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Preconception

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https://www.readbyqxmd.com/read/28719055/endocrine-toxicity-of-immune-checkpoint-inhibitors-essential-crosstalk-between-endocrinologists-and-oncologists
#1
REVIEW
Frédéric Illouz, Claire Briet, Lucie Cloix, Yannick Le Corre, Nathalie Baize, Thierry Urban, Ludovic Martin, Patrice Rodien
Two types of immune checkpoint inhibitors, both antibodies that target cytotoxic T-lymphocyte antigen-4 and those that target programmed cell death-protein 1, have been approved for use in melanoma, non-small-cell lung cancer, and renal cell carcinoma as first-line or second-line therapy. Their adverse events are primarily regarded as immune-related adverse events. We felt it was important to pinpoint and discuss certain preconceptions or misconceptions regarding thyroid dysfunction, hypophysitis, and diabetes induced by immune checkpoint inhibitors...
July 18, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28711073/lupus-nephritis-and-pregnancy-concerns-and-management
#2
Liz Lightstone, Michelle A Hladunewich
Pregnancy associated with lupus, especially lupus nephritis, is often fraught with concern for both the mother and fetus. Thus, it is paramount that care begins preconception so that proper planning in terms of optimizing the medical regimen, discontinuation of fetotoxic agents, and treatment of active disease can occur. It is well known that active nephritis at the time of conception is associated with poor outcomes. Even with quiescent disease, recent data indicate that being lupus anticoagulant-positive, nonwhite or Hispanic, and using antihypertensive medications were all predictors of worse pregnancy outcomes...
July 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28708254/preconceptional-folic-acid-supplementation-in-japan
#3
Fumiki Hirahara, Haruka Hamanoue, Kentaro Kurasawa
Since 2000, preconceptional folic acid supplementation has been recommended in Japan. In Japan, lack of active campaign and attitude of women for folic acid intake has retained behind situation as compared to western countries. In the present review, we traced past and present practice and discuss the issues surrounding folate intake both before and after conception.
July 14, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28697912/screening-brief-intervention-and-referral-to-treatment-for-opioid-and-other-substance-use-during-infertility-treatment
#4
REVIEW
Tricia E Wright
Opioid use and misuse have reached epidemic proportions in the United States, especially in women of childbearing age, some of whom seek infertility treatments. Substance use is much more common than many of the conditions routinely screened for during the preconception period, and it can have devastating consequences for the woman and her family. Substance use can worsen infertility, complicate pregnancy, increase medical problems, and lead to psychosocial difficulties for the woman and her family. The reproductive endocrinologist thus has an ethical and medical duty to screen for substance use, provide initial counseling, and refer to specialized treatment as needed...
July 8, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28697118/finding-middle-ground-in-constructing-a-clinically-useful-expanded-carrier-screening-panel
#5
Blair Stevens, Nevena Krstic, Malorie Jones, Lauren Murphy, Jennifer Hoskovec
Expanded carrier screening for autosomal-recessive conditions effectively identifies more carrier couples than traditional guideline-based carrier screening. However, clinically available expanded carrier screening panels include numerous conditions, some of which have questionable clinical utility as a result of very low carrier frequency, low or unknown testing sensitivity, and mild or incompletely penetrant phenotypes. Using the 2013 American College of Medical Genetics and Genomics Position Statement on Prenatal and Preconception Expanded Carrier Screening and the 2017 American College of Obstetricians and Gynecologists' Committee Opinion on Carrier Screening in the Age of Genomic Medicine as guidance, we propose specific criteria for the development of expanded carrier screening panels that will maximize clinical utility and minimize patient stress, unnecessary cost of follow-up testing, and clinician time spent facilitating and performing follow-up counseling and testing...
July 7, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28694524/prevalence-of-overweight-and-obesity-in-15-8-million-men-aged-15-49-years-in-rural-china-from-2010-to-2014
#6
Yuan He, An Pan, Yuanyuan Wang, Ying Yang, Jihong Xu, Ya Zhang, Dujia Liu, Qiaomei Wang, Haiping Shen, Yiping Zhang, Donghai Yan, Zuoqi Peng, Frank B Hu, Xu Ma
Obesity has been increasing worldwide. Data on obesity status among men of reproductive age are scarce. This study aimed to assess the national prevalence and trend of overweight and obesity among reproductive-age men in rural China. In the nationwide population-based study, data were obtained from the National Free Preconception Health Examination Project in rural China from 2010 to 2014. Weight and height were measured in 16 161 982 men aged 15-49 years and their female partners (15 997 739 participants aged 15-49 years) before conception, and body mass index (BMI) was calculated...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28694019/opportunities-to-reduce-diabetes-risk-in-women-of-reproductive-age-assessment-and-treatment-of-prediabetes-within-a-large-integrated-delivery-system
#7
Cassondra Marshall, Sara Adams, Wendy Dyer, Julie Schmittdiel
BACKGROUND: Preventing diabetes before pregnancy may be important to improve maternal and infant outcomes. Although the preconception period is a crucial time to focus on chronic disease prevention, little is known about preventive services for reproductive-aged women at risk of developing diabetes. METHODS: Using electronic health record data from patients at Kaiser Permanente Northern California, we identified 21,965 nonpregnant women aged 18 to 44 with incident prediabetes (PDM; fasting plasma glucose [FPG] = 100-125 or glycated hemoglobin A1c = 5...
