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https://www.readbyqxmd.com/read/29475205/the-pituitary-thyroid-axis-and-prolactin-secretion-in-hemodialysis-patients-in-two-endemic-regions-of-eastern-germany
#1
Franz Maximilian Rasche, Ronny Rettig, Thomas Frese, Wilma Gertrud Rasche, Filip Barinka, Guenter Roesl, Frieder Keller, Tom H Lindner, Jochen G Schneider, Joachim Beige, Thomas Ebert, Stephan Schiekofer
INTRODUCTION: Endocrine disorders of the pituitary axes are frequent in patients with hemodialysis (CKD5D). The aim of this multicenter study (Leipzig (L), Quedlinburg and Blankenburg in the Harz region (Hz)) in CKD5D patients was to evaluate influences of CKD5D related factors, morphological and biochemical parameters, and serum iodine and prolactin concentrations on the pituitary-thyroid axis. PATIENTS AND METHODS: 170 patients (L n=58; Hz n=112) were included in this prospective, non-interventional, cross-sectional study...
February 23, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29475168/spontaneous-mesenteric-hematoma-of-the-sigmoid-colon-associated-with-rivaroxaban-a-case-report
#2
Katsuhisa Hirano, Tadashi Bando, Soshi Osawa, Tetsuro Shimizu, Tomoyuki Okumura, Tsutomu Fujii
INTRODUCTION: Mesenteric hematoma is a rare condition caused by bleeding localized in the mesenteric vascular tree. This is a first report of spontaneous mesenteric hematoma caused by rivaroxaban. PRESENTATION OF CASE: The patient was a 71-year-old man who had taken rivaroxaban for paroxysmal atrial fibrillation. He had experienced abdominal pain and diarrhea for the prior 3 days. He had little melena and was referred to our institute. He presented with hypotension on arrival...
February 10, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29474985/optimal-reference-gene-selection-for-expression-studies-in-human-reticulocytes
#3
Anu Aggarwal, Manu Jamwal, Ganesh Kumar V, Prashant Sharma, Man Updesh Singh Sachdeva, Deepak Bansal, Pankaj Malhotra, Reena Das
Reference genes are indispensable for normalizing mRNA levels across samples in real-time quantitative PCR. Their expression levels vary under different experimental conditions and due to several inherent characteristics. Appropriate reference gene selection is thus critical for gene-expression studies. This study aimed at selecting optimal reference genes for gene-expression analysis of reticulocytes and validating them in hereditary spherocytosis (HS) and β-thalassemia intermedia (βTI) patients. Seven reference genes (PGK1, MPP1, HPRT1, ACTB, GAPDH, RN18S1, and SDHA) were selected from published literature...
February 20, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29474506/derivation-of-outcome-based-pediatric-critical-values
#4
Hao Du, Corey Markus, Michael Metz, Mengling Feng, Tze Ping Loh
Objectives: There is currently a lack of an outcomes-based definition of critical values for the pediatric population. This has contributed to a highly heterogeneous critical value reporting practice between laboratories. Methods: Anonymized results were extracted from a laboratory information system for 10 biochemistry tests. The probability of high-dependency/intensive care unit admission (as a proxy for adverse outcomes) for each individual laboratory concentration was calculated and adjusted to fit using a polynomial function to model the probability trend...
February 21, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29474336/endothelial-cell-specific-molecule-1-in-critically-ill-patients-with-hematologic-malignancy
#5
Lara Zafrani, Matthieu Resche-Rigon, Nathalie De Freitas Caires, Alexandre Gaudet, Daniel Mathieu, Erika Parmentier-Decrucq, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, François Vincent, Martine N'yunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Michael Darmon, Elie Azoulay
OBJECTIVES: To assess whether serum concentration of endothelial cell-specific molecule-1 (Endocan) at ICU admission is associated with the use of ICU resources and outcomes in critically ill hematology patients. DESIGN: Prospective multicenter cohort study. SETTING: Seventeen ICUs in France and Belgium. PATIENTS: Seven hundred forty-four consecutive critically ill hematology patients; 72 critically ill septic patients without hematologic malignancy; 276 healthy subjects...
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29473297/promoting-collaboration-in-emergency-medicine
#6
Shobhana Nagraj, Juliet Harrison, Lawrence Hill, Lesley Bowker, Susanne Lindqvist
BACKGROUND: Collaborative practice between paramedics and medical staff is essential for ensuring the safe handover of patients. Handover of care is a critical time in the patient journey, when effective communication and collaborative practice are central to promoting patient safety and to avoiding medical error. To encourage effective collaboration between paramedic and medical students, an innovative, practice-based simulation exercise, known as interprofessional clinical skills (ICS) was developed at the University of East Anglia, UK...
February 23, 2018: Clinical Teacher
https://www.readbyqxmd.com/read/29472783/performance-evaluation-of-chrysopogon-zizanoides-under-urban-conditions-of-kuwait
#7
Majda Khalil Suleiman, Narayana Ramachandra Bhat, Sheena Jacob, Meali Al-Burais
Plant physiological and morphological attributes should be critically evaluated for selecting any species for landscaping projects. The selection of a species should be based on the evaluation of its adaptability, noninvasiveness, growth potential, and performance under the prevailing local arid conditions for their aesthetic looks, soil stabilization, and afforestation values. Chrysopogon zizanoides (Vetiver), is suitable for Kuwait because it can withstand fluctuating temperatures ranging from -14 to 55 °C with unique physical and physiological characteristics...
