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https://www.readbyqxmd.com/read/29922060/a-review-of-ketamine-s-role-in-ect-and-non-ect-settings
#1
REVIEW
Vytautas Jankauskas, Candace Necyk, James Chue, Pierre Chue
Up to 20% of depressed patients demonstrate treatment resistance to one or more adequate antidepressant trials, resulting in a disproportionately high burden of illness. Ketamine is a non-barbiturate, rapid-acting general anesthetic that has been increasingly studied in treatment resistant depression (TRD), typically at sub-anesthetic doses (0.5 mg/kg over 40 min by intravenous infusion). More recent data suggest that ketamine may improve response rates to electroconvulsive therapy (ECT) when used as an adjunct, but also as a sole agent...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29916196/recent-trends-in-the-practice-of-procedural-sedation-under-local-anesthesia-for-catheter-ablation-gastrointestinal-endoscopy-and-endoscopic-surgery-in-japan-a-retrospective-database-study-in-clinical-practice-from-2012-to-2015
#2
Akiko Matsui, Michihiro Morimoto, Hiroshi Suzuki, Thomas Laurent, Yoko Fujimoto, Yoshimi Inagaki
OBJECTIVES: To investigate changes in sedation practice during 2012-2015, using a large health claims database, for catheter ablation (CA), gastrointestinal endoscopic examination (EE), and surgery (ES) after dexmedetomidine (DEX) was approved for procedural sedation in 2013. We assessed the trends of sedative utilization, sedative-analgesic combinations, and, additionally, incidence of complications from 2012 to 2015. METHODS: Using the database provided by Medical Data Vision Co...
June 18, 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29913863/whiplash-associated-disorders-wad-responses-to-pharmacological-challenges-and-psychometric-tests
#3
Mats Persson, Jan Sörensen, Björn Gerdle
Objectives The present study challenges chronic Whiplash Associated Disorders (WAD)-subjects to a pharmacological intravenous (i.v.) test with morphine, ketamine, and active placebo (midazolam). The aim was to describe the short-term responses to drugs and the assumed heterogeneity in the patterns of responses. We related the different responder groups to the results from psychometric tests. Methods The study includes 95 patients, all with chronic WAD and referred to our departments. They answered a questionnaire including the following psychometric instruments relevant for chronic pain: Beck Depression Inventory, Coping Strategies Questionnaire, Multidimensional Pain Inventory, Life Satisfaction Checklist, SF36 and EuroQol...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29912788/maintenance-ketamine-therapy-for-treatment-resistant-depression
#4
Shaina Archer, Carson Chrenek, Jennifer Swainson
BACKGROUND: Previous studies have demonstrated ketamine to have a rapid antidepressant effect in some patients with treatment-resistant depression (TRD), but the effect is unfortunately not sustained in the long term. In this study, we report on the clinical use of ongoing maintenance ketamine infusions in a group of patients with TRD, beyond an acute course of 6 to 8 ketamine infusions. METHODS: This retrospective case series reports on 11 patients with TRD who received maintenance ketamine infusions, defined as treatments beyond an initial series of up to 8 infusions...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29907742/nmda-antagonists-for-treating-the-non-motor-symptoms-in-parkinson-s-disease
#5
REVIEW
Brigitte Vanle, William Olcott, Jaime Jimenez, Luma Bashmi, Itai Danovitch, Waguih William IsHak
Among patients with Parkinson's disease (PD), depression is prevalent and disabling, impacting both health outcomes and quality of life. There is a critical need for alternative pharmacological methods to treat PD depression, as mainstream antidepressant drugs are largely ineffective in this population. Currently, there are no recommendations for the optimal treatment of PD neuropsychiatric symptoms. Given the dual antidepressant and anti-dyskinetic effects of ketamine and other N-methyl-D-aspartate (NMDA) antagonists for PD, this review aims to examine the current evidence of NMDA antagonists for treating neuropsychiatric symptoms, including memantine, amantadine, ketamine, dizoclopine, and d-cycloserine...
