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Leydig cell toxicity

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https://www.readbyqxmd.com/read/28609275/effect-of-d-ribose-l-cysteine-on-aluminum-induced-testicular-damage-in-male-sprague-dawley-rats
#1
Benedict Falana, Opeyemi Adeleke, Mulikat Orenolu, Abraham Osinubi, Adeoye Oyewopo
OBJECTIVE: This study investigated the effects of D-ribose and L-cysteine on aluminum-induced testicular damage in male Sprague-Dawley rats. METHOD: A total number of thirty-five (35) adult male Sprague-Dawley rats were divided into four groups (AD). Group A (comprised five (5) rats) was designated the Control Group that received Physiological Saline; while groups B, C, and D (comprised ten (10) rats) were given 75 mg/kg, 150 mg/kg and 300 mg/kg of body weight of aluminum chloride respectively for 39 days...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28579575/prenatal-and-early-postnatal-noael-dose-clothianidin-exposure-leads-to-a-reduction-of-germ-cells-in-juvenile-male-mice
#2
Shogo Yanai, Tetsushi Hirano, Takuya Omotehara, Tadashi Takada, Naoki Yoneda, Naoto Kubota, Anzu Yamamoto, Youhei Mantani, Toshifumi Yokoyama, Hiroshi Kitagawa, Nobuhiko Hoshi
Neonicotinoids are pesticides used worldwide. They bind to insect nicotinic acetylcholine receptors (nAChRs) with high affinity. We previously reported that clothianidin (CTD), one of the latest neonicotinoids, reduced antioxidant expression and induced germ cell death in the adult testis of vertebrates. Here, we investigated the male reproductive toxicity of prenatal and early postnatal exposure to CTD, because it is likely that developmental exposure more severely affects the testis compared to adults due to the absence of the blood-testis barrier...
June 3, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28571864/inhibition-effects-of-perfluoroalkyl-acids-on-progesterone-production-in-mltc-1
#3
Wei Zhao, Ruina Cui, Jianshe Wang, Jiayin Dai
Perfluoroalkyl substances (PFASs) are a class of fluorine substituted carboxylic acid, sulfonic acid and alcohol, structurally similar to their corresponding parent compounds. Previous study demonstrated the potential endocrine disruption and reproductive toxicity of perfluorooctane sulfonic acid and perfluorooctanoic acid, two dominant PFASs in animals and humans. We explored the relationship between eleven perfluoroalkyl acids (PFAAs) with different carbon chain length and their ability to inhibit progesterone production in mouse Leydig tumor cells (mLTC-1)...
June 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28554659/naloxegol-an-opioid-antagonist-with-reduced-cns-penetration-mode-of-action-and-human-relevance-for-rat-testicular-tumours
#4
Håkan Andersson, Terri Mitchard, Nakpangi Johnson, Eike Floettmann
Naloxegol is an opioid antagonist which has been developed for the treatment of patients with opioid induced constipation. In the nonclinical safety program naloxegol was shown to have a very benign toxicity profile. In the rat, but not the mouse, 2-year carcinogenicity study a change in tumour pattern with an increase in testicular Leydig cell tumours (LCT) was observed after dosing at high (supra-pharmacological) concentrations. To establish the basis of the increase in LCT and to assess its potential relevance to humans, studies to exclude and potentially identify mode-of-action (MoA) were performed...
May 26, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28502228/the-toxic-effects-of-polychlorinated-biphenyl-aroclor-1242-on-tm3-leydig-cells
#5
Yasemin Aydin, Melike Erkan
Polychlorinated biphenyls (PCBs) are ubiquitous and persistent environmental contaminants that disrupt endocrine function in biological systems, especially in the male reproductive system. Previous studies on the reproductive toxicity of PCBs have focused on the impairment of spermatogenesis, disruption of steroidogenesis, decreased sperm number, and infertility. Aroclor 1242 is a commercial mixture with an average of 42% chlorine by weight. The purpose of the present study was to elucidate the hazardous effects of Aroclor 1242 on Leydig cells through an evaluation of cell viability, lipid peroxidation, hydroxyl radicals, H2O2 production, antioxidant enzymes, and steroidogenic enzymes...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28462439/ameliorative-effect-of-ve-igf-i-and-hcg-on-the-fluoride-induced-testosterone-release-suppression-in-mice-leydig-cells
#6
Yuxiang Yu, Yongli Han, Ruiyan Niu, Jundong Wang, Ram Kumar Manthari, Mohammad Mehdi Ommati, Zilong Sun
Excessive consumption of fluoride (F) through drinking, eating, and/or environmental contaminants induces chronic toxicity known as fluorosis. Our previous research has shown that fluorosis was associated with male reproductive disorders. The current study is designed to explain the protective effect of vitamin E (VE), insulin-like growth factor-I (IGF-I), and human chorionic gonadotropin (hCG) against natrium fluoride (NaF)-induced alterations in isolated Leydig cells (LCs). These NaF-induced alterations include decreased cell proliferation, steroidogenesis, and relative gene expression...
