keyword
MENU ▼
Read by QxMD icon Read
search

Leydig cell

keyword
https://www.readbyqxmd.com/read/28333300/comparison-of-global-gene-expression-profiles-of-microdissected-human-foetal-leydig-cells-with-their-normal-and-hyperplastic-adult-equivalents
#1
Grete Lottrup, Kirstine Belling, Henrik Leffers, John E Nielsen, Marlene D Dalgaard, Anders Juul, Niels E Skakkebæk, Søren Brunak, Ewa Rajpert-De Meyts
STUDY QUESTION: Do human adult Leydig cells (ALCs) within hyperplastic micronodules display characteristics of foetal LCs (FLCs)? SUMMARY ANSWER: The gene expression profiles of FLCs and all ALC subgroups were clearly different, but there were no significant differences in expressed genes between the normally clustered and hyperplastic ALCs. WHAT IS KNOWN ALREADY: LCs are the primary androgen producing cells in males throughout development and appear in chronologically distinct populations; FLCs, neonatal LCs and ALCs...
March 17, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28329024/toward-developing-recombinant-gonadotropin-based-hormone-therapies-for-increasing-fertility-in-the-flatfish-senegalese-sole
#2
François Chauvigné, Judith Ollé, Wendy González, Neil Duncan, Ignacio Giménez, Joan Cerdà
Captive flatfishes, such as the Senegalese sole, typically produce very low volumes of sperm. This situation is particularly prevalent in the first generation (F1) of reared sole males, which limits the development of artificial fertilization methods and the implementation of selective breeding programs. In this study, we investigated whether combined treatments with homologous recombinant follicle-stimulating (rFsh) and luteinizing (rLh) hormones, produced in a mammalian host system, could stimulate spermatogenesis and enhance sperm production in Senegalese sole F1 males...
2017: PloS One
https://www.readbyqxmd.com/read/28326509/the-steroid-response-to-human-chorionic-gonadotropin-hcg-stimulation-in-men-with-klinefelter-syndrome-does-not-change-using-immunoassay-or-mass-spectrometry
#3
L Roli, D Santi, S Belli, S Tagliavini, S Cavalieri, M C De Santis, E Baraldi, F Fanelli, M Mezzullo, A R Granata, U Pagotto, R Pasquali, V Rochira, C Carani, M Simoni, T Trenti
PURPOSE: Liquid-chromatography tandem mass-spectrometry (LC-MS/MS) was developed in parallel to Immunoassays (IAs) and today is proposed as the "gold standard" for steroid assays. Leydig cells of men with Klinefelter syndrome (KS) are able to respond to human chorionic gonadotropin (hCG) stimulation, even if testosterone (T) production was impaired. The aim was to evaluate how results obtained by IAs and LC-MS/MS can differently impact on the outcome of a clinical research on gonadal steroidogenesis after hCG stimulation...
March 21, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28317072/sonographic-classification-of-testicular-tumors-by-tissue-harmonic-imaging-experience-of-58-cases
#4
Atsuo Kawamoto, Tadashi Hatano, Kazuhiro Saito, Rie Inoue, Toshitaka Nagao, Shigeru Sanada
PURPOSE: To evaluate the relationship between our proposed sonographic classification of testicular tumors by tissue harmonic imaging and histological type. METHODS: We retrospectively analyzed 58 testicular tumors and tumor-like lesions [seminomatous germ cell tumor (SGCT): 28; non-seminomatous germ cell tumor (NSGCT): 16; lymphoid and hematopoietic tumor (LHT): 7; Leydig cell tumor: 1; epidermal cyst: 2; and tumor of paratesticular structure (TPS): 4]. We divided a sonographic image into six types for morphological criteria and three types for color Doppler criteria...
