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https://www.readbyqxmd.com/read/29346171/a-common-procedure-with-an-uncommon-pathology-triamcinolone-acetonide-eyelid-injection
#1
Natalie Wolkow, Frederick A Jakobiec, Mark P Hatton
Local corticosteroid injections are frequently employed by ophthalmologists to treat a variety of ocular, periocular, and orbital inflammatory conditions. Triamcinolone acetonide is a slowly dissolving crystalline corticosteroid that is often used for this purpose because of its prolonged anti-inflammatory effect. On occasion, previously injected corticosteroid material persists in tissues longer than anticipated, creating nodules that may masquerade as other disease conditions, or appearing incidentally in excised lesions on histopathologic examination...
January 17, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29346051/diagnosis-treatment-and-outcome-of-and-risk-factors-for-ophthalmic-disease-in-leopard-geckos-eublepharis-macularius-at-a-veterinary-teaching-hospital-52-cases-1985-2013
#2
K Tomo Wiggans, David Sanchez-Migallon Guzman, Christopher M Reilly, Claire Vergneau-Grosset, Philip H Kass, Steven R Hollingsworth
OBJECTIVE To describe diagnosis, treatment, and outcome of and risk factors for ophthalmic disease in leopard geckos (Eublepharis macularius) evaluated at a veterinary teaching hospital. DESIGN Retrospective case series. ANIMALS 112 of 144 (78%) leopard geckos that were evaluated at a veterinary teaching hospital in January 1985 through October 2013 and for which sufficient medical record information was available. PROCEDURES Information from medical records was used to identify leopard geckos with ophthalmic disease, characterize cases, and determine risk factors for the presence of ophthalmic disease...
February 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29345957/besifloxacin-a-critical-review-of-its-characteristics-properties-and-analytical-methods
#3
Eliane Gandolpho Tótoli, Hérida Regina Nunes Salgado
Bacterial conjunctivitis has high impact on the health of the population, since it represents more than a third of ocular pathologies reported by health services worldwide. There is a high incidence of bacterial resistance to the antimicrobials most commonly used for the treatment of conjunctivitis. In this context, besifloxacin stands out, since it is a fluoroquinolone developed exclusively for topical ophthalmic use, presenting a low risk of developing resistance due to its reduced systemic exposure. Bausch & Lomb markets it as ophthalmic suspension, under the trade name Besivance™...
January 18, 2018: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/29344492/bilateral-hypopyon-uveitis-in-chronic-myeloid-leukemia
#4
Mudit Tyagi, Vishal Govindhari, Rajeev R Pappuru, Vikas Ambiya
Background: A leukemic hypopyon is considered an early sign of central nervous system involvement or systemic relapse. A differential diagnosis of masquerade syndromes should be considered in cases of hypopyon uveitis that are atypical or unresponsive to treatment. We report a case of a 45-year-old man who presented with bilateral hypopyon uveitis and was subsequently diagnosed as having chronic myeloid leukemia. Method: Retrospective case review. Results: A 45-year-old diabetic male presented with diminished vision in both eyes for 10 days...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344491/hemophagocytic-lymphohistiocytosis-in-adults-with-intraocular-involvement-clinicopathologic-features-of-3-cases
#5
M Adelita Vizcaino, Charles G Eberhart, Fausto J Rodriguez
Background/Aims: Hemophagocytic lymphohistiocytosis (HLH) is an infrequent inflammatory multisystemic syndrome. Only rare cases with ophthalmic involvement describing their pathologic features have been previously reported. Methods: We report 3 cases of adult-onset HLH with bilateral ocular involvement and describe their clinicopathologic features. Results: Three adult males - 2 with a history of viral infection - developed persistent fever, fatigue, bone marrow abnormalities, and irreversible multiorgan failure...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344477/is-there-an-increased-prevalence-of-asteroid-hyalosis-in-eyes-with-uveal-melanoma-a-histopathologic-study
#6
EDITORIAL
Christopher K H Burris, Amir A Azari, Mozhgan R Kanavi, Richard R Dubielzig, Vivian Lee, Justin L Gottlieb, Heather D Potter, Kyungmann Kim, Meisha L Raven, Maria E Rodriguez, Devasis N Reddy, Daniel M Albert
During the planning meeting for the Collaborative Ocular Melanoma Study (COMS) prior to the start of patient recruitment in 1986, there was an interest expressed in determining whether a relationship existed between the presence of uveal melanoma (UM) and asteroid hyalosis (AH). To answer this question, the ophthalmic examination form (unlike the pathology form for enucleated eyes) for each COMS patient asked whether AH was present or not. Though an increased prevalence was not found, this result was never published...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344060/neuro-ophthalmic-presentation-of-neuro-sweet-disease
#7
Padmaja Sudhakar, Stuart Tobin, William O Connor, Sachin Kedar
Acute febrile neutrophilic dermatosis (Sweet syndrome) is a systemic inflammatory condition usually associated with autoimmune or neoplastic processes and characterised by inflammatory dermatologic lesions such as erythematous plaques and papules associated with fever and leukocytosis. Neurological and ophthalmological involvement is rare. The authors describe an unusual case of Sweet syndrome associated with microscopic polyangiitis presenting with papilloedema, anterior uveitis, and skin rash. Years later, he developed acute posterior multifocal placoid pigment epitheliopathy...
