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Oropharyngeal squamous cell carcinoma

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https://www.readbyqxmd.com/read/28799537/hpv-16-in-a-distinct-subset-of-oral-epithelial-dysplasia
#1
Mark A Lerman, Soulafa Almazrooa, Neal Lindeman, Dimity Hall, Alessandro Villa, Sook-Bin Woo
Human papillomavirus (HPV) 16 is the most common high-risk HPV type identified in oropharyngeal and cervical neoplasia. Recently, HPV-associated oral epithelial dysplasia with specific histopathologic features and demographics similar to HPV-oropharyngeal carcinoma has been identified. The objective of this study was to evaluate histopathologically all cases of HPV-oral epithelial dysplasia seen in one center and identify HPV types in a subset of cases. Cases with specific histopathology for HPV-oral epithelial dysplasia that were positive both by immunohistochemical studies for p16 and by in situ hybridization for high-risk types of HPV were further analyzed using QIAamp DNA Tissue Kits (Qiagen, Hilden, Germany)...
August 11, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28797447/evaluation-of-the-xpert%C3%A2-hpv-assay-in-the-detection-of-human-papillomavirus-in-formalin-fixed-paraffin-embedded-oropharyngeal-carcinomas
#2
Maria Gabriella Donà, Francesca Rollo, Barbara Pichi, Giuseppe Spriano, Raul Pellini, Renato Covello, Edoardo Pescarmona, Giulia Fabbri, Manuela Scalfari, Tarik Gheit, Maria Benevolo
OBJECTIVES: The increasing incidence of HPV-related Oropharyngeal Squamous Cell Carcinoma (OPSCC) and the improved survival of HPV-positive OPSCC highlight the need for effective tools in evaluating HPV status on formalin-fixed paraffin-embedded (FFPE) cancers. To date, there is no agreement regarding the most appropriate method for HPV testing on FFPE materials. We aimed to investigate the performance of the Xpert® HPV assay (Cepheid) on crude lysates from OPSCC FFPE tissues. MATERIALS AND METHODS: Crude lysates were obtained by proteinase K digestion of FFPE tissues that had already been analyzed by the INNO-LiPA HPV assay and p16(ink4a) immunostaining...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797445/characteristics-and-long-term-outcomes-of-head-and-neck-squamous-cell-carcinoma-after-solid-organ-transplantation
#3
Samer Alsidawi, Katharine A Price, Ashish V Chintakuntlawar, Gustavo F Westin, Joaquin J Garcia, Daniel J Ma, Scott H Okuno
INTRODUCTION: Immunosuppression after solid organ transplant prevents graft rejection, but leads to increased incidence of various malignancies including head and neck squamous cell carcinoma (HNSCC). Outcomes of patients with post-transplant HNSCC are unknown. MATERIALS AND METHODS: We retrospectively identified patients who developed HNSCC after solid organ transplant between 1995 and 2010. Adults with pathology-proven HNSCC and adequate follow up were included...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28782304/primary-treatment-for-oropharyngeal-squamous-cell-carcinoma-in-alberta-canada-a-population-based-study
#4
Amy J Hobbs, Nigel T Brockton, T Wayne Matthews, Shamir P Chandarana, Pinaki Bose, Kelly Guggisberg, Gordon H Fick, Joseph C Dort
BACKGROUND: The incidence of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) is increasing and has better survival than non-HPV related oropharyngeal SCC. This study compared surgical to nonsurgical treatments and demographic, clinical, and survival differences in patients with oropharyngeal SCC, stratified by p16 status. METHODS: We assembled a cohort of adult patients with oropharyngeal SCC diagnosed between 2000 and 2008 in Alberta...
August 7, 2017: Head & Neck
https://www.readbyqxmd.com/read/28777690/development-and-validation-of-nomograms-predictive-of-overall-and-progression-free-survival-in-patients-with-oropharyngeal-cancer
#5
Carole Fakhry, Qiang Zhang, Phuc Felix Nguyen-Tân, David I Rosenthal, Randal S Weber, Louise Lambert, Andy M Trotti, William L Barrett, Wade L Thorstad, Christopher U Jones, Sue S Yom, Stuart J Wong, John A Ridge, Shyam S D Rao, James A Bonner, Eric Vigneault, David Raben, Mahesh R Kudrimoti, Jonathan Harris, Quynh-Thu Le, Maura L Gillison
Purpose Treatment of oropharyngeal squamous cell carcinoma (OPSCC) is evolving toward risk-based modification of therapeutic intensity, which requires patient-specific estimates of overall survival (OS) and progression-free survival (PFS). Methods To develop and validate nomograms for OS and PFS, we used a derivation cohort of 493 patients with OPSCC with known p16 tumor status (surrogate of human papillomavirus) and cigarette smoking history (pack-years) randomly assigned to clinical trials using platinum-based chemoradiotherapy (NRG Oncology Radiation Therapy Oncology Group [RTOG] 0129 and 0522)...
