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Fungal rhinosinusitis

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https://www.readbyqxmd.com/read/28505035/invasive-fungal-sinusitis-treatment-of-the-orbit
#1
Evan Kalin-Hajdu, Kristin E Hirabayashi, M Reza Vagefi, Robert C Kersten
PURPOSE OF REVIEW: To summarize diagnostic techniques for invasive fungal rhinosinusitis and provide a review of treatment options once disease has spread to the orbit. RECENT FINDINGS: Improved imaging criteria, polymerase chain reaction and other serologic tests show promise in advancing our ability to accurately diagnose invasive fungal disease. Currently, there exists three treatment options for infected orbital tissue: exenteration, conservative debridement and transcutaneous retrobulbar injection of amphotericin B...
May 12, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28501959/contralateral-sinus-involvement-of-surgically-treated-unilateral-allergic-fungal-rhinosinusitis
#2
Abdulaziz AlQahtani, N Alshaikh, A Alzarei, A Musleh, A Alamri, A Alqahtani, F Alfawwaz, F Alshammari, M Aloulah, O Marglani, S Alsaleh, T Alandejani, H Mokarbesh
Recurrence of allergic fungal rhinosinusitis (AFRS) is well recognized. However, there is scarcity in the literature describing involvement of the non-diseased sinuses. We aimed to evaluate the recurrence forms of unilateral AFRS as well as to study the possible predictor factors of developing the disease in the contralateral side. Patients with exclusive unilateral AFRS from (2010 to 2015) were enrolled in multi-institutional case-control study. All patients were evaluated after endoscopic sinus surgery for recurrence...
May 13, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28497678/eosinophil-fungal-rhinosinusitis-caused-by-fusarium-infection-secondary-to-odontogenic-maxillary-sinus-disease-when-collaboration-between-otolaryngologist-and-allergologist-leads-to-the-correct-diagnosis-and-therapy
#3
P Gamba, C Lombardi
Rhinitis and sinusitis usually coexist and are concurrent in most individuals; thus, the correct terminology is now "rhinosinusitis". On the basis of numerous causative factors, often co-existing in the same patient, the diagnosis of rhinosinusitis is also made by a wide variety of practitioners (allergologists, otolaryngologists, pulmonologists, primary care physicians, paediatricians, and many others). Approximately 5-15% of the population suffers from chronic rhinosinusitis, and in 10-12% of them, it is of dental origin...
May 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28495416/invasive-fungal-rhinosinusitis-presenting-as-bell-s-palsy-in-a-kidney-and-liver-transplant-recipient
#4
Maggie Ming Yee Mok, Benjamin Xin Hao Fang, Bo Ying Choy, Tak Mao Chan
No abstract text is available yet for this article.
May 8, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28482010/study-toward-resolving-the-controversy-over-the-definition-of-allergic-fungal-rhinosinusitis
#5
Aleksandra Barac, Goran Stevanovic, Marina Pekmezovic, Zoran Rakocevic, Rajica Stosovic, Boban Erovic, Vesna Tomic Spiric
Dysbiosis of the microbiome on the airway mucosa leads to the development of chronic inflammatory and allergic disorders. The aim of this study was to consider the potential diagnostic criteria for allergic fungal rhinosinusitis (AFRS) and nonallergic fungal rhinosinusitis (FRS), and the role of fungal presence in an environment for the development of AFRS. In this study, 136 patients were divided into two groups: patients with positive specific immunoglobulin E (sIgE) and fungal finding (AFRS group), and patients with negative sIgE and positive fungal finding (FRS group)...
May 6, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28452707/complete-surgical-resection-and-short-term-survival-in-acute-invasive-fungal-rhinosinusitis
#6
Christopher R Roxbury, David F Smith, Thomas S Higgins, Stella E Lee, Gary L Gallia, Masaru Ishii, Andrew P Lane, Douglas D Reh
BACKGROUND: Acute invasive fungal rhinosinusitis (AIFR) is a fulminant fungal infection seen in patients who are immunocompromised. Due to its rarity, there is little evidence regarding the appropriate antifungal treatment regimen, especially the degree of surgical intervention. OBJECTIVE: To assess factors that impact short-term survival in AIFR as defined by survival to hospital discharge and to develop a staging system to predict survival and complete surgical resection...
