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https://www.readbyqxmd.com/read/29156624/evaluation-of-posaconazole-pharmacokinetics-in-adult-patients-with-invasive-fungal-infection
#1
Sarah Allegra, Giovanna Fatiguso, Silvia De Francia, Fabio Favata, Elisa Pirro, Chiara Carcieri, Amedeo De Nicolò, Jessica Cusato, Giovanni Di Perri, Antonio D'Avolio
Mortality and morbidity due to invasive fungal infections have increased over the years. Posaconazole is a second-generation triazole agent with an extended spectrum of activity, which shows a high interindividual variability in its plasma levels, rendering dosing in many patients inconsistent or inadequate. Hence, posaconazole therapeutic drug monitoring, which is easily available in clinical practice, may improve treatment success and safety. The aim of the study was to describe posaconazole pharmacokinetics, and to evaluate the utility of therapeutic drug monitoring for therapy and prophylaxis in a cohort of adult patients...
November 20, 2017: Biomedicines
https://www.readbyqxmd.com/read/29156508/validity-and-reliability-of-the-turkish-version-of-the-readiness-for-hospital-discharge-scale-short-form
#2
Sıdıka Kaya, Gulay Sain Guven, Mesut Teleş, Cahit Korku, Seda Aydan, Ahmet Kar, Nazan Kartal, Gülsüm Şeyma Koca, Ahmet Yıldız
AIM: The aim of this study is to test the validity and reliability of the Turkish version of the readiness for hospital discharge scale/short form. BACKGROUND: Assessment of readiness for discharge from the patient's perspective is becoming increasingly important for patient safety, satisfaction and various patient outcomes such as readmission, health service utilization and mortality. The readiness for hospital discharge scale/short form allows health care providers to determine patients' discharge readiness...
November 20, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/29155842/posterior-column-acetabular-fracture-fixation-using-a-w-shaped-angular-plate-a-biomechanical-analysis
#3
Ke Su, Song Liu, Tao Wu, Yingchao Yin, Ruipeng Zhang, Shilun Li, Yingze Zhang
OBJECTIVE: The purpose of this study was to compare the stability and feasibility of four fixation constructs in a posterior column acetabular fracture: one reconstruction plate, one reconstruction plate and lag screw, two reconstruction plates, and a W-shaped acetabular angular plate. METHODS: Twenty embalmed cadaveric pelvises with a posterior column acetabular fractures were allocated to one of four groups: 1) a reconstruction plate, 2) a reconstruction plate with a posterior column lag screw, 3) double reconstruction plates, and 4) a W-shaped acetabular angular plate...
2017: PloS One
https://www.readbyqxmd.com/read/29155739/standardized-method-for-high-throughput-sterilization-of-arabidopsis-seeds
#4
Benson E Lindsey, Luz Rivero, Chistopher S Calhoun, Erich Grotewold, Jelena Brkljacic
Arabidopsis thaliana (Arabidopsis) seedlings often need to be grown on sterile media. This requires prior seed sterilization to prevent the growth of microbial contaminants present on the seed surface. Currently, Arabidopsis seeds are sterilized using two distinct sterilization techniques in conditions that differ slightly between labs and have not been standardized, often resulting in only partially effective sterilization or in excessive seed mortality. Most of these methods are also not easily scalable to a large number of seed lines of diverse genotypes...
October 17, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155586/deconstructing-lipid-kinase-inhibitors-by-chemical-proteomics
#5
Rebecca L McCloud, Caroline E Franks, Sean T Campbell, Benjamin W Purow, Thurl E Harris, Ku-Lung Hsu
Diacylglycerol kinases (DGKs) regulate lipid metabolism and cell signaling through ATP-dependent phosphorylation of diacylglycerol to biosynthesize phosphatidic acid. Selective chemical probes to study DGKs are currently lacking and needed to annotate isoform-specific functions of these elusive lipid kinases. Previously, we explored fragment-based approaches to discover a core fragment of DGK-alpha (DGKα) inhibitors responsible for selective binding to the DGKα active site. Here, we utilize quantitative chemical proteomics to deconstruct widely used DGKα inhibitors to identify structural regions mediating off-target activity...