August 4, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28764811/survival-impact-of-pre-treatment-neutrophils-on-oropharyngeal-and-laryngeal-cancer-patients-undergoing-definitive-radiotherapy
#6
Whitney A Sumner, William A Stokes, Ayman Oweida, Kiersten L Berggren, Jessica D McDermott, David Raben, Diana Abbott, Bernard Jones, Gregory Gan, Sana D Karam
BACKGROUND: Squamous cell carcinoma of the head and neck (HNSCC) represents an array of disease processes with a generally unfavorable prognosis. Inflammation plays an important role in tumor development and response to therapy. We performed a retrospective analysis of HNSCC patients to explore the relationship of the lymphocyte and neutrophil counts, the neutrophil-to-lymphocyte ratio (NLR) overall survival (OS), cancer-specific survival (CSS), local control (LC) and distant control (DC)...
August 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28758552/correlation-between-hpv-status-at-t-and-n-sites-of-oropharyngeal-squamous-cell-carcinomas
#7
Michael Vallop Josiassen, Birgitte Charabi, Christel Braemer Lajer, Emilie Garnaes, Marianne Hamilton Therkildsen, Bodil Norrild, Lena Specht, Finn Cilius Nielsen, Christian von Buchwald
OBJECTIVES: Human papilloma virus (HPV) is known to be associated with oropharyngeal squamous cell carcinomas (OPSCC) and may potentially play a vital role in tumor metastasis. The purpose of this study was to correlate HPV status of cervical lymph node metastases with their respective primary OPSCC tumor. METHODS: Formalin-fixed, paraffin-embedded (FFPE) tissue samples obtained from 34 patients with cervical lymph node metastases were analyzed with HPV 16 DNA polymerase chain reaction (PCR), p16 immunohistochemistry and HPV typing...
July 30, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28758272/transoral-robotic-retropharyngeal-node-dissection-in-oropharyngeal-squamous-cell-carcinoma-patterns-of-metastasis-and-functional-outcomes
#8
Scott Troob, Babak Givi, Macgregor Hodgson, Alia Mowery, Neil D Gross, Peter E Andersen, Daniel Clayburgh
BACKGROUND: Assessment of the retropharyngeal lymph nodes is essential in the treatment for oropharyngeal squamous cell carcinoma (SCC). Transoral robotic retropharyngeal lymph node dissection (RPLND) may provide valuable staging information and guide selection of adjuvant therapy in a transoral robotic surgery (TORS) treatment paradigm. METHODS: Outcomes were compared between 30 patients with oropharyngeal SCC with tonsillar primaries undergoing RPLND and 37 stage-matched cases without RPLND...
July 31, 2017: Head & Neck
https://www.readbyqxmd.com/read/28758200/endoscopic-screening-for-synchronous-esophageal-neoplasia-among-patients-with-incident-head-and-neck-cancer-prevalence-risk-factors-and-outcomes
#9
Yao-Kuang Wang, Yun-Shiuan Chuang, Tzung-Shiun Wu, Ka-Wo Lee, Che-Wei Wu, Hsiang-Chen Wang, Chie-Tong Kuo, Chien-Hung Lee, Wen-Rei Kuo, Chung-Ho Chen, Deng-Chyang Wu, I-Chen Wu
Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. 815 incident HNSCC patients were prospectively recruited for endoscopy screening for ESCN using white-light imaging, narrow-band imaging, Lugol chromoendoscopy, and pathological confirmation. Associated lifestyle and clinicopathological data were collected...
July 30, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28752235/prognostic-implications-of-human-papillomavirus-status-for-patients-with-non-oropharyngeal-head-and-neck-squamous-cell-carcinomas
#10
Huaising C Ko, Paul M Harari, Ryan M Sacotte, Shuai Chen, Aaron M Wieland, Menggang Yu, Andrew M Baschnagel, Justine Y Bruce, Randall J Kimple, Matthew E Witek
PURPOSE: We examined overall survival in a large cohort of patients with human papillomavirus (HPV)-positive and HPV-negative non-oropharyngeal squamous cell carcinoma of the head and neck (non-OPSCC). METHODS: Patients diagnosed with non-OPSCC and known HPV status were identified in the National Cancer Database (NCDB). Multivariate logistic regression was applied to examine factors associated with HPV status. Multivariate analysis was utilized to determine factors correlated with overall survival...
