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https://www.readbyqxmd.com/read/29474283/face-female-pelvic-medicine-and-reconstructive-surgery-awareness-campaign-increasing-exposure
#1
Susan A Barr, Catrina C Crisp, Amanda B White, Shazia A Malik, Kimberly Kenton
OBJECTIVE: The aims of this study are to identify screening, treatment, and referral practices of primary care physicians (PCPs) for patients with pelvic floor disorders (PFDs) and evaluate awareness of the Female Pelvic Medicine and Reconstructive Surgery (FPMRS) subspecialty. METHODS: We conducted a cross-sectional survey of PCPs using a random sample of 1005 American College of Physicians members, stratified by demographic region. Electronic survey content included awareness of FPMRS certification, comfort diagnosing and treating PFDs, and PFD referral patterns for PCPs...
March 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29473934/absence-of-tert-promoter-mutations-in-colorectal-precursor-lesions-and-cancer
#2
Adriana Cruvinel-Carloni, Letícia Yamane, Cristovam Scapulatempo-Neto, Denise Guimarães, Rui Manuel Reis
Hotspot mutations (c.-124bp G > A and c.-146bp G > A) in the promoter region of the TERT gene have been recently described in several types of solid tumors, including glioma, bladder, thyroid, liver and skin neoplasms. However, knowledge with respect to colorectal precursor lesions and cancer is scarce. In the present study we aimed to determine the frequency of hotspot TERT promoter mutations in 145 Brazilian patients, including 103 subjects with precursor lesions and 42 with colorectal carcinomas, and we associated the presence of such mutations with the patients clinical-pathological features...
February 19, 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29473453/wilhelm-fabricius-von-hilden-1560-1634-the-pioneer-of-german-surgery
#3
Konstantinos Laios
Wilhelm Fabricius von Hilden (1560-1634) or also known with his Latinized name Guilielmus Fabricius Hildanus is considered the founder of scientific German surgery. He introduced new surgical techniques and invented new surgical instruments for the surgical treatment of nasal polyps, stone bladder, breast and ocular cancer, hydrocele, and ascites, while very ingenious were his amputation techniques. His most important surgical treatise was Observationem et curationem chirurgicam centuriae sex ( Six Hundred Surgical Observations and Treatments) first published in 1606...
February 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29473387/elderly-patient-with-atypical-leiomyoma-of-the-bladder-presenting-as-flank-pain-a-case-report
#4
Mojtaba Ameli, Mina Rahmandoost
Atypical leiomyoma is a rare tumor of the bladder whose correct diagnosis with imaging techniques and cystoscopy is difficult. This tumor is prevalent in females and more common in middle age. In the present study we report a rare case of atypical leiomyoma presenting as flank pain and history of recurrent urinary tract infections in an elderly female. Ultrasound (US) showed that the wall of bladder was thickening and irregular, especially in the lower part of the bladder. US revealed hypoechoic solid mass with dimensions of 37 x 26 mm in the posterior bladder wall protruding into the bladder...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473382/a-randomized-multicenter-controlled-study-comparing-efficacy-and-safety-of-a-new-complementary-and-alternative-medicine-cam-versus-solifenacin-succinate-in-women-with-overactive-bladder-syndrome
#5
Carlo Vecchioli-Scaldazza, Carolina Morosetti, Serena Maruccia, Stefano Casellato, Wilma Rociola, Ester Illiano, Francesco Garofalo
INTRODUCTION: To assess efficacy and tolerability of a new complementary and alternative medicine (CAM) consisting of vitamins (C and D), herbal products (cucurbita maxima, capsicum annum, polygonum capsicatum) and amino acid L-Glutammina, in the treatment of female Overactive Bladder syndrome (OAB). MATERIALS AND METHODS: 90 consecutive women with OAB symptoms were enrolled in this prospective, randomized, controlled study. Women were divided randomly into two groups of 45 patients each...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473376/can-re-cturbt-be-useful-in-pt1hg-disease-as-a-risk-indicator-of-recurrence-and-progression-a-single-centre-experience
#6
