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https://www.readbyqxmd.com/read/27911373/the-mouse-isolated-perfused-kidney-technique
#1
Jan Czogalla, Frank Schweda, Johannes Loffing
The mouse isolated perfused kidney (MIPK) is a technique for keeping a mouse kidney under ex vivo conditions perfused and functional for 1 hr. This is a prerequisite for studying the physiology of the isolated organ and for many innovative applications that may be possible in the future, including perfusion decellularization for kidney bioengineering or the administration of anti-rejection or genome-editing drugs in high doses to prime the kidney for transplantation. During the time of the perfusion, the kidney can be manipulated, renal function can be assessed, and various pharmaceuticals administered...
November 17, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27911101/in-vivo-and-ex-vivo-evaluation-of-inflammation-and-apoptosis-induced-after-smile-procedures-for-different-refractive-error-range
#2
Leonardo Mastropasqua, Roberta Calienno, Claudia Curcio, Rodolfo Mastropasqua, Mario Nubile, Niccolò Salgari, Manuela Lanzini
PURPOSE: To detect corneal inflammation and apoptosis induced after small incision lenticule extraction (SMILE) at different refractive corrections for moderate to high values of myopia. METHODS: Fifty patients (50 eyes) suffering from medium to high myopia (spherical equivalent refraction from -3.75 to -10.00 diopters (D) with refractive astigmatism under -0.75 D) underwent SMILE in order to correct myopic error. In vivo evaluation was done by corneal confocal microscopy (IVCM) and ex vivo by immunohistochemistry...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27906736/an-exploratory-descriptive-study-of-registered-nurse-innovation-implications-for-levels-of-adoption
#3
Debra Polster, Dana Villines
PURPOSE: The aims of this study were to describe registered nurses' levels of personal innovativeness and registered nurses' perceived organizational innovativeness and determine the relationship between these 2 variables. BACKGROUND: There is limited research to describe the levels of innovation of nurses within a hospital. The levels of innovation can determine the likelihood of adoption of evidence-based practices at the bedside. As change agents, clinical nurse specialists can determine successful implementation strategies tailored to nurse levels of innovation...
January 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/27904248/percutaneous-cholecystostomy-evidence-based-current-clinical-practice
#4
REVIEW
Karan Gulaya, Shamit S Desai, Kent Sato
The role of percutaneous cholecystostomy (PC) in the management of acute cholecystitis and cholangitis is outlined in the revised 2013 Tokyo Guidelines. These two emergencies constitute the vast majority of PC performed today for therapeutic purposes, and research has repeatedly shown the utility of PC in these conditions. PC is typically employed in the management of critically ill patients who are not surgical candidates. Indications and contraindications to PC are reviewed. Additional innovative applications of PC have been developed since it was first described in 1980...
December 2016: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/27902591/a-novel-indication-for-a-method-in-the-treatment-of-lumbar-tuberculosis-through-minimally-invasive-extreme-lateral-interbody-fusion-xlif-in-combination-with-percutaneous-pedicle-screws-fixation-in-an-elderly-patient-a-case-report
#5
Qiyou Wang, Yichun Xu, Ruiqiang Chen, Jianwen Dong, Bin Liu, Limin Rong
RATIONALE: To describe a novel indication for a method through minimally invasive extreme lateral interbody fusion (XLIF) in combination with percutaneous pedicle screwsfixation in the treatment of lumbar tuberculosis (TB) in an elderly patient, and its clinical efficacy and feasibility. Lumbar TB is a destructive form of TB. Antituberculous treatment should be started as early as possible. In some circumstances, however, surgical debridement with or without stabilization of the spine appears to be beneficial and may be recommended...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27898468/update-on-ciliary-body-laser-procedures
#6
Behzad Amoozgar, Eileen N Phan, Shan C Lin, Ying Han
PURPOSE OF REVIEW: There are currently various options available for glaucoma treatment procedures ranging from laser to penetrating to nonpenetrating surgeries. Innovations in glaucoma surgical therapeutics include features such as external application, focused tissue effects, and minimal manipulation as these factors all help lower the risk of side-effects in addition to increasing the success rate of the treatment. Traditional diode laser transscleral cyclophotocoagulation (TSCPC) is invasive and destructive...
November 25, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27898467/an-update-on-therapeutic-modalities-for-the-prevention-of-angle-closure-glaucoma
#7
Behzad Amoozgar, Sasan Moghimi, Ying Han, Shan C Lin
PURPOSE OF REVIEW: Angle closure glaucoma is a prominent burden for the worldwide health system. Because this disorder is commonly asymptomatic, and can lead to irreversible blindness, the proper screening and early management of this disease can be critical. The definitions of angle closure and consequently its treatment guidelines have been dynamically modified and updated in the past decades. Surgical and laser techniques have been adapted to address the different mechanisms involved in the manifestation of the disease and properly prevent its progression in different stages...
