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https://www.readbyqxmd.com/read/29352366/a-new-class-of-cest-experiment-based-on-selecting-different-magnetization-components-at-the-start-and-end-of-the-cest-relaxation-element-an-application-to-1h-cest
#1
Tairan Yuwen, Lewis E Kay
Chemical exchange saturation transfer (CEST) experiments are becoming increasingly popular for investigating biomolecular exchange dynamics with rates on the order of approximately 50-500 s-1 and a rich toolkit of different methods has emerged over the past few years. Typically, experiments are based on the evolution of longitudinal magnetization, or in some cases two-spin order, during a fixed CEST relaxation delay, with the same class of magnetization prepared at the start and selected at end of the CEST period...
January 19, 2018: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/29352254/author-correction-long-term-carbon-sink-in-borneo-s-forests-halted-by-drought-and-vulnerable-to-edges
#2
Lan Qie, Simon L Lewis, Martin J P Sullivan, Gabriela Lopez-Gonzalez, Georgia C Pickavance, Terry Sunderland, Peter Ashton, Wannes Hubau, Kamariah Abu Salim, Shin-Ichiro Aiba, Lindsay F Banin, Nicholas Berry, Francis Q Brearley, David F R P Burslem, Martin Dančák, Stuart J Davies, Gabriella Fredriksson, Keith C Hamer, Radim Hédl, Lip Khoon Kho, Kanehiro Kitayama, Haruni Krisnawati, Stanislav Lhota, Yadvinder Malhi, Colin Maycock, Faizah Metali, Edi Mirmanto, Laszlo Nagy, Reuben Nilus, Robert Ong, Colin A Pendry, Axel Dalberg Poulsen, Richard B Primack, Ervan Rutishauser, Ismayadi Samsoedin, Bernaulus Saragih, Plinio Sist, J W Ferry Slik, Rahayu Sukmaria Sukri, Martin Svátek, Sylvester Tan, Aiyen Tjoa, Mark van Nieuwstadt, Ronald R E Vernimmen, Ishak Yassir, Petra Susan Kidd, Muhammad Fitriadi, Nur Khalish Hafizhah Ideris, Rafizah Mat Serudin, Layla Syaznie Abdullah Lim, Muhammad Shahruney Saparudin, Oliver L Phillips
The original version of this Article contained an error in the third sentence of the abstract and incorrectly read "Here, using long-term plot monitoring records of up to half a century, we find that intact forests in Borneo gained 0.43 Mg C ha-1 year-1 (95% CI 0.14-0.72, mean period 1988-2010) above-ground live biomass", rather than the correct "Here, using long-term plot monitoring records of up to half a century, we find that intact forests in Borneo gained 0.43 Mg C ha-1 year-1 (95% CI 0.14-0.72, mean period 1988-2010) in above-ground live biomass carbon"...
January 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29352072/sex-and-race-differences-in-lifetime-risk-of-heart-failure-with-preserved-ejection-fraction-and-heart-failure-with-reduced-ejection-fraction
#3
Ambarish Pandey, Wally Omar, Colby Ayers, Michael LaMonte, Liviu Klein, Norrina Allen, Lewis H Kuller, Philip Greenland, Charles Eaton, John S Gottdiener, Donald Lloyd-Jones, Jarett D Berry
Background -Lifetime risk of heart failure has been estimated to range from 20% to 46% in diverse sex and race groups. However, lifetime risk estimates for the two HF phenotypes, HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF), is not known. Methods -Participant-level data from 2 large prospective cohort studies, the Cardiovascular Health Study (CHS) and the Multiethnic Study of Atherosclerosis (MESA), were pooled excluding individuals with prevalent HF at baseline...
January 19, 2018: Circulation
https://www.readbyqxmd.com/read/29352007/outcomes-in-anticoagulated-patients-with-atrial-fibrillation-and-with-mitral-or-aortic-valve-disease
#4
Dragos Vinereanu, Alice Wang, Hillary Mulder, Renato D Lopes, Petr Jansky, Basil S Lewis, Bernard J Gersh, Alvaro Avezum, Michael Hanna, Claes Held, Lars Wallentin, Christopher B Granger, John H Alexander
OBJECTIVE: To assess stroke/systemic embolism, major bleeding and other outcomes, and treatment effect of apixaban versus warfarin, in patients with atrial fibrillation (AF) and different types of valvular heart disease (VHD), using data from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial. METHODS: There were 14 793 patients with known VHD status, categorised as having moderate or severe mitral regurgitation (MR) (n=3382), aortic regurgitation (AR) (n=842) or aortic stenosis (AS) (n=324); patients with moderate or severe mitral stenosis were excluded from the trial...
