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https://www.readbyqxmd.com/read/29138391/maternal-impulse-control-disability-and-developmental-disorder-traits-are-risk-factors-for-child-maltreatment
#1
Yoshiyuki Tachibana, Kenji Takehara, Naoko Kakee, Masashi Mikami, Eisuke Inoue, Rintaro Mori, Erika Ota, Tomoe Koizumi, Makiko Okuyama, Takahiko Kubo
Previous work has suggested that maternal developmental disorder traits related to autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are significantly associated with child maltreatment. However, there may be other important maternal characteristics that contribute to child maltreatment. We hypothesized that maternal impulse control disability may also affect child maltreatment in addition to maternal developmental disorder traits. We aimed to test this hypothesis via a cohort study performed in Tokyo (n = 1,260)...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29130145/late-onset-adhd-understanding-the-evidence-and-building-theoretical-frameworks
#2
REVIEW
Arthur Caye, Margaret H Sibley, James M Swanson, Luis Augusto Rohde
PURPOSE OF REVIEW: The traditional definition of Attention-Deficit/Hyperactivity Disorder (ADHD), assuming onset in childhood, has been challenged by evidence from four recent birth-cohort studies that reported most adults with ADHD lacked a childhood categorical ADHD diagnosis. RECENT FINDINGS: Late onset of symptoms was evaluated in the long-term follow-up of the Multimodal Treatment study of ADHD (MTA). In most cases, other factors were present that discounted the late onset of ADHD symptoms and excluded the diagnosis of ADHD...
November 13, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29121555/the-relationship-between-adhd-traits-and-sensory-sensitivity-in-the-general-population
#3
Maria Panagiotidi, Paul G Overton, Tom Stafford
Preliminary studies in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) report both hypo-responsiveness and hyper-responsiveness to sensory stimuli, as well as problems modulating sensory input. As it has been suggested that those with ADHD exist at the extreme end of a continuum of ADHD traits, which are also evident in the general population, we investigated the link between ADHD and sensory sensitivity in the general population. Two online questionnaires measuring ADHD traits and sensory responsivity across various sensory domains were administered to 234 participants...
October 25, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29112530/the-prevalence-of-psychiatric-disorders-and-mental-health-services-utilization-by-parents-and-relatives-living-with-individuals-with-autism-spectrum-disorders-in-puerto-rico
#4
Ernesto Magallón-Neri, Dorilyz Vila, Katyana Santiago, Pedro García, Glorisa Canino
Knowledge about prevalence rates of psychiatric disorders and mental health services use among parents and relatives of persons with autism spectrum disorder (ASD) is limited, particularly when referring to epidemiologic samples. The current study is based on an island-wide probabilistic multistage cluster sample of adult individuals (N = 3062) living in Puerto Rico. Results showed a significantly higher rate of attention deficit hyperactivity disorder and serious mental illness in parents (n = 34) or relatives (n = 34) of ASD individuals, as compared with the Puerto Rico adult population as a whole...
November 4, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29110954/effect-of-motor-subtypes-of-delirium-in-the-intensive-care-unit-on-fast-track-failure-after-cardiac-surgery
#5
Anna Lee, Jing Lan Mu, Chun Hung Chiu, Tony Gin, Malcolm John Underwood, Gavin Matthew Joynt
OBJECTIVE: The purpose of the study was to evaluate the association between motor subtypes of postoperative delirium in the intensive care unit and fast-track failure (a composite outcome of prolonged stay in the intensive care unit >48 hours, intensive care unit readmission, and 30-day mortality) after cardiac surgery. METHODS: This was a secondary analysis of a prospective cohort study of 600 consecutive adults undergoing cardiac surgery at a university hospital in Hong Kong (July 2013 to July 2015)...
