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Leydig cell

Tolga Mercantepe, Deniz Unal, Levent Tümkaya, Zihni Acar Yazici
Cisplatin is an effective antineoplastic drug that is usually used to treat a number of different types of cancer in the clinic. One of the most notable side effects of cisplatin use is infertility. The present study was designed to determine the non-oxidative testicular effects caused by the use of cisplatin in rats. The rats were randomly allocated to the experimental groups. The untreated rats represented the control group (group I) and the treatment groups were as follows: cisplatin alone (group II), cisplatin+amifostine (group III), cisplatin+curcumin (group IV), and cisplatin+caffeic acid phenethyl ester (CAPE; group V)...
April 2018: Experimental and Therapeutic Medicine
Kays Chaker, Ahmed Sellami, Yassine Ouanes, Mohamed Ali Ben Chehida, Mokhtar Bibi, Mahdi Krarti, Karem Abid, Sami Ben Rhouma, Yassine Nouira
No abstract text is available yet for this article.
March 2018: Urology Case Reports
Pia Paffenholz, Linn Held, Sven H Loosen, David Pfister, Axel Heidenreich
PURPOSE: Small benign testicular masses are often misinterpreted as germ cell tumors, and immediate inguinal orchiectomy is performed. We aimed to analyse the diagnostic and therapeutic work-up of testicular masses in order to improve preoperative stratification algorithms. MATERIALS AND METHODS: We performed a retrospective, single-center analysis of 522 patients diagnosed with primary testicular masses of unknown malignant potential. RESULTS: 28 (5%) patients showed a primary benign tumor after resection: 9 (32%) Leydig cell tumors, 9 (32%) epidermoid cysts, 8 (29%) adenomatoid tumors and 2 (7%) Sertoli cell tumors...
March 9, 2018: Journal of Urology
B Güney Saruhan, H Sağsöz, E Akbalık, M A Ketani, S Erdoğan
The mammalian testis possesses a special immunological environment because of its properties of remarkable immune privilege and effective local innate immunity. The testicular immune privilege protects immunogenic germ cells from systemic immune attack, and local innate immunity is important in preventing testicular microbial infections. Thus, this study aimed to immunohistochemically demonstrate the distribution and localization of CD68-, CD8-, MHCI- and MHCII-positive immune cells in the testes and epididymes...
March 12, 2018: Anatomia, Histologia, Embryologia
Nicholas H Chakirya, Phil W Raess, Kevin Turner, Jason C Hedges, Jen-Jane Liu
Malignant Leydig cell tumor is a rare entity that has been previously described as rapidly progressive and uniformly fatal. We present the case of a malignant Leydig cell tumor that presented 14 years after orchiectomy with an isolated retroperitoneal metastasis. Our patient underwent a retroperitoneal lymph node dissection and has been free of recurrence or progression at 12 months of follow up. Additionally, we describe the symptomatic hormone dysfunction experienced by our patient as a result of his tumor...
February 2018: Canadian Journal of Urology
Lanlan Chen, Yu Zhao, Linchao Li, Lubin Xie, Xianwu Chen, Jianpeng Liu, Xiaoheng Li, Lixu Jin, Xingwang Li, Ren-Shan Ge
Bisphenol A (BPA) is widely used in consumer products and a potential endocrine disruptor linked with sexual precocity. However, its action and underlying mechanisms on male sexual maturation is unclear. In the present study, we used a unique in vivo ethane dimethane sulfonate (EDS)-induced Leydig cell regeneration model that mimics the pubertal development of Leydig cells and an in vitro stem Leydig cell differentiation model to examine the roles of BPA in Leydig cell development in rats. Intratesticular exposure to doses (100 and 1000 pmol/testis) of BPA from post-EDS day 14-28 stimulated Leydig cell developmental regeneration process by increasing serum testosterone level and Leydig cell-specific gene (Lhcgr, Star, Cyp11a1, Hsd3b1, Cyp17a1, Hsd17b3, and Hsd11b1) and their protein expression levels...
