Alexandra Jamieson, Lamia Al Saikhan, Lamis Alghamdi, Lee Hamill Howes, Helen Purcell, Toby Hillman, Melissa Heightman, Thomas Treibel, Michele Orini, Robert Bell, Marie Scully, Mark Hamer, Nishi Chaturvedi, Hugh Montgomery, Alun D Hughes, Ronan Astin, Siana Jones
The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS-CoV-2 virus ("long COVID") is not fully understood. Cases were recruited from a long COVID clinic (N = 32; 44 ± 12 years; 10 (31%) men), and age-/sex-matched healthy controls (HC) (N = 19; 40 ± 13 years; 6 (32%) men) from University College London staff and students. We assessed exercise performance, lung and cardiac function, vascular health, skeletal muscle oxidative capacity, and autonomic nervous system (ANS) function...
February 2024: Physiological Reports