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Eyelid, conjunctiva, lacrimal gland

Michelle T Sun, Andrea J O'Connor, John Wood, Robert Casson, Dinesh Selva
PURPOSE: Bioengineering aims to produce functional tissue replacements to repair defects and has been widely investigated over the past few decades. We aimed to review the available literature on the application of tissue engineering in ophthalmology, with a particular focus on ophthalmic plastic surgery and potential applications for eyelid reconstruction. METHODS: A literature search was performed on the MEDLINE database using the keywords "bioengineering," "tissue engineering," and "ophthalmology...
October 5, 2016: Ophthalmic Plastic and Reconstructive Surgery
Natthanet Sritrakoon, Phudit Maneesaay, Winyu Karntip, Aree Thayananuphat
A 9-month-old female Domestic Short-haired cat was presented with a mass of three-month duration at the base of the third eyelid of the right eye (OD). Fine-needle aspiration was carried out at another clinic, revealing clear fluid. The mass soon reformed, and the cat was referred. Ophthalmic examination revealed a pale-pink, smooth, oval mass under the conjunctiva on the anterior aspect of the third eyelid. Surgical removal of the mass was performed. Histopathology revealed a large dilated cyst together with a number of small cysts lined by simple cuboidal, and low squamous epithelium with some secretory cells...
July 2016: Veterinary Ophthalmology
Jean Guffey Johnson, Lauren A Terpak, Curtis E Margo, Reza Setoodeh
BACKGROUND: Low-grade B-cell lymphomas located around the eye present unique challenges in diagnosis and treatment. Extranodal marginal zone B-cell lymphoma is the most common lymphoma of the ocular adnexa (conjunctiva, orbit, lacrimal gland, and eyelid). METHODS: A systematic search of the relevant literature was performed. Material pertinent to the diagnosis, prognosis, pathogenesis, and treatment of extranodal marginal zone B-cell lymphoma of the ocular adnexa was identified, reviewed, and analyzed, focusing on management strategies for primary localized disease...
April 2016: Cancer Control: Journal of the Moffitt Cancer Center
Max Carlos Ramírez Soto
PURPOSE: To describe the clinical and epidemiologic characteristics of sporotrichosis in ocular adnexa and give an insight into factors associated with this condition. DESIGN: Retrospective case series and literature review. METHODS: We retrospectively reviewed all cases of sporotrichosis in ocular adnexa between 2004 and 2014 in the Santa Teresa Clinic of Abancay, Peru and reviewed all case reports of sporotrichosis in ocular adnexa in the literature...
February 2016: American Journal of Ophthalmology
Melda Cömert Özkan, Melis Palamar, Murat Tombuloğlu, Mine Hekimgil, Nazan Özsan, Güray Saydam, Fahri Şahin
Ocular adnexal lymphoma (OAL) is a rare manifestation of non-Hodgkin lymphoma consisting of the tissues and structures surrounding the eye that include the conjunctiva, eyelids, lacrimal gland, and orbital soft tissues. OAL comprise 1% to 2% of all non-Hodgkin lymphomas and about 8% of the extranodal lymphomas; however, the incidence of OAL has increased by approximately 6% annually in last 2 decades, and OAL now represents the majority of orbital malignancies. There are no uniform treatment guidelines for OAL...
June 2015: Clinical Lymphoma, Myeloma & Leukemia
Rolando Enrique D Domingo, Lilibeth E Manganip, Rolando M Castro
OBJECTIVE: We aimed to identify and describe the clinicopathologic characteristics of tumors of the eye and ocular adnexa at the Philippine Eye Research Institute. METHODS: The pathology reports of specimens submitted to the Ocular Pathology Section of the Philippine Eye Research Institute over a 10-year period (2003-2012) were reviewed, and collected data was subjected to descriptive statistical tabulation and analysis. RESULTS: A total of 1,551 histologically confirmed tumors were included...
2015: Clinical Ophthalmology
Pengde Guo, Junfang Xian, Guangli Chen, Xihong Liang, Bentao Yang, Zhenchang Wang, Fei Yan
OBJECTIVE: To explore the distribution and magnetic resonance imaging or computed tomography (MRI/CT) of lymphoma in orbit. METHODS: Retrospective analyses were conducted for 73 cases with ocular complaints at Beijing Tong'ren Hospital from June 2006 to September 2012. They were confirmed pathologically as lymphoma with complete MRI/CT records. RESULTS: Ocular adnexal lymphoma occurred predominantly in adults. There were 47 males and 26 females with a median age of (60 ± 12...
