Tipu Khan, Mariyam Almas, Nargis Malik, Akansha Jalota, Shaifali Sharma, Sk Asif Ali, Kalpana Luthra, Vaishali Suri, Ashish Suri, Soumen Basak, Pankaj Seth, Kunzang Chosdol, Subrata Sinha
STAT1 (Signal Transducer and Activator of Transcription 1), belongs to the STAT protein family, essential for cytokine signaling. Ithas been reported to have either context dependent oncogenic or tumor suppressor roles in different tumors. Earlier, we demonstrated that Glioblastoma multiforme (GBMs) overexpressing FAT1, an atypical cadherin, had poorer outcomes. Overexpressed FAT1 promotes pro-tumorigenic inflammation, migration/invasion by downregulating tumor suppressor gene, PDCD4. Here, we demonstrate that STAT1 is a novel mediator downstream to FAT1, in downregulating PDCD4 in GBMs...
April 17, 2024: Cellular Signalling