July 27, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28751709/lymph-node-ratio-is-associated-with-adverse-clinicopathological-features-and-is-a-crucial-nodal-parameter-for-oral-and-oropharyngeal-cancer
#11
Zhien Feng, Qiao Shi Xu, Chong Wang, Jin Zhong Li, Ming Hui Mao, Hua Li, Li Zheng Qin, Zhengxue Han
The lymph node ratio(LNR) has been described as a novel predictor of the survival of patients with oral and oropharyngeal squamous cell carcinoma(O/OPSCC). The purpose of this study was to evaluate whether LNR is better at predicting survival and the need for adjuvant treatment than traditional tumour-nodal-metastasis(TNM) staging. Eight hundred nine patients with O/OPSCC and positive lymph node disease were retrospectively enrolled in this study. LNR equal to 0.075 is the best cut-off value for stratifying 5-year disease-free survival(DFS)...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743604/clinicopathological-features-management-and-outcome-of-patients-with-poorly-differentiated-oral-and-oropharyngeal-squamous-cell-carcinoma
#12
Zhien Feng, Qiao Shi Xu, Chong Wang, Bo Li, Jin Zhong Li, Ming Hui Mao, Hua Li, Li Zheng Qin, Zhengxue Han
BACKGROUND: The purpose of this study was to explore the clinicopathological features, risk factors, and management of poorly differentiated oral and oropharyngeal squamous cell carcinoma (OOSCC) patients in the northern Chinese population. METHOD: A total of 118 poorly differentiated OOSCC patients from 2236 consecutive cases were retrospectively enrolled in this study. RESULTS: Cox regression analysis showed that site (hazard ratio (HR): 2...
July 4, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28743201/pharyngotomy-in-head-and-neck-squamous-cell-carcinoma-functional-and-oncological-aspects
#13
Carolin Remmert, Naglaa Mansour, Benedikt Hofauer, Elias Q Scherer, Murat Bas, Henning Bier, Andreas Knopf
BACKGROUND: Head and Neck Surgery constantly has to oppose non-invasive organ preservation methods and therefore should be evaluated especially with regard to clinical and functional outcome. We will discuss the role of pharyngotomy in the treatment of HNSCC. METHODS: Seventy-three patients with carcinoma of the oral cavity, oro-/hypopharynx and supraglottis underwent lateral/median pharyngotomy. Functional and oncological parameters were retrospectively assessed and set into clinical context...
July 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28737019/clinical-outcomes-for-patients-presenting-with-n3-head-and-neck-squamous-cell-carcinoma-analysis-of-the-national-cancer-database
#14
Huaising C Ko, Shuai Chen, Aaron M Wieland, Menggang Yu, Andrew M Baschnagel, Gregory K Hartig, Paul M Harari, Matthew E Witek
BACKGROUND: There is a paucity of data regarding head and neck squamous cell carcinomas (HNSCCs) and N3 nodal disease. METHODS: Retrospective analysis of patients with N3 HNSCC identified in the National Cancer Database (NCDB) was performed. RESULTS: We identified 4867 patients with N3 HNSCC treated with primary surgery or chemoradiotherapy (CRT). Propensity-adjusted median survival was 54.2 and 44.8 months for surgery and CRT, respectively (P = ...
July 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/28733453/a-novel-functional-splice-variant-of-akt3-defined-by-analysis-of-alternative-splice-expression-in-hpv-positive-oropharyngeal-cancers
#15
Theresa Guo, Akihiro Sakai, Bahman Afsari, Michael Considine, Ludmila Danilova, Alexander V Favorov, Srinivasan Yegnasubramanian, Dylan Z Kelley, Emily Flam, Patrick K Ha, Zubair Khan, Sarah J Wheelan, J Silvio Gutkind, Elana J Fertig, Daria A Gaykalova, Joseph Califano
The incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) has increased more than 200% in the past 20 years. Recent genetic sequencing efforts have elucidated relevant genes in head and neck cancer, but HPV-related tumors have consistently shown few DNA mutations. In this study, we sought to analyze alternative splicing events (ASE) that could alter gene function independent of mutations. To identify ASE unique to HPV-related tumors, RNA sequencing was performed on 46 HPV-positive OPSCC and 25 normal tissue samples...
July 21, 2017: Cancer Research
https://www.readbyqxmd.com/read/28732044/the-prognostic-impact-of-human-papillomavirus-status-following-treatment-failure-in-oropharyngeal-cancer
#16
Eesha Dave, Umut Ozbek, Vishal Gupta, Eric Genden, Brett Miles, Marita Teng, Marshall Posner, Krzysztof Misiukiewicz, Richard L Bakst
INTRODUCTION: Despite the human papillomavirus conferring a better prognosis in the primary treatment setting, the prognostic impact of viral status after treatment failure in oropharyngeal squamous cell carcinoma patients is poorly understood. METHODS: We retrospectively identified 33 oropharyngeal squamous cell carcinoma (OPC) patients with local and/or distant disease recurrence post-treatment, and looked at metastatic patterns, time to failure and survival patterns by HPV status...
