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https://www.readbyqxmd.com/read/29656600/long-term-efficacy-and-safety-of-sucroferric-oxyhydroxide-in-african-american-dialysis-patients
#1
Stuart M Sprague, Markus Ketteler, Adrian C Covic, Jürgen Floege, Viatcheslav Rakov, Sebastian Walpen, Anjay Rastogi
INTRODUCTION: Sucroferric oxyhydroxide (SFOH) is a non-calcium, iron-based phosphate binder that demonstrated sustained serum phosphorus (sP) control, good tolerability, and lower pill burden, vs. sevelamer carbonate ("sevelamer"), in a Phase 3 study conducted in dialysis patients with hyperphosphatemia. This analysis evaluates the efficacy and safety of SFOH and sevelamer among African American (AA) patients participating in the trial. METHODS: Post hoc analysis of a 24-week, Phase 3, open-label trial (NCT01324128) and its 28-week extension study (NCT01464190)...
April 15, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29656500/mitochondria-glycogen-and-lipid-droplets-in-skeletal-muscle-during-testosterone-treatment-and-strength-training-a-randomized-double-blinded-placebo-controlled-trial
#2
R C Jensen, L L Christensen, J Nielsen, H D Schrøder, T Kvorning, K Gejl, K Højlund, D Glintborg, M Andersen
Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double-blinded, placebo-controlled study, we investigated the effects of six-month testosterone replacement therapy (TRT) and strength training (ST) on mitochondrial, glycogen, and lipid droplet (LD) content in skeletal muscle of aging men with subnormal bioavailable testosterone (BioT) levels...
April 15, 2018: Andrology
https://www.readbyqxmd.com/read/29656433/antifibrinolytics-for-heavy-menstrual-bleeding
#3
REVIEW
Alison C Bryant-Smith, Anne Lethaby, Cindy Farquhar, Martha Hickey
BACKGROUND: Heavy menstrual bleeding (HMB) is an important physical and social problem for women. Oral treatment for HMB includes antifibrinolytic drugs, which are designed to reduce bleeding by inhibiting clot-dissolving enzymes in the endometrium.Historically, there has been some concern that using the antifibrinolytic tranexamic acid (TXA) for HMB may increase the risk of venous thromboembolic disease. This is an umbrella term for deep venous thrombosis (blood clots in the blood vessels in the legs) and pulmonary emboli (blood clots in the blood vessels in the lungs)...
April 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29656430/individual-differences-in-stop-related-activity-are-inflated-by-the-adaptive-algorithm-in-the-stop-signal-task
#4
Nicholas D'Alberto, Bader Chaarani, Catherine A Orr, Philip A Spechler, Matthew D Albaugh, Nicholas Allgaier, Alexander Wonnell, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Patricia J Conrod, Sylvane Desrivières, Herta Flor, Juliane H Fröhner, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Itterman, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Trevor W Robbins, Michael N Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Alexandra S Potter, Hugh Garavan
Research using the Stop Signal Task employing an adaptive algorithm to accommodate individual differences often report inferior performance on the task in individuals with ADHD, OCD, and substance use disorders compared to non-clinical controls. Furthermore, individuals with deficits in inhibitory control tend to show reduced neural activity in key inhibitory regions during successful stopping. However, the adaptive algorithm systematically introduces performance-related differences in objective task difficulty that may influence the estimation of individual differences in stop-related neural activity...
April 15, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29656405/the-cellie-coping-kit-for-children-with-injury-initial-feasibility-acceptability-and-outcomes
#5
M L Marsac, D Weiss, K L Kohser, J Van Allen, P Seegan, S Ostrowski-Delahanty, A McGar, F K Winston, N Kassam-Adams
PURPOSE: Physical and psychological challenges can arise from paediatric injury, which can impact child health outcomes. Evidence-based resources to promote recovery are limited. The low cost, portable Cellie Coping Kit for Children with Injury provides evidence-based strategies to help children manage injury-related challenges. This study aimed to describe intervention feasibility and explore initial outcomes (learning, quality of life [QOL], and trauma symptoms). METHODS: Three independent pilot studies were conducted...
April 15, 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29656373/evaluation-of-disease-activity-in-patients-with-rheumatoid-arthritis-treated-with-tofacitinib-by-rapid3-post-hoc-analyses-from-two-phase-3-trials
#6
Vibeke Strand, Eun Bong Lee, Yusuf Yazici, Ara Dikranian, Bethanie Wilkinson, Liza Takiya, Chuanbo Zang, Eustratios Bananis, Martin J Bergman
Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. We evaluated the relationship between disease activity, according to Routine Assessment of Patient Index Data 3 (RAPID3) after 6-month treatment with tofacitinib, and long-term outcomes at 24 months. This was a post hoc analysis of two 24-month, phase 3, randomized controlled trials in methotrexate (MTX)-naïve (ORAL Start [NCT01039688]) or MTX-inadequate responder patients (ORAL Scan [NCT00847613]) receiving tofacitinib 5 or 10 mg twice daily (BID) as monotherapy or with background MTX...
April 14, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29656301/septoplasty-for-nasal-obstruction-due-to-a-deviated-nasal-septum-in-adults-a-systematic-review
#7
M M H T van Egmond, M M Rovers, A H J Tillema, N van Heerbeek
BACKGROUND: The status of current evidence for the effectiveness of septoplasty is unclear. This systematic review evaluates the effectiveness of a) septoplasty (with or without concurrent turbinate surgery) versus non-surgical management, and b) septoplasty with concurrent turbinate surgery versus septoplasty alone, for nasal obstruction due to a deviated nasal septum in adults. METHODOLOGY: Eligible for inclusion were randomised controlled trials and non-randomised designs comparing treatment strategies...
