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coronary flow reserve

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https://www.readbyqxmd.com/read/29779179/clinical-outcomes-of-complete-revascularization-using-either-angiography-guided-or-fractional-flow-reserve-guided-drug-eluting-stent-implantation-in-non-culprit-vessels-in-st-elevation-myocardial-infarction-patients-insights-from-a-study-based-on-a-systematic
#1
REVIEW
Alexandre Hideo-Kajita, Hector M Garcia-Garcia, Kayode O Kuku, Solomon S Beyene, Viana Azizi, Yael F Meirovich, Gebremedhin D Melaku, Aaphtaab Dheendsa, Echo J Brathwaite, Sameer Desale, Mohammad Soud, Kazuhiro Dan, Yuichi Ozaki, Ron Waksman, Michael Lipinski
Current guidelines recommend that percutaneous coronary intervention (PCI) should be restricted to the culprit vessel in ST elevation myocardial infarction (STEMI) patients with multi-vessel disease (MVD) and without cardiogenic shock. However, newer data suggests that performing complete revascularization (CR) in MVD patients may lead to better outcomes compared to intervention in the culprit vessel only. The aim of this meta-analysis is to examine the available data to determine if CR (using either angio- or fractional flow reserve guidance-FFR) following primary PCI in STEMI patients without cardiogenic shock impacts clinical outcomes...
May 19, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29779046/sex-differences-in-the-long-term-prognostic-value-of-13-n-ammonia-myocardial-perfusion-positron-emission-tomography
#2
Catherine Gebhard, Michael Fiechter, Bernhard A Herzog, Christine Lohmann, Susan Bengs, Valerie Treyer, Michael Messerli, Dominik C Benz, Andreas A Giannopoulos, Christoph Gräni, Aju P Pazhenkottil, Ronny R Buechel, Philipp A Kaufmann
PURPOSE: Evidence to date on the unique female determinants of cardiovascular risk is inadequate. Positron Emission Tomography (PET) is considered to have the highest accuracy for the assessment of myocardial perfusion in patients with suspected coronary artery disease (CAD), but its long-term prognostic accuracy in women has not been established. METHODS: A total of 619 consecutive patients (138 women, mean age 60.0 ± 11.8 years) underwent clinically indicated 13 N-ammonia PET at our institution and were followed up (median 5...
May 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29778317/appropriate-use-of-noninvasive-ischemia-testing-to-guide-revascularization-decision-making-following-acute-st-elevation-myocardial-infarction-in-latin-american-countries-results-from-an-expert-panel-meeting-of-the-international-atomic-energy-agency
#3
I Berrocal, A Peix, F Mut, L J Shaw, G Karthikeyan, E Estrada Lobato, D Paez
Across Latin American and Caribbean countries, cardiovascular disease and especially ischemic heart disease is currently the main cause of death both in men and in women. For most Latin American and Caribbean countries, public and community health efforts aim to define care strategies which are both clinically and cost effective and promote primary and secondary prevention, resulting in improved patient outcomes. The optimal approach to deal with acute events such as ST-elevation myocardial infarction (STEMI) is a matter of controversy; however, there is an expanding role for assessing residual ischemic burden in STEMI patients following primary percutaneous coronary intervention...
May 16, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29774406/reduced-global-myocardial-perfusion-reserve-in-dcm-and-hcm-patients-assessed-by-cmr-based-velocity-encoded-coronary-sinus-flow-measurements-and-first-pass-perfusion-imaging
#4
Michael Bietenbeck, Anca Florian, Zornitsa Shomanova, Claudia Meier, Ali Yilmaz
BACKGROUND: Coronary microvascular dysfunction (CMD) is an independent predictor of poor prognosis in patients suffering from dilative or hypertrophic cardiomyopathy (DCM/HCM). To assess CMD, quantitative myocardial first-pass perfusion (1P) cardiovascular magnetic resonance (CMR) can be performed. Coronary sinus flow (CSF) measurements at rest and during maximal vasodilatation are an alternative and well-validated approach for the quantification of global myocardial blood flow (MBF) in CMR...