November 20, 2017: Biochemistry
https://www.readbyqxmd.com/read/29155060/controlling-cell-free-metabolism-through-physiochemical-perturbations
#6
Ashty S Karim, Jacob T Heggestad, Samantha A Crowe, Michael C Jewett
Building biosynthetic pathways and engineering metabolic reactions in cells can be time-consuming due to complexities in cellular metabolism. These complexities often convolute the combinatorial testing of biosynthetic pathway designs needed to define an optimal biosynthetic system. To simplify the optimization of biosynthetic systems, we recently reported a new cell-free framework for pathway construction and testing. In this framework, multiple crude-cell extracts are selectively enriched with individual pathway enzymes, which are then mixed to construct full biosynthetic pathways on the time scale of a day...
November 15, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/29155035/utility-of-anesthetic-block-for-endometrial-ablation-pain-a-randomized-controlled-trial
#7
Jordan S Klebanoff, Nima R Patel, Nancy L Sloan
BACKGROUND: Second-generation endometrial ablation has been demonstrated safe for abnormal uterine bleeding treatment in premenopausal women, who have completed childbearing, in short-stay surgical centers and in physicians' offices. However, no standard regarding anesthesia exists and practice varies depending on physician or patient preference and hospital policy and setting. OBJECTIVE: To evaluate whether local anesthetic, in combination with general anesthesia, affects postoperative pain and associated narcotic use following endometrial ablation...
November 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29154971/preemptive-anticoagulation-of-patients-with-a-high-pretest-probability-of-pulmonary-embolism-are-guidelines-followed
#8
Laura Willoughby, Daniel M Adams, R Scott Evans, James F Lloyd, Scott M Stevens, Scott C Woller, Joseph R Bledsoe, Valerie T Aston, Emily L Wilson, C Gregory Elliott
BACKGROUND: Guidelines suggest anticoagulation of patients with high pretest probability of pulmonary embolism (PE) while awaiting diagnostic test results (preemptive anticoagulation). Data relevant to the practice of preemptive anticoagulation are not available. METHODS: We reviewed 3,500 consecutive patients who underwent CT pulmonary angiography (CTPA) at 2 emergency departments (ED). We classified the pretest probability for PE using the Revised Geneva Score (RGS) as low (RGS 0-3), intermediate (RGS 4-10), or high (RGS 11-18)...
November 15, 2017: Chest
https://www.readbyqxmd.com/read/29154965/noninvasive-assessment-of-nonalcoholic-fatty-liver-disease-clinical-prediction-rules-and-blood-based-biomarkers
#9
REVIEW
Eduardo Vilar-Gomez, Naga Chalasani
The correct identification of patients at increased risk of non-alcoholic steatohepatitis (NASH) and advanced fibrosis is a critical step in the assessment of NAFLD. Since liver biopsy is invasive, expensive and prone to sampling error, several clinical prediction rules and blood-based biomarkers have been developed as an attractive and affordable alternatives to guide clinicians to identify patients at high risk of NASH and advanced fibrosis. Current biomarkers constitute predictive models (e.g., NAFLD fibrosis score, FIB-4 index and BARD score) or direct measures of inflammation (e...
November 14, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29154893/an-interleaved-sequence-for-simultaneous-magnetic-resonance-angiography-mra-susceptibility-weighted-imaging-swi-and-quantitative-susceptibility-mapping-qsm
#10
Yongsheng Chen, Saifeng Liu, Sagar Buch, Jiani Hu, Yan Kang, E Mark Haacke
PURPOSE: To image the entire vasculature of the brain with complete suppression of signal from background tissue using a single 3D excitation interleaved rephased/dephased multi-echo gradient echo sequence. This ensures no loss of signal from fast flow and provides co-registered susceptibility weighted images (SWI) and quantitative susceptibility maps (QSM) from the same scan. MATERIALS AND METHODS: The suppression of background tissue was accomplished by subtracting the flow-dephased images from the flow-rephased images with the same echo time of 12...
