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https://www.readbyqxmd.com/read/28547881/prevalence-and-clinical-correlates-of-insomnia-in-adults-with-attention-deficit-hyperactivity-disorder
#1
E J Brevik, A J Lundervold, A Halmøy, M-B Posserud, J T Instanes, B Bjorvatn, J Haavik
OBJECTIVE: To investigate the prevalence of insomnia in adults with Attention-deficit hyperactivity disorder (ADHD) and its association with clinical subtypes, current ADHD symptoms, and stimulant treatment. METHOD: We obtained diagnostic information, symptom rating scales and treatment history from clinically ascertained adult ADHD patients diagnosed according to DSM-IV criteria (n = 268, mean age 38.1 years) and randomly selected population controls (n = 202, mean age 36...
May 26, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28546869/smoking-alcohol-and-drug-use-in-youth-and-adults-with-attention-deficit-hyperactivity-disorder
#2
Sydney Osland, Lauren Hirsch, Tamara Pringsheim
BACKGROUND: Previous research suggests a relationship between attention-deficit hyperactivity disorder (ADHD) and smoking, alcohol and illicit drug use, however most studies have focused on adolescents or young adults, or clinically ascertained samples. AIMS: To analyse population-based data on the relationship between ADHD and at-risk health behaviours in adolescents and adults. METHOD: Data were derived from a Statistics Canada population-based health survey...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28544581/a-comparison-of-the-pharmacokinetics-of-methylphenidate-extended-release-orally-disintegrating-tablets-with-a-reference-extended-release-formulation-of-methylphenidate-in-healthy-adults
#3
Ann Childress, Jeffrey G Stark, Russ McMahen, Dorothy Engelking, Carolyn Sikes
Extended-release (ER) methylphenidate (MPH) is a first-line treatment for attention-deficit/hyperactivity disorder. A methylphenidate extended-release orally disintegrating tablet (MPH XR-ODT) has recently been developed. This was a randomized, open-label, 3-period, 3-treatment study comparing the bioavailability and absorption of 2 MPH XR-ODT formulations with an MPH ER reference medication. Here we report the 2 treatments comparing the commercial MPH XR-ODT formulation and reference medication. Following a ≥10-hour fast, 42 healthy adults received 60 mg of reference medication or MPH XR-ODT (2 × 30 mg)...
May 25, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28544344/fed-and-fasted-administration-of-a-novel-extended-release-methylphenidate-orally-disintegrating-tablet-formulation-for-the-treatment-of-adhd
#4
Richard H Weisler, Jeffrey G Stark, Carolyn Sikes
Extended-release methylphenidate is a first-line treatment for attention-deficit/hyperactivity disorder. A methylphenidate extended-release orally disintegrating tablet (MPH XR-ODT) has recently been developed. Here we report an open-label, randomized, 2-period, 2-treatment crossover study to determine the effect of food on the bioavailability of a single 60-mg dose of MPH XR-ODT in healthy adults. Blood samples were collected predose through 36 hours postdose. Maximum plasma concentration (Cmax ), time to maximum plasma concentration (Tmax ), terminal elimination half-life (T1/2 ), overall systemic exposure (AUClast and AUCinf ), and partial areas under the concentration curve (AUC0-3 , AUC3-7 , and AUC7-12 ) were calculated...
May 25, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28542383/performance-in-eyeblink-conditioning-is-age-and-sex-dependent
#5
Karolina Löwgren, Rasmus Bååth, Anders Rasmussen, Henk-Jan Boele, Sebastiaan K E Koekkoek, Chris I De Zeeuw, Germund Hesslow
A growing body of evidence suggests that the cerebellum is involved in both cognition and language. Abnormal cerebellar development may contribute to neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD), autism, fetal alcohol syndrome, dyslexia, and specific language impairment. Performance in eyeblink conditioning, which depends on the cerebellum, can potentially be used to clarify the neural mechanisms underlying the cerebellar dysfunction in disorders like these. However, we must first understand how the performance develops in children who do not have a disorder...
