keyword
MENU ▼
Read by QxMD icon Read
search

systemic

keyword
https://www.readbyqxmd.com/read/29166762/a-portable-high-intensity-focused-ultrasound-system-for-the-pancreas-with-3d-electronic-steering-a-preclinical-study-in-a-swine-model
#1
Won Chang, Jae Young Lee, Jae Hwan Lee, Jae Seok Bae, Yeon Jin Cho, Kook Jin Kang, Keonho Son, Yul Ri Chung, Kyoung Bun Lee, Joon Koo Han
Purpose: The aim of this animal study was to evaluate the safety and feasibility of a portable, ultrasonography-guided, high-intensity focused ultrasound (USg-HIFU) system to treat the pancreas. Methods: Eight swine were included. Using a portable HIFU device (ALPIUS 900, Alpinion Medical Systems), ablations were performed on the pancreas in vivo. Different acoustic intensities were applied (1.7 kW/cm2 or 1.5 kW/cm2 , n=2 [group A for a pilot study]; 1.5 kW/ cm2 , n=3 [group B]; and 1...
October 13, 2017: Ultrasonography
https://www.readbyqxmd.com/read/29166758/clinical-significance-of-anti-dense-fine-speckled-70-antibody-in-patients-with-fibromyalgia
#2
Jisoo Jeong, Dong Hyun Kim, Gun Park, Suyeon Park, Hyun-Sook Kim
Background/Aims: Fibromyalgia (FM) is a common rheumatologic disease characterized by chronic widespread pain, along with various clinical manifestations including atypical autoimmune characteristics. Despite its high prevalence, there remain no approved laboratory tests to identify specific manifestations of FM, or to rule out FM from other rheumatic diseases. Anti-dense fine speckled 70 (anti-DFS70) antibodies were initially identified as a form of anti-nuclear antibodies in a patient with interstitial cystitis...
November 24, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29166752/immunotherapy-treatment-an-issue-for-metabolic-response
#3
Luca Tagliabue, Antonella Capozza, Claudio Maioli, Andrea Luciani, Anna M Ierardi, Gianpaolo Carrafiello
Since the beginning of second decade of this century, when it was introduced in many oncologic scenarios, immunotherapy has become an important tool in the management of a growing number of cancers. Engaging the host immune system in cancer therapy seems to be useful, improving not only progression free survival but also overall survival, until the achieving the goal that many advanced cancers, previously considered without effective treatment options, have now become successfully treatable. Moreover, considering the relatively recent introduction of these drugs in clinical scenarios and the continuous releasing of new drugs, large validated clinical experiences are lacking and many issues are today debated; by the way, the evaluation of the response to immune-therapy poses major concerns...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166742/-allogeneic-hematopoietic-stem-cell-transplantation-for-the-treatment-of-acute-myeloid-leukemia-with-primary-thrombocytosis-three-cases-report-and-literatures-review
#4
X P Zong, L Tang, J N Cen, S N Chen, A N Sun, D P Wu
Objective: To investigate the characteristics of the essential thrombocythemia (ET) cases transformed to the acute myeloid leukemia (AML) and the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of this disease. Methods: The clinical and laboratory characteristics of 3 ET cases before and after transformation and after allo-HSCT were retrospectively analyzed, meanwhile the related literatures were reviewed and discussed. Results: Case 1 was a male patient of 44 years old, whose PLT was 500×10(9)/L when firstly diagnosed ET...
October 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29166736/-prognosis-of-the-central-nervous-system-involvement-in-patients-with-hemophagocytic-lymphohistiocytosis
#5
F Y Wen, L Xiao, Y Xian, X H Wen, X M Guan, M L Liao, J Yu
Objective: To investigate the characteristics and prognostic factor of central nervous system (CNS) involvement in patients with hemophagocytic lymphohistiocytosis (HLH) . Methods: From January 2006 to October 2015, 152 patients with HLH, 88 patients had CNS involvement, their clinical data were collected, and survival was analyzed using the Kaplan-Meier life table method, univariate and multivariate Cox regression model analyses were applied to identify the risk factors of prognosis. Results: ①57.9% patients complicated with neurological symptoms, cerebrospinal fluid abnormalities were observed in 37...