November 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29154850/motor-response-matters-optimizing-lead-placement-improves-sacral-neuromodulation-outcomes
#11
Javier Pizarro-Berdichevsky, Bradley C Gill, Marisa Clifton, Henry T Okafor, Anna E Faris, Sandip P Vasavada, Howard B Goldman
PURPOSE: To determine the utility of motor responses during Sacral Neuromodulation (SNM) lead placement by testing the hypothesis that a greater number of motor responses during intraoperative electrode testing is associated with more durable therapy. MATERIALS AND METHODS: A retrospective review of all SNM lead placements at a large academic center from 2010-2015 was performed. All unilateral sacral lead placements with the presence or absence of a motor response documented discretely for each electrode were included...
November 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29154612/alexithymia-is-associated-with-a-multidomain-multidimensional-failure-of-interoception-evidence-from-novel-tests
#12
Jennifer Murphy, Caroline Catmur, Geoffrey Bird
Interoception, the perception of the body's internal state, contributes to numerous aspects of higher-order cognition. Several theories suggest a causal role for atypical interoception in specific psychiatric disorders, including a recent claim that atypical interoception represents a transdiagnostic impairment across disorders characterized by reduced perception of one's own emotion (alexithymia). Such theories are supported predominantly by evidence from only one interoceptive domain (cardiac); however, evidence of domain-specific interoceptive ability highlights the need to assess interoception in noncardiac domains...
November 20, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/29154393/using-participatory-system-dynamics-modeling-to-examine-the-local-hiv-test-and-treatment-care-continuum-in-order-to-reduce-community-viral-load
#13
Margaret R Weeks, Jianghong Li, David Lounsbury, Helena Danielle Green, Maryann Abbott, Marcie Berman, Lucy Rohena, Rosely Gonzalez, Shawn Lang, Heather Mosher
Achieving community-level goals to eliminate the HIV epidemic requires coordinated efforts through community consortia with a common purpose to examine and critique their own HIV testing and treatment (T&T) care system and build effective tools to guide their efforts to improve it. Participatory system dynamics (SD) modeling offers conceptual, methodological, and analytical tools to engage diverse stakeholders in systems conceptualization and visual mapping of dynamics that undermine community-level health outcomes and identify those that can be leveraged for systems improvement...
November 20, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29154228/practical-prognostic-score-for-predicting-the-extent-of-resection-and-neurological-outcome-of-gliomas-in-the-sensorimotor-area
#14
Giannantonio Spena, Federico D'Agata, Pier Paolo Panciani, Luciano Buttolo, Michela Buglione di Monale Bastia, Marco Maria Fontanella
OBJECTIVE: In this prospective study, we assessed the utility of a novel prognostic score (PS) in guiding the surgical strategy of patients with sensorimotor area gliomas. PATIENTS AND METHODS: Form December 2012 to April 2016, we collected data from patients diagnosed with brain gliomas in the sensorimotor area. All the patients had intraoperatively confirmed contiguity or continuity with sensorimotor cortical and subcortical structures. Several clinical and radiological factors were analyzed to generate a PS for each patient (range 1-8)...
November 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29154206/a-new-approach-in-separating-microplastics-from-environmental-samples-based-on-their-electrostatic-behavior
#15
Stefanie Felsing, Christian Kochleus, Sebastian Buchinger, Nicole Brennholt, Friederike Stock, Georg Reifferscheid
Numerous studies on microplastics (MPs; Ø < 5 mm) in the aquatic environment have been published, but knowledge about the occurrence and ecological risks of MPs is limited. This is in part because current data on the distribution of MPs are comparable only to a limited extent, due to the many different methods of investigation. In addition, sample preparation is often difficult such that standard procedures are lacking. The aim of this work was to simplify the preparation of different kinds of MP samples...
