The olfactory bulb (OB) is central to the sense of smell, as it is the site of the first synaptic relay involved in the processing of odor information. Odor sensations are first transduced by olfactory sensory neurons (OSNs) before being transmitted, by way of the OB, to higher olfactory centers that mediate olfactory discrimination and perception. Zinc is a common trace element, and it is highly concentrated in the synaptic vesicles of subsets of glutamatergic neurons in some brain regions including the hippocampus and OB...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29031894/refractory-urgency-urinary-incontinence-treatment-in-women-impact-of-age-on-outcomes-and-complications
#12
Yuko M Komesu, Cindy L Amundsen, Holly E Richter, Stephen W Erickson, Mary F Ackenbom, Uduak U Andy, Vivian W Sung, Michael Albo, W Thomas Gregory, Marie Fidela Paraiso, Dennis Wallace
BACKGROUND: Women with refractory urgency urinary incontinence (UUI) (i.e. unresponsive to behavioral and pharmacologic interventions) are treated with onabotulinumtoxinA or sacral neuromodulation. OBJECTIVES: To compare treatment efficacy and adverse events (AEs) in women <65 and ≥65 years old treated with onabotulinumtoxinA or sacral neuromodulation (SNM). STUDY DESIGN: This study was a planned secondary analysis of a multi-center, randomized trial which enrolled community-dwelling women with refractory UUI to onabotulinumtoxinA or SNM treatments...
October 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29030173/a-novel-miniature-wireless-neurostimulator-in-the-management-of-chronic-craniofacial-pain-preliminary-results-from-a-prospective-pilot-study
#13
Richard L Weiner, Carlos Montes Garcia, Niek Vanquathem
OBJECTIVE: To report a novel wireless neuromodulation system for treatment of refractory craniofacial pain. BACKGROUND: Previous studies utilizing peripheral nerve stimulation (PNS) of the occipital and trigeminal nerves reported positive outcomes for alleviating neuropathic pain localized to the craniofacial and occipital areas. However several technological limitations and cosmetic concerns inhibited a more widespread acceptance and use of neuromodulation. Also, a relatively high incidence of adverse events like electrode erosions, dislocation, wire fracture and/or infection at the surgical site mandates a change in our approach to neuromodulation technology and implant techniques in the craniofacial region...
October 10, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29030111/double-blind-proof-of-concept-poc-trial-of-low-field-magnetic-stimulation-lfms-augmentation-of-antidepressant-therapy-in-treatment-resistant-depression-trd
#14
Maurizio Fava, Marlene P Freeman, Martina Flynn, Bettina B Hoeppner, Richard Shelton, Dan V Iosifescu, James W Murrough, David Mischoulon, Cristina Cusin, Mark Rapaport, Boadie W Dunlop, Madhukar H Trivedi, Manish Jha, Gerard Sanacora, Gretchen Hermes, George I Papakostas
BACKGROUND: Low-Field Magnetic Stimulation (LFMS) is a novel, non-invasive, sub-threshold neuromodulation technique, shown in preliminary studies to have immediate mood elevating effects in both unipolar and bipolar depressed patients. OBJECTIVE: We aimed to assess the antidepressant augmentation effects at 48 h of LFMS administered on two consecutive days compared to sham treatment in treatment resistant depression (TRD) subjects, using the Sequential Parallel Comparison Design (SPCD)...
September 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29029236/first-in-human-experience-with-complete-integration-of-neuromodulation-device-within-a-customized-cranial-implant
#15
Chad R Gordon, Gabriel F Santiago, Judy Huang, Gregory K Bergey, Shuya Liu, Mehran Armand, Henry Brem, William S Anderson
BACKGROUND: Neuromodulation devices have the potential to transform modern day treatments for patients with medicine-resistant neurological disease. For instance, the NeuroPace System (NeuroPace Inc, Mountain View, California) is a Food and Drug Administration (FDA)-approved device developed for closed-loop direct brain neurostimulation in the setting of drug-resistant focal epilepsy. However, current methods require placement either above or below the skull in nonanatomic locations. This type of positioning has several drawbacks including visible deformities and scalp pressure from underneath leading to eventual wound healing difficulties, micromotion of hardware with infection, and extrusion leading to premature explantation...
October 6, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29028858/approach-to-the-mature-cosmetic-patient-aging-gracefully
#16
Susan Weinkle, Michael Saco
<p>Aging gracefully has taken on a whole new meaning over the past few decades as new aesthetic treatments have been developed and are becoming more sophisticated by the day. The aging process, which is exacerbated by chronic UV exposure, results in dyspigmentation, loss of skin laxity, precancerous and cancerous skin lesions, fat loss and redistribution, and bone resorption. Laser and light devices can be used to treat dyspigmentation, while neuromodulators and soft tissue fillers can be used for rhytides and revolumization...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29026048/spinal-cord-stimulation-for-chronic-non-cancer-pain-a-review-of-current-evidence-and-practice
#17
S Sc Wong, C W Chan, C W Cheung
Spinal cord stimulation provides analgesia through electrical stimulation of the dorsal column of the spinal cord via electrode leads placed into the epidural space. In traditional tonic stimulation, a painful sensation is replaced with paraesthesia. Spinal cord stimulation is effective in reducing neuropathic pain, enhancing function, and improving quality of life in different chronic pain conditions. Currently, there is most evidence to support its use for failed back surgery syndrome when multidisciplinary conventional management is unsuccessful...
October 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29024871/brain-energetics-during-the-sleep-wake-cycle
#18
REVIEW
Mauro DiNuzzo, Maiken Nedergaard
Brain activity during wakefulness is associated with high metabolic rates that are believed to support information processing and memory encoding. In spite of loss of consciousness, sleep still carries a substantial energy cost. Experimental evidence supports a cerebral metabolic shift taking place during sleep that suppresses aerobic glycolysis, a hallmark of environment-oriented waking behavior and synaptic plasticity. Recent studies reveal that glial astrocytes respond to the reduction of wake-promoting neuromodulators by regulating volume, composition and glymphatic drainage of interstitial fluid...
October 9, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29024680/uridine-attenuates-morphine-induced-conditioned-place-preference-and-regulates-glutamate-gaba-levels-in-mpfc-of-mice
#19
Ping Liu, Xiaohang Che, Lisha Yu, Xiaofeng Yang, Nina An, Wu Song, Chunfu Wu, Jingyu Yang
Several lines of evidence suggest that uridine, as a neuromodulator, plays an important role in drug addiction. We previously found that uridine circumvents morphine-induced behavioral sensitization by decreasing the extracellular dopamine levels in the dorsal striatum. In the present study, the effects of uridine on morphine-induced conditioned place preference (CPP) and the possible roles of glutamate and GABA in the stress-induced reinstatement of CPP were investigated. First, the effects of uridine (1, 10 and 100mg/kg, i...
October 9, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29024483/neuromodulation-the-not-so-hidden-cure-for-the-opioid-crisis
#20
(no author information available yet)
No abstract text is available yet for this article.
October 2017: Neuromodulation: Journal of the International Neuromodulation Society
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