March 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28438285/fungal-rhinosinusitis-a-radiological-review-with-intraoperative-correlation
#7
REVIEW
Elaine Ni Mhurchu, Javier Ospina, Arif S Janjua, Jason R Shewchuk, Alexandra T Vertinsky
The interaction between fungi and the sinonasal tract results in a range of clinical presentations with a broad spectrum of clinical severity. The most commonly accepted classification system divides fungal rhinosinusitis into invasive and noninvasive subtypes based on histopathological evidence of tissue invasion by fungi. Invasive fungal rhinosinusitis is subdivided into acute invasive and chronic invasive categories. The chronic invasive category includes a subcategory of chronic granulomatous disease. Noninvasive fungal disease includes localized fungal colonization, fungal ball, and allergic fungal rhinosinusitis...
May 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28434016/chronic-rhinosinusitis-and-mood-disturbance
#8
S E Erskine, C Hopkins, A Clark, S Anari, A Robertson, S Sunkaraneni, J A Wilson, J Beezhold, C M Philpott
BACKGROUND: This study is part of the Chronic Rhinosinusitis Epidemiology Study (CRES). The overarching aim is to determine factors that influence the onset and severity of chronic rhinosinusitis (CRS). The aim of this analysis is to determine whether those with CRS are more likely to report psychiatric morbidity and in particular mood disturbance compared with healthy controls. METHODS: CRES consists of a study-specific questionnaire regarding demographic and socioeconomic factors and past medical history as well as a nasal symptom score (SNOT-22) and SF-36 (QoL - quality of life tool)...
April 23, 2017: Rhinology
https://www.readbyqxmd.com/read/28379569/one-health-pathogens-in-the-aspergillus-viridinutans-complex
#9
Jessica J Talbot, Vanessa R Barrs
Cryptic species in Aspergillus section Fumigati are increasingly recognised as pathogens in humans and animals. The A. viridinutans complex (AVC) has recently expanded to comprise 10 species, of which six are known to be pathogenic, including A. udagawae, A. felis, A. pseudofelis, A. parafelis, A. pseudoviridinutans, and A. wyomingensis. They cause locally invasive and disseminated invasive disease syndromes, including chronic pulmonary aspergillosis and invasive aspergillosis in humans, invasive fungal rhinosinusitis in cats, and disseminated invasive aspergillosis in dogs...
March 31, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28376637/correlation-of-symptoms-clinical-signs-and-biomarkers-of-inflammation-in-postsurgical-chronic-rhinosinusitis
#10
Samuel D Racette, Rohan C Wijewickrama, Vijayvel Jayaprakash, David A Sherris, Carlos Santos, Hirohito Kita, Frank E O'Donnell, Jens U Ponikau
OBJECTIVE: The study aimed to evaluate symptoms described by patients with chronic rhinosinusitis with polypoid changes/nasal polyps and their correlation with computed tomography (CT), nasal endoscopy, and intranasal biomarkers. STUDY DESIGN: Prospective multicenter study symptom data from postsurgical adult chronic rhinosinusitis study participants with recurrent disease refractory to medical therapy were analyzed in comparison with objective data. METHODS: Using logistic regression analysis, participant-rated 16-question surveys from 258 participants were assessed for correlation with nasal endoscopy scores, CT percentage of sinus occlusion, and intranasal biomarkers of fungal antigens (Alternaria and Aspergillus), eosinophilic inflammation (eosinophil-derived neurotoxin [EDN] and major basic protein [MBP]), and inflammatory cytokines (interleukins 5 and 13)...
