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Autistic spectrum disorder

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https://www.readbyqxmd.com/read/29790776/oral-health-challenges-facing-dubai-children-with-autism-spectrum-disorder-at-home-and-in-accessing-oral-health-care
#1
D Mansoor, M Al Halabi, A H Khamis, M Kowash
AIM: To investigate the challenges faced by Autism Spectrum Disorder (ASD) children and their families in Dubai from three different perspectives of dental care: oral care at home, oral care at the dentist and access to oral care, and to compare the results to their normally developing peers. MATERIALS AND METHODS: A case-control comparative study of 84 ASD and 53 healthy children attending special needs centres and schools in Dubai including siblings of the autistic children...
June 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29783181/autistic-traits-in-epilepsy-models-why-when-and-how
#2
REVIEW
Jana Velíšková, Jill L Silverman, Melissa Benson, Pierre-Pascal Lenck-Santini
Autism spectrum disorder (ASD) is a common comorbidity of epilepsy and seizures and/or epileptiform activity are observed in a significant proportion of ASD patients. Current research also implies that autistic traits can be observed to a various degree in mice and rats with seizures. This suggests that there are shared mechanisms in both ASD and epilepsy syndromes. Here, we first review the standard, validated methods used to assess autistic traits in animal models as well as their limitations with regards to epilepsy models...
May 18, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29782990/a-certain-role-of-sod-cat-imbalance-in-pathogenesis-of-autism-spectrum-disorders
#3
Konstantin Yenkoyan, Hayk Harutyunyan, Aida Harutyunyan
The real impact of reactive oxygen species, antioxidant enzymes, mitochondrial dysfunction and chronic inflammation on the development of autism spectrum disorders (ASD) remains unclear, and even controversial. In this study we compared the plasma levels of antioxidant enzymes and their cofactors, markers of oxidative damage, and the respiratory burst in peripheral blood polymorphonuclear leukocytes (PMNL) as surrogate marker of chronic inflammation obtained from 10 children (4-10 year old) who met DSM-5 criteria and their siblings...
May 18, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29778301/behavioral-coping-plans-one-inter-professional-team-s-approach-to-patient-centered-care
#4
Katherine Wittling, Jessica Palumbo Dufur, Ashley McClain, Margaret Gettis
BACKGROUND: Surgical encounters for children with Autism Spectrum Disorder (ASD) are stressful to patients, families and health care providers. It is recognized that parents best anticipate needs of children with ASD. Including a family in the plan of care for the child is imperative. In response to the need for targeted, tailored care, an inter-professional surgical services team convened to determine best practices for addressing a behavioral and developmental plan for children with ASD in the surgical services arena...
May 17, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29761934/assessing-the-heterogeneity-of-autism-spectrum-symptoms-in-a-school-population
#5
Paula Morales-Hidalgo, Pere J Ferrando, Josefa Canals
The aim of the present study was to assess whether the nature of the main autistic features (i.e., social communication problems and repetitive and restrictive patterns) are better conceptualized as dimensional or categorical in a school population. The study was based on the teacher ratings of two different age groups: 2,585 children between the ages of 10 and 12 (Primary Education; PE) and 2,502 children between the ages of 3 and 5 (Nursery Education; NE) from 60 mainstream schools. The analyses were based on Factor Mixture Analysis, a novel approach that combines dimensional and categorical features and prevents spurious latent classes from appearing...
May 15, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29761862/cellular-stress-and-apoptosis-contribute-to-the-pathogenesis-of-autism-spectrum-disorder
#6
Daoyin Dong, Horst Ronald Zielke, David Yeh, Peixin Yang
The molecular pathogenesis of autism spectrum disorder, a neurodevelopmental disorder, is still elusive. In this study, we investigated the possible roles of endoplasmic reticulum (ER) stress, oxidative stress, and apoptosis as molecular mechanisms underlying autism. This study compared the activation of ER stress signals (protein kinase R-like endoplasmic reticulum kinase [PERK], activating transcription factor 6 [ATF6], inositol-requiring enzyme 1 alpha [IRE1α]) in different brain regions (prefrontal cortex, hippocampus, cerebellum) in subjects with autism and in age-matched controls...
May 15, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29757142/autistic-traits-but-not-schizotypy-predict-increased-weighting-of-sensory-information-in-bayesian-visual-integration
#7
Povilas Karvelis, Aaron R Seitz, Stephen M Lawrie, Peggy Seriès
Recent theories propose that schizophrenia/schizotypy and autistic spectrum disorder are related to impairments in Bayesian inference i.e. how the brain integrates sensory information (likelihoods) with prior knowledge. However existing accounts fail to clarify: i) how proposed theories differ in accounts of ASD vs. schizophrenia and ii) whether the impairments result from weaker priors or enhanced likelihoods. Here, we directly address these issues by characterizing how 91 healthy participants, scored for autistic and schizotypal traits, implicitly learned and combined priors with sensory information...