March 7, 2018: Molecular and Cellular Endocrinology
Carolina Mondillo, María Luisa Varela, Adriana María Belén Abiuso, Ramiro Vázquez
Histamine (HA) is a pleiotropic biogenic amine synthesized exclusively by histidine decarboxylase (HDC) in most mammalian tissues. The literature on the role of HA within the male gonad has expanded over the last years, attracting attention to potential unexpected side-effects of anti-histamines on testicular function. In this regard, HA receptors (HRH1, HRH2 and HRH4) have been described in Leydig cells of different species, including human. Via these receptors, HA has been reported to trigger positive or negative interactions with the LH/hCG signaling pathway depending upon its concentration, thereby contributing to the local control of testicular androgen levels...
March 9, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Min Chen, Weibin Zhou, Zhe Zhang, Yuting Zou, Chengjiang Li
RATIONALE: The incidence of severe hyperandrogenism associated with masculinity in women is very low. While rare and difficult to diagnose, androgen secreting tumors should be suspected in women with hyperandrogenism and hirsutism, especially in the postmenopausal population. Herein we present one case of ovarian Leydig cell tumor (LCT) with markedly elevated serum testosterone levels and frank hirsutism. PATIENT CONCERNS: A 60-year-old woman, presented with increased hair growth and androgenic alopecia and the hormonal laboratory examination showed that she had elevated serum testosterone level and normal dehydroepiandrosterone sulfate (DHEAS), androstenedione, 17- hydroxyprogesterone, cortisol and thyroid stimulating hormone (TSH)...
March 2018: Medicine (Baltimore)
Dong-Mei Su, Ying Feng, Lin Wang, Yi-Lun Wu, Ren-Shan Ge, Xue Ma
Leydig cells are the main endogenous testosterone synthesis cells in the body. Testosterone is an essential hormone in males that affects metabolism, emotion, and pubertal development. However, little is known about the development of Leydig cells and relationship between fetal Leydig cells (FLCs) and adult Leydig cells (ALCs). The aims of this study were to investigate the effect of (FLCs) on ALC development. Our study showed that FLCs in neonatal rat testis can be eliminated by 100 mg/kg ethane dimethane sulfonate (EDS) treatment without affecting the health of newborn rats...
March 6, 2018: Journal of Reproduction and Development
Mikkel Andreassen, Anders Juul, Ulla Feldt-Rasmussen, Niels Joergensen
Gonadotropins (luteinizing hormone (LH) and follicle stimulating hormone (FSH)) are released from the pituitary gland and stimulate Leydig cells to produce testosterone and initiates spermatogenesis. Little is known about how and when the deterioration of semen quality occurs in patients with adult onset gonadotropin insufficiency Design and methods: A retrospective study comprising 20 testosterone deficient men (median age 29 years) with acquired pituitary disease, who delivered semen for cryopreservation before initiation of testosterone therapy...
March 7, 2018: Endocrine Connections
TaeSun Min, Ki-Ho Lee
Objective: Nandrolone decanoate (ND) is an anabolic-androgenic steroid frequently used for clinical treatment. However, the inappropriate use of ND results in the reduction of serum testosterone level and sperm production. The suppressive effect of ND on testosterone production has not been investigated in detail. The present study was designed to examine the effect of ND on the expression of steroidogenic enzymes in the rat testis. Methods: Male Sprague Dawley rats at 50 days of age were subcutaneously administrated with either 2 or 10 mg of ND/kg body weight/week for 2 or 12 weeks...
March 2, 2018: Asian-Australasian Journal of Animal Sciences
M Ren, X F Cong, S S Zhao, Y Zhang, L Yang
No abstract text is available yet for this article.
February 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Zaina S Inam, Abdul Hussain Azizi, Soemiwati W Holland
Sertoli-Leydig cell tumour (SLCT) is a rare, androgen-secreting sex cord-stromal tumour of the ovary that usually occurs in young premenopausal women. The major clinical manifestations are virilisation and defeminisation. The following case describes an 88-year-old G1P1 woman, 40 years after menopause, who presented with flushing, hirsutism, voice changes and alopecia along with significantly elevated levels of testosterone. Postoperative report revealed a well-differentiated SLCT in the left ovary. This case is unique in that SLCT is a very rare cancer and even more so in an 88-year-old woman...
