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cardiac output exercise

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https://www.readbyqxmd.com/read/28720715/ischemic-preconditioning-does-not-alter-muscle-sympathetic-responses-to-static-handgrip-and-metaboreflex-activation-in-young-healthy-men
#1
Anthony V Incognito, Connor J Doherty, Jordan B Lee, Matthew J Burns, Philip J Millar
Ischemic preconditioning (IPC) has been hypothesized to elicit ergogenic effects by reducing feedback from metabolically sensitive group III/IV muscle afferents during exercise. If so, reflex efferent neural outflow should be attenuated. We investigated the effects of IPC on muscle sympathetic nerve activity (MSNA) during static handgrip (SHG) and used post-exercise circulatory occlusion (PECO) to isolate for the muscle metaboreflex. Thirty-seven healthy men (age: 24 ± 5 years [mean ± SD]) were randomized to receive sham (n = 16) or IPC (n = 21) interventions...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28712261/application-of-living-high-training-low-enhances-cardiac-function-and-skeletal-muscle-oxygenation-during-submaximal-exercises-in-athletes
#2
Hun-Young Park, Sang-Seok Nam
PURPOSE: The aim of this study was to determine the efficiency of the application of living high-training low (LHTL) on cardiac function and skeletal muscle oxygenation during submaximal exercises compared with that of living low-training low (LLTL) in athletes. METHODS: Male middle- and long-distance runners (n = 20) were randomly assigned into the LLTL group (n = 10, living at 1000-m altitude and training at 700-1330-m altitude) and the LHTL group (n = 10, living at simulated 3000-m altitude and training at 700-1330-m altitude)...
March 31, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28689985/oxygen-consumption-and-carbon-dioxide-recovery-kinetics-in-the-prediction-of-coronary-artery-disease-severity-and-outcome
#3
Dejana Popovic, Dejana Martic, Tea Djordjevic, Vesna Pesic, Marco Guazzi, Jonathan Myers, Reza Mohebi, Ross Arena
BACKGROUND: Revascularization appears to be beneficial only in patients with high levels of ischemia. This study examined the utility of gas analysis during the recovery phase of cardiopulmonary exercise testing (CPET) in predicting coronary artery disease (CAD) severity and prognosis. METHODS: 40 Caucasian patients (21.2% females), mean age 63.5±7.6 with significant coronary artery lesions (≥50%) were studied. Within two months of coronary angiography, CPET on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits 2-4days apart; subjects were subsequently followed 32±10months...
June 28, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28685426/effects-of-8-weeks-training-on-systemic-and-muscle-oxygen-dynamics-in-university-rugby-players
#4
Shun Takagi, Ryotaro Kime, Masatsugu Niwayama, Kuniaki Hirayama, Shizuo Sakamoto
The aim of this study was to investigate the effects of 8 weeks of training on O2 dynamics in university rugby players. University rugby players (n = 15) participated in 5 strength training sessions and 4 field-based training sessions per week for 8 weeks. Before and after 8-weeks' training, the subjects performed ramp cycling exercise until exhaustion. Muscle O2 saturation (SmO2), relative changes from rest in deoxygenated hemoglobin concentration (∆Deoxy-Hb) and total hemoglobin concentration, cardiac output (CO), and pulmonary O2 uptake (VO2) were monitored continuously during exercise...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28683960/arterial-stiffening-with-exercise-in-patients%C3%A2-with-heart-failure-and-preserved%C3%A2-ejection-fraction
#5
Yogesh N V Reddy, Mads J Andersen, Masaru Obokata, Katlyn E Koepp, Garvan C Kane, Vojtech Melenovsky, Thomas P Olson, Barry A Borlaug
BACKGROUND: Aortic stiffening and reduced nitric oxide (NO) availability may contribute to the pathophysiology of heart failure with preserved ejection fraction (HFpEF). OBJECTIVES: This study compared indices of arterial stiffness at rest and during exercise in subjects with HFpEF and hypertensive control subjects to examine their relationships to cardiac hemodynamics and determine whether exertional arterial stiffening can be mitigated by inorganic nitrite. METHODS: A total of 22 hypertensive control subjects and 98 HFpEF subjects underwent hemodynamic exercise testing with simultaneous expired gas analysis to measure oxygen consumption...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28681553/contractile-reserve-and-cardiopulmonary-exercise-parameters-in-patients-with-dilated-cardiomyopathy-the-two-dimensions-of-exercise-testing
#6
Kegan J Moneghetti, Yukari Kobayashi, Jeffrey W Christle, Miyuki Ariyama, Bojan Vrtovec, Tatiana Kouznetsova, Andrew Wilson, Euan Ashley, Matthew T Wheeler, Johnathan Myers, Francois Haddad
BACKGROUND: Left ventricular (LV) contractile reserve assessed using imaging and cardiopulmonary exercise testing (CPX) has been shown to predict outcome in patients with dilated cardiomyopathy (DCM). Few clinical studies have, however, analyzed the relationship between them. METHODS: A cohort of 75 ambulatory patients with DCM underwent stress treadmill echocardiography with CPX. LV contractile reserve was calculated as absolute change (ΔLVEF=LVEFpeak -LVEFrest ) and percent change (%LVEF=[(LVEFpeak -LVEFrest )/LVEFpeak) ]×100) in LVEF, circumferential and longitudinal strain (LS)...
