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https://www.readbyqxmd.com/read/28812227/effects-of-fluoride-on-surface-structure-of-primary-culture-leydig-cells-in-mouse
#1
Jian Li, Yan Shi, Hua Fan, Yanyan Li, Yuchen Zhu, Xijun Lin, Jianhai Zhang
Fluoride (F) is known to induce reproduction toxicity, and the elucidation of its underlying mechanisms is an ongoing research. These findings aim to provide deeper insights into roles of soduim fluoride (NaF) in testis damage, which could contribute to a better understanding of fluoride-induced male reproductive toxicity. The Leydig cells were administrated by 0, 5, 10, and 20 mg/L NaF for 24 h, respectively. Scanning electron microscope was used to identify the change of surface structure in the Leydig cells...
August 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28794165/steroidogenesis-during-postnatal-testicular-development-of-galea-spixii
#2
Paulo Ramos da Silva Santos, Francilieusa Delys Oliveira, Maria Angélica Machado Arroyo, Moacir Franco Oliveira, Patricia Castelucci, Alan Conley, Antônio Chaves de Assis Neto
The androgen/estrogen balance is essential for normal sexual development and reproduction in mammals. Studies performed herein investigated the potential for estrogen synthesis in cells of the testes of a hystricomorph rodent, Galea spixii. The study characterized the expression of the key enzymes responsible for estrogen and androgen synthesis, cytochromes P450 aromatase (P450arom), 17α-hydroxylase/17,20-lyase (P450c17) respectively, as well as the redox partner NADPH cytochrome P450 oxido-reductase (CPR) required to support electron transfer and catalysis of these P450s, by immunohistochemistry (IHC) and quantitative polymerase chain reaction (qPCR) analysis, throughout postnatal sexual development...
August 8, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28792252/rosa-damascena-mill-essential-oil-has-protective-effect-against-testicular-damage-in-diabetic-rats
#3
Somayeh Hamedi, Tahoora Shomali, Aliakbar Haghighat
This study investigates the protective effect of Rosa damascena essential oil on diabetes-induced testicular damage in rats. Thirty-six male Wistar rats were randomly divided into 6 equal groups: Group I: negative control (no treatment); Group II: positive control (diabetic by alloxan injection); Groups III-VI that rendered diabetic and received, respectively, 50, 100, 200, and 400 µg/kg/day rose oil, orally for 28 days. Rose oil did not significantly change body weight and blood glucose level as compared to positive control...
August 9, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28791335/internalization-of-rat-fsh-and-lh-cg-receptors-by-rec-ecg-in-cho-k1-cells
#4
Jong-Ju Park, Hun-Ki Seong, Jeong-Soo Kim, Byambaragchaa Munkhzaya, Myung-Hwa Kang, Kwan-Sik Min
Equine chorionic gonadotropin (eCG) is a unique molecule that elicits the response characteristics of both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in other species. Previous studies from this laboratory had demonstrated that recombinant eCG (rec-eCG) from Chinese hamster ovary (CHO-K1) cells exhibited both FSH- and LH-like activity in rat granulosa and Leydig cells. In this study, we analyzed receptor internalization through rec-eCGs, wild type eCG (eCGβ/α) and mutant eCG (eCGβ/αΔ56) with an N-linked oligosaccharide at Asn(56) of the α-subunit...
June 2017: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/28782242/effects-of-hyper-and-hypothyroidism-on-the-development-and-proliferation-of-testicular-cells-in-prepubertal-rats
#5
Mohamed Babo Fadlalla, Quanwei Wei, Jaafar Sulieman Fedail, Asif Mehfooz, Dagan Mao, Fangxiong Shi
Thyroid hormones are important in the development and regulation of testes. This study was conducted to determine the effects of hyper- and hypothyroidism on testicular development in prepubertal rats aged 20-70 days. Weaning male rats (20 days old) until day 70 age were randomly divided into four groups: control, hyperthyroid (hyper-T), hypothyroid (hypo-T) and hypothyroid treated with thyroxine (T4) (hypo-T+T4). The results indicated that thyroid hormones caused a significant effect in body and testis weights, and food and water consumption...
