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https://www.readbyqxmd.com/read/27915366/aging-has-the-opposite-effect-on-camp-and-cgmp-circadian-variations-in-rat-leydig-cells
#1
Aleksandar Z Baburski, Srdjan J Sokanovic, Silvana A Andric, Tatjana S Kostic
The Leydig cell physiology displays a circadian rhythm driven by a complex interaction of the reproductive axis hormones and circadian system. The final output of this regulatory process is circadian pattern of steroidogenic genes expression and testosterone production. Aging gradually decreases robustness of rhythmic testosterone secretion without change in pattern of LH secretion. Here, we analyzed effect of aging on circadian variation of cAMP and cGMP signaling in Leydig cells. Results showed opposite effect of aging on cAMP and cGMP daily variation...
December 3, 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/27906793/multimorbidity-and-genetic-characteristics-of-dicer1-syndrome-based-on-systematic-review
#2
Siyu Cai, Wen Zhao, Xiaolu Nie, Ali Abbas, Libing Fu, Safaa Bihi, Guoshuang Feng, Tianyi Liu, Yaqi Lv, Xiaoli Ma, Xiaoxia Peng
It has been reported that germline DICER1 mutations correlate with a distinctive human disease syndrome. Many published studies within this field have been conducted based on rare cases. We systematically searched bibliographic databases, including PubMed, Embase, and COSMIC for articles which are related to diseases covered by DICER1 syndrome. The weighted summary of mutation frequencies among patients with pleuropulmonary blastoma (PPB), cystic nephroma (CN), and Sertoli-Leydig cell tumor (SLCT) were calculated...
November 30, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27901643/bilateral-testicular-tumors-resulting-in-recurrent-cushing-s-syndrome-after-bilateral-adrenalectomy
#3
Troy Puar, Manon Engels, Antonius E van Herwaarden, Fred C G J Sweep, Christina Hulsbergen-van de Kaa, Karin Kamphuis-van Ulzen, Vasileios Chortis, Wiebke Arlt, Nike Stikkelbroeck, Hedi L Claahsen-van der Grinten, Ad R M M Hermus
CONTEXT: Recurrence of hypercortisolism in patients after bilateral adrenalectomy for Cushing's disease is extremely rare. PATIENT: We present a rare case of a 27-year-old man who previously underwent bilateral adrenalectomy for Cushing's disease with complete clinical resolution. Cushingoid features recurred 12 years later, along with bilateral testicular enlargement. Hormonal tests confirmed ACTH-dependent Cushing's. Surgical resection of the testicular tumors led to clinical and biochemical remission...
November 30, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27896549/embryonal-rhabdomyosarcoma-in-a-patient-with-a-heterozygous-frameshift-variant-in-the-dicer1-gene-and-additional-manifestations-of-the-dicer1-syndrome
#4
Julia Fremerey, Stefan Balzer, Triantafyllia Brozou, Joerg Schaper, Arndt Borkhardt, Michaela Kuhlen
Germline mutations in the DICER1 gene are associated with an inherited cancer predisposition syndrome also known as the DICER1-syndrome, which is implicated in a broad range of tumors including pleuropulmonary blastoma, ovarian Sertoli-Leydig cell tumors, ciliary body medulloepithelioma (CBME), pituitary blastoma, embryonal rhabdomyosarcoma (eRMS), anaplastic renal sarcoma as well as ocular, sinonasal tumors ovarian sex-cord tumors, thyroid neoplasia and cystic nephroma. This study describes a novel, heterozygous frameshift DICER1 mutation in a patient, who is affected by different tumors of the DICER1-syndrome, including eRMS, CBME and suspected pleuropulmonary blastoma type I...
November 28, 2016: Familial Cancer
https://www.readbyqxmd.com/read/27892862/melamine-negatively-affects-testosterone-synthesis-in-mice
#5
Jiarui Sun, Yinan Cao, Xinchen Zhang, Qiling Zhao, Endong Bao, Yingjun Lv
Several studies have found that melamine causes damage to the testes, epididymis and sperm. However, few studies have investigated the effect of melamine on the synthesis of testosterone, which plays an import role in testicular development and spermatogenesis. In present study, mice were orally administrated with 2, 10 or 50mg/kg of melamine for 28days. In these groups, various abnormalities were observed including disruption of the seminiferous tubule structure, an increased necrotic germ cells and sperm abnormalities, and a reduced sperm count...