November 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29153929/accuracy-of-a-simulation-algorithm-for-modelling-lv-contractility-diastolic-capacitance-and-energetics-using-data-available-from-common-hemodynamic-monitors-and-echocardiography
#16
Paul M Heerdt, Scott Korfhagen, Hesham Ezz, Clara Oromendia
OBJECTIVE: To test the hypothesis that a simulation algorithm populated with data readily available from hemodynamic monitors and echocardiography can accurately model cardiac contractility, diastolic capacitance, and energetics. DESIGN: Bland-Altman analysis of paired data sets. SETTING: University laboratory. PARTICIPANTS: Archived data previously recorded from 7 anesthetized swine. MEASUREMENTS AND MAIN RESULTS: Left ventricular pressure and volume (LVV) data that had been continuously recorded over a range of inotropic conditions were used as reference data...
September 27, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29153867/impact-of-upper-body-precooling-during-warm-up-on-subsequent-time-trial-paced-cycling-in-the-heat
#17
Charles P Katica, Jonathan E Wingo, Robert L Herron, Greg A Ryan, Stacy H Bishop, Mark Richardson
OBJECTIVES: The purpose of this study was to test the hypothesis that cooling the upper body during a warm-up enhances performance during a subsequent 16.1-km simulated cycling time trial in a hot environment. DESIGN: Counterbalanced, repeated measures design. METHODS: Eight trained, male cyclists (peak oxygen uptake=57.8±5.0mLkg(-1)min(-1)) completed two simulated 16.1-km time trials in a hot environment (35.0±0.5°C, 43.8±2.0% relative humidity) each separated by 72h...
October 16, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29153784/an-empirical-comparison-of-isolate-based-and-sample-based-definitions-of-antimicrobial-resistance-and-their-effect-on-estimates-of-prevalence
#18
R W Humphry, J Evans, C Webster, S C Tongue, G T Innocent, G J Gunn
Antimicrobial resistance is primarily a problem in human medicine but there are unquantified links of transmission in both directions between animal and human populations. Quantitative assessment of the costs and benefits of reduced antimicrobial usage in livestock requires robust quantification of transmission of resistance between animals, the environment and the human population. This in turn requires appropriate measurement of resistance. To tackle this we selected two different methods for determining whether a sample is resistant - one based on screening a sample, the other on testing individual isolates...
November 10, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29153522/short-communication-growth-of-dairy-isolates-of-geobacillus-thermoglucosidans-in-skim-milk-depends-on-lactose-degradation-products-supplied-by-anoxybacillus-flavithermus-as-secondary-species
#19
Y Zhao, M Kumar, M P M Caspers, M N Nierop Groot, J M B M van der Vossen, T Abee
Thermophilic bacilli such as Anoxybacillus and Geobacillus are important contaminants in dairy powder products. Remarkably, one of the common contaminants, Geobacillus thermoglucosidans, showed poor growth in skim milk, whereas significant growth of G. thermoglucosidans was observed in the presence of an Anoxybacillus flavithermus dairy isolate. In the present study, we investigated the underlying reason for this growth dependence of G. thermoglucosidans. Whole-genome sequences of 4 A. flavithermus strains and 4 G...
November 15, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29153444/retrospective-evaluation-of-piperacillin-tazobactam-imipenem-cilastatin-and-meropenem-used-on-surgical-floors-at-a-tertiary-care-hospital-in-saudi-arabia
#20
Eman Youssif, Mohammed Aseeri, Sahal Khoshhal
BACKGROUND: The appropriate use of broad-spectrum antibiotics, including appropriate de-escalation, is essential to reduce the emergence of antibiotic resistance. In surgical floors antibiotics are prescribed for prophylaxis (mostly, single dose), empirical treatment (started if infection is suspected till bacteria are identified with its sensitivity to antibiotics), or treatment of well-defined infection of previously isolated bacteria with its sensitivity to antibiotics. In this study, we aimed to evaluate the use of broad-spectrum antibiotics based on requests for cultures and de-escalation based on sensitivity results of culture tests at tertiary care hospital...
November 15, 2017: Journal of Infection and Public Health
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