August 7, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28780938/corrigendum-to-leydig-cell-stem-cells-identification-proliferation-and-differentiation-mol-cell-endocrinol-xxx-2016-1-9
#6
Haolin Chen, Yiyan Wang, Renshan Ge, Barry R Zirkin
No abstract text is available yet for this article.
October 15, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28780937/corrigendum-to-transplantation-of-alginate-encapsulated-seminiferous-tubules-and-interstitial-tissue-into-adult-rats-leydig-stem-cell-differentiation-in%C3%A2-vivo-mol-cell-endocrinol-436-2016-250-258
#7
Haolin Chen, Shiying Jin, Shengsong Huang, Janet Folmer, June Liu, Renshan Ge, Barry R Zirkin
No abstract text is available yet for this article.
October 15, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28774687/the-environment-and-male-reproduction-the-effect-of-cadmium-exposure-on-reproductive-system-and-semen-quality-and-its-implication-in-fertility
#8
REVIEW
Cristina de Angelis, Mariano Galdiero, Claudia Pivonello, Ciro Salzano, Daniele Gianfrilli, Prisco Piscitelli, Andrea Lenzi, Annamaria Colao, Rosario Pivonello
Cadmium is an environmental pollutant known as endocrine disruptor. Testis is particularly susceptible to cadmium, and testis injury occurs at high but even low levels of exposure. Cadmium reproductive toxicity is mediated by multiple mechanisms, including structural damage to testis vasculature and blood-testis barrier, inflammation, cytotoxicity on Sertoli and Leydig cells, oxidative stress, apoptosis, epigenetic actions, and disturbance of the hypothalamus-pituitary-gonadal axis. The current review outlines epidemiological observational findings from environmental and occupational exposure in humans, and reports experimental studies in humans and animals...
July 31, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28772110/leydig-cell-dysfunction-systemic-inflammation-and-metabolic-syndrome-in-long-term-testicular-cancer-survivors
#9
M Bandak, N Jørgensen, A Juul, J Lauritsen, P S Oturai, J Mortensen, P Hojman, J W Helge, G Daugaard
BACKGROUND: Twenty to thirty percent of testicular cancer (TC) survivors have elevated serum levels of luteinising hormone (LH) with or without corresponding low testosterone levels (Leydig cell dysfunction) during clinical follow-up for TC. However, it remains to be clarified if this subgroup of TC survivors has an increased long-term risk of systemic inflammation and metabolic syndrome (MetS) when compared with TC survivors with normal Leydig cell function during follow-up. PATIENTS AND METHODS: TC survivors with Leydig cell dysfunction and a control group of TC survivors with normal Leydig cell function during follow-up were eligible for participation in the study...
July 31, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28771045/expression-patterns-and-changes-of-the-lcn2-gene-in-the-testes-of-induced-cryptorchidism-and-busulfan-treated-mice
#10
Zhenlong Kang, Na Qiao, Zhigang Tan, Zhaoxin Tang, Ying Li
Lipocalin-2 (LCN2) was known to play various roles in different type cells; however, little was known about the effect of LCN2 in male fertility. In this study, we aimed to explore the expression pattern of LCN2 with increasing age in mice, and to obtain insight into the role of LCN2 in mice testes by induced cryptorchidism and busulfan-treated infertility. In situ hybridization showed that LCN2 was localized primarily in Leydig cells, but was absent in Sertoli and germ cells. Its expression in testes exhibited an age-related increase from day 1 to 8 months, then reduced by the twelth month...
