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https://www.readbyqxmd.com/read/29245084/application-of-analytical-quality-by-design-principles-for-the-determination-of-alkyl-p-toluenesulfonates-impurities-in-aprepitant-by-hplc-validation-using-total-error-concept
#1
Constantinos K Zacharis, Elli Vastardi
In the research presented we report the development of a simple and robust liquid chromatographic method for the quantification of two genotoxic alkyl sulphonate impurities (namely methyl p-toluenesulfonate and isopropyl p-toluenesulfonate) in Aprepitant API substances using the Analytical Quality by Design (AQbD) approach. Following the steps of AQbD protocol, the selected critical method attributes (CMAs) were the separation criterions between the critical peak pairs, the analysis time and the peak efficiencies of the analytes...
December 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29244861/reliability-of-the-parameters-of-the-power-duration-relationship-using-maximal-effort-time-trials-under-laboratory-conditions
#2
Christoph Triska, Bettina Karsten, Bernd Heidegger, Bernhard Koller-Zeisler, Bernhard Prinz, Alfred Nimmerichter, Harald Tschan
The purpose of this study was to assess the reliability of critical power (CP) and the total amount of work accomplished above CP (W´) across repeated tests using ecologically valid maximal effort time-trials (TT) under laboratory conditions. After an initial incremental exercise test, ten well-trained male triathletes (age: 28.5 ± 4.7 years; body mass: 73.3 ± 7.9 kg; height: 1.80 ± 0.07 m; maximal aerobic power [MAP]: 329 ± 41 W) performed three testing sessions (Familiarization, Test I and Test II) each comprising three TT (12, 7, and 3 min with a passive recovery of 60 min between trials)...
2017: PloS One
https://www.readbyqxmd.com/read/29244505/drainage-from-a-fluid-handling-component-because-of-inclination
#3
C W Extrand
The onset of drainage of liquids from fluid-handling components with a single, circular orifice was evaluated. A component was filled with water, ethylene glycol, or ethyl alcohol and then oriented vertically with its orifice facing downward. The lower end of the component was slowly tilted toward the horizon. No flow occurred until a critical angle of inclination was reached. The onset of drainage was successfully modeled as a balance between the hydrostatic pressure in the bulk liquid and the Laplace pressure of the air-liquid interface within the orifice...
December 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29243501/critical-analysis-of-valuation-and-strategical-orientation-of-merger-and-acquisition-deals-in-the-pharmaceutical-industry
#4
Raphaela Marie Louisa Dierks, Olivier Bruyère, Jean-Yves Reginster
the pharmaceutical industry is undergoing major shifts due to changing macro and micro factors. As the industry is highly capital intensive and patents are expiring, the outlook is on generating inorganic growth, mainly through M&A. Using the income valuation approach, one analyses two completed deals in 2016 above 1bn USD. Thereafter one outlines the main motives behind M&A deals and concluded by discussing whether M&A harms medical innovations. Areas covered: the paper is based on empirical study questioning existing literature in order to critically analyse valuation and the strategical orientation of pharmaceutical companies Expert commentary: pharmaceutical companies understand the changing market conditions and favour their expertise...
December 15, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/29243483/relative-binding-free-energy-calculations-in-drug-discovery-recent-advances-and-practical-considerations
#5
Zoe Cournia, Bryce Allen, Woody Sherman
Accurate in silico prediction of protein-ligand binding affinities has been a primary objective of structure-based drug design for decades due to the putative value it would bring to the drug discovery process. However, computational methods have historically failed to deliver value in real-world drug discovery applications due to a variety of scientific, technical, and practical challenges. Recently, a family of approaches commonly referred to as relative binding free energy (RBFE) calculations, which rely on physics-based molecular simulations and statistical mechanics, have shown promise in reliably generating accurate predictions in the context of drug discovery projects...
December 15, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29243400/highly-efficient-gas-phase-oxidation-of-renewable-furfural-to-maleic-anhydride-over-plate-vpo-catalyst
#6
Yugen Zhang, Xiukai Li, Jogie Ko
Maleic anhydride (MAnh) and its acids are critical intermediates in chemical industry. The synthesis of maleic anhydride from renewable furfural is one of the most sought after processes in the field of sustainable chemistry. We report a plate vanadium phosphorous oxide (VPO) catalyst synthesized by a hydrothermal method with glucose as a green reducing agent for furfural oxidation to MAnh in gas phase. The plate VPOHT catalyst has a preferentially exposed 200 crystal plane and exhibited dramatically enhanced activity, selectivity and stability as compared to conventional VPO catalysts and other state-of-the-art catalytic systems...
December 15, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29242718/a-bayesian-assessment-of-real-world-behavior-during-multitasking
#7
Jeroen H M Bergmann, Joan Fei, David A Green, Amir Hussain, Newton Howard
Multitasking is common in everyday life, but its effect on activities of daily living is not well understood. Critical appraisal of performance for both healthy individuals and patients is required. Motor activities during meal preparation were monitored in healthy individuals with a wearable sensor network during single and multitask conditions. Motor performance was quantified by the median frequencies (fm) of hand trajectories and wrist accelerations. The probability that multitasking occurred based on the obtained motor information was estimated using a Naïve Bayes Model, with a specific focus on the single and triple loading conditions...
