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https://www.readbyqxmd.com/read/28227825/real-time-autonomous-bladder-event-classification-and-closed-loop-control-from-single-channel-pressure-data
#1
Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Steve Majerus, Margot S Damaser, Robert Karam, Steven W Brose, Dennis Bourbeau, Swarup Bhunia
Urinary incontinence, or the loss of bladder control, is a debilitating condition affecting millions worldwide, which significantly reduces quality of life. Neuromodulation of lower urinary tract nerves can be used to treat sensations of urgency in many subjects, including those with Spinal Cord Injury (SCI). Event driven, or conditional stimulation has been investigated as a possible improvement to the state-of-the-art open-loop stimulation systems available today. However, this requires a robust, adaptive, and noise-tolerant method of classifying bladder function from real-time bladder pressure measurements...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227615/smart-monitoring-of-fluid-intake-and-bladder-voiding-using-pressure-sensitive-mats
#2
Madison Cohen-McFarlane, James R Green, Frank Knoefel, Rafik Goubran, Madison Cohen-McFarlane, James R Green, Frank Knoefel, Rafik Goubran, Frank Knoefel, Madison Cohen-McFarlane, Rafik Goubran, James R Green
Pressure sensitive mats have been used in noninvasive smart monitoring for a variety of problems including breathing rate monitoring, sleep monitoring, mobility, and weight. This paper describes a proof of concept application of pressure mats to monitor fluid intake/output (fluid cycle) events during the night. The ability to more accurately track such events has potential implications for monitoring those individuals who have nocturia, a condition where a person wakes at night to urinate. Data were collected from a healthy young female subject instructed to drink as much water as was comfortable (700mL) and lie in a supine position on a mattress located directly on three pressure mats...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227502/posterior-tibial-nerve-stimulation-using-a-wirelessly-powered-system-in-anesthetized-cats
#3
Zainab Moazzam, Austin R Duke, Paul B Yoo, Zainab Moazzam, Austin R Duke, Paul B Yoo, Paul B Yoo, Zainab Moazzam, Austin R Duke
Posterior Tibial Nerve Stimulation (PTNS) is an effective overactive bladder (OAB) therapy where electrical pulses are typically delivered once per week in a 12-week stimulation regime. While the mechanism of action remains unknown, effective long-term delivery of PTNS has recently become a subject of concern. To this end, a multi-contact electrode was surgically placed in the hind limb region of anesthetized cats to (1) investigate the feasibility of using a wirelessly powered system to stimulate PTN afferents and (2) characterize implant-driven effects of stimulation frequency on modulating bladder activity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227419/an-automated-bladder-volume-measurement-algorithm-by-pixel-classification-using-random-forests
#4
Pavan Annangi, Sigmund Frigstad, S B Subin, Anders Torp, Sundararajan Ramasubramaniam, Srinivas Varna, Pavan Annangi, Sigmund Frigstad, S B Subin, Anders Torp, Sundararajan Ramasubramaniam, Srinivas Varna, Sundararajan Ramasubramaniam, Anders Torp, Srinivas Varna, Sb Subin, Pavan Annangi, Sigmund Frigstad
Residual bladder volume measurement is a very important marker for patients with urinary retention problems. To be able to monitor patients with these conditions at the bedside by nurses or in an out patient setting by general physicians, hand held ultrasound devices will be extremely useful. However to increase the usage of these devices by non traditional users, automated tools that can aid them in the scanning and measurement process will be of great help. In our paper, we have developed a robust segmentation algorithm to automatically measure bladder volume by segmenting bladder contours from sagittal and transverse ultrasound views using a combination of machine learning and active contour algorithms...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227181/co-activation-of-saphenous-nerve-fibers-a-potential-therapeutic-mechanism-of-percutaneous-tibial-nerve-stimulation
#5
Christopher W Elder, Paul B Yoo, Christopher W Elder, Paul B Yoo, Paul B Yoo, Christopher W Elder