September 30, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29108437/latent-profiles-of-early-developmental-vulnerabilities-in-a-new-south-wales-child-population-at-age-5%C3%A2-years
#6
Melissa J Green, Stacy Tzoumakis, Kristin R Laurens, Kimberlie Dean, Maina Kariuki, Felicity Harris, Nicole O'Reilly, Marilyn Chilvers, Sally A Brinkman, Vaughan J Carr
OBJECTIVE: Detecting the early emergence of childhood risk for adult mental disorders may lead to interventions for reducing subsequent burden of these disorders. We set out to determine classes of children who may be at risk for later mental disorder on the basis of early patterns of development in a population cohort, and associated exposures gleaned from linked administrative records obtained within the New South Wales Child Development Study. METHODS: Intergenerational records from government departments of health, education, justice and child protection were linked with the Australian Early Development Census for a state population cohort of 67,353 children approximately 5 years of age...
November 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29106438/the-neurocognitive-profile-of-attention-deficit-hyperactivity-disorder-a-review-of-meta-analyses
#7
Michelle A Pievsky, Robert E McGrath
Objective: Numerous meta-analyses have summarized studies comparing the neurocognitive performance of individuals with attention-deficit/hyperactivity disorder (ADHD) to that of healthy controls. Method: The present study is a systematic review and quantitative summary of those meta-analyses that aimed to determine the extent to which individuals with ADHD differ cognitively from typically developing controls. Results: Of 253 standardized mean differences (SMDs) drawn from 34 meta-analyses, 244 (96%) were positive, indicating better neurocognitive performance in the control group than the ADHD group...
July 6, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29104533/cell-type-specific-mrna-dysregulation-in-hippocampal-ca1-pyramidal-neurons-of-the-fragile-x-syndrome-mouse-model
#8
Laura Ceolin, Nathalie Bouquier, Jihane Vitre-Boubaker, Stéphanie Rialle, Dany Severac, Emmanuel Valjent, Julie Perroy, Emma Puighermanal
Fragile X syndrome (FXS) is a genetic disorder due to the silencing of the Fmr1 gene, causing intellectual disability, seizures, hyperactivity, and social anxiety. All these symptoms result from the loss of expression of the RNA binding protein fragile X mental retardation protein (FMRP), which alters the neurodevelopmental program to abnormal wiring of specific circuits. Aberrant mRNAs translation associated with the loss of Fmr1 product is widely suspected to be in part the cause of FXS. However, precise gene expression changes involved in this disorder have yet to be defined...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29099955/screening-for-adult-adhd-in-patients-with-fibromyalgia-syndrome
#9
Roland van Rensburg, Helgard Pieter Meyer, Sonia Anne Hitchcock, Christian Edward Schuler
Objective: Fibromyalgia syndrome (FMS) is a common chronic pain disorder associated with altered activity of neurotransmitters involved in pain sensitivity such as dopamine, serotonin, and noradrenaline. FMS may significantly impact an individual's functioning due to the presence of chronic pain, fatigue, and cognitive impairment. Dyscognition may be more disabling than the chronic pain but is mostly under-recognized. This study aimed to assess the potential co-occurrence of FMS and adult attention deficit hyperactivity disorder (ADHD), a chronic neurodevelopmental disorder also associated with impaired cognition and dopaminergic function...
November 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29098603/development-of-guanfacine-extended-release-dosing-strategies-in-children-and-adolescents-with-adhd-using-a-physiologically-based-pharmacokinetic-model-to-predict-drug-drug-interactions-with-moderate-cyp3a4-inhibitors-or-inducers
#10
Aiqun Li, Karen Yeo, Devin Welty, Haojing Rong
BACKGROUND: Guanfacine extended-release (GXR) is an orally administered, non-stimulant treatment for children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and is primarily metabolized by the 3A4 isozyme of cytochrome P450 (CYP3A4). The results of clinical pharmacokinetic (PK) studies indicate that guanfacine is sensitive to drug-drug interactions (DDIs) perpetrated by strong inhibitors and inducers of CYP3A4. OBJECTIVE: The aim was to provide guidance on the possible requirement for GXR dose adjustment in children and adolescents with ADHD by predicting DDIs following co-administration with moderate CYP3A4 inhibitors and inducers...