March 24, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Joanna Klećkowska-Nawrot, Renata Nowaczyk, Karolina Goździewska-Harłajczuk, Karolina Barszcz, Artur Kowalczyk, Ewa Łukaszewicz
Normal structure of the accessory organs of the eye is essential for normal eye physiology. Among the most important accessory organs of the eye are the eyelids, the conjunctiva-associated lymphoid tissue (CALT) and the lacrimal gland (LG). The aim of this study was to demonstrate the histological structure of the eyelids and LG by histochemical and ultrastructural analysis. The study was performed on 13 adult female Bilgorajska geese. Eyelid samples were stained with the Alcian blue (AB pH 2.5) and periodic acid-Schiff (PAS) methods...
January 2016: Anatomical Science International
Zhengwei Zhang, Song Sun
PURPOSE: To describe a case of sebaceous carcinoma of the caruncle and review relevant literature to raise awareness about this rare disease. CASE REPORT: A 63-year-old Chinese man presented with a nontender mass that had developed within the right lacrimal caruncle more than 3 years previously and had been growing in size. The patient was admitted to the hospital, and no systemic diseases were noted on physical and instrumental examinations. The mass was removed intact, and 10 small map biopsies of the surrounding conjunctiva and deeper tissues were performed...
March 2014: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Cynthia I Tung, Andrew F Perin, Koray Gumus, Stephen C Pflugfelder
PURPOSE: To evaluate relationships between tear meniscus dimensions and parameters of ocular surface disease in a variety of tear dysfunction conditions. DESIGN: Single-institution prospective observational study. METHODS: This study from the Baylor College of Medicine included 128 eyes of 64 subjects. Cross-sectional lower tear meniscus height and tear meniscus area were measured using optical coherence tomography and were compared with tear break-up time (TBUT), corneal staining, conjunctival staining, and an irritation symptom questionnaire (Ocular Surface Disease Index)...
February 2014: American Journal of Ophthalmology
Hind M Alkatan, Ahmad Alaraj, Albarah El-Khani, Osama Al-Sheikh
PURPOSE: To study the pattern of ocular adnexal lymphoproliferative disorders (OALD) in an ophthalmic referral center in Saudi Arabia and to review their, histopathological characteristics with clinical correlation. METHODS: Retrospective chart review of 40 cases of patients who underwent incisional biopsy with the suspected diagnosis of periocular and/or adnexal lymphoid lesions over the period: 2000-2012 at the King Khaled Eye Specialist Hospital (KKESH), Riyadh, Saudi Arabia...
July 2013: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Amr Nassar, Khalid F Tabbara, Mahmoud Aljurf
Allogeneic hematopoietic stem cell transplantation (HSCT) has evolved over the past two decades to become the standard of care for hematologic and lymphoid malignancies. Major ocular complications after allogeneic HSCT have been increasing in number and severity. Graft-versus-host disease (GVHD) remains a major cause of ocular morbidity after allogeneic HSCT. The main objective of this review is to elucidate the ocular complications in patients developing GVHD following HSCT. Ocular complications secondary to GVHD are common and include dry eye syndrome, acquisition of ocular allergy from donors with allergic disorders...
July 2013: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Peter Kristian Rasmussen
UNLABELLED: Diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) constitute two distinct subtypes of non-Hodgkin lymphoma (NHL) associated with considerable morbidity and mortality. Marked diversities with regard to molecular biology and clinical features are recognized in different subsets of the two lymphomas. Because these differences could be related to the location of the lymphoma, it is of interest to investigate the clinical and histopathological features of DLBCL and MCL involving the ocular adnexal region (i...
July 2013: Acta Ophthalmologica
Arghya Bandyopadhyay, Kaushik Majumdar, Mimi Gangopadhyay, Kalyan Khan, Subrata Chakraborty, Asim Kr Ghosh
Ocular adnexal lymphomas (OAL) involve the peri-global soft tissues like orbit, eyelid, conjunctiva, lacrimal gland. We describe a rare case of primary bilateral OAL, histomorphologically small lymphocytic lymphoma, B cell phenotype of lacrimal gland origin. Rapid intraoperative diagnosis can be suggested on imprint cytology; subsequent histology and immunohistochemistry are helpful for confirmation and further line of management. Since no preformed lymphoid structures are expected within the orbit or lacrimal gland, any lymphoid mass here should be critically evaluated as a lymphoproliferative lesion...
