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Fertility preservation

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https://www.readbyqxmd.com/read/29159821/the-d0-14-d-ratio-a-new-paleodemographic-index-and-equation-for-estimating-total-fertility-rates
#1
Clare McFadden, Marc F Oxenham
OBJECTIVES: The objectives of this study were to develop a new subadult-adult ratio for application to sites with good infant representation and to produce an equation to estimate the total fertility rate for a population based on the age-at-death ratio. A new approach is required as current methods exclude the 0-4 years age category due to presumed underenumeration of infants. While this is true for some skeletal samples, others experience good infant representation. MATERIALS AND METHODS: Using age-at-death data and total fertility rates for 52 countries from the United Nations database for the year 1960, we examined the correlation between three age-at-death ratios and the fertility rate...
November 21, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29159540/is-fertility-preservation-safe-for-adult-non-metastatic-gynecologic-rhabdomyosarcoma-patients-systematic-review-and-pooled-survival-analysis-of-137-patients
#2
REVIEW
Maha At Elsebaie, Zeinab Elsayed
PURPOSE: Recently, conservative approaches such as wide local excisions and neoadjuvant chemotherapy are being considered to select young adult females with gynecologic RMS who have strong desire to preserve fertility. This analysis aims to identify prognosticators affecting survival outcomes and defining potential candidacy for fertility-preservation. Another focus is to explore the role of chemotherapy in reducing the need for aggressive surgery and the role of radiotherapy in decreasing rates of local failure...
November 20, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29157035/a-new-approach-to-fertility-preserving-surgery-in-patients-with-placenta-accretaplacenta-accreta
#3
Sergey Barinov, Yuliya Tirskaya, Irina Medyannikova, Irina Shamina, Inna Shavkun
BACKGROUND: The aim of this study was to evaluate the efficacy of a novel combined surgical approach utilising: (1) two autonomous balloon Zhukovsky catheters (vaginal and uterine), (2) bilateral ligation of the descending uterine artery branches, (3) external supraplacental pleated sutures, and (4) either excision of a small area of placenta accreta or full metroplasty, for the management of uterine bleeding associated with placenta accreta of various severity. MATERIALS AND METHODS: The study included medical records of 92 pregnant women with placenta accreta undergoing caesarean section...
November 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29155965/is-frozen-embryo-transfer-better-for-mothers-and-babies-can-cumulative-meta-analysis-provide-a-definitive-answer
#4
Abha Maheshwari, Shilpi Pandey, Edwin Amalraj Raja, Ashalatha Shetty, Mark Hamilton, Siladitya Bhattacharya
BACKGROUND: Initial observational studies and a systematic review published 5 years ago have suggested that obstetric and perinatal outcomes are better in offspring conceived following frozen rather than fresh embryo transfers, with reduced risks of preterm birth, small for gestational age, low birth weight and pre-eclampsia. More recent primary studies are beginning to challenge some of these findings. We therefore conducted an updated systematic review and cumulative meta-analysis to examine if these results have remained consistent over time...
November 13, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29155509/current-strategies-and-future-perspectives-in-fertility-preservation-for-cancer-patients
#5
Romeo Micu, Bogdan Petrut, Cristina Zlatescu-Marton, Alexandra Traila, Radu Harsa, Patriciu Achimas-Cadariu
Nowadays, cancer is being detected at younger ages. Health care providers should consider cancer patients' desire towards fertility preservation before the initiation of possibly sterilizing treatments. The aim of the current review was to register the current state of fertility preservation procedures available for male and female cancer patients.
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29153762/basic-and-clinical-approaches-for-fertility-preservation-and-restoration-in-cancer-patients
#6
REVIEW
Jose V Medrano, María Del Mar Andrés, Sofía García, Sonia Herraiz, Teresa Vilanova-Pérez, Ellen Goossens, Antonio Pellicer
As gonadotoxic adverse effects of antineoplastic treatments can result in infertility, gamete cryopreservation is routinely offered to patients as the strategy to preserve their fertility. However, there are many cases where gold standards cannot be applied, as is the case for prepubertal cancer patients and others unable to produce gametes or their precursors at the moment of diagnosis. With an increasing number of cancer survivors in our society, strategies using either cryopreserved gonadal tissue or stem cells have been developed to allow cancer survivors to achieve fatherhood, and recent advances in the field have increased public interest...
