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miocardial infarction

S Pascual-Gil, E Garbayo, P Díaz-Herráez, F Prosper, M J Blanco-Prieto
Myocardial infarction causes almost 7.3 million deaths each year worldwide. However, current treatments are more palliative than curative. Presently, cell and protein therapies are considered the most promising alternative treatments. Clinical trials performed until now have demonstrated that these therapies are limited by protein short half-life and by low transplanted cell survival rate, prompting the development of novel cell and protein delivery systems able to overcome such limitations. In this review we discuss the advances made in the last 10years in the emerging field of cardiac repair using biomaterial-based delivery systems with focus on the progress made on preclinical in vivo studies...
April 10, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
Mauro Ferrante, Giovanni De Luca, Giovanna Fantaci, Sebastiano Pollina Addario, Salvatore Scondotto
OBJECTIVES: to analyse the effect of distance between the Municipality of residence and the nearest hospital on out-of-hospital mortality rate of patients died for acute myocardial infarction (AMI). DESIGN: analysis of out-of-hospital mortality using a record linkage database. SETTING AND PARTICIPANTS: Sicilian Municipalities; 4,999 deaths with acute myocardial infarction as primary cause of death, by excluding patients hospitalised within the 15 days before the death event...
November 2014: Epidemiologia e Prevenzione
Angela Bento, João Vasconcelos, Carlos Aguiar, Agostinho Caeiro, António Jara
The development of troponins dramatically changed the diagnosis of cardiac injury. Cardiac troponins are the most sensitive and specific biochemical markers of myocardial damage. In 2000. it was elaborated the new definition of miocardial infarction that reflected the importance of that biomarker. The rationale of including troponin assay in the diagnosis pathway was based on the assumption that myocardial necrosis, regardless of its magnitude, should be characterized as myocardial infarction. However, if the patient's clinical picture do no match an elevated troponin result we shoud suspect a false positive value caused by analytical interferences...
September 2010: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Nicoletta Biglia, Silvia Maffei, Stefano Lello, Rossella E Nappi
AIM: To critically discuss the use of tibolone (T), in light of a series of very recent double-blind placebo (PL) controlled trials (LISA, LIFT, OPAL, THEBES, LIBERATE) conducted worldwide in a large number of postmenopausal women (PMW). METHODS: The most relevant publications on T therapy in PMW were considered with emphasis on menopausal symptoms, quality of life, sexuality, bone, cardiovascular system (CVS) and oncologic risk. RESULTS: T significantly relieves climacteric symptoms and improves mood and sexual well-being (LISA)...
November 2010: Gynecological Endocrinology
Cecilia Mihalcea, G I Pandele
UNLABELLED: Chronic myocardial infarction represents one of the most important problems of actual clinical medicine because their incidence is growing especially at young adults (< 45 years) and their mortality with no treatment is high in first month after acute myocardial infarction (50%). When cardiovascular disease is associated with diabetes mellitus, evolution of patients is more serious. AIM: To compare the disease evolution for two groups of patients--one with patients who have purely chronic myocardial infarction and other with patients who have chronic myocardial infarction associated with glycoregulation disturbances (diabetes mellitus, impaired glucose tolerance or impaired fasting glucose)...
July 2009: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
G V Abuladze, M I Nevieridze, R I Abashidze, L V Gabarashvili, A A Kvirkveliia
Sudden cardiac death (SCD) - this natural death caused by cardiac reasons and which is characterized by sudden loss of consciousness within first hour after revealing of sharp clinical symptoms. A primary factor of SCD is not traumatic. It occurs suddenly and unexpectedly. The high risk of development of sudden cardiac death is basically associated with ventricular arrhythmias. Electrophysiological anomalies in cells lead to development of ventricular ectopic activity or ventricular tachycardia which comes to the end with fibrillation...
