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Asanka Jayawardane, Malitha Patabendige, Dulani Samaranayake, Medini Boteju, Shamalka Dahanayake, Ruvini Perera, Sumudu Jayasinghe, Dakshila Galappatti, C N Wijeyaratne
AIM: To study case mix, risk factors, adverse outcomes and associations of hyperglycemia in pregnancy in a cohort of Sri Lankans. METHODS: Prospective observational study, from April 2011-October 2015 at a tertiary care referral center, Colombo, Sri Lanka. Data from first trimester to delivery of HIP was analyzed. Three subgroups were defined: Diabetes in pregnancy (DIP), Hyperglycemia in early Pregnancy (HIEP) [<24 weeks] and Gestational diabetes (GDM) [>24 weeks]...
March 8, 2018: Diabetes Research and Clinical Practice
Napoleon N Ekem, Lucky O Lawani, Robinson C Onoh, Chukwuemeka A Iyoke, Leonard O Ajah, Emeka O Onwe, Azubuike K Onyebuchi, Love C Okafor
Preconception care (PCC) is a preventive strategy for maternal and perinatal morbidity and mortality. This study aimed to assess the level of awareness and utilisation of PCC services. A descriptive cross-sectional survey was conducted at a teaching hospital. Interviewer-administered questionnaires were used to extract information. A total of 450 participants responded; 44.2% (190/450) were aware, 31.7% (143/450) had good knowledge, while only 10.3% (46/450) received PCC. Health care providers were the main source of information (77...
March 12, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Ali Khatibi, Anne-Marie Nybo Andersen, Mika Gissler, Nils-Halvdan Morken, Bo Jacobsson
OBJECTIVES: Childbearing at extremely advanced maternal age is a globally increasing trend, but only a few studies have described the outcomes of these pregnancies. The aim of this study was to describe the occurrence of childbearing at age 50 and up in the Nordic countries, as well as to examine the frequency of adverse obstetric and neonatal outcomes. STUDY DESIGN: A descriptive population-based study was designed. Data from 1991 to 2013 were collected from the Medical Birth Registries in Denmark, Finland, Norway and Sweden...
March 3, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Ida Donkin, Romain Barrès
BACKGROUND: Developmental programming of the embryo is controlled by genetic information but also dictated by epigenetic information contained in spermatozoa. Lifestyle and environmental factors not only influence health in one individual but can also affect the phenotype of the following generations. This is mediated via epigenetic inheritance i.e., gametic transmission of environmentally-driven epigenetic information to the offspring. Evidence is accumulating that preconceptional exposure to certain lifestyle and environmental factors, such as diet, physical activity, and smoking, affects the phenotype of the next generation through remodeling of the epigenetic blueprint of spermatozoa...
February 27, 2018: Molecular Metabolism
Michael Ibrahim, Audrey E Spelde, Timothy I Carter, Prakash A Patel, Nimesh Desai
The normal aortic valve is a sophisticated and dynamic structure whose equal replacement has not yet been actualized by modern technology. The use of the pulmonary autograft as a substitute for a diseased aortic valve (the Ross procedure) has been in practice for several decades in many types of patient. In the adult, it has not been adopted widely due to concerns about its technical challenge, complex perioperative care, the development of pulmonic valve disease, and concerns about long-term dilatation of the neo-aortic root, among others...
December 29, 2017: Journal of Cardiothoracic and Vascular Anesthesia
Lorenzo Cecchi, Gennaro D'Amato, Isabella Annesi-Maesano
Allergies are complex diseases that result from interactions between multiple genetic and environmental factors. However, the increase in allergies observed in the past decades is explained exclusively by environmental changes occurring in the same period. Presently, the exposome, the totality of specific and nonspecific external environmental exposures (external exposome) to which a subject is exposed from preconception onward and their consequences at the organ and cell levels (internal exposome), is being considered to explain the inception, development, and exacerbations of allergic diseases...
March 2018: Journal of Allergy and Clinical Immunology
S A van Nederveen-Bendien, S R J van Oord-Bosselaar, A H Feitsma, J H Kappen
- Asthma during pregnancy is associated with an increased risk of preterm delivery, low birth weight and pre-eclampsia.- This condition may be undertreated due to insufficient knowledge and, in particular, concerns about teratogenic effects of asthma medication among treating healthcare professionals and pregnant women.- The risk of teratogenic effects of inhaled medications (ICS, SABA and LABA) is small. These agents have been used by large groups of patients for many years.- Well-controlled asthma with pharmacological therapy during pregnancy is safer and leads to fewer complications then accepting asthma symptoms and exacerbations...