Roberto Giulianelli, Barbara Cristina Gentile, Gabriella Mirabile, Luca Albanesi, Paola Tariciotti, Giorgio Rizzo, Maurizio Buscarini, Mauro Vermiglio
INTRODUCTION: Understaging after initial transurethral resection is common in patients with high-risk non muscle infiltrating bladder cancer (NMIBC) and can delay accurate diagnosis and definitive treatment. The rate of upstaging from T1 to T2 disease after repeated transurethral resection ranges from 0 to 28%, although the rate of upstaging may be even higher up to 49% when muscularis propria is absent in the first specimen. A restaging classic transurethral resection of bladder tumour (re-cTURBT) is the better predictor of early stage progression...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29473339/feeling-of-incomplete-emptying-with-little-post-void-residual-in-patients-with-lower-urinary-tract-symptoms-clinical-implications-and-treatment-outcomes
#7
Minoru Kobayashi, Yuumi Tokura, Tsunehito Kambara, Akinori Nukui, Takao Kamai
OBJECTIVE: The aim of the present study was to examine the clinical features and implications of a feeling of incomplete emptying despite little post-void residual (PVR), because it remains unclear why patients are bothered by such an undefined feeling. METHODS: Data were collected prospectively from 173 consecutive patients (135 men, 38 women) with a complaint of a feeling of incomplete emptying with PVR <50 mL at an initial visit. The International Prostate Symptom Score (IPSS), quality of life (QoL) score, overactive bladder symptom score (OABSS), prostate volume, and PVR were determined...
February 22, 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29473309/efficacy-of-mirabegron-for-overactive-bladder-with-human-t-cell-lymphotropic-virus-1-associated-myelopathy
#8
Tomohiro Matsuo, Yasuyoshi Miyata, Tatsufumi Nakamura, Katsuya Satoh, Hideki Sakai
OBJECTIVE: Mirabegron is widely considered as an effective and safe drug for patients with overactive bladder (OAB). However, there is no evidence regarding the efficacy of mirabegron in human T cell lymphotropic virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients with OAB symptoms. The aim of the present study was to clarify the efficacy of mirabegron in HAM/TSP patients with OAB symptoms. METHODS: The present study evaluated the efficacy of mirabegron treatment (50 mg, once daily) in nineteen HAM/TSP patients with OAB symptoms by assessing subjective symptoms using the overactive bladder symptom score (OABSS) and International Prostate Symptom Score (IPSS) before and 12 weeks after administration...
February 22, 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29473226/infiltrative-lamina-propria-invasion-pattern-as-an-independent-predictor-for-cancer-specific-and-overall-survival-of-instillation-treatment-na%C3%A3-ve-stage-t1-high-grade-urothelial-bladder-cancer
#9
Wolfgang Otto, Bas Wg van Rhijn, Johannes Breyer, Simone Bertz, Markus Eckstein, Roman Mayr, Eva M Lausenmeyer, Stefan Denzinger, Maximilian Burger, Arndt Hartmann
OBJECTIVES: To investigate established prognostic factors and relatively new histopathological tumor characteristics including metric substage and lamina propria invasion patterns in a large series of T1 high-grade non-muscle-invasive bladder cancer. METHODS: Between 1989 and 2012, 322 patients with initial stage T1 high-grade bladder cancer underwent transurethral resection, followed by re-transurethral resection and a conservative approach with follow-up regime alone or instillation treatment...
February 22, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29473047/familial-monophasic-acute-transverse-myelitis-due-to-the-pathogenic-variant-in-vps37a
#10
Maureen A Mealy, Tai-Seung Nam, Santiago J Pardo, Carlos A Pardo, Nara L Sobreira, Dimitrios Avramopoulos, David Valle, Kathleen H Burns, Michael Levy
Objective: To identify genetic differences among siblings with a family history of idiopathic transverse myelitis (ITM). Methods: We compared whole-exome sequencing (WES) on germline samples from the 2 affected sisters with ITM with 3 of their healthy siblings. Results: The 2 sisters with ITM both had acute onset of sensory loss in the legs, weakness, and bowel/bladder dysfunction. The first developed ITM at age 15 years with a clinical nadir of complete paralysis, which slowly recovered over a few years...