January 19, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29351790/development-of-a-framework-to-improve-the-process-of-recruitment-to-randomised-controlled-trials-rcts-the-sear-screened-eligible-approached-randomised-framework
#5
Caroline Wilson, Leila Rooshenas, Sangeetha Paramasivan, Daisy Elliott, Marcus Jepson, Sean Strong, Alison Birtle, David J Beard, Alison Halliday, Freddie C Hamdy, Rebecca Lewis, Chris Metcalfe, Chris A Rogers, Robert C Stein, Jane M Blazeby, Jenny L Donovan
BACKGROUND: Research has shown that recruitment to trials is a process that stretches from identifying potentially eligible patients, through eligibility assessment, to obtaining informed consent. The length and complexity of this pathway means that many patients do not have the opportunity to consider participation. This article presents the development of a simple framework to document, understand and improve the process of trial recruitment. METHODS: Eight RCTs integrated a QuinteT Recruitment Intervention (QRI) into the main trial, feasibility or pilot study...
January 19, 2018: Trials
https://www.readbyqxmd.com/read/29351035/conscious-perception-of-facial-asymmetry-in-a-unilateral-cleft-lip-model
#6
Allison M Dobbie, Ralph C Ward, Samuel L Oyer, Lewis J Overton, Elizabeth G Hill, Krishna G Patel
OBJECTIVE: Lip asymmetry after a unilateral cleft lip repair can be perceived as an unsatisfactory result. The objective of this study is to determine the degree of upper lip asymmetry and/or nasal alar hooding required for recognition of asymmetry in a simulated model of unilateral cleft lip. DESIGN: A model of unilateral cleft lip was created using digital morphing software to simulate asymmetries in vermilion height and nasal hooding in photographs of children...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29350930/curtin-hammett-driven-intramolecular-cyclization-of-heteroenyne-allenes-to-phenanthridine-fused-quinazoliniminiums
#7
Pamela S Filby, Sundeep Rayat
Intramolecular cyclization of the heteroenyne-allene, 2-((biphenyl-2-ylimino)methyleneamino)benzonitrile 1 to phenanthridine-fused quinazoliniminium salt PQ in the presence of a Lewis acid at room temperature involves formation of two new bonds: a C-C bond and a C-N bond. In this article, density functional theory (B3LYP and M06-2X) was employed in conjunction with 6-311G* basis set to gain insights into the mechanism of this cyclization reaction. The solvent effects were considered using Polarizable Continuum Model with nitromethane as the solvent...
January 19, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29350564/role-of-madcam-1-expressing-high-endothelial-venule-like-vessels-in-colitis-induced-in-mice-lacking-sulfotransferases-catalyzing-l-selectin-ligand-biosynthesis
#8
Shulin Low, Jotaro Hirakawa, Hitomi Hoshino, Kenji Uchimura, Hiroto Kawashima, Motohiro Kobayashi
Ulcerative colitis (UC) is a chronic inflammatory disease histologically characterized by diffuse mononuclear cell infiltrates in colonic mucosa. These inflammatory cells are considered to be recruited via high endothelial venule (HEV)-like vessels displaying mucosal addressin cell adhesion molecule 1 (MAdCAM-1), the ligand for α4β7 integrin, and/or peripheral lymph node addressin (PNAd), an L-selectin ligand. 6- O-sulfation of N-acetylglucosamine in the carbohydrate moiety of PNAd is catalyzed exclusively by N-acetylglucosamine-6- O-sulfotransferase 1 (GlcNAc6ST-1) and GlcNAc6ST-2...
