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https://www.readbyqxmd.com/read/27900846/plasmablastic-lymphoma-mimicking-carcinomatosis-a-case-report-and-review-of-the-literature
#1
Andrea M Olofson, Eric Y Loo, Paul A Hill, Xiaoying Liu
First identified as a distinct disease entity in HIV-positive patients, plasmablastic lymphoma is a rare aggressive disease which arises predominantly in men and is associated with immunodeficiency of all causes. Although its exact etiology is poorly understood, Epstein-Barr virus infection and MYC gene aberrations have been implicated in its development in both HIV-positive and HIV-negative patients. The disease typically involves extranodal sites with a predilection for the oral cavity but may occur in other locations...
November 30, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27888664/ebv-associated-but-hhv8-unrelated-double-hit-effusion-based-lymphoma
#2
Bo-Jung Chen, David Yen-Ting Chen, Chun-Chi Kuo, Shih-Sung Chuang
Effusion-based lymphoma is a rare and unique type of large B-cell lymphoma presenting in effusion without a mass lesion. It shares many clinicopathological features with primary effusion lymphoma (PEL), but is distinct from PEL by the absence of HHV8 association. Double hit lymphoma (DHL) is an aggressive B-cell lymphoma, defined by concurrent rearrangement of MYC and BCL2 or BCL6. DHL often presents as lymphadenopathy or an extranodal mass, but rarely occurs in effusion. Here we report a 61-year-old male with alcoholic cirrhosis presenting as massive ascites and left pleural effusion...
November 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27886799/igg4-related-disease-advances-in-the-diagnosis-and-treatment
#3
REVIEW
Pilar Brito-Zerón, Xavier Bosch, Manuel Ramos-Casals, John H Stone
IgG4-related disease is a rare immune-mediated systemic disease with the capability of involving essentially any organ. Although the presenting clinical features vary substantially according to the speciality to which patients present first, perhaps the most common clinical presentation is that of single or multiple organ enlargement, arousing suspicion of cancer. The disease is frequently diagnosed unexpectedly in pathological specimens or on imaging studies. The diagnostic approach is complex and includes not only IgG4-related tests (serum levels, circulating plasmablasts, and specific immunohistochemical studies), but also clinical, laboratory, and imaging tests as well as the typical histopathological features (lymphocytic infiltration, storiform fibrosis, eosinophilic infiltration, and obliterative phlebitis)...
April 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27886126/inebilizumab-a-b-cell-depleting-anti-cd19-antibody-for-the-treatment-of-autoimmune-neurological-diseases-insights-from-preclinical-studies
#4
REVIEW
Ding Chen, Sandra Gallagher, Nancy L Monson, Ronald Herbst, Yue Wang
Exaggerated or inappropriate responses by B cells are an important feature in many types of autoimmune neurological diseases. The recent success of B-cell depletion in the treatment of multiple sclerosis (MS) has stimulated the development of novel B-cell-targeting therapies with the potential for improved efficacy. CD19 has emerged as a promising target for the depletion of B cells as well as CD19-positive plasmablasts and plasma cells. Inebilizumab (MEDI-551), an anti-CD19 antibody with enhanced antibody-dependent cell-mediated cytotoxicity against B cells, is currently being evaluated in MS and neuromyelitis optica...
November 24, 2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27867656/erratum-to-cardiac-obstruction-secondary-to-metastatic-invasion-a-rare-complication-of-human-herpes-virus-8-positive-plasmablastic-lymphoma-in-acquired-immunodeficiency-syndrome
#5
(no author information available yet)
[This corrects the article on p. 425 in vol. 4, PMID: 22934146.].
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27824606/omalizumab-reduces-bronchial-mucosal-ige-and-improves-lung-function-in-non-atopic-asthma
#6
Prathap Pillai, Yih-Chih Chan, Shih-Ying Wu, Line Ohm-Laursen, Clare Thomas, Stephen R Durham, Andrew Menzies-Gow, Raj K Rajakulasingam, Sun Ying, Hannah J Gould, Chris J Corrigan
Omalizumab therapy of non-atopic asthmatics reduces bronchial mucosal IgE and inflammation and preserves/improves lung function when disease is destabilised by staged withdrawal of therapy.18 symptomatic, non-atopic asthmatics were randomised (1:1) to receive omalizumab or identical placebo treatment in addition to existing therapy for 20 weeks. Bronchial biopsies were collected before and after 12-14 weeks of treatment, then the patients destabilised by substantial, supervised reduction of their regular therapy...