February 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29472718/pharmacologic-inhibition-of-stat5-in-acute-myeloid-leukemia
#8
Bettina Wingelhofer, Barbara Maurer, Elizabeth C Heyes, Abbarna A Cumaraswamy, Angelika Berger-Becvar, Elvin D de Araujo, Anna Orlova, Patricia Freund, Frank Ruge, Jisung Park, Gary Tin, Siawash Ahmar, Charles-Hugues Lardeau, Irina Sadovnik, Dávid Bajusz, György Miklós Keserű, Florian Grebien, Stefan Kubicek, Peter Valent, Patrick T Gunning, Richard Moriggl
The transcription factor STAT5 is an essential downstream mediator of many tyrosine kinases (TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which is a constitutively active TK driving the pathogenesis of acute myeloid leukemia (AML). Since STAT5 is a critical mediator of diverse malignant properties of AML cells, direct targeting of STAT5 is of significant clinical value. Here, we describe the development and preclinical evaluation of a novel, potent STAT5 SH2 domain inhibitor, AC-4-130, which can efficiently block pathological levels of STAT5 activity in AML...
February 2, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29472632/african-swine-fever-virus-encodes-for-an-e2-ubiquitin-conjugating-enzyme-that-is-mono-and-di-ubiquitinated-and-required-for-viral-replication-cycle
#9
Ferdinando B Freitas, Gonçalo Frouco, Carlos Martins, Fernando Ferreira
African swine fever virus is the etiological agent of a contagious and fatal acute haemorrhagic viral disease for which there are no vaccines or therapeutic options. The ASFV encodes for a putative E2 ubiquitin conjugating enzyme (ORF I215L) that shows sequence homology with eukaryotic counterparts. In the present study, we showed that pI215L acts as an E2-ubiquitin like enzyme in a large range of pH values and temperatures, after short incubation times. Further experiments revealed that pI215L is polyubiquitinated instead of multi-mono-ubiquitinated and Cys85 residue plays an essential role in the transthioesterification reaction...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29471749/comparing-mentorship-and-sponsorship-in-clinical-neuropsychology
#10
Robin C Hilsabeck
OBJECTIVE: Mentoring is a well-known concept that is widely regarded as beneficial for personal and professional development. The concept of sponsoring is less recognized although it is considered critical by some for career advancement. The purpose of this study was to provide an initial exploration of differences between mentoring and sponsoring within neuropsychology and to learn what sponsors look for in protégés. METHOD: Twenty neuropsychologists with experience in mentorship and sponsorship were interviewed...
February 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29471736/incursions-from-the-epicentre-southern-theory-social-science-and-the-global-hiv-research-domain
#11
Rebecca Hodes, Robert Morrell
Research about HIV constitutes a global domain of academic knowledge. The patterns that structure this domain reflect inequalities in the production and dissemination of knowledge, as well as broader inequalities in geopolitics. Conventional metrics for assessing the value and impact of academic research reveal that "Northern" research remains dominant, while "Southern" research remains peripheral. Southern theory provides a framework for greater critical engagement with knowledge produced by researchers within the global South...
February 22, 2018: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29471323/what-s-to-be-done-about-laboratory-quality-process-indicators-laboratory-stewardship-the-outcomes-problem-risk-assessment-and-economic-value-responding-to-contemporary-global-challenges
#12
Frederick A Meier, Tony C Badrick, Kenneth A Sikaris
Objectives: For 50 years, structure, process, and outcomes measures have assessed health care quality. For clinical laboratories, structural quality has generally been assessed by inspection. For assessing process, quality indicators (QIs), statistical monitors of steps in the clinical laboratory total testing, have proliferated across the globe. Connections between structural and process laboratory measures and patient outcomes, however, have rarely been demonstrated. Methods: To inform further development of clinical laboratory quality systems, we conducted a selective but worldwide review of publications on clinical laboratory quality assessment...
February 17, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29470047/heterostructured-nanorings-of-fe-fe3o4-c-hybrid-with-enhanced-microwave-absorption-performance
#13
Xian Jian, Xiangyun Xiao, Longjiang Deng, Wei Tian, Xin Wang, Nasir Mahmood, Shixue Dou
Microwave absorption is a critical challenge with progression in electronics, where fine structural designing of absorbent materials plays an effective role in optimizing their microwave absorption properties. Here, we have developed Fe3O4@C (FC) and Fe-Fe3O4@C (FFC) hybrid nanorings via hydrothermal method coupled with chemical catalytic vapour deposition (CCVD) technique. FC and FFC hybrid nanorings have fine carbon coating while their size can easily be tuneable in a certain range from 80~130 nm and 90~140 nm, respectively...