March 20, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28316852/retiform-sertoli-leydig-cell-tumor-in-a-38-year-old-woman-a-case-report-retrospective-review-and-review-of-current-literature
#5
Laura C Nwogu, Josh A Showalter, Suvra Roy, Michael T Deavers, Bihong Zhao
Ovarian sex cord-stromal tumors arise from the stromal cells that surround and support the oocytes. Sertoli-Leydig cell tumors belong to this category of ovarian neoplasms. We present the case of a 38-year-old woman who was found to have a right ovarian mass. The mass was resected and diagnosed as Stage I Sertoli-Leydig cell tumor, retiform variant, following histopathologic and immunohistochemical examination. This case is unusual given the rarity of the retiform variant of Sertoli-Leydig cell tumor and the atypically older age of 38 years at presentation...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28315012/chlorinated-biphenyls-effect-on-estrogen-related-receptor-expression-steroid-secretion-mitochondria-ultrastructure-but-not-on-mitochondrial-membrane-potential-in-leydig-cells
#6
Agnieszka Milon, Malgorzata Opydo-Chanek, Waclaw Tworzydlo, Jerzy Galas, Laura Pardyak, Alicja Kaminska, Anna Ptak, Malgorzata Kotula-Balak
To characterize polychlorinated biphenyls (PCBs) action on Leydig cells, PCBs congeners, low-chlorinated (delor 103; d103) and high-chlorinated ones (delor 106; d106) were selected. The cells were treated according to PCBs dose (d103 or d106 0.2 ng/ml in low doses:, or 2 ng/ml in high doses) and type (d103 + d106 in low doses or 103 + 106 in high doses). After 24 h treatment with PCBs, a distinct increase in estrogen-related receptors (ERRs type α, β and γ) expression was revealed. However, the dose- and type-dependent PCBs effect was mostly exerted on ERRα expression...
March 18, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28301534/the-spermatogenic-process-of-the-common-vampire-bat-desmodus-rotundus-under-a-histomorphometric-view
#7
Danielle Barbosa Morais, Luciano Carlos Heringer Porcaro Puga, Tarcízio Antônio Rêgo de Paula, Mariella Bontempo Duca Freitas, Sérgio Luis Pinto da Matta
Among all bat species, Desmodus rotundus stands out as one of the most intriguing due to its exclusively haematophagous feeding habits. However, little is known about their spermatogenic cycle. This study aimed at describing the spermatogenic process of common vampire bats through testicular histomorphometric characterization of adult specimens, spermatogenic production indexes, description of stages of the seminiferous epithelium cycle and estimative of the spermatogenic process duration. Morphometrical and immunohistochemical analyzes for bromodeoxiuridine were conducted under light microscopy and ultrastructural analyzes were performed under transmission electron microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28300557/high-fat-diet-aggravates-2-2-4-4-tetrabromodiphenyl-ether-inhibited-testosterone-production-via-dax-1-in-leydig-cells-in-rats
#8
Zhan Zhang, Yongquan Yu, Hengsen Xu, Chao Wang, Minghui Ji, Jun Gu, Lu Yang, Jiansheng Zhu, Huibin Dong, Shou-Lin Wang
Growing evidence has revealed that a high-fat diet (HFD) could lead to disorders of glycolipid metabolism and insulin-resistant states, and HFDs have been associated with the inhibition of testicular steroidogenesis. Our previous study demonstrated that 2,2',4,4'-tetrabromodiphenyl ether (BDE47) could increase the risk of diabetes in humans and reduce testosterone production in rats. However, whether the HFD affects BDE47-inhibited testosterone production by elevating insulin levels and inducing related pathways remains unknown...
March 12, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28296042/nickel-sulfate-induced-apoptosis-via-activating-ros-dependent-mitochondria-and-endoplasmic-reticulum-stress-pathways-in-rat-leydig-cells
#9
Lingyue Zou, Li Su, Yifan Sun, Aijie Han, Xuhong Chang, An Zhu, Fangfang Liu, Jin Li, Yingbiao Sun
Nickel can induce apoptosis of testicular Leydig cells in mice, whereas the mechanisms remain unclear. In this study, we investigated the role of nickel-induced reactive oxygen species (ROS) generation in mitochondria and endoplasmic reticulum stress (ERS) mediated apoptosis pathways in rat Leydig cells. Fluorescent DCF and Annexin-V FITC/PI staining were performed to measure the production of ROS and apoptosis in Leydig cells. RT-qPCR and Western blot were conducted to analyze the key genes and proteins involved in mitochondria and ERS apoptotic pathways...
