keyword
MENU ▼
Read by QxMD icon Read
search

Plasmablast

keyword
https://www.readbyqxmd.com/read/28944344/irf4-couples-anabolic-metabolism-to-th1-cell-fate-determination
#1
Radomir Kratchmarov, Simone A Nish, Wen-Hsuan W Lin, William C Adams, Yen-Hua Chen, Bonnie Yen, Nyanza J Rothman, Ulf Klein, Steven L Reiner
Anabolic metabolism in lymphocytes promotes plasmablast and cytotoxic T cell differentiation at the expense of self-renewal. Heightened expression and function of the transcription factor IFN regulatory factor 4 (IRF4) accompany enhanced anabolic induction and full commitment to functional differentiation in B cells and CD8(+) T cells. In this study, we used a genetic approach to determine whether IRF4 plays an analogous role in Th1 cell induction. Our findings indicate that IRF4 promotes determined Th1 cell differentiation in tandem with anabolic metabolism of CD4(+) T cells...
September 1, 2017: Immunohorizons
https://www.readbyqxmd.com/read/28943879/plasma-cxcl13-but-not-b-cell-frequencies-in-acute-hiv-infection-predicts-emergence-of-cross-neutralizing-antibodies
#2
Jenniffer M Mabuka, Anne-Sophie Dugast, Daniel M Muema, Tarylee Reddy, Yathisha Ramlakhan, Zelda Euler, Nasreen Ismail, Amber Moodley, Krista L Dong, Lynn Morris, Bruce D Walker, Galit Alter, Thumbi Ndung'u
Immunological events in acute HIV-1 infection before peak viremia (hyperacute phase) may contribute to the development of broadly cross-neutralizing antibodies. Here, we used pre-infection and acute-infection peripheral blood mononuclear cells and plasma samples from 22 women, including 10 who initiated antiretroviral treatment in Fiebig stages I-V of acute infection to study B cell subsets and B-cell associated cytokines (BAFF and CXCL13) kinetics for up to ~90 days post detection of plasma viremia. Frequencies of B cell subsets were defined by flow cytometry while plasma cytokine levels were measured by ELISA...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28930701/leukocyte-telomere-length-t-cell-composition-and-dna-methylation-age
#3
Brian H Chen, Cara L Carty, Masayuki Kimura, Jeremy D Kark, Wei Chen, Shengxu Li, Tao Zhang, Charles Kooperberg, Daniel Levy, Themistocles Assimes, Devin Absher, Steve Horvath, Alexander P Reiner, Abraham Aviv
Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with chronological age. One measure of DNA methylation age─ the extrinsic epigenetic age acceleration (EEAA)─ is highly predictive of all-cause mortality. We examined the relation between LTL and EEAA. LTL was measured by Southern blots and leukocyte DNA methylation was determined using Illumina Infinium HumanMethylation450 BeadChip in participants in the Women's Health Initiative (WHI; n=804), the Framingham Heart Study (FHS; n=909) and the Bogalusa Heart study (BHS; n=826)...
September 20, 2017: Aging
https://www.readbyqxmd.com/read/28929004/intraocular-plasmablastic-lymphoma-in-a-hiv-patient
#4
Carolline Fontes Alves Mariano, Glauce Lunardelli Trevisan, Antonio Augusto Velasco E Cruz, Fernando Chahud
Plasmablastic lymphoma (PBL) is a rare B-cell lymphoma occurring mainly in HIV patients. The tumor frequently involves extranodal sites such as the oral cavity, nasal cavity, gastrointestinal tract, skin, and lungs. The neoplastic cells are characterized by a plasmablastic appearance and typical immunophenotype that indicates plasma cell differentiation. Herein, we report a case of intraocular involvement by plasmablastic lymphoma in a HIV patient with a long history of cytomegalovirus retinitis and loss of vision...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28916317/presence-of-human-herpesvirus-8-hhv-8-dna-sequences-in-patients-with-lymphoproliferative-diseases-and-chronic-blood-disorders
#5
Hossein Keyvani, Mohammad Hadi Karbalaie Niya, Maryam Esghaei, Farah Bokharaei-Salim, Seyed Hamid Reza Monavari
OBJECTIVE: Human herpesvirus 8 (HHV-8) is the causative agent of Kaposi's sarcoma (KS), but it has also been associated with different hematologic malignancies, including plasmablastic lymphoma, Multicentric Castleman's disease (MCD), primary effusion lymphoma (PEL) and various atypical lymphoproliferative disorders. Patients with underlying lymphoproliferative diseases and chronic blood disorders who become infected with this virus are at risk for human malignancies. This small study reported the frequency of human herpesvirus 8 in 81 Iranian patients with lymphoproliferative disorders for estimation of possible factors affecting malignancy...