February 2018: Neurology. Genetics
https://www.readbyqxmd.com/read/29472622/aberrant-methylated-key-genes-of-methyl-group-metabolism-within-the-molecular-etiology-of-urothelial-carcinogenesis
#11
Lars Erichsen, Foued Ghanjati, Agnes Beermann, Cedric Poyet, Thomas Hermanns, Wolfgang A Schulz, Hans-Helge Seifert, Peter J Wild, Lorenz Buser, Alexander Kröning, Stefan Braunstein, Martin Anlauf, Silvia Jankowiak, Mohamed Hassan, Marcelo L Bendhack, Marcos-Arauzo Bravo, Simeon Santourlidis
Urothelial carcinoma (UC), the most common cancer of the urinary bladder causes severe morbidity and mortality, e.g. about 40.000 deaths in the EU annually, and incurs considerable costs for the health system due to the need for prolonged treatments and long-term monitoring. Extensive aberrant  DNA methylation is described to prevail in urothelial carcinoma and is thought to contribute to genetic instability, altered gene expression and tumor progression. However, it is unknown how this epigenetic alteration arises during carcinogenesis...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29472607/cell-transplantation-and-clinical-reality-kuwait-experience-in-persons-with-spinal-cord-injury
#12
S Al Kandari, L Prasad, M Al Kandari, U Ramachandran, A Krassioukov
STUDY DESIGN: Retrospective observational. OBJECTIVES: To compare objective (neurological examination) and subjective (patients perception) recovery in patients with spinal cord injury (SCI) who chose to undergo cell transplantation therapies (CTT) outside of clinical trials abroad. SETTING: Physical Medicine and Rehabilitation Hospital, Kuwait. METHODS: Nine patients with SCI who had undergone CTT outside Kuwait were identified and their neurological pre-transplantation evaluation according the International Standards for Neurological Classification of SCI (ISNCSCI) was collected from hospital records...
February 22, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29472240/clinical-factors-predict-atezolizumab-response
#13
(no author information available yet)
Researchers have presented a new model that uses six readily available clinical factors to predict whether a patient with advanced bladder cancer who has already received platinum chemotherapy will respond to treatment with the PD-L1 inhibitor atezolizumab. The results may help patients and their doctors decide how to proceed with treatment.
February 22, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29472156/novel-biomarkers-in-bladder-cancer
#14
REVIEW
Michael L Cheng, Gopa Iyer
A sea change has occurred in the treatment options available for metastatic urothelial bladder cancer with the recent Food and Drug Administration approval of 5 immune checkpoint blockade agents for patients who have progressed on platinum-based chemotherapy or are not candidates for cisplatin. Additionally, comprehensive characterization of the landscape of genomic alterations in this disease through The Cancer Genome Atlas and other efforts has detected numerous potential targets for small molecule inhibitors...
February 19, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29472097/the-influence-of-the-image-registration-method-on-the-adaptive-radiotherapy-a-proof-of-the-principle-in-a-selected-case-of-prostate-imrt
#15
Roberto Berenguer, Victoria de la Vara, Veronica Lopez-Honrubia, Ana Teresa Nuñez, Miguel Rivera, Maria Victoria Villas, Sebastia Sabater
PURPOSE: To analyse the influence of the image registration method on the adaptive radiotherapy of an IMRT prostate treatment, and to compare the dose accumulation according to 3 different image registration methods with the planned dose. MATERIAL AND METHODS: The IMRT prostate patient was CT imaged 3 times throughout his treatment. The prostate, PTV, rectum and bladder were segmented on each CT. A Rigid, a deformable (DIR) B-spline and a DIR with landmarks registration algorithms were employed...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29472083/quantifying-the-performance-of-two-different-types-of-commercial-software-programs-for-3d-patient-dose-reconstruction-for-prostate-cancer-patients-machine-log-files-vs-machine-log-files-with-epid-images
#16
Noriyuki Kadoya, Yoshio Kon, Yoshiki Takayama, Takuya Matsumoto, Naoki Hayashi, Yoshiyuki Katsuta, Kengo Ito, Takahito Chiba, Suguru Dobashi, Ken Takeda, Keiichi Jingu
