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https://www.readbyqxmd.com/read/29761310/characteristics-of-patients-with-a-relatively-greater-minimum-ve-vco-2-against-peak-vo-2-and-impaired-exercise-tolerance
#1
Taisuke Nakade, Hitoshi Adachi, Makoto Murata, Shigeru Oshima
PURPOSE: Cardiopulmonary exercise testing (CPX) is used to evaluate functional capacity and assess prognosis in cardiac patients. Ventilatory efficiency (VE/VCO2 ) reflects ventilation-perfusion mismatch; the minimum VE/VCO2 value (minVE/VCO2 ) is representative of pulmonary arterial blood flow in individuals without pulmonary disease. Usually, minVE/VCO2 has a strong relationship with the peak oxygen uptake (VO2 ), but dissociation can occur. Therefore, we investigated the relationship between minVE/VCO2 and predicted peak VO2 (peak VO2 %) and evaluated the parameters associated with a discrepancy between these two parameters...
May 14, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29761224/cardiopulmonary-factors-affecting-6-min-walk-distance-in-patients-with-idiopathic-inflammatory-myopathies
#2
Naoki Mugii, Fujiko Someya
Idiopathic inflammatory myopathies involve skeletal muscles and can be associated with interstitial lung disease and/or heart dysfunction, which may reduce exercise capacity. We aimed to clarify cardiopulmonary factors affecting the 6-min walk distance in patients who were able to walk without leg pain or fatigue. Twenty-three patients with inactive adult idiopathic inflammatory myopathies, and 18 age- and gender-matched healthy controls were evaluated for hemodynamic responses using noninvasive impedance cardiography during the 6-min walk test...
May 14, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29756296/effect-of-obesity-on-oxygen-uptake-and-cardiovascular-dynamics-during-whole-body-and-leg-exercise-in-adult-males-and-females
#3
Simon Green, Eamon O'Connor, Catherine Kiely, Donal O'Shea, Mikel Egaña
Obesity has been associated with a slowing of V˙O2 dynamics in children and adolescents, but this problem has not been studied in adults. Cardiovascular mechanisms underlying this effect are not clear. In this study, 48 adults (18 males, 30 females) grouped according to body mass index (BMI) (lean < 25 kg·m-2 , overweight = 25-29.9 kg·m-2 , obese ≥30 kg·m-2 ) provided a fasting blood sample, completed a maximal graded exercise test and six bouts of submaximal exercise on a cycle ergometer, and performed two protocols of calf exercise...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29745006/effects-of-acute-intradialytic-exercise-on-cardiovascular-responses-in-hemodialysis-patients
#4
Jin Hee Jeong, Annabel Biruete, Bo Fernhall, Kenneth R Wilund
BACKGROUND: In patients with kidney failure requiring hemodialysis (HD) treatment, intradialytic exercise (IDEX) has been advocated for its feasibility and effectiveness in improving important health outcomes. However, IDEX as an adjunct therapeutic strategy is infrequently implemented, in part due to potential risks of IDEX, especially in patients with chronic volume overload. This study was performed to evaluate the safety of IDEX performed at different time points by examining its effect on intradialytic cardiovascular hemodynamics...