October 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29166727/-analysis-on-the-trends-in-mortality-following-acute-myocardial-infarction-from-1999-to-2015-in-tianjin-of-china
#6
D Z Wang, H Zhang, Z L Xu, Y Zhang, G D Song, X D Xue, C Wang, G H Jiang
Objective: To explore the trends change in mortality following acute myocardial infarction (AMI) from 1999 to 2015 in Tianjin, China. Methods: AMI mortality data from 1999 to 2015 were obtained from Tianjin population based mortality surveillance system operated by the Tianjin Centers for Disease Control and Prevention (CDC), and population data of permanent residents were obtained from Tianjin Municipal Public Security Bureau. The trends change and affecting factors including gender, age, and geographic distribution on mortality following AMI were analyzed...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166720/-long-term-safety-and-efficacy-of-a-novel-abluminal-groove-filled-biodegradable-polymer-sirolimus-eluting-stent-for-the-treatment-of-coronary-de-novo-lesions
#7
C J Li, B Xu, C D Guan, R L Gao
Objective: To compare the long term safety and efficacy of the novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent(Firehawk stent) and permanent polymer coating everolimus eluting stent(Xience V stent) for the treatment of coronary de novo lesions. Methods: This prospective, multi-center, non-inferiority, randomized control trial(TARGETⅠ trial) was performed between August 2010 and April 2011, a total of 460 patients with primary, de novo, single vessel and single coronary lesion from 16 medical centers were enrolled...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166718/-value-of-two-left-atrium-and-pulmonary-vein-stereoscopic-imaging-reconstruction-methods-on-guiding-radiofrequency-ablation-for-atrial-fibrillation
#8
Y Tian, S Zhou, Y H Yin, Y X Zheng, R P Wang, X Q Liu, Z Q Liu, Q F Liu, W Liu, J Pang, Z Jiang, L H Tian, J Huang, L Yang
Objective: To compare the value of two 3D imaging reconstruction methods for left atria and pulmonary vein on guiding the catheter ablation for atrial fibrillation (AF). Methods: From January 2014 to January 2017, a total of 100 drug refractory paroxysmal AF patients were divided into left atria direct angiography group (n=50), and indirect angiography group (n=50). 3D CARTO system was applied for mapping and guiding the ablation procedure. Patients assigned to direct angiography group were treated as follows: intraoperative puncture of atrial septum, inject contrast agent directly into the left atrium, conduct left atrial and pulmonary venous rotation angiography, reconstruct three-dimensional image, integrate the image into real-time X-ray system to facilitate circumferential pulmonary vein isolation...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166717/-left-atrial-appendage-volume-is-a-valuable-predictor-of-atrial-fibrillation-recurrence-after-radiofrequency-catheter-ablation
#9
G A Zheng, C Y Lin, L Weng, J D Chen
Objective: To investigate the association between the left atrial appendage (LAA) volume and atrial fibrillation (AF) recurrence after radiofrequency catheter ablation. Methods: We prospectively enrolled sixty-two patients with AF (40 cases with paroxysmal AF, 22 cases with persistent AF) who successfully underwent a first AF catheter ablation and had performed contrast-enhanced cardiac computed tomography (CT) prior to the procedure to measure LAA volumes in our hospital from January 2012 to August 2015. Circumferential pulmonary vein isolation was performed under the guidance of three-dimension mapping system (CARTO system)...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166709/-effects-of-dexmedetomidine-on-myocardium-of-rats-with-severe-burn-at-early-stage
#10
D Wang, P L Yang, X Zhang, Y Liu
Objective: To investigate the effects of dexmedetomidine on myocardium of rats at early stage after severe burn. Methods: Twenty specific pathogen free male SD rats were immersed in 90 ℃ hot water for 20 s, causing 30% total body surface area (TBSA) full-thickness scald (hereafter referred to as burn) on the back. And then they were divided into burn resuscitation group (BR) and burn resuscitation+ dexmedetomidine group (BRD) according to the random number table, with 10 rats in each group. Sodium lactate Ringer's solution (2 mL·kg(-1)·%TBSA(-1)) were intraperitoneally injected into rats of both groups after burn...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29166705/comprehensive-analysis-of-nine-monoamines-and-metabolites-in-small-amounts-of-peripheral-murine-c57bl-6j-tissues
