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https://www.readbyqxmd.com/read/28109097/-mucosal-healing-in-different-intestinal-segments-in-patients-receiving-infliximab-treatment-for-small-bowel-crohn-s-disease
#1
Zhen-Hao Zhu, Chen Qiu, Ming Zhang, Zhao Chen, Cheng Xiang, Xin-Ying Wang
OBJECTIVE: To evaluate the mucosal healing in the terminal ileum, colon and small bowel in patients receiving infliximab treatment for small bowel Crohn's disease (SBCD). METHODS: The clinical data of 18 patients with SBCD treated with infliximab were analyzed for laboratory findings (routine blood tests, C-reative protein, and albumin), Crohn's disease activity index (CDAI), Lewis score (LS), Crohn's disease simplified endoscopic score (SES-CD) and adverse effects before and after 30 weeks of infliximab treatment...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28108931/systematic-review-and-meta-analysis-of-surgicaltreatment-of-non-zenker-s-oesophageal-diverticula
#2
David S Y Chan, Antonio Foliaki, Wyn G Lewis, Geoffrey W B Clark, Guy R J C Blackshaw
BACKGROUND: Oesophageal diverticula are rare outpouchings of the oesophagus which may be classified anatomically as pharyngeal (Zenker's), mid-oesophageal and epiphrenic. While surgery is indicated for symptomatic patients, no consensus exists regarding the optimum technique for non-Zenker's oesophageal diverticula. The aim of this study was to determine the outcome of surgery in patients with non-Zenker's oesophageal diverticula. METHODS: PubMed, MEDLINE and the Cochrane Library (January 1990 to January 2016) were searched for studies which reported outcomes of surgery in patients with non-Zenker's oesophageal diverticula...
January 20, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28108648/reduced-firing-rates-of-high-threshold-motor-units-in-response-to-eccentric-overload
#3
Tom G Balshaw, Madhu Pahar, Ross Chesham, Lewis J Macgregor, Angus M Hunter
Acute responses of motor units were investigated during submaximal voluntary isometric tasks following eccentric overload (EO) and constant load (CL) knee extension resistance exercise. Ten healthy resistance-trained participants performed four experimental test sessions separated by 5 days over a 20 day period. Two sessions involved constant load and the other two used eccentric overload. EO and CL used both sessions for different target knee eccentric extension phases; one at 2 sec and the other at 4 sec...
January 2017: Physiological Reports
https://www.readbyqxmd.com/read/28108402/using-pharmacokinetic-modelling-to-improve-prescribing-practices-of-intravenous-aminophylline-in-childhood-asthma-exacerbations
#4
Lewis Cooney, Antonia McBride, Andrew Lilley, Ian Sinha, Trevor N Johnson, Daniel B Hawcutt
OBJECTIVE: To evaluate physiologically based pharmacokinetic modelling (PBPK) software in paediatric asthma patients using intravenous aminophylline. METHODS: Prospective clinical audit of children receiving iv aminophylline (July 2014 to June 2016), and in-silico modelling using Simcyp software. RESULTS: Thirty-eight admissions (25 children) were included. Children with aminophylline levels ≥10 mg/l had equivalent clinical outcomes compared to those <10 mg/L, and adverse effects occurred in 57%...
January 17, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28107996/the-stability-of-tnt-rdx-and-petn-in-simulated-post-explosion-soils-implications-of-sample-preparation-for-analysis
#5
H A Yu, D A DeTata, S W Lewis, N Nic Daeid
Explosives residues in soils may be a useful source of evidence following the detonation of an improvised explosive device (IED), such as a vehicle-borne IED. Soil samples collected from the vicinity of an explosion scene will often be stored for some time prior to analysis, yet explosives residues in soil samples are susceptible to rapid degradation or transformation. Although some research has assessed the use of different storage temperatures with a view to reducing explosives' degradation over time, further research examining the degradation of explosives in soil when stored under a variety of storage conditions is crucial to determine the optimal sample collection and storage procedures for soil containing explosives residues...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107621/a-molecular-dynamics-study-of-water-flow-across-multiple-layers-of-pristine-oxidized-and-mixed-regions-of-graphene-oxide
#6
Jon Alexander Lewis Willcox, Hyung J Kim
A molecular dynamics graphene oxide model is used to shed light on commonly overlooked features of graphene oxide membranes. The model features both perpendicular and parallel water flow across multiple sheets of pristine and/or oxidized graphene to simulate "brick-and-mortar" microstructures. Additionally, regions of pristine/oxidized graphene overlap which have thus far been overlooked in the literature are explored. Differences in orientational and hydrogen-bonding features between adjacent layers of water in this mixed region are found to be even more prominent than differences between pristine and oxidized channels...