November 25, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27896153/a-minor-innovation-in-constructing-a-small-bowel-stoma-in-neonates-with-small-bowel-atresia-to-reduce-the-morbidity
#8
Naeem Khan, Saba Bakht, Nadia Zaheer
BACKGROUND: Intestinal atresia has still significant morbidity in developing countries. Stomas are now not recommended in every case of intestinal atresia; primary anastomosis is the goal of surgery after resection of dilated adynamic gut. A new type of stoma formation along with primary anastomosis is being presented here. MATERIALS AND METHODS: This report is based on our experience of many cases with this technique in last 12 years but all the details and long follow-up of each case is not available...
October 2016: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/27895342/innovations-in-cardiovascular-care-historical-perspective-contemporary-practice-recent-trends-and-future-directions
#9
Hasanat Sharif, Mayera Tufail
Cardiovascular diseases continue to be a major cause of mortality and morbidity in the world population. First open heart procedure was performed by Gibbon in 1953, since then many advancements have been introduced to the field of cardiac surgery. Minimally invasive techniques were introduced, which include minimally invasive coronary artery bypass grafting (CABG), off-pump technique, minimally invasive valve surgery or transcatheter techniques to implant stentless or sutureless valves. The hybrid strategy to address coronary disease combines catheterisation procedures with standard surgical techniques...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27894610/-reconstruction-of-proximal-nasal-defect-after-deep-carcinological-resection-interest-to-combine-titane-mesh-with-fat-grafting
#10
R Aimard, C Lalloué, C Ho Quoc, D Girodet, P Zrounba, E Delay
INTRODUCTION: The mucosal cylindroma or adenoid cystic carcinoma is the second sinonasal non-epithelial malignant tumor frequency argument. Due to the achievement of the nasal mucosa and a late diagnosis reconstructions are often complex. We report the case of a mucous cylindroma recurrence of nasal septum requiring a wide and deep excision of the root of the nose with nasal reconstruction. CASE REPORT: A patient aged 66 years whose history resection two years ago with a mucous adenoid cystic carcinoma of the right side of the nasal septum, had a local recurrence T2NOM0 imposing a wide excision with amputation nasal septum own bones of nose, the anterior portion of the triangular cartilages...
November 25, 2016: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/27894030/fatigue-in-hospital-nurses-supernurse-culture-is-a-barrier-to-addressing-problems-a-qualitative-interview-study
#11
Linsey M Steege, Jessica G Rainbow
BACKGROUND: Fatigue in hospital nurses is associated with decreased nurse satisfaction, increased turnover and negative patient outcomes. Addressing fatigue in nurses has been identified as a priority by many organizations worldwide in an effort to promote both a culture of patient safety and a healthy nursing workforce. OBJECTIVES: The overall aim of this study was to explore barriers and facilitators within the hospital nurse work system to nurse coping and fatigue...
November 21, 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/27890315/global-surgery-a-view-from-the-south
#12
REVIEW
Nobhojit Roy
: This article is based on the Hugh Greenwood Lecture delivered at the 2016 Congress of the British Association of Paediatric Surgeons. It presents the view of the global surgery movement from the bottom of the surgical food chain and proposes what HICs (high-income countries) can do for global surgery in a coordinated fashion. From the LMIC (low- and middle-income countries) surgeon perspective, global surgery is transitioning from the charity-based surgery model to codevelopment with multiple stakeholders...
November 12, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27888865/advances-in-gastrointestinal-bleeding
#13
Ángel Lanas
The main innovations of the latest meeting of the Gastroenterological Association (2016) concerning upper gastrointestinal bleeding from the clinician's perspective can be summarised as follows: a) The Glasgow-Blatchford scale has the best accuracy in predicting the need for surgical intervention and hospital mortality; b) Prognostic scales for non-variceal upper gastrointestinal bleeding are also useful for lower gastrointestinal bleeding; c) Preliminary data suggest that treatment with hemospray does not seem to be superior to current standard treatment in controlling active peptic ulcer bleeding; d) Either famotidine or a proton pump inhibitor may be effective in preventing haemorrhagic recurrence in patients taking aspirin, but this finding needs to be confirmed in further studies; e) There was confirmation of the need to re-introduce antiplatelet therapy as early as possible in patients with antiplatelet-associated gastrointestinal bleeding in order to prevent cardiovascular mortality; f) Routine clinical practice suggests that gastrointestinal or cardiovascular complications with celecoxib or traditional NSAIDs are very low; g) Dabigatran is associated with an increased incidence of gastrointestinal bleeding compared with apixaban or warfarin...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27886971/the-feasibility-of-real-time-intraoperative-performance-assessment-with-simpl-system-for-improving-and-measuring-procedural-learning-early-experience-from-a-multi-institutional-trial
#14
REVIEW
Jordan D Bohnen, Brian C George, Reed G Williams, Mary C Schuller, Debra A DaRosa, Laura Torbeck, John T Mullen, Shari L Meyerson, Edward D Auyang, Jeffrey G Chipman, Jennifer N Choi, Michael A Choti, Eric D Endean, Eugene F Foley, Samuel P Mandell, Andreas H Meier, Douglas S Smink, Kyla P Terhune, Paul E Wise, Nathaniel J Soper, Joseph B Zwischenberger, Keith D Lillemoe, Gary L Dunnington, Jonathan P Fryer
PURPOSE: Intraoperative performance assessment of residents is of growing interest to trainees, faculty, and accreditors. Current approaches to collect such assessments are limited by low participation rates and long delays between procedure and evaluation. We deployed an innovative, smartphone-based tool, SIMPL (System for Improving and Measuring Procedural Learning), to make real-time intraoperative performance assessment feasible for every case in which surgical trainees participate, and hypothesized that SIMPL could be feasibly integrated into surgical training programs...