2018: Nederlands Tijdschrift Voor Geneeskunde
Amy Peacock, Delyse Hutchinson, Judy Wilson, Clare McCormack, Raimondo Bruno, Craig A Olsson, Steve Allsop, Elizabeth Elliott, Lucinda Burns, Richard P Mattick
The aims of this study were to identify: (i) the proportion of women exceeding the caffeine intake guideline (>200 mg/day) during each trimester, accounting for point of pregnancy awareness; (ii) guideline adherence trajectories across pregnancy; (iii) maternal characteristics associated with trajectories; and (iv) association between adherence and growth restriction birth outcomes. Typical and maximal intake per consumption day for the first trimester (T1; pre- and post-pregnancy awareness), second (T2), and third trimester (T3) were recorded for a prospective cohort of pregnant Australian women with singleton births ( n = 1232)...
March 7, 2018: Nutrients
Austin C Korgan, Elizabeth O'Leary, Jillian L King, Ian C G Weaver, Tara S Perrot
Paternal preconception risk factors (e.g. stress, diet, drug use) correlate with metabolic dysfunction in offspring, which is often comorbid with depressive and anxiety-like phenotypes. Detection of these risk factors or deleterious phenotypes informs a female about prevailing ecological demands, in addition to potential adverse environment-induced phenotypes that may be disseminated to her offspring. We examined whether a F0 male rat's prior exposure to an obesogenic high-fat diet (HFD) influences a female's attraction towards a male, subsequent mother-infant interactions and the development of defensive (emotional) responses in the F1 offspring...
February 21, 2018: Psychoneuroendocrinology
Natalia Ignaszak-Kaus, Katarzyna Ozegowska, Piotr Piekarski, Leszek Pawelczyk, Piotr Jędrzejczak
OBJECTIVES: Preconception counseling, maternal health-related habits, diet, folic acid consumption, substances abuse, may all impact the outcome of pregnancy. The aim of this study was to compare the planning and preparation for pregnancy among pregnant women with and without infertility. MATERIAL AND METHODS: A survey of health behaviors prior to and during pregnancy that could affect pregnancy outcomes, including laboratory tests performed, stimulant usage, initiation of prenatal care, and folic acid intake, was conducted among 400 pregnant women...
2018: Ginekologia Polska
Sarah Armstrong, Michael Wammes, Justin Arcaro, Amanda Hostland, Carolyn Summerhurst, Elizabeth Osuch
AIM: To compare young adults' expectations of psychiatric treatment to their actual experiences and identify myths and assumptions that youth might hold prior to receiving care. METHODS: We interviewed youth who engaged in at least 4 months of treatment at the First Episode Mood and Anxiety Program to theme saturation (N = 20). They were asked about their experience of treatment and the expectations they had prior to care. Transcribed interviews were analysed for themes...
March 7, 2018: Early Intervention in Psychiatry
Jessica E Morse, Merry-K Moos
Introduction Unintended pregnancy has been a concerning public health problem for decades. As we begin to understand the complexities of pregnancy intention and how women experience these pregnancies, reproductive life planning offers a paradigm shift. Methods Reproductive life planning is a patient-centered approach that places a patient's reproductive preferences-whether concrete or ambivalent-at the forefront of her clinical care. Results This process grants women and men the opportunity to consider how reproduction fits within the context of their broader lives...
March 6, 2018: Maternal and Child Health Journal
Hiroki Shimodaira, Keiji Tensho, Yusuke Akaoka, Suguru Koyama, Masaaki Maruyama, Hiroyuki Kato, Naoto Saito
BACKGROUND: The acetabular fossa is thought to be located in the center of the acetabulum, and acetabular reaming in total hip arthroplasty is conventionally performed in the center of the fossa. However, the actual location of the fossa and the influence that hypoplasia or deformity may have on the position of the fossa are unknown. We hypothesized that the fossa is located in the center of the acetabulum, regardless of hypoplasia or deformity. METHODS: Fifty patients with normal hips (normal hip group), 50 patients with dysplasia who underwent rotational acetabular osteotomy (dysplastic hip group), and 46 patients with osteoarthritis who underwent total hip arthroplasty (osteoarthritic hip group) were evaluated by computed tomography (CT) imaging...
March 7, 2018: Journal of Bone and Joint Surgery. American Volume
Caroline T Nguyen, Elizabeth B Sasso, Lorayne Barton, Jorge H Mestman
Background: Graves' hyperthyroidism affects 0.2% of pregnant women. Establishing the correct diagnosis and effectively managing Graves' hyperthyroidism in pregnancy remains a challenge for physicians. Main: The goal of this paper is to review the diagnosis and management of Graves' hyperthyroidism in pregnancy. The paper will discuss preconception counseling, etiologies of hyperthyroidism, thyroid function testing, pregnancy-related complications, maternal management, including thyroid storm, anti-thyroid drugs and the complications for mother and fetus, fetal and neonatal thyroid function, neonatal management, and maternal post-partum management...