May 14, 2018: ELife
https://www.readbyqxmd.com/read/29753726/two-single-nucleotide-polymorphisms-of-the-reln-gene-and-symptom-based-and-developmental-deficits-among-children-and-adolescents-with-autistic-spectrum-disorders-in-the-tianjin-china
#8
Geng-Fu Wang, Sheng Ye, Lei Gao, Yu Han, Xuan Guo, Xiao-Peng Dong, Yuan-Yuan Su, Xin Zhang
Increasing evidence has revealed that genetic variants in Reelin (RELN) gene, especially single-nucleotide polymorphisms (SNPs), correlate with autistic spectrum disorders (ASD) risk; however, no consensus have been reached. This study aimed to provide additional evidence for the association between two SNPs of RELN (i.e., rs736707, rs2229864) and ASD risk, as well as the relationship between RELN gene and symptom-based and developmental deficits of ASD patients in Chinese Han children and adolescents. 157 ASD subjects and 256 typical development (TD) controls were genotyped by TaqMan® genotyping assay...
May 10, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29753322/clinical-outcomes-of-interactive-intensive-and-individual-3i-play-therapy-for-children-with-asd-a-two-year-follow-up-study
#9
Elodie Tilmont Pittala, Yann Saint-Georges-Chaumet, Claire Favrot, Antoine Tanet, David Cohen, Catherine Saint-Georges
BACKGROUND: The outcomes of psycho-educational interventions for Autism Spectrum Disorders (ASDs) comorbid with severe to moderate intellectual disability (ID) are insufficiently documented. In this prospective study, we examined a developmental individual, interactive and intensive approach, called the '3i method', which is based on play therapy. METHODS: Twenty DSM-IV-TR ASD subjects (mean chronological age 63.8 ± 37.8 months; mean developmental age 19.5 ± 6...
May 12, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29752661/tracking-the-influence-of-autistic-traits-on-competencies-among-school-aged-children-with-subthreshold-autistic-traits-a-longitudinal-study
#10
Eileen T Crehan, Julie Baer, Robert R Althoff, John N Constantino
This study aims to further explore the implications of autism spectrum disorder (ASD) symptoms for children who do not meet full diagnostic criteria. More specific characterization of how challenges present relative to traits of ASD such as social responsiveness is vital to developing an understanding of what competency and mental health difficulties these impairments are related to, and if they persist over time. Assessments of autistic traits, clinical symptomotology, and competency were used to quantify the relation of these domains cross-sectionally and across time...
May 11, 2018: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29742462/the-link-between-interoceptive-processing-and-anxiety-in-children-diagnosed-with-autism-spectrum-disorder-extending-adult-findings-into-a-developmental-sample
#11
E R Palser, A Fotopoulou, E Pellicano, J M Kilner
Anxiety is a major associated feature of autism spectrum disorders. The incidence of anxiety symptoms in this population has been associated with altered interoceptive processing. Here, we investigated whether recent findings of impaired interoceptive accuracy (quantified using heartbeat detection tasks) and exaggerated interoceptive sensibility (subjective sensitivity to internal sensations on self-report questionnaires) in autistic adults, can be extended into a school-age sample of children and adolescents (n = 75)...
May 6, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29742331/youth-with-autism-spectrum-disorder-in-the-emergency-department
#12
Sarah Lytle, Andrew Hunt, Sonal Moratschek, Marcie Hall-Mennes, Martha Sajatovic
OBJECTIVE: This comprehensive literature review summarizes reports on emergency department (ED) use by youth with autism spectrum disorder (ASD). DATA SOURCES: We conducted a systematic search of the PubMed, PsycINFO, CINAHL, and EMBASE databases (1985-2016), limited to studies published in English. The following search terms were used: autism, autistic, Asperger, emergency department/room/physician/doctor/treatment/medicine, childhood developmental disorders (pervasive), and emergencies...
May 8, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29739549/progress-in-the-usa-for-autistic-spectrum-disorder
#13
EDITORIAL
The Lancet
No abstract text is available yet for this article.
May 5, 2018: Lancet
https://www.readbyqxmd.com/read/29738079/patients-with-chronic-fatigue-syndrome-do-not-score-higher-on-the-autism-spectrum-quotient-than-healthy-controls-comparison-with-autism-spectrum-disorder
#14
Indre Bileviciute-Ljungar, Daniel Maroti, Susanne Bejerot
Clinically, there is an overlap of several symptoms of chronic fatigue syndrome (CFS) and autism spectrum disorder (ASD), including fatigue; brain "fog"; cognitive impairments; increased sensitivity to sound, light, and odour; increased pain and tenderness; and impaired emotional contact. Adults with CFS (n = 59) or ASD (n = 50) and healthy controls (HC; n = 53) were assessed with the Autism-Spectrum Quotient (AQ) in a cross-sectional study. Non-parametric analysis was used to compare AQ scores among the groups...