Percutaneous tibial nerve stimulation (PTNS) is a minimally invasive and effective treatment for overactive bladder (OAB). However, clinical trials show that positive therapeutic outcomes among patients are difficult to predict (failure rate = 35% to 50%). Inconsistencies in the stimulation amplitudes used clinically and those used in preclinical animal studies led us to hypothesize that OAB therapy involves a secondary bladder-inhibitory pathway. In this paper, we implemented and tested a computer model of the human lower leg that investigated the differential activation of the saphenous nerve (SAFN) and tibial nerve (TN) during percutaneous electrical stimulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227180/electrical-stimulation-of-the-saphenous-nerve-in-anesthetized-rats-a-novel-therapeutic-approach-to-treating-overactive-bladder
#6
Zainab Moazzam, Paul B Yoo, Zainab Moazzam, Paul B Yoo, Paul B Yoo, Zainab Moazzam
Posterior Tibial Nerve Stimulation (PTNS) is a minimally invasive yet effective therapy for treating overactive bladder (OAB) symptoms with electrical stimulations applied at 20 Hz coupled with amplitudes approximating the foot-twitch threshold (T). However, pre-clinical studies indicate that PTNS-evoked bladder reflexes require stimulation amplitudes exceeding 2T. The objective of this work was to evaluate the presence of secondary low-threshold sensory pathways in the hind-limb region that can be a potential target of activation during clinical PTNS set-up...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227004/automated-tracking-segmentation-and-trajectory-classification-of-pelvic-organs-on-dynamic-mri
#7
Iman Nekooeimehr, Susana Lai-Yuen, Paul Bao, Alfredo Weitzenfeld, Stuart Hart, Iman Nekooeimehr, Susana Lai-Yuen, Paul Bao, Alfredo Weitzenfeld, Stuart Hart, Paul Bao, Susana Lai-Yuen, Stuart Hart, Alfredo Weitzenfeld, Iman Nekooeimehr
Pelvic organ prolapse is a major health problem in women where pelvic floor organs (bladder, uterus, small bowel, and rectum) fall from their normal position and bulge into the vagina. Dynamic Magnetic Resonance Imaging (DMRI) is presently used to analyze the organs' movements from rest to maximum strain providing complementary support for diagnosis. However, there is currently no automated or quantitative approach to measure the movement of the pelvic organs and their correlation with the severity of prolapse...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226313/risk-of-cancer-in-patients-with-autoimmune-pancreatitis-a-single-center-experience-from-germany
#8
Alexander Schneider, Michael Hirth, Markus Münch, Christel Weiss, J Matthias Löhr, Matthias P Ebert, Roland H Pfützer
BACKGROUND/AIMS: Autoimmune pancreatitis (AIP) has been associated with an increased risk of malignant diseases. We aimed to describe the incidence of malignant diseases in patients with AIP compared to the general population and to characterize the clinical presentation of these patients. METHODS: We retrospectively analyzed data from 28 patients with AIP presenting to the clinic (periods 1998 until 2010, 2012 until September 2015). We retrieved the expected cancer incidence of the general population from the German cancer registry...
February 23, 2017: Digestion
https://www.readbyqxmd.com/read/28225716/divergent-functions-of-the-left-and-right-central-amygdala-in-visceral-nociception
#9
Katelyn E Sadler, Neal A McQuaid, Abigail C Cox, Marissa N Behun, Allison M Trouten, Benedict J Kolber
The left and right central amygdala (CeA) are limbic regions involved in somatic and visceral pain processing. These two nuclei are asymmetrically involved in somatic pain modulation; pain-like responses on both sides of the body are preferentially driven by the right CeA, and in a reciprocal fashion, nociceptive somatic stimuli on both sides of the body predominantly alter molecular and physiological activity in the right CeA. Unknown however, is whether this lateralization also exists in visceral pain processing, and furthermore, what function the left CeA has in modulating nociceptive information...
December 29, 2016: Pain
https://www.readbyqxmd.com/read/28225635/role-of-imaging-in-the-local-staging-of-urothelial-carcinoma-of-the-bladder
#10
Chau Hung Lee, Cher Heng Tan, Silvana de Castro Faria, Vikas Kundra
OBJECTIVE: The purpose of this article is to review imaging modalities used in local staging of bladder urothelial carcinoma. CONCLUSION: Urothelial carcinoma is the most common histologic subtype of bladder cancer, and accurate local staging of this tumor is crucial for management. Traditionally, local staging relied on biopsy. With increasing accuracy of imaging modalities and techniques, imaging also plays an important role in the multidisciplinary care of patients with this disease...