July 6, 2017: Echocardiography
https://www.readbyqxmd.com/read/28680584/use-of-thermodilution-cardiac-output-overestimates-diagnoses-of-exercise-induced-pulmonary-hypertension
#7
Steven Hsu, Samuel B Brusca, Parker S Rhodes, Todd M Kolb, Stephen C Mathai, Ryan J Tedford
Two new definitions of exercise-induced pulmonary hypertension (EIPH) have emerged. Both rely on measuring cardiac output (CO), yet this remains unstandardized. In our cohort of patients undergoing invasive cardiopulmonary exercise testing, we found that using thermodilution CO rather than direct Fick CO led to a significant excess of EIPH diagnoses.
March 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28679061/mechanisms-that-modulate-peripheral-oxygen-delivery-during-exercise-in-heart-failure
#8
Tomohiko Kisaka, William W Stringer, Akira Koike, Piergiuseppe Agostoni, Karlman Wasserman
Oxygen uptake (V̇O2) measured at the mouth, which is equal to the cardiac output (C.O.) times the arterial-venous oxygen content difference [C(a-v)O2) ], increases over 10-20 fold in normal subjects during exercise. To achieve this substantial increase in oxygen uptake (V̇O2) = C.O. x C(a-v)O2) ) both cardiac output and arterial-venous difference must simultaneously increase. While this occurs in normal subjects, patients with heart failure cannot achieve significant increases in cardiac output and must rely primarily on changes in arterial-venous difference to increase V̇O2) during exercise...
July 5, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28666992/oxygen-uptake-efficiency-slope-predicts-poor-outcome-in-patients-with-idiopathic-pulmonary-arterial-hypertension
#9
Yi Tang, Qin Luo, Zhihong Liu, Xiuping Ma, Zhihui Zhao, Zhiwei Huang, Liu Gao, Qi Jin, Changming Xiong, Xinhai Ni
BACKGROUND: Few published studies have evaluated the power of the oxygen uptake efficiency slope (OUES) to predict outcomes in patients with idiopathic pulmonary arterial hypertension (IPAH), who typically die of right-sided heart failure. Our study sought to evaluate the power of OUES to predict clinical worsening and mortality in patients with IPAH. METHODS AND RESULTS: Patients with newly diagnosed IPAH who underwent symptom-limited cardiopulmonary exercise testing from November 11, 2010, to June 25, 2015, in our hospital were prospectively enrolled and followed for up to 66 months...
June 30, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28663375/sexually-dimorphic-skeletal-muscle-and-cardiac-dysfunction-in-a-mouse-model-of-limb-girdle-muscular-dystrophy-2i
#10
Joseph W Maricelli, Denali R Kagel, Yemeserach M Bishaw, O Lynne Nelson, David C Lin, Buel D Rodgers
The fukutin-related protein P448L mutant mouse replicates pathologies common to limb-girdle muscular dystrophy 2i (LGMD2i) and is a strong candidate for relevant drug screening studies. Because striated muscle function remains relatively uncharacterized in this mouse, we sought to identify metabolic, functional and histological metrics of exercise and cardiac performance by quantifying voluntary exercise on running wheels, forced exercise on respiratory treadmills and cardiac output with echocardiography and isoproterenol stress tests...