November 2, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/29098176/transient-prepubertal-mifepristone-treatment-normalizes-deficits-in-contextual-memory-and-neuronal-activity-of-adult-male-rats-exposed-to-maternal-deprivation
#11
Manila Loi, Ratna Angela Sarabdjitsingh, Andromachi Tsouli, Stephanie Trinh, Marit Arp, Harmen J Krugers, Henk Karst, Ruud van den Bos, Marian Joëls
Early life adversity is a well-known risk factor for behavioral dysfunction later in life, including the formation of contextual memory; it is also (transiently) accompanied by hyperactivity of the stress system. We tested whether mifepristone (MIF) treatment, which among other things blocks glucocorticoid receptors (GRs), during the prepubertal period [postnatal days (PND)26-PND28] normalizes memory deficits in adult male rats exposed to 24-h maternal deprivation (MD) at PND3. MD reduced body weight gain and increased basal corticosterone (CORT) levels during the PND26, but not in adulthood...
September 2017: ENeuro
https://www.readbyqxmd.com/read/29093440/quantitative-microscopy-of-the-drosophila-ovary-shows-multiple-niche-signals-specify-progenitor-cell-fate
#12
Wei Dai, Amy Peterson, Thomas Kenney, Haley Burrous, Denise J Montell
Adult stem cells commonly give rise to transit-amplifying progenitors, whose progeny differentiate into distinct cell types. It is unclear if stem cell niche signals coordinate fate decisions within the progenitor pool. Here we use quantitative analysis of Wnt, Hh, and Notch signalling reporters and the cell fate markers Eyes Absent (Eya) and Castor (Cas) to study the effects of hyper-activation and loss of niche signals on progenitor development in the Drosophila ovary. Follicle stem cell (FSC) progeny adopt distinct polar, stalk, and main body cell fates...
November 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/29090087/extended-release-methylphenidate-monotherapy-in-patients-with-comorbid-social-anxiety-disorder-and-adult-attention-deficit-hyperactivity-disorder-retrospective-case-series
#13
Ahmet Koyuncu, Fahri Çelebi, Erhan Ertekin, Burcu Ece Kök, Raşit Tükel
BACKGROUND: The relationship between social anxiety disorder (SAD) and attention-deficit/hyperactivity disorder (ADHD) is a subject which has recently become a topic of interest for research. METHODS: In this study, 20 patients with comorbid SAD and adult ADHD who were treated with extended-release methylphenidate monotherapy were evaluated retrospectively. RESULTS: Clinical response for both ADHD and SAD symptoms was observed in 17 of 20 patients...
November 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/29081022/adhd-symptoms-in-healthy-adults-are-associated-with-stressful-life-events-and-negative-memory-bias
#14
Janna N Vrijsen, Indira Tendolkar, Marten Onnink, Martine Hoogman, Aart H Schene, Guillén Fernández, Iris van Oostrom, Barbara Franke
Stressful life events, especially Childhood Trauma, predict ADHD symptoms. Childhood Trauma and negatively biased memory are risk factors for affective disorders. The association of life events and bias with ADHD symptoms may inform about the etiology of ADHD. Memory bias was tested using a computer task in N = 675 healthy adults. Life events and ADHD symptoms were assessed using questionnaires. The mediation of the association between life events and ADHD symptoms by memory bias was examined. We explored the roles of different types of life events and of ADHD symptom clusters...
October 28, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/29080396/neurobiological-support-to-the-diagnosis-of-adhd-in-stimulant-na%C3%A3-ve-adults-pattern-recognition-analyses-of-mri-data
#15
T M Chaim-Avancini, J Doshi, M V Zanetti, G Erus, M A Silva, F L S Duran, M Cavallet, M H Serpa, S C Caetano, M R Louza, C Davatzikos, G F Busatto
OBJECTIVE: In adulthood, the diagnosis of attention-deficit/hyperactivity disorder (ADHD) has been subject of recent controversy. We searched for a neuroanatomical signature associated with ADHD spectrum symptoms in adults by applying, for the first time, machine learning-based pattern classification methods to structural MRI and diffusion tensor imaging (DTI) data obtained from stimulant-naïve adults with childhood-onset ADHD and healthy controls (HC). METHOD: Sixty-seven ADHD patients and 66 HC underwent high-resolution T1-weighted and DTI acquisitions...
