keyword
MENU ▼
Read by QxMD icon Read
search

adult onset still's disease

keyword
https://www.readbyqxmd.com/read/29784018/adding-colchicine-to-immunosuppressive-treatments-a-potential-option-for-biologics-refractory-adult-onset-still-s-disease
#1
Tomoyuki Asano, Makiko Yashiro Furuya, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Kiyoshi Migita
BACKGROUND: Adult-onset Still's disease (AOSD) is a rare inflammatory disorder characterized by the classical triad of daily spiking fever, arthritis, and typical salmon-colored rash. Resistance to first-line corticosteroids and second-line disease modified anti-rheumatic-drugs defines refractory AOSD, which mostly includes the polycyclic or chronic courses of the disease. Anti-cytokine therapies are recommended in AOSD patients who are refractory to traditional treatments. This is the first report on the efficacy of colchicine in a patient with AOSD which was refractory to immunosuppressive treatments including biologics...
May 21, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29782428/unprovoked-pulmonary-embolism-identified-on-initial-presentation-of-adult-onset-still-disease-in-an-elderly-patient-with-no-malignancy
#2
Manjeet Bhamra, Abhimanyu Amarnani, David Ozeri
No abstract text is available yet for this article.
May 19, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29782055/clinical-and-immunological-effects-of-adsorptive-myeloid-lineage-leukocyte-apheresis-in-patients-with-immune-disorders
#3
REVIEW
Takuro Kanekura
Adsorptive granulocyte and monocyte apheresis (GMA) with the Adacolumn® is an extracorporeal treatment, which uses cellulose acetate (CA) beads as adsorptive leukocytapheresis carriers designed to remove elevated and potentially activated myeloid lineage leukocytes. Reports on the clinical efficacy of GMA in patients with skin lesions have appeared in the published work. Dermatological diseases, which are known to respond to GMA, include pyoderma gangrenosum, skin lesions of Behçet's disease, rheumatoid arthritis, pustular psoriasis, psoriatic arthritis, adult-onset Still's disease, Sweet's syndrome, cutaneous allergic vasculitis and systemic lupus erythematosus rashes...
May 21, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29742054/overview-of-fever-of-unknown-origin-in-adult-and-paediatric-patients
#4
REVIEW
Luciano Attard, Marina Tadolini, Domenico Umberto De Rose, Marco Cattalini
Fever of unknown origin (FUO) can be caused by a wide group of diseases, and can include both benign and serious conditions. Since the first definition of FUO in the early 1960's, several updates to the definition, diagnostic and therapeutic approaches have been proposed. This review outlines a case report of an elderly Italian male patient with high fever and migrating arthralgia who underwent many procedures and treatments before a final diagnosis of Adult-onset Still's disease was achieved. This case report highlights the difficulties in diagnosing certain causes of FUO that requires a very high index of suspicion...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29733534/adult-onset-still-s-disease-initially-thought-to-be-an-odontogenic-infection-a-case-report
#5
Shunsuke Hino, Satoshi Nakamura, Takahiro Kaneko, Norio Horie, Tetsuo Shimoyama
OBJECTIVE: To present a case of Adult-onset Still's disease (AOSD) initially suspected to be odontogenic inflammation. BACKGROUND: Adult-onset Still's disease is a rare, complex autoinflammatory disease and a known cause of fever of unknown origin. MATERIALS AND METHODS: The patient had both a fever and dental pain. Following meticulous examination, the patient was diagnosed with AOSD. CONCLUSION: Clinicians should keep in mind that a patient such as AOSD may visit their clinics...
June 2018: Gerodontology
https://www.readbyqxmd.com/read/29731191/-intra-cardiac-manifestation-during-adult-onset-still-s-disease-s-a-tricuspid-vegetation-as-a-rare-expression-of-systemic-disease
#6
Q Quelven, B Cador, M Poinot, E Fletcher, E Le Mouel, P Jego
INTRODUCTION: Adult-onset Still's Disease is a rare multisystemic inflammatory disease characterized by fever, maculo-papular erythematous rash and arthralgia. Adult-onset Still's disease is a diagnosis of exclusion. CASE REPORT: We report the case of a 33 years old man, hospitalized for fever, arthralgia and throat manifestations, leading to Adult-onset Stills's Disease diagnosis. Cardiac ultrasound revealed tricuspid vegetation. Once infectious causes were ruled out, the vegetation was related to Adult-onset Still's Disease according to Fautrel and Yamaguchi criteria...