June 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28251318/isolated-sphenoid-sinus-fungus-ball-a-retrospective-study-conducted-at-a-tertiary-care-referral-center-in-korea
#11
Hyun-Sil Lim, Young Hoon Yoon, Jun Xu, Yong Min Kim, Ki-Sang Rha
Fungus ball (FB) is the most common form of extramucosal fungal rhinosinusitis involving one or more paranasal sinuses. The sphenoid sinus is an uncommon site of this disease. Here, we present our 20-year experience of managing isolated sphenoid sinus FB (SSFB). We retrospectively reviewed a series of 47 cases of isolated SSFB encountered between 1996 and 2015 with reference to the chronological incidence, demographics, clinical features, radiological findings, treatment modalities, and outcome. Recently, the number of patients with isolated SSFB has increased markedly...
June 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28199369/nasal-nitric-oxide-in-unilateral-sinus-disease
#12
Chia-Hsiang Fu, Hsiao-Jung Tseng, Chi-Che Huang, Po-Hung Chang, Yi-Wei Chen, Ta-Jen Lee
Unilateral sinus disease (USD) can sometimes be difficult to accurately diagnose before surgery. The application of nasal nitric oxide (nNO) for USD diagnosis and its surgical outcome in USD has not been reported in the literature. We prospectively enrolled sixty-six USD patients who underwent endoscopic sinus surgery for fungal rhinosinusitis (n = 19), chronic rhinosinusitis (CRS) without nasal polyps (n = 13), CRS with nasal polyps (n = 12) and sinonasal mass lesions (n = 22). nNO levels were measured preoperatively and at three and six months postoperatively...
2017: PloS One
https://www.readbyqxmd.com/read/28185668/effect-of-nebulized-budesonide-on-decreasing-the-recurrence-of-allergic-fungal-rhinosinusitis
#13
Qi Dai, Chen Duan, Quan Liu, Hongmeng Yu
OBJECTIVE: The aim of this study was to evaluate the clinical efficacy and the effects on decreasing the recurrence of AFRS (allergic fungal rhinosinusitis) of a budesonide inhalation suspension delivered via transnasal nebulization to patients following endoscopic sinus surgery. SUBJECTS AND METHODS: Thirty-five patients were recruited into this study. Final diagnoses were reached using Bent and Kuhn's criteria. The eligible patients were randomly divided into two groups: the budesonide transnasal nebulization group (group A) and the topical nasal steroids group (group B)...
February 1, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28182334/utility-of-intraoperative-frozen-sections-in-surgical-decision-making-for-acute-invasive-fungal-rhinosinusitis
#14
Peter Papagiannopoulos, Diana Murro Lin, Samer Al-Khudari, Kumar Rajan, Swathi Reddy, Paulo Gattuso, Bobby Tajudeen, Pete S Batra
BACKGROUND: Acute invasive fungal rhinosinusitis (AIFRS) represents a fulminant, potentially fatal, disease process in immunocompromised patients. The diagnosis often rests on high index of clinical suspicion, with relative paucity of data on the diagnostic and therapeutic implications of intraoperative frozen sections. METHODS: Retrospective review was performed for 18 cases undergoing endoscopic sinus surgery for AIFRS. Reliability of intraoperative frozen section diagnosis was evaluated for all patients using final pathology as the gold standard...
May 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28100314/matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-for-rapid-identification-of-fungal-rhinosinusitis-pathogens
#15
Yanfei Huang, Jinglin Wang, Mingxin Zhang, Min Zhu, Mei Wang, Yufeng Sun, Haitong Gu, Jingjing Cao, Xue Li, Shaoya Zhang, Xinxin Lu
PURPOSE: Filamentous fungi are among the most important pathogens, causing fungal rhinosinusitis (FRS). Current laboratory diagnosis of FRS pathogens mainly relies on phenotypic identification by culture and microscopic examination, which is time consuming and expertise dependent. Although matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) MS has been employed to identify various fungi, its efficacy in the identification of FRS fungi is less clear. METHODOLOGY: A total of 153 FRS isolates obtained from patients were analysed at the Clinical Laboratory at the Beijing Tongren Hospital affiliated to the Capital Medical University, between January 2014 and December 2015...
