Raffaella Arfè, Sabrine Bilel, Micaela Tirri, Giorgia Corli, Eva Bergamin, Giovanni Serpelloni, Marta Bassi, Martina Borsari, Federica Boccuto, Tatiana Bernardi, Lorenzo Caruso, Alaaldin M Alkilany, Ousama Rachid, Francesco Botrè, Fabio De-Giorgio, Matteo Marti
Γ-valerolactone (GVL), marketed online as "Tranquilli-G" and "excellent Valium", is used as a legal substitute for γ-hydroxybutyric acid (GHB); however, until now, GVL has only been connected to one Drug-Facilitated Sexual Assault (DFSA) case. Moreover, the pharmaco-toxicological effects of GVL are poorly studied. The aim of this study was to investigate the 1) in vivo effects of gavage administration of GVL (100-3000 mg/kg) on neurological (myoclonia, convulsions), sensorimotor (visual, acoustic, and overall tactile) responses, righting reflex, thermoregulation, motor activity (bar, drag, and accelerod test) and cardiorespiratory changes (heart rate, breath rate, oxygen saturation, and pulse distension) in CD-1 male mice and the 2) in silico ADMET profile of GVL in comparison to GHB and the open active form γ-hydroxyvaleric acid (GHV)...
September 9, 2023: Drug and Alcohol Dependence