2017: Cognitive Computation
https://www.readbyqxmd.com/read/29242158/additively-manufactured-biodegradable-porous-magnesium
#8
Y Li, J Zhou, P Pavanram, M A Leeflang, L I Fockaert, B Pouran, N Tümer, K-U Schröder, J M C Mol, H Weinans, H Jahr, A A Zadpoor
An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully interconnected porous structure, and degrade in the human body to allow for full regeneration of large bony defects. However, simultaneously satisfying all these three requirements has so far been highly challenging. Here we present topologically ordered porous magnesium (WE43) scaffolds based on the diamond unit cell that were fabricated by selective laser melting (SLM) and satisfy all the requirements...
December 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29241524/validity-of-the-current-risk-assessment-scale-for-pressure-ulcers-in-intensive-care-evaruci-and-the-norton-mi-scale-in-critically-ill-patients
#9
Sara Lospitao-Gómez, Tomás Sebastián-Viana, José M González-Ruíz, Joaquín Álvarez-Rodríguez
OBJECTIVE: The objective of this study was to evaluate the validity of risk detection scales EVARUCI and Norton-MI (modified by INSALUD) to detect critical adult patients with the risk of developing pressure ulcers (PU) in an intensive care unit (ICU). DESIGN: The authors have conducted a descriptive, prospective study at the ICU in their hospital from 2008 to 2014. The evaluations of both scales were registered daily by nurses from the unit. PATIENTS: Adult patients admitted into the ICU...
December 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29240779/impact-of-maternal-high-fat-diet-on-hypothalamic-transcriptome-in-neonatal-sprague-dawley-rats
#10
Sanna Barrand, Tamsyn M Crowley, Ryan J Wood-Bradley, Kirstie A De Jong, James A Armitage
Maternal consumption of a high fat diet during early development has been shown to impact the formation of hypothalamic neurocircuitry, thereby contributing to imbalances in appetite and energy homeostasis and increasing the risk of obesity in subsequent generations. Early in postnatal life, the neuronal projections responsible for energy homeostasis develop in response to appetite-related peptides such as leptin. To date, no study characterises the genome-wide transcriptional changes that occur in response to exposure to high fat diet during this critical window...
2017: PloS One
https://www.readbyqxmd.com/read/29240684/optimal-multi-type-sensor-placement-for-structural-identification-by-static-load-testing
#11
Numa Joy Bertola, Maria Papadopoulou, Didier Vernay, Ian F C Smith
Assessing ageing infrastructure is a critical challenge for civil engineers due to the difficulty in the estimation and integration of uncertainties in structural models. Field measurements are increasingly used to improve knowledge of the real behavior of a structure; this activity is called structural identification. Error-domain model falsification (EDMF) is an easy-to-use model-based structural-identification methodology which robustly accommodates systematic uncertainties originating from sources such as boundary conditions, numerical modelling and model fidelity, as well as aleatory uncertainties from sources such as measurement error and material parameter-value estimations...
December 14, 2017: Sensors
https://www.readbyqxmd.com/read/29240627/extracorporeal-membrane-oxygenation-bridges-inoperable-patients-to-definitive-cardiac-operation
#12
Nikola Dobrilovic, Omar Lateef, Lauren Michalak, Maja Delibasic, Jaishankar Raman
Extracorporeal membrane oxygenation (ECMO) offers an opportunity for patient recovery through complete cardiopulmonary support but is associated with complications that limit duration and overall utility. We examine the role of ECMO as a potential bridge to high-risk cardiac surgery in otherwise inoperable cases. This study reports a retrospective, multi-institution experience examining all patients for whom ECMO was used preoperatively as a bridge to definitive cardiac surgery without exception. A consecutive patient database (December 2011 through August 2017) was utilized...
December 11, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29239899/stroke-severity-quantification-by-critical-care-physicians-in-a-mobile-stroke-unit
#13
Maren R Hov, Jo Røislien, Thomas Lindner, Erik Zakariassen, Kristi C G Bache, Volker M Solyga, David Russell, Christian G Lund
BACKGROUND: Cerebral revascularization in acute stroke requires robust diagnostic tools close to symptom onset. The quantitative National Institute of Health Stroke Scale (NIHSS) is widely used in-hospital, whereas shorter and less specific stroke scales are used in the prehospital field. This study explored the accuracy and potential clinical benefit of using NIHSS prehospitally. PATIENTS AND METHODS: Thirteen anesthesiologists trained in prehospital critical care enrolled patients with suspected acute stroke in a mobile stroke unit...
December 12, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/29239442/hydrodynamics-mediated-trapping-of-micro-swimmers-near-drops
#14
Nikhil Desai, Vaseem A Shaik, Arezoo M Ardekani
In this paper, we investigate the swimming characteristics and dynamics of a model micro-swimmer in the vicinity of a clean drop, and of a surfactant covered drop. We model the swimmer as a force dipole and utilize the image-singularity system to study the dynamical behavior of the swimmer. Motivated by bacterial bio-remediation of insoluble hydrocarbons (HCs) released during oil spills, we report the 'trapping characteristics' - critical trapping radius, basin of attraction and trapping time distribution - of deterministic and stochastic swimmers, as a function of viscosity ratio, and dimensionless surface viscosity...