May 1, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28446800/oxidative-stress-evoked-damages-on-rat-sperm-and-attenuated-antioxidant-status-on-consumption-of-aspartame
#7
I Ashok, P S Poornima, D Wankhar, R Ravindran, R Sheeladevi
Although several studies on toxic effect of aspartame metabolite have been studied, controversial reports over the use of aspartame owing to the fact that it releases methanol as one of its metabolite during metabolism exist. This present study is proposed to investigate whether aspartame (40 mg kg(-1) b.wt) administration for 90 days could induce oxidative stress and alter antioxidant status of epididymal sperm in Wistar strain male albino rats. To mimic the human methanol metabolism, methotrexate (MTX)-treated rats were included to study the effects of aspartame...
April 27, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28441657/involvement-of-the-multidrug-and-toxic-compound-extrusion-transporter-in-testosterone-release-from-cultured-pig-leydig-cells
#8
Mitsuhiro Goda, Kana Oda, Atsuko Oda, Naoki Kobayashi, Masato Otsuka
Testosterone is considered to be released from Leydig cells via passive diffusion because of its hydrophobicity; however, the exact mechanism underlying testosterone secretion and the transporter involved are both unknown. Multidrug and toxic compound extrusion (MATE) transporters are predominantly found in the kidneys and liver and are thought to function in the elimination of metabolic organic cations during the final step of excretion in the kidney. In contrast, mMATE2 has been shown to be predominantly expressed in testicular Leydig cells...
2017: Pharmacology
https://www.readbyqxmd.com/read/28414027/arsenic-activates-the-expression-of-3%C3%AE-hsd-in-mouse-leydig-cells-through-repression-of-histone-h3k9-methylation
#9
Ambreen Alamdar, Guochen Xi, Qingyu Huang, Meiping Tian, Syed Ali Musstjab Akber Shah Eqani, Heqing Shen
Arsenic exposure has been associated with male reproductive dysfunction by disrupting steroidogenesis; however, the roles of epigenetic drivers, especially histone methylation in arsenic-induced steroidogenic toxicity remain not well documented. In this study, we investigated the role of histone H3 lysine 9 (H3K9) methylation in steroidogenesis disturbance in mouse Leydig cells (MLTC-1) due to arsenic exposure. Our results indicated that mRNA and protein expression levels of 3β-hydroxysteroid dehydrogenase (3β-HSD) were both significantly up-regulated while the rest of key genes involved in steroidogenesis were down-regulated...
