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Mathew Clark, Esma Birisci, Jordan E Anderson, Christina M Anliker, Micheal A Bryant, Craig Downs, Abdallah Dalabih
BACKGROUND: Current guidelines adopted by the American Academy of Pediatrics calls for prolonged fasting times before performing pediatric procedural sedation and analgesia (PSA). PSA is increasingly provided to children outside of the operating theater by sedation trained pediatric providers and does not require airway manipulation. We investigated the safety of a shorter fasting time compared to a longer and guideline compliant fasting time. We tried to identify the association between fasting time and sedation-related complications...
September 2016: Anesthesia, Essays and Researches
Eliane H Dutra, Mara H O' Brien, Alexandro Lima, Zana Kalajzic, Aditya Tadinada, Ravindra Nanda, Sumit Yadav
OBJECTIVES: To evaluate the cellular and matrix effects of botulinum toxin type A (Botox) on mandibular condylar cartilage (MCC) and subchondral bone. MATERIALS AND METHODS: Botox (0.3 unit) was injected into the right masseter of 5-week-old transgenic mice (Col10a1-RFPcherry) at day 1. Left side masseter was used as intra-animal control. The following bone labels were intraperitoneally injected: calcein at day 7, alizarin red at day 14 and calcein at day 21. In addition, EdU was injected 48 and 24 hours before sacrifice...
2016: PloS One
Sandi Berwick, Áine Humble
Seven women (43 to 64 years old) who had negative or mixed emotions about having Botox and/or facial filler injections to the face to reduce signs of aging were interviewed about the impact of the procedures. Impacts ranged from disappointment to all-encompassing, lingering physical and psychological effects, and some women felt abandoned by the medical industrial complex when they turned to it for help with their symptoms. A feminist phenomenological analysis focused on corporeal, temporal, and relational existential modes of being...
August 11, 2016: Journal of Women & Aging
Pawel Miotla, Rufus Cartwright, Katarzyna Skorupska, Michal Bogusiewicz, Ewa Markut-Miotla, Konrad Futyma, Tomasz Rechberger
AIMS: Urgency urinary incontinence (UUI), and the symptoms of overactive bladder (OAB) have a negative impact on female sexual function. The aim of this study was to investigate the effect of intravesical onabotulinumtoxinA (Botox) injection on sexual function in women with OAB, using the multi domain Female Sexual Function Index (FSFI) questionnaire. METHODS: Sixty-eight sexually active women with idiopathic OAB with at least one episode of UUI and ≥8 micturitions per 24 h were recruited...
October 4, 2016: Neurourology and Urodynamics
Sophie Larrazet, Romain Joste, Angélique Stefan, Anne Delaubier, André Gueyraud, Philippe Foucault, Claire Guillou, Thierry Dabbadie
OBJECTIVE: The aim of this study was to compare the analgesic effectiveness of 1 month injection after botulinum toxin in the pectoralis major muscle or subscapularis. MATERIAL/PATIENTS AND METHODS: In this prospective, comparative, randomized, multicenter trial, 21 patients with hemiplegic shoulder pain after a recent stroke (less 6 months) were screened at baseline, then postinjection (Botox(®) 150 units pectoralis major, 100 units subscaplaris) at 1, 4 and 12 weeks...
September 2016: Annals of Physical and Rehabilitation Medicine
Christelle Pons, Dinomais Mickael, Franck Fitoussi, Marie-Charlotte D'Anjou, Mélanie Porte, Emilie Rumilly, Nathaly Quintero, Philippe Violas, Sylvain Brochard
OBJECTIVE: In children with obstetrical brachial plexus palsy (OBPP), shoulder musculoskeletal deformity is the main cause of morbidity, with a loss of range of shoulder motion, pain and a reduction in social participation. Some uncontrolled studies show that early injections of botulinum toxin (BTI) in the internal shoulder rotator muscles (which cause the deformity) are one of the most promising treatments for the prevention of bony deformity. The main objective of this study will be the evaluation of the effectiveness of BTI in the internal shoulder rotator muscles at the age of 6 months in preventing an increase in posterior subluxation of the glenohumeral joint in babies with OBPP (evaluated at the ages of 5 and 12 months), compared with a placebo...