2017: PloS One
https://www.readbyqxmd.com/read/28542365/delusion-proneness-displays-comorbidity-with-traits-of-autistic-spectrum-disorders-and-adhd
#6
Anaïs Louzolo, Petter Gustavsson, Lars Tigerström, Martin Ingvar, Andreas Olsson, Predrag Petrovic
There is an increasing body of evidence suggesting a significant comorbidity between psychotic disorders such as schizophrenia and attention-deficit/hyperactivity disorder (ADHD) or autism-spectrum disorders (ASD). Recently, research on psychosis-proneness in otherwise healthy individuals has been a promising way to better understand the mechanisms underlying psychosis. As both ADHD and ASD symptoms show a normal distribution in the general population, such trait comorbidity may confound studies on psychosis-proneness...
2017: PloS One
https://www.readbyqxmd.com/read/28536846/time-on-task-effects-in-children-with-and-without-adhd-depletion-of-executive-resources-or-depletion-of-motivation
#7
Tycho J Dekkers, Joost A Agelink van Rentergem, Alette Koole, Wery P M van den Wildenberg, Arne Popma, Anika Bexkens, Reino Stoffelsen, Anouk Diekmann, Hilde M Huizenga
Children with attention-deficit/hyperactivity disorder (ADHD) are characterized by deficits in their executive functioning and motivation. In addition, these children are characterized by a decline in performance as time-on-task increases (i.e., time-on-task effects). However, it is unknown whether these time-on-task effects should be attributed to deficits in executive functioning or to deficits in motivation. Some studies in typically developing (TD) adults indicated that time-on-task effects should be interpreted as depletion of executive resources, but other studies suggested that they represent depletion of motivation...
May 23, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28529361/prevalence-and-correlates-of-obsessive-compulsive-disorder-and-subthreshold-obsessive-compulsive-disorder-among-college-students-in-kerala-india
#8
T S Jaisoorya, Y C Janardhan Reddy, B Sivasankaran Nair, Anjana Rani, Priya G Menon, M Revamma, C R Jeevan, K S Radhakrishnan, Vineetha Jose, K Thennarasu
CONTEXT: There are scarce data on the prevalence of adult obsessive-compulsive disorder (OCD) in India. AIMS: The aim was to study the point prevalence of OCD and subthreshold OCD and its psychosocial correlates among college students in the district of Ernakulam, Kerala, India. SETTINGS AND DESIGN: A cross-sectional survey of 5784 students of the age range of 18-25 years from 58 colleges was conducted. MATERIALS AND METHODS: Students were self-administered the OCD subsection of the Clinical Interview Schedule-Revised, the Composite International Diagnostic Interview for obsessive-compulsive symptoms (OCSs), and other relevant instruments to identify OCD, subthreshold OCD, and related clinical measures...
January 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28520552/prestimulus-inhibition-of-saccades-in-adults-with-and-without-attention-deficit-hyperactivity-disorder-as-an-index-of-temporal-expectations
#9
Yarden Dankner, Lilach Shalev, Marisa Carrasco, Shlomit Yuval-Greenberg
Knowing when to expect important events to occur is critical for preparing context-appropriate behavior. However, anticipation is inherently complicated to assess because conventional measurements of behavior, such as accuracy and reaction time, are available only after the predicted event has occurred. Anticipatory processes, which occur prior to target onset, are typically measured only retrospectively by these methods. In this study, we utilized a novel approach for assessing temporal expectations through the dynamics of prestimulus saccades...
May 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28512748/genetic-influences-on-adhd-symptom-dimensions-examination-of-a-priori-candidates-gene-based-tests-genome-wide-variation-and-snp-heritability
#10
L Cinnamon Bidwell, Joshua C Gray, Jessica Weafer, Abraham A Palmer, Harriet de Wit, James MacKillop
Although the heritability of ADHD is estimated to be high, identifying specific genetic markers remains challenging. Most studies to date have examined the genetic basis of ADHD by employing dichotomous diagnostic phenotypes, but, as ADHD symptoms tend to be phenotypically dimensional, an alternative and potentially informative approach is to examine continuous indices of inattention and hyperactivity-impulsivity symptoms. The current study aimed to identify genetic effects on dimensionally-focused adult ADHD-related phenotypes in 990 individuals of European ancestry with intentionally low levels of substance misuse to avoid confounding...
