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Oropharyngeal squamous cell carcinoma

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https://www.readbyqxmd.com/read/28654785/global-incidence-of-oral-and-oropharynx-cancer-in-patients-younger-than-45-years-versus-older-patients-a%C3%A2-systematic-review
#1
REVIEW
Aisha A Hussein, Marco N Helder, Jan G de Visscher, C René Leemans, Boudewijn J Braakhuis, Henrica C W de Vet, Tymour Forouzanfar
Head and neck squamous cell carcinoma (HNSCC) is typically regarded as a disease of elderly people. However, increasing numbers of patients worldwide with HNSCC at younger age (defined as <45 years old) have been reported in recent years. To assess geographical variations and trends worldwide in incidence of oral and oropharyngeal cancer in young patients, a systematic review was conducted in PubMed and Google scholar databases from 1975 to June 2016. Seventy-eight studies were selected for further study...
June 24, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28651338/evaluation-of-the-impact-of-tumor-hpv-status-on-outcome-in-patients-with-locally-advanced-unresectable-head-and-neck-squamous-cell-carcinoma-hnscc-receiving-cisplatin-5-fluorouracil-with-or-without-docetaxel-a-subset-analysis-of-eortc-24971-study
#2
A Psyrri, C Fortpied, G Koutsodontis, M Avgeris, C Kroupis, N Goutas, J Menis, L Herman, L Giurgea, E Remenar, M Degardin, I S Pateras, J A Langendijk, C van Herpen, A Awada, J R Germà-Lluch, H R Kienzer, L Licitra, J B Vermorken
Background: EORTC 24971 was a phase III trial demonstrating superiority of induction regimen TPF over PF, in terms of progression-free (PFS) and overall survival (OS) in locoregionally advanced unresectable HNSCC. We conducted a retrospective analysis of prospectively collected data aiming to evaluate whether only HPV(-) patients (pts) benefit from adding docetaxel to PF, in which case de-intensifying induction treatment in HPV(+) pts could be considered. Methods: Pre-therapy tumor biopsies (blocks or slides) were assessed for high-risk HPV by p16 immunohistochemistry, PCR and qPCR...
June 23, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28650113/distant-metastases-in-head-and-neck-cancer
#3
Fréderic Duprez, Dieter Berwouts, Wilfried De Neve, Katrien Bonte, Tom Boterberg, Philippe Deron, Wouter Huvenne, Sylvie Rottey, Marc Mareel
BACKGROUND: Most trials in head and neck cancer emphasize locoregional control, as this is the main pattern of therapy failure. However, up to 15% of patients develop distant metastases. The purpose of this study was to present the investigated factors associated with distant metastasis in a single-center patient cohort. METHODS: A retrospective analysis of a single-center patient cohort over an 18-year period has been performed. We report on prevalence and incidence of distant metastasis, timing in relation to locoregional failure, Kaplan-Meier analysis for actuarial distant control rates, and univariate analysis taking into account histological, etiologic, surgical, site-dependent, stage-dependent characteristics, modality of primary therapy, and locoregional control...
June 26, 2017: Head & Neck
https://www.readbyqxmd.com/read/28642609/microbial-signatures-associated-with-oropharyngeal-and-oral-squamous-cell-carcinomas
#4
Sagarika Banerjee, Tian Tian, Zhi Wei, Kristen N Peck, Natalie Shih, Ara A Chalian, Bert W O'Malley, Gregory S Weinstein, Michael D Feldman, James Alwine, Erle S Robertson
The microbiome is fundamentally one of the most unique organs in the human body. Dysbiosis can result in critical inflammatory responses and result in pathogenesis contributing to neoplastic events. We used a pan-pathogen array technology (PathoChip) coupled with next-generation sequencing to establish microbial signatures unique to human oral and oropharyngeal squamous cell carcinomas (OCSCC/OPSCC). Signatures for DNA and RNA viruses including oncogenic viruses, gram positive and negative bacteria, fungi and parasites were detected...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28641957/kindler-syndrome-complicated-by-invasive-squamous-cell-carcinoma-of-the-palate
#5
H Souldi, M Y Bajja, M Mahtar
INTRODUCTION: Kindler syndrome is a very rare, autosomal recessive genodermatosis characterized by skin fragility and photosensitivity in infancy with progressive poikiloderma. CASE REPORT: We report the case of a young woman with a history of Kindler syndrome predominantly characterized by extensive involvement of the oropharyngeal mucosa. The patient presented with an ulcerative lesion of the palate. Computed tomography and biopsy concluded on unresectable invasive squamous cell carcinoma of the hard palate...