March 15, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28295471/long-term-feeding-of-hydroalcoholic-extract-powder-of-lepidium-meyenii-maca-enhances-the-steroidogenic-ability-of-leydig-cells-to-alleviate-its-decline-with-ageing-in-male-rats
#10
K Yoshida, Y Ohta, N Kawate, M Takahashi, T Inaba, S Hatoya, H Morii, K Takahashi, M Ito, H Tamada
This study examined whether feeding hydroalcoholic extract of Lepidium meyenii (maca) to 8-week-old (sexually maturing) or 18-week-old (mature) male rats for more than a half year affects serum testosterone concentration and testosterone production by Leydig cells cultured with hCG, 22R-hydroxycholesterol or pregnenolone. Testosterone concentration was determined in the serum samples obtained before and 6, 12, 18 and 24 weeks after the feeding, and it was significantly increased only at the 6 weeks in the group fed with the maca extract to maturing rats when it was compared with controls...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28295462/ferulic-acid-prevents-lead-induced-testicular-oxidative-stress-and-suppressed-spermatogenesis-in-rats
#11
P Hasanein, F Fazeli, M Parviz, M Roghani
Lead affects multiple organ systems including testis. We investigated the effects of ferulic acid (FA) on lead-induced oxidative stress and spermatogenesis suppression in rats. Animals received lead acetate (500 mg/L in drinking water) and/or FA (50 mg/kg, i.g.) for eight weeks. Lead increased testicular malondialdehyde (MDA) and nitrite levels and decreased glutathione (GSH) content and catalase (CAT) activity. Lead decreased testis weight and testosterone level. Sperm parameters decreased in lead group...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28286655/metabolic-endotoxaemia-related-inflammation-is-associated-with-hypogonadism-in-overweight-men
#12
Kelton Tremellen, Natalie McPhee, Karma Pearce
BACKGROUND: Obesity is associated with both impaired testosterone production and a chronic state of low grade inflammation. Previously it was believed that this inflammation was mediated by a decline in the immunosuppressive action of testosterone. However, more recently an alternative hypothesis (GELDING theory) has suggested that inflammation originating from the passage of intestinal bacteria into the circulation (metabolic endotoxaemia) may actually be the cause of impaired testicular function in obese men...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28281692/ibuprofen-results-in-alterations-of-human-fetal-testis-development
#13
Millissia Ben Maamar, Laurianne Lesné, Kristin Hennig, Christèle Desdoits-Lethimonier, Karen R Kilcoyne, Isabelle Coiffec, Antoine D Rolland, Cécile Chevrier, David M Kristensen, Vincent Lavoué, Jean-Philippe Antignac, Bruno Le Bizec, Nathalie Dejucq-Rainsford, Rod T Mitchell, Séverine Mazaud-Guittot, Bernard Jégou
Among pregnant women ibuprofen is one of the most frequently used pharmaceutical compounds with up to 28% reporting use. Regardless of this, it remains unknown whether ibuprofen could act as an endocrine disruptor as reported for fellow analgesics paracetamol and aspirin. To investigate this, we exposed human fetal testes (7-17 gestational weeks (GW)) to ibuprofen using ex vivo culture and xenograft systems. Ibuprofen suppressed testosterone and Leydig cell hormone INSL3 during culture of 8-9 GW fetal testes with concomitant reduction in expression of the steroidogenic enzymes CYP11A1, CYP17A1 and HSD17B3, and of INSL3...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28277341/analgesic-use-in-pregnancy-and-male-reproductive-development
#14
Pablo Hurtado-Gonzalez, Rod T Mitchell
PURPOSE OF REVIEW: Male reproductive disorders are common and increasing in incidence in many countries. Environmental factors (including pharmaceuticals) have been implicated in the development of these disorders. This review aims to summarize the emerging epidemiological and experimental evidence for a potential role of in-utero exposure to analgesics in the development of male reproductive disorders. RECENT FINDINGS: A number of epidemiological studies have demonstrated an association between in utero exposure to analgesics and the development of cryptorchidism, although these findings are not consistent across all studies...
March 8, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28274746/transcription-factors-sf1-and-cjun-cooperate-to-activate-the-fdx1-promoter-in-ma-10-leydig-cells
#15
Pauline Roumaud, Arlette Rwigemera, Luc J Martin
The Ferredoxin 1 (FDX1) protein supports steroid biosynthesis in steroidogenic cells through electron transfer to the rate-limiting steroidogenic enzyme, CYP11A1. The latter catalyzes the conversion of cholesterol to pregnenolone through side chain cleavage inside the mitochondria. Thus far, only several transcription factors have been implicated in the regulation of mouse Fdx1 promoter activity in Leydig cells. These include the nuclear receptor SF1 and SP1. Since two conserved regulatory elements for AP1 transcription factors have been located at -764 and -617bp of the Fdx1 promoter, we hypothesized that cJUN may cooperate with other partners to regulate Fdx1 in Leydig cells...