September 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28913874/an-algorithmic-approach-to-diagnose-haematolymphoid-neoplasms-in-effusion-by-combining-morphology-immunohistochemistry-and-molecular-cytogenetics
#6
L Chen, J S Zhang, D G Liu, D Cui, Z L Meng
OBJECTIVE: There are limited studies of cytology diagnosis of haematopoietic and lymphoid tumours in serosal effusion except for occasional case reports. We would like to demonstrate an algorithmic approach for accurate diagnosis, especially in patients without previous history. METHODS: We reviewed 36 cases of lymphoma diagnosed in serosal effusion following an algorithmic approach. Suspected tumour cells were classified into small, intermediate and large sizes and two characteristic forms of plasmacytoid and Reed Sternberg-like on smears (step 1), followed by utilising panels of immunohistochemical markers and Epstein-Barr encoding region in situ hybridisation on cell blocks (step 2)...
September 15, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28905187/altered-b-cell-homeostasis-in-patients-with-major-depressive-disorder-and-normalization-of-cd5-surface-expression-on-regulatory-b-cells-in-treatment-responders
#7
Diana Ahmetspahic, Kathrin Schwarte, Oliver Ambrée, Christian Bürger, Vladislava Falcone, Katharina Seiler, Mehrdad Rahbar Kooybaran, Laura Grosse, Fernand Roos, Julia Scheffer, Silke Jörgens, Katja Koelkebeck, Udo Dannlowski, Volker Arolt, Stefanie Scheu, Judith Alferink
Pro-inflammatory activity and cell-mediated immune responses have been widely observed in patients with major depressive disorder (MDD). Besides their well-known function as antibody-producers, B cells play a key role in inflammatory responses by secreting pro- and anti-inflammatory factors. However, homeostasis of specific B cell subsets has not been comprehensively investigated in MDD. In this study, we characterized circulating B cells of distinct developmental steps including transitional, naïve-mature, antigen-experienced switched, and non-switched memory cells, plasmablasts and regulatory B cells by multi-parameter flow cytometry...
September 13, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28894451/inflammatory-conditions-dictate-the-effect-of-mesenchymal-stem-or-stromal-cells-on-b-cell-function
#8
Franka Luk, Laura Carreras-Planella, Sander S Korevaar, Samantha F H de Witte, Francesc E Borràs, Michiel G H Betjes, Carla C Baan, Martin J Hoogduijn, Marcella Franquesa
The immunomodulatory capacity of mesenchymal stem or stromal cells (MSC) makes them a promising tool for treatment of immune disease and organ transplantation. The effects of MSC on B cells are characterized by an abrogation of plasmablast formation and induction of regulatory B cells (Bregs). It is, however, unknown how MSC interact with B cells under inflammatory conditions. In this study, adipose tissue-derived MSC were pretreated with 50 ng/ml IFN-γ for 96 h (MSC-IFN-γ) to simulate inflammatory conditions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28893942/kaposi-sarcoma-herpesvirus-pathogenesis
#9
REVIEW
Giuseppe Mariggiò, Sandra Koch, Thomas F Schulz
Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a phylogenetically old human virus that co-evolved with human populations, but is now only common (seroprevalence greater than 10%) in sub-Saharan Africa, around the Mediterranean Sea, parts of South America and in a few ethnic communities. KSHV causes three human malignancies, Kaposi sarcoma, primary effusion lymphoma, and many cases of the plasmablastic form of multicentric Castleman's disease (MCD) as well as occasional cases of plasmablastic lymphoma arising from MCD; it has also been linked to rare cases of bone marrow failure and hepatitis...