December 14, 2017: Soft Matter
https://www.readbyqxmd.com/read/29239017/five-key-lncrnas-considered-as-prognostic-targets-for-predicting-pancreatic-ductal-adenocarcinoma
#15
Jukun Song, Qiuyan Yan, Haodeng Zhang, Xinhai Yin, Chen Zhu, Ke Zhao, Jianguo Zhu
To improve PDCA prognosis, a screening biomarker for early diagnosis of pancreatic cancer is in urgent need. Long non-coding RNA (lncRNA) expression profiles as potential cancer prognostic biomarkers play critical roles in development of tumorigenesis and metastasis of cancer. However, lncRNA signatures in predicting the survival of a patient with PDAC remain unknown. In the current study, we try to identify potential lncRNA biomarkers and their prognostic values in PDAC. LncRNAs expression profiles and corresponding clinical information for 182 cases with PDAC were acquired from The Cancer Genome Atlas (TCGA)...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29238236/pro-gastrin-releasing-peptide-progrp-as-a-biomarker-in-small-cell-lung-cancer-diagnosis-monitoring-and-evaluation-of-treatment-response
#16
REVIEW
Ewa Wojcik, Jan Kanty Kulpa
Lung cancer belongs to malignant tumors that possess the highest rates of morbidity and mortality in the world. A number of morphological, biological and clinical features justify the distinction of small-cell carcinoma with respect to the other histological types of lung cancer. The predominant neuroendocrine phenotype is critical for the selection of biomarkers used in diagnostics, monitoring and evaluation of treatment response; early onset relapses in patients with small-cell lung cancer (SCLC) and the evaluation of their prognosis...
2017: Lung Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29236947/earliness-traits-in-rapeseed-brassica-napus-snp-loci-and-candidate-genes-identified-by-genome-wide-association-analysis
#17
Qinghong Zhou, Depeng Han, Annaliese S Mason, Can Zhou, Wei Zheng, Yazhen Li, Caijun Wu, Donghui Fu, Yingjin Huang
Life cycle timing is critical for yield and productivity of Brassica napus (rapeseed) cultivars grown in different environments. To facilitate breeding for earliness traits in rapeseed, SNP loci and underlying candidate genes associated with the timing of initial flowering, maturity and final flowering, as well as flowering period (FP) were investigated in two environments in a diversity panel comprising 300 B. napus inbred lines. Genome-wide association studies (GWAS) using 201,817 SNP markers previously developed from SLAF-seq (specific locus amplified fragment sequencing) revealed a total of 131 SNPs strongly linked (P < 4...
December 11, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/29236900/influence-of-implantoplasty-on-stress-distribution-of-exposed-implants-at-different-bone-insertion-levels
#18
João Paulo Mendes Tribst, Amanda Maria de Oliveira Dal Piva, Jamil Awad Shibli, Alexandre Luiz Souto Borges, Rubens Nisie Tango
This study evaluated the effect of implantoplasty on different bone insertion levels of exposed implants. A model of the Bone Level Tapered implant (Straumann Institute, Waldenburg, Switzerland) was created through the Rhinoceros software (version 5.0 SR8, McNeel North America, Seattle, WA, USA). The abutment was fixed to the implant through a retention screw and a monolithic crown was modeled over a cementation line. Six models were created with increasing portions of the implant threads exposed: C1 (1 mm), C2 (2 mm), C3 (3 mm), C4 (4 mm), C5 (5 mm) and C6 (6 mm)...
December 7, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/29236864/biomarkers-as-predictors-of-mortality-in-critically-ill-patients-with-solid-tumors
#19
Audrey M Dos Reis, Ana V G Fruchtenicht, Luiza C DE Athaydes, Sérgio Loss, Luis Fernando Moreira
Biochemical markers produced by the affected organ or body in response to disease have gained high clinical value due to assess disease development and being excellent predictors of morbidity and mortality. The aim of this study is to analyze different biochemical markers in critically cancer patients and to determine which of them can be used as predictors of mortality. This is a prospective, cross-sectional study conducted at a University Hospital in Porto Alegre - RS. Screening was done to include patients in the study...
December 11, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29236650/perspective-on-publishing-quality-improvement-efforts
#20
Michael Kanter, Patrick T Courneya
Quality improvement (QI) activities are critical to achieve the Triple Aim and to the Institute of Medicine's six "Aims for Quality Improvement": Safe, Effective, Patient-Centered, Timely, Efficient, and Equitable. These QI activities are essential to create a learning health care system. Academic publishing is critical to foster continuous QI and sharing, and yet it tends to favor more traditional research articles. Publishing QI activities has great value, encourages greater rigor, and helps facilitate greater willingness to share improvement opportunities...
2017: Permanente Journal
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