June 19, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28640546/treatment-at-high-volume-facilities-and-academic-centers-is-independently-associated-with-improved-survival-in-patients-with-locally-advanced-head-and-neck-cancer
#6
John M David, Allen S Ho, Michael Luu, Emi J Yoshida, Sungjin Kim, Alain C Mita, Kevin S Scher, Stephen L Shiao, Mourad Tighiouart, Zachary S Zumsteg
BACKGROUND: The treatment of head and neck cancers is complex and associated with significant morbidity, requiring multidisciplinary care and physician expertise. Thus, facility characteristics, such as clinical volume and academic status, may influence outcomes. METHODS: The current study included 46,567 patients taken from the National Cancer Data Base who were diagnosed with locally advanced invasive squamous cell carcinomas of the oropharynx, larynx, and hypopharynx and were undergoing definitive radiotherapy...
June 22, 2017: Cancer
https://www.readbyqxmd.com/read/28639061/oral-and-oropharyngeal-papillomas-are-not-associated-with-high-risk-human-papillomavirus-infection
#7
Miroslaw Snietura, Roman Lamch, Agnieszka Kopec, Dariusz Waniczek, Wirginia Likus, Dariusz Lange, Jaroslaw Markowski
The role of different types of human papillomavirus (HPV) in the development of oral and oropharyngeal papillomas remains unclear. High-risk HPV (HR-HPV) was shown to be involved in the pathogenesis of significant proportion of squamous cell carcinomas of the oropharynx. In this study, we hypothesized that in some oropharyngeal papillomas, low-risk HPV (LR-HPV) and HR-HPV infection could co-exist, similar to what is observed in genital warts, and thus contribute to the elevated risk of malignancy. To test this hypothesis, we used real-time PCR to assess the presence of HPV DNA of 16 types (2 LR-HPV and 14 HR-HPV), in 75 formalin-fixed and paraffin-embedded histopathological samples of oral and oropharyngeal papillomas and in 57 squamous cell carcinomas from the same regions...
June 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28638410/low-survival-rates-of-oral-and-oropharyngeal-squamous-cell-carcinoma
#8
Anna Carolina Omena Vasconcellos Le Campion, Camila Maria Beder Ribeiro, Ronir Raggio Luiz, Francisco Feliciano da Silva Júnior, Herbert Charles Silva Barros, Karine de Cássia Batista Dos Santos, Stefania Jeronimo Ferreira, Lucio Souza Gonçalves, Sonia Maria Soares Ferreira
AIM: To assess the epidemiological and clinical factors that influence the prognosis of oral and oropharyngeal squamous cell carcinoma (SCC). METHODS: One hundred and twenty-one cases of oral and oropharyngeal SCC were selected. The survival curves for each variable were estimated using the Kaplan-Meier method. The Cox regression model was applied to assess the effect of the variables on survival. RESULTS: Cancers at an advanced stage were observed in 103 patients (85...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28633362/human-papillomavirus-related-oropharyngeal-cancer
#9
M Taberna, M Mena, M A Pavón, L Alemany, M L Gillison, R Mesía
High-risk (HR) human papillomavirus (HPV) is now recognised as the principal cause of the increasing incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) in some parts of the world.The primary risk factor for developing HPV-related OPSCC is oral HPV-infection and the majority of oral HPV-infections are acquired by oral sex. Progression into a OPSCC includes persistent infection with evasion of immune response in the microenvironment, the activation of viral early genes (E6, E7) in basal epithelial cells, the deregulation of cell cycle and the accumulation of chromosomal instability...
June 15, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28633075/elective-unilateral-nodal-irradiation-in-head-and-neck-squamous-cell-carcinoma-a-paradigm-shift
#10
A Al-Mamgani, M Verheij, M W M van den Brekel
There is a long-standing convention to irradiate the great majority of head and neck squamous cell carcinoma (HNSCC) electively to both sides of the neck, to reduce the theoretically increased risk of contralateral regional failure (cRF). With the currently available diagnostic imaging techniques this treatment paradigm means, in our opinion, an overtreatment in considerable proportion of these patients. From all the published studies (n = 11, with 1116 patients treated in total), the incidence of cRF in patients with oropharyngeal cancer treated to one side of the neck is 2...