February 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28225151/cytopathologic-differential-diagnosis-of-low-grade-urothelial-carcinoma-and-reactive-urothelial-proliferation-in-bladder-washings-a-logistic-regression-analysis
#11
Ebru Cakir, Ulku Kucuk, Emel Ebru Pala, Ozlem Sezer, Rahmi Gokhan Ekin, Ozgur Cakmak
Conventional cytomorphologic assessment is the first step to establish an accurate diagnosis in urinary cytology. In cytologic preparations, the separation of low-grade urothelial carcinoma (LGUC) from reactive urothelial proliferation (RUP) can be exceedingly difficult. The bladder washing cytologies of 32 LGUC and 29 RUP were reviewed. The cytologic slides were examined for the presence or absence of the 28 cytologic features. The cytologic criteria showing statistical significance in LGUC were increased numbers of monotonous single (non-umbrella) cells, three-dimensional cellular papillary clusters without fibrovascular cores, irregular bordered clusters, atypical single cells, irregular nuclear overlap, cytoplasmic homogeneity, increased N/C ratio, pleomorphism, nuclear border irregularity, nuclear eccentricity, elongated nuclei, and hyperchromasia (p ˂ 0...
February 22, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28224714/urethral-sphincter-injection-of-botulinum-toxin-a-a-review-of-its-application-and-outcomes
#12
REVIEW
Jai Seth, Sophie Rintoul-Hoad, Arun Sahai
The first reported application of Botulinum toxin-A (BTX-A) into the urethral sphincter predates the first documented use in the bladder. The aim of this review is to describe the clinical indications of BTX-A injection into the urethral sphincter and its clinical efficacy. This review of the literature includes the larger more significant published studies that have reported on this use of BTX-A. Case reports and articles not published in English were excluded. There have been many published clinical studies describing the use of BTX-A in the urethral sphincter, four of which are randomized placebo controlled trials...
February 22, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28224172/multi-parametric-mri-findings-of-granulomatous-prostatitis-developing-after-intravesical-bacillus-calmette-gu%C3%A3-rin-therapy
#13
Josh Gottlieb, Robert Princenthal, Martin I Cohen
PURPOSE: To evaluate the multi-parametric MRI (mpMRI) findings in patients with biopsy-proven granulomatous prostatitis and prior Bacillus Calmette-Guérin (BCG) exposure. MATERIALS AND METHODS: MRI was performed in six patients with pathologically proven granulomatous prostatitis and a prior history of bladder cancer treated with intravesical BCG therapy. Multi-parametric prostate MRI images were recorded on a GE 750W or Philips Achieva 3.0 Tesla MRI scanner with high-resolution, small-field-of-view imaging consisting of axial T2, axial T1, coronal T2, sagittal T2, axial multiple b-value diffusion (multiple values up to 1200 or 1400), and dynamic contrast-enhanced 3D axial T1 with fat suppression sequence...
February 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28224113/intensity-modulated-radiation-therapy-with-stereotactic-body-radiation-therapy-boost-for-unfavorable-prostate-cancer-a-report-on-3-year-toxicity
#14
Ima Paydar, Abigail Pepin, Robyn A Cyr, Joseph King, Thomas M Yung, Elizabeth G Bullock, Siyuan Lei, Andrew Satinsky, K William Harter, Simeng Suy, Anatoly Dritschilo, John H Lynch, Thomas P Kole, Sean P Collins
BACKGROUND: Recent data suggest that intensity-modulated radiation therapy (IMRT) plus brachytherapy boost for unfavorable prostate cancer provides improved biochemical relapse-free survival over IMRT alone. Stereotactic body radiation therapy (SBRT) may be a less invasive alternative to brachytherapy boost. Here, we report the 3-year gastrointestinal (GI) and genitourinary (GU) toxicities of IMRT plus SBRT boost. MATERIALS AND METHODS: Between March 2008 and September 2012, patients with prostate cancer were treated with robotic SBRT (19...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28224086/early-robotic-repair-of-vesicouterine-fistula-a-case-report-and-literature-review
#15
Othman J Alamoudi, Mohammed A AlTheneyan, Naif Aldhaam, Maher Moazin
As cesarean sections become a more common mode of delivery, they have become the most likely cause of vesicouterine fistula formation. The associated pathology with repeat cesarean deliveries may make repair of these fistulas difficult. Early robotic-surgery offers a 3-dimensional view of the operative field and allows for intricate movements necessary for complex suturing and dissection. These qualities are advantageous in vesicouterine fistula repair. 42 years old female day 12 post-LSCS in author hospital with history of bladder injury and folly's catheter in place since OR complain of gross hematuria for 8 days...
