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https://www.readbyqxmd.com/read/28813085/curcumin-decreases-astrocytic-reaction-after-gliotoxic-injury-in-the-rat-brainstem
#1
Eduardo Bondan, Carolina Cardoso, Maria de Fátima Martins
Recent studies have demonstrated that curcumin (Cur) has antioxidant, anti-inflammatory and anti-fibrotic effects. Ethidium bromide (EB) injections into the central nervous system (CNS) are known to induce local oligodendroglial and astrocytic loss, resulting in primary demyelination and neuroinflammation. Peripheral astrogliosis is seen around the injury site with increased immunoreactivity to glial fibrillary acidic protein (GFAP). This investigation aimed to evaluate the effect of Cur administration on astrocytic response following gliotoxic injury...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28813074/oral-narrative-of-individuals-with-fetal-alcohol-spectrum-disorder
#2
Giulia Ganthous, Natalia Freitas Rossi, Célia Maria Giacheti
Purpose: To investigate and compare the oral narrative of individuals with FASD and individuals with typical language development (TLD), as well as to correlate the narrative performance with the score from 4-Digit Diagnostic Code. Methods: Participants were 20 individuals with FASD, of both genders, with chronological age between 6 and 16 years, and 20 individuals with TLD, same gender and similar to the FASD group in age and socioeconomic status. The oral narrative was elicited using the book Frog, where are you? and the data were analyzed in terms of macrostructure, microstructure and global coherence level...
August 10, 2017: CoDAS
https://www.readbyqxmd.com/read/28813067/total-syntheses-of-smenothiazoles-a-and-b
#3
Xiao Ma, Yajie Chen, Sigui Chen, Zhengshuang Xu, Tao Ye
Concise total syntheses of smenothiazoles A (1) and B (2), two distinguished vinyl chloride containing natural products isolated from the marine sponge S. aurea, have been developed. Silastannation, Stille reaction and a carefully controlled desilylchlorination were employed as key steps to construct unique polyketide acid fragments, and the optimized reaction conditions avoided migration of 2,5-diene to a 2,4-conjugated system. This report unambiguously confirmed the structures of both natural products.
August 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28813055/multivesicular-droplets-a-cell-model-system-to-study-compartmentalised-biochemical-reactions
#4
N Nuti, P E Verboket, P S Dittrich
Multivesicular vesicles (MVVs) are artificial liposomal structures widely used as a platform to study the compartmentalisation of cells and as a scaffold for artificial cell/protocell models. Current preparation techniques for MVVs, however, offer poor control on the size, lamellarity, and loading of inner lipid vesicles. Here, we introduce a microfluidic device for the production of multivesicular droplets (MVDs): a novel model system combining the ease of use and control of droplet microfluidics with the biological relevance of MVVs...
August 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28813050/on-surface-synthesis-of-heptacene-and-its-interaction-with-a-metal-surface
#5
Malte Zugermeier, Manuel Gruber, Martin Schmid, Benedikt P Klein, Lukas Ruppenthal, Philipp Müller, Ralf Einholz, Wolfgang Hieringer, Richard Berndt, Holger F Bettinger, J Michael Gottfried
Heptacene was generated by surface-assisted didecarbonylation of an α-diketone precursor on a Ag(111) surface. Monitoring of the surface reaction and characterization of the adsorbed heptacene was performed with scanning tunneling microscopy (STM), X-ray photoelectron spectroscopy (XPS), near-edge X-ray absorption fine structure (NEXAFS) spectroscopy, and density functional theory (DFT) calculations. The surface-assisted formation of heptacene occurs around 460 K. Both the heptacene and the precursor molecules are oriented along the high-symmetry directions of the (111) surface and their molecular π systems face towards the substrate...
August 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/28813046/cold-atom-atom-ion-three-body-recombination-of-4-he-4-he-x-x-h-or-d
#6
Bin-Bin Wang, Yong-Chang Han, Wei Gao, Shu-Lin Cong
The atom-atom-ion three-body recombination (TBR) of mixed (4)He and X(-) (X = H or D) systems is investigated by solving the Schrödinger equation using the adiabatic hyperspherical representation method. It is shown that the dominant products after a TBR in the ultracold limit (E ≤ 0.1 mK × kB) are different for the two systems. For the (4)He(4)HeH(-) system, the rate of TBR into the (4)HeH(-) ion is nearly two orders of magnitude larger than that of TBR into the neutral (4)He2 molecule. In contrast, the yield of (4)He2 is a little higher than that of (4)HeD(-) for the (4)He(4)HeD(-) system...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28813042/the-carotenoid-pathway-what-is-important-for-excitation-quenching-in-plant-antenna-complexes
#7
Kieran F Fox, Vytautas Balevičius, Jevgenij Chmeliov, Leonas Valkunas, Alexander V Ruban, Christopher D P Duffy
Plant light-harvesting is regulated by the Non-Photochemical Quenching (NPQ) mechanism involving the reversible formation of excitation quenching sites in the Photosystem II (PSII) antenna in response to high light. While the major antenna complex, LHCII, is known to be a site of NPQ, the precise mechanism of excitation quenching is not clearly understood. A preliminary model of the quenched crystal structure of LHCII implied that quenching arises from slow energy capture by Car pigments. It predicted a thoroughly quenched system but offered little insight into the defining aspects of this quenching...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28813033/a-vision-based-wayfinding-system-for-visually-impaired-people-using-situation-awareness-and-activity-based-instructions
#8
Eunjeong Ko, Eun Yi Kim
A significant challenge faced by visually impaired people is 'wayfinding', which is the ability to find one's way to a destination in an unfamiliar environment. This study develops a novel wayfinding system for smartphones that can automatically recognize the situation and scene objects in real time. Through analyzing streaming images, the proposed system first classifies the current situation of a user in terms of their location. Next, based on the current situation, only the necessary context objects are found and interpreted using computer vision techniques...
