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Fertility preservation

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https://www.readbyqxmd.com/read/28221816/priorities-in-fertility-decisions-for-reproductive-aged-cancer-patients-fertility-attitudes-and-cancer-treatment-study
#1
Dina M Flink, Laxmi A Kondapalli, Yvonne Kellar-Guenther
PURPOSE: The Fertility Attitudes and Cancer Treatment Study (FACTS) aims at better understanding the reasons and priorities of young adult cancer patients making decisions for fertility preservation (FP). Identifying the factors that center around a patient's fertility decisions will support the development of educational tools for providers and improve clinical care to meet patients' reproductive needs. METHODS: An exploratory qualitative study was conducted of 27 newly diagnosed male and female cancer patients who had presented for an oncofertility consultation...
February 21, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28219466/factors-of-importance-when-selecting-sows-as-embryo-donors
#2
A Nohalez, C A Martinez, J Reixach, M Diaz, J Vila, I Colina, I Parrilla, J L Vazquez, J Roca, M A Gil, H Rodriguez-Martinez, E A Martinez, C Cuello
The improvement in porcine embryo preservation and non-surgical embryo transfer (ET) procedures achieved in recent years represents essential progress for the practical use of ET in the pig industry. This study aimed to evaluate the effects of parity, weaning-to-estrus interval (WEI) and season on reproductive and embryonic parameters at day 6 after insemination of donor sows superovulated after weaning. The selection of donor sows was based on their reproductive history, body condition and parity. The effects of parity at weaning (2 to 3, 4 to 5 or 6 to 7 litters), season (fall, winter and spring), and WEI (estrus within 3 to 4 days), and their interactions on the number of corpus luteum, cysts in sows with cysts, number and quality of viable and transferable embryos, embryo developmental stage and recovery and fertilization rates were evaluated using linear mixed effects models...
February 21, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28217671/in-vitro-fertilization-outcome-in-women-with-diminished-ovarian-reserve
#3
Bo Hyon Yun, Gieun Kim, Seon Hee Park, Eun Bee Noe, Seok Kyo Seo, SiHyun Cho, Young Sik Choi, Byung Seok Lee
OBJECTIVE: This study aimed to identify factors that affect in vitro fertilization (IVF) outcomes in women with diminished ovarian reserve (DOR). METHODS: We reviewed 99 IVF cycles in 52 women with DOR between September 2010 and January 2015. DOR was defined as serum anti-Müllerian hormone level of <1.1 ng/dL or serum follicle-stimulating hormone level of ≥20 mIU/mL. Total 96 cycles in 50 patients were evaluated after excluding fertility preservation cases...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28216917/uterine-conserving-surgery-in-a-case-of-cervicovaginal-agenesis-with-unicornuate-uterus
#4
Vineet Mishra, Suwa Ram Saini, Sakshi Nanda, Sumesh Choudhary, Priyankur Roy, Tanvir Singh
The presence of cervicovaginal agenesis with unicornuate uterus is a very rare mullerian anomaly. Its true incidence is still unknown. The presence of functioning unicornuate uterus poses a great challenge for a gynecologist because a successful repair could restore normal menses and may preserve a patient's fertility. Hence, we report a case of 16-year-old unmarried female who presented with chief complaints of primary amenorrhea with cyclical lower abdominal pain. On clinical and radiological evaluation, she was diagnosed with complete cervicovaginal agenesis with right unicornuate uterus (hematometra and hematosalpinx)...
October 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28214435/evaluation-of-fertility-after-operative-hysteroscopy-to-remove-retained-products-of-conception
#5
Louise Sonnier, Antoine Torre, Pauline Broux, Arnaud Fauconnier, Cyrille Huchon
: Evaluation of fertility after operative hysteroscopy to remove retained products of conception. OBJECTIVE: To study fertility after operative hysteroscopy for the management of prolonged trophoblastic retention, and the complications of this procedure. STUDY DESIGN: Retrospective cohort in a university hospital. RESULTS: 115 patients underwent operative hysteroscopy for the treatment of prolonged post-partum and post-abortum retention between January 2008 and December 2011...