May 9, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29721510/evaluation-of-skeletal-muscle-function-and-effects-of-early-rehabilitation-during-acute-heart-failure-rationale-and-study-design
#5
Kinga Węgrzynowska-Teodorczyk, Agnieszka Siennicka, Krystian Josiak, Robert Zymliński, Monika Kasztura, Waldemar Banasiak, Piotr Ponikowski, Marek Woźniewski
Background: Acute heart failure (AHF) is associated with disturbances of the peripheral perfusion leading to the dysfunction of many organs. Consequently, an episode of AHF constitutes a "multiple organ failure" which may also affect the skeletal muscles. However, the abnormalities within skeletal muscles during AHF have not been investigated so far. The aim of this project is to comprehensively evaluate skeletal muscles (at a functional and tissue level) during AHF. Methods: The study will include ≥63 consecutive AHF patients who will be randomized into 2 groups: ≥42 with cardiac rehabilitation group versus ≥21 with standard pharmacotherapy alone...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29719514/longer-work-rest-intervals-during-high-intensity-interval-training-hiit-lead-to-elevated-levels-of-mir-222-and-mir-29c
#6
Boris Schmitz, Florian Rolfes, Katrin Schelleckes, Mirja Mewes, Lothar Thorwesten, Michael Krüger, Andreas Klose, Stefan-Martin Brand
Aim: MicroRNA-222 (miR-222) and miR-29c have been identified as important modulators of cardiac growth and may protect against pathological cardiac remodeling. miR-222 and -29c may thus serve as functional biomarkers for exercise-induced cardiac adaptations. This investigation compared the effect of two workload-matched high-intensity interval training (HIIT) protocols with different recovery periods on miR-222 and -29c levels. Methods: Sixty-three moderately trained females and males (22.0 ± 1.7 years) fulfilled the eligibility criteria and were randomized into two HIIT groups using sex and exercise capacity...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29713818/right-ventriculo-arterial-uncoupling-and-impaired-contractile-reserve-in-obese-patients-with-unexplained-exercise-intolerance
#7
Colm McCabe, Rudolf K F Oliveira, Farbod Rahaghi, Mariana Faria-Urbina, Luke Howard, Richard G Axell, Andrew N Priest, Aaron B Waxman, David M Systrom
BACKGROUND: Right ventricular (RV) dysfunction and heart failure with preserved ejection fraction may contribute to exercise intolerance in obesity. To further define RV exercise responses, we investigated RV-arterial coupling in obesity with and without development of exercise pulmonary venous hypertension (ePVH). METHODS: RV-arterial coupling defined as RV end-systolic elastance/pulmonary artery elastance (Ees/Ea) was calculated from invasive cardiopulmonary exercise test data in 6 controls, 8 obese patients without ePVH (Obese-ePVH) and 8 obese patients with ePVH (Obese+ePVH) within a larger series...
April 30, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29704163/respiratory-sinus-arrhythmia-in-the-immediate-post-exercise-period-correlation-with-breathing-specific-heart-rate
#8
Jacopo P Mortola, Domnica Marghescu, Rosmarie Siegrist-Johnstone
BACKGROUND: Although the absolute values of pulmonary ventilation and cardiac output are similar, the designs of the respiratory and cardiovascular systems imply major differences in flow patterns, airflow being intermittent by comparison to the quasi-continuous pulmonary blood flow. PURPOSE: We hypothesized that respiratory sinus arrhythmia (RSA, difference in heart rate (fH ) between inspiration and expiration, as percent of mean fH ) ameliorates the inevitable differences between air- and blood-flow patterns...
April 27, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29703223/comparison-of-exercise-intensity-during-four-early-rehabilitation-techniques-in-sedated-and-ventilated-patients-in-icu-a-randomised-cross-over-trial
#9
Clément Medrinal, Yann Combret, Guillaume Prieur, Aurora Robledo Quesada, Tristan Bonnevie, Francis Edouard Gravier, Elise Dupuis Lozeron, Eric Frenoy, Olivier Contal, Bouchra Lamia
BACKGROUND: In the ICU, out-of-bed rehabilitation is often delayed and in-bed exercises are generally low-intensity. Since the majority of rehabilitation is carried out in bed, it is essential to carry out the exercises that have the highest intensity. The aim of this study was to compare the physiological effects of four common types of bed exercise in intubated, sedated patients confined to bed in the ICU, in order to determine which was the most intensive. METHODS: A randomised, single-blind, placebo-controlled crossover trial was carried out to evaluate the effects of four bed exercises (passive range of movements (PROM), passive cycle-ergometry, quadriceps electrical stimulation and functional electrical stimulation (FES) cycling) on cardiac output...
April 27, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29695381/pulmonary-capillary-wedge-pressure-patterns-during-exercise-predict-exercise-capacity-and-incident-heart-failure
#10
Aaron S Eisman, Ravi V Shah, Bishnu P Dhakal, Paul P Pappagianopoulos, Luke Wooster, Cole Bailey, Thomas F Cunningham, Kathryn M Hardin, Aaron L Baggish, Jennifer E Ho, Rajeev Malhotra, Gregory D Lewis
BACKGROUND: Single measurements of left ventricular filling pressure at rest lack sensitivity for identifying heart failure with preserved ejection fraction (HFpEF) in patients with dyspnea on exertion. We hypothesized that exercise hemodynamic measurements (ie, changes in pulmonary capillary wedge pressure [PCWP] indexed to cardiac output [CO]) may more sensitively differentiate HFpEF and non-HFpEF disease states, reflect aerobic capacity, and forecast heart failure outcomes in individuals with normal PCWP at rest...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29693431/maximum-heart-rate-does-not-limit-cardiac-output-at-rest-or-during-exercise-in-the-american-alligator-alligator-mississippiensis
#11
William Joyce, Ruth M Elsey, Tobias Wang, Dane A Crossley Nd
In most vertebrates, increases in cardiac output result from increases in heart rate (fH ) with little or no change in stroke volume (Vs), and maximum cardiac output (Q̇) is typically attained at or close to maximum fH . We therefore tested the hypothesis that increasing maximum fH may increase maximum Q̇. To this end, we investigated the effects of elevating fH with right atrial pacing on Q̇ in the American alligator (Alligator mississippiensis) at rest and whilst swimming. During normal swimming, Q̇ increased entirely by virtue of a tachycardia (29 {plus minus} 1 to 40 {plus minus} 3 beats min-1 ) whilst Vs remained stable...