December 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27812214/ifnar1-signalling-obstructs-icos-mediated-humoral-immunity-during-non-lethal-blood-stage-plasmodium-infection
#7
Ismail Sebina, Kylie R James, Megan S F Soon, Lily G Fogg, Shannon E Best, Fabian de Labastida Rivera, Marcela Montes de Oca, Fiona H Amante, Bryce S Thomas, Lynette Beattie, Fernando Souza-Fonseca-Guimaraes, Mark J Smyth, Paul J Hertzog, Geoffrey R Hill, Andreas Hutloff, Christian R Engwerda, Ashraful Haque
Parasite-specific antibodies protect against blood-stage Plasmodium infection. However, in malaria-endemic regions, it takes many months for naturally-exposed individuals to develop robust humoral immunity. Explanations for this have focused on antigenic variation by Plasmodium, but have considered less whether host production of parasite-specific antibody is sub-optimal. In particular, it is unclear whether host immune factors might limit antibody responses. Here, we explored the effect of Type I Interferon signalling via IFNAR1 on CD4+ T-cell and B-cell responses in two non-lethal murine models of malaria, P...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27801729/richter-syndrome-with-plasmablastic-lymphoma-at-primary-diagnosis-a-case-report-with-a-review-of-the-literature
#8
Andrea Ronchi, Laura Marra, Ferdinando Frigeri, Gerardo Botti, Renato Franco, Annarosaria De Chiara
Richter syndrome (RS) is considered as the rare development of an aggressive lymphoid malignancy in a preexisting small lymphocytic lymphoma/chronic lymphocytic leukemia. The most common aggressive lymphoma developing in this setting is diffuse large B-cell lymphoma, but classical Hodgkin lymphoma and other much rarer entities such as prolymphocytic lymphoma and dendritic cell sarcoma are also described, most frequently in the progression of the disease over time. A clonal relation between the 2 neoplastic proliferations can be frequently found, whereas clonally unrelated cases are commonly considered as independent tumors, probably due to a variable combination of multiple causes, responsible independently for the 2 neoplasms...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27800605/b-cell-activation-with-cd40l-or-cpg-measures-the-function-of-b-cell-subsets-and-identifies-specific-defects-in-immunodeficient-patients
#9
Emiliano Marasco, Chiara Farroni, Simona Cascioli, Valentina Marcellini, Marco Scarsella, Ezio Giorda, Eva Piano Mortari, Lucia Leonardi, Alessia Scarselli, Diletta Valentini, Caterina Cancrini, Marzia Duse, Ola Grimsholm, Rita Carsetti
Around 65% of primary immunodeficiencies are antibody deficiencies. Functional tests are useful tools to study B-cell functions in vitro. However, no accepted guidelines for performing and evaluating functional tests have been issued yet. Here, we report our experience on the study of B-cell functions in infancy and throughout childhood. We show that T-independent stimulation with CpG measures proliferation and differentiation potential of memory B cells. Switched memory B cells respond better than IgM memory B cells...
November 1, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27795651/human-immunodeficiency-virus-associated-plasmablastic-lymphoma-a-case-report
#10
Dinkar Desai, Siddharth Pandit, Shiny Jasphin, Akhil S Shetty
Non-Hodgkin's lymphoma (NHL) is the third common malignant lesion of the oral region. Plasmablastic lymphomas are rare, aggressive neoplasms occurring mostly in human immunodeficiency virus (HIV) infected individual which accounts for approximately 2.6% of all NHL. It usually presents as a diffuse growth and with diffuse pattern of histological presentation. It is very difficult to differentiate this lymphoma from other NHL. Immunohistochemical evaluation of various markers is an important criteria of the diagnostic protocol...
September 2016: Indian Journal of Dentistry
https://www.readbyqxmd.com/read/27794513/long-term-survival-of-primary-intracranial-plasmablastic-lymphoma-case-report-and-review-of-the-literature
#11
Hui Ma, Ming-Hai Wei, Hua-Min Qin, Guan-Yu Wang, Zeng-Chun Hu
BACKGROUND: Primary intracranial plasmablastic lymphoma (PIPBL) is a rare malignant tumor. CASE DESCRIPTION: We present a case of PIPBL in a 32-year-old man who complained of a progressive growing, painful mass on the right parieto-occipital part of head. Computed tomography and magnetic resonance imaging revealed a homogeneously enhanced mass with partial bone destruction. The patient underwent total resection and cranioplasty in one stage. Histopathologic examination showed large tumor cells with immunoblast-like nuclei...