October 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28878909/a-rare-case-of-epstein-barr-virus-related-plasmacytoma-involving-maxillary-sinus-mucosa
#10
Julie D Gibbs, Marino E Leon, Kenia Liu, Johnny Nguyen, Ling Zhang
Extramedullary plasmacytomas, Epstein-Bar virus (EBV) associated, are rarely encountered and usually have a fairly good clinical outcome. EBV+ plasmacytoma may cause a diagnostic dilemma as it phenotypically resembles an aggressive plasmablastic lymphoma (PBL). Herein, we report a unique case with maxillary EBV+ plasmacytoma from a 76-year-old immunocompetent individual.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28878127/autoantibody-producing-plasmablasts-after-b-cell-depletion-identified-in-muscle-specific-kinase-myasthenia-gravis
#11
Panos Stathopoulos, Aditya Kumar, Richard J Nowak, Kevin C O'Connor
Myasthenia gravis (MG) is a B cell-mediated autoimmune disorder of neuromuscular transmission. Pathogenic autoantibodies to muscle-specific tyrosine kinase (MuSK) can be found in patients with MG who do not have detectable antibodies to the acetylcholine receptor (AChR). MuSK MG includes immunological and clinical features that are generally distinct from AChR MG, particularly regarding responsiveness to therapy. B cell depletion has been shown to affect a decline in serum autoantibodies and to induce sustained clinical improvement in the majority of MuSK MG patients...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28878078/potent-plasmablast-derived-antibodies-elicited-by-the-nih-dengue-vaccine
#12
Diogo M Magnani, Cassia G T Silveira, Michael J Ricciardi, Lucas Gonzalez-Nieto, Núria Pedreño-Lopez, Varian K Bailey, Martin J Gutman, Helen S Maxwell, Aline Domingues, Priscilla R Costa, Lilian Ferrari, Raphaella Goulart, Mauricio A Martins, José M Martinez-Navio, Sebastian P Fuchs, Jorge Kalil, Maria do Carmo Timenetsky, Jens Wrammert, Stephen S Whitehead, Dennis R Burton, Ronald C Desrosiers, Esper G Kallas, David I Waktins
Exposure to dengue virus (DENV) is thought to elicit lifelong immunity, mediated by DENV-neutralizing antibodies (nAbs). However, Abs generated by primary infections confer serotype-specific protection, and immunity against other serotypes only develops after subsequent infections. Accordingly, the induction of these nAb responses acquired after serial DENV infections has been a long sought-after goal for vaccination. Nonetheless, it is still unclear if tetravalent vaccines can elicit or recall nAbs. Here, we have characterized the responses from a volunteer who had been previously exposed to DENV and was immunized with the live attenuated tetravalent vaccine Butantan-DV, developed by the NIH and Butantan...
September 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28870527/identification-and-phenotyping-of-circulating-autoreactive-proteinase-3-specific-b-cells-in-patients-with-pr3-anca-associated-vasculitis-and-healthy-controls
#13
Divi Cornec, Alvise Berti, Amber Hummel, Tobias Peikert, Jacques-Olivier Pers, Ulrich Specks
OBJECTIVES: To develop a method to detect and phenotype circulating proteinase 3 (PR3)-specific B-cells in patients with PR3-ANCA associated vasculitis (AAV). METHODS: Recombinant human PR3 (rPR3) was tagged with FITC or biotin, and its binding characteristics were studied by flow cytometry using three hybridoma cell lines secreting antibodies (Ab) against human PR3, mouse PR3 (no cross-reactivity with human PR3), and human neutrophil elastase. We measured the proportion of PR3-specific B-cells and studied their surface phenotype in patients with PR3-AAV and healthy controls (HC)...
September 1, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28863153/triple-dmard-treatment-in-early-rheumatoid-arthritis-modulates-synovial-t-cell-activation-and-plasmablast-plasma-cell-differentiation-pathways
#14
Alice M Walsh, Mihir D Wechalekar, Yanxia Guo, Xuefeng Yin, Helen Weedon, Susanna M Proudman, Malcolm D Smith, Sunil Nagpal
OBJECTIVES: This study sought to investigate the genome-wide transcriptional effects of a combination of disease modifying anti-rheumatic drugs (tDMARD; methotrexate, sulfasalazine and hydroxychloroquine) in synovial tissues obtained from early rheumatoid arthritis (RA) patients. While combination DMARD strategies have been investigated for clinical efficacy, very little data exists on the potential molecular mechanism of action. We hypothesized that tDMARD would impact multiple biological pathways, but the specific pathways were unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28860565/interleukin-6-dependent-growth-in-a-newly-established-plasmablastic-lymphoma-cell-line-and-its-therapeutic-targets
#15
Sohtaro Mine, Tsunekazu Hishima, Akihiko Suganuma, Hitomi Fukumoto, Yuko Sato, Michiyo Kataoka, Tsuyoshi Sekizuka, Makoto Kuroda, Tadaki Suzuki, Hideki Hasegawa, Masashi Fukayama, Harutaka Katano
Plasmablastic lymphoma (PBL) is a rare, highly aggressive subtype of non-Hodgkin lymphoma with plasma-cell differentiation occurring typically in immune-suppressed patients such as those with AIDS. This study reports the establishment and characterization of a new cell line, PBL-1, derived from a patient with AIDS-associated PBL. Morphological assessment of PBL-1 indicated plasma-cell differentiation with a CD20(-) CD38(+) CD138(+) immunophenotype and IgH/c-myc translocation. The cell line harbours Epstein-Barr virus, but a 52...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28857172/interleukin-36-receptor-mediates-the-crosstalk-between-plasma-cells-and-synovial-fibroblasts
#16
Verena Schmitt, Madelaine Hahn, Verena Kästele, Olga Wagner, Maximilian Wiendl, Anja Derer, Adriano Taddeo, Stefanie Hahne, Andreas Radbruch, Hans-Martin Jäck, Wolfgang Schuh, Dirk Mielenz, Steffen Gay, Georg Schett, Axel J Hueber, Silke Frey
The IL-1 family member IL-36α has proinflammatory and pathogenic properties in psoriasis. IL-36α binds to the IL-36 receptor leading to nuclear factor kappa B/mitogen activated protein kinase mediated cytokine release. The IL-36R antagonist prevents recruitment of IL-1 receptor accessory protein and therefore IL-36-dependent cell activation. In inflamed human tissue, we previously could show that resident B cells and plasma cells (PC) express IL-36α. Further, fibroblast-like synoviocytes (FLS) produced proinflammatory cytokines upon IL-36α-stimulation...
