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https://www.readbyqxmd.com/read/28914679/reliability-of-a-skin-diagnostic-device-in-assessing-hydration-and-erythema
#1
Koh Huimin, Alexandra M Rowledge, Caroline J Borzdynski, Charne Miller, Nicoletta Frescos, Gayle McKenzie, Elizabeth Perry, William McGuiness
OBJECTIVE: To examine the reliability of a skin diagnostic device, the SD202 (Courage+Khazaka GmBH, Cologne, Germany), in assessing hydration and erythema of periwound skin and pressure injury-prone areas. DESIGN: Intrarater reliabilities from 3 cross-sectional and prospective studies are reported. SETTING AND PARTICIPANTS: Patients attending an outpatient, nurse-led wound dressing clinic (n = 16), a podiatrist-led high-risk foot clinic (n = 17), and residents (n = 38) at a single residential aged-care facility...
October 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28912573/low-magnitude-high-frequency-vibration-accelerated-the-foot-wound-healing-of-n5-streptozotocin-induced-diabetic-rats-by-enhancing-glucose-transporter-4-and-blood-microcirculation
#2
Caroline Oi-Ling Yu, Kwok-Sui Leung, Jonney Lei Jiang, Tina Bai-Yan Wang, Simon Kwoon-Ho Chow, Wing-Hoi Cheung
Delayed wound healing is a Type 2 diabetes mellitus (DM) complication caused by hyperglycemia, systemic inflammation, and decreased blood microcirculation. Skeletal muscles are also affected by hyperglycemia, resulting in reduced blood flow and glucose uptake. Low Magnitude High Frequency Vibration (LMHFV) has been proven to be beneficial to muscle contractility and blood microcirculation. We hypothesized that LMHFV could accelerate the wound healing of n5-streptozotocin (n5-STZ)-induced DM rats by enhancing muscle activity and blood microcirculation...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28904951/diabetic-foot-ulcers-and-epidermal-growth-factor-revisiting-the-local-delivery-route-for-a-successful-outcome
#3
REVIEW
Jorge Berlanga-Acosta, José Fernández-Montequín, Calixto Valdés-Pérez, William Savigne-Gutiérrez, Yssel Mendoza-Marí, Ariana García-Ojalvo, Viviana Falcón-Cama, Diana García Del Barco-Herrera, Maday Fernández-Mayola, Héctor Pérez-Saad, Eulogio Pimentel-Vázquez, Aleida Urquiza-Rodríguez, Moshe Kulikovsky, Gerardo Guillén-Nieto
Soon after epidermal growth factor (EGF) discovery, some in vivo models appeared demonstrating its property to enhance cutaneous wound healing. EGF was the first growth factor (GF) introduced in the clinical arena as a healing enhancer, exerting its mitogenic effects on epithelial, fibroblastoid, and endothelial cells via a tyrosine kinase membrane receptor. Compelling evidences from the 90s documented that, for EGF, locally prolonged bioavailability and hourly interaction with the receptor were necessary for a successful tissue response...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28895073/efficacy-and-time-sensitivity-of-amniotic-membrane-treatment-in-patients-with-diabetic-foot-ulcers-a-systematic-review-and-meta-analysis
#4
REVIEW
Irakoze Laurent, Manirakiza Astère, Kan Ran Wang, Qing-Feng Cheng, Qi Fu Li
INTRODUCTION: Diabetic foot ulcers (DFUs) are complex chronic wounds which have a major long-term impact on the morbidity, mortality and quality of patients. The objective of this study was to assess the efficacy and time sensitivity of human amnion/chorion membrane treatment in patients with chronic DFUs. METHODS: The Cochrane Library, PubMed, Embase and Web of Science databases were systematically searched to identify relevant articles up to 10 April 2017. All randomized controlled trials (RCTs) comparing human amnion/chorion membrane + standard therapy and standard therapy alone in patients with DFUs were included in the analysis...