March 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28031066/expression-of-maspin-in-invasive-fungal-rhinosinusitis
#16
Y D Huang, H W Yu, S W Xia, Z H Kang, Y S He, D Y Han
OBJECTIVE: This study aimed to test the expression of maspin in invasive fungal rhinosinusitis and explore its value in diagnosing invasive fungal rhinosinusitis. METHODS: Forty-two fungal rhinosinusitis cases (12 invasive and 30 non-invasive) were selected as the experimental group, and 30 chronic rhinosinusitis cases comprised the control group. Maspin expression was assessed in nasal mucous membrane specimens by immunohistochemical staining. RESULTS: Compared with the control group, maspin expression was down-regulated in the fungal rhinosinusitis group (p < 0...
February 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28027285/acute-rhinosinusitis-in-immunosuppressed-children-diagnostic-and-therapeutic-management
#17
Amit Ritter, Salvador Fischer, Eitan Yaniv, Tuvia Hadar, Ethan Soudry, Daniel Shai, Dror Gilony, Gideon Bachar
BACKGROUND: Immunosuppressive therapy places pediatric patients at risk of developing life-threatening sinonasal infections. Diagnosis and treatment are challenging owing to nonspecific signs and symptoms. The aim of this study was to present our department's experience with the surgical management of acute rhinosinusitis in immunosuppressed children. METHODS: The records of all children with a hematologic or oncologic disease who underwent endoscopic sinus surgery (ESS) for acute rhinosinusitis from January 2005 to May 2014 were reviewed...
April 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27918884/acute-invasive-fungal-rhinosinusitis-presentation-of-19-cases-review-of-the-literature-and-a-new-classification-system
#18
REVIEW
Onur Ergun, Emel Tahir, Oguz Kuscu, Burce Ozgen, Taner Yilmaz
PURPOSE: The aim of this study was to determine the correlation between acute invasive fungal rhinosinusitis (AIFRS) and underlying diseases, micro-organisms, presenting symptoms, extent of disease, radiologic findings, and outcomes and propose a new classification system. MATERIALS AND METHODS: The data of 19 AIFRS cases were analyzed retrospectively. Magnetic resonance imaging and computed tomography were performed in all patients preoperatively. All patients underwent at least 1 surgical debridement...
April 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27903594/chronic-rhinosinusitis-and-the-evolving-understanding-of-microbial-ecology-in-chronic-inflammatory-mucosal-disease
#19
REVIEW
Michael Hoggard, Brett Wagner Mackenzie, Ravi Jain, Michael W Taylor, Kristi Biswas, Richard G Douglas
Chronic rhinosinusitis (CRS) encompasses a heterogeneous group of debilitating chronic inflammatory sinonasal diseases. Despite considerable research, the etiology of CRS remains poorly understood, and debate on potential roles of microbial communities is unresolved. Modern culture-independent (molecular) techniques have vastly improved our understanding of the microbiology of the human body. Recent studies that better capture the full complexity of the microbial communities associated with CRS reintroduce the possible importance of the microbiota either as a direct driver of disease or as being potentially involved in its exacerbation...
January 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/27888473/nasal-mucosa-healing-after-endoscopic-sinus-surgery-in-chronic-rhinosinusitis-of-elderly-patients-role-of-topic-alpha-tocopherol-acetate
#20
RANDOMIZED CONTROLLED TRIAL
Domenico Testa, Giuseppina Marcuccio, Giorgio Panin, Andrea Bianco, Domenico Tafuri, Francesco Zappoli Thyrion, Michele Nunziata, Pasquale Piombino, Germano Guerra, Gaetano Motta
BACKGROUND: Chronic rhinosinusitis (CRS) in European country ranges in elderly patients from 4.5 to 12% of population and has a significant effect on quality of life. In these patients, rhinosinusitis is linked to immune functions changes with age and to mucosal paraphysiological alterations such as crusting formations with atrophic epithelium, variations of nasal airflow and modifications of the mucociliary clearance. Failure of medical treatments leads to surgery in patients with persistent symptoms and radiographic signs of CRS...
February 2017: Aging Clinical and Experimental Research
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