July 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28395332/acetamiprid-inhibits-testosterone-synthesis-by-affecting-the-mitochondrial-function-and-cytoplasmic-adenosine-triphosphate-production-in-rat-leydig-cells%C3%A2
#10
Deying Kong, Jidong Zhang, Xiaohui Hou, Shibin Zhang, Jun Tan, Yuanshou Chen, Weirong Yang, Junwei Zeng, Yong Han, Xiaohong Liu, Delin Xu, Renlian Cai
The insecticide acetamiprid is used to control noxious agricultural pests. However, it can cause mammalian toxicity. We evaluated the reproductive toxicity of acetamiprid in adult male Sprague Dawley rats. Rats were given oral acetamiprid alone or with vitamin E for 35 days. Rat plasma testosterone concentration and sperm quality decreased significantly as the levels of luteinizing hormone (LH) increased after exposure. At the same time, acetamiprid increased malondialdehyde and nitric oxide (NO) levels of Leydig cells...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28393075/bisphenol-a-exposure-during-pregnancy-alters-the-mortality-and-levels-of-reproductive-hormones-and-genes-in-offspring-mice
#11
Shuang Ma, Wanyu Shi, Xiaodan Wang, Pengyan Song, Xiuhui Zhong
The present study investigated the reproductive toxicity of bisphenol A (BPA) exposure to the mother on the offspring mice. BPA was given to pregnant mice at 50 mg/kg, 500 mg/kg, and 2500 mg/kg BW BPA daily by gavage during the whole gestation period. The offspring mice were sacrificed at 8 weeks of age. Results showed that exposure of BPA to the mother increased the mortality (P < 0.05). Maternal exposure of BPA reduced the levels of T (♂) and FSH (♀) (P < 0.01) and elevated E2 (♀) level in the adult offspring (P < 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28339648/three-dimensional-testicular-organoid-a-novel-tool-for-the-study-of-human-spermatogenesis-and-gonadotoxicity-in-vitro%C3%A2
#12
Samuel S Pendergraft, Hooman Sadri-Ardekani, Anthony Atala, Colin E Bishop
Existing methods for evaluating the potential gonadotoxicity of environmental agents and pharmaceutical compounds rely heavily on animal studies. The current gold standard in vivo functional assays in animals are limited in their human predictive capacity. In addition, existing human two-dimensional in vitro models of testicular toxicity do not accurately reflect the in vivo situation. A more reliable testicular in vitro model system is needed to better assess the gonadotoxic potential of drugs prior to progression into clinical trials...
March 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28267506/inhibition-of-acrolein-induced-autophagy-and-apoptosis-by-a-glycosaminoglycan-from-sepia-esculenta-ink-in-mouse-leydig-cells
#13
Yi-Peng Gu, Xiao-Mei Yang, Ping Luo, Yan-Qun Li, Ye-Xing Tao, Zhen-Hua Duan, Wei Xiao, Da-Yan Zhang, Hua-Zhong Liu
In our recent reports, a squid ink polysaccharide (SIP) was found having preventive activity against cyclophosphamide induced damage in mouse testis and ovary. Here we further reveal the regulative mechanism of SIP against chemical toxicity on testis. Leydig cells exposed to acrolein (ACR) underwent apoptosis at 12h and 24h. Before apoptosis, cells occurred autophagy that was confirmed by high autophagic rate and Beclin-1 protein content at 3h. PI3K/Akt and p38 MAPK signal pathways involved in the regulatory mechanisms...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28250650/chronic-intake-of-green-propolis-negatively-affecting-the-rat-testis
#14
Grasiela Dias de Campos Severi-Aguiar, Suellen Josine Pinto, Cristina Capucho, Camila Andrea Oliveira, Maria Aparecida Diamante, Renata Barbieri, Fabrícia Souza Predes, Heidi Dolder
BACKGROUND: Human and animal evidence suggests that environmental toxicants may have an adverse impact on male reproductive health, reducing the population's reproductive output. Owing to the renewed attraction for natural products, some of them constitute effective alternatives to mitigate these effects. Propolis is a candidate for this use because of its intrinsic properties. In many situations, it improved the testicular damage and alleviated the toxic effects induced by environmental contaminant exposure...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28017703/prepubertal-subchronic-exposure-to-soy-milk-and-glyphosate-leads-to-endocrine-disruption
#15
Jessica Nardi, Patricia Bonamigo Moras, Carina Koeppe, Eliane Dallegrave, Mirna Bainy Leal, Luciana Grazziotin Rossato-Grando
Lactose intolerance is characterized by low or inexistent levels of lactase, and the main treatment consists of dietary changes, especially replacing dairy milk by soy milk. Soy contains phytoestrogens, substances with known estrogenic activity, besides, glyphosate-based herbicides are extensively used in soy crops, being frequently a residue in soy beans, bringing to a concern regarding the consumption of soy-based products, especially for children in breastfeeding period with lactose intolerance. This study evaluated the pubertal toxicity of a soy milk rich feeding (supplemented or not with glyphosate, doses of 50 and 100 mg/kg) during prepubertal period in male rats...