August 3, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28770898/sex-cord-stromal-tumours-of-the-ovary-experience-at-shifa-international-hospital-islamabad
#11
Asim Qureshi, Masroor Hassan, Nadira Mamoon, Zafar Ali, Imran Nazir Ahmed
This descriptive study was carried out at Pathology Department, Shifa International Hospital from 2007 to 2016; all sex cord stromal tumours diagnosed during this time period were included. Epithelial, germ cell and metastatic tumours were excluded from the study. A total of 1254 Ovarian tumours were brought to Shifa of which47 (4%) were labeled as sex cord stromal tumours. Of these 36( 76 %)were granulosa cell tumour (adult33, juvenile3), 7 were labeled as sertoli leydig cell tumours (15%), 3 as thecoma/ fibroma group (7%)and only one case was labeled as microcystic stromal tumour of the ovary (2%)...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28770110/do-insulin-replacement-and-omega3-protect-the-male-reproductive-function-of-the-streptozotocin-induced-diabetic-mice
#12
Atefe Yaghoubi, Abbas Shahedi, Hakime Akbari, Seyed Noureddin Nematollahi-Mahani
Diabetes mellitus (DM), the most common metabolic disease, might affect different organs such as male reproductive system. Experiments have shown that n-3 fatty acids could improve male reproductive function. Present study was performed to examine the effects of omega3 on sperms and testicular parameters in diabetic mice. Adult NMRI male mice were randomly divided into intact and diabetic groups (n = 8). Streptozotocin-induced diabetic animals were divided into 4 groups of diabetic-saline (Dia-Sa), diabetic-insulin (Dia-Ins), diabetic-omega3 (Dia-omg3), and diabetic-insulin-omega3 (Dia-Ins-omg3)...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28765489/embryonal-carcinoma-presenting-as-a-calcified-solitary-testicular-mass-on-ultrasound
#13
Daniel Gerber, Henry Collier Wright, Rachael D Sussman, Lambros Stamatakis
A 24-year-old man presented with a 2-week history of a painless right testicular mass; ultrasound demonstrated a dense, solitary calcified mass. The patient elected observation after further workup showed no evidence of metastasis.A repeat ultrasound 3 months later showed interval growth and the patient underwent right radical orchiectomy. Pathology was consistent with pure embryonal carcinoma of the testis. Calcified testicular masses are typically benign but do carry a differential of spermatic granuloma, large-cell calcifying Sertoli cell tumour, trauma, tuberculosis, filariasis, calcified Leydig cell tumour and burned-out testicular tumour...
July 31, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28765008/microcystin-leucine-arginine-exhibits-immunomodulatory-roles-in-testicular-cells-resulting-in-orchitis
#14
Yabing Chen, Jing Wang, Qin Zhang, Zou Xiang, Dongmei Li, Xiaodong Han
Microcystin-leucine arginine (MC-LR) causes testicular inflammation and hinders spermatogenesis. However, the molecular mechanisms underlying the immune responses to MC-LR in the testis have not been elucidated in detail. In this study, we show that MC-LR induced immune responses in Sertoli cells (SC), germ cells (GC), and Leydig cells (LC) via activating phosphatidylinositol 3-kinase (PI3K)/AKT/nuclear factor kappa B (NF-κB), resulting in the production of pro-inflammatory cytokines and chemokines including tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and chemokine (C-X-C motif) ligand 10 (CXCL10)...
July 29, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28762514/differential-expression-of-micrornas-in-luteinising-hormone-treated-mouse-tm3-leydig-cells
#15
C Li, S Gao, S Chen, L Chen, Y Zhao, Y Jiang, X Zheng, X Zhou
Testosterone is primarily produced by Leydig cells of the mammalian male gonads. The cellular functions of Leydig cells are regulated by the hypothalamus-pituitary-gonad axis, whereas the microRNA (miRNA) changes of LH-treated Leydig cells are unknown. Mouse TM3 Leydig cells were treated with LH, and deep sequencing showed that 29 miRNAs were significantly different between two groups (fold change of >1.5 or <0.5, p < .05), of which 27 were upregulated and two were downregulated. The differential expression of miR-29b-3p, miR-378b, miR-193b and miR-3695 was confirmed by quantitative real-time polymerase chain reaction...