October 26, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27793595/dendritic-cells-regulate-extrafollicular-autoreactive-b-cells-via-t-cells-expressing-fas-and-fas-ligand
#12
Michelle L Ols, Jaime L Cullen, Adriana Turqueti-Neves, Josephine Giles, Mark J Shlomchik
The extrafollicular (EF) plasmablast response to self-antigens that contain Toll-like receptor (TLR) ligands is prominent in murine lupus models and some bacterial infections, but the inhibitors and activators involved have not been fully delineated. Here, we used two conventional dendritic cell (cDC) depletion systems to investigate the role of cDCs on a classical TLR-dependent autoreactive EF response elicited in rheumatoid-factor B cells by DNA-containing immune complexes. Contrary to our hypothesis, cDC depletion amplified rather than dampened the EF response in Fas-intact but not Fas-deficient mice...
November 15, 2016: Immunity
https://www.readbyqxmd.com/read/27793425/impact-of-tofacitinib-treatment-on-human-b-cells-in%C3%A2-vitro-and-in%C3%A2-vivo
#13
Marta Rizzi, Raquel Lorenzetti, Kathleen Fischer, Julian Staniek, Iga Janowska, Arianna Troilo, Valentina Strohmeier, Miriam Erlacher, Mirjam Kunze, Bettina Bannert, Diego Kyburz, Reinhard E Voll, Nils Venhoff, Jens Thiel
B-cells are pivotal to the pathogenesis of rheumatoid arthritis and tofacitinib, a JAK inhibitor, is effective and safe in its treatment. Tofacitinib interferes with signal transduction via cytokine receptors using the common γ-chain. Despite extensive data on T-lymphocytes, the impact of tofacitinib on B-lymphocytes is poorly understood. In this study we assessed the effect of tofacitinib on B-lymphocyte differentiation and function. Tofacitinib treatment strongly impaired in vitro plasmablast development, immunoglobulin secretion and induction of B-cell fate determining transcription factors, Blimp-1, Xbp-1, and IRF-4, in naïve B-cells...
October 26, 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27784538/phenotyping-and-auto-antibody-production-by-liver-infiltrating-b-cells-in-primary-sclerosing-cholangitis-and-primary-biliary-cholangitis
#14
Brian K Chung, Bardia T Guevel, Gary M Reynolds, D B R K Gupta Udatha, Eva Kristine Klemsdal Henriksen, Zania Stamataki, Gideon M Hirschfield, Tom Hemming Karlsen, Evaggelia Liaskou
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are immune-mediated biliary diseases that demonstrate prominent and restricted genetic association with human leukocyte antigen (HLA) alleles. In PBC, anti-mitochondrial antibodies (AMA) are specific and used as diagnostic biomarkers. PSC-relevant auto-antibodies remain controversial despite a distinct HLA association that mirrors archetypical auto-antigen driven disorders. Herein, we compared antibody-secreting B cells (ASCs) in PSC and PBC liver explants to determine if liver-infiltrating ASCs represent an opportune and novel source of disease-relevant auto-antibodies...
October 24, 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27780620/variations-of-b-cell-subpopulations-in-peripheral-blood-of-healthy-mexican-population-according-to-age-relevance-for-diagnosis-of-primary-immunodeficiencies
#15
L Berrón-Ruíz, G López-Herrera, C E Ávalos-Martínez, C Valenzuela-Ponce, E Ramírez-SanJuan, G Santoyo-Sánchez, F Mújica Guzmán, F J Espinosa-Rosales, L Santos-Argumedo
BACKGROUND: Peripheral blood B cells include lymphocytes at various stages of differentiation, each with a specific function in the immune response. All these stages show variations in percentage and absolute number throughout human life. The numbers and proportions of B subpopulation are influenced by factors such as gender, age, ethnicity, and lifestyle. This study establishes reference values according to age of peripheral blood B cell subtypes in healthy Mexican population. METHODS: Peripheral blood from healthy new-borns and adults were analysed for total B cell subpopulations, using surface markers such as CD19, IgM, IgD, CD21, CD24, CD27, and CD38, to identify naïve, memory with and without isotype switch, double-negative, transitional, and plasmablast cells...