March 2009: Georgian Medical News
Carlos Rodolfo Martínez Sánchez, Jesús Octavio Martínez-Reding, Eulo Lupi Herrera
Cardiogenic shock (CHC) associated to acute myocardial infarct has high mortality and their manifestations are heterogenous. In our institution historical mortality, was 98%, but with different methods of reperfusion, its reduced to 53%. In other hand, with opportune clinical stratification is useful to improve the treatment strategy. This stratification on basis in clinical signs: age, infarction location, cardiac frequency and systemic arterial pressure, and hemodynamical valuation with the use of right catheterism with quantification miocardial work parameters like "Cardiac power" that is the product of flow and arterial pressure and that is of utility to know the "Miocardial reserve"...
April 2006: Archivos de Cardiología de México
Bogusław Okopień, Margin Basiak, Andrzej Madej, Krzysztof Labuzek, Dariusz Belowski, Maciej Haberka, Zbigniew Stanisław Herman
Clinical studies performed in last few years proved great role of inflammatory processes in development of atherosclerosis. Inflammatory markers indicating unstable atherosclerotic plaque were isolated. These biomarkers are used in diagnostics and identification of patients with unstable angina pectoris and miocardial infarct. Moreover usefulness of proinflammatory markers in indicating patients with high cardiovascular risk was confirmed. In result different markers of inflammation found their use in diagnostics of patients with stable and unstable coronary artery disease...
July 2006: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Joseph J Naoum, Hong Chai, Peter H Lin, Alan B Lumsden, Qizhi Yao, Changyi Chen
Inflammation plays an important role in atherosclerotic plaque formation, rupture and thrombogenicity. Many cytokines are the most important biomediates of inflammation and its associated vascular lesions. Lymphotoxin-alpha (LTalpha) is part of the tumor necrosis factor (TNF) family of cytokines that mediates an inflammatory or immunologic response that can affect cell death or differentiation, and provide an important link of communication between lymphocytes and stromal cells. Several genetic and clinical studies implicate LTalpha, and its binding and regulatory partner galectin-2, as a risk factor in the pathogenesis of cardiovascular diseases including miocardial infarction, aortic aneurysm, and cerebral infarction...
July 2006: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
V Grujić, J Dorde
By devoting World Health Day 1992 to the theme of heart health, it is the aim of the World Health Organization to increase public awareness of the worldwide dimensions of cardiovascular diseases, and to sound an alarm against their spread. Cardiovascular diseases are diseases of the highest social and medical importance. They are taking about 12 millions lives annually. Many victims are under the age of 65 years. Fortunatelly, many of the diseases could be prevented or postponed to the older age, as 3/4 of the cases are results of inadequate attitudes, knowledge, habits and behaviour...
1992: Medicinski Pregled
Mauro Frego, Giorgio Bianchera, Dimitrios Kontothanassis, Fabio Pilon, Giovanni Ambrosino, Loretta Di Cristofaro, Elisa Bonello, Diego Miotto, Claudio Fittà, Giuseppe Tropeano, Giulio Barbiero
Data from 30 consecutive excluded abdominal aortic aneurysms (AAA) have been analysed, to verify whether important morphological changes take place after exclusion, and whether these can be considered as risk factors for functional (leaks, flow alterations) and clinical complications (rupture, obstruction). All AAAs have been initially successfully excluded and patients have been followed up by clinical examinations and ct scan controls post-operatively, at the third and sixth month, then yearly. At a mean follow-up of 17 months, dimension of the proximal neck increased significantly (> 2 mm in diameter) in five pts and graft was distally dislodged in two...
2003: Acta Bio-medica: Atenei Parmensis
S V Shalaev, E V Metlitskaia, D V Teffenberg, N V Shanaurina, E S Petrik, S Iu Volkova
Patients with left ventricular ejection fraction below 45% (mean 39+/-3.7%) were randomized either to captopril (n=33) or eprosartan after miocardial infarction (n=33) on days 3-7 of myocardial infarction. All patients were subjected to echocardiography and 40 to perfusion myocardial scintigraphy with (99m)TC-Technetril. Myocardial viability was defined as presence of perfusion reserve in dysfunctional segments during test with nitroglycerin. Dysfunctional myocardium was found to be viable in 62.5% of patients...