August 1, 2017: Andrologia
https://www.readbyqxmd.com/read/28756368/cadmium-chloride-induced-testicular-toxicity-in-male-wistar-rats-prophylactic-effect-of-quercetin-and-assessment-of-testicular-recovery-following-cadmium-chloride-withdrawal
#16
Victor U Nna, Godwin A Ujah, Mahaneem Mohamed, Kingsley B Etim, Benedict O Igba, Ele R Augustine, Eme E Osim
This study assessed the effect of quercetin (QE) on cadmium chloride (CdCl2) - induced testicular toxicity, as well as the effect of withdrawal of CdCl2 treatment on same. Thirty male Wistar rats aged 10 weeks old and weighing 270-300g were assigned into 5 groups and used for this study. Rats in groups 1-4 were administered vehicle, CdCl2 (5mg/kg bwt), CdCl2+QE (5mg/kg bwt and 20mg/kg bwt, respectively) or QE (20mg/kg bwt) orally for 4 weeks. Group 5 rats received CdCl2, with 4 weeks recovery period. Results showed that cadmium accumulated in serum, testis and epididymis, decreased body weight, testicular and epididymal weights, sperm count, motility and viability...
July 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28753832/longitudinal-changes-in-serum-levels-of-testosterone-and-luteinizing-hormone-in-testicular-cancer-patients-after-orchiectomy-alone-or-bleomycin-etoposide-and-cisplatin
#17
Mikkel Bandak, Niels Jørgensen, Anders Juul, Jakob Lauritsen, Maria Gry Gundgaard Kier, Mette Saksø Mortensen, Gedske Daugaard
BACKGROUND: Controversy exists whether Leydig cells recover after testicular cancer (TC) treatment or whether premature hormonal aging will occur. OBJECTIVE: Evaluate serial changes in total testosterone (TT) and luteinizing hormone (LH) in patients treated with orchiectomy alone (Stage I) or combination chemotherapy with bleomycin, etoposide, and cisplatin (BEP). DESIGN, SETTINGS, AND PARTICIPANTS: Changes in TT and LH were investigated during 5-yr follow-up (Stage I: n=75, BEP: n=81)...
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28752067/two-stage-urethroplasty-with-buccal-mucosa-for-penoscrotal-hypospadias-reconstruction-in-a-male-with-a-46-xx-karyotype
#18
Pieter D'hulst, Jochen Darras, Steven Joniau, Pieter Mattelaer, Linsey Winne, Diederik Ponette
We present a case regarding a 32-year old African male with penoscrotal hypospadias, left cryptorchidism and a left inguinal hernia. There were moderate masculinization characteristics. He underwent a Lichtenstein hernia repair with perioperative biopsies of the left inguinal testis and epididymis. Microscopic examination showed a Sertoli-only left testis with Leydig-cell hyperplasia and the left epididymis consisted of ovarian tissue with corpora albicantia and maturing follicles. Endocrinological evaluation showed a sex-determining region Y (SRY) negative 46,XX karyotype...
September 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28751916/sertoli-leydig-cell-tumor-with-concurrent-rhabdomyosarcoma-three-case-reports-and-a-review-of-the-literature
#19
Trisha Plastini, Arthur Staddon
Sertoli-Leydig Cell Tumors (SLCTs) make up <1% of all ovarian tumors and are benign or malignant, androgen-secreting tumors. Rhabdomyosarcoma (RMS) is a heterogeneous group of malignant tumors that resemble developing skeletal muscle. There have been case reports of patients with concurrent SLCT and RMS with limited treatment options. We aim to demonstrate treatment strategies used in our patients, which seemed to have prolonged survival when compared to prior case reports of patients not cured by surgical resection...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28750644/a-retrospective-study-of-reproductive-outcomes-after-fertility-sparing-surgery-and-postoperative-adjuvant-chemotherapy-in-malignant-ovarian-germ-cell-tumors-and-sex-cord-stromal-tumors
#20
Ning Zhang, Ruifang Chen, Keqin Hua, Ying Zhang
BACKGROUND: To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST). METHODS: Data from 32 MOGCT (6 dysgerminomas, 6 yolk sac tumors, 17 immature teratomas, and 3 mixed germ cell tumors) and 9 SCST (4 granulosa cell tumors and 5 sertoli-leydig cell tumors) aged from 18 to 35, treated in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were collected and analyzed...
July 27, 2017: Journal of Ovarian Research
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