August 31, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28834574/baff-and-baff-receptors-fakes-and-facts
#17
Gianfranco Ferraccioli, Elisa Gremese
The analysis of BAFF receptors before and after B cell depletion therapy (BCDT) might offer a clue to understand whether some B cell subsets, may represent useful biomarkers of biological and clinical response. Among the BAFF receptors, the AA have shown in a cohort of rheumatoid arthritis (RA) patients, by FACS analysis of the MFI (median fluorescence intensity) that TACI, and BCMA, do not change whereas BR3, the most important, appears to be decreased either before as well as after BCDT, in all B cells subsets but not in Plasmablasts, the subset more important and depleted by BCDT ...
August 23, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28829194/cd19-lo-cd27-hi-plasmablasts-suppress-harmful-th17-inflammation-through-interleukin-10-pathway-in-colorectal-cancer
#18
Hui Mao, Fei Pan, Zhiyong Wu, Zhikuan Wang, Yanhua Zhou, Pengfei Zhang, Miaomiao Gou, Guanghai Dai
The enrichment of CD20(+) and CD138(+) immune cells were previously associated with improved survival in colorectal cancer (CRC). We previously discovered that the resected tumors in CRC patients were highly enriched with interleukin (IL)-10-producing CD19(lo)CD27(hi) plasmablasts with potential suppressor functions. It is still unknown what roles the CD19(lo)CD27(hi) plasmablasts play in CRC patients. In this study, we first demonstrated that B cells from peripheral blood mononuclear cells (PBMCs) could be stimulated to resemble tumor-infiltrating plasmablasts using a coculture containing Caco-2 and heat-killed bacteria...
August 22, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28825948/11c-methionine-avid-plasmablastic-lymphoma
#19
Salvatore Annunziata, Annarosa Cuccaro, Carmelo Caldarella, Lucia Leccisotti, Stefan Hohaus
A 73-year-old woman had a diagnosis of a plasmablastic lymphoma by the excision of the right parotid gland. Two years after the diagnosis, the patient underwent a whole-body C-methionine PET/CT in order to evaluate the amino acid avidity of a scalp metastasis and for plasmablastic lymphoma restaging. C-methionine uptake was detected in the scalp, in several bone sites, and in the cricoid cartilage. Plasmablastic lymphoma is a subtype of B-cell lymphoma with an aggressive behavior and a poor prognosis. C-methionine appears to be a promising tracer for paraprotein-producing neoplasms...
August 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28821561/zika-virus-activates-de-novo-and-cross-reactive-memory-b-cell-responses-in-dengue-experienced-donors
#20
Thomas F Rogers, Eileen C Goodwin, Bryan Briney, Devin Sok, Nathan Beutler, Alexander Strubel, Rebecca Nedellec, Khoa Le, Michael E Brown, Dennis R Burton, Laura M Walker
Zika virus (ZIKV) shares a high degree of homology with dengue virus (DENV), suggesting that preexisting immunity to DENV could affect immune responses to ZIKV. We have tracked the evolution of ZIKV-induced B cell responses in three DENV-experienced donors. The acute antibody (plasmablast) responses were characterized by relatively high somatic hypermutation and a bias toward DENV binding and neutralization, implying the early activation of DENV clones. A DENV-naïve donor in contrast showed a classical primary plasmablast response...
August 18, 2017: Science Immunology
keyword
keyword
28842
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"