September 2016: Annals of Physical and Rehabilitation Medicine
Aurélie Rochefolle, Emmanuelle Carré, Aurélie Rochefolle, Marie Callies de Sallies, Florence Durand, Catherine Rioufol, Jacques Luaute, Gilles Rode
OBJECTIVE: Botulinum toxins are often prescribed in aftercare and neurological rehabilitation services. In our hospital, they are exponentially used in the treatment of spasticity. The objective of this study is to make an assessment of their use over the period 2012-2015. MATERIAL/PATIENTS AND METHODS: All the botulinum toxin prescriptions are followed by the chemists. A traceability form allows to collect information about the patient, the prescriber, the medicine and its dose, the cost, and the indication...
September 2016: Annals of Physical and Rehabilitation Medicine
Laura Weglinski, Rebecca Haddad, Benoit Peyronnet, Xavier Game, Calin Ciofu, Gerard Amarenco
OBJECTIVE: Intradetrusorial injection of botulinum toxin A (IDBT) is a validated treatment for neurogenic and non-neurogenic refractory overactive bladder. In the elderly, muscarinic antagonists have many side effects, in particular in cognition. An alternative treatment is, for that reason, interesting in this frail population with multiple medication use. The question of efficacy is remaining. Indeed, bladder dysfunction is most of the time a multifactorial issue in the elderly. The objective of this study was to evaluate prospectively the efficacy and safety of IDBT in this population...
September 2016: Annals of Physical and Rehabilitation Medicine
Reza Kordestani, Kevin H Small, Rod J Rohrich
The use of neuromodulators has increased by approximately 748 percent from 2000 to 2014 and has become an integral adjunct for facial rejuvenation. Knowledge of facial anatomy, accurate facial analysis, and familiarity with neurotoxin characteristics will minimize complications and optimize results. Current U.S. Food and Drug Administration-approved neurotoxins in the United States include onabotulinumtoxin A (Botox), abobotulinumtoxin A (Dysport), and incobotulinumtoxin A (Xeomin). The dosage and effect of these products are not interchangeable, so practitioners should master the utility and response of one product before trying the other products...
October 2016: Plastic and Reconstructive Surgery
Rucha Kharod, Prateek Grover, Rimma Ruvinskaya
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Yao-Hong Guo, Ta-Shen Kuan, Kuan-Lin Chen, Wei-Chih Lien, Pei-Chun Hsieh, I-Chieh Hsieh, Szu-Hao Chiu, Yu-Ching Lin
OBJECTIVES: To compare the effects of two different injection sites of low doses of botulinum toxin type A with steroid in treating lateral epicondylalgia. DESIGN: Double-blind, randomized, active drug-controlled trial. SETTING: Tertiary medical center. PARTICIPANTS: Twenty-six patients with lateral epicondylalgia for more than six months were recruited from hospital-based outpatient population. A total of 66 patients were approached, and 40 were excluded...
September 22, 2016: Archives of Physical Medicine and Rehabilitation
Jeffrey C Eickhoff, Jonathan K Smith, Mark E Landau, Jess D Edison
No abstract text is available yet for this article.
October 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Jun Li, Qian Li, Bei Zhou, Yanli Gao, Jiehua Ma, Jingyun Li
BACKGROUND: Cosmetic surgery is becoming increasingly popular in China. However, reports on the predictive factors for cosmetic surgery in Chinese individuals are scarce in the literature. METHODS: We retrospectively analyzed 4550 cosmetic surgeries performed from January 2010 to December 2014 at a single center in China. Data collection included patient demographics and type of cosmetic surgery. Predictive factors were age, sex, marital status, occupational status, educational degree, and having had children...
2016: SpringerPlus
I Dominique, A Bourmaud, B Tamarelle, J E Terrier, A Ruffion
INTRODUCTION: Preoperative information before bladder wall injection of botulinum toxin A (Botox(®)) holds several essential facts to understand and retain by the patients. The aim of this study was a review of essential preoperative information items according to GENULF medical experts. METHOD: It was a prospective review from December 2015 to April 2016. Three Delphi rounds had been done from the Survey Monkey(®) software. The initial questionnaire was composed of items from the patient information sheet edited by the GENULF...