October 28, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29078281/multimodal-mapping-of-the-brain-s-functional-connectivity-and-the-adult-outcome-of-attention-deficit-hyperactivity-disorder
#16
Gustavo Sudre, Eszter Szekely, Wendy Sharp, Steven Kasparek, Philip Shaw
We have a limited understanding of why many children with attention deficit hyperactivity disorder do not outgrow the disorder by adulthood. Around 20-30% retain the full syndrome as young adults, and about 50% show partial, rather than complete, remission. Here, to delineate the neurobiology of this variable outcome, we ask if the persistence of childhood symptoms into adulthood impacts on the brain's functional connectivity. We studied 205 participants followed clinically since childhood. In early adulthood, participants underwent magnetoencephalography (MEG) to measure neuronal activity directly and functional MRI (fMRI) to measure hemodynamic activity during a task-free period (the "resting state")...
October 16, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29075206/abnormal-resting-state-functional-connectivity-of-insular-subregions-and-disrupted-correlation-with-working-memory-in-adults-with-attention-deficit-hyperactivity-disorder
#17
Qihua Zhao, Hui Li, Xiaoyan Yu, Fang Huang, Yanfei Wang, Lu Liu, Qingjiu Cao, Qiujin Qian, Yufeng Zang, Li Sun, Yufeng Wang
OBJECTIVES: Executive function (EF) deficits are major impairments in adults with attention deficit/hyperactivity disorder (ADHD). Previous studies have shown that the insula is involved in cognitive and EFs. However, the insula is highly heterogeneous in function, and few studies have focused on functional networks which related to specific insular subregions in adults with ADHD. We explored the functional networks of the insular subregions [anterior insula (AI), mid-insula (MI), and posterior insula (PI)]...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29073818/testing-the-discriminant-and-convergent-validity-of-the-world-health-organization-six-item-adult-adhd-self-report-scale-screener-using-the-stockholm-public-health-cohort
#18
Andreas Lundin, Kyriaki Kosidou, Christina Dalman
OBJECTIVE: The World Health Organization (WHO) Adult ADHD Self-Report Scale (ASRS) is intended to measure population prevalence of ADHD. The short version ASRS-6 has yet not been validated in a population setting. Our aim was to examine the validity of the ASRS-6 in a general population. METHOD: We used the Stockholm Public Health Cohort 2014. The convergent validity was assessed using item response theory (IRT). The discriminant validity was assessed by examining the correlation between the ASRS and known correlates...
October 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29063627/impulsive-personality-traits-mediate-the-relationship-between-adult-attention-deficit-hyperactivity-symptoms-and-alcohol-dependence-severity
#19
Allison M Daurio, Sean A Aston, Melanie L Schwandt, Mohammad O Bukhari, Sofia Bouhlal, Mehdi Farokhnia, Mary R Lee, Lorenzo Leggio
BACKGROUND: While the role of attention deficit hyperactivity disorder (ADHD) as a risk factor for developing alcohol use disorder (AUD) has been established, the underlying pathways connecting the two are still not fully understood. Overlapping constructs such as impulsivity may explain the increased risk for developing AUD in individuals with ADHD. METHODS: In this study, we assessed whether adult ADHD symptoms increase the odds of having a diagnosis of AUD. Furthermore, we tested whether facets of impulsivity explained the relationship between ADHD symptoms and alcohol dependence (AD) severity...
October 23, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29061293/methylphenidate-gender-trends-in-adult-and-pediatric-populations-over-a-7year-period
#20
Carole Ehrhardt, Quentin Boucherie, Vanessa Pauly, David Braunstein, Eléonore Ronflé, Xavier Thirion, Elisabeth Frauger, Joelle Micallef
OBJECTIVE: Methylphenidate (MPH) is a prescription-stimulant medication which is authorized in France for two indications: attention-deficit hyperactivity disorder in children (aged≥6years) and narcolepsy in cases where modafinil is ineffective (for children and adults). MPH use has increased worldwide in the past 2 decades in children and adults. Different pharmacoepidemiological Europeans studies have described MPH patterns of use. To our knowledge, few pharmacoepidemiological studies have described MPH patterns of use in France...
July 21, 2017: Thérapie
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