#11
Joachim Nagler, Sonja C Schriever, Meri De Angelis, Paul T Pfluger, Karl-Werner Schramm
Monoamines, acting as hormones and neurotransmitters, play a critical role in multiple physiological processes ranging from cognitive function and mood to sympathetic nervous system activity, fight-or-flight response, or glucose homeostasis. In addition to brain and blood, monoamines are abundant in several tissues, and dysfunction in their synthesis or signaling is associated with various pathological conditions. It was our goal to develop a method to detect these compounds in peripheral murine tissues. In this study, we employed a high performance liquid chromatography method using electrochemical detection that allows not only detecting the catecholamines but a detailed analysis of nine monoamines and metabolites in murine tissues...
November 22, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29166690/-facial-emotion-recognition-theory-of-mind-and-empathy-in-multiple-sclerosis
#12
Samar S Ayache, Moussa A Chalah, Tania Kuempfel, Frank Padberg, Jean-Pascal Lefaucheur, Ulrich Palm
Multiple sclerosis (MS), a chronic progressive inflammatory disease of the central nervous system, causes frequent disability, mood disorders, fatigue, and cognitive dysfunction. As a part of the last, social cognition is frequently disturbed in MS patients. It comprises empathy and social perception of emotions from facial, bodily and vocal cues. Social cognitive deficits worsen affect decoding, interpersonal relationship, and quality of life. Despite the impact of these deficits on global functioning, only a small number of studies have investigated its correlations and overlaps with MS symptoms...
November 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29166687/-how-probable-is-it-that-seniors-using-an-e-bike-will-have-an-accident-a-new-health-care-topic-also-for-consulting-doctors
#13
Raphael Weiss, Christian Juhra, Britta Wieskötter, Udo Weiss, Susanne Jung, Michael Raschke
Background In Germany there are more than 70 million bicycles. Because of technical progress, over 200,000 electro-assisted bikes were sold in Germany in 2010 alone. In 2013, the number increased to 410,000. Currently more than 1.6 million electric bicycles are used here. One of the largest user groups are seniors. Accident researchers fear an increased risk of accidents/injuries. Methods For one year, all cycling accidents involving electric bicycles and senior citizens were collected and analysed in 23 hospitals of the TraumaNetwork NorthWest and by the local police authorities...
November 22, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29166685/-evaluation-of-inpatient-conservative-management-of-acute-subacute-and-chronic-back-pain
#14
Ingo Haase, Kilian Haase, Bernd Kladny
Background Backache is very common in the German population. It is a common reason for people to seek medical advice and specific back pain programs have been developed. The intention of this study is to evaluate the short and long term effects of conservative management of back pain in a German general hospital. Outcomes of interest were pain intensity, interference in daily functions, physical functioning and health related quality of life. Patients and Methods We examined 1010 patients with acute, subacute and chronic back pain, admitted to inpatient nonsurgical interventional therapy in a German hospital between July 2013 and July 2015...
November 22, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29166684/-implantation-of-a-modular-distal-femoral-replacement-with-compressive-osseointegration-as-a-salvage-procedure-in-a-complex-femoral-posttraumatic-setting
#15
Anna Janine Schreiner, Peter Marten de Zwart, Christian Arnscheidt, Ulrich Stöckle, Björn Gunnar Ochs
Background Large bone defects and losses play a crucial role in both tumour surgery and in complex primary and revision total knee replacement. The established options of cemented or uncemented long intramedullary stems are limited by large bone defects and are at risk from relatively high exposure to aseptic loosening. There is no general valid agreement on implant fixation of the distal femur. A further option is the cementless fixation method with compressive osseointegration, based on the so-called Wolff law of bone remodelling...