August 16, 2017: Sensors
https://www.readbyqxmd.com/read/28813018/biophysical-and-computational-studies-of-the-vcci-vmip-ii-complex
#9
Anna F Nguyen, Nai-Wei Kuo, Laura J Showalter, Ricardo Ramos, Cynthia M Dupureur, Michael E Colvin, Patricia J LiWang
Certain viruses have the ability to subvert the mammalian immune response, including interference in the chemokine system. Poxviruses produce the chemokine binding protein vCCI (viral CC chemokine inhibitor; also called 35K), which tightly binds to CC chemokines. To facilitate the study of vCCI, we first provide a protocol to produce folded vCCI from Escherichia coli (E. coli.) It is shown here that vCCI binds with unusually high affinity to viral Macrophage Inflammatory Protein-II (vMIP-II), a chemokine analog produced by the virus, human herpesvirus 8 (HHV-8)...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28813017/a-wireless-exg-interface-for-patch-type-ecg-holter-and-emg-controlled-robot-hand
#10
Kwangmuk Lee, Yun Young Choi, Dae Jung Kim, Hee Young Chae, Kyeonghwan Park, Young Min Oh, Sung Hun Woo, Jae Joon Kim
This paper presents a wearable electrophysiological interface with enhanced immunity to motion artifacts. Anti-artifact schemes, including a patch-type modular structure and real-time automatic level adjustment, are proposed and verified in two wireless system prototypes of a patch-type electrocardiogram (ECG) module and an electromyogram (EMG)-based robot-hand controller. Their common ExG readout integrated circuit (ROIC), which is reconfigurable for multiple physiological interfaces, is designed and fabricated in a 0...
August 16, 2017: Sensors
https://www.readbyqxmd.com/read/28813015/transcriptional-responses-of-creeping-bentgrass-to-2-3-butanediol-a-bacterial-volatile-compound-bvc-analogue
#11
Yi Shi, Kuiju Niu, Bingru Huang, Wenhui Liu, Huiling Ma
Bacterial volatile compounds (BVCs) have been reported to enhance plant growth and elicit plant defenses against fungal infection and insect damage. The objective of this study was to determine transcriptomic changes in response to synthetic BVC that could be associated with plant resistance to Rhizoctonia solani in creeping bentgrass. The 2,3-butanediol (BD) (250 µM) was sprayed on creeping bentgrass leaves grown in jam jars. The result showed that synthetic BD induced plant defense against R. solani for creeping bentgrass...
August 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28812998/a-framework-based-on-reference-data-with-superordinate-accuracy-for-the-quality-analysis-of-terrestrial-laser-scanning-based-multi-sensor-systems
#12
Ulrich Stenz, Jens Hartmann, Jens-André Paffenholz, Ingo Neumann
Terrestrial laser scanning (TLS) is an efficient solution to collect large-scale data. The efficiency can be increased by combining TLS with additional sensors in a TLS-based multi-sensor-system (MSS). The uncertainty of scanned points is not homogenous and depends on many different influencing factors. These include the sensor properties, referencing, scan geometry (e.g., distance and angle of incidence), environmental conditions (e.g., atmospheric conditions) and the scanned object (e.g., material, color and reflectance, etc...
August 16, 2017: Sensors
https://www.readbyqxmd.com/read/28812994/organ-organ-crosstalk-and-alcoholic-liver-disease
#13
REVIEW
Lauren G Poole, Christine E Dolin, Gavin E Arteel
Alcohol consumption is a common custom worldwide, and the toxic effects of alcohol on several target organs are well-understood. Given the poor prognosis of treating clinically-relevant alcoholic liver disease (ALD) (i.e., alcoholic hepatitis (AH) and cirrhosis), additional research is required to develop more effective therapies. While the stages of ALD have been well-characterized, targeted therapies to prevent or reverse this process in humans are still needed. Better understanding of risk factors and mechanisms underlying disease progression can lead to the development of rational therapies to prevent or reverse ALD in the clinic...
