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https://www.readbyqxmd.com/read/28545273/-ileo-vaginal-fistula-caused-by-bladder-cancer-recurrence-after-posterior-colporrhaphy-a-case-report
#1
Y N Wang, F D Wang, L Zhu
No abstract text is available yet for this article.
May 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28545071/characterization-of-the-urinary-microbiome-in-healthy-dogs
#2
Erin N Burton, Leah A Cohn, Carol N Reinero, Hans Rindt, Stephen G Moore, Aaron C Ericsson
The urinary bladder in healthy dogs has dogmatically been considered free of bacteria. This study used culture independent techniques to characterize the healthy canine urinary microbiota. Urine samples collected by antepubic cystocentesis from dogs without urinary infection were used for DNA extraction. Genital tract and rectal samples were collected simultaneously from the same dogs. The V4 hypervariable region of the 16S rRNA bacterial gene was amplified and compared against Greengenes database for OTU assignment and relative abundance for urine, genital, and rectal samples...
2017: PloS One
https://www.readbyqxmd.com/read/28544311/impact-of-body-mass-index-on-robotic-radical-cystectomy-with-intra-corporeal-urinary-diversion
#3
Nariman Ahmadi, Thomas G Clifford, Gus Miranda, Jie Cai, Monish Aron, Mihir M Desai, Inderbir S Gill
OBJECTIVES: To determine the impact of body mass index (BMI) on peri-operative and oncological outcomes following robotic radical cystectomy (RRC) with intra-corporeal urinary diversion (ICUD). SUBJECTS AND METHODS: A total of 216 patients undergoing RRC, extended lymphadenectomy and ICUD (07/2010-12/2015) were categorized into four BMI groups according to the 2004 World Health Organization (WHO) obesity classification: <25 kg/m(2) (normal), 25-29.9 kg/m(2) (pre-obese), 30-34...
May 22, 2017: BJU International
https://www.readbyqxmd.com/read/28544302/predictors-of-delay-to-cystoscopy-and-adequacy-of-investigations-in-patients-with-haematuria
#4
Brian Ngo, Nathan Papa, Marlon Perera, Damien Bolton, Shomik Sengupta
OBJECTIVE: To identify factors that impact on the timeliness and adequacy of haematuria evaluation. PATIENTS AND METHODS: We undertook a retrospective cohort study identifying patients who underwent cystoscopy for investigation of haematuria at our institution between 1 January 2015 and 31 December 2015. Data on patient demographics, smoking status, anticoagulation, type of haematuria and referring clinician were collected. Exclusion criteria included patient age <18 years, known history of bladder/urinary tract/renal cancer, cystoscopy for indications other than haematuria and unknown date of urology consultation...
May 2017: BJU International
https://www.readbyqxmd.com/read/28544301/hospital-volume-and-perioperative-outcomes-for-radical-cystectomy-a-population-study
#5
Cristian Udovicich, Marlon Perera, Molla Huq, Lih-Ming Wong, Daniel Lenaghan
OBJECTIVES: To evaluate the association between hospital volume and perioperative outcomes of radical cystectomy (RC) using state population data for a contemporary Australian cohort. PATIENTS AND METHODS: Patients undergoing RC for urothelial malignancy in the state of Victoria, Australia between July 2003 and June 2014 were identified using the Victorian Admitted Episodes Dataset (VAED). Hospitals were divided into tertiles according to their caseload per year...
May 2017: BJU International
https://www.readbyqxmd.com/read/28544294/factors-affecting-the-timeliness-and-adequacy-of-haematuria-assessment-in-bladder-cancer-a-systematic-review
#6
REVIEW
Brian Ngo, Marlon Perera, Nathan Papa, Damien Bolton, Shomik Sengupta
OBJECTIVES: To review the literature to identify factors affecting haematuria assessment in bladder cancer. METHODS: We performed a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Publications indexed in EMBASE and Medline (PubMed) in March 2016 were searched, using the keywords 'hematuria', 'urinary bladder neoplasm(s)' and 'bladder tumor'. Studies evaluating the timeliness and adequacy of haematuria assessment in the context of bladder cancer were included...
May 2017: BJU International
https://www.readbyqxmd.com/read/28544293/bladder-cancer-time-for-a-higher-profile-in-our-region
#7
EDITORIAL
Nathan Lawrentschuk
No abstract text is available yet for this article.
May 2017: BJU International
https://www.readbyqxmd.com/read/28543959/epidemiology-of-urothelial-carcinoma
#8
REVIEW
Jun Miyazaki, Hiroyuki Nishiyama
The epithelium lining is defined as the mucosal surfaces of the renal collecting tubules, calyces and pelvis, as well as the ureter, bladder and urethra. The term "urothelium" is used to refer to these surfaces. Upper tract urothelial carcinoma is a rare subset of urothelial cancers with a poor prognosis. Urinary bladder cancer is the most common malignancy involving the urinary system. Upper tract urothelial carcinoma is more common in men than in women, with a male-to-female ratio of 2:1. The incidence of urinary bladder cancer is also higher in men...