June 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28508302/handedness-and-attention-deficit-hyperactivity-disorder-symptoms-in-college-students
#11
Hui-Li Lin, Hui-Chun Tsuang
The symptoms of adult Attention Deficit/Hyperactivity Disorder (ADHD) generally include impaired concentration; an insensitivity to social cues, being hard to get along with, and being internally restlessness. It is not surprising that these problems are likely to affect the performance of college students with ADHD. The study aims to examine whether ADHD symptoms are associated with handedness in college students in Taiwan. A total of 505 male and 645 female participants completed Annett's handedness questionnaire and the Traditional Chinese College ADHD Response Evaluation Student Response Inventory (C-CARE-SRI)...
May 16, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28504540/meta-analysis-of-cognitive-behavioral-treatments-for-adult-adhd
#12
Laura E Knouse, Jonathan Teller, Milan A Brooks
OBJECTIVE: We conducted a meta-analysis of cognitive-behavioral treatment (CBT) studies for adult attention-deficit/hyperactivity disorder (ADHD), examining effects versus control and effects pre-to-post treatment to maximize the clinical and research utility of findings from this growing literature. METHOD: Eligible studies tested adults meeting criteria for Diagnostic and Statistical Manual of Mental Disorders ADHD as determined by interview or using a standardized rating scale and measured ADHD symptoms or related impairment at baseline and posttreatment...
May 15, 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28501733/insomnia-in-adult-attention-deficit-hyperactivity-disorder-a-comparison-with-borderline-personality-disorder-population-in-a-clinical-setting-and-control-participants
#13
Sébastien Weibel, Françoise Jermann, Luisa Weiner, Rosetta Nicastro, Stefano Ardu, Eleonore Pham, Roland Hasler, Alexandre Dayer, Paco Prada, Nader Perroud
OBJECTIVES: Many adults with attention-deficit/hyperactivity disorder (ADHD) report sleeping difficulties. The relationship between sleep and ADHD is poorly understood, and shows discrepancies between subjective and objective measures. In order to determine the specificity of sleep-associated symptoms in ADHD, subjective sleep assessments among ADHD adult patients were compared with control subjects and with individuals suffering from borderline personality disorder (BPD). METHODS: 129 outpatients with ADHD, 70 with BPD (including 17 patients with BPD and ADHD comorbidity), and 65 control participants were assessed for sleep quality, insomnia, and sleepiness, using the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), and the Epworth Sleepiness Scale (ESS)...
May 5, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28498045/problematic-video-game-play-and-adhd-traits-in-an-adult-population
#14
Maria Panagiotidi
This study examined the relationship between problematic video game play (PVGP), video game usage, and attention deficit hyperactivity disorder (ADHD) traits in an adult population. A sample of 205 healthy adult volunteers completed the Adult ADHD Self-Report Scale (ASRS), a video game usage questionnaire, and the Problem Video Game Playing Test (PVGT). A significant positive correlation was found between the ASRS and the PVGT. More specifically, inattention symptoms and time spent playing video games were the best predictors of PVGP...
May 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28497641/adult-executive-functioning-inventory-adexi-validity-reliability-and-relations-to-adhd
#15
Ylva Holst, Lisa B Thorell
This study examined the psychometric properties of the Adult Executive Functioning Inventory (ADEXI). This new executive functioning (EF) rating instrument has the advantage of being brief (14 items) and focusing specifically on working memory and inhibitory control. Results showed that scores on the ADEXI had high internal consistency and adequate test-retest reliability, but low concurrence between self-ratings and other ratings. High and statistically significant correlations were found between ADEXI scores and scores from another EF rating instrument, whereas the correlations between ADEXI scores and neuropsychological test scores were weak and often non-significant...
