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https://www.readbyqxmd.com/read/29346148/vertical-profunda-artery-perforator-flap-for-plantar-foot-wound-closure-a-new-application
#1
Allyson R Alfonso, James L Mayo, Vishal K Sharma, Robert J Allen, Ernest S Chiu
BACKGROUND: Plantar foot reconstruction requires special consideration of both form and function. There are several fasciocutaneous flap options, each with indications and reservations. CASE STUDY: This case presents a new application of the vertical profunda artery perforator flap for definitive closure of a neuropathic foot ulcer in a young woman with spina bifida. The postoperative course was uneventful, and the flap survived completely. The surgical and donor sites were without wound recurrence at 5-month follow-up...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29346146/use-of-oxidized-regenerated-cellulose-collagen-matrix-in-chronic-diabetic-foot-ulcers-a-systematic-review
#2
Gisele Chicone, Viviane Fernandes de Carvalho, André Oliveira Paggiaro
OBJECTIVE: Diabetic wounds that do not heal completely usually exhibit inflammatory markers, increased protease activity, and reduced levels of growth factors and cell count. A systematic review was performed to determine whether there is enough evidence to support the use of an oxidized regenerated cellulose/collagen matrix (ORC+C) to treat diabetic foot ulcers (DFUs). METHODS: Study authors analyzed randomized controlled trials (RCTs) on ORC+C dressings for the treatment of DFUs...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29337175/minimally-invasive-versus-extensile-lateral-approach-for-saners-type-ii-and-iii-calcaneal-fractures-a-meta-analysis-of-randomized-controlled-trials
#3
REVIEW
Zhikui Zeng, Lingmei Yuan, Shengpeng Zheng, Youqiang Sun, Feng Huang
BACKGROUND: The use of less-invasive techniques in the treatment of displaced intra-articular calcaneal fractures (DIACFs) remains controversial. No prior meta-analysis has considered the influence of differences in the fracture type. Thus, our meta-analysis aimed to investigate the efficacy and safety of minimally invasive (MI) in Sanders type II and III fractures. MATERIALS AND METHODS: A comprehensive search was performed to identify RCTs comparing MI using sinus tarsi approach (STA) or percutaneous reduction (PR) to open reduction (OR) via extensile lateral approach (ELA) from the Cochrane Library, PubMed, Embase and CNKI...
January 11, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29337168/aggressive-resection-of-congenital-lumbosacral-lipomas-in-adults-indications-techniques-and-outcomes-in-122-patients
#4
S C Bai, B Z Tao, L K Wang, X G Yu, B N Xu, A J Shang
OBJECTIVE: The authors reviewed the treatment of adult patients with congenital intraspinal lipomas with total/near-total resection and discussed their preoperative characteristics, prognostic factors and surgical outcomes. METHODS: Medical records of 122 adult patients with congenital lumbosacral lipomas undergoing total/near-total resection were systematically analyzed. The cohort was subdivided into three groups depending on symptom onset age: Group 1 (≤5 years, n = 40), Group 2 (>5 years but <18 years, n = 33), and Group 3 (>18 years, n = 49)...
January 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29336904/bypass-versus-endovascular-intervention-for-healing-ischemic-foot-wounds-secondary-to-tibial-arterial-disease
#5
Abhisekh Mohapatra, Jon C Henry, Efthimios D Avgerinos, Aureline Boitet, Rabih A Chaer, Michel S Makaroun, Steven A Leers, Eric S Hager
OBJECTIVE: Pedal (inframalleolar) bypass is a long-standing therapy for tibial arterial disease in patients with ischemic tissue loss. Endovascular tibial intervention is an appealing alternative with lower risks of perioperative mortality or complications. Our objective was to compare the effectiveness of these two treatment modalities with respect to patency and limb-related clinical outcomes. METHODS: We performed a retrospective chart review of patients presenting between 2006 and 2013 with ischemic foot wounds and infrapopliteal arterial disease who underwent a revascularization procedure (either open surgical bypass to an inframalleolar target or endovascular tibial intervention)...