May 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28542204/similar-regulatory-mechanisms-of-caveolins-and-cavins-by-myocardin-family-coactivators-in-arterial-and-bladder-smooth-muscle
#9
Baoyi Zhu, Catarina Rippe, Tran Thi Hien, Jianwen Zeng, Sebastian Albinsson, Karin G Stenkula, Bengt Uvelius, Karl Swärd
Caveolae are membrane invaginations present at high densities in muscle and fat. Recent work has demonstrated that myocardin family coactivators (MYOCD, MKL1), which are important for contractile differentiation and cell motility, increase caveolin (CAV1, CAV2, CAV3) and cavin (CAVIN1, CAVIN2, CAVIN3) transcription, but several aspects of this control mechanism remain to be investigated. Here, using promoter reporter assays we found that both MKL1/MRTF-A and MKL2/MRTF-B control caveolins and cavins via their proximal promoter sequences...
2017: PloS One
https://www.readbyqxmd.com/read/28542165/subtypes-of-native-american-ancestry-and-leading-causes-of-death-mapuche-ancestry-specific-associations-with-gallbladder-cancer-risk-in-chile
#10
Justo Lorenzo Bermejo, Felix Boekstegers, Rosa González Silos, Katherine Marcelain, Pablo Baez Benavides, Carol Barahona Ponce, Bettina Müller, Catterina Ferreccio, Jill Koshiol, Christine Fischer, Barbara Peil, Janet Sinsheimer, Macarena Fuentes Guajardo, Olga Barajas, Rolando Gonzalez-Jose, Gabriel Bedoya, Maria Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer
Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between the type of Native American ancestry and leading causes of death. After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans and 639,789 deaths, we validate an identified association with gallbladder cancer relying on individual data from 64 gallbladder cancer patients, with and without a family history, and 170 healthy controls...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28541558/drinking-water-contamination-from-perfluoroalkyl-substances-pfas-an-ecological-mortality-study-in-the-veneto-region-italy
#11
Marina Mastrantonio, Edoardo Bai, Raffaella Uccelli, Vincenzo Cordiano, Augusto Screpanti, Paolo Crosignani
: Perfluoroalkyl substances (PFAS), a heterogeneous group of highly stable man-made chemicals, have been widely used since 1960s and can be detected almost ubiquitously in all environmental matrices. In Italy, on January 2014, drinking water contamination in an area of the Veneto Region was detected mainly due to the drain of fluorinated chemicals by a manufacturing company operating since 1964. : The present ecological mortality study was aimed at comparing mortality for some causes of death selected on the basis of previous reported associations, during the period 1980-2013, in municipalities with PFAS contaminated and uncontaminated drinking water on the basis of the levels indicated by the Italian National Health Institute (ISS)...
May 23, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28541036/non-invasive-diagnosis-of-high-grade-urothelial-carcinoma-in-urine-by-raman-spectral-imaging
#12
Hesham K Yosef, Sascha D Krauß, Tatjana Lechtonen, Hendrik Jütte, Andrea Tannapfel, Heiko Udo Käfferlein, Thomas Brüning, Florian Roghmann, Joachim Noldus, Axel Mosig, Samir F El-Mashtoly, Klaus Gerwert
The current gold standard for diagnosis of bladder cancer is cystoscopy, which is an invasive and painful for patients. Therefore, the non-invasive urine cytology is usually used in clinics as an adjunct to cystoscopy. However, it suffers from low sensitivity. Here, a novel non-invasive, label-free approach on urine is presented with high sensitivity. CARS imaging of urine sediments was used in the first step for fast preselection of urothelial cells, where, the high-grade urothelial cancer cells are characterized by a large nucleus to cytoplasm ratio...
May 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28540894/a-randomized-controlled-trial-of-the-effects-of-hydrochlorothiazide-on-overactive-bladder-and-idiopathic-hypercalciuria
#13
Parsa Yousefichaijan, Fatemeh Dorreh, Mohammad Rafiei, Mahdyieh Naziri, Atefeh Azimnejad
Overactive bladder is a stressful condition which affects around 15%-20% of 5- year-old and up to 2% of young adults. One of the most common causes of overactive bladder is hypercalciuria. Our study investigated the effect of hydrochlorothiazide (HCTZ) on overactive bladder and hypercalciuria. This randomized controlled trial was conducted on 88 patients with overactive bladder and idiopathic hypercalciuria. They were randomly divided into the intervention group receiving 1 mg/kg/day of HCTZ for 3 months, and the control group receiving training without any intervention...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28540837/enterovesical-fistula-after-enteric-conversion-of-a-bladder-drained-pancreatic-allograft-a-case-report
#14
Clifford Akateh, Amer Rajab, Mitchell Henry, Ashraf El-Hinnawi
Since the inception of pancreas transplant as a treatment for type 1 diabetes mellitus, there has been considerable debate about the best way to manage exocrine secretions and monitor patients for graft rejection. For patients who undergo bladder exocrine drainage of a pancreatic allograft, a bladder-to-enteric drainage conversion can serve as a rescue procedure in case of anastomotic leaks or other complications. However, this procedure is associated with its own complications, including a rarely described enterovesical fistula...