May 3, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29729254/physical-exercise-reserved-amyloid-beta-induced-brain-dysfunctions-by-regulating-hippocampal-neurogenesis-and-inflammatory-response-via-mapk-signaling
#7
Li-Na Sun, Jin-Shun Qi, Rong Gao
Alzheimer's disease (AD) is one of the leading causes of dementia that induced by aggregation of amyloid-beta (Aβ) in brain tissue. With high structural and functional plasticity, hippocampus plays fundamental roles in cognitive regulation. Moreover, impaired hippocampal functions present during early onset of AD. Hence, targeting on improving hippocampal plasticity would be recognized as the effective strategy in AD therapy. Physical exercise is widely encouraged healthy life style. However, whether exercise could reserve the neural dysfunctions in AD model and the possible neurobiological mechanism still need for better understanding...
May 2, 2018: Brain Research
https://www.readbyqxmd.com/read/29723378/oral-mucosa-lesions-as-atypical-manifestation-of-adult-onset-still%C3%A2-s-disease
#8
María Lorena Brance, Eldo Luis Neffen
Adult-onset Still's disease is a systemic inflammatory disorder of unknown etiology, characterized by skin rash, spiking fever, arthralgias or arthritis, and leukocytosis. The typical skin rash is evanescent, salmon-pink, nonpruritic and maculopapular, predominantly on the extremities. It is considered one of the major Yamaguchi's criteria in adult-onset Still's disease. However, atypical skin lesions are also described. Here, a 61-year-old woman with sore throat, spiking fever, polyarthritis and evanescent salmon-pink nonpruritic maculopapular skin rash on the extremities was diagnosed with adult-onset Still's disease...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29722877/rituximab-for-induction-and-maintenance-therapy-of-granulomatosis-with-polyangiitis-a-single-centre-cohort-study-on-114-patients
#9
Xavier Puéchal, Michele Iudici, Ana Luisa Calich, Alexandre Vivot, Benjamin Terrier, Alexis Régent, Pascal Cohen, Claire Le Jeunne, Luc Mouthon, Philippe Ravaud, Loïc Guillevin
Objectives: To assess efficacy and safety of rituximab (RTX) induction and maintenance therapy for granulomatosis with polyangiitis (GPA) in a single-centre cohort study. Methods: All patients with active GPA, not enrolled in trials, who received ⩾1 RTX infusion(s) for induction were included. At remission, protocolized maintenance RTX infusions were given every 6 months for 18 months. Kaplan-Meier curves were used to estimate survival rates. Univariable analyses identified factors associated with remission failure and relapse, and Cox models retained independent predictors of relapse...
May 2, 2018: Rheumatology
https://www.readbyqxmd.com/read/29660063/five-successful-pregnancies-with-antenatal-anakinra-exposure
#10
Chelsey J F Smith, Christina D Chambers
Objectives: Our aim is to add to the limited existing prospective data on IL-1 inhibitor use in pregnancy. Methods: Data were obtained from the Organization of Teratology Information Specialists Autoimmune Disease in Pregnancy Project, a prospective cohort study of pregnancy outcomes in the USA and Canada. Eligible women were enrolled prior to 19 weeks' gestation between 2004 and 2017. Outcomes were obtained by maternal interview and medical record abstraction. Results: Five pregnancies with anakinra exposure were identified, all resulting in full-term singleton live births with no major or long-term complications...
April 12, 2018: Rheumatology
https://www.readbyqxmd.com/read/29658384/complications-of-adult-onset-still-s-disease-and-their-management
#11
Stéphane Mitrovic, Bruno Fautrel
Adult-onset Still's disease (AOSD) is a rare systemic auto-inflammatory disorder in which management and treatment have considerably progressed over the past decade. Despite wide use of interleukin (IL)-1 or IL-6 inhibitors, serious complications remain possible. Areas covered: A comprehensive literature search in MEDLINE via Pubmed was performed to review AOSD's severe and sometimes life-threatening complications: reactive hemophagocytic lymphohystiocytosis, coagulation disorders, fulminant hepatitis, cardiac or pulmonary complications and amyloid A amyloidosis...