May 12, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28494748/the-novelty-of-bupropion-as-a-dopaminergic-antidepressant-for-the-treatment-of-adult-attention-deficit-hyperactive-disorder
#16
Kanit Tha Deang, Hatta Sidi, Hazli Zakaria, Raja Lope Adam, Srijit Das, Nurul Hazwani Hatta, Muhammad Hatta, Kok Wei Wee
Attention deficit hyperactive disorder (ADHD), a hyperactivity disorder that is prevalent among children may continue as an adulthood attention deficit. To date, treating an individual with an adult ADHD may be an arduous task as it involved numerous challenges, such as a need for high index of suspicion to diagnose this medical condition. Many psychiatric disorders masquerade as ADHD and delayed the necessary assessment and proper treatment for the debilitating medical condition. Adult ADHD would also be misdiagnosed (or under diagnosed) due to the facts that this medical condition is being masked by his or her high level of intellectuality achievement...
May 11, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28490222/inattention-and-hyperactivity-impulsivity-their-detrimental-effect-on-romantic-relationship-maintenance
#17
Laura E VanderDrift, Kevin M Antshel, Amy K Olszewski
OBJECTIVE: The aim of this study is to understand how ADHD symptoms correlate with romantic relationship maintenance and test theoretical pathways by which symptoms of ADHD lead to relationship difficulties. METHOD: This study involved two phases of data collection, which were identical except for the population. Phase 1 ( n = 172) was a nonclinical sample of romantically involved young adults. Phase 2 ( n = 39) was a clinical sample of romantically involved young adults with ADHD...
May 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28488369/transitioning-from-child-and-adolescent-mental-health-services-with-attention-deficit-hyperactivity-disorder-in-ireland-case-note-review
#18
Mimi Tatlow-Golden, Blanaid Gavin, Niamh McNamara, Swaran Singh, Tamsin Ford, Moli Paul, Walter Cullen, Fiona McNicholas
In a context of international concern about early adult mental health service provision, this study identifies characteristics and service outcomes of young people with attention-deficit hyperactivity disorder (ADHD) reaching the child and adolescent mental health service (CAMHS) transition boundary (TB) in Ireland. The iTRACK study invited all 60 CAMHS teams in Ireland to participate; 8 teams retrospectively identified clinical case files for 62 eligible young people reaching the CAMHS TB in all 4 Health Service Executive Regions...
May 10, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28485014/evaluation-of-algorithms-to-identify-delirium-in-administrative-claims-and-drug-utilization-database
#19
Dae Hyun Kim, Jung Lee, Caroline A Kim, Krista F Huybrechts, Brian T Bateman, Elisabetta Patorno, Edward R Marcantonio
PURPOSE: To evaluate the performance of delirium-identification algorithms in administrative claims and drug utilization data. METHODS: We used data from a prospective study of 184 older adults who underwent aortic valve replacement at a single academic medical center to evaluate the following delirium-identification algorithms: (1) International Classification of Diseases (ICD) diagnosis codes for delirium; (2) antipsychotics use; (3) either ICD diagnosis codes or antipsychotics use; and (4) both ICD diagnosis codes and antipsychotics use...
May 9, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28484008/mtorc1-promotes-proliferation-of-immature-schwann-cells-and-myelin-growth-of-differentiated-schwann-cells
#20
Bogdan Beirowski, Keit Men Wong, Elisabetta Babetto, Jeffrey Milbrandt
The myelination of axons in peripheral nerves requires precisely coordinated proliferation and differentiation of Schwann cells (SCs). We found that the activity of the mechanistic target of rapamycin complex 1 (mTORC1), a key signaling hub for the regulation of cellular growth and proliferation, is progressively extinguished as SCs differentiate during nerve development. To study the effects of different levels of sustained mTORC1 hyperactivity in the SC lineage, we disrupted negative regulators of mTORC1, including TSC2 or TSC1, in developing SCs of mutant mice...
May 8, 2017: Proceedings of the National Academy of Sciences of the United States of America
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