January 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28107522/correction-novel-igg-degrading-enzymes-of-the-igde-protease-family-link-substrate-specificity-to-host-tropism-of-streptococcus-species
#7
Christian Spoerry, Pontus Hessle, Melanie J Lewis, Lois Paton, Jenny M Woof, Ulrich von Pawel-Rammingen
[This corrects the article DOI: 10.1371/journal.pone.0164809.].
2017: PloS One
https://www.readbyqxmd.com/read/28107356/integrity-of-induced-pluripotent-stem-cell-ipsc-derived-megakaryocytes-as-assessed-by-genetic-and-transcriptomic-analysis
#8
Kai Kammers, Margaret A Taub, Ingo Ruczinski, Joshua Martin, Lisa R Yanek, Alyssa Frazee, Yongxing Gao, Dixie Hoyle, Nauder Faraday, Diane M Becker, Linzhao Cheng, Zack Z Wang, Jeff T Leek, Lewis C Becker, Rasika A Mathias
Previously, we have described our feeder-free, xeno-free approach to generate megakaryocytes (MKs) in culture from human induced pluripotent stem cells (iPSCs). Here, we focus specifically on the integrity of these MKs using: (1) genotype discordance between parent cell DNA to iPSC cell DNA and onward to the differentiated MK DNA; (2) genomic structural integrity using copy number variation (CNV); and (3) transcriptomic signatures of the derived MK lines compared to the iPSC lines. We detected a very low rate of genotype discordance; estimates were 0...
2017: PloS One
https://www.readbyqxmd.com/read/28107309/-delay-to-operating-room-fails-to-identify-adverse-outcomes-at-a-level-i-trauma-center
#9
Paul R Lewis, Jayraan Badiee, Michael J Sise, Richard Y Calvo, Jason B Brill, James D Wallace, Steven R Shackford, Casey E Dunne, Vishal Bansal, C Beth Sise
BACKGROUND: The American College of Surgeons Committee on Trauma devised process audit filters to identify opportunities for improvement (OFI), prevent adverse outcomes, and improve quality. Delay to the operating room for primary trauma laparotomy is a process audit filter that has not been definitively associated with improved outcomes. We sought to evaluate the effectiveness of delay to the operating room of greater than 2 hours (DOR) to independently identify an adverse outcome or an OFI at our Level I trauma center...
February 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28106984/pore-space-partition-in-metal-organic-frameworks
#10
Quan-Guo Zhai, Xianhui Bu, Xiang Zhao, Dong-Sheng Li, Pingyun Feng
Metal-organic framework (MOF) materials have emerged as one of the favorite crystalline porous materials (CPM) because of their compositional and geometric tunability and many possible applications. In efforts to develop better MOFs for gas storage and separation, a number of strategies including creation of open metal sites and implantation of Lewis base sites have been used to tune host-guest interactions. In addition to these chemical factors, the geometric features such as pore size and shape, surface area, and pore volume also play important roles in sorption energetics and uptake capacity...
January 20, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28106948/genetic-differentiation-associated-with-host-plants-and-geography-among-six-widespread-species-of-south-american-blepharoneura-fruit-flies-tephritidae
#11
Kristina Ottens, Isaac S Winkler, Matthew L Lewis, Sonja J Scheffer, Géssica A Gomes-Costa, Marty A Condon, Andrew A Forbes
Tropical herbivorous insects are astonishingly diverse and many are highly host-specific. Much evidence suggests that herbivorous insect diversity is a function of host-plant diversity; yet, the diversity of some lineages exceeds the diversity of plants. Although most species of herbivorous fruit flies in the Neotropical genus Blepharoneura are strongly host-specific (they deposit their eggs in a single host plant species and flower sex), some species are collected from multiple hosts or flowers and these may represent examples of lineages that are diversifying via changes in host use...