September 16, 2016: Progrès en Urologie
Michail Vikelis, Andreas A Argyriou, Emmanouil V Dermitzakis, Konstantinos C Spingos, Dimos D Mitsikostas
BACKGROUND: Chronic migraine is a disabling condition, with limited treatment options. We conducted an open label, single arm, prospective clinical trial, to assess the efficacy and safety of onabotulinumtoxin-A in Greek patients with chronic migraine. Since recent evidence suggests that a meaningful clinical response may be delayed until after a third onabotulinumtoxin-A administration, we aimed at assessing outcomes at this time point. METHODS: A total of 119 patients with CM, scheduled to be treated with Onabotulinumtoxin-A (Botox ®) every 3 months, according to the approved indication and standard clinical practice, were prospectively enrolled...
December 2016: Journal of Headache and Pain
Jeong-Gue Choi, Joon-Ho Shin, Bo-Ra Kim
OBJECTIVE: To evaluate the beneficial effect of botulinum toxin A (Botox) injection into the subscapularis muscle on intractable hemiplegic shoulder pain. METHODS: Six stroke patients with intractable hemiplegic shoulder pain were included. Botulinum toxin A was injected into the subscapularis muscle. Intractable hemiplegic shoulder pain was evaluated using an 11-point numerical rating scale. Pain-free range of motion was assessed for shoulder abduction and external rotation...
August 2016: Annals of Rehabilitation Medicine
Virginie Woisard, Xuelai Liu, Marie Christine Arné Bes, Marion Simonetta-Moreau
Data, regarding the use of botulinum toxin (BT-A) in laryngeal dyspnea, are scarce, coming from some cases reports in the literature, including Vocal fold paralysis, laryngeal dystonia, vocal cord dysfunction also called paradoxical motion of the vocal fold (PMVF), and post-neuroleptic laryngeal dyskinesia. There is no consensus regarding the muscles and the doses to inject. The aim of this study is to present a retrospective review of patients treated in our ENT Department by BT-A injection in this indication...
September 6, 2016: European Archives of Oto-rhino-laryngology
Michael F Vaezi, Valter N Felix, Roberto Penagini, Aurelio Mauro, Eduardo Guimarães Hourneaux de Moura, Leonardo Zorrón Cheng Tao Pu, Jan Martinek, Erwin Rieder
Achalasia is an esophageal motility disorder associated with abnormalities in peristalsis and lower esophageal sphincter (LES) relaxation. The etiology of the disease remains elusive. It is often misdiagnosed initially as gastroesophageal reflux disease. Patients with achalasia often complain of dysphagia to solids and liquids but may focus on regurgitation as the primary symptom, leading to the early misdiagnosis. Chest pain, weight loss, and occasional vomiting may be additional symptoms encountered in those with achalasia...
August 29, 2016: Annals of the New York Academy of Sciences
Anthony G Visco, Halina Zyczynski, Linda Brubaker, Ingrid Nygaard, Xiao Xu, Emily S Lukacz, Marie Fidela Paraiso, Jerod Greer, David D Rahn, Susan F Meikle, Amanda A Honeycutt
OBJECTIVES: This study aimed to compare the cost-effectiveness of Botox and anticholinergic (AC) medications for the management of urgency urinary incontinence (UUI). METHODS: Cost and effectiveness data were analyzed from participants in the Anticholinergic versus Botox Comparison randomized trial of daily AC medication versus 100 U of intradetrusor Botox injection. Societal costs included the following: treatment costs, patient costs, and medical and nonmedical utilization during the 6-month trial...
September 2016: Female Pelvic Medicine & Reconstructive Surgery
Adam Bobkiewicz, Wojciech Francuzik, Lukasz Krokowicz, Adam Studniarek, Witold Ledwosiński, Jacek Paszkowski, Michal Drews, Tomasz Banasiewicz
BACKGROUND: Chronic anal fissure (CAF) is a linear split of the anoderm. The minimally invasive management of CAF such as botulinum toxin (BT) injection is recommended. However, the exact efficient dose of BT, number of injections per session and the injection sites are still debatable. The aim of this analysis was to assess the dose-dependent efficiency of botulinum toxin injection for CAF. METHODS: PubMed and Web of Science databases were searched for terms: "anal fissure" AND "botulinum toxin...
August 18, 2016: World Journal of Surgery
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