October 13, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27890492/treatment-of-leydig-cell-tumours-of-the-testis-can-testis-sparing-surgery-replace-radical-orchidectomy-results-of-a-systematic-review
#6
G Bozzini, D Ratti, L Carmignani
INTRODUCTION: The gold standard for Leydig cell tumours (LCTs) is still considered radical orchidectomy, but testis sparing surgery (TSS) in conjunction with intraoperative frozen section (FSE) has been recently attempted with promising results. ACQUISITION OF EVIDENCE: Studies were identified by searching electronic databases. A bibliographic search covering the period from January 1980 to December 2012 was conducted using PubMed/MEDLINE and EMBASE database. Studies were excluded if they were single case reports, meeting abstracts and conference proceedings...
November 24, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27888191/wt1-directs-the-lineage-specification-of-sertoli-and-granulosa-cells-by-repressing-sf1-expression
#7
Min Chen, Lianjun Zhang, Xiuhong Cui, Xiwen Lin, Yaqiong Li, Yaqing Wang, Yanbo Wang, Yan Qin, Dahua Chen, Chunsheng Han, Bin Zhou, Vicki Huff, Fei Gao
Supporting cells (Sertoli and granulosa) and steroidogenic cells (Leydig and theca-interstitium) are two major somatic cell types in mammalian gonads. However, the mechanisms that control their differentiation during gonad development remain elusive. In this study, we found deletion of Wt1 in ovary after sex determination caused ectopic development of steroidogenic cells at embryonic stage. Furthermore, the differentiation of both Sertoli and granulosa cells was blocked when Wt1 was deleted before sex determination and most genital ridge somatic cells differentiated into steroidogenic cells in both male and female gonads...
November 25, 2016: Development
https://www.readbyqxmd.com/read/27886378/interactive-effect-of-corticosterone-and-lactate-on-regulation-of-testosterone-production-in-rat-leydig-cells
#8
Chih-Chieh Chen, Chien-Wei Chen, Po-Han Lin, Jou-Chun Chou, Ting-Chun Weng, Cai-Yun Jian, Sindy Hu, Wei-Ho Lai, Fu-Kong Lieu, Shyi-Wu Wang, Paulus S Wang
The increasing intensity of exercise enhanced corticosterone and lactate production in both humans and rodents. Our previous studies also demonstrated that lactate could stimulate testosterone production in vivo and in vitro. However, the production of testosterone in response to combined corticosterone and lactate on Leydig cells, and underlying molecular mechanisms are remained unclear. This study investigated the changes in testosterone levels of Leydig cells upon exposure to lactate, corticosterone or combination of both, and revealed the detailed mechanisms...
November 25, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27885054/impact-of-uteroplacental-insufficiency-on-postnatal-rat-male-gonad
#9
Valentina Pampanini, Daniela Germani, Antonella Puglianiello, Jan-Bernd Stukenborg, Ahmed Reda, Iuliia Savchuk, Kristin Ros Kjartansdóttir, Stefano Cianfarani, Olle Soder
BACKGROUND: Prenatal events such as intrauterine growth restriction can affect gonadal development of the offspring and have an impact on reproductive health. PURPOSE: To investigate the effects of intrauterine growth restricted induced by uterine artery ligation on the postnatal rat testis. METHODS: Pregnant rats underwent uterine artery ligation at day 19 of gestation. Offspring were sacrificed at 5, 20 and 40 days post-partum (dpp). At sacrifice, one gonad was snap frozen in liquid nitrogen and processed for RNA and steroid extraction...
November 24, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27884405/zika-virus-causes-testis-damage-and-leads-to-male-infertility-in-mice
#10
Wenqiang Ma, Shihua Li, Shuoqian Ma, Lina Jia, Fuchun Zhang, Yong Zhang, Jingyuan Zhang, Gary Wong, Shanshan Zhang, Xuancheng Lu, Mei Liu, Jinghua Yan, Wei Li, Chuan Qin, Daishu Han, Chengfeng Qin, Na Wang, Xiangdong Li, George Fu Gao
Zika virus (ZIKV) persists in the semen of male patients, a first for flavivirus infection. Here, we demonstrate that ZIKV can induce inflammation in the testis and epididymidis, but not in the prostate or seminal vesicle, and can lead to damaged testes after 60 days post-infection in mice. ZIKV induces innate immune responses in Leydig, Sertoli, and epididymal epithelial cells, resulting in the production of pro-inflammatory cytokines/chemokines. However, ZIKV does not induce a rapid and abundant cytokine production in peritubular cell and spermatogonia, suggesting that these cells are vulnerable for ZIKV infection and could be the potential repositories for ZIKV...
