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Endoscopic myotomy

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https://www.readbyqxmd.com/read/28810541/microrna-130a-is-highly-expressed-in-the-esophageal-mucosa-of-achalasia-patients
#1
Hiroyuki Shoji, Hajime Isomoto, Akira Yoshida, Haruo Ikeda, Hitomi Minami, Tsutomu Kanda, Shigetoshi Urabe, Kayoko Matsushima, Fuminao Takeshima, Kazuhiko Nakao, Haruhiro Inoue
Esophageal achalasia is considered as a risk factor of esophageal cancer. The etiologies of esophageal achalasia remain unknown. Peroral endoscopic myotomy (POEM) has recently been established as a minimally invasive method with high curability. The aims of the present study were to identify the microRNAs (miRs) specific to esophageal achalasia, to determine their potential target genes and to assess their alteration following POEM. RNA was extracted from biopsy samples from middle esophageal mucosa and analyzed using a microarray...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28799145/a-third-myotomy-with-peroral-endoscopic-myotomy-after-two-failed-heller-myotomies
#2
Majidah Bukhari, Yamile Haito Chavez, Yen-I Chen, Olaya I Brewer Gutierrez, Mouen A Khashab
No abstract text is available yet for this article.
August 10, 2017: Endoscopy
https://www.readbyqxmd.com/read/28799005/per-oral-endoscopic-myotomy-poem-mid-term-efficacy-and-safety
#3
Martinek Jan, Svecova Hana, Vackova Zuzana, Dolezel Radek, Ngo Ondrej, Krajciova Jana, Kieslichova Eva, Janousek Radim, Pazdro Alexander, Harustiak Tomas, Zdrhova Lucie, Loudova Pavla, Stirand Petr, Spicak Julius
BACKGROUND AND AIMS: Per-oral endoscopic myotomy (POEM) is becoming a standard treatment for achalasia. Long-term efficacy and the rate of post-POEM reflux should be further investigated. The main aim of this study was to analyze safety and mid-term (12 and 24 months) clinical outcomes of POEM. METHODS: Data on single tertiary center procedures were collected prospectively. The primary outcome was treatment success defined as an Eckardt score < 3 at 12 and 24 months...
August 10, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28759929/gastric-peroral-endoscopic-myotomy-for-gastroparesis-after-botulinum-toxin-injection
#4
Monica Saumoy, Najib Nassani, Joaquin Ortiz, Viviana Parra, Amy Tyberg, Michel Kahaleh
No abstract text is available yet for this article.
July 31, 2017: Endoscopy
https://www.readbyqxmd.com/read/28759922/peroral-endoscopic-myotomy-poem-in-jackhammer-esophagus-a-trick-of-the-trade
#5
Enad Dawod, Monica Saumoy, Ming-Ming Xu, Michel Kahaleh
No abstract text is available yet for this article.
July 31, 2017: Endoscopy
https://www.readbyqxmd.com/read/28756484/distal-esophageal-spasm-with-multiple-esophageal-diverticula-successfully-treated-by-peroral-endoscopic-myotomy
#6
Koji Otani, Shinwa Tanaka, Fumiaki Kawara, Junichi Fujikawa, Akinari Sawada, Risa Uemura, Tetsuya Tanigawa, Toshio Watanabe, Takeshi Azuma, Yasuhiro Fujiwara
Distal esophageal spasm (DES) is a primary esophageal motility disorder. We encountered a rare case of DES accompanied by multiple esophageal diverticula. A 72-year-old woman complained of prolonged dysphagia and chest pain. A barium esophagogram showed multiple esophageal diverticula and significant contraction of the lower esophagus just above the cardia. Esophagogastroduodenoscopy revealed a corkscrew-like appearance, with spiral contractions and diverticula. High-resolution manometry revealed that the integrated relaxation pressure was normal; premature contractions were observed in ≥20% of the swallowing wave; the distal contractile integral was normal...
July 29, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28746968/-french-comment-on-article-submucosal-fibrosis-in-achalasia-patients-is-a-rare-cause-of-aborted-peroral-endoscopic-myotomy-procedures
#7
(no author information available yet)
No abstract text is available yet for this article.
August 2017: Endoscopy
https://www.readbyqxmd.com/read/28745833/full-layer-mucosal-histology-in-achalasia-histological-epithelial-wave-is-characteristic-in-pinstripe-pattern-positive-achalasia
#8
H Sato, K Takahashi, N Nakajima, G Hasegawa, K Mizuno, S Hashimoto, S Ikarashi, K Hayashi, Y Honda, J Yokoyama, Y Sato, S Terai
BACKGROUND: Previously, the mucosal histology in achalasia has only been investigated using superficial biopsy or surgically resected esophageal specimens in end-stage cases. We investigated the histology of the full-layer mucosa in early and advanced achalasia. METHODS: Endoscopy was performed for the pinstripe pattern (PSP) (an early achalasia indicator) and dilation and thickening of the mucosa (advanced achalasia indicators). A mucosal entry site for peroral endoscopic myotomy was created using cap-fitted endoscopic mucosal resection to access the full-layer mucosa and the submucosa...