February 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28011299/apoptosis-inducing-factor-gene-depletion-inhibits-zearalenone-induced-cell-death-in-a-goat-leydig-cell-line
#16
Diqi Yang, Tingting Jiang, Pengfei Lin, Huatao Chen, Lei Wang, Nan Wang, Fan Zhao, Keqiong Tang, Dong Zhou, Aihua Wang, Yaping Jin
Zearalenone (ZEA) is a contaminant of human food and animal feedstuffs that causes health hazards. However, the signal pathways underlying ZEA toxicity remain elusive. The aims of this study were to determine which pathways are involved in ZEA-induced cell death and investigate the effect of apoptosis inducing factor (AIF) on cell death during ZEA treatment in the immortalized goat Leydig cell line hTERT-GLC. This study showed that ZEA-induced cell death in hTERT-GLCs works via endoplasmic reticulum (ER) stress, the caspase-dependent pathway, the caspase-independent pathway and autophagy...
December 20, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/28007637/reproductive-toxicity-of-linuron-following-gestational-exposure-in-rats-and-underlying-mechanisms
#17
Hongwei Ding, Wei Zheng, Hua Han, Xiyin Hu, Binli Hu, Feng Wang, Liyu Su, Hong Li, Yan Li
Linuron is a widely used herbicide in agriculture; its endocrine disruptive toxicity has recently received public attention. This study was designed to examine the developmental toxicity of linuron on the reproductive system of male offspring following maternal exposure. Mother rats received oral gavages of linuron, once daily, at the dose of 0, 50, 100, 150 or 200mg/kg, from gestational day (GD)13 to GD18; gonadal organs from GD20 fetuses were examined. Data indicated that exposed male offspring had a significantly shortened anogenital distance...
January 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28000947/a-potential-mechanism-associated-with-lead-induced-testicular-toxicity-in-rats
#18
M A El-Magd, K A Kahilo, N E Nasr, T Kamal, M Shukry, A A Saleh
This study was conducted to investigate the mechanism of lead (Pb)-induced testicular toxicity. We examined the impact of Pb toxicity on 17β-oestradiol (E2), oestrogen receptors (ERs) and aromatase P450 which are key factors in spermatogenesis. Treatment of rats with Pb acetate (PbAc, 50 mg/L in drinking water) significantly reduced sperm count, motility, viability and increased sperm abnormalities along with degenerative changes in seminiferous tubules and Leydig cells. Additionally, administration of PbAc resulted in a significant reduction in serum testosterone, serum and testicular E2 as well as increased level of testicular testosterone...
December 21, 2016: Andrologia
https://www.readbyqxmd.com/read/27984162/glycidamide-inhibits-progesterone-production-through-reactive-oxygen-species-induced-apoptosis-in-r2c-rat-leydig-cells
#19
Mingwei Li, Jianxia Sun, Feiyan Zou, Shun Bai, Xinwei Jiang, Rui Jiao, Shiyi Ou, Hui Zhang, Zhijian Su, Yadong Huang, Weibin Bai
The food contaminant acrylamide (AA) is usually recognized as a probable human carcinogen. In addition, AA has also been found able to induce male infertility in animals. Interestingly, resent research work revealed that the toxic effect of AA on the ability of male reproduction in vivo may due to glycidamide (GA) which is the metabolite of AA. In this study, R2C Leydig cells was used to investigate the toxic effects of GA on progesterone production. GA caused dose-dependent inhibition on the cell growth, with IC25, IC50, and IC75 values found at 0...
October 27, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27884059/dna-methylation-analysis-in-rat-kidney-epithelial-cells-exposed-to-3-mcpd-and-glycidol
#20
Mine Senyildiz, Buket Alpertunga, Sibel Ozden
3-Monochloropropane-1,2-diol (3-MCPD) is a well-known food processing contaminant that has been regarded as a rat carcinogen, which is known to induce Leydig-cell and mammary gland tumors in males, as well as kidney tumors in both genders. 3-MCPD is highly suspected to be a non-genotoxic carcinogen. 2,3-Epoxy-1-propanol (glycidol) can be formed via dehalogenation from 3-MCPD. We aimed to investigate the cytotoxic effects of 3-MCPD and glycidol, then to demonstrate the possible epigenetic mechanisms with global and gene-specific DNA methylation in rat kidney epithelial cells (NRK-52E)...
November 24, 2016: Drug and Chemical Toxicology
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