July 7, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28693619/successful-pregnancy-after-mucinous-cystic-neoplasm-with-invasive-carcinoma-of-the-pancreas-in-a-patient-with-polycystic-ovarian-syndrome-a-case-report
#8
Conisha Holloman, S J Carlan, Lohini Sundharkrishnan, Angela Guzman, Mario Madruga
BACKGROUND: The incidence of invasive cancer within a mucinous cystic neoplasm of the pancreas varies between 6 and 36%. Polycystic ovarian syndrome is a disorder characterized by hyperandrogenism and anovulatory infertility. One surgical treatment that can restore endocrine balance and ovulation in polycystic ovarian syndrome is partial ovarian destruction. Successful pregnancies following preconception pancreaticoduodenectomies (Whipple procedures) and chemoradiation to treat pancreatic neoplasms have been reported rarely but none were diagnosed with pre-cancer polycystic ovarian syndrome-associated infertility...
July 11, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28688924/healthy-preconception-nutrition-and-lifestyle-using-personalized-mobile-health-coaching-is-associated-with-enhanced-pregnancy-chance
#9
Matthijs R van Dijk, Maria P H Koster, Sten P Willemsen, Nicole A Huijgen, Joop S E Laven, Régine P M Steegers-Theunissen
Periconceptional nutrition and lifestyle are essential in pathogenesis and prevention of most reproductive failures, pregnancy outcome and future health. We aimed to investigate whether personalized mobile health (mHealth) coaching empowers couples contemplating pregnancy to increase healthy behaviour and chances of pregnancy. A survey was conducted among 1053 women and 332 male partners who received individual coaching using the mHealth programme 'Smarter Pregnancy' to change poor nutrition and lifestyle for 26 weeks, depending on pregnancy state and gender...
June 27, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28678065/pregnancy-and-reproductive-aspects-of-systemic-lupus-erythematosus
#10
Laura Andreoli, Francesca Crisafulli, Angela Tincani
PURPOSE OF REVIEW: To discuss pregnancy and reproductive aspects in women with systemic lupus erythematosus (SLE) with particular focus on preconception counselling, maternal and foetal outcomes, safety and beneficial effects of drugs during pregnancy as well as contraception methods, assisted reproduction techniques and strategies for thromboembolism prophylaxis in patients with positive antiphospholipid antibodies. RECENT FINDINGS: Evidence-based recommendations for the management of family planning and women's health issues in SLE and/or APS have been developed by a multidisciplinary panel of experts...
July 3, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28670549/medication-counseling-for-thyroxine
#11
Sanjay Kalra, A G Unnikrishnan, Mangesh Tiwaskar, Rakesh Sahay, Banshi Saboo, Vijay Negalur, Deepak Khandelwal, Pritam Gupta, Sujoy Ghosh, A K Das, Ganapathi Bantwal, Sarita Bajaj, Sameer Agarwal, Rashmi Aggarwal, Navneet Agarwal
This communication from the National Indian Patient-centered Thyroid Management group provides a useful tool to help in medication counseling during hypothyroidism management. The authors classify and list aspects of thyroxine use which must be discussed with patients on thyroxine supplementation or replacement. Issues related to concomitant food and medications intake, preconception and pregnancy management, as well as sick day care, are also discussed.
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28666241/paternal-and-maternal-urinary-phthalate-metabolite-concentrations-and-birth-weight-of-singletons-conceived-by-subfertile-couples
#12
Carmen Messerlian, Joseph M Braun, Lidia Mínguez-Alarcón, Paige L Williams, Jennifer B Ford, Vicente Mustieles, Antonia M Calafat, Irene Souter, Thomas Toth, Russ Hauser
BACKGROUND: Prenatal phthalate exposure has been inconsistently associated with fetal growth and infant birth weight. However, the effect of exposure during the paternal and maternal preconception period remains understudied. OBJECTIVES: To investigate associations of paternal and maternal preconception and maternal prenatal urinary phthalate metabolite concentrations with birth weight. METHODS: The study comprised 364 singletons born to 364 mothers and 195 fathers (195 couples) from the EARTH Study, a prospective cohort of couples from Boston, MA...
June 27, 2017: Environment International
https://www.readbyqxmd.com/read/28666192/preventing-obesity-across-the-preconception-pregnancy-and-postpartum-cycle-implementing-research-into-practice
#13
Cheryce L Harrison, Helen Skouteris, Jacqueline Boyle, Helena J Teede
No abstract text is available yet for this article.