October 22, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27778417/pregnancy-alters-the-circulating-b-cell-compartment-in-atopic-asthmatic-women-and-transitional-b-cells-are-positively-associated-with-the-development-of-allergy-manifestations-in-their-progeny
#16
Catarina Martins, Jorge Lima, Glória Nunes, Luís Miguel Borrego
PROBLEM: Maternal atopy is a risk factor for allergy. B cells are poorly studied in reproduction and atopy. We aimed to assess how pregnancy affects B cells in atopic women and whether B cells relate to allergic manifestations in offspring. METHOD OF STUDY: Women with and without atopic asthma, pregnant and non-pregnant were enrolled for the study, and circulating B cells were evaluated by flow cytometry, using CD19, CD27, CD38, IgD, and IgM. RESULTS: Compared to healthy non-pregnant, atopic asthmatic non-pregnant (ANP) women presented increased B cell counts, enlarged memory subsets, less transitional cells, and plasmablasts...
December 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27770825/suppression-of-lupus-nephritis-and-skin-lesions-in-mrl-lpr-mice-by-administration-of-the-topoisomerase-i-inhibitor-irinotecan
#17
Andreas Keil, Sean R Hall, Meike Körner, Martin Herrmann, Ralph A Schmid, Steffen Frese
BACKGROUND: Since the precise mechanism for the pathogenesis of systemic lupus erythematosus (SLE) is unknown, no targeted therapies in addition to immunosuppression are available so far. We recently demonstrated that administration of the topoisomerase I (topo I) inhibitor irinotecan at extremely low concentrations reversed established lupus nephritis in NZB/NZW mice. While profound immunosuppression was absent, we proposed changes in DNA relaxation and anti-double-stranded (ds)DNA antibody binding as the underlying mechanism...
October 22, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27756988/cytology-of-plasma-cell-rich-effusion-in-cases-of-plasma-cell-neoplasm
#18
Debasis Gochhait, Pranab Dey, Neelam Verma
BACKGROUND: Multiple myeloma or plasmacytoma resulting in malignant effusion is rarely described in literature. AIMS: In this paper, we have studied the seven rare cases of plasma cell infiltration in effusion fluid. MATERIALS AND METHODS: We studied six cases of pleural fluid and one case of ascetic fluid. Detailed cytological features, clinical history, bone marrow examinations, serum electrophoresis, and immunofixation data were analyzed...
July 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27750397/array-cgh-predicts-prognosis-in-plasma-cell-post-transplantation-lymphoproliferative-disorders
#19
Clémentine Sarkozy, Sophie Kaltenbach, Pierre Faurie, Danielle Canioni, Françoise Berger, Alexandra Traverse-Glehen, Hervé Ghesquieres, Gilles Salles, Emmanuel Bachy, Marie-Alexandra Alyanakian, Olivier Hermine, Bénédicte Neven, Elizabeth Macintyre, Serge Romana, Thierry Jo Molina, Felipe Suarez, Vahid Asnafi, Julie Bruneau
Plasma-cell post-transplantation lymphoproliferative disorder (PC-PTLD) is a rare monomorphic PTLD entity divided into plasma cell myeloma (PCM) and plasmacytoma-like lesion (PLL) PTLD. To date, there are no exhaustive published cytogenetic data on PC-PTLD. We report array-based comparative genomic hybridization (aCGH) of 10 cases of PCM and PLL-PTLD. Patients had received kidney (n=6), heart (n=2), lung (n=1) or bone marrow (n=1) transplantation. There were six men and median age at time of PTLD was 56.5 years (3-74)...
October 17, 2016: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27746876/post-transplant-lymphoproliferative-disorder-presenting-as-cd20-negative-plasmablastic-lymphoma-in-the-lung
#20
Tasneem Kaleem, Jennifer A Crozier, David M Menke, Taimur Sher
Post-transplant lymphoproliferative disorders (PTLD) are a serious complication of transplantation with a high mortality. Most PTLD present within the first year of transplantation and are associated with Epstein-Barr virus (EBV) infection. Plasmablastic lymphoma (PBL) is a rare but aggressive disease originally described in patients with HIV, presenting most commonly in the jaw and oral mucosa. To our knowledge, this is the first case of PBL presenting as PTLD of the lung in a HIV and EBV negative patient...
September 5, 2016: Rare Tumors
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