May 17, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29772738/angiogenesis-pet-tracer-uptake-68-ga-nodaga-e-crgdyk-%C3%A2-in-induced-myocardial-infarction-and-stromal-cell-treatment-in-minipigs
#5
Thomas Rasmussen, Bjarke Follin, Jens Kastrup, Malene Brandt-Larsen, Jacob Madsen, Thomas Emil Christensen, Morten Juhl, Smadar Cohen, Karsten Pharao Hammelev, Christian Holdflod Møller, Jens Peter Goetze, Philip Hasbak, Andreas Kjær
Angiogenesis is considered integral to the reparative process after ischemic injury. The αv β₃ integrin is a critical modulator of angiogenesis and highly expressed in activated endothelial cells. 68 Ga-NODAGA-E[(cRGDyK)]₂ (RGD) is a positron-emission-tomography (PET) ligand targeted towards αv β₃ integrin. The aim was to present data for the uptake of RGD and correlate it with histology and to further illustrate the differences in angiogenesis due to porcine adipose-derived mesenchymal stromal cell (pASC) or saline treatment in minipigs after induction of myocardial infarction (MI)...
May 16, 2018: Diagnostics
https://www.readbyqxmd.com/read/29769168/pressure-wire-compared-to-microcatheter-sensing-for-coronary-fractional-flow-reserve-the-perform-study
#6
Ziad A Ali, Yasir Parviz, Matthew Brinkman, Mitsuaki Matsumura, Björn Redfors, David A Brogno, Maria D Corral, Khady N Fall, Gary S Mintz, Gregg W Stone, Akiko Maehara, Allen Jeremias, Ajay J Kirtane
AIMS: Among technologies used to assess FFR, a monorail, sensor-tipped micro pressure catheter (PC) may be advantageous for delivery and re-assessment. We sought to determine whether the larger cross-sectional area of the PC influences FFR measurements compared to the pressure wire. METHODS AND RESULTS: PERFORM was a single-center, prospective study designed to determine the precision and accuracy of the PC compared with the pressure wire (PW) for measurement of FFR...
May 15, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29769166/coronary-lesion-progression-as-assessed-by-fractional-flow-reserve-ffr-and-angiography
#7
Panagiotis Xaplanteris, Argyris Ntalianis, Bernard De Bruyne, Teresa Strisciuglio, Mariano Pellicano, Giovanni Ciccarelli, Anastasios Milkas, Emanuele Barbato
AIMS: To explore the evolution of coronary lesions that had repeated physiologic evaluation by FFR as an endpoint, describe the clinical significance of longitudinal FFR change (ΔFFR = FFR follow-up - FFR baseline), its correlation with angiographic indices and identify predictors of FFR follow-up. METHODS AND RESULTS: A retrospective, single-center analysis of 414 stenoses (331 patients) with consecutive FFR measurements at least six months apart was performed [median time interval: 24 (17, 37) months]...
May 15, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29761608/effect-of-renal-denervation-on-coronary-flow-reserve-in-patients-with-resistant-hypertension
#8
Sebastian Völz, Bert Andersson, Charlotta Ljungman, Li-Ming Gan, Bengt Rundqvist, Sara Svedlund
Renal denervation (RDN) is a potential modality in the treatment of patients with resistant hypertension (RH) and has shown beneficial effect on a variety of cardiovascular surrogate markers. Coronary flow reserve, as assessed by transthoracic Doppler echocardiography (TDE-CFR) is impaired in patients with hypertension and is an independent predictor of cardiac morbidity. However, data on the effect of RDN on TDE-CFR are scarce. The main objective of this study was to assess the effect of RDN on TDE-CFR. Twenty-six consecutive patients with RH (9 female and 17 male; mean age 62 ± 8 years; mean number of antihypertensive drugs 4·2 ± 1·6) underwent bilateral RDN...
May 14, 2018: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29760346/effect-of-sitagliptin-on-coronary-flow-reserve-assessed-by-magnetic-resonance-imaging-in-type-2-diabetic-patients-with-coronary-artery-disease
#9
Keishi Moriwaki, Tetsushiro Takeuchi, Naoki Fujimoto, Toshiki Sawai, Yuichi Sato, Naoto Kumagai, Jun Masuda, Shiro Nakamori, Masaki Ishida, Norikazu Yamada, Mashio Nakamura, Hajime Sakuma, Masaaki Ito, Kaoru Dohi
BACKGROUND: The present study was conducted to assess the cardiovascular effects of dipeptidyl peptidase-4 inhibitors (DPP4i) on coronary flow reserve (CFR), left ventricular (LV) function and endothelial function of the peripheral artery by comparison with those of α-glucosidase inhibitors (αGI) in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD).Methods and Results:We randomly assigned 30 patients with T2DM and CAD to receive either sitagliptin or voglibose, and 28 patients (age 69±9 years, 75% male, hemoglobin A1c [HbA1c] 6...