April 26, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29657144/macrophage-activation-syndrome-in-patients-affected-by-adult-onset-still-disease-analysis-of-survival-rates-and-predictive-factors-in-the-gruppo-italiano-di-ricerca-in-reumatologia-clinica-e-sperimentale-cohort
#12
Piero Ruscitti, Daniela Iacono, Francesco Ciccia, Giacomo Emmi, Paola Cipriani, Rosa Daniela Grembiale, Federico Perosa, Lorenzo Emmi, Giovanni Triolo, Roberto Giacomelli, Gabriele Valentini
OBJECTIVE: Macrophage activation syndrome (MAS) is a reactive form of hemophagocytic lymphohistiocytosis, which can complicate adult-onset Still disease (AOSD). We investigated AOSD clinical features at the time of diagnosis, to assess predictors of MAS occurrence. Further, we analyzed the outcomes of patients with AOSD who experience MAS. METHODS: Patients with AOSD admitted to any Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale center were retrospectively analyzed for features typical of AOSD, MAS occurrence, and their survival rate...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29656361/characterization-of-the-mitochondrial-aerobic-metabolism-in-the-pre-and-perisynaptic-districts-of-the-sod1-g93a-mouse-model-of-amyotrophic-lateral-sclerosis
#13
Silvia Ravera, Tiziana Bonifacino, Martina Bartolucci, Marco Milanese, Elena Gallia, Francesca Provenzano, Katia Cortese, Isabella Panfoli, Giambattista Bonanno
Amyotrophic lateral sclerosis (ALS) is an adult-onset fatal neurodegenerative disease characterized by muscle wasting, weakness, and spasticity due to a progressive degeneration of cortical, brainstem, and spinal motor neurons. The etiopathological causes are still largely obscure, although astrocytes definitely play a role in neuronal damage. Several mechanisms have been proposed to concur to neurodegeneration in ALS, including mitochondrial dysfunction. We have previously shown profound modifications of glutamate release and presynaptic plasticity in the spinal cord of the SOD1 G93A mouse model of ALS...
April 14, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29651907/evidence-based-clinical-practice-guideline-for-adult-still-s-disease
#14
Toshihide Mimura, Yuya Kondo, Akihide Ohta, Masahiro Iwamoto, Akiko Ota, Nami Okamoto, Yasushi Kawaguchi, Hajime Kono, Yoshinari Takasaki, Shuji Takei, Norihiro Nishimoto, Manabu Fujimoto, Yu Funakubo Asanuma, Akio Mimori, Naoko Okiyama, Shunta Kaneko, Hiroyuki Takahashi, Masahiro Yokosawa, Takayuki Sumida
OBJECTIVES: Using an expert- and data-driven methodology, we have constructed the first clinical practice guidelines (CPGs) for adult Still's disease (ASD) after complete systematic review (SR) of the literature based upon the Medical Information Network Distribution Service (Minds) procedure. METHODS: The CPG committee for ASD organized by the Research Team for Autoimmune Diseases, the Research Program for Intractable Disease of the Japanese Ministry of Health, Labour, and Welfare has developed CPG for ASD 2017, according to the procedure proposed by Minds...
May 9, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29642928/diagnostic-and-management-of-life-threatening-adult-onset-still-disease-a-french-nationwide-multicenter-study-and-systematic-literature-review
#15
Antoine Néel, Anaïs Wahbi, Benoit Tessoulin, Julien Boileau, Dorothée Carpentier, Olivier Decaux, Laurence Fardet, Guillaume Geri, Pascal Godmer, Cécile Goujard, Hervé Maisonneuve, Arnaud Mari, Jacques Pouchot, Jean-Marc Ziza, Cédric Bretonnière, Mohamed Hamidou
BACKGROUND: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder. A few patients develop organ complications that can be life-threatening. Our objectives were to describe the disease course and phenotype of life-threatening AOSD, including response to therapy and long-term outcome. METHODS: A multicenter case series of intensive care medicine (ICU) patients with life-threatening AOSD and a systematic literature review. RESULTS: Twenty patients were included...