September 11, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28894635/topical-naltrexone-is-a-safe-and-effective-alternative-to-standard-treatment-of-diabetic-wounds
#5
Patricia J McLaughlin, Jarrett D Cain, Michelle B Titunick, Joseph W Sassani, Ian S Zagon
Objective: Diabetes affects more than 29 million individuals in the United States, resulting in healthcare costs approaching $245 billion. Approximately 15% of these individuals will develop a chronic, non-healing foot ulcer (diabetic foot ulcer [DFU]) that, if untreated, may lead to amputation. The current treatments for DFU are expensive, have significant side-effects, and often result in non-compliance. A new topical treatment is described that accelerates cutaneous wound repair and is disease modifying by targeting underlying aberrant diabetic pathways...
September 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28889401/severity-of-drug-resistance-and-co-existence-of-enterococcus-faecalis-in-diabetic-foot-ulcer-infections
#6
Kavitha Shettigar, Deepika V Bhat, Kapaettu Satyamoorthy, Thokur Sreepathy Murali
The genes encoding aminoglycoside resistance in Enterococcus faecalis may promote collateral aminoglycoside resistance in polymicrobial wounds. We studied a total of 100 diabetic foot ulcer samples for infection and found 60 samples to be polymicrobial, 5 to be monomicrobial, and 35 samples to be culture negative. A total of 65 E. faecalis isolates were screened for six genes coding for aminoglycoside resistance, antibiotic resistance patterns, and biofilm production. Infectious Diseases Society of America/International Working Group on the Diabetic Foot system was used to classify the wound ulcers...
September 9, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28887854/human-tissue-inhibitor-of-metalloproteinases-1-improved-wound-healing-in-diabetes-through-its-anti-apoptotic-effect
#7
Guojuan Lao, Meng Ren, Xiaoyi Wang, Jinglu Zhang, Yanrui Huang, Dan Liu, Hengcong Luo, Chuan Yang, Li Yan
Impaired wound healing accompanies severe cell apoptosis in diabetic patients. Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) was known to have effects on promoting growth and anti-apoptosis for cells. we aimed to determine the actual levels of TIMP-1 and cell apoptosis in: 1) the biopsies of diabetic and non-diabetic foot tissue; 2) the human fibroblasts with or without treatments of Advanced Glycation End Products (AGEs). Next, in both human fibroblasts and the animal model of diabetic rats, to determine the improved levels of cell apoptosis and wound healing after the treatments of either active protein of TIMP-1 or in vivo expression of gene therapy vector-mediated TIMP-1...
September 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28887264/toe-pressures-are-superior-to-duplex-parameters-in-predicting-wound-healing-following-toe-and-foot-amputations
#8
Patrick A Stone, Alexis Glomski, Stephanie N Thompson, Elliott Adams
BACKGROUND: No criteria, including pre-amputation vascular diagnostic thresholds, have been established to reliably predict healing versus non-healing following minor lower extremity amputations. Thus, the goal of our study was to identify clinical factors, including non-invasive vascular laboratory measures, associated with wound healing following toe, forefoot, and midfoot amputations. METHODS: We retrospectively examined records of patients receiving elective toe, forefoot, or midfoot amputation at our institution over a 5-year span (2010-2015)...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28885652/vascularised-and-modified-lower-leg-rotationplasty-for-the-treatment-of-severe-infection-and-bone-loss-of-the-proximal-femur-a-case-report
#9
Sebastian Fischer, Christoph Hirche, Volkmar G Heppert, Paul A Grützner, Ulrich Kneser, Thomas Kremer
CASE DESCRIPTION: We report a reconstructive case in a paraplegic patient, who suffers from a severe proximal femur infection. Aiming at the preservation of the capacity to remain in a seated position to operate a wheelchair, lower leg rotationplasty was considered suitable for reconstruction. Due to severe infection and subclinical femoral artery stenosis, rotationplasty was supercharged by the inferior epigastric artery. Furthermore, extensor tendons of the foot were attached to the acetabulum to facilitate stability of the neo-hip joint...