December 1, 2016: Cell
https://www.readbyqxmd.com/read/27884059/dna-methylation-analysis-in-rat-kidney-epithelial-cells-exposed-to-3-mcpd-and-glycidol
#11
Mine Senyildiz, Buket Alpertunga, Sibel Ozden
3-Monochloropropane-1,2-diol (3-MCPD) is a well-known food processing contaminant that has been regarded as a rat carcinogen, which is known to induce Leydig-cell and mammary gland tumors in males, as well as kidney tumors in both genders. 3-MCPD is highly suspected to be a non-genotoxic carcinogen. 2,3-Epoxy-1-propanol (glycidol) can be formed via dehalogenation from 3-MCPD. We aimed to investigate the cytotoxic effects of 3-MCPD and glycidol, then to demonstrate the possible epigenetic mechanisms with global and gene-specific DNA methylation in rat kidney epithelial cells (NRK-52E)...
November 24, 2016: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/27876458/relative-abundance-of-g-protein-coupled-receptor-30-and-localization-in-testis-and-epididymis-of-sheep-at-different-developmental-stages
#12
Peiyao Lu, Fuchuan Wang, Xianyi Song, Yang Liu, Kai Zhang, Ningxian Cao
The G protein-coupled receptor 30 (GPR30) is a transmembrane estrogen receptor that binds to estrogen, and has been confirmed to have an important role in testicular cell proliferation and development. The main objective of this study was to examine GPR30 gene expression and localization in the testis and epididymis of sheep at different developmental stages. Testes, including the epididymis, were collected from Polled Dorset x Mongolian cross rams at one (n=4; wt), three (n=4; wt), six (n=4; wt), nine (n=4; wt) and 12 (n=4; wt) months of age...
December 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27869164/the-hot-spot-p53r172h-mutant-promotes-formation-of-giant-spermatogonia-triggered-by-dna-damage
#13
Y Xue, A Raharja, W Sim, E S M Wong, S A B Rahmat, D P Lane
Overexpression of mutant p53 is a common finding in most cancers but testicular tumours accumulate wild-type p53 (wtp53). In contrast to the accepted concept that p53 homozygous mutant mice do not accumulate mutant p53 in normal cells, our study on a mutant p53 mouse model of Li-Fraumeni syndrome harbouring the hot-spot p53R172H mutation described an elevated level of mutant p53 in non-cancerous mouse tissues. Here we use detailed immunohistochemical analysis to document the expression of p53R172H in mouse testis...
November 21, 2016: Oncogene
https://www.readbyqxmd.com/read/27867356/cyanidin-3-o-glucoside-protects-against-1-3-dichloro-2-propanol-induced-reduction-of-progesterone-by-up-regulation-of-steroidogenic-enzymes-and-camp-level-in-leydig-cells
#14
Jianxia Sun, Wei Xu, Cuijuan Zhu, Yunfeng Hu, Xinwei Jiang, Shiyi Ou, Zhijian Su, Yadong Huang, Rui Jiao, Weibin Bai
1,3-Dichloro-2-propanol (1,3-DCP) is a food processing contaminant and has been shown to perturb male reproductive function. Cyanidin-3-O-glucoside (C3G), an anthocyanin antioxidant, is reported to have protective effects on many organs. However, it remains unclear whether C3G protects against chemical-induced reproductive toxicity. The present study was therefore to investigate the intervention of C3G on 1,3-DCP-induced reproductive toxicity in R2C Leydig cells. Results demonstrated that C3G inhibited the 1,3-DCP-induced cytotoxicity and cell shape damage with the effective doses being ranging from 10 to 40 μmol/L...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27867114/serine-protease-inhibitor-kazal-type-2-is-expressed-in-the-male-reproductive-tract-of-carp-with-a-possible-role-in-antimicrobial-protection
#15
Mariola A Dietrich, Mariola Słowińska, Halina Karol, Mikołaj Adamek, Dieter Steinhagen, Anna Hejmej, Barbara Bilińska, Andrzej Ciereszko
The presence of the low-molecular-mass serine protease inhibitor Kazal-type (Spink) is a characteristic feature of vertebrate semen. Its main function is control of the serine protease in the acrosome, acrosin. Here we showed for the first time that Spink is present in the seminal plasma of carp, which have anacrosomal spermatozoa. Using a three-step isolation procedure that consisted in gel filtration and RP-HPLC and re-RP-HPLC, we isolated this inhibitor and identified it as serine protease inhibitor Kazal-type 2 (Spink2), a reproductive-derived member of the Spink family...