March 1, 2018: BMJ Case Reports
Surang Chomphoo, Sawetree Pakkarato, Tarinee Sawatpanich, Hiroyuki Sakagami, Hisatake Kondo, Wiphawi Hipkaeo
EFA6 (exchange factor for ARF6) activates Arf6 (ADP ribosylation factor 6) by exchanging ADP to ATP and the resulting activated form of Arf6 is involved in the membrane trafficking and actin remodeling of cells. Our previous study has shown the selective expression/localization of EFA6D in steroidogenic adrenocortical cells in situ of adult mice. In view of the previous finding, the present study was undertaken to examine its localization in mouse Leydig cells representing another steroidogenic cell species in order to further support the possible involvement of the EFA6/Arf6 cascade via membrane trafficking in the regulation of steroidogenesis and/or secretion...
February 26, 2018: Acta Histochemica
Hamid Rashtbari, Mazdak Razi, Hassan Hassani-Bafrani, Hamed Najaran
BACKGROUND: Varicocele is present in 10-20% of the male infertile population. PURPOSE: Present study was done to demonstrate the reinforcing effect of berberine (BBR), as an antioxidant and anti-inflammatory agent, on Sertoli cells-related niche and spermatogonial stem cells (SSCs) self-renewal in experimentally-induced VCL condition. STUDY DESIGN: 50 mature male Wistar rats were divided into control, control-sham, non-treated VCL-induced, 50 mg kg-1 and 100 mg kg-1 BBR-treated VCL-induced groups...
February 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Gang Bai, Bin Yang, Weimin Tong, Hongjun Li
The effect of hypoxia on the spermatogenesis of male Wistar rats (n = 32) at pre-puberty was studied using a hypobaric chamber simulating an altitude of 5,000 metres above sea level. Persistent hypoxic exposure with brief interruption for 3 weeks caused significant decreases in body and testis weights and testosterone level compared to the normobaric controls. Histologically, spermatogenic development was arrested; arrays of spermatids were misshaped; numbers of spermatogonia, Sertoli and Leydig cells were reduced; and apoptotic spermatocytes were increased substantially in the germinal epithelium of testis in the hypoxic-exposed group...
February 27, 2018: Andrologia
Giovanna Liguori, Caterina Squillacioti, Loredana Assisi, Alessandra Pelagalli, Alfredo Vittoria, Anna Costagliola, Nicola Mirabella
BACKGROUND: Cryptorchidism is one of the most common birth disorders of the male reproductive system identified in dogs and other mammals. This condition is characterised by the absence of one (unilateral) or both (bilateral) gonads from the scrotum. The peptides orexin A (OxA) and B (OxB) were obtained by post-transcriptional proteolytic cleavage of a precursor molecule, called prepro-orexin. These substances bind two types of G-coupled receptors called receptor 1 (OX1R) and 2 (OX2R) for orexins...
February 27, 2018: BMC Veterinary Research
Lei Zhihai
Neuropeptide B (NPB) is an endogenous ligand for the orphan G protein-coupled receptors NPBWR1 (GPR7) and NPBWR2 (GPR8). Some reports have investigated the role of NPB in the regulation of feeding, energy metabolism and hormone secretion in many species. However, few papers reported the physiological function of NPB in the pig. In this study, we cloned and sequenced the NPB mRNA from a pig, which was found to consist of 123 bases. NPB mRNA expression was detected in central and peripheral tissues by the quantitative fluorescence method...
February 23, 2018: General and Comparative Endocrinology
B Zhang, W Ma, Q Zhu, W Xu, L Gao, B Xu, S Xu, C Gao, L Gao, J Liu, Y Cui
Approximately 40% of middle-aged men exhibit symptoms of late-onset hypogonadism (LOH). However, the mechanism of androgen deficiency is still currently unclear. As shown in our previous studies, the SET protein is expressed in testicular Leydig cells and ovarian granule cells. This study was designed to investigate the effect of the SET protein on androgen production in Leydig cells. The AdCMV/SET and AdH1siRNA/SET adenoviruses were individually transduced into a cultured mouse Leydig cell line (mLTC-1) with or without human chorionic gonadotropin (HCG) stimulation in vitro...
February 26, 2018: Andrology
Hui Gao, Chao Liu, Wei Li
Autophagy is an important intracellular degradation system which is implicated in many physiological and pathological processes. During autophagy, cytosolic constituents such as organelles and macromolecules are engulfed by autophagosome, and then they fuse with lysosomes for degradation and recycle of the engulfed components within the autolysosome to maintain cellular homeostasis. In male testis, the Leydig cells provide the major source of testosterone production. Autophagy is extremely active in Leydig cells and is involved in the steroid production...
February 27, 2018: Methods in Molecular Biology
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