February 6, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28211534/in-vitro-differentiation-of-fertile-sperm-from-cryopreserved-spermatogonia-of-the-endangered-endemic-cyprinid-honmoroko-gnathopogon-caerulescens
#6
Shogo Higaki, Manami Shimada, Kazuaki Kawamoto, Takaaki Todo, Toshihiro Kawasaki, Ikuo Tooyama, Yasuhiro Fujioka, Noriyoshi Sakai, Tatsuyuki Takada
Many endemic fish species are threatened with extinction. Conservation strategies and the restoration of endemic fish after extinction must therefore be investigated. Although sperm cryopreservation is indispensable for the conservation of endangered fishes, the limited number of mature fish and limited availability (volume and period) of sperm from small endemic fish hinders the optimization and practical use of this material. In this report, we demonstrate the in vitro differentiation of fertile sperm from cryopreserved spermatogonia of juveniles of the endangered small cyprinid honmoroko (Gnathopogon caerulescens), which is endemic to Lake Biwa in Japan...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28207285/improvements-in-clinical-trials-information-will-improve-the-reproductive-health-and-fertility-of-cancer-patients
#7
Angela Dauti, Brigitte Gerstl, Serena Chong, Orin Chisholm, Antoinette Anazodo
There are a number of barriers that result in cancer patients not being referred for oncofertility care, which include knowledge about reproductive risks of antineoplastic agents. Without this information, clinicians do not always make recommendations for oncofertility care. The objective of this study was to describe the level of reproductive information and recommendations that clinicians have available in clinical trial protocols regarding oncofertility management and follow-up, and the information that patients may receive in clinical trials patient information sheets or consent forms...
February 16, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28197717/operative-techniques-and-complications-of-extraction-and-transplantation-of-ovarian-tissue-the-erlangen-experience
#8
Matthia W Beckmann, Ralf Dittrich, Laura Lotz, Patricia G Oppelt, Sebastian Findeklee, Thomas Hildebrandt, Katharina Heusinger, Susanne Cupisti, Andreas Müller
PURPOSE: Extracting ovarian tissue before oncologic therapy and transplanting it afterwards are increasingly being used to preserve fertility in women. This study describes standardized and safe operative procedures, with few complications, and reports the resulting ovarian function and pregnancy rates. METHODS: The standardized operative techniques for removing and transplanting ovarian tissue used at the Erlangen center are: for tissue removal, one-third to half of the tissue from one ovary is excised with scissors, without tissue coagulation; for subsequent transplantation, pieces of ovarian tissue are placed in a retroperitoneal pocket without closure of the pocket...
February 15, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28188938/multipotent-stem-cell-and-current-application
#9
Aligholi Sobhani, Neda Khanlarkhani, Maryam Baazm, Farzaneh Mohammadzadeh, Atefeh Najafi, Shayesteh Mehdinejadiani, Fereydoon Sargolzaei Aval
Stem cells are self-renewing and undifferentiated cell types that can be differentiate into functional cells. Stem cells can be classified into two main types based on their source of origin: Embryonic and Adult stem cells. Stem cells also classified based on the range of differentiation potentials into Totipotent, Pluripotent, Multipotent, and Unipotent. Multipotent stem cells have the ability to differentiate into all cell types within one particular lineage. There are plentiful advantages and usages for multipotent stem cells...