July 26, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28738013/commentary-on-duan-et-al-a-retrospective-study-of-peroral-endoscopic-full-thickness-myotomy-in-patients-with-severe-achalasia
#9
Carlos Galvani
No abstract text is available yet for this article.
July 24, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28731572/endoscopic-surgical-technique-for-benign-fibrotic-strictures-of-the-upper-esophageal-sphincter
#10
Shun-Ichi Chitose, Kiminori Sato, Mioko Fukahori, Sachiyo Hamakawa, Akari Koga, Shintaro Sueyoshi, Hirohito Umeno
A 43-year-old man with complaints of increased difficulty of swallowing and weight loss underwent videofluorographic examination of swallowing, which revealed severely reduced cricopharyngeal opening. Endoscopic cricopharyngeal myotomy was performed using a modified technique (mECPM). A benign fibrotic stricture of the upper esophageal sphincter (UES) was identified under visualization of a distending operating laryngoscope. A vertical midline incision in the strictured mucosa and submucosal resection of the cricopharyngeal muscle were performed using a CO2 laser...
July 21, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28730348/-pharyngoesophageal-diverticulum
#11
C A Gutschow, P Bauerfeind
Over the last 20-30 years, treatment of pharyngoesophageal diverticula was subject to a number of fundamental changes. Considering the classical open transcervical approaches, the necessity for myotomy of the upper esophageal sphincter with the goal of interrupting the pathogenesis of the disease has become a standard component of the operation. On the other hand, with the growing popularity of rigid and flexible endoscopic techniques, pharyngoesophageal diverticula are increasingly being treated by gastroenterologists and otorhinolaryngologists, often with the argument of a technically easier and less invasive procedure; however, it remains unclear whether this shift towards endoscopic techniques truly translates into better outcome quality...
July 20, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28727260/gastric-per-oral-endoscopic-myotomy-g-poem-for-pylorospasm-case-report-and-literature-review
#12
Wen Wen Zheng, Ming Ming Zhang, Yan Zhang, Zhen Li, Xiu Li Zuo, Xue Feng Lu, Yan Qing Li
Gastric per oral endoscopic myotomy is a novel endoscopic technique, using mucosal incision and submucosal tunneling, to access and surgically divide the pyloric ring. It has been reported as a technically feasible procedure and minimally invasive therapy for refractory gastroparesis. We performed this procedure in a 63-year-old male patient with postoperative pylorospasm, with clinical success. Pylorospasm is one of pathophysiologic mechanisms underlying gastroparesis. As a subgroup of gastroparesis, pylorospasm should be identified to be an appropriate indication for gastric per oral endoscopic myotomy...
July 20, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28724307/per-oral-endoscopic-myotomy-poem-a-new-endoscopic-treatment-for-achalasia
#13
Pablo Miranda García, Fernando Casals Seoane, Jean-Michel Gonzalez, Marc Barthet, Cecilio Santander Vaquero
BACKGROUND/AIMS: Per-oral endoscopic myotomy (POEM) is a new minimally invasive technique to treat achalasia. METHODS: We performed a review of the literature of POEM with a special focus on technical details and the results obtained with this technique in patients with achalasia and other esophageal motility disorders. RESULTS: Thousands of POEM procedures have been performed worldwide since its introduction in 2008. The procedure is based on the creation of a mucosal entry point in the proximal esophagus to reach the cardia through a submucosal tunnel and then perform a myotomy of the muscular layers of the cardia, esophagogastric junction and distal esophagus, as performed in a Heller myotomy...
July 14, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28717439/achalasia-current-therapeutic-options
#14
REVIEW
Zubin Arora, Prashanthi N Thota, Madhusudhan R Sanaka
Achalasia is a chronic incurable esophageal motility disorder characterized by impaired lower esophageal sphincter (LES) relaxation and loss of esophageal peristalsis. Although rare, it is currently the most common primary esophageal motility disorder, with an annual incidence of around 1.6 per 100,000 persons and prevalence of around 10.8/100,000 persons. Symptoms of achalasia include dysphagia to both solids and liquids, regurgitation, aspiration, chest pain and weight loss. As the underlying etiology of achalasia remains unclear, there is currently no curative treatment for achalasia...