May 8, 2018: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29737001/clinical-and-functional-characterization-of-two-novel-zbtb20-mutations-causing-primrose-syndrome
#15
Emilia Stellacci, Katharina Steindl, Pascal Joset, Laura Mercurio, Massimiliano Anselmi, Serena Cecchetti, Laura Gogoll, Markus Zweier, Annette Hackenberg, Gianfranco Bocchinfuso, Lorenzo Stella, Marco Tartaglia, Anita Rauch
Primrose syndrome (PS) is a rare disorder characterized by macrocephaly, tall stature, intellectual disability, autistic traits, and disturbances of glucose metabolism with insulin-resistant diabetes and distal muscle wasting occurring in adulthood. The disorder is caused by functional dysregulation of ZBTB20, a transcriptional repressor controlling energetic metabolism and developmental programs. ZBTB20 maps in a genomic region that is deleted in the 3q13.31 microdeletion syndrome, which explains the clinical overlap between the two disorders...
May 7, 2018: Human Mutation
https://www.readbyqxmd.com/read/29731598/broader-autism-phenotype-in-parents-of-children-with-autism-a-systematic-review-of-percentage-estimates
#16
Eric Rubenstein, Devika Chawla
The broader autism phenotype (BAP) is a collection of sub-diagnostic autistic traits more common in families of individuals with autism spectrum disorder (ASD) than in the general population. BAP is a latent construct that can be defined using different domains, measured using multiple instruments, and reported using different techniques. Therefore, estimates of BAP may vary greatly across studies. Our objective was to systematically review studies that reported occurrence of BAP in parents of children with ASD in order to quantify and describe heterogeneity in estimates...
June 2018: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/29731309/trace-element-levels-are-associated-with-neuroinflammatory-markers-in-children-with-autistic-spectrum-disorder
#17
Anatoly V Skalny, Natalia V Simashkova, Anastasia A Skalnaya, Tatiana P Klyushnik, Irina V Zhegalova, Andrei R Grabeklis, Margarita G Skalnaya, Alexey A Tinkov
The objective of the present study was to estimate the association between brain inflammatory markers and serum trace element levels as assessed by inductively coupled plasma mass spectrometry at NexION 300D. Leukocyte elastase (LE), α1-proteinase inhibitor (α1-PI) activity, anti-nerve growth factor-antibodies (anti-NGF-Ab), and anti-myelin basic protein-antibodies (anti-MBP-Ab) levels were assessed as inflammatory markers. The obtained data demonstrate that the increase in LE and α1-PI activity is associated with higher serum Cr and Cu levels, respectively...
April 27, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29717186/novel-nexmif-pathogenic-variant-in-a-boy-with-severe-autistic-features-intellectual-disability-and-epilepsy-and-his-mildly-affected-mother
#18
Nelle Lambert, Corinne Dauve, Emmanuelle Ranza, Periklis Makrythanasis, Federico Santoni, Frédérique Sloan-Béna, Stefania Gimelli, Jean-Louis Blouin, Michel Guipponi, Armand Bottani, Stylianos E Antonarakis, Markus M Kosel, Joel Fluss, Ariane Paoloni-Giacobino
Intellectual disability (ID) and autism spectrum disorders are complex neurodevelopmental disorders occurring among all ethnic and socioeconomic groups. Pathogenic variants in the neurite extension and migration factor (NEXMIF) gene (formerly named KIAA2022) on the X chromosome are responsible for ID, autistic behavior, epilepsy, or dysmorphic features in males. Most affected females described had a milder phenotype or were asymptomatic obligate carriers. We report here for the first time mother-to-son transmission of a novel NEXMIF truncating variant without X-inactivation skewing in the blood...
May 1, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29706160/autistic-traits-and-suicidal-thoughts-plans-and-self-harm-in-late-adolescence-population-based-cohort-study
#19
Iryna Culpin, Becky Mars, Rebecca M Pearson, Jean Golding, Jon Heron, Isidora Bubak, Peter Carpenter, Cecilia Magnusson, David Gunnell, Dheeraj Rai
OBJECTIVE: To examine the hypothesis that autism spectrum disorders (ASD) diagnosis and traits in childhood are associated with suicidal thoughts, plans and self-harm at 16 years, and that any observed associations are explained by depression at 12 years. METHOD: We examined associations between ASD diagnosis and 4 dichotomized ASD traits (social communication, pragmatic language, repetitive behavior, and sociability) with suicidal and nonsuicidal self-harm, suicidal thoughts, and suicidal plans at age 16 years in 5,031 members of the United Kingdom-based birth cohort study the Avon Longitudinal Study of Parents and Children...
May 2018: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29704141/2d-4d-ratio-in-neurodevelopmental-disorders-a-twin-study
#20
Lynnea Myers, Annelies Van't Westeinde, Ralf Kuja-Halkola, Kristiina Tammimies, Sven Bölte
The second to fourth digit (2D:4D) ratio is of interest in autism spectrum disorder (ASD). Studies on the relationship of this ratio with other neurodevelopmental disorders (NDDs) are lacking. Investigating the association between the ratio and NDDs in twins can provide insight into genetic and/or environmental factors driving the ratio. Hand images were collected in N = 238 twins with NDDs or typical development from 70 monozygotic and 49 dizygotic pairs to examine ratios and their associations to DSM-5 defined categorical NDDs, autistic traits, zygosity, and sex...
April 27, 2018: Journal of Autism and Developmental Disorders
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