January 2013: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Christoffer Hother, Peter Kristian Rasmussen, Tejal Joshi, Ditte Reker, Ulrik Ralfkiær, Christopher T Workman, Steffen Heegaard, Elisabeth Ralfkiær, Kirsten Grønbæk
PURPOSE: Ocular adnexal lymphoma (i.e., lymphoma with involvement of the orbit, eyelids, conjunctiva, lacrimal gland, and lacrimal sac), although rare, is common among malignant tumors involving the ocular adnexal region. The main subtypes are low-grade extranodal marginal zone lymphoma (EMZL) and aggressive diffuse large B-cell lymphoma (DLBCL). In rare cases, low-grade EMZL are reported to transform to DLBCL. It is unclear, however, which genetic events distinguish low-grade disease from aggressive, potentially fatal disease...
August 2013: Investigative Ophthalmology & Visual Science
Tannin A Schmidt, David A Sullivan, Erich Knop, Stephen M Richards, Nadja Knop, Shaohui Liu, Afsun Sahin, Raheleh Rahimi Darabad, Sheila Morrison, Wendy R Kam, Benjamin D Sullivan
IMPORTANCE: Lubricin may be an important barrier to the development of corneal and conjunctival epitheliopathies that may occur in dry eye disease and contact lens wear. OBJECTIVE: To test the hypotheses that lubricin (ie, proteoglycan 4 [PRG4 ]), a boundary lubricant, is produced by ocular surface epithelia and acts to protect the cornea and conjunctiva against significant shear forces generated during an eyelid blink and that lubricin deficiency increases shear stress on the ocular surface and promotes corneal damage...
June 2013: JAMA Ophthalmology
B Qiu, Y B Lin, Q Q Cai, Y M Hu, D F Wang, Z D Lin, Y Liang
BACKGROUND AND METHODS: Lymphoepithelioma-like carcinoma (lelc) is a rare malignancy in ocular adnexa. Here, we report 4 patients with lelc and review 11 patients reported in the literature. Clinical profiles, association with Epstein-Barr virus (ebv), treatment, and outcomes are analyzed. RESULTS: Lacrimal glands and the lacrimal drainage system, eyelid, and conjunctiva are potential primary sites for lelc. The tumours are characterized histologically by nests of undifferentiated malignant cells surrounded by lymphoid infiltrates...
April 2013: Current Oncology
Edgar M Espana, Sejal Shah, Marcony R Santhiago, Arun D Singh
Graft versus H\host disease (GVHD) can be a devastating complication following bone marrow transplantation. Acute or chronic systemic GVHD can be lethal, and severe damage of different organs and tissues can occur with both types of GVHD. Ocular involvement, either in an acute or chronic presentation, may range from mild to severe with accompanying vision loss present in 60-90 % of patients. Chronic ocular GVHD, the most common form of GVHD, affects mainly the lacrimal gland, meibomian glands, cornea and conjunctiva, mimicking other immunologically mediated inflammatory diseases of the ocular surface without specific symptoms or signs...
May 2013: Graefe's Archive for Clinical and Experimental Ophthalmology
Yasuhiro Takahashi, Akihide Watanabe, Hiromichi Matsuda, Yasuhisa Nakamura, Takashi Nakano, Ken Asamoto, Hiroshi Ikeda, Hirohiko Kakizaki
The eyelid and conjunctiva are main targets in ophthalmic plastic surgery. Although dry eyes are known to occasionally occur after ophthalmic plastic surgery, little attention has been paid to the secretory glands in the eyelid and conjunctiva. The secretary glands in the eyelid and conjunctiva contain the main lacrimal gland, accessory lacrimal glands of Wolfring and Krause, goblet cells, ciliary glands of Moll and Zeis, and the meibomian gland of the tarsal plate. Understanding the details of these glands is helpful in preventing and managing secretion reduction after oculoplastic procedures...
May 2013: Ophthalmic Plastic and Reconstructive Surgery
Winston W-Y Kao, Hongshan Liu, Jianhua Zhang
During embryonic development, surface ectoderm differentiates to form corneal, conjunctival, and eyelid epidermal epithelia, and glandular epithelium (lacrimal and meibomian glands). Periocular mesenchymal cells of neural crest origin migrate and differentiate, leading to the formation of corneal endothelium and the stromas of the cornea, conjunctiva, eyelids, and trabecular meshwork. The formation of functional ocular surface tissues requires coordinated spatial and temporal expression of transcription factors and signaling molecules of various cytokines and signaling pathways, and the synthesis and remodeling of unique extracellular matrix...
January 2013: Ocular Surface
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