April 25, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29687266/physiological-and-psychological-determinants-of-whole-body-endurance-exercise-following-short-term-sustained-operations-with-partial-sleep-deprivation
#12
Michail E Keramidas, Magnus Gadefors, Lars-Ove Nilsson, Ola Eiken
PURPOSE: The study examined the effects of short-term field-based military training with partial sleep deprivation on whole-body endurance performance in well-trained individuals. METHODS: Before and after a 2-day sustained operations (SUSOPS), 14 cadets performed a 15-min constant-load cycling at 65% of peak power output (PPO; CLT65 ), followed by an exhaustive constant-load trial at 85% of PPO (CLT85 ). Physiological [oxygen uptake ([Formula: see text]O2 ), heart rate (HR), mean arterial pressure (MAP), cardiac output (CO), and regional oxygenation (TOI) in the frontal cerebral cortex and vastus lateralis muscle] and psychological [effort perception (RPE), affective valence (FS), and perceived activation (FAS)] variables were monitored during exercise...
April 23, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29683391/grape-seed-extract-supplementation-attenuates-the-blood-pressure-response-to-exercise-in-prehypertensive-men
#13
Jong-Kyung Kim, Kyung-Ae Kim, Hyun-Min Choi, Seung-Kook Park, Charles L Stebbins
We tested the hypothesis that exaggerated pressor responses observed in prehypertensive males (N = 9) during dynamic exercise are attenuated following acute dietary supplementation with grape seed extract (GSE) (i.e., a single dose). Effects of placebo and GSE (300 mg) on systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), cardiac output (CO), stroke volume (SV), total vascular conductance (TVC), and rate × pressure product (RPP) in response to two submaximal cycling workloads (40% and 60% VO2peak ) were compared 2 h after ingestion of GSE or placebo on different days, 1 week apart...
April 23, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29650544/evaluation-and-management-of-right-sided-heart-failure-a-scientific-statement-from-the-american-heart-association
#14
REVIEW
Marvin A Konstam, Michael S Kiernan, Daniel Bernstein, Biykem Bozkurt, Miriam Jacob, Navin K Kapur, Robb D Kociol, Eldrin F Lewis, Mandeep R Mehra, Francis D Pagani, Amish N Raval, Carey Ward
BACKGROUND AND PURPOSE: The diverse causes of right-sided heart failure (RHF) include, among others, primary cardiomyopathies with right ventricular (RV) involvement, RV ischemia and infarction, volume loading caused by cardiac lesions associated with congenital heart disease and valvular pathologies, and pressure loading resulting from pulmonic stenosis or pulmonary hypertension from a variety of causes, including left-sided heart disease. Progressive RV dysfunction in these disease states is associated with increased morbidity and mortality...
May 15, 2018: Circulation
https://www.readbyqxmd.com/read/29650336/acute-physiological-responses-to-low-intensity-blood-flow-restriction-cycling
#15
H J Thomas, B R Scott, J J Peiffer
OBJECTIVES: Blood flow restriction (BFR) during interval cycling may stimulate aerobic and anaerobic adaptations. However, acute physiological responses to BFR interval cycling have not been extensively investigated. DESIGN: Eighteen males completed low-intensity (LI), low-intensity with BFR (LIBFR ) and high-intensity (HI) interval cycling sessions in randomised and counterbalanced order. These included a standardised warm-up and three two-min intervals interspersed with two-min recovery...