November 15, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29153060/using-pyruvate-kinase-as-a-predictor-for-patient-with-endometrial-cancer-having-complex-hyperplasia-with-atypia-to-prevent-hysterectomy-and-preserve-fertility-retrospective-immunohistochemical-study
#7
Susan Hosseini Nasab, Neda Jooya, Aryan Esmaeili, Neda Zarrin Khameh, Concepcion Diaz-Arrastia, Mazdak Momeni
OBJECTIVES: To explore whether the metabolic switches proceed or succeed the histological changes in precancerous lesions. To validate pyruvate kinase isoform 1 (PKM1) and pyruvate kinase isoform 2 (PKM2) as a histological biomarker to predict the progression of endometrial hyperplasia into invasive cancer status. METHODS: The records of 56 patients with a primary diagnosis of complex hyperplasia with atypia after endometrial biopsy were selected and analyzed retrospectively...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29150522/addressing-decisional-conflict-about-fertility-preservation-helping-young-female-cancer-survivors-family-planning-decisions
#8
Madleina Müller, Corinne Urech, Jacky Boivin, Verena Ehrbar, Rebecca Moffat, Rosanna Zanetti Daellenbach, Christoph Rochlitz, Sibil Tschudin
BACKGROUND: Health professionals are challenged by a growing number of young long-term cancer survivors with their specific needs with regard to family planning. This study aimed at assessing decisional conflict (DC) in young female cancer patients regarding fertility preservation, identifying demographic, fertility and fertility preservation related factors, which may affect DC, and assessing the helpfulness of various decision-supports. METHODS: A retrospective, cross-sectional, web-based survey via an online questionnaire available in three languages with specific items concerning cancer, fertility, fertility preservation and the validated Decisional Conflict Scale targeted at current or former female cancer patients aged 18-45 years, with cancer types or treatment potentially affecting reproductive function...
November 17, 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/29149096/-fertility-preservation-in-the-oncology-patient
#9
REVIEW
Anibal Scarella Chamy, César Díaz-García, Sonia Herraiz, Jhenifer Kliemchen Rodrigues
In recent years, medical advances have substantially improved survival of cancer patients, generating growing concern about the quality of life of the survivors. Increased attention has been paid to reproductive problems after oncological treatments. International guidelines on fertility preservation in cancer patients require that healthcare teams discuss, as early as possible, the impact of cancer treatments on fertility and encourage access to fertility preservation techniques. The development of these techniques in women is a recent effort and many patients and health care providers are not familiar with their rapid expansion...
November 16, 2017: Medwave
https://www.readbyqxmd.com/read/29146391/small-diameter-hysteroscopic-metroplasty-for-a-septate-uterus-after-open-assisted-laparoscopic-radical-trachelectomy
#10
Akimasa Takahashi, Hiroyuki Kanao, Nobuhiro Takeshima
STUDY OBJECTIVE: To describe a two-step fertility preservation technique for early-stage cervical cancer of a patient with a complete septate uterus. DESIGN: A step-by-step demonstration and explanation of the technique in a surgical video (Canadian Task Force Classification III). SETTING: Center for cancer, a tertiary referral center. The patient provided informed consent to use images and videos of the procedure. Institutional Review Board approval was not required for this kind of procedure...
November 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29145928/note-of-clarification-potential-risks-to-offspring-of-intrauterine-exposure-to-maternal-age-related-obstetric-complications
#11
Juan J Tarín, Miguel A García-Pérez, Antonio Cano
Several hypotheses have been proposed to explain the negative effects of delayed motherhood on an offspring's morbidity later in life. However, these hypotheses are not supported by clinical and epidemiological evidence. Because advanced maternal age is associated with increased risk of obstetric complications, the aim of the present study was to ascertain whether the negative effects on offspring of intrauterine exposure to maternal age-related obstetric complications may explain the reported negative effects of delayed motherhood on offspring...
August 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29132275/evidence-of-biased-advertising-in-the-case-of-social-egg-freezing
#12
Christopher Barbey
Oocyte cryopreservation, or 'egg freezing,' is the practice of preserving unfertilised oocytes for later fertilisation. This practice allows women to extend their reproductive years. In 2014, Facebook and Apple announced that they would subsidise their female employees' elective - or 'social' - use of egg freezing so that these women can more easily reconcile the demands of career and family life. This announcement engendered controversy and moral debate. Given that social egg freezing (SEF) is becoming more popular, ethical and empirical analyses are warranted...
November 2017: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
https://www.readbyqxmd.com/read/29129415/-ivf-and-endometriosis-oocyte-donation-and-fertility-preservation
#13
Emmanuelle Mathieu d'Argent, Jean-Marie Antoine
Endometriosis is a common condition, causing pain and infertility. In infertile woman with superficial peritoneal endometriosis and patent tubes, laparoscopy is recommended, followed by ovarian stimulation alone or in combination with intrauterine inseminations. In case of ovarian or deep endometriosis, the indications of surgery and assisted reproductive technologies remain to be defined precisely. In vitro fertilization is generally proposed after the failure of up to three inseminations, directly for ovarian or deep endometriosis, or in case of an associated factor of infertility, mainly male...