August 16, 2017: Biomolecules
https://www.readbyqxmd.com/read/28812989/small-smart-fast-and-cheap-microchip-based-sensors-to-estimate-air-pollution-exposures-in-rural-households
#14
Ajay Pillarisetti, Tracy Allen, Ilse Ruiz-Mercado, Rufus Edwards, Zohir Chowdhury, Charity Garland, L Drew Hill, Michael Johnson, Charles D Litton, Nicholas L Lam, David Pennise, Kirk R Smith
Over the last 20 years, the Kirk R. Smith research group at the University of California Berkeley-in collaboration with Electronically Monitored Ecosystems, Berkeley Air Monitoring Group, and other academic institutions-has developed a suite of relatively inexpensive, rugged, battery-operated, microchip-based devices to quantify parameters related to household air pollution. These devices include two generations of particle monitors; data-logging temperature sensors to assess time of use of household energy devices; a time-activity monitoring system using ultrasound; and a CO₂-based tracer-decay system to assess ventilation rates...
August 16, 2017: Sensors
https://www.readbyqxmd.com/read/28812964/the-national-trust-a-viable-model-of-care-for-adults-with-intellectual-disabilities-in-india
#15
Desh Keerti Menon, M Thomas Kishore, T Sivakumar, Pallab K Maulik, Devvarta Kumar, Ram Lakhan, Ruma Banerjee
The longevity of people with intellectual disabilities is increasing in developing nations. However, developing nations lack a proper system of care for aging persons with intellectual disabilities. Until now the care has been provided by parents and relatives in the home environment in developing countries, but this scenario is also changing; therefore, there is a strong need to explore a plan of care for this population which is also feasible and replicable. The National Trust is an autonomous body of the Government of India which has developed a comprehensive plan of care for adults with intellectual disabilities...
September 2017: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/28812957/examining-gender-bias-in-the-feedback-shared-with-family-medicine-residents
#16
Chantal Loeppky, Oksana Babenko, Shelley Ross
OBJECTIVES: Competency-based education places increasing emphasis on formative feedback to learners as part of the assessment process. We wished to determine if gender bias was present in the feedback shared with post-graduate medical trainees (residents) in a two-year family medicine residency program at a Canadian university. METHODS: We performed secondary data analyses of documented feedback (FieldNotes) extracted from the Competency-Based Achievement System database...
August 16, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28812955/igg-cooperativity-is-there-allostery-implications-for-antibody-functions-and-therapeutic-antibody-development
#17
Danlin Yang, Rachel Kroe-Barrett, Sanjaya Singh, Christopher J Roberts, Thomas M Laue
A central dogma in immunology is that an antibody's in vivo functionality is mediated by two independent events: antigen binding by the variable (V) region, followed by effector activation by the constant (C) region. However, this view has recently been challenged by reports suggesting allostery exists between the two regions, triggered by conformational changes or configurational differences. The possibility of allosteric signals propagating through the IgG domains complicates our understanding of the antibody structure-function relationship, and challenges the current subclass selection process in therapeutic antibody design...
August 16, 2017: MAbs
https://www.readbyqxmd.com/read/28812944/binding-forces-between-a-novel-schiff-base-palladium-ii-complex-and-two-carrier-proteins-human-serum-albumi-and%C3%AE-lactoglobulin
#18
Somaye Shahraki, Ali Heydari
Ligand binding studies on carrier proteins are crucial in determining the pharmacological properties of drug candidates. Here, a new palladium(II) complex was synthesized and characterized. The in vitro binding studies of this complexwith two carrier proteins, human serum albumin (HSA) and β-lactoglobulin (βLG) was investigated by employing biophysical techniques as well as computational modeling. The experimental results showed thatthe Pd(II) complex interacted with two carrier proteins with moderate binding affinity (Kb ~̴ 0...
August 16, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28812942/acute-hypertensive-response-in-patients-with-intracerebral-hemorrhage-pathophysiology-and-treatment
#19
Adnan I Qureshi, Mushtaq H Qureshi
Acute hypertensive response is a common systemic response to occurrence of intracerebral hemorrhage which has gained unique prominence due to high prevalence and association with hematoma expansion and increased mortality. Presumably, the higher systemic blood pressure predisposes to continued intraparenchymal hemorrhage by transmission of higher pressure to the damaged small arteries and may interact with hemostatic and inflammatory pathways. Therefore, intensive reduction of systolic blood pressure has been evaluated in several clinical trials as a strategy to reduce hematoma expansion and subsequent death and disability...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28812930/increasing-colorectal-cancer-screening-at-an-urban-fqhc-using-ifobt-and-patient-navigation
#20
Richard L Martin, Madelaine Tully, Allison Kos, David Frazer, Amy Williamson, Amy Conlon, James J Enser, Noelle K LoConte
INTRODUCTION: Colorectal cancer is the second leading cause of cancer death in the United States. Black Americans suffer even higher incidence and death rates than the general population. Genetics and patient perceptions explain some of this difference, however, modifiable health care system factors such as lack of access to colon cancer screening also contribute. Partnering an academic health center with local community groups, we piloted a colorectal cancer screening program at a Federally Qualified Health Center (FQHC) serving predominately low socioeconomic status Black Americans...
September 2017: Health Promotion Practice
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