November 17, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27860441/effects-of-human-chorionic-gonadotropin-on-testicular-interstitial-tissues-in-men-with-non-obstructive-azoospermia
#16
S Oka, K Shiraishi, H Matsuyama
Non-obstructive azoospermia is a severe condition because spermatogenesis per se is disrupted. Although microdissection testicular sperm extraction is the standard therapy for non-obstructive azoospermia, sperm retrieval is unsuccessful in approximately 50% of patients. For these patients, we conducted human chorionic gonadotropin-based salvage hormonal therapy, and sperm retrieval was possible in 10-20% of patients. The objectives of this study were to assess the changes in interstitial lesions in patients with non-obstructive azoospermia and to evaluate the effects of human chorionic gonadotropin on these tissues...
November 16, 2016: Andrology
https://www.readbyqxmd.com/read/27858560/ovarian-sex-cord-stromal-tumors
#17
Kris Ann P Schultz, Anne K Harris, Dominik T Schneider, Robert H Young, Jubilee Brown, David M Gershenson, Louis P Dehner, D Ashley Hill, Yoav H Messinger, A Lindsay Frazier
Ovarian sex cord-stromal tumors are clinically significant heterogeneous tumors that include several pathologic types. These tumors are often found in adolescents and young adults and can present with hormonal manifestations as well as signs and symptoms of a pelvic mass. Serum tumor markers may assist in preoperative diagnosis and surveillance. Several subtypes are associated with genetic predisposition, including those observed in patients with Peutz-Jegher syndrome. Recent studies have elucidated the relationship between Sertoli-Leydig cell tumors and DICER1 mutations...
October 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27849668/risk-of-acute-testicular-failure-after-preoperative-radiotherapy-for-rectal-cancer-a-prospective-cohort-study
#18
Christian Buchli, Anna Martling, Massoud Al Abani, Jan-Erik Frödin, Matteo Bottai, Ingmar Lax, Stefan Arver, Torbjörn Holm
OBJECTIVE: The aim of this study was to assess the acute effect of preoperative RT for rectal cancer on endocrine testicular function. BACKGROUND: Preoperative radiotherapy (RT) enhances local control and cancer-specific survival in patients treated for rectal cancer. In case series, a negative acute effect on Leydig cell function has been reported. METHODS: This prospective cohort study included 168 males with rectal or prostate cancer stage I-III...
November 15, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27845131/re-compensated-reduction-in-leydig-cell-function-is-associated-with-lower-semen-quality-variables-a-study-of-8182-european-young-men
#19
Craig Niederberger
No abstract text is available yet for this article.
December 2016: Journal of Urology
https://www.readbyqxmd.com/read/27842451/toxicity-and-oxidative-stress-induced-by-t-2-toxin-in-cultured-mouse-leydig-cells
#20
Yong Fa Zhang, Jian Ying Yang, Yong Kai Li, Wei Zhou
To explore the toxic mechanism of T-2 toxin on Leydig cells of mice, we would investigate the toxicity and oxidative stress induced by T-2 toxin in the cells. Leydig cells were isolated and cultured with control or T-2 toxin (10(-7) M, 10(-8) M, or 10(-9) M) for 24 h, then cells and supernatants were harvested to examine cell viability, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities, expression of messenger RNA (mRNA) related to oxidative stress, malondialdehyde (MDA) content and DNA damage...
November 29, 2016: Toxicology Mechanisms and Methods
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