January 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28187094/extraperitoneal-radical-trachelectomy-with-pelvic-lymphadenectomy-a-novel-fertility-preserving-option-for-early-stage-cervical-cancer-patients
#10
Seiji Mabuchi, Tadashi Kimura
OBJECTIVE: Radical trachelectomy combined with pelvic lymphadenectomy has been used to treat early stage cervical cancer patients who wish to preserve their fertility. Although vaginal, abdominal, laparoscopic, and robotic approaches have been used during this procedure, all of these approaches cause peritoneal damage, which could result in periadnexal adhesion. The aim of the present study was to introduce and discuss a novel fertility-preserving option, extraperitoneal radical trachelectomy with pelvic lymphadenectomy...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28186840/fertility-preservation-care-for-children-and-adolescents-with-cancer-an-inquiry-to-quantify-professionals-barriers
#11
Nikoletta Panagiotopoulou, Frederik W van Delft, Juliet P Hale, Jane A Stewart
PURPOSE: There is a growing interest in fertility preservation as emerging research is highlighting the prevalence of infertility among young cancer survivors and its negative impact on quality of life. Previous qualitative research has identified barriers of fertility preservation care among professionals. The aim of this study was to assess the prevalence of these barriers among pediatric and adolescent oncology healthcare professionals and evaluate factors that influence them. METHODS: Based on previously identified barriers and experts' input, a questionnaire was developed and sent to 88 professionals drawn from the multidisciplinary pediatric and adolescent oncology team of a large Principal Treatment Centre...
February 10, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28186611/-ethical-issues-of-oocyte-donation
#12
Yanjin Liu, Libai Cai
The birth and development of oocyte donation technology have brought hope for women with poor ovarian reserve and repeated failure for in vitro fertilization, as well as for those with chromosomal abnormalities, premature ovarian failure, or at perimenopausal or menopausal stages. It has not only preserved their reproductive right, but also stabilized their families and increased social harmony. However, this technology does not only involve infertile couples themselves, but also social and ethical issues concerning their families and the society...
February 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28185173/ovarian-function-suppression-in-premenopausal-women-with-early-stage-breast-cancer
#13
REVIEW
Matteo Lambertini, Lucia Del Mastro, Giulia Viglietti, Noam F Pondé, Cinzia Solinas, Evandro de Azambuja
Breast cancers arising in young women are biologically more aggressive, and most of these patients are candidates to receive aggressive treatments that include the use of chemotherapy. As most of these tumors express the hormone receptors (i.e., luminal disease), these patients are also candidates to adjuvant endocrine therapy. Chemotherapy-induced amenorrhea showed to be prognostic in young patients with luminal breast cancer. However, the role of ovarian function suppression (OFS) in addition to standard adjuvant treatments has been largely debated over the past years...
January 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28181670/risk-of-persistent-or-recurrent-neoplasia-in-conservatively-treated-women-with-cervical-adenocarcinoma-in-situ-with-negative-histological-margins
#14
Aime Munro, Jim Codde, Katrina Spilsbury, Colin J R Stewart, Nerida Steel, Yee Leung, Jason Tan, Stuart G Salfinger, Ganendra R Mohan, James B Semmens, Paul A Cohen
INTRODUCTION: Conservative treatments including cold knife cone biopsy (CKC) or loop electrosurgical excision procedure (LEEP) are fertility-preserving alternatives to hysterectomy. The risks of persistent cervical neoplasia in women with negative surgical margins following conservative treatment of adenocarcinoma-in-situ (AIS) are uncertain. This study aims to investigate the risk of persistent or recurrent cervical neoplasia (AIS, adenocarcinoma and/or high-grade cervical squamous intraepithelial neoplasia (CIN)) and compliance with follow-up recommendations in conservatively treated women with AIS and negative histopathological margins...
February 9, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28174376/-practice-of-fertility-preservation-for-cancer-patients-in-the-aya-generation
#15
Yodo Sugishita, Nao Suzuki
The adolescent and young adult(AYA)generation is defined as population aged 15 through 39years and is widely used by many organizations and associations. Female fertility preservation consists of oocyte freezing, embryo freezing, ovarian tissue freezing and transplantation, and ovarian protection by the GnRH agonist in anticancer agents. In particular, owing to the characteristics of fertility preservation for cancer patients in the AYA generation, a longer frozen storage period is possible. Special consideration for the devised and informed consent protocol for adolescent patients and psychological support are needed when patients gets older...