June 15, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29905575/ce-original-research-the-efficacy-and-safety-of-an-rn-driven-ketamine-protocol-for-adjunctive-analgesia-during-burn-wound-care
#6
Laura Baumgartner, Nicole Townsend, Katie Winkelman, Robert MacLaren
Findings indicate that adjunctive low-dose ketamine was safe and provided pain relief. ABSTRACT: Objectives: Traditional analgesic regimens often fail to control the severe pain patients experience during burn wound care, and the drugs are frequently administered at doses that can cause oversedation and respiratory depression. Ketamine may be an ideal agent for adjunctive analgesia in such patients because of its unique mechanism of action and lack of association with respiratory depression...
June 13, 2018: American Journal of Nursing
https://www.readbyqxmd.com/read/29899972/ketamine-and-rapid-acting-antidepressants-a-new-era-in-the-battle-against-depression-and-suicide
#7
REVIEW
Ronald S Duman
Therapeutic medications for the treatment of depression have serious limitations, particularly delayed onset and low rates of efficacy. However, the discovery that a single subanesthetic dose of ketamine, a glutamate NMDA receptor channel blocker, can produce a rapid (within hours) antidepressant response that is sustained (about 1 week), even in patients considered treatment-resistant, has invigorated the field. In addition to these remarkable actions, ketamine has proven effective for the treatment of suicidal ideation...
2018: F1000Research
https://www.readbyqxmd.com/read/29899695/intravascular-ketamine-increases-theta-burst-but-not-high-frequency-tetanus-induced-ltp-at-ca3-ca1-synapses-within-three-hours-and-devoid-of-an-increase-in-spine-density
#8
Allie J Widman, Amy E Stewart, Elise M Erb, Elizabeth Gardner, Lori L McMahon
In the past 20 years, ketamine has become a promising treatment for Major Depressive Disorder (MDD) due to its rapid and sustain antidepressant effects in patients. A single ketamine treatment causes improvement in depressive symptoms within hours and can last weeks, long after it is eliminated. Previous studies have demonstrated increased synaptic plasticity at CA3-CA1 synapses in hippocampus (HPC) 24 h post ketamine treatment suggesting increased activity-dependent hippocampal function may underlie the antidepressant effects of ketamine...
2018: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/29898390/psychedelics-promote-structural-and-functional-neural-plasticity
#9
Calvin Ly, Alexandra C Greb, Lindsay P Cameron, Jonathan M Wong, Eden V Barragan, Paige C Wilson, Kyle F Burbach, Sina Soltanzadeh Zarandi, Alexander Sood, Michael R Paddy, Whitney C Duim, Megan Y Dennis, A Kimberley McAllister, Kassandra M Ori-McKenney, John A Gray, David E Olson
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast-acting antidepressant properties of the dissociative anesthetic ketamine. Here, we report that, like ketamine, serotonergic psychedelics are capable of robustly increasing neuritogenesis and/or spinogenesis both in vitro and in vivo. These changes in neuronal structure are accompanied by increased synapse number and function, as measured by fluorescence microscopy and electrophysiology...
June 12, 2018: Cell Reports
https://www.readbyqxmd.com/read/29895894/nmdar-independent-camp-dependent-antidepressant-actions-of-ketamine
#10
Nathan H Wray, Jeffrey M Schappi, Harinder Singh, Nicolas B Senese, Mark M Rasenick
Ketamine produces rapid and robust antidepressant effects in depressed patients within hours of administration, often when traditional antidepressant compounds have failed to alleviate symptoms. We hypothesized that ketamine would translocate Gαs from lipid rafts to non-raft microdomains, similarly to other antidepressants but with a distinct, abbreviated treatment duration. C6 glioma cells were treated with 10 µM ketamine for 15 min, which translocated Gαs from lipid raft domains to non-raft domains...