2004: Kardiologiia
Marina Maggini, Stefania Spila Alegiani, Roberto Raschetti
A large multicenter cohort study, the DAI study, is being performed on patients with type 2 diabetes mellitus who are followed by diabetic care units in Italy, to study the prevalence and incidence of macrovascular complications. The reference population consists of all patients visited at the participating units in the period September 1998-June 1999. Patients were randomly chosen so as to create a sample representative of the diabetic population visited at the units. Overall, 201 Italian diabetic care units participated in the study and 19,570 patients were included in the study...
2003: Annali Dell'Istituto Superiore di Sanità
S López Alvarez, C Bonome González, B Izquierdo Villarroya, M J Barbeito Vilariño, A Etxainz Alvarez, F Alvarez Refojo
A 72-year-old man, smoker, with insuline-dependent diabetes and dislipemia underwent left pneumonectomy. Several episodes of intraoperative hemodynamic instability associated with electrocardiographic ST segment alterations were attributed to surgical manipulation; ischemia was not suspected. Cardiorespiratory failure, related to extensive anterior infarction, developed a few minutes after admission to the postoperative intensive care unit (PICU). Cardiopulmonary resuscitation and mechanical ventilation were required...
November 2002: Revista Española de Anestesiología y Reanimación
Yaacov Drory, Shlomo Kravetz, Gilad Hirschberger
A decrease in sexual activity after an acute myocardial infarction (AMI) for both women and men has been reported with one study suggesting that this reduction in sexual activity may precede rather than proceed the AMI. The present study compared the sexual activity of women and men before AMI to the sexual activity of a normative community sample of women and men, to examine whether the above reduction in sexual activity is especially characteristic of women and men who later incur an AMI. This study also investigated the association between selected medical and sociodemographic variables and sexual inactivity of women and men before an AMI...
2002: Cardiology
C Fernández-Andrade
An important task of the nephrologists during the last century, it has been the search of elements and means that allow us, with the adequate precision, to correlate the functional deterioration of the kidney, and the patient's clinical reality. And the continuous searching of factors and markers that injure them, the prognosis, and early diagnosis, to be able to predict the degree of the organs and patient's survival. Almost parallel survival presage in the natural history of the illness, almost one century ago...
2002: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
V A Moisés, R L Ferreira, E Nozawa, R M Kanashiro, O Campos, J L Andrade, A C Carvalho, P J Tucci
OBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction...
August 2000: Arquivos Brasileiros de Cardiologia
A Sánchez Rodríguez, J M Jiménez Moragas, M Marín Gurrea, J Ravina Sanz, A Sánchez Heredia
We describe the case of a 35-year-old male, who presented with sudden death, secondary to anterior miocardial infarction due to embolism. Echocardiography, transthoracic and transesophageal, revealed a tumor in the anterior mitral leaflet. Tumor, histopathologically an papillary fibroelastoma, was excised and the mitral valve was replaced with a mechanical prosthetic valve. We revised the current literature on intracardiac papillary fibroelastoma.
May 2000: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
A Moreno Ortigosa, F J Ochoa Gómez, E Ramalle-Gómara, I Saralegui Reta, M V Fernández Esteban, M Quintana Díaz
BACKGROUND: The aim of this study was to evaluate the efficacy of an structured intervention based on a medical advice versus to the ordinary anti-tobacco advice in patients with miocardial infarction who are attended in an Intensive Care Unit (ICU). PATIENTS AND METHODS: 90 patients were randomly selected to receive either the specific intervention (intervention group) or the ordinary advice (control group). The medical advice was given during the ICU hospitalization and during the second, the third and the fourth week...
February 19, 2000: Medicina Clínica
L Possati, A Faenza, R Spolaore, A Lapilli, V Bonomini, A Vangelista, S Stefoni, C Cetrullo, P Nanni Costa, L Pacifico, G Gaist, C Testa
From october '76 to march '79 at the Clinica Chirurgica I of the University of Bologna 50 renal graft have been performed with living donor in 8 cases and with cadaver donor in 42. In the living donor group there was one death for rejection and sepsis. The remaining 7 patients are all alive with normal renal function. Among the 42 patients with cadaver donor 6 died: 3 early (one for gastric hemorrage, one for necrosis of the ascending colon, and one for rejection) and 3 late (two following many rejection episodes and one for miocardial infarction)...
May 31, 1980: Minerva Chirurgica
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