June 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28632936/peritumoral-cuffing-by-t-cell-tumor-infiltrating-lymphocytes-distinguishes-hpv-related-oropharyngeal-squamous-cell-carcinoma-from-oral-cavity-squamous-cell-carcinoma
#11
Kate Poropatich, David Hernandez, Joel Fontanarosa, Koshonna Brown, Gayle Woloschak, Ajit Paintal, Kirtee Raparia, Sandeep Samant
BACKGROUND: It is unclear why human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) has improved clinical behavior compared to HPV-negative HNSCC. We sought to better characterize the immune microenvironment of tongue cancers by examining the CD3 and CD8 TIL pattern in HPV-positive and -negative tumors. METHODS: Histologic sections from 40 oral tongue and oropharyngeal cases were analyzed (n= 21 HPV DNA-positive, n= 19 HPV DNA-negative)...
June 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28627802/the-length-of-patient-and-primary-care-time-interval-in-the-pathways-to-treatment-in-symptomatic-oral-cancer-a-quantitative-systematic-review
#12
P Varela-Centelles, J Seoane, J L Lopez-Cedrun, J Fernandez-Sanroman, J M García-Martin, B Takkouche, P Alvarez-Novoa, J M Seoane-Romero
BACKGROUND: Only a 5% improvement in overall survival to oral cancer has been achieved in the last 20 years. Almost half of all oral carcinomas are diagnosed at advanced stages essentially due to delay in the diagnosis. Objective of the review: to examine the relative length of the patient and primary care intervals in symptomatic oral cancer. TYPE OF REVIEW: Quantitative systematic review. SEARCH STRATEGY: ((oral cancer OR oral squamous cell carcinoma OR oropharyngeal cancer) AND (time interval OR diagnostic delay))...
June 19, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28627689/expression-of-cell-cycle-related-proteins-in-oropharyngeal-squamous-cell-carcinoma-based-on-human-papilloma-virus-status
#13
Koudai Tsuchida, Tamotsu Sugai, Noriyuki Uesugi, Kazuyuki Ishida, Kazuto Matsuura, Ikuro Sato, Kiyoto Shiga, Hiroaki Sato
The molecular association between human papilloma virus (HPV) and cell cycle-related (CCR) proteins is not fully understood in oropharyngeal squamous cell carcinoma (OPSCC). Herein, we examined the expression levels of CCRs in OPSCCs based on HPV status. In situ hybridization (ISH)- and polymerase chain reaction (PCR)-based assays were used to detect HPV status in 98 OPSCCs, and CCRs were detected by immunostaining. Of 98 tumors, 47 had HPV-positive tumors by either ISH- or PCR-based assays. Concordance analysis between ISH- and PCR-based tests showed a good agreement in OPSCC...
June 14, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28622885/the-impact-of-prophylactic-external-carotid-artery-ligation-on-postoperative-bleeding-after-transoral-robotic-surgery-tors-for-oropharyngeal-squamous-cell-carcinoma
#14
John Gleysteen, Scott Troob, Tyler Light, Daniel Brickman, Daniel Clayburgh, Peter Andersen, Neil Gross
BACKGROUND: Transoral robotic-assisted surgery (TORS) is increasingly utilized in the treatment of oropharyngeal squamous cell carcinoma (OPSCC). Postoperative bleeding is a significant and potentially fatal complication of TORS. Prophylactic ligation of ipsilateral external carotid artery (ECA) branches is a recognized strategy to reduce postoperative bleeding risk. We examined the incidence and sequelae of postoperative oropharyngeal bleeding with and without routine ECA ligation. METHODS: OPSCC patients treated with TORS between 2010 and 2015 with minimum 30days follow up were included...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28621317/p16-immunohistochemistry-in-oropharyngeal-squamous-cell-carcinoma-a-comparison-of-antibody-clones-using-patient-outcomes-and-high-risk-human-papillomavirus-rna-status
#15
Jeremy Shelton, Bibianna M Purgina, Nicole A Cipriani, William D Dupont, Dale Plummer, James S Lewis
High-risk human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas have a more favorable prognosis than HPV-negative ones. p16 immunohistochemistry has been recommended as a prognostic test in clinical practice. Several p16 antibodies are available, and their performance has not been directly compared. We evaluated three commercially available p16 antibody clones (E6H4, JC8 and G175-405) utilizing 199 cases of oropharyngeal squamous cell carcinoma from a tissue microarray, read by three pathologists with three different cutoffs for positivity: any staining, >50% and >75%...