September 2, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28881730/suppression-of-microrna-205-5p-in-human-mesenchymal-stem-cells-improves-their-therapeutic-potential-in-treating-diabetic-foot-disease
#10
Lingyan Zhu, Gongxian Wang, Shane Fischbach, Xiangwei Xiao
Diabetes is a prevalent disease endangering human health, while diabetic foot disease (DF) is one of the most severe complications of diabetes. Mesenchymal stem cells (MSCs) have been used in DF treatment, taking advantage of the differentiation potential of MSCs into endothelial cells and their production and secretion of trophic factors like vascular endothelial growth factor (VEGF). Molecular modification of MSCs to improve their therapeutic effects has been recently applied in treating other diseases, but not yet in DF...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28880752/evaluation-of-osteopontin-expression-in-chronic-wounds-a-potential-prognostic-and-therapeutic-biomarker
#11
S Chimento, V Billero, L Cavallin, M Romanelli, M Nadji, P Romanelli
OBJECTIVE: Osteopontin (OPN) is abundantly expressed during tissue repair, acting as a powerful chemokine that recruits inflammatory cells such as neutrophils, macrophages, and Langerhans cells. The role of OPN in chronic wounds has not been explored. In this study, we assess the expression levels of OPN in chronic wounds to assess its potential contribution to the exacerbated inflammation seen in chronic ulcers, which is thought to contribute to poor healing. METHODS: This retrospective study included archived biopsies of chronic wounds from several aetiologies...
September 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28880596/does-baseline-hemoglobin-a1c-level-predict-diabetic-foot-ulcer-outcome-or-wound-healing-time
#12
Lourdes Vella, Alfred Gatt, Cynthia Formosa
BACKGROUND: We sought to evaluate the relationship between baseline hemoglobin A1c (HbA1c) level and clinical outcomes, including foot ulcer outcome (resolved versus unresolved) and wound-healing time, in individuals with type 2 diabetes. METHODS: A prospective observational study was conducted on 99 patients presenting with a diabetic foot ulceration. Patient and ulcer characteristics were recorded. Patients were followed up for a maximum of 1 year. RESULTS: After 1 year of follow-up, 77% of ulcers healed and 23% did not heal...
July 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28880591/remote-ischemic-conditioningpromising-potential-in-wound-repair-in-diabetes
#13
Jano A Boghossian, Bellal Joseph, Marvin J Slepian, David G Armstrong
Remote ischemic conditioning involves the use of a blood pressure cuff or similar device to induce brief (3-5 min) episodes of limb ischemia. This, in turn, seems to activate a group of distress signals that has shown the potential ability to improve healing of the heart muscle and other organ systems. Until recently, this has not been tested in people with diabetic foot ulcers. The purpose of this review was to provide background on remote ischemic conditioning and recent data to potentially support its use as an adjunct to healing diabetic foot ulcers and other types of tissue loss...
July 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28877672/chronic-lower-extremity-wound-infection-due-to-kerstersia-gyiorum-in-a-patient-with-buerger-s-disease-a-case-report
#14
Irmak Baran, Arife Polat Düzgün, İpek Mumcuoğlu, Neriman Aksu
BACKGROUND: Kerstersia gyiorum is an extremely rare pathogen of human infection. It can cause chronic infection in patients with underlying conditions. It can easily be misdiagnosed if proper diagnostic methods are not used. CASE PRESENTATION: A 47-year-old male patient with a history of Buerger's Disease for 28 years presented to our hospital with an infected chronic wound on foot. The wound was debrided, and the specimen was sent to Microbiology laboratory. Gram staining of the specimen showed abundant polymorphonuclear leukocytes and gram-negative bacilli...
September 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28876452/management-of-primary-malignant-bone-and-soft-tissue-tumors-of-foot-and-ankle-is-it-worth-salvaging
#15
Harzem Özger, Buğra Alpan, Osman Emre Aycan, Natig Valiyev, Mustafa Çağlar Kir, Fulya Ağaoğlu
BACKGROUND AND OBJECTIVE: Performing limb salvage with safe margins and preserving meaningful function is very difficult in the setting of primary malignant bone and soft tissue tumors due to the complex and constrained anatomy of the foot and ankle. The study aims to evaluate the efficacy of limb salvage procedures in terms of functional and oncological outcomes. METHODS: Clinical data of 48 patients, who underwent surgical treatment between 1992 and 2015 in our institution, were retrospectively analyzed...