January 11, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29336265/efficacy-of-aloe-vera-plantago-major-gel-in-diabetic-foot-ulcer-a-randomized-double-blind-clinical-trial
#6
Younes Najafian, Zahra Mazloum Khorasani, Mona Najaf Najafi, Shokouhsadat Hamedi, Marjan Mahjour, Zohre Feyzabadi
BACKGROUND: Diabetic foot ulcer (DFU) is one of the most common complications of diabetic patients. Mostly, non-healing DFU leads to infection, gangrene, amputation and even death. High costs and poor healing of the wounds need a new treatment such as alternative medicine. So, the aim of this study was to evaluate the efficacy of Aloe vera/ Plantago major gel (Plantavera gel) in healing of DFU. METHODS: Forty patients with DFU enrolled in a double-blind randomized clinical trial...
January 14, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29320639/minimally-invasive-distal-metatarsal-metaphyseal-osteotomy-dmmo-of-the-fifth-metatarsal-for-bunionette-correction
#7
Kar Hao Teoh, Kartik Hariharan
BACKGROUND: Different osteotomies have been proposed for the treatment of bunionette deformity. Minimally invasive surgery is now increasingly popular for a variety of forefoot conditions. The aim of this study was to evaluate the outcome following fifth minimally invasive distal metatarsal metaphyseal osteotomy (DMMO) for bunionette deformity. METHODS: Nineteen patients (21 feet) who had symptomatic bunionette deformity and failed conservative treatment between 2014 and 2016 were included in this retrospective study...
January 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29320522/do-systematic-reviews-address-community-healthcare-professionals-wound-care-uncertainties-results-from-evidence-mapping-in-wound-care
#8
Janice Christie, Trish A Gray, Jo C Dumville, Nicky A Cullum
BACKGROUND: Complex wounds such as leg and foot ulcers are common, resource intensive and have negative impacts on patients' wellbeing. Evidence-based decision-making, substantiated by high quality evidence such as from systematic reviews, is widely advocated for improving patient care and healthcare efficiency. Consequently, we set out to classify and map the extent to which up-to-date systematic reviews containing robust evidence exist for wound care uncertainties prioritised by community-based healthcare professionals...
2018: PloS One
https://www.readbyqxmd.com/read/29316701/the-effect-of-cryopreserved-human-placental-tissues-on-biofilm-formation-of-wound-associated-pathogens
#9
Yong Mao, Anya Singh-Varma, Tyler Hoffman, Sandeep Dhall, Alla Danilkovitch, Joachim Kohn
Biofilm, a community of bacteria, is tolerant to antimicrobial agents and ubiquitous in chronic wounds. In a chronic DFU (Diabetic Foot Ulcers) clinical trial, the use of a human cryopreserved viable amniotic membrane (CVAM) resulted in a high rate of wound closure and reduction of wound-related infections. Our previous study demonstrated that CVAM possesses intrinsic antimicrobial activity against a spectrum of wound-associated bacteria under planktonic culture conditions. In this study, we evaluated the effect of CVAM and cryopreserved viable umbilical tissue (CVUT) on biofilm formation of S...
January 8, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29311091/neutralizing-%C3%AE-toxin-accelerates-healing-of-staphylococcus-aureus-infected-wounds-in-normal-and-diabetic-mice
#10
Roger V Ortines, Haiyun Liu, Lily I Cheng, Taylor S Cohen, Heather Lawlor, Abhishek Gami, Yu Wang, Carly A Dillen, Nathan K Archer, Robert J Miller, Alyssa G Ashbaugh, Bret L Pinsker, Mark C Marchitto, Christine Tkaczyk, C Kendall Stover, Bret R Sellman, Lloyd S Miller
Staphylococcus aureus wound infections delay healing and result in invasive complications such as osteomyelitis, especially in the setting of diabetic foot ulcers. In preclinical animal models of S. aureus skin infection, antibody neutralization of α-toxin (AT), a S. aureus secreted pore-forming cytolytic toxin, reduces disease severity by inhibiting skin necrosis and restoring effective host immune responses. However, whether therapeutic neutralization of α-toxin is effective against S. aureus-infected wounds is unclear...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29310150/noninvasive-vascular-assessment-of-lower-extremity-wounds-in-diabetics-are-we-able-to-predict-perfusion-deficits
#11
Iram Naz, Elliot Walters, Cameron M Akbari, Christopher E Attinger, Paul J Kim
Vascular assessment of the lower extremity is a critical step in any patient presenting with lower extremity chronic wounds to predict the likelihood of healing and risk of amputation. This concept is vital in patients with diabetes due to their complex vascular anatomy and disease distribution. Three arteries supply the six angiosomes of the lower extremity (i.e., three-dimensional blocks of tissue fed by a "source" artery in the foot and ankle). In diabetic patients, assessment of adequate blood flow to the lower extremities is complicated by the presence of arterial calcification, associated neuropathy, and inflammation...