2017: PloS One
https://www.readbyqxmd.com/read/28725009/the-salivary-microbiome-as-an-indicator-of-carcinogenesis-in-patients-with-oropharyngeal-squamous-cell-carcinoma-a-pilot-study
#17
Axel Wolf, Christine Moissl-Eichinger, Alexandra Perras, Kaisa Koskinen, Peter V Tomazic, Dietmar Thurnher
This study aimed to undertake an initial, comparative analysis of the oral salivary microbiome of patients with oral and oropharyngeal squamous cell carcinoma versus healthy controls. This project, conceived as a pilot study, included 11 patients (1 female, 10 male, mean age 61.6 yrs., SD = 8.2 yrs.) and 11 healthy controls (1 female, 10 male, mean age 46.7 yrs., SD = 15.1 yrs.). Samples of saliva were analysed by high-throughput sequencing of the 16S rRNA gene using the MiSeq platform. Sequence data revealed microbial changes that may mirror disease progression and reflect clinical preconditions such as age, alcohol consumption, tumour size, lymph node status, smoking habit, and tumour HPV-positivity...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28722666/tumor-pd-l1-status-and-cd8-tumor-infiltrating-t-cells-markers-of-improved-prognosis-in-oropharyngeal-cancer
#18
Astrid De Meulenaere, Tijl Vermassen, Sandrine Aspeslagh, Philippe Deron, Fréderic Duprez, Debby Laukens, Jo Van Dorpe, Liesbeth Ferdinande, Sylvie Rottey
INTRODUCTION: The aim of this study was to evaluate the expression of PD-L1 in oropharyngeal squamous cell carcinoma. Its relation with clinicopathological variables such as amount and type of tumor infiltrating lymphocytes, HPV status and survival was also determined. RESULTS: Positive PD-L1 status for the SP142 clone related with improved overall survival in oropharyngeal squamous cell carcinoma. Tumors heavily infiltrated by tumor infiltrating lymphocytes were also linked with better outcome, and this as well for the total number of tumor infiltrating lymphocytes as for the CD3+ and CD8+ T cell count...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28721884/dosimetric-predictors-of-patient-reported-xerostomia-and-dysphagia-with-deintensified-chemoradiation-therapy-for-hpv-associated-oropharyngeal-squamous-cell-carcinoma
#19
Bhishamjit S Chera, David Fried, Alex Price, Robert J Amdur, William Mendenhall, Chiray Lu, Shiva Das, Nathan Sheets, Lawrence Marks, Panayiotis Mavroidis
PURPOSE/OBJECTIVE(S): To estimate the association between different dose-volume metrics of the salivary glands and pharyngeal constrictors with patient reported severity of xerostomia/dysphagia in the setting of deintensified chemoradiation therapy (CRT). METHODS AND MATERIALS: Forty-five patients were treated on a phase 2 study assessing the efficacy of deintensified CRT for favorable-risk, HPV-associated oropharyngeal squamous cell carcinoma. Patients received 60 Gy intensity modulated radiation therapy with concurrent weekly cisplatin (30 mg/m(2)), and reported the severity of their xerostomia/dysphagia (before and after treatment) using the patient-reported outcome version of the Common Terminology Criteria for Adverse Events (CTCAE) (PRO-CTCAE)...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28719715/long-term-recurrence-free-survival-after-an-unplanned-reduction-in-radiotherapy-for-hpv-positive-oropharyngeal-scc-two-cases-and-a-review-of-the-literature
#20
Jason Liu, David Goldenberg, Salah Almokadem, Henry Crist, Heath B Mackley
There is currently no clear distinction between the treatment of HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma (OPSCC). HPV-positive OPSCC has been demonstrated to be more radiosensitive than its HPV-negative counterpart. Despite this, patients with HPV-positive OPSCC continue to receive a full dose of radiation (70 Gy) outside clinical trials. However, this high dose comes with considerable morbidities, including severe mucositis, dysphagia, and xerostomia. We describe the cases of 2 patients with HPV-positive OPSCC who received two cycles of high-dose cisplatin at 100 mg/m(2) on 3 separate days, along with concurrent radiotherapy at 50 Gy in 25 fractions for one and 46 Gy in 23 fractions for the other...
July 2017: Ear, Nose, & Throat Journal
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