February 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28223825/usp21-promotes-cell-proliferation-and-metastasis-through-suppressing-ezh2-ubiquitination-in-bladder-carcinoma
#16
Yong Chen, Bo Zhou, Daihui Chen
Bladder cancer (BC) is the second most common malignant tumor of the urinary tract in the world. In this study, we found that ubiquitin-specific protease (USP21) was upregulated in BC and the ectopic expression of USP21 was closely associated with tumor size and metastasis. Moreover, patients with higher levels of USP21 had poorer survival rate. Multiple function analysis such as CCK-8, colony formation, wound healing, and transwell analysis indicated that USP21 regulated cell proliferation and metastasis in bladder carcinoma cell lines...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28223425/role-of-stat3-and-foxo1-in-the-divergent-therapeutic-responses-of-non-metastatic-and-metastatic-bladder-cancer-cells-to-mir-145
#17
Guosong Jiang, Chao Huang, Jingxia Li, Haishan Huang, Honglei Jin, Junlan Zhu, Xue-Ru Wu, Chuanshu Huang
Although miR-145 is the most frequently down-regulated miRNA in bladder cancer (BC), its exact stage-association and downstream effector have not been defined. Here, we found that miR-145 was upregulated in human BC patients with lymph node metastasis and in metastatic T24T cell line. Forced expression of miR-145 promoted anchorage-independent growth of T24T cells accompanied by the down-regulation of forkhead box class O1 (FOXO1). In contrast, in non-metastatic T24 cells, miR-145 overexpression inhibited cell growth with upregulation of FOXO1 and the knockdown of FOXO1 abolished the miR-145-mediated inhibition of cell growth...
February 21, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28222670/microrna-223-3p-inhibits-human-bladder-cancer-cell-migration-and-invasion
#18
Ju Guo, Runfu Cao, Xingwei Yu, Zewen Xiao, Zhiwen Chen
The regulation of initiation and progression during carcinogenesis of bladder carcinoma is not completely elucidated. Dysregulation of microRNAs has been detected to play critical roles in the development of various cancers, including bladder carcinoma, whereas the involvement of miR-223-3p in the tumorigenesis of bladder carcinoma has not been studied. Here, we show that significantly higher levels of nuclear receptor coactivator 1 and significantly lower levels of miR-223-3p were detected in bladder carcinoma tissue, compared to the adjacent non-tumor tissue...
February 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28222669/downregulated-xpa-promotes-carcinogenesis-of-bladder-cancer-via-impairment-of-dna-repair
#19
Yi Zhi, Huixiang Ji, Jinhong Pan, Peng He, Xiaozhou Zhou, Heng Zhang, Zhansong Zhou, Zhiwen Chen
Bladder cancer is the most common malignant tumor of urinary system, largely resulting from failure of repair of DNA damage to the environmental insults. The function of XPA in nucleotide excision repair pathway has been well documented. However, participation of XPA in the repair of DNA double-strand break remains unknown. Here, we reported that bladder cancer expressed low XPA levels compared to adjacent non-tumor bladder tissue, and this phenotype was closely associated with chromosomal aberrations. Moreover, downregulated XPA appeared to increase incidence of chromosome aberration...
February 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28222537/timing-and-kinetics-of-nonmotor-fluctuations-in-advanced-parkinson-s-disease
#20
Christiana Ossig, Daniel Sippel, Mareike Fauser, Florin Gandor, Wolfgang H Jost, Georg Ebersbach, Alexander Storch
BACKGROUND: Nonmotor symptoms (NMS) are known to fluctuate together with motor oscillations in advanced PD, but their timing and kinetics remains enigmatic. OBJECTIVE: To evaluate timing and kinetics of NMS fluctuations. METHODS: Analysis of diary data from 17 fluctuating PD patients. Diaries were completed by rating NMS as absent (defined herein as NMS On state) or present (NMS Off state) and motor function for every hour for 5 consecutive days...
February 8, 2017: Journal of Parkinson's Disease
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