October 12, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29308553/the-assessment-of-buerger-s-exercise-on-dorsal-foot-skin-circulation-in-patients-with-vasculopathic-diabetic-foot-ulcer-by-using-wireless-near-infrared-spectroscope-a-cohort-prospective-study
#12
Bor-Shyh Lin, Chang-Cheng Chang, Chun-Lin Su, Jhe-Ruei Li, Min-Ling Chen, Mei-Yen Chen, Yao-Kuang Huang
The improvement of peripheral circulation is crucial for the care of vasculopathic diabetic foot ulcer (DFU). Near-infrared spectroscopy (NIRS) was used to investigate the effects of Buerger's exercise on dorsal foot skin circulation with novel technique of measuring the absorption difference in wavelength of light between oxy-hemoglobin (HbO2) and deoxy-hemoglobin (HbR). Patients with vasculopathic DFU who could tolerate Buerger's exercise three times a day at home for at least 8 weeks were enrolled (group A)...
January 8, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29305093/pilot-assessment-of-the-angiosome-concept-by-intra-operative-fluorescence-angiography-after-tibial-bypass-surgery
#13
Ulrich Rother, Werner Lang, Raymund E Horch, Ingo Ludolph, Alexander Meyer, Olaf Gefeller, Susanne Regus
OBJECTIVES: The "angiosome" concept as a model for decision making in revascularisation of patients with critical limb ischaemia (CLI) has been subject to lively discussion in recent years. The aim of this prospective pilot study was to use intra-operative fluorescence angiography to provide further data on the angiosome concept on the level of microcirculation after tibial bypass surgery. DESIGN, MATERIALS, AND METHODS: This was a prospective analysis of 40 patients presenting with CLI Rutherford stage IV to VI before and after tibial bypass surgery...
January 2, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29304937/an-economic-evaluation-of-the-impact-cost-and-medicare-policy-implications-of-chronic-nonhealing-wounds
#14
Samuel R Nussbaum, Marissa J Carter, Caroline E Fife, Joan DaVanzo, Randall Haught, Marcia Nusgart, Donna Cartwright
OBJECTIVE: The aim of this study was to determine the cost of chronic wound care for Medicare beneficiaries in aggregate, by wound type and by setting. METHODS: This retrospective analysis of the Medicare 5% Limited Data Set for calendar year 2014 included beneficiaries who experienced episodes of care for one or more of the following: arterial ulcers, chronic ulcers, diabetic foot ulcers, diabetic infections, pressure ulcers, skin disorders, skin infections, surgical wounds, surgical infections, traumatic wounds, venous ulcers, or venous infections...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29277539/skin-wound-healing-is-accelerated-by-a-lipid-mixture-representing-major-lipid-components-of-chamaecyparis-obtusa-plant-extract
#15
Byung Eui Kim, Elena Goleva, Clifton F Hall, Sang Hyun Park, Un Ha Lee, Anne M Brauweiler, Joanne E Streib, Brittany N Richers, Gwuicheol Kim, Donald Y M Leung
In chronic non-healing wounds, the healing process is disrupted and wounds are often infected with bacteria. About 85% of lower extremity amputations in diabetes are attributed to deep infection of foot ulcers. Therefore, infection control is critical for wound care. In this study, we analyzed lipid composition of Chamaecyparis (C) obtusa extract, and describe the wound healing properties of its combination of ten major lipid components. A 10 lipid mixture upregulated HBD-3 and LL-37 through the olfactory receptor 2AT4, and induced phosphorylation of extracellular signal-regulated kinases and p38 mitogen-activated protein kinases in primary human keratinocytes...