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344059/retinitis-pigmentosa-sine-pigmento-mimicking-a-chiasm-disease
#8
Francesco Pellegrini, Giovanni Prosdocimo, Francesco Romano, Emanuela Interlandi
A 75-year-old woman presented to her ophthalmologist complaining of visual loss for several years. The ophthalmic examination was remarkable for a bitemporal visual field defect. Magnetic resonance imaging (MRI) scan of the brain was normal without evidence of chiasm compression. Neuro-ophthalmic examination was consistent with a retinal rather than a chiasmal disease. Retinal multimodal imaging helped in the correct diagnosis of retinitis pigmentosa, later confirmed by genetic testing.
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29343840/vision-status-in-older-adults-the-brazilian-amazon-region-eye-survey
#9
Solange R Salomão, Adriana Berezovsky, João M Furtado, Arthur G Fernandes, Sergio Muñoz, Nívea N Cavascan, Marcela C Cypel, Cristina C Cunha, Galton C Vasconcelos, Márcia R K H Mitsuhiro, Paula Y Sacai, Mauro Campos, Paulo H A Morales, Marcos J Cohen, Jacob M Cohen, Sung E S Watanabe, Rubens Belfort
Older adults living in remote areas with limited access to health services are at higher risk to develop visual impairment and blindness. We conducted a population-based survey to determine the vision status in subjects 45 years of age and older from urban and rural areas of Parintins city, Brazilian Amazon Region. Participants underwent ophthalmic examination, including uncorrected (UCVA), presenting (PVA) and best-corrected visual acuity (BCVA). Vision status was described as lines of visual acuity (VA) impairment and lines of VA improvement from UCVA to BCVA and from PVA to BCVA in the better-seeing eye...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343147/estimation-of-intra-arterial-chemotherapy-distribution-to-the-retina-in-pediatric-retinoblastoma-patients-using-quantitative-digital-subtraction-angiography
#10
Sravani Kondapavulur, Daniel L Cooke, Andrew Kao, Matthew R Amans, Matthew Alexander, Robert Darflinger, Christopher F Dowd, Randall T Higashida, Bertil Damato, Van V Halbach, Katherine K Matthay, Steven W Hetts
Background and purpose The purpose of this article is to estimate the distribution of superselective intra-arterial chemotherapy (IAC) delivery to ocular target tissue using quantitative digital subtraction angiography (qDSA). Materials and methods From March 2010 to January 2016, 50 ophthalmic artery contrast DSAs obtained immediately prior to IAC infusions in 22 patients were analyzed. This study was conducted under a retrospective review IRB (no. 10-01862). Parametric color-coded DSAs (iFlow, Siemens Medical) were post-processed (MATLAB, The Mathworks Inc...
January 1, 2018: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29342879/ophthalmic-drug-delivery-systems-for-antibiotherapy-a-review
#11
REVIEW
Marion Dubald, Sandrine Bourgeois, Véronique Andrieu, Hatem Fessi
The last fifty years, ophthalmic drug delivery research has made much progress, challenging scientists about the advantages and limitations of this drug delivery approach. Topical eye drops are the most commonly used formulation in ocular drug delivery. Despite the good tolerance for patients, this topical administration is only focus on the anterior ocular diseases and had a high precorneal loss of drugs due to the tears production and ocular barriers. Antibiotics are popularly used in solution or in ointment for the ophthalmic route...
January 13, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29342435/the-2016-american-academy-of-ophthalmology-iris%C3%A2-registry-intelligent-research-in-sight-database-characteristics-and-methods
#12
Michael F Chiang, Alfred Sommer, William L Rich, Flora Lum, David W Parke
PURPOSE: To describe the characteristics of the patient population included in the 2016 IRIS® Registry (Intelligent Research in Sight) database for analytic aims. DESIGN: Description of a clinical data registry. PARTICIPANTS: The 2016 IRIS Registry database consists of 17 363 018 unique patients from 7200 United States-based ophthalmologists in the United States. METHODS: Electronic health record (EHR) data were extracted from the participating practices and placed into a clinical database...
January 13, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29342029/association-of-involutional-lower-eyelid-entropion-with-reduced-upper-eyelid-position-relative-to-the-corneal-light-reflex-quantification-of-facial-asymmetry
#13
Paul O Phelps, Edward J Wladis, Dale R Meyer
PURPOSE: To investigate the association between upper eyelid position relative to the corneal light reflex (MRD1) and to delineate an association between eyelid height and involutional lower eyelid entropion. METHODS: Retrospective study of patients presenting for entropion repair to an academic ophthalmic plastic surgery service. A total of 111 patients were included in the study; 95 had unilateral involutional lower eyelid entropion, and 16 had bilateral lower eyelid entropion...