June 29, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28652535/clinical-application-of-ghrelin-for-chronic-respiratory-failure
#11
Nobuhiro Matsumoto, Hironobu Tsubouchi, Yoshifumi Imazu, Yasuji Arimura, Shigehisa Yanagi, Hirotoshi Iiboshi, Masamitsu Nakazato
Chronic respiratory failure, which is often caused by chronic obstructive pulmonary disease, chronic lower respiratory tract infection, or interstitial pneumonia, often leads to cachexia with disease progression. Patients who have chronic respiratory failure with cachexia exhibit increased morbidity. Although cachectic status is an important clinical problem, there are no effective therapies for cachexia. Ghrelin has various effects, including increasing food intake, attenuating sympathetic nerve activity, inhibiting inflammation, increasing cardiac output, and controlling fat utilization...
2017: Endocrine Journal
https://www.readbyqxmd.com/read/28646812/oral-consumption-of-vitamin-k2-for-8-weeks-associated-with-increased-maximal-cardiac-output-during-exercise
#12
Brian K McFarlin, Andrea L Henning, Adam S Venable
Background • Vitamin K1 and K2 are not typically common in a Western diet because they are found in a variety of fermented foods. Vitamin K2 in particular has been demonstrated to restore mitochondrial function and has a key role in production of mitochondrial adenosine triphosphate. Thus, it is reasonable to speculate that dietary supplementation with vitamin K2 could increase the function of muscle with high mitochondrial content (ie, skeletal and cardiac muscle). Objective • The purpose of this study was to determine if 8 wk of dietary supplementation with Vitamin K2 could alter cardiovascular responses to a graded cycle ergometer test...
July 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28624095/fontan-circulation-over-time
#13
Djoeke Wolff, Joost P van Melle, Beatrijs Bartelds, Floris-Jan S Ridderbos, Graziella Eshuis, Elisabeth B H J van Stratum, Salvador J Recinos, Brigitte W M Willemse, Hans Hillege, Tineke P Willems, Tjark Ebels, Rolf M F Berger
The unique, unphysiological Fontan circulation is associated with an impaired functional status of the patients that is suggested to deteriorate over time. Unfortunately, previous studies did not integrate both pulmonary and cardiac determinants of functional status. In addition, a comparison with the natural decrease in exercise capacity in healthy subjects (in both children and adults) is lacking. This single-center study aims to investigate the functional status in a cohort of Fontan patients in relation to time since Fontan completion and to identify its determinants, including cardiac characteristics and pulmonary characteristics...
August 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28620310/abdominal-binding-improves-neuromuscular-efficiency-of-the-human-diaphragm-during-exercise
#14
Sara J Abdallah, David S Chan, Robin Glicksman, Cassandra T Mendonca, Yuanming Luo, Jean Bourbeau, Benjamin M Smith, Dennis Jensen
We tested the hypothesis that elastic binding of the abdomen (AB) would enhance neuromuscular efficiency of the human diaphragm during exercise. Twelve healthy non-obese men aged 24.8 ± 1.7 years (mean ± SE) completed a symptom-limited constant-load cycle endurance exercise test at 85% of their peak incremental power output with diaphragmatic electromyography (EMGdi) and respiratory pressure measurements under two randomly assigned conditions: unbound control (CTRL) and AB sufficient to increase end-expiratory gastric pressure (Pga,ee) by 5-8 cmH2O at rest...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28614793/a-single-dose-of-cannabidiol-reduces-blood-pressure-in-healthy-volunteers-in-a-randomized-crossover-study
#15
Khalid A Jadoon, Garry D Tan, Saoirse E O'Sullivan
BACKGROUND: Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid used in multiple sclerosis and intractable epilepsies. Preclinical studies show CBD has numerous cardiovascular benefits, including a reduced blood pressure (BP) response to stress. The aim of this study was to investigate if CBD reduces BP in humans. METHODS: Nine healthy male volunteers were given 600 mg of CBD or placebo in a randomized, placebo-controlled, double-blind, crossover study. Cardiovascular parameters were monitored using a finometer and laser Doppler...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28607162/impact-of-age-on-the-association-between-cardiac-high-energy-phosphate-metabolism-and-cardiac-power-in-women
#16
Maria Nathania, Kieren G Hollingsworth, Matthew Bates, Christopher Eggett, Michael I Trenell, Lazar Velicki, Petar M Seferovic, Guy A MacGowan, Doug M Turnbull, Djordje G Jakovljevic
OBJECTIVE: Diminished cardiac high-energy phosphate metabolism (phosphocreatine-to-ATP (PCr:ATP) ratio) and cardiac power with age may play an important roles in development of cardiac dysfunction and heart failure. The study defines the impact of age on PCr:ATP ratio and cardiac power and their relationship. METHODS: Thirty-five healthy women (young≤50 years, n=20; and old≥60 years, n=15) underwent cardiac MRI with (31)P spectroscopy to assess PCr:ATP ratio and performed maximal graded cardiopulmonary exercise testing with simultaneous gas-exchange and central haemodynamic measurements...