June 15, 2017: Midwifery
https://www.readbyqxmd.com/read/28664328/timeline-of-intergenerational-child-maltreatment-the-mind-brain-body-interplay
#14
REVIEW
Marija Mitkovic Voncina, Milica Pejovic Milovancevic, Vanja Mandic Maravic, Dusica Lecic Tosevski
PURPOSE OF REVIEW: Still obscure mechanisms of intergenerational child maltreatment (ITCM) have been investigated partially, from various psychological and biological perspectives and from various time perspectives. This review is aimed at integrating the findings on different temporal ITCM pathways, emphasizing the mind-brain-body interplay. RECENT FINDINGS: Psychological mediators of ITCM involve attachment, mentalization, dissociation, social information processing, personality traits, and psychiatric disorders...
August 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28660887/association-between-hypertensive-disorders-of-pregnancy-and-the-risk-of-postpartum-hypertension-a-cohort-study-in-women-with-gestational-diabetes
#15
L Wang, J Leng, H Liu, S Zhang, J Wang, W Li, W Li, N Li, T Zhang, A A Baccarelli, L Hou, X Yang, Z Yu, G Hu
Previous studies in general people indicated that hypertensive disorders of pregnancy (HDP) increased the risk of subsequent hypertension after delivery. Some studies found that women with gestational diabetes mellitus (GDM) had an increased risk of HDP. However, very few studies have assessed the association between HDP and the risk of postpartum hypertension among GDM women. To evaluate the association between HDP and the risk of postpartum hypertension among GDM women, a retrospective cohort study was conducted in 1261 women with prior GDM at their postpartum 1-5 years using the baseline data from Tianjin Gestational Diabetes Mellitus Prevention Program...
June 29, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28657892/plasma-perfluoroalkyl-and-polyfluoroalkyl-substances-concentration-and-menstrual-cycle-characteristics-in-preconception-women
#16
Wei Zhou, Lulu Zhang, Chuanliang Tong, Fang Fang, Shasha Zhao, Ying Tian, Yexuan Tao, Jun Zhang
BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are persistent synthetic chemicals that are widely used in industrial applications and often detectable in humans. In rats, PFASs can interfere with the estrous cycle. In humans, menstruation has been viewed as a proxy of female fecundity, and periodic menstruation plays a critical role in endometrial sloughing in the absence of pregnancy and in preparing for embryo implantation. OBJECTIVES: We investigated the association between PFAS exposure and menstrual cycle characteristics in women who plan to become pregnant...
June 22, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28650842/ambient-temperature-and-stillbirth-a-multi-center-retrospective-cohort-study
#17
Sandie Ha, Danping Liu, Yeyi Zhu, Sung Soo Kim, Seth Sherman, Katherine L Grantz, Pauline Mendola
BACKGROUND: Climate change is expected to have adverse health effects, but the association between extreme ambient temperatures and stillbirth is unclear. OBJECTIVES: We investigated acute and chronic associations between extreme ambient temperatures and stillbirth risk, and estimated the attributable risk associated with local temperature extremes in the United States. METHODS: We linked 223,375 singleton births of gestation (2002-2008) from 12 U...
June 22, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28647972/-relationship-between-pesticide-exposure-and-adverse-pregnancy-outcomes-among-reproductive-couples-in-rural-areas-of-china
#18
Y M Qu, S Chen, J J Li, R R Jin, H Pan, Y Jiang
Objective: To analyze the association between pesticide exposure and adverse pregnancy outcomes in women from the rural areas of China. Methods: Data of "National Free Preconception Health Examination Project (NFPHEP)" from January 2010 to December 2012 was used for analysis. A total of 248 501 families that were planning to deliver a baby in the next 6 months were enrolled. Data on paternal exposure to pesticides before or during pregnancy was collected through questionnaires, with related outcomes on pregnancy recorded by doctors...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28647897/varicocele-and-semen-quality-a-retrospective-case-control-study-of-4230-patients-from-a-single-centre
#19
F Pallotti, D Paoli, T Carlini, A R Vestri, G Martino, A Lenzi, F Lombardo
PURPOSE: The aim of the present study is to assess impairment of spermatogenesis induced by varicocele in, to our knowledge, the largest single-centre caseload available to date. MATERIALS AND METHODS: We conducted a retrospective study on 4230 consecutive patients attending our Department for andrological outpatient assessment and preconception check-ups between 2011 and 2014. A total of 2113 patients had varicocele (Group V), while the remaining 2117 were selected as the control group (Group C)...
June 24, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28641469/the-effect-of-counselling-on-preconception-lifestyle-and-awareness-in-iranian-women-contemplating-pregnancy-a-randomized-control-trial
#20
Sakineh Ghasemi Yngyknd, Sakineh Mohammad-Alizadeh-Charandabi, Jalil Babapour, Mojgan Mirghafourvand
PURPOSE: This study was conducted to determine the effect of counselling on preconception lifestyle and awareness about it in healthy women planning to get pregnant. METHODS: This study was conducted on 152 women aged 18-35 who planned to get pregnant within the next year. Using block randomization, the participants were assigned into a counselling and a control group (n=76 per group). The intervention group attended six group counselling sessions, twice per week, over 3 weeks...
June 22, 2017: Journal of Maternal-fetal & Neonatal Medicine
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