May 12, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29754669/comparison-of-fractional-flow-reserve-and-intravascular-ultrasound-guided-intervention-strategy-for-clinical-outcomes-in-patients-with-intermediate-stenosis-flavour-rationale-and-design-of-a-randomized-clinical-trial
#10
Jeehoon Kang, Bon-Kwon Koo, Xinyang Hu, Joo Myung Lee, Joo-Yong Hahn, Hyoung-Mo Yang, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Bong-Ki Lee, Chul Ahn, JianAn Wang, Seung-Jae Tahk
BACKGROUND: Coronary angiography has limitations in defining the ischemia-causing stenotic lesion, especially in cases with intermediate coronary stenosis. Fractional flow reserve (FFR) is a current standard method to define the presence of ischemia, and intravascular ultrasound (IVUS) is the most commonly used invasive imaging tool that can provide the lesion geometry and can provide the information on plaque vulnerability. The primary aim of this study is to compare the safety and efficacy of FFR-guided and IVUS-guided percutaneous coronary intervention (PCI) strategies in patients with intermediate coronary stenosis...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29754402/impact-of-mean-arterial-pressure-on-sublingual-microcirculation-during-cardiopulmonary-bypass-secondary-outcome-from-a-randomised-clinical-trial
#11
Frederik Holmgaard, Anne G Vedel, Hanne Berg Ravn, Jens C Nilsson, Lars S Rasmussen
OBJECTIVE: In this substudy of a randomised, clinical trial, we explored the sublingual microcirculation during cardiac surgery at two different levels of blood pressure. We hypothesised that a higher mean arterial pressure during cardiopulmonary bypass would cause higher Microvascular Flow Index. METHODS: Thirty-six cardiac surgery patients undergoing coronary artery bypass grafting were included and randomised to either low (40-50 mmHg) or high (70-80 mmHg) mean arterial pressure during cardiopulmonary bypass...
May 13, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29748874/correction-to-acc-aats-aha-ase-asnc-scai-scct-sts-2017-appropriate-use-criteria-for-coronary-revascularization-in-patients-with-stable-ischemic-heart-disease
#12
Manesh R Patel, John H Calhoon, Gregory J Dehmer, James Aaron Grantham, Thomas M Maddox, David J Maron, Peter K Smith
To more clearly reflect the relationship between iFR (instantaneous wave-free ratio) and FFR (fractional flow reserve), this Correction document highlights the following changes to the original document published in the Journal of Nuclear Cardiology; the version available at JACC [1] has been updated to reflect the changes, with JACC's Correction document available at [2].
May 10, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29747847/quantitative-myocardial-perfusion-imaging-versus-visual-analysis-in-diagnosing-myocardial-ischemia-a-ce-marc-substudy
#13
John D Biglands, Montasir Ibraheem, Derek R Magee, Aleksandra Radjenovic, Sven Plein, John P Greenwood
OBJECTIVES: This study sought to compare the diagnostic accuracy of visual and quantitative analyses of myocardial perfusion cardiovascular magnetic resonance against a reference standard of quantitative coronary angiography. BACKGROUND: Visual analysis of perfusion cardiovascular magnetic resonance studies for assessing myocardial perfusion has been shown to have high diagnostic accuracy for coronary artery disease. However, only a few small studies have assessed the diagnostic accuracy of quantitative myocardial perfusion...
May 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29735395/is-fractional-flow-reserve-useful-in-assessing-coronary-artery-fistula-a-case-based-discussion-and-review
#14
Samual Hayman, Aashish Goela, Shahar Lavi
We present two cases where fractional flow reserve (FFR) was utilised to guide management of coronary artery fistula (CAF), an approach advocated in recent case studies. CAF is a coronary anomaly that may present with a variety of syndromes though is frequently asymptomatic. When to exclude the fistula (surgically or percutaneously) is not always clear. A way to quantify if the fistula is physiologically meaningful would be advantageous. Our findings suggest FFR may only be assessing the concomitant epicardial coronary artery disease (CAD) rather than the degree of coronary steal and its routine use in this setting is not supported...
April 19, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29732653/the-regenerative-journey-of-pericytes-towards-clinical-translation
#15
REVIEW
William Cathery, Ashton Faulkner, Davide Maselli, Paolo Madeddu
Coronary artery disease (CAD) is the single leading cause of death worldwide. Advances in treatment and management have significantly improved patient outcomes. On the other hand, although mortality rates have decreased, more people are left with sequelae that require additional treatment and hospitalization. Moreover, patients with severe nonrevascularizable CAD remain with the only option of heart transplantation, which is limited by the shortage of suitable hearts. In recent years, cell-based regenerative therapy has emerged as a possible alternative treatment, with several regenerative medicinal products already in the clinical phase of development and other emerging as competitive preclinical solutions...