April 11, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29625671/selective-igm-deficiency-associated-with-adult-onset-still-disease
#16
Jessica Oh, David McGarry, Brian Peppers, Robert Hostoffer
No abstract text is available yet for this article.
April 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29600942/serum-epstein-barr-virus-dna-detected-by-droplet-digital-pcr-correlates-with-disease-activity-in-patients-with-rheumatoid-arthritis
#17
Elina Kuusela, Vesa-Petteri Kouri, Juri Olkkonen, Riitta Koivuniemi, Leena Äyräväinen, Kristiina Rajamäki, Heikki Valleala, Dan Nordström, Marjatta Leirisalo-Repo, Mari Ainola, Kari K Eklund
OBJECTIVES: To study the prevalence of asymptomatic activation of Epstein-Barr virus (EBV) in patients with rheumatoid arthritis (RA) and to analyse the correlation of serum EBV DNA with the disease activity. METHODS: The level of EBV DNA was determined by droplet digital PCR assay from the serum of 46 DMARD naive early RA (ERA) and 22 chronic RA (CRA)-patients at study onset. Follow-up samples from 31 ERA and 16 CRA patients were obtained after starting or modifying the anti-rheumatic treatment...
March 20, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29567074/effect-of-diabetes-duration-and-glycaemic-control-on-14-year-cause-specific-mortality-in-mexican-adults-a-blood-based-prospective-cohort-study
#18
William G Herrington, Jesus Alegre-Díaz, Rachel Wade, Louisa Gnatiuc, Raúl Ramirez-Reyes, Michael Hill, Martha Solano-Sánchez, Colin Baigent, Sarah Lewington, Rory Collins, Roberto Tapia-Conyer, Richard Peto, Pablo Kuri-Morales, Jonathan R Emberson
BACKGROUND: Diabetes is a cause of at least a third of all deaths in Mexican adults aged 35-74 years, with the excess mortality due mainly to vascular disease, renal disease, infection, and acute diabetic crises. We aimed to analyse the effect of diabetes duration and glycaemic control on death rate ratios (RRs) for these causes and to assess the relevance to cause-specific mortality of undiagnosed diabetes. METHODS: About 100 000 women and 50 000 men aged 35 years or older from Mexico City were recruited into a blood-based prospective study between April 14, 1998, and Sept 28, 2004, and followed up until Jan 1, 2016, for cause-specific mortality...
March 19, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29566725/interleukin-37-is-increased-in-adult-onset-still-s-disease-and-associated-with-disease-activity
#19
Huihui Chi, Dongzhou Liu, Yue Sun, Qiongyi Hu, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Yufeng Yin, Mengru Liu, Xinyao Wu, Zhuochao Zhou, Jialin Teng, Chengde Yang, Yutong Su
BACKGROUND: Interleukin (IL)-37 has been known to play an immunosuppressive role in various inflammatory disorders, but whether it participates in the regulation of pathogenesis of adult-onset Still's disease (AOSD) has not been investigated. In this study, we examined serum IL-37 levels and their clinical association with AOSD, and we explored the anti-inflammatory effects of IL-37 on peripheral blood mononuclear cells (PBMCs) from patients with AOSD. METHODS: Blood samples were collected from 62 patients with AOSD and 50 healthy control subjects (HC)...
March 22, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29565301/efficacy-of-denosumab-for-osteoporosis-in-two-patients-with-adult-onset-still-s-disease-denosumab-efficacy-in-osteoporotic-still-s-disease-patients
#20
Daiki Kumaki, Yukio Nakamura, Takako Suzuki, Hiroyuki Kato
Adult-onset Still's disease (AOSD) is an autoimmune inflammatory disorder. Glucocorticoids are often used for AOSD, which may induce complicating glucocorticoid-induced osteoporosis (GIO). An anti-resorption drug, denosumab, has recently been approved for osteoporosis treatment in Japan. However, the drug's efficacy for GIO in AOSD is largely unknown. This retrospective, consecutive case series investigated two patients with GIO in AOSD to examine the effects of denosumab on bone metabolism. Bone turnover markers, and bone mineral density (BMD) of the lumbar 1-4 spine (L-BMD) and bilateral total hips (H-BMD) were followed for six months in a male patient and for twelve months in a female patient...
March 22, 2018: Journal of Clinical Medicine
keyword
keyword
28813
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"