March 6, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28267506/inhibition-of-acrolein-induced-autophagy-and-apoptosis-by-a-glycosaminoglycan-from-sepia-esculenta-ink-in-mouse-leydig-cells
#16
Yi-Peng Gu, Xiao-Mei Yang, Ping Luo, Yan-Qun Li, Ye-Xing Tao, Zhen-Hua Duan, Wei Xiao, Da-Yan Zhang, Hua-Zhong Liu
In our recent reports, a squid ink polysaccharide (SIP) was found having preventive activity against cyclophosphamide induced damage in mouse testis and ovary. Here we further reveal the regulative mechanism of SIP against chemical toxicity on testis. Leydig cells exposed to acrolein (ACR) underwent apoptosis at 12h and 24h. Before apoptosis, cells occurred autophagy that was confirmed by high autophagic rate and Beclin-1 protein content at 3h. PI3K/Akt and p38 MAPK signal pathways involved in the regulatory mechanisms...
May 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28266530/esr1-inhibits-hcg-induced-steroidogenesis-and-proliferation-of-progenitor-leydig-cells-in-mice
#17
Yeong Seok Oh, Il Kyoo Koh, Bomi Choi, Myung Chan Gye
Oestrogen is an important regulator in reproduction. To understand the role of oestrogen receptor 1 (ESR1) in Leydig cells, we investigated the expression of ESR1 in mouse Leydig cells during postnatal development and the effects of oestrogen on steroidogenesis and proliferation of progenitor Leydig cells (PLCs). In Leydig cells, the ESR1 expression was low at birth, increased until postnatal day 14 at which PLCs were predominant, and then decreased until adulthood. In foetal Leydig cells, ESR1 immunoreactivity increased from birth to postnatal day 14...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28262687/the-syndrome-of-central-hypothyroidism-and-macroorchidism-igsf1-controls-trhr-and-fshb-expression-by-differential-modulation-of-pituitary-tgf%C3%AE-and-activin-pathways
#18
Marta García, Raquel Barrio, Montserrat García-Lavandeira, Angela R Garcia-Rendueles, Adela Escudero, Esther Díaz-Rodríguez, Darya Gorbenko Del Blanco, Ana Fernández, Yolanda B de Rijke, Elena Vallespín, Julián Nevado, Pablo Lapunzina, Vilborg Matre, Patricia M Hinkle, Anita C S Hokken-Koelega, María P de Miguel, José Manuel Cameselle-Teijeiro, Manuel Nistal, Clara V Alvarez, José C Moreno
IGSF1 (Immunoglobulin Superfamily 1) gene defects cause central hypothyroidism and macroorchidism. However, the pathogenic mechanisms of the disease remain unclear. Based on a patient with a full deletion of IGSF1 clinically followed from neonate to adulthood, we investigated a common pituitary origin for hypothyroidism and macroorchidism, and the role of IGSF1 as regulator of pituitary hormone secretion. The patient showed congenital central hypothyroidism with reduced TSH biopotency, over-secretion of FSH at neonatal minipuberty and macroorchidism from 3 years of age...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28261840/feeding-hydroalcoholic-extract-powder-of-lepidium-meyenii-maca-enhances-testicular-gene-expression-of-3%C3%AE-hydroxysteroid-dehydrogenase-in-rats
#19
Y Ohta, N Kawate, T Inaba, H Morii, K Takahashi, H Tamada
Although feeding diets containing the extract powder of Lepidium meyenii (maca), a plant growing in Peru's Central Andes, increases serum testosterone concentration associated with enhanced ability of testosterone production by Leydig cells in male rats, changes in testicular steroidogenesis-related factors by the maca treatment are not known. This study examined the effects of maca on testicular gene expressions for luteinizing hormone receptor, steroidogenic acute regulatory protein and steroidogenic enzymes...
March 6, 2017: Andrologia
https://www.readbyqxmd.com/read/28261663/zika-virus-causes-testicular-atrophy
#20
Ryuta Uraki, Jesse Hwang, Kellie Ann Jurado, Sarah Householder, Laura J Yockey, Andrew K Hastings, Robert J Homer, Akiko Iwasaki, Erol Fikrig
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that has recently been found to cause fetal infection and neonatal abnormalities, including microcephaly and neurological dysfunction. ZIKV persists in the semen months after the acute viremic phase in humans. To further understand the consequences of ZIKV persistence in males, we infected Ifnar1(-/-) mice via subcutaneous injection of a pathogenic but nonlethal ZIKV strain. ZIKV replication persists within the testes even after clearance from the blood, with interstitial, testosterone-producing Leydig cells supporting virus replication...
February 2017: Science Advances
keyword
keyword
28874
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"