February 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29469999/a-systematic-review-and-meta-analysis-of-baseline-ohip-edent-scores
#14
J M J Duale, Y A Patel, J Wu, T P Hyde
BACKGROUND: OHIP-EDENT is widely used in the literature to assess Oral-Health-Related-Quality-of-Life (OHRQoL) for edentulous patients. However the normal variance and mean of the baseline OHIP scores has not been reported. It would facilitate critical appraisal of studies if we had knowledge of the normal variation and mean of baseline OHIP-EDENT scores. An established figure for baseline OHIP-EDENT, obtained from a meta-analysis, would simplify comparisons of studies and quantify variations in initial OHRQoL of the trial participants...
February 20, 2018: Community Dental Health
https://www.readbyqxmd.com/read/29469955/variability-of-symmetric-dimethylarginine-in-apparently-healthy-dogs
#15
M A Kopke, R K Burchell, C G Ruaux, S E Burton, N Lopez-Villalobos, A Gal
BACKGROUND: Symmetric dimethylarginine (SDMA) is a screening tool for early kidney dysfunction and monitoring treatment in cases of chronic kidney disease (CKD). There are no current studies describing the suitability of this test for use with published population-based reference intervals. HYPOTHESIS/OBJECTIVES: To determine the components of biological variability, the index of individuality (IOI), the critical difference between sequential measurements (CD ) and the number of measurements required to assess the homeostatic set point (HSP), for both SDMA and serum creatinine (sCr), in apparently healthy dogs...
February 22, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29469246/reflective-practices-meaningful-recognition-for-healthy-work-environments
#16
Gwen Sherwood, Usha Koshy Cherian, Sara Horton-Deutsch, Rebecca Kitzmiller, Cheryl Smith-Miller
Nurses' decisions about their intent to remain in the workforce are based on various factors. A healthy work environment in which work done well is recognised and appreciated contributes to nurses' satisfaction and better patient outcomes. This article examines the American Association of Critical-Care Nurses framework for a healthy work environment, focusing on standards for meaningful recognition. Reflective practice, which provides a self-analytical approach to appreciate and value one's work, is viewed as self-recognition...
February 22, 2018: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/29468335/use-of-speckle-tracking-strain-in-preload-dependent-patients-need-for-cautious-interpretation
#17
C Nafati, M Gardette, M Leone, L Reydellet, V Blasco, A Lannelongue, F Sayagh, S Wiramus, F Antonini, J Albanèse, L Zieleskiewicz
BACKGROUND: In critical patients, left ventricular ejection fraction and fractional shortening are used to reflect left ventricular systolic function. An emerging technique, two-dimensional-strain echocardiography, allows assessment of the left ventricle systolic longitudinal deformation (global longitudinal strain) and the speed at which this deformation occurs (systolic strain rate). This technique is of increasing use in critical patients in intensive care units and in the peri-operative period where preload constantly varies...
February 21, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29468184/translational-potential-of-human-brain-organoids
#18
Alfred X Sun, Huck-Hui Ng, Eng-King Tan
The recent technology of 3D cultures of cellular aggregates derived from human stem cells have led to the emergence of tissue-like structures of various organs including the brain. Brain organoids bear molecular and structural resemblance with developing human brains, and have been demonstrated to recapitulate several physiological and pathological functions of the brain. Here we provide an overview of the development of brain organoids for the clinical community, focusing on the current status of the field with an critical evaluation of its translational value...
February 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29465729/ballistic-impact-response-of-lipid-membranes
#19
Yao Zhang, Zhaoxu Meng, Xin Qin, Sinan Keten
Therapeutic agent loaded micro and nanoscale particles as high-velocity projectiles can penetrate cells and tissues, thereby serving as gene and drug delivery vehicles for direct and rapid internalization. Despite recent progress in developing micro/nanoscale ballistic tools, the underlying biophysics of how fast projectiles deform and penetrate cell membranes is still poorly understood. To understand the rate and size-dependent penetration processes, we present coarse-grained molecular dynamics simulations of the ballistic impact of spherical projectiles on lipid membranes...
February 21, 2018: Nanoscale
https://www.readbyqxmd.com/read/29465631/near-infrared-cerebral-oximetry-to-predict-outcome-after-pediatric-cardiac-surgery-a-prospective-observational-study
#20
Marine Flechet, Fabian Güiza, Dirk Vlasselaers, Lars Desmet, Stoffel Lamote, Heidi Delrue, Marc Beckers, Michaël P Casaer, Pieter Wouters, Greet van den Berghe, Geert Meyfroidt
OBJECTIVES: To assess whether near-infrared cerebral tissue oxygen saturation, measured with the FORESIGHT cerebral oximeter (CAS Medical Systems, Branford, CT) predicts PICU length of stay, duration of invasive mechanical ventilation, and mortality in critically ill children after pediatric cardiac surgery. DESIGN: Single-center prospective, observational study. SETTING: Twelve-bed PICU of a tertiary academic hospital. PATIENTS: Critically ill children and infants with congenital heart disease, younger than 12 years old, admitted to the PICU between October 2012 and November 2015...
February 19, 2018: Pediatric Critical Care Medicine
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