January 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29350523/amphiphilic-%C3%AF-allyliridium-c-o-benzoates-enable-regio-and-enantioselective-amination-of-branched-allylic-acetates-bearing-linear-alkyl-groups
#9
Arismel Tena Meza, Thomas Wurm, Lewis Smith, Seung Wook Kim, Jason R Zbieg, Craig E Stivala, Michael J Krische
The first examples of amphiphilic reactivity in the context of enantioselective catalysis are described. Commercially available π-allyliridium C,O-benzoates, which are stable to air, water and SiO2 chromatography, and are well-known to catalyze allyl acetate-mediated carbonyl allylation, are now shown to catalyze highly chemo-, regio- and enantioselective substitutions of branched allylic acetates bearing linear alkyl groups with primary amines.
January 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29350313/immobilization-of-methylosinus-trichosporium-ob3b-for-methanol-production
#10
Anne Taylor, Paige Molzahn, Tanner Bushnell, Clint Cheney, Monique LaJeunesse, Mohamad Azizian, Lewis Semprini
Due to the natural gas boom in North America, there is renewed interest in the production of other chemical products from methane. We investigated the feasibility of immobilizing the obligate methanotrophic bacterium Methylosinus trichosporium OB3b in alginate beads, and selectively inactivating methanol dehydrogenase (MDH) with cyclopropane to produce methanol. In batch cultures and in semi-continuous flow columns, the exposure of alginate-immobilized cells to cyclopropane or cyclopropanol resulted in the loss of the majority of MDH activity (> 80%), allowing methanol to accumulate to significant concentrations while retaining all of M...
January 19, 2018: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29350301/constipation-in-parkinson-s-disease-a-nuisance-or-nuanced-answer-to-the-pathophysiological-puzzle
#11
REVIEW
Amol Sharma, Julie Kurek, John C Morgan, Chandramohan Wakade, Satish S C Rao
PURPOSE OF REVIEW: Chronic constipation is a common, nonmotor, and prodromal symptom in Parkinson's disease (PD). Its underlying neuropathology may provide pathophysiological insight into PD. Here, we critically review what is currently known about the neuroanatomical and brain-gut interactions, and the origin and progression of Lewy pathology (LP) at three levels-brain/brainstem, spinal cord, and enteric nervous system. RECENT FINDINGS: Many recent studies have illustrated the challenges of examining LP in tissues obtained from colon biopsies of PD patients...
January 19, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29350191/a-prospective-gating-method-to-acquire-a-diverse-set-of-free-breathing-ct-images-for-model-based-4dct
#12
Dylan O'Connell, Dan Ruan, David H Thomas, Tai H Dou, John H Lewis, Anand P Santhanam, Percy P Lee, Daniel A Low
Breathing motion modeling requires observation of tissues at sufficiently distinct respiratory states for proper 4D characterization. This work proposes a method to improve sampling of the breathing cycle with limited imaging dose. We designed and tested a prospective free-breathing acquisition protocol with a simulation using datasets from 5 patients imaged with a model-based 4DCT technique. Each dataset contained 25 free-breathing fast helical CT scans with simultaneous breathing surrogate measurements...
January 19, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29350043/the-acid-free-cyclopropanol-minisci-reaction-reveals-the-catalytic-role-of-silver-pyridine-complexes
#13
Andrei Nikolaev, Claude Y Legault, Minhao Zhang, Arturo Orellana
A well-defined homogeneous silver precatalyst can be utilized for the direct C-H functionalization of a wide range of aromatic nitrogen heterocycles with cyclopropanols under acid-free conditions. This reaction can be conducted on gram-scale and with low catalyst loadings (as low as 1%), which is rare for silver-catalyzed Minisci-type reactions. Moreover, reactivity trends, as well as steric and calculated electronic properties of the heterocycles, strongly suggest that silver-heterocycle complexes formed in situ behave as redox active catalysts and as Lewis acid activators of the heterocycle and that the electronic nature of the heterocyclic substrates tunes the reactivity of the resulting complexes...
January 19, 2018: Organic Letters
https://www.readbyqxmd.com/read/29350023/erratum-to-plasma-betaine-concentrations-correlate-with-plasma-cortisol-but-not-with-c-reactive-protein-in-an-elderly-population
#14
Michael Lever, Malina K. Storer, John G. Lewis, Peter M. George, Stephen T. Chambers
No abstract text is available yet for this article.