2018: Clinical Diabetes and Endocrinology
Heidi Kammerlander, Jan Nielsen, Jens Kjeldsen, Torben Knudsen, Kim Oren Gradel, Sonia Friedman, Bente Mertz Nørgård
Background: Fecal calprotectin (FC) is a biomarker used for assessing disease activity among IBD patients. Sparse knowledge exists as to whether FC correlates with clinical disease activity during pregnancy. Our aim was to assess FC and selected biomarkers in women with moderate-severe IBD and correlate them with clinical disease activity scores in pregnant women. Methods: We identified a nationwide cohort of 219 singleton pregnancies in women with moderate-severe disease (all treated with anti-tumor recrosis factor-α [anti-TNF-α] therapy during pregnancy), and we reviewed the medical records to extract clinical details and information on biomarkers...
February 28, 2018: Inflammatory Bowel Diseases
Qiao-Yu Jiang, Jue Li, Liang Zheng, Guang-Hua Wang, Jing Wang
BACKGROUND: This study investigates the constitution of traditional Chinese medicine (TCM) among women who want to be pregnant in one year and explores factors related to TCM constitution. METHODS: This study was conducted on women who participated in free preconception check-ups provided by the Zhabei District Maternity and Child Care Center in Shanghai, China. The information regarding the female demographic characteristics, physical condition, history of pregnancy and childbearing, diet and behavior, and social psychological factors was collected, and TCM constitution assessment was performed...
March 1, 2018: Journal of the Chinese Medical Association: JCMA
Brigitte Ramsauer, Sandra Achtergarde
BACKGROUND: Maternal postpartum psychoses pose a serious risk to the mother-infant interaction. It is unclear how different subtypes of postpartum psychosis, including acute and chronic, might differentially affect the mother-infant interaction. METHOD: A systematic search of electronic journal databases was performed. RESULTS: This systematic review yielded 17 studies with adequate overall study quality. They focused on child custody and involvement of social services as indirect indicators of the mother-infant interaction, observed mother-infant interactions as direct indicators, or potential transitional mechanisms, including memory processing, mind-mindedness, and affect recognition, that may partially explain the effects of psychotic disorders...
February 26, 2018: Schizophrenia Research
Grzegorz Józef Nowicki, Patrycja Misztal-Okońska, Barbara Ślusarska, Ewa Rudnicka-Drożak, Magdalena Młynarska, Artur Czekierdowski
Preconception lifestyle modifications and reduction of several known risk factors may have an influence on future pregnancy outcomes. The aim of the study was to analyze health behaviors and personal values as well as to assess the relationship between these factors in women without children, in pregnant women and in women who had already delivered babies. The questionnaire survey included the Health Behavior Inventory (HBI), the Personal Value List (PVL) and sociodemographic data and was conducted in 538 women...
February 27, 2018: International Journal of Environmental Research and Public Health
Courtney D Lynch, Rajeshwari Sundaram, Germaine M Buck Louis
STUDY QUESTION: Are biomarkers of preconception stress associated with pregnancy loss? SUMMARY ANSWER: Preconception stress, as measured by basal salivary cortisol and alpha-amylase concentrations, is not associated with pregnancy loss. WHAT IS KNOWN ALREADY: Many studies, most of which have been retrospective, have identified an association between stressful life events and perceived stress and miscarriage. STUDY DESIGN, SIZE, DURATION: A prospective pregnancy study with preconception enrollment was conducted between 2005 and 2009...
February 27, 2018: Human Reproduction
Olina Dagher, Nassiba Alami Laroussi, Michel Carrier, Renzo Cecere, Eric Charbonneau, Simon de Denus, Nadia Giannetti, Line Leduc, Bernard Cantin, Asmaa Mansour, Nancy Poirier, Marie-Josée Raboisson, Michel White, Anique Ducharme
BACKGROUND: Despite reports of successful pregnancies in heart transplant (HTx) recipients, many centers recommend their patients against maternity. METHODS: We reviewed our provincial experience of pregnancy in HTx recipient by performing charts review of all known gestations following HTx in the province of Quebec (Canada), stratified between planned and unplanned pregnancies. Long-term survival was compared to HTx recipient women of childbearing age who didn't become pregnant...
February 26, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
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