January 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28174013/update-on-fertility-restoration-from-prepubertal-spermatogonial-stem-cells-how-far-are-we-from-clinical-practice
#16
Maria Grazia Giudice, Francesca de Michele, Jonathan Poels, Maxime Vermeulen, Christine Wyns
Fertility preservation in prepubertal boys facing gonadotoxic treatment is still at the experimental stage. Nevertheless cryopreservation of immature testicular tissue (ITT) obtained by small testicular biopsy is being increasingly proposed in reproductive care clinics for this purpose. Different approaches to in vivo or in vitro mature spermatogonial stem cells (SSCs) contained in ITT have been studied: autografting of testicular tissue pieces, transplantation of one's own purified germ cell suspensions, and in vitro maturation (IVM) for subsequent use of sperm for intra cytoplasmic sperm injection (ICSI)...
February 2, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28170079/fertility-preservation-and-survival-among-young-women-with-early-ovarian-cancer-living-in-us-counties-with-gynecologic-oncologist-services
#17
R Tyler Hillman, Cheryl C Saenz, Michael T McHale, Steven C Plaxe
OBJECTIVE: To examine the association between living in a county with gynecologic oncologist provision, the performance of fertility sparing surgery, and survival among young women with early epithelial ovarian cancer. METHODS: The present retrospective cohort study was based on the SEER 18 dataset of the US National Cancer Institute. Women younger than 45 years with early stage epithelial ovarian cancer diagnosed between 2000 and 2012 were included. Logistic regression and Cox proportional hazards methods were used to analyze all-cause survival...
February 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28166301/stimulus-triggered-enhancement-of-chilling-tolerance-in-zebrafish-embryos
#18
Bernadett Faragó, Tímea Kollár, Katalin Szabó, Csilla Budai, Eszter Losonczi, Gergely Bernáth, Zsolt Csenki-Bakos, Béla Urbányi, Csaba Pribenszky, Ákos Horváth, Judit Cserepes
BACKGROUND: Cryopreservation of zebrafish embryos is still an unsolved problem despite market demand and massive efforts to preserve genetic variation among numerous existing lines. Chilled storage of embryos might be a step towards developing successful cryopreservation, but no methods to date have worked. METHODS: In the present study, we applied a novel strategy to improve the chilling tolerance of zebrafish embryos by introducing a preconditioning hydrostatic pressure treatment to the embryos...
2017: PloS One
https://www.readbyqxmd.com/read/28161526/low-fertility-preservation-utilization-among-transgender-youth
#19
Leena Nahata, Amy C Tishelman, Nicole M Caltabellotta, Gwendolyn P Quinn
PURPOSE: Research demonstrates a negative psychosocial impact of infertility among otherwise healthy adults, and distress among adolescents facing the prospect of future infertility due to various medical conditions and treatments that impair reproductive health. Guidelines state that providers should counsel transgender youth about potential infertility and fertility preservation (FP) options prior to initiation of hormone therapy. The purpose of this study was to examine the rates of fertility counseling and utilization of FP among a cohort of adolescents with gender dysphoria seen at a large gender clinic...
February 1, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28155019/the-positive-effect-of-a-dedicated-adolescent-and-young-adult-fertility-program-on-the-rates-of-documentation-of-therapy-associated-infertility-risk-and-fertility-preservation-options
#20
Jeremy Lewin, Justin Ming Zheng Ma, Laura Mitchell, Seline Tam, Natasha Puri, Derek Stephens, Amirrtha Srikanthan, Philippe Bedard, Albiruni Razak, Michael Crump, David Warr, Meredith Giuliani, Abha Gupta
PURPOSE: Minimal data exist regarding documentation of therapy-associated infertility risk (IR) and fertility preservation (FP) options during the initial oncology consultation prior to systemic therapy. This study investigated factors affecting IR/FP documentation and assessed the effect of implementation of an Adolescent and Young Adult (AYA) program on documentation rates. METHODS: A retrospective review of charts of patients receiving gonadotoxic therapy was undertaken for documentation of IR/FP pre- and post-implementation of an AYA program...
February 2, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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