January 16, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29342028/lymphedema-distichiasis-syndrome-in-a-male-patient-followed-for-16-years
#14
Ana Beatriz D Grisolia, Christine C Nelson
Distichiasis is a challenging condition that may require multiple surgical interventions. Besides ophthalmologic concerns in children, distichiasis may be part of the lymphedema-distichiasis syndrome, which presents with lymphedema of variable time of onset. Other significant systemic disorders such as coarctation of the aorta and varicose veins have been reported in association with this syndrome and must be reviewed for proper patient care. The authors report the case of a 22-year-old male patient who had been treated for distichiasis and followed for 16 years...
January 16, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29341996/retinal-arterio-arterial-collaterals-in-susac-syndrome
#15
Robert A Egan, Guy Jirawuthiworavong, Norah S Lincoff, John J Chen, Courtney E Francis, Jacqueline A Leavitt
BACKGROUND: The ophthalmic findings of Susac syndrome (SS) consist of visual field defects related to branch retinal artery occlusion (BRAO), and fluorescein angiography (FA) reveals a unique staining pattern. To date, retinal arterial collateral development has been described only in a single patient. Given that the immunopathological process in SS induces retinal ischemia, it is conceivable that abnormal blood vessel development may occur in affected individuals. METHODS: This is a retrospective observational study...
January 16, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29341922/sustained-release-timolol-maleate-loaded-ocusert-based-on-biopolymer-composite
#16
Revathy V Nair, Shefrin S, Akhil Suresh, Anoop K R, Sreeja C Nair
In the present investigation, the effect of timolol maleate loaded ocuserts was studied as an alternative for conventional anti-glaucoma formulation. Ocuserts were prepared using natural polymer sodium alginate and ethyl cellulose. Physico-chemical properties along with drug entrapment efficiency (94-98%), content uniformity (93.1% ± 0.264-98.00% ± 0.321), in vitro drug release (83.42% ± 0.35 at end of 12 hours), ex vivo permeation all showed satisfactory results, which was found to follow zero order kinetics...
January 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29341918/asymmetric-flow-field-flow-fractionation-for-the-characterization-of-globule-size-distribution-in-complex-formulations-a-cyclosporine-ophthalmic-emulsion-case
#17
Haiou Qu, Jiang Wang, Yong Wu, Jiwen Zheng, Yellela S R Krishnaiah, Mohammad Absar, Stephanie Choi, Muhammad Ashraf, Celia N Cruz, Xiaoming Xu
Commonly used characterization techniques such as cryogenic-transmission electron microscopy (cryo-TEM) and batch-mode dynamic light scattering (DLS) are either time consuming or unable to offer high resolution to discern the poly-dispersity of complex drug products like cyclosporine ophthalmic emulsions. Here, a size-based separation and characterization method for globule size distribution using an asymmetric flow field flow fractionation (AF4) is reported for comparative assessment of cyclosporine ophthalmic emulsion drug products (model formulation) with a wide size span and poly-dispersity...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29339644/changes-in-central-macular-thickness-and-retinal-nerve-fiber-layer-thickness-in-eyes-with-vogt-koyanagi-harada-disease-a-2-year-follow-up-study
#18
Yong-Seop Han, Kyung-Sup Shin, Woo-Hyuk Lee, Jung-Yeul Kim
PURPOSE: To investigate the central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness in eyes with Vogt-Koyanagi-Harada (VKH) disease associated with optic disc swelling and serous retinal detachment through a 24-month follow-up period. METHODS: We prospectively investigated 28 eyes of 14 treatment-naïve patients with acute VKH disease associated with optic disc swelling and serous retinal detachment and 30 eyes of 15 normal individuals to compare changes in the CMT and average RNFL thickness...
January 16, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29339249/semifluorinated-alkane-based-systems-for-enhanced-corneal-penetration-of-poorly-soluble-drugs
#19
Priyanka Agarwal, Dieter Scherer, Bernhard Günther, Ilva D Rupenthal
Semifluorinated alkanes (SFAs) are amphiphilic liquids that can dissolve hydrophobic drugs to form clear solutions. This study evaluated the potential of two SFAs to act as vehicle for topical ocular drug delivery. After confirming ocular safety, an ex vivo corneal penetration model was developed to determine drug distribution and corneal bioavailability. Hydrophobic dye distribution in the different corneal layers was visualised under a confocal microscope. Corneal bioavailability of cyclosporine A (CsA) dissolved in perfluorobutylpentane (F4H5) or perfluorohexyloctane (F6H8) was compared to commercially available CsA ophthalmic emulsions, Restasis® and Ikervis®...
January 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29338772/incidence-risk-factors-and-impact-of-protocolised-care-on-exposure-keratopathy-in-critically-ill-adults-a-two-phase-prospective-cohort-study
#20
Obaid Kousha, Zubaid Kousha, Jonathan Paddle
BACKGROUND: Exposure keratopathy (EK) has a high incidence in critically ill patients. We aimed to determine the rate of EK in patients admitted to our intensive care unit (ICU), identify risk factors for developing EK and ascertain the effectiveness of a protocol to prevent EK. METHODS: We undertook a two-phase prospective cohort single-centre study in a general adult ICU. The first phase of the study was observational. In the second phase of the study an eye care protocol was introduced...
January 16, 2018: Critical Care: the Official Journal of the Critical Care Forum
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