June 12, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29895202/the-effect-of-route-of-administration-on-the-enantioselective-pharmacokinetics-of-ketamine-and-norketamine-in-rats
#11
Martin Le Nedelec, Paul Glue, Helen Winter, Chelsea Goulton, Natalie J Medlicott
BACKGROUND: Ketamine has been shown to produce a rapid and potent antidepressant response in patients with treatment-resistant depression. Currently ketamine is most commonly administered as a 40-minute intravenous infusion, though it is unknown whether this is the optimal route of administration. AIMS: To determine the plasma concentration time course of the R- and S-enantiomers of ketamine and norketamine following administration of ketamine by four different routes of administration...
June 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29879390/overcoming-depression-by-inhibition-of-neural-burst-firing
#12
Daesoo Kim, Eunji Cheong, Hee-Sup Shin
The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression.
June 6, 2018: Neuron
https://www.readbyqxmd.com/read/29867602/cognitive-and-neurophysiological-recovery-following-electroconvulsive-therapy-a-study-protocol
#13
Ben J A Palanca, Hannah R Maybrier, Angela M Mickle, Nuri B Farber, R Edward Hogan, Emma R Trammel, J Wylie Spencer, Donald D Bohnenkamp, Troy S Wildes, ShiNung Ching, Eric Lenze, Mathias Basner, Max B Kelz, Michael S Avidan
Electroconvulsive therapy (ECT) employs the elective induction of generalizes seizures as a potent treatment for severe psychiatric illness. As such, ECT provides an opportunity to rigorously study the recovery of consciousness, reconstitution of cognition, and electroencephalographic (EEG) activity following seizures. Fifteen patients with major depressive disorder refractory to pharmacologic therapy will be enrolled (Clinicaltrials.gov, NCT02761330). Adequate seizure duration will be confirmed following right unilateral ECT under etomidate anesthesia...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29867368/nitrous-oxide-induces-prominent-cell-proliferation-in-adult-rat-hippocampal-dentate-gyrus
#14
Farah Chamaa, Hisham F Bahmad, Ahmad-Kareem Makkawi, Reda M Chalhoub, Elie D Al-Chaer, George B Bikhazi, Ziad Nahas, Wassim Abou-Kheir
The identification of distinct and more efficacious antidepressant treatments is highly needed. Nitrous oxide (N2 O) is an N-methyl-D-aspartic acid (NMDA) antagonist that has been reported to exhibit antidepressant effects in treatment-resistant depression (TRD) patients. Yet, no studies have investigated the effects of sub-anesthetic dosages of N2 O on hippocampal cell proliferation and neurogenesis in adult brain rats. In our study, adult male Sprague-Dawley rats were exposed to single or multiple exposures to mixtures of 70% N2 O and 30% oxygen (O2 )...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29864611/the-profile-of-cognitive-impairments-in-chronic-ketamine-users
#15
Xiaoyin Ke, Yi Ding, Ke Xu, Hongbo He, Daping Wang, Xuefeng Deng, Xifan Zhang, Yanling Zhou, Chao Zhou, Yuping Liu, Yuping Ning, Ni Fan
The aim of this study was to examine the cognitive function in chronic ketamine users. Factors correlated to cognition impairments were analyzed. Sixty-three chronic ketamine users and 65 healthy subjects were recruited. Cognitive function was assessed by using immediate/delayed visual reproduction (IVR/DVR) tasks, immediate/delayed logical memory (ILM/DLM) tasks, Stroop test, Wisconsin card sorting test (WCST), and continuous performance test (CPT). Psychopathological symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI)...