June 2017: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/28711287/in-vivo-experience-with-poem-an-essential-activity-for-developing-the-technique-in-humans
#15
A Peñaloza-Ramírez, J Suárez-Correa, J Báez-Blanco, C Sabogal-Gómez, H Kuan-Casas, C Sánchez-Pignalosa, P Aponte-Ordóñez
INTRODUCTION AND OBJECTIVES: Achalasia is the most widely studied esophageal motility disorder. No treatment has achieved completely satisfactory results. The laparoscopic Heller esophagomyotomy is currently the most accepted technique. With the advent of minimally invasive surgery, the appearance of peroral endoscopic submucosal myotomy (POEM) has promising results. The primary aim of our study was to perform peroral endoscopic esophagomyotomy in animal experimentation models to perfect the technique and later apply it to humans...
July 12, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28707343/peroral-endoscopic-myotomy-is-safe-and-effective-in-achalasia-patients-aged-older-than-60%C3%A2-years-compared-with-younger-patients
#16
Xiaowei Tang, Yutang Ren, Qiaoping Gao, Silin Huang, Jieqiong Zhou, Xiaofeng Zhang, Jianfeng Yang, Zhengjie Wei, Zhenyu Chen, Bo Jiang, Wei Gong
AIM: Peroral endoscopic myotomy (POEM) has been proven to be effective for treating achalasia, but there are limited data on POEM in elderly patients. We therefore aimed to assess the role of POEM for achalasia in patients aged ≥60 years. METHODS: All consecutive patients that underwent POEM between December 2011 and November 2015 at a single center were retrospectively reviewed. Patients aged ≥60 years were assigned to group A, whereas patients aged <60 years were assigned to group B...
July 14, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28702097/pediatric-achalasia-single-center-study-of-interventional-treatment
#17
Andrzej Grabowski, Wojciech Korlacki, Michał Pasierbek, Roksana Pułtorak, Filip Achtelik, Maciej Ilewicz
INTRODUCTION: Esophageal achalasia is a rare entity in children. However, young age is a factor of failure of conservative treatment, emphasizing the role of surgery. In our institution laparoscopic Heller's cardiomyotomy is the chosen procedure for surgical treatment. AIM: To assess the outcome of surgery for achalasia treatment in children operated on in a single institution. MATERIAL AND METHODS: A retrospective analysis of consecutive patient records from the years 1997 to 2014 was performed...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28691974/peroral-endoscopic-myotomy-in-children-with-achalasia-a-relatively-long-term-single-center-study
#18
Miao Shijian, Wu Jie, Lu Junping, Wang Yuhuan, Tang Zifei, Zhou Ying, Huang Zhiheng, Ying Huang, Zhou Pinghong
BACKGROUND: Achalasia is a disease caused by neuromuscular dysfunction in the esophagogastric junction, with a relatively low incidence among children. Peroral endoscopic myotomy (POEM) is a new endoscopic procedure for the treatment of achalasia, however it is rarely applied in children. OBJECTIVES: We aim to study the feasibility, safety, and effectiveness of POEM as a treatment for pediatric achalasia. METHODS: A total of 21 pediatric patients (aged from 11 months to 18 years) diagnosed with achalasia and treated with POEM from October of 2014 to October of 2016 in our hospital were included in our study...
July 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28691186/per-oral-endoscopic-myotomy-poem-as-a-salvation-technique-post-heller-an-international-experience
#19
Amy Tyberg, Reem Z Sharaiha, Pietro Familiari, Guido Costamagna, Fernando Casas, Nikhil A Kumta, Maximilien Barret, Amit P Desai, Felice Schnoll-Sussman, Payal Saxena, Guadalupe Martínez, Felipe Zamarripa, Monica Gaidhane, Helga Bertani, Peter V Draganov, Valerio Balassone, Ahmed Sharata, Kevin Reavis, Lee Swanstrom, Martina Invernizzi, Stefan Seewald, Hitomi Minami, Haruhiro Inoue, Michel Kahaleh
BACKGROUND: The treatment for achalasia has traditionally been Heller myotomy (HM). Despite its excellent efficacy rate, a number of patients remain symptomatic post-procedure. Limited data exists as to the best management for recurrence of symptoms post HM. We present an international, multicenter experience evaluating the efficacy and safety of post-HM per-oral endoscopic myotomy (POEM). METHODS: Patients who underwent a POEM post-HM from 13 centers from January 2012 to January 2017 were included as part of a prospective registry...
July 10, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28691051/peroral-endoscopic-myotomy-using-flushknife-bt-a-single-center-series
#20
Shinwa Tanaka, Takashi Toyonaga, Fumiaki Kawara, Ian S Grimm, Namiko Hoshi, Hirofumi Abe, Yoshiko Ohara, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma
BACKGROUND AND STUDY AIMS : Peroral endoscopic myotomy (POEM) is an evolving new treatment strategy for achalasia. Although several kinds of electrosurgical knives have been used in performing POEM, the best device has yet to be determined. The FlushKnife BT is a waterjet-emitting short needle-knife with a small ball tip (BT) that offers the potential to perform all aspects of POEM with a single device. In this study, we evaluated the safety and efficiency of the FlushKnife BT for POEM...
July 2017: Endoscopy International Open
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