May 22, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28540814/lyso-thermosensitive-liposomal-doxorubicin-for-treatment-of-bladder-cancer
#15
Andrew S Mikhail, Ayele H Negussie, William F Pritchard, Dieter Haemmerich, David Woods, Ivane Bakhutashvili, Juan Esparza-Trujillo, Sam J Brancato, John Karanian, Piyush K Agarwal, Bradford J Wood
PURPOSE: To evaluate lyso-thermosensitive liposomal doxorubicin (LTLD, ThermoDox(®)) in combination with loco-regional mild hyperthermia (HT) for targeted drug delivery to the bladder wall and potential treatment of bladder cancer. MATERIAL AND METHODS: Porcine in vivo studies were performed with the following groups: (i) intravenous (IV) LTLD with hyperthermia (LTLD + HT); (ii) IV doxorubicin (DOX) with hyperthermia (IV DOX + HT) and (iii) IV LTLD without hyperthermia (LTLD - HT)...
May 10, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540648/impact-of-2015-update-to-the-beers-criteria-on-estimates-of-prevalence-and-costs-associated-with-potentially-inappropriate-use-of-antimuscarinics-for-overactive-bladder
#16
Brandon T Suehs, Cralen Davis, Daniel B Ng, Katherine Gooch
BACKGROUND: Research has demonstrated that the use of potentially inappropriate medication (PIM) is highly prevalent among older individuals and may lead to increased healthcare costs, adverse drug reactions, hospitalizations, and mortality. OBJECTIVES: The purpose of this study was to examine the impact of the 2015 updates to the Beers Criteria on estimates of prevalence and cost associated with potentially inappropriate use of antimuscarinic medications indicated for treatment of overactive bladder (OAB)...
May 24, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28540584/-interstitial-cystitis-diagnosis-and-pharmacological-and-surgical-therapy
#17
A Gonsior, J Neuhaus, L C Horn, T Bschleipfer, J-U Stolzenburg
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic debilitating condition which generally has a severely negative impact on quality of life. An autoimmune genetic predisposition correlates with the theory of pathogenesis. Diagnosis requires history, diaries, physical examination, exclusion of other diseases, cystoscopy with or without hydrodistension and/or bladder biopsy. Novel biological markers are upcoming but not established. Behavioural, pharmacological oral and intravesical, interventional and surgical therapies with a wide range of reported success are available...
May 24, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28540249/liquid-biopsies-for-bladder-cancer
#18
EDITORIAL
Douglas G Ward, Richard T Bryan
The development of accurate urinary biomarkers for the non-invasive detection of urothelial bladder cancer (UBC) could transform patient pathways by reducing reliance on cystoscopy, and the identification of highly prognostic (or even predictive) biomarkers could better guide patient management. A number of approaches are being utilised to address these challenges in both urinary- and plasma-borne tumour DNA (tDNA), so-called "liquid biopsies". Next generation sequencing (NGS) and droplet digital PCR (ddPCR) allow detection of very low levels of such tDNA amongst a large excess of non-tumour DNA, the former permitting large mutation panels to be assessed and the latter potentially identifying ultrarare mutant alleles yet restricted for multiplexing...
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28540231/use-of-botulinum-toxin-for-voiding-dysfunction
#19
REVIEW
David Eldred-Evans, Prokar Dasgupta
The use of botulinum toxin A (BoNT-A) has expanded across a range of lower urinary tract conditions. This review provides an overview of the current indications for BoNT-A in the lower urinary tract and critically evaluates the published evidence within each area. The classic application of BoNT-A has been in the management of refractory neurogenic detrusor overactivity (NDO) and overactive bladder (OAB). There is a large volume of high-quality evidence, including numerous randomized placebo-controlled trials, which demonstrate the efficacy of BoNT-A over a long follow-up period...
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28540206/acute-kidney-injury-from-different-poisonous-substances
#20
Rubina Naqvi
AIM: To report our experience of acute kidney injury (AKI) developed after exposure to poisonous substance. METHODS: Retrospective study where data was collected from case records of patients coming to this institute during January 1990 to May 2016. This institution is a tertiary care center for renal care in the metropolitan city of Karachi, Pakistan. History of ingested substance, symptoms on presentation, basic laboratory tests on arrival, mode of treatment and outcome were recorded from all patients and are presented here...
May 6, 2017: World Journal of Nephrology
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