We clarified the reconstructed 3D dose difference between two different commercial software programs (Mobius3D v2.0 and PerFRACTION v1.6.4). Five prostate cancer patients treated with IMRT (74 Gy/37 Fr) were studied. Log files and cine EPID images were acquired for each fraction. 3D patient dose was reconstructed using log files (Mobius3D) or log files with EPID imaging (PerFRACTION). The treatment planning dose was re-calculated on homogeneous and heterogeneous phantoms, and log files and cine EPID images were acquired...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29472073/positional-uncertainty-of-vaginal-cuff-and-feasibility-of-implementing-portable-bladder-scanner-in-postoperative-cervical-cancer-patients
#17
Hiroyuki Okamoto, Naoya Murakami, C Claudia Carvajal, Yuki Miura, Akihisa Wakita, Satoshi Nakamura, Shie Nishioka, Kotaro Iijima, Koji Inaba, Yoshinori Ito, Tomoyasu Kato, Takafumi Toita, Jun Itami
PURPOSE: To propose a geometrical margin for definition of the vaginal cuff PTV using only CT images of the full bladder (CTfull ) in postoperative cervical cancer patients. METHODS: Twenty-nine operated cervical cancer patients underwent volumetric arc therapy with a bladder filling protocol. This study assessed bladder filling using a portable bladder scanner and cone-beam computed tomography (CBCT) during the entire treatment period. The measured bladder volumes with a BladderScan® were compared with the delineated volume on CBCT...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29472020/sudden-paraplegia-due-to-spontaneous-bleeding-in-a-thoracic-epidural-angiolipoma-and-literature-review
#18
M Lacour, V Gilard, F Marguet, S Curey, A Perez, S Derrey
BACKGROUND: Spinal angiolipomas are rare epidural tumours that are usually revealed by chronic symptoms of medullar irritation. We report a case of acute paraplegia caused by spontaneous bleeding revealing a thoracic angiolipoma. CASE DESCRIPTION: A 17-year-old male patient with no previous medical history was admitted for acute onset of paraplegia with bladder retention and loss of sensation in the lower limbs, preceded by dorsal pain during the three previous days...
February 19, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29471778/evaluation-of-uracil-sodium-ascorbate-and-rosiglitazone-as-promoters-of-urinary-bladder-transitional-cell-carcinomas-in-male-sprague-dawley-rats
#19
Mark Tirmenstein, Evan Janovitz, Thomas Dorr, Yunling Song, Shen-Jue Chen, Karen Granaldi, Kristina D Chadwick, Raja Mangipudy, Michael Graziano, Bassem Attalla, Solomon Haile, Melissa Czajkowski, John R Foster, Ann-Marie Bergholm, Martin Billger, Magnus Söderberg
The purpose of this study was to establish a 2-stage model of urinary bladder carcinogenesis in male Sprague-Dawley rats to identify tumor promoters. In phase 1 of the study, rats ( n = 170) were administered 100 mg/kg of the tumor initiator, N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), twice weekly by oral gavage (po) for a period of 6 weeks. Phase 2 consisted of dividing rats into 4 groups ( n = 40 per group) and administering one of the following for 26 weeks to identify putative tumor promoters: (1) vehicle po, (2) 25 mg/kg/day rosiglitazone po, (3) 5% dietary sodium l-ascorbate, and (4) 3% dietary uracil...
February 2018: Toxicologic Pathology
https://www.readbyqxmd.com/read/29471777/spontaneous-and-drug-induced-arteritis-polyarteritis-in-the-g%C3%A3-ttingen-minipig-review
#20
Zuhal Dincer, Virginie Piccicuto, Ursula Junker Walker, Andreas Mahl, Sean McKeag
Arteritis/polyarteritis occurs spontaneously in many species used in preclinical toxicology studies. In Göttingen minipigs, arteritis/polyarteritis is an occasionally observed background change. In the minipig, this finding differs in frequency and nature from age-related polyarteritis nodosa in rats or monkeys, and Beagle pain syndrome in dogs. In minipigs, it can be present in a single small- or medium-sized artery of an organ or a few organs and is most commonly recorded in the cardiac and extracardiac blood vessels, vagina, oviduct, rectum, epididymis, spinal cord, pancreas, urinary bladder, kidneys, and stomach...
February 2018: Toxicologic Pathology
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