May 7, 2018: Stem Cells
https://www.readbyqxmd.com/read/29732488/coronary-flow-reserve-in-systemic-rheumatic-diseases-a-systematic-review-and-meta-analysis
#16
REVIEW
Gian Luca Erre, Giorgio Buscetta, Panagiotis Paliogiannis, Arduino Aleksander Mangoni, Ciriaco Carru, Giuseppe Passiu, Angelo Zinellu
Coronary flow reserve (CFR), a measure of both obstructive coronary artery disease and microvascular dysfunction, has been evaluated in systemic rheumatic diseases (RDs), but a comprehensive critical appraisal of the available evidence is lacking. The objective of this study is to conduct a systematic review and meta-analysis of studies with small sample size investigating the associations between the presence of RDs and CFR to increase statistical power and accuracy. PubMed, Web of Science, Scopus, and Google Scholar, from inception to March 2018, were searched for studies reporting on CFR in RDs in comparison to healthy subjects...
May 7, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29724722/coronary-artery-remodeling-and-fibrosis-with-continuous-flow-left-ventricular-assist-device-support
#17
Amrut V Ambardekar, Mary C M Weiser-Evans, Marcella Li, Suneet N Purohit, Muhammad Aftab, T Brett Reece, Karen S Moulton
BACKGROUND: Coronary artery fluid dynamics may be altered because of the nonphysiological flow seen in continuous-flow left ventricular assist devices (CF-LVADs). Our aim was to study the structure and composition of coronary vessels after CF-LVAD. METHODS AND RESULTS: Coronary arteries were collected from patients with heart failure (HF) at the time of transplantation, of whom 15 were supported with a CF-LVAD before transplant (HF+LVAD group) and 9 were not (HF non-LVAD group)...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29716756/coronary-microvascular-dysfunction-in-patients-with-stable-coronary-artery-disease-the-ce-marc-2-coronary-physiology-sub-study
#18
David Corcoran, Robin Young, David Adlam, Alex McConnachie, Kenneth Mangion, David Ripley, David Cairns, Julia Brown, Chiara Bucciarelli-Ducci, Andreas Baumbach, Rajesh Kharbanda, Keith G Oldroyd, Gerry P McCann, John P Greenwood, Colin Berry
BACKGROUND: In patients with angina undergoing invasive management, no obstructive coronary artery disease (NOCAD) is a common finding, and angina may persist following percutaneous coronary intervention (PCI). Coronary microvascular dysfunction may be relevant. We aimed to assess the proportion of patients presenting with suspected CAD who had coronary microvascular dysfunction. METHODS: Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease 2 (CE-MARC 2) was a prospective multicenter randomised controlled trial of functional imaging versus guideline-based management in patients with suspected CAD...
April 19, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29714043/vasomotion-as-an-oscillatory-sign-of-functional-impairment-in-the-human-internal-thoracic-artery-a-study-based-on-risk-factors-and-vessel-reactivity
#19
Diogo A Fonseca, Pedro E Antunes, Manuel J Antunes, Maria Dulce Cotrim
NEW FINDINGS: What is the central question of this study? Vasomotion has been viewed as a rhythmic oscillation of the vascular tone that is physiologically important for optimal tissue perfusion. Also, it has been primarily studied in the microcirculation. However, the precise underlying mechanisms and the physiological significance remain unknown. What is the main finding and its importance? Vasomotion is not specific of the microcirculation, as shown by our findings. In human arteries from patients undergoing cardiac surgery, an increased incidence was associated with endothelial dysfunction settings...
April 30, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29713819/evaluation-of-the-risk-factors-for-ventricular-arrhythmias-secondary-to-qt-prolongation-induced-by-papaverine-injection-during-coronary-flow-reserve-studies-using-a-4-fr-angio-catheter
#20
Yoshitaka Okabe, Kanichi Otowa, Yasuhito Mitamura, Hisayoshi Murai, Soichiro Usui, Shuichi Kaneko, Masayuki Takamura
Estimation of the fractional flow reserve (FFR) is considered to be an established method by which to assess stable coronary artery stenosis. Induction of maximal coronary hyperemia is important during the FFR procedure. Papaverine has been reported to increase the risk of ventricular arrhythmia (VA). The purpose of the present study was to discover predictors of papaverine-induced VAs developing during FFR measurement. A total of 213 clinically stable patients were included in the study. FFRs were determined after intracoronary papaverine administration (12 mg into the left and 8 mg into the right coronary arteries)...
April 30, 2018: Heart and Vessels
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