January 20, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28106662/medication-adherence-interventions-among-hypertensive-black-adults-a-systematic-review-and-meta-analysis
#12
Todd M Ruppar, Jacqueline M Dunbar-Jacob, David R Mehr, Lisa Lewis, Vicki S Conn
BACKGROUND: Black adults have higher rates of hypertension and lower rates of blood pressure (BP) control than white adults. Improving BP control requires attention to use of antihypertensive medications, but antihypertensive regimen adherence remains low, preventing improved BP control. METHODS AND RESULTS: We conducted a comprehensive search and systematic review of intervention studies testing interventions to improve adherence to BP medications among black adults with hypertension...
January 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28106519/subunit-mass-analysis-for-monitoring-antibody-oxidation
#13
Izabela Sokolowska, Jingjie Mo, Jia Dong, Michael J Lewis, Ping Hu
Methionine oxidation is a common posttranslational modification (PTM) of monoclonal antibodies (mAbs). Oxidation can reduce the in-vivo half-life, efficacy and stability of the product. Peptide mapping is commonly used to monitor the levels of oxidation, but this is a relatively time-consuming method. A high-throughput, automated subunit mass analysis method was developed to monitor antibody methionine oxidation. In this method, samples were treated with IdeS, EndoS and dithiothreitol to generate three individual IgG subunits (light chain, Fd' and single chain Fc)...
January 20, 2017: MAbs
https://www.readbyqxmd.com/read/28106468/proceedings-of-bmres-altitude-medicine-conference-november-26th-2016-birmingham-united-kingdom
#14
Lauren E Gault, Christopher T Lewis, Hannah E Lock
No abstract text is available yet for this article.
January 20, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28106403/lewis-acid-promoted-oxonium-ion-driven-carboamination-of-alkynes-for-the-synthesis-of-4-alkoxy-quinolines
#15
Santosh J Gharpure, Santosh Kumar Nanda, Priyanka Adhikarao Adate, Yogesh Gangaram Shelke
Lewis acid mediated multisegment coupling cascade is designed for the synthesis of densely substituted 4-alkoxy quinolines via an oxonium ion triggered alkyne carboamination sequence involving C-C and C-N bond formations. Cyclic ether fused-quinolines could also be accessed using this fast, operationally simple, high yielding, chemoselective and functional group tolerant method. Versatility and utility of this methodology is demonstrated by post functionalization of products obtained and its use in synthesis of potent drug molecules...
January 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28106384/highly-atroposelective-synthesis-of-arylpyrroles-by-catalytic-asymmetric-paal-knorr-reaction
#16
Lei Zhang, Jian Zhang, Ji Ma, Dao-Juan Cheng, Bin Tan
A general and efficient method for accessing enantiomerically pure arylpyrroles by utilizing the catalytic asymmetric Paal-Knorr reaction has been developed for the first time. A wide range of axially chiral arylpyrroles were obtained in high yields with good to excellent enantioselectivities. The key to success is the use of the combined-acid catalytic system involving a Lewis acid and a chiral phosphoric acid for achieving effective enantiocontrol. Noteworthy is that an unexpected solvent-dependent inversion of the enantioselectivity was observed in the above-mentioned asymmetric reaction...