June 16, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28620984/saliva-testing-for-hpv-in-oropharyngeal-squamous-cell-carcinoma-opscc-a-diagnostic-accuracy-study
#16
Ali Qureishi, Mohammad Ali, Lisa Fraser, Ketan A Shah, Henrik Møller, Stuart Winter
BACKGROUND: New cases of oropharyngeal squamous cell carcinoma (OPSCC) are routinely tested for HPV. HPV in saliva can be detected with PCR, but its clinical applicability in the context of OPSCC remains unknown. METHODS: Forty-six consecutive patients diagnosed with OPSCC had pre-treatment saliva specimens collected. PCR for HPV on saliva was compared to p16 IHC and HPV DNA in-situ hybridisation (ISH) on surgical biopsies. RESULTS: The sensitivity and specificity of saliva testing when compared to the reference test of p16 IHC and HPV DNA ISH was 72...
June 16, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28619685/molecular-mechanisms-of-human-papillomavirus-related-carcinogenesis-in-head-and-neck-cancer
#17
REVIEW
Farhoud Faraji, Munfarid Zaidi, Carole Fakhry, Daria A Gaykalova
This review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV-positive HNSCC and the genome-wide changes associated with this disease.
June 12, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28608925/osteoradionecrosis-of-the-mandible-in-patients-with-oropharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy
#18
Francesca Caparrotti, Shao Hui Huang, Lin Lu, Scott V Bratman, Jolie Ringash, Andrew Bayley, John Cho, Meredith Giuliani, John Kim, John Waldron, Aaron Hansen, Li Tong, Wei Xu, Brian O'Sullivan, Robert Wood, David Goldstein, Andrew Hope
BACKGROUND: Osteoradionecrosis (ORN) of the mandible is a late toxicity affecting patients treated with radiotherapy for head and neck malignancies. To the authors' knowledge, ORN has no standardized grading system and its reporting is based on retrospective findings in heterogeneous patient populations. The rate of ORN in the era of intensity-modulated radiotherapy (IMRT) still is unknown. METHODS: The authors report the incidence of ORN from prospectively collected data regarding 1196 patients who were diagnosed with squamous cell carcinoma of the oropharynx and treated with curative-intent IMRT, with or without concomitant systemic treatment, from January 2005 to December 2014...
June 13, 2017: Cancer
https://www.readbyqxmd.com/read/28607924/hipk2-overexpression-and-its-prognostic-role-in-human-papillomavirus-positive-tonsillar-squamous-cell-carcinoma
#19
Mi Jung Kwon, So Young Kang, Eun Sook Nam, Seong Jin Cho, Young-Soo Rho
Tonsillar squamous cell carcinomas (TSCCs) are the most common human papillomavirus- (HPV-) associated oropharyngeal cancers with poor prognosis. Homeodomain-interacting protein kinase 2 (HIPK2) is a central regulator of p53, which participates in apoptosis during the DNA damage response. HIPK2 is involved in HPV-associated uterine cervical and cutaneous carcinogenesis through its binding of HPV E6, thereby preventing apoptosis and contributing to tumor progression. However, its clinical and prognostic significance in TSCC remains unclear...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28601094/prognostic-factors-for-head-and-neck-cancer-of-unknown-primary-including-the-impact-of-human-papilloma-virus-infection
#20
Lars Axelsson, Jan Nyman, Hedda Haugen-Cange, Mogens Bove, Leif Johansson, Shahin De Lara, Anikó Kovács, Eva Hammerlid
BACKGROUND: Head and neck cancer of unknown primary (HNCUP) is rare and prospective studies are lacking. The impact of different prognostic factors such as age and N stage is not completely known, the optimal treatment is not yet established, and the reported survival rates vary. In the last decade, human papilloma virus (HPV) has been identified as a common cause of and important prognostic factor in oropharyngeal cancer, and there is now growing interest in the importance of HPV for HNCUP...
June 10, 2017: Journal of Otolaryngology—Head & Neck Surgery
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