November 9, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29128697/comparison-of-pregnancy-outcomes-using-either-an-ovsynch-or-a-cosynch-protocol-for-the-first-timed-ai-with-liquid-or-frozen-semen-in-lactating-dairy-cows
#14
S Borchardt, L Schüller, L Wolf, C Wesenauer, W Heuwieser
The objective of this study was to evaluate fertility to the first timed AI (TAI) using either liquid semen or frozen semen after an Ovsynch or a Cosynch protocol in lactating dairy cows. The hypothesis was that there is an increase in fertility to the first TAI when cows are inseminated with liquid semen compared to that when frozen semen is used in a Cosynch protocol. Lactating dairy cows (n = 1724; 540 primiparous, 1184 multiparous) from 9 commercial dairy farms were enrolled on a weekly basis to facilitate first timed AI...
November 9, 2017: Theriogenology
https://www.readbyqxmd.com/read/29126204/proteomic-analysis-of-germinal-vesicles-in-the-domestic-cat-model-reveals-candidate-nuclear-proteins-involved-in-oocyte-competence-acquisition
#15
P-C Lee, D E Wildt, P Comizzoli
STUDY QUESTION: Do nuclear proteins in the germinal vesicle (GV) contribute to oocyte competence acquisition during folliculogenesis? SUMMARY ANSWER: Proteomic analysis of GVs identified candidate proteins for oocyte competence acquisition, including a key RNA processing protein - heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1). WHAT IS KNOWN ALREADY: The domestic cat GV, which is physiologically similar to the human GV, gains the intrinsic ability to resume meiosis and support early embryo development during the pre-antral-to-antral follicle transition...
November 8, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29126179/dimethyl-sulfoxide-and-quercetin-prolong-the-survival-motility-and-fertility-of-cold-stored-mouse-sperm-for-10-days
#16
Hidetaka Yoshimoto, Toru Takeo, Naomi Nakagata
Technology for preserving sperm is useful for disseminating valuable male genetic traits. Cold storage is suitable for easily transporting sperm as an alternative to the shipment of live animals. However, there is a technical limitation in that the fertility of cold-stored sperm declines within 3 days. To overcome this problem, we examined the protective effects of quercetin and dimethyl sulfoxide (DMSO). DMSO and quercetin maintained the fertility and motility of cold-stored sperm for 10 days. In addition, quercetin attenuated the reduction of mitochondrial membrane potential of cold-stored sperm during sperm preincubation, allowing the induction of capacitation, and it localized to the midpiece of sperm...
November 8, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29125369/pregnancy-and-live-birth-after-successful-cancer-treatment-in-young-women-the-need-to-improve-fertility-preservation-and-advice-for-female-cancer-patients
#17
Richard A Anderson, W Hamish B Wallace
No abstract text is available yet for this article.
November 10, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29124460/medical-egg-freezing-the-importance-of-a-patient-centered-approach-to-fertility-preservation
#18
Marcia C Inhorn, Daphna Birenbaum-Carmeli, Lynn M Westphal, Joseph Doyle, Norbert Gleicher, Dror Meirow, Hila Raanani, Martha Dirnfeld, Pasquale Patrizio
PURPOSE: This binational qualitative study of medical egg freezing (MEF) examined women's motivations and experiences, including their perceived needs for patient-centered care in the midst of fertility- and life-threatening diagnoses. METHODS: Forty-five women who had undertaken MEF were interviewed in the USA (33 women) and in Israel (12 women) between June 2014 and August 2016. Interviews lasted approximately 1 h and were conducted by two senior medical anthropologists, one in each country...
November 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29123075/evaluation-of-the-awareness-of-attitude-to-and-knowledge-about-fertility-preservation-in-cancer-patients-among-clinical-practitioners-in-hong-kong
#19
J Pw Chung, T Th Lao, T C Li
INTRODUCTION: Individuals can be exposed to gonadotoxic agents in the course of treatment for cancers and other medical conditions. Fertility preservation refers to strategies that aim to preserve fertility by protecting it against the damage inflicted by gonadotoxic treatment. Many young patients are prescribed gonadotoxic treatment without prior counselling. This study aimed to study the awareness of, attitude to, and knowledge about fertility preservation among clinicians in Hong Kong...
November 10, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29121511/medical-egg-freezing-and-cancer-patients-hopes-fertility-preservation-at-the-intersection-of-life-and-death
#20
Marcia C Inhorn, Daphna Birenbaum-Carmeli, Pasquale Patrizio
Egg freezing (i.e., oocyte cryopreservation) is a new reproductive technology that allows women's eggs to be frozen and stored for future use. Over the past five years, so-called "medical egg freezing" (MEF) has begun to play a major role as a form of fertility preservation for young women with cancer and other fertility-threatening medical conditions. Indeed, women who are candidates for MEF are often facing the "double jeopardy" of fertility loss and potential death. In this article, we examine the experiences of the first generation of women to use MEF in the United States and Israel, two countries where experimental use of MEF began early, and where MEF is now offered clinically in many in vitro fertilization (IVF) clinics...
October 31, 2017: Social Science & Medicine
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