December 22, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29275068/sucrose-octasulfate-dressing-versus-control-dressing-in-patients-with-neuroischaemic-diabetic-foot-ulcers-explorer-an-international-multicentre-double-blind-randomised-controlled-trial
#16
Michael Edmonds, José Luis Lázaro-Martínez, Jesus Manuel Alfayate-García, Jacques Martini, Jean-Michel Petit, Gerry Rayman, Ralf Lobmann, Luigi Uccioli, Anne Sauvadet, Serge Bohbot, Jean-Charles Kerihuel, Alberto Piaggesi
BACKGROUND: Diabetic foot ulcers are serious and challenging wounds associated with high risk of infection and lower-limb amputation. Ulcers are deemed neuroischaemic if peripheral neuropathy and peripheral artery disease are both present. No satisfactory treatment for neuroischaemic ulcers currently exists, and no evidence supports one particular dressing. We aimed to assess the effect of a sucrose octasulfate dressing versus a control dressing on wound closure in patients with neuroischaemic diabetic foot ulcers...
December 20, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29273315/staphylococcus-aureus-triggers-induction-of-mir-15b-5p-to-diminish-dna-repair-and-de-regulate-inflammatory-response-in-diabetic-foot-ulcers
#17
Horacio A Ramirez, Irena Pastar, Ivan Jozic, Olivera Stojadinovic, Rivka C Stone, Nkemcho Ojeh, Joel Gil, Stephen C Davis, Robert S Kirsner, Marjana Tomic-Canic
Diabetic foot ulcers (DFUs) are a debilitating complication of diabetes in which bacterial presence, including its frequent colonizer Staphylococcus aureus, contribute to inhibition of healing. MicroRNAs (miRs) play a role in healing and host response to bacterial pathogens. However, the mechanisms by which miR response to cutaneous S. aureus contributes to DFU pathophysiology are unknown. Herein we show S. aureus inhibits wound closure and induces miR-15b-5p in acute human and porcine wound models, and in chronic DFUs...
December 19, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29273251/outcomes-and-complications-following-endoscopically-assisted-percutaneous-achilles-tendon-repair
#18
Chamnanni Rungprai, Phinit Phisitkul
PURPOSE: To review functional and clinical outcomes as well as complications in patients who underwent endoscopically assisted percutaneous Achilles tendon repair using 4-strand core suture configuration via a 6-portal technique. METHODS: A retrospective chart review with prospectively collected data was performed in 23 consecutive patients who underwent endoscopically assisted percutaneous Achilles tendon repair between 2008 and 2015. The minimum follow-up to be included in the study was 24 months...
December 19, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29261560/the-effect-of-foot-exercises-on-wound-healing-in-type-2-diabetic-patients-with-a-foot-ulcer
#19
Şahizer Eraydin, Gülçin Avşar
PURPOSE: The purpose of this study was to investigate the effect of foot exercises on wound healing in type 2 diabetic patients with a diabetic foot ulcer. DESIGN: Prospective, randomized controlled study. SUBJECT AND SETTINGS: Sixty-five patients from an outpatient clinic with grade 1 or 2 ulcers (Wagner classification) who met study criteria agreed to participate; 60 patients completed the study and were included in the final analysis. Subjects were followed up between February 2014 and June 2015...
December 19, 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/29251541/imagej-a-free-easy-and-reliable-method-to-measure-leg-ulcers-using-digital-pictures
#20
Javier Aragón-Sánchez, Yurena Quintana-Marrero, Cristina Aragón-Hernández, María José Hernández-Herero
Wound measurement to document the healing course of chronic leg ulcers has an important role in the management of these patients. Digital cameras in smartphones are readily available and easy to use, and taking pictures of wounds is becoming a routine in specialized departments. Analyzing digital pictures with appropriate software provides clinicians a quick, clean, and easy-to-use tool for measuring wound area. A set of 25 digital pictures of plain foot and leg ulcers was the basis of this study. Photographs were taken placing a ruler next to the wound in parallel with the healthy skin with the iPhone 6S (Apple Inc, Cupertino, CA), which has a camera of 12 megapixels using the flash...
December 2017: International Journal of Lower Extremity Wounds
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