May 26, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29859882/the-impact-of-sex-as-a-biological-variable-in-the-search-for-novel-antidepressants
#16
REVIEW
Alexia V Williams, Brian C Trainor
A roadblock to successful treatment for anxiety and depression is the high proportion of individuals that do not respond to existing treatments. Different underlying neurobiological mechanisms may drive similar symptoms, so a more personalized approach to treatment could be more successful. There is increasing evidence that sex is an important biological variable modulating efficacy of antidepressants and anxiolytics. We review evidence for sex-specific effects of traditional monoamine based antidepressants and newer pharmaceuticals targeting kappa opioid receptors (KOR), oxytocin receptors (OTR), and N-methyl-D-aspartate receptors (ketamine)...
May 31, 2018: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29851879/mood-disorders
#17
Jeffrey Rakofsky, Mark Rapaport
PURPOSE OF REVIEW: This article discusses the prevalence of the major mood disorders (major depressive disorder and bipolar disorder) in the community and within neurologic settings, articulates the steps taken to make a diagnosis of major depressive disorder or bipolar disorder, and reviews old and newer treatment options with proven efficacy for the treatment of these two conditions. RECENT FINDINGS: New medications are available as treatment options for major depressive disorder and bipolar disorder, such as intranasal and IV ketamine, and somatic treatments, such as deep brain stimulation and vagal nerve stimulators, are being used to target treatment-resistant depression...
June 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29847468/ketamine-anesthesia-does-not-improve-depression-scores-in-electroconvulsive-therapy-a-randomized-clinical-trial
#18
Charles William Carspecken, Anna Borisovskaya, Shu-Tsui Lan, Katherine Heller, Jonathan Buchholz, David Ruskin, Irene Rozet
BACKGROUND: Although interest in ketamine use during electroconvulsive therapy (ECT) has increased, studies have been equivocal with regard to its efficacy. The aims of this clinical trial were to evaluate ketamine's antidepressive effects in ECT as a primary anesthetic, determine ketamine's tolerability when compared with standard anesthesia, and determine if plasma brain-derived neurotrophic factor (BDNF) is necessary for treatment response. MATERIALS AND METHODS: Adults meeting criteria for treatment-resistant depression undergoing index course ECT received either methohexital (1 to 2 mg/kg) or ketamine (1 to 2 mg/kg) anesthesia in this dual-arm double-blinded randomized clinical trial (NCT02752724)...
May 25, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29803629/the-neurobiology-of-depression-ketamine-and-rapid-acting-antidepressants-is-it-glutamate-inhibition-or-activation
#19
REVIEW
Chadi G Abdallah, Gerard Sanacora, Ronald S Duman, John H Krystal
The discovery of the antidepressant effects of ketamine has opened a breakthrough opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants (RAADs). In addition, the rapid and robust biological and behavioral effects of ketamine offered a unique opportunity to utilize the drug as a tool to thoroughly investigate the neurobiology of stress and depression in animals, and to develop sensitive and reproducible biomarkers in humans. The ketamine literature over the past two decades has considerably enriched our understanding of the mechanisms underlying chronic stress, depression, and RAADs...
May 25, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29802366/-2r-6r-hydroxynorketamine-is-not-essential-for-the-antidepressant-actions-of-r-ketamine-in-mice
#20
Jun-Ichi Yamaguchi, Hidetoh Toki, Youge Qu, Chun Yang, Hiroyuki Koike, Kenji Hashimoto, Akiko Mizuno-Yasuhira, Shigeyuki Chaki
(R,S)-Ketamine has rapid and sustained antidepressant effects in depressed patients. Although the metabolism of (R,S)-ketamine to (2 R,6 R)-hydroxynorketamine (HNK), a metabolite of (R)-ketamine, has been reported to be essential for its antidepressant effects, recent evidence suggests otherwise. The present study investigated the role of the metabolism of (R)-ketamine to (2 R,6 R)-HNK in the antidepressant actions of (R)-ketamine. Antidepressant effects were evaluated using the forced swimming test in the lipopolysaccharide (LPS)-induced inflammation model of mice and the tail suspension test in naive mice...
May 3, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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