September 6, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28874067/sural-flap-use-for-the-treatment-of-wounds-with-underlying-osteomyelitis-graft-size-a-predictor-in-outcome-a-systematic-review
#16
Sham Persaud, Anthony Chesser, Ryan Pereira, Adrianne Ross
The sural flap procedure is a versatile technique that can be used to cover many types of defects about the lower extremity. The management of soft tissue defects of the lower extremity with underlying osteomyelitis is difficult. The goal for any of these patients is to create a biomechanically stable foot for weight-bearing purposes with no continued infection. Data were gathered using multiple databases from the years 2000 to 2016. Data were compiled looking at the number of subjects, age, comorbidities, number of complications, number of failures, and average flap size of complications/failures...
September 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28873060/a-retrospective-crossover-study-of-the-use-of-aseptically-processed-placental-membrane-in-the-treatment-of-chronic-diabetic-foot-ulcers
#17
Lawrence A DiDomenico, Dennis P Orgill, Robert D Galiano, Thomas E Serena, Marissa J Carter, Jarrod P Kaufman, Nathan J Young, Charles M Zelen
BACKGROUND: In a recently published, prospective randomized controlled trial (RCT) comparing aseptically processed dehydrated human amnion/chorion allograft (dHACA) to standard of care (SOC), 85% wound closure rates were reported in the dHACA arm while only 25% of patients in the SOC arm healed. OBJECTIVE: The purpose of this retrospective crossover study is to evaluate the effectiveness of dHACA in those patients that failed to respond to the SOC treatments and who exited the original study after failing up to 12 weeks of SOC treatment...
July 26, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28867139/bite-wounds-caused-by-a-wild-boar-a-case-report
#18
Hiroki Nagasawa, Kazuhiko Omori, Hiroyuki Maeda, Ikuto Takeuchi, Suguru Kato, Takashi Iso, Kei Jitsuiki, Toshihiko Yoshizawa, Kouhei Ishikawa, Hiromichi Ohsaka, Youichi Yanagawa
A 74-year-old man was attacked by a wild boar while on his way home from his farm in the daytime in winter 2017 on the rural Izu peninsula. He did not provoke the boar; however, hunters were hunting animals in the mountains near the farm around the same time. The boar bit his left leg, and the man fell to the ground. The boar continued biting the man's left leg, and the man delivered a few kicks to the boar's face with his right leg. The boar then bit his right foot and ran away. The man was taken to a hospital, and a physical examination revealed 3 bite wounds on his left leg and right foot...
August 31, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28865586/comparison-of-two-different-vacuum-assisted-closure-vac-treatments-of-multiple-chronic-diabetic-foot-wounds-in-the-same-extremity
#19
Meriç Uğurlar, Mesut Mehmet Sönmez, Raffi Armağan, Osman Tuğrul Eren
BACKGROUND: The aim of the present study is to compare the clinical efficacy and safety of two different vacuum-assisted closure (VAC) applications in one center between two groups of patients with Wagner Grade 3-4 multiple chronic diabetic foot wounds. METHODS: The study was a randomized-controlled, prospective investigation between two groups of patients with Wagner Grade 3-4 multiple chronic diabetic foot wounds at single extremity. There were 10 patients in the first group receiving VAC treatment by means of Y-connector and 11 patients in the second group receiving bridge-VAC treatment...
September 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28865584/bone-block-arthrodesis-procedure-in-failures-of-first-metatarsophalangeal-joint-replacement
#20
Federico Giuseppe Usuelli, Jacopo Tamini, Camilla Maccario, Miriam Grassi, Eric W Tan
BACKGROUND: The treatment for the failure of a first metatarsophalangeal joint (MTP1) prosthesis can be complex. There is no consensus regarding the ideal treatment. One of the main issues is the available bone stock after prosthesis removal. The aim of the study was to report the clinical and radiographic results for MTP1 arthrodesis with autologous calcaneus bone graft (bone-block fusion) as a revision procedure of a previous MTP1 implant failure. METHODS: This study included 12 patients diagnosed with failure of a MTP1 prosthesis...
September 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
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