June 12, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28577680/results-of-a-phase-i-ii-multi-center-investigation-of-udenafil-in-adolescents-after-fontan-palliation
#17
David J Goldberg, Victor Zak, Bryan H Goldstein, Shan Chen, Michelle S Hamstra, Elizabeth A Radojewski, Eileen Maunsell, Seema Mital, Shaji C Menon, Kurt R Schumacher, R Mark Payne, Mario Stylianou, Jonathan R Kaltman, Tina M deVries, James L Yeager, Stephen M Paridon
BACKGROUND: The Fontan operation results in a circulation that is dependent on low pulmonary vascular resistance to maintain an adequate cardiac output. Medical therapies that lower pulmonary vascular resistance may augment cardiac output and improve long-term outcomes. OBJECTIVES: This phase I/II clinical trial conducted by the Pediatric Heart Network was designed to evaluate short-term safety, pharmacokinetics (PK), and preliminary efficacy of udenafil in adolescents following Fontan...
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28574213/comparison-of-cardiac-output-estimates-by-bioreactance-and-inert-gas-rebreathing-methods-during-cardiopulmonary-exercise-testing
#18
Nduka C Okwose, Shakir Chowdhury, David Houghton, Michael I Trenell, Christopher Eggett, Matthew Bates, Guy A MacGowan, Djordje G Jakovljevic
PURPOSE: This study assessed the agreement between cardiac output estimated by inert gas rebreathing and bioreactance methods at rest and during exercise. METHODS: Haemodynamic measurements were assessed in 20 healthy individuals (11 females, nine males; aged 32 ± 10 years) using inert gas rebreathing and bioreactance methods. Gas exchange and haemodynamic data were measured simultaneously under rest and different stages (i.e. 30, 60, 90, 120, 150 and 180 W) of progressive graded cardiopulmonary exercise stress testing using a bicycle ergometer...
June 2, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28570840/sex-differences-in-the-oxygen-delivery-extraction-and-uptake-during-moderate-walking-exercise-transition
#19
Thomas Beltrame, Rodrigo Villar, Richard L Hughson
Previous studies in children and older adults demonstrated faster oxygen uptake (V̇O2) kinetics in males compared with females, but young healthy adults have not been studied. We hypothesized that young men would have faster aerobic system dynamics in response to the onset of exercise than women. Interactions between oxygen supply and utilization were characterized by the dynamics of V̇O2, deoxyhemoglobin (HHb), tissue saturation index (TSI), cardiac output (Q̇), and calculated arteriovenous O2 difference (a-vO2diff) in women and men...
June 1, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28566737/sex-specific-cardiopulmonary-exercise-testing-parameters-as-predictors-in-patients-with-idiopathic-pulmonary-arterial-hypertension
#20
Ping Yuan, Hui-Juan Ni, Tian-Xiang Chen, Bigyan Pudasaini, Rong Jiang, Hui Liu, Qin-Hua Zhao, Lan Wang, Su-Gang Gong, Jin-Ming Liu
Cardiopulmonary exercise testing (CPET) has been used for prognosis in idiopathic pulmonary arterial hypertension (IPAH). We explored whether sex differences had an impact on prognostic assessments of CPET in IPAH. Data were retrieved from 21 male and 36 female incident IPAH patients who underwent both right heart catheterization and CPET from 2010 to 2016 at Shanghai Pulmonary Hospital. Cox proportional hazards analysis was used to assess the prognostic value of CPET. The mean duration of follow-up was 22±15 months...
June 1, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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