April 15, 2018: Rhinology
https://www.readbyqxmd.com/read/29656279/drug-eluting-resorbable-magnesium-scaffold-implantation-in-st-segment-elevation-myocardial-infarction-a-pilot-study
#8
Quentin de Hemptinne, Fabien Picard, Rachid Briki, Ahmad Awada, Paul-Gaël Silance, Dariouch Dolatabadi, Nadia Debbas, Philippe Unger
OBJECTIVES: To assess feasibility and short-term clinical outcomes associated with resorbable magnesium scaffold (RMS) implantation in the setting of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI). BACKGROUND: RMS implantation has demonstrated favorable clinical outcomes in stable coronary artery disease patients. However, to date, data are lacking in the setting of STEMI. METHODS: This is a single-center prospective non-randomized pilot study...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29656206/enhancing-first-time-parents-self-efficacy-a-systematic-review-and-meta-analysis-of-universal-parent-education-interventions-efficacy
#9
REVIEW
Nur Arina Liyana Amin, Wilson W S Tam, Shefaly Shorey
BACKGROUND: Poor adjustment during early parenthood often leads to low feelings of parental self-efficacy, which influences parents' behaviours towards their infants. The long-term consequences on infant development warrant the need for more attention on the efficacy of universal parent education interventions to empower parents and enhance their self-efficacy. OBJECTIVES: To synthesise available evidence and explore the efficacy of universal parent education interventions on the parental self-efficacy of first-time parents...
March 28, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29656140/outcomes-after-open-and-laparoscopic-appendectomy-during-pregnancy-a-meta-analysis
#10
REVIEW
Anastasia Prodromidou, Nikolaos Machairas, Ioannis D Kostakis, Ernesto Molmenti, Eleftherios Spartalis, Athanasios Kakkos, Georgios T Lainas, Georgios C Sotiropoulos
OBJECTIVES: Acute appendicitis is the most prevalent cause of non-obstetrical surgical disease during pregnancy. There is no consensus on the optimal surgical management of acute appendicitis in pregnancy. Our aim is to identify surgical and obstetrical outcomes of laparoscopic (LA) and open approach (OA) in pregnant patients with acute appendicitis. STUDY DESIGN: Medline, Scopus, Google Scholar, Cochrane CENTRAL Register of Controlled Trials and Clinicaltrials...
April 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29656129/no-difference-in-implant-survivorship-and-clinical-outcomes-between-full-cementless-and-full-cemented-fixation-in-primary-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#11
REVIEW
Kai Zhou, Haoda Yu, Jinglong Li, Haoyang Wang, Zongke Zhou, Fuxing Pei
BACKGROUND: The debate over the use of cemented or cementless fixation in total knee arthroplasty (TKA) has never stopped since cementless fixation was introduced. We undertook a systematic review and meta-analysis to evaluate the optimal mode of fixation (full-cementless vs. full-cemented) in TKA. METHODS: PubMed, Embase, and the Cochrane Library databases up to July 2017 were searched to identify randomised controlled trials (RCTs) and quasi-RCTs comparing full-cementless TKA and full-cemented TKA...
April 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29656127/the-protective-effects-of-taurine-on-oxidative-stress-cytoplasmic-free-ca-2-and-apoptosis-of-pufferfish-takifugu-obscurus-under-low-temperature-stress
#12
Chang-Hong Cheng, Zhi-Xun Guo, An-Li Wang
The present study was aimed to investigate the low temperature toxicity and its protection by taurine in pufferfish. The experimental basal diets supplemented with taurine at the rates of 250 (control), 550, 850, 1140, 1430, 1740 mg kg-1 were fed to fish for 8 weeks. The results showed that fish fed diet with taurine had significantly improved weight gain and specific growth rate. After the feeding trial, the fish were then exposed to low temperature stress. The results showed that low temperature stress could induce reactive oxygen species (ROS) generation, disturb the cytoplasm Ca2+ homeostasis, and lead to oxidative stress and apoptosis...
April 12, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29656002/dangers-of-outpatient-nimodipine-use-after-spontaneous-subarachnoid-hemorrhage-in-accordance-with-the-comprehensive-stroke-center-guidelines
#13
Ching-Jen Chen, Cassie Turnage, Jennifer D Sokolowski, Jeyan S Kumar, M Yashar Kalani, Min S Park
Despite the adverse effects and unclear benefit of the complete 21-day course of nimodipine therapy, The Joint Commission mandates adherence to nimodipine treatment for 21 days after hemorrhage or after hospital discharge if discharged within 21 days for Comprehensive Stroke Center (CSC) certification. We hereby present a 67 year-old male patient with Hunt-Hess grade 2 and Fisher grade 3 non-aneurysmal spontaneous subarachnoid hemorrhage who was discharged with oral nimodipine as stipulated by the CSC guidelines, and subsequently developed symptomatic hypotension...
April 11, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29655955/employment-and-paid-work-among-participants-in-a-randomized-controlled-trial-comparing-diacetylmorphine-and-hydromorphone
#14
Mohammadali Nikoo, Marc Vogel, Fiona Choi, Michael J Song, Jensen Burghardt, Zafar Zafari, Katarina Tabi, Anastasia Frank, Skye Barbic, Christian Schütz, Kerry Jang, Michael Krausz
BACKGROUND: Employment is one of the less studied but a significant outcome of medication