January 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28106345/blood-based-detection-of-ras-mutations-to-guide-anti-egfr-therapy-in-colorectal-cancer-patients-concordance-of-results-from-circulating-tumor-dna-and-tissue-based-ras-testing
#17
Wolff Schmiegel, Rodney J Scott, Susan Dooley, Wendy Lewis, Cliff J Meldrum, Peter Pockney, Brian Draganic, Steve Smith, Chelsee Hewitt, Hazel Philimore, Amanda Lucas, Elva Shi, Kateh Namdarian, Timmy Chan, Danilo Acosta, Su Ping-Chang, Andrea Tannapfel, Anke Reinacher-Schick, Waldemar Uhl, Christian Teschendorf, Heiner Wolters, Josef Stern, Richard Viebahn, Helmut Friess, Klaus-Peter Janssen, Ulrich Nitsche, Julia Slotta-Huspenina, Michael Pohl, Deepak Vangala, Alexander Baraniskin, Barbara Dockhorn-Dworniczak, Susanne Hegewisch-Becker, Philippe Ronga, Daniel L Edelstein, Frederick S Jones, Stephan Hahn, Stephen B Fox
An accurate blood-based RAS mutation assay to determine eligibility of metastatic colorectal cancer (mCRC) patients for anti-EGFR therapy would benefit clinical practice by better informing decisions to administer treatment independent of tissue availability. The objective of this study was to determine the level of concordance between plasma and tissue RAS mutation status in patients with mCRC to gauge whether blood-based RAS mutation testing is a viable alternative to standard-of-care RAS tumor testing. RAS testing was performed on plasma samples from newly diagnosed metastatic patients, or from recurrent mCRC patients using the highly sensitive digital PCR technology, BEAMing (beads, emulsions, amplification, and magnetics), and compared with DNA sequencing data of respective FFPE (formalin-fixed paraffin-embedded) tumor samples...
November 16, 2016: Molecular Oncology
https://www.readbyqxmd.com/read/28106342/electrochemical-reduction-of-oxygen-in-aprotic-ionic-liquids-containing-metal-cations-na-o2-system-case-study
#18
Eneko Azaceta, Lukas Lutz, Alexis Grimaud, Jose Manuel Vicent-Luna, Said Hamad, Luis Yate, Geman Cabañero, Hans-Jurgen Grande, Juan Antonio Anta, Jean-Marie Tarascon, Ramon Tena-Zaera
Metal-air batteries are intensively studied because of their high theoretical energy storage capability. However, the fundamental science at work dealing with electrodes, electrolytes and reaction products still need to be better understood. In this report, the ionic liquid N-butyl-N-methylpyrrolidinium bis(trifluoromethanesulfonyl) imide (PYR14TFSI) is chosen to study the influence of a wide range of metal cations (Mn+) on the electrochemical behavior of oxygen.. We demonstrate the relevance of the Lewis hard-soft acid-base (HSAB) theory to predict satisfactorily the reduction potential of the oxygen reduction in electrolytes containing metal cations...
January 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28106306/acupuncture-and-electro-acupuncture-for-people-diagnosed-with-subacromial-pain-syndrome-a-multicentre-randomized-trial
#19
J Lewis, J Sim, P Barlas
BACKGROUND: Musculoskeletal disorders have been identified globally as the second most common healthcare problem for 'years lived with disability', and of these shoulder conditions are amongst the most common, frequently associated with substantial pain and morbidity. Exercise and acupuncture are often provided as initial treatments for musculoskeletal shoulder conditions but their clinical effectiveness is uncertain. This study compared group exercise with group exercise plus either acupuncture or electro-acupuncture in patients with subacromial pain syndrome...
January 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28106199/fluoride-complexation-by-bidentate-silicon-lewis-acids
#20
Jan Horstmann, Mark Niemann, Katarína Berthold, Andreas Mix, Beate Neumann, Hans-Georg Stammler, Norbert W Mitzel
Diethynyldiphenylsilane (1) and divinyldiphenylsilane (2) were functionalized by hydrosilylation reactions with HSiMe2Cl, HSiMeCl2 and HSiCl3. Fluorination of the resulting compounds generates bidentate open-chain Lewis acids of increasing acidity. All semi-flexible [Ph2Si(CH[double bond, length as m-dash]CHSiFnMe3-n)2 (n = 1, 2, 3)] and flexible [Ph2Si(CH2-CH2SiFnMe3-n)2 (n = 1, 2, 3)] bidentate Lewis acids were obtained in good to excellent yields. The different fluoride ion complexation behavior was explored in detail by multinuclear (low temperature) NMR spectroscopy...
January 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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