November 22, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29166667/flotillin-scaffold-activity-contributes-to-type-vii-secretion-system-assembly-in-staphylococcus-aureus
#16
Benjamin Mielich-Süss, Rabea M Wagner, Nicole Mietrach, Tobias Hertlein, Gabriella Marincola, Knut Ohlsen, Sebastian Geibel, Daniel Lopez
Scaffold proteins are ubiquitous chaperones that promote efficient interactions between partners of multi-enzymatic protein complexes; although they are well studied in eukaryotes, their role in prokaryotic systems is poorly understood. Bacterial membranes have functional membrane microdomains (FMM), a structure homologous to eukaryotic lipid rafts. Similar to their eukaryotic counterparts, bacterial FMM harbor a scaffold protein termed flotillin that is thought to promote interactions between proteins spatially confined to the FMM...
November 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29166663/a-general-model-for-predicting-the-binding-affinity-of-reversibly-and-irreversibly-dimerized-ligands
#17
Kenneth W Foreman
Empirical data has shown that bivalent inhibitors can bind a given target protein significantly better than their monomeric counterparts. However, predicting the corresponding theoretical fold improvements has been challenging. The current work builds off the reacted-site probability approach to provide a straightforward baseline reference model for predicting fold-improvements in effective affinity of dimerized ligands over their monomeric counterparts. For the more familiar irreversibly linked bivalents, the model predicts a weak dependence on tether length and a scaling of the effective affinity with the 3/2 power of the monomer's affinity...
2017: PloS One
https://www.readbyqxmd.com/read/29166662/detection-of-hbsag-mutants-in-the-blood-donor-population-of-pakistan
#18
Ahmad Farooq, Usman Waheed, Hasan Abbas Zaheer, Fahad Aldakheel, Shatha Alduraywish, Muhammad Arshad
BACKGROUND: Infection with the Hepatitis B virus (HBV) continues to be one of the leading healthcare issues in Pakistan, affecting over 6 million people. The existence of HBsAg mutants is well documented in many countries. In Pakistan, HBV screening in the majority of the blood banks is performed by Rapid Detection Devices or ELISA tests. These tests are designed to detect HBsAg, but may not detect the mutant HBsAg. Failure to detect the HBsAg mutant may result in the transmission of HBV infection from donor to recipient...
2017: PloS One
https://www.readbyqxmd.com/read/29166656/fragmentation-modes-and-the-evolution-of-life-cycles
#19
Yuriy Pichugin, Jorge Peña, Paul B Rainey, Arne Traulsen
Reproduction is a defining feature of living systems. To reproduce, aggregates of biological units (e.g., multicellular organisms or colonial bacteria) must fragment into smaller parts. Fragmentation modes in nature range from binary fission in bacteria to collective-level fragmentation and the production of unicellular propagules in multicellular organisms. Despite this apparent ubiquity, the adaptive significance of fragmentation modes has received little attention. Here, we develop a model in which groups arise from the division of single cells that do not separate but stay together until the moment of group fragmentation...
November 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29166651/stiffness-analysis-of-3d-spheroids-using-microtweezers
#20
Devina Jaiswal, Norah Cowley, Zichao Bian, Guoan Zheng, Kevin P Claffey, Kazunori Hoshino
We describe a novel mechanical characterization method that has directly measured the stiffness of cancer spheroids for the first time to our knowledge. Stiffness is known to be a key parameter that characterizes cancerous and normal cells. Atomic force microscopy or optical tweezers have been typically used for characterization of single cells with the measurable forces ranging from sub pN to a few hundred nN, which are not suitable for measurement of larger 3D cellular structures such as spheroids, whose mechanical characteristics have not been fully studied...
2017: PloS One
keyword
keyword
28866
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"