September 12, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29349566/performance-improvement-in-head-and-neck-cancer
#15
REVIEW
Carol M Lewis, Randal S Weber
Performance improvement requires establishing a platform to set benchmarks and monitor the quality of care provided through quality indicators and metrics. This has long been recognized as critical to overall quality improvement and more recently, has become federally mandated. Here, we review recent studies evaluating performance in head and neck cancer care, from those spanning all phases of head and neck cancer care to others focused on head and neck surgical performance, including both national and departmental/institutional efforts...
January 19, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29349556/neuropathology-correlates-of-cognitive-assessments
#16
Francesca M Brett, Hugh Kearney
BACKGROUND: Alzheimer's disease and other dementias are the fourth largest contributors to neurological disability and the second largest contributor to deaths from neurological disease. Described in the 1980s as 'the silent epidemic' these disorders principally, though not exclusively, affect persons 80 years or older, and in developed countries, this 'old old' population continues to grow. Definitive diagnosis of the underlying cause of the neurodegenerative disease relies on neuropathological evaluation...
January 18, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29349099/repetitive-questioning-exasperates-caregivers
#17
R C Hamdy, J V Lewis, R Copeland, A Depelteau, A Kinser, T Kendall-Wilson, K Whalen
Repetitive questioning is due to an impaired episodic memory and is a frequent, often presenting, problem in patients with Alzheimer's disease (amnestic type). It is due to the patients' difficulties learning new information, retaining it, and recalling it, and is often aggravated by a poor attention span and easy distractibility. A number of factors may trigger and maintain repetitive questioning. Caregivers should try to identify and address these triggers. In the case discussion presented, it is due to the patient's concerns about her and her family's safety triggered by watching a particularly violent movie aired on TV...
January 2018: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29348667/neuroimmunology-brain-police
#18
Sian Lewis
No abstract text is available yet for this article.
January 19, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29348590/the-theoretical-molecular-weight-of-nayf-4-re-upconversion-nanoparticles
#19
Lewis E Mackenzie, Jack A Goode, Alexandre Vakurov, Padmaja P Nampi, Sikha Saha, Gin Jose, Paul A Millner
Upconversion nanoparticles (UCNPs) are utilized extensively for biomedical imaging, sensing, and therapeutic applications, yet the molecular weight of UCNPs has not previously been reported. Herein, we present a theory based upon the crystal structure of UCNPs to estimate the molecular weight of UCNPs: enabling insight into UCNP molecular weight for the first time. We estimate the theoretical molecular weight of various UCNPs reported in the literature, predicting that spherical NaYF4 UCNPs ~ 10 nm in diameter will be ~1 MDa (i...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348251/reducing-cardiovascular-disparities-through-community-engaged-implementation-research-a-national-heart-lung-and-blood-institute-workshop-report
#20
George A Mensah, Richard S Cooper, Anna Maria Siega-Riz, Lisa A Cooper, Justin D Smith, C Hendricks Brown, John M Westfall, Elizabeth O Ofili, LeShawndra N Price, Sonia Arteaga, Melissa C Green Parker, Cheryl R Nelson, Bradley J Newsome, Nicole Redmond, Rebecca A Roper, Bettina M Beech, Jada L Brooks, Debra Furr-Holden, Samson Y Gebreab, Wayne H Giles, Regina Smith James, Tené T Lewis, Ali H Mokdad, Kari D Moore, Joseph E Ravenell, Al Richmond, Nancy E Schoenberg, Mario Sims, Gopal K Singh, Anne E Sumner, Roberto P Treviño, Karriem S Watson, M Larissa Avilés-Santa, Jared P Reis, Charlotte A Pratt, Michael M Engelgau, David C Goff, Eliseo J Pérez-Stable
Cardiovascular disparities remain pervasive in the United States. Unequal disease burden is evident among population groups based on sex, race, ethnicity, socioeconomic status, educational attainment, nativity, or geography. Despite the significant declines in cardiovascular disease mortality rates in all demographic groups during the last 50 years, large disparities remain by sex, race, ethnicity, and geography. Recent data from modeling studies, linked micromap plots, and small-area analyses also demonstrate prominent variation in cardiovascular disease mortality rates across states and counties, with an especially high disease burden in the southeastern United States and Appalachia...
January 19, 2018: Circulation Research
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