November 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27885165/neoadjuvant-chemotherapy-in-breast-cancers
#15
REVIEW
Shahla Masood
With advances in science and technology, there are more innovations in the approach to management of patients with breast cancer. Neoadjuvant chemotherapy that is designed to be used prior to surgical removal of a tumor has received significant attention. Currently, neoadjuvant chemotherapy is offered to patients with locally advanced breast cancer and also those breast cancer patients who may benefit from size reduction before conservation therapy. There is now sufficient evidence that if neoadjuvant chemotherapy leads to complete pathologic response, the patient will enjoy a better outcome...
September 2016: Women's Health
https://www.readbyqxmd.com/read/27884484/ross-hybrid-arch-and-frozen-elephant-trunk-reconstruction-for-late-complications-of-bicuspid-aortic-valve-and-aortopathy
#16
Matthew Valdis, Gaetano DeRose, Linrui Guo, Michael W A Chu
Young patients with bicuspid aortic valve disease and aortopathy remain a clinical challenge, with many requiring multiple corrective operations throughout their lifetimes. Innovative surgical approaches are often required to address complex aortic pathologic conditions but leave patients at risk for reintervention, lifelong anticoagulation, and suboptimal hemodynamics. We describe an active 44-year-old female triathlete with recurrent bicuspid aortic stenosis, a small aortic root, a hypoplastic aortic arch and complex distal arch, and a descending aortic aneurysm, who underwent a single-stage reconstruction with a combined Ross procedure, hybrid arch, and frozen elephant trunk reconstruction...
December 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27881055/patents-in-nanobiotechnology-a-cross-jurisdictional-approach
#17
Padmavati Manchikanti, Shailaja Gnaneshwar, B Ramesh Kumar
BACKGROUND: Bio nanomaterials create new opportunities for advancing medical sciences and diseases treatment in relation to human health care. Innovations in the use of such nanomaterials and nanodevices can lead to significant improvements in the use of drugs/devices. OBJECTIVE: The present study attempts to analyse patenting trends in different areas and compare the patentability criteria and the disclosure norms for nanobiotechnology inventions in countries such as US, EU and India in the field of diagnostics and therapeutics...
November 22, 2016: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/27880987/assessing-surgical-research-at-the-teaching-hospital-level
#18
Kate E McBride, Jane M Young, Paul G Bannon, Michael J Solomon
BACKGROUND: To undertake a comprehensive needs assessment to determine the baseline of surgical research activity at a tertiary referral hospital in Sydney, Australia. METHOD: The comprehensive needs assessment comprised three components: a retrospective audit of the hospital ethics committee records to identify surgical research activity; a survey of all 17 surgical departments about the availability of 10 potential research resources and a survey of surgical staff to ascertain perceptions of research culture at the organizational, team and individual levels...
November 23, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27878458/totally-extraperitoneal-tep-bilateral-hernioplasty-using-the-single-site%C3%A2-robotic-da-vinci-platform-dv-ss-tep-description-of-the-technique-and-preliminary-results
#19
A Cestari, A C Galli, M N Sangalli, M Zanoni, M Ferrari, G Roviaro
PURPOSE: Laparoendoscopic single site totally extraperitoneal (TEP) hernia repair showed to be a feasible alternative to conventional laparoscopic hernia repair; nevertheless single site surgery, with the loss of instruments triangulation can be a demanding procedure. To overcome those hurdles, the Single Site® (SS) platform of the da Vinci (DV) Si robotic system enables to perform surgical procedures through a 25-mm skin incision, with a stable 3D vision and restoring an adequate triangulation of the surgical instruments...
November 22, 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/27872012/biomimetic-collagen-elastin-meshes-for-ventral-hernia-repair-in-a-rat-model
#20
Silvia Minardi, Francesca Taraballi, Xin Wang, Fernando J Cabrera, Jeffrey L Van Eps, Andrew B Robbins, Monica Sandri, Michael R Moreno, Bradley K Weiner, Ennio Tasciotti
: Ventral hernia repair remains a major clinical need. Herein, we formulated a type I collagen/elastin crosslinked blend (CollE) for the fabrication of biomimetic meshes for ventral hernia repair. To evaluate the effect of architecture on the performance of the implants, CollE was formulated both as flat sheets (CollE Sheets) and porous scaffolds (CollE Scaffolds). The morphology, hydrophylicity and in vitro degradation were assessed by SEM, water contact angle and differential scanning calorimetry, respectively...
November 18, 2016: Acta Biomaterialia
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