April 9, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29629733/exercise-hemodynamics-for-the-diagnosis-of-diastolic-dysfunction-in-dyspneic-patients-with-systemic-sclerosis
#16
Anne Graham Cummiskey, Amit Segev, Michael Segel, Jonathan Buber, Victor Guetta, Israel M Barbash, Dan Elian, Elad Asher, Ori Vaturi, Paul Fefer
OBJECTIVES: To assess the added diagnostic value of using exercise hemodynamics during RHC in assessment of patients with symptomatic SSc. METHODS: We performed 22 RHCs in 17 SSc patients with dyspnea and/or pulmonary arterial hypertension (PAH). Exercise was performed in 15 RHCs using isotonic arm exercises while holding a 1 kg weight in each hand. Measurements of pulmonary arterial pressure (PAP), pulmonary arterial wedge pressure (PAWP), and cardiac output (CO) were taken at rest and during peak exercise...
April 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29603461/metaboreceptor-activation-in-heart-failure-with-reduced-ejection-fraction-linking-cardiac-and-peripheral-vascular-hemodynamics
#17
Zachary Barrett-O'Keefe, Joshua F Lee, Amanda Berbert, Melissa A H Witman, Jose Nativi-Nicolau, Josef Stehlik, Russell S Richardson, D Walter Wray
This study sought to evaluate the muscle metaboreflex in heart failure patients with reduced ejection fraction (HFrEF), with an emphasis on the interaction between cardiac and peripheral vascular hemodynamics across multiple levels of metaboreceptor activation. In 23 HFrEF patients (63 ± 2 yrs) and 15 healthy controls (64 ± 3 yrs), we examined changes in mean arterial pressure (MAP), cardiac output (CO), systemic vascular conductance (SVC), effective arterial elastance (Ea), stroke work (SW), and forearm deoxyhemoglobin concentration during metaboreceptor activation elicited by post-exercise circulatory occlusion (PECO) following three levels of static-intermittent handgrip exercise (15, 30, and 45% maximal voluntary contraction (MVC))...
March 30, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29600086/exercise-training-in-pulmonary-arterial-hypertension
#18
REVIEW
Laura Adelaide Dalla Vecchia, Maurizio Bussotti
Pulmonary arterial hypertension (PAH) is characterized by a continuous increase in pre-capillary pulmonary vascular resistance (PVR) with a progressive reduction of cardiac output (CO). Similar to what occurs in left heart failure (HF), this represents the initial phase of a syndrome characterized by the progressive development of dyspnea and fatigue with increasing deterioration of exercise tolerance. Although the therapies introduced in the last two decades have determined a significant improvement of the clinical conditions of PAH patients, they have a little impact on exercise capacity and prognosis...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29590559/decreased-prefrontal-oxygenation-elicited-by-stimulation-of-limb-mechanosensitive-afferents-during-cycling-exercise
#19
Ryota Asahara, Kanji Matsukawa
Our laboratory reported using near-infrared spectroscopy that feedback from limb mechanoafferents may decrease prefrontal oxygenated-hemoglobin concentration (Oxy-Hb) during the late period of voluntary and passive cycling. To test the hypothesis that the decreased Oxy-Hb of the prefrontal cortex would be augmented depending on the extent of limb mechanoafferent input, the prefrontal Oxy-Hb response was measured during motor-driven one- and two-legged passive cycling for 1 min at various revolutions of pedal movement in 19 subjects...
March 28, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29570598/effects-of-resistance-training-on-cardiovascular-function-in-patients-with-peripheral-artery-disease-a-randomized-controlled-trial
#20
Ana P F Gomes, Marilia A Correia, Antônio H G Soares, Gabriel G Cucato, Aluísio H R A Lima, Bruno R Cavalcante, Dário C Sobral-Filho, Raphael M Ritti-Dias
Gomes, APF, Correia, MA, Soares, AHG, Cucato, GG, Lima, AHRA, Cavalcante, BR, Sobral-Filho, DC, and Ritti-Dias, RM. Effects of resistance training on cardiovascular function in patients with peripheral artery disease: A randomized controlled trial. J Strength Cond Res 32(4): 1072-1080, 2018-The aim of this study was to analyze the effects of resistance training on cardiovascular function of patients with peripheral artery disease (PAD). In total, 30 patients with PAD were invited to participate in this randomized controlled trial, randomly allocated to a control (n = 15, 66 ± 2 years; stretching and relaxation exercises) or resistance training group (n = 15, 60 ± 3 years; 3 sets of 10 repetitions of 8 whole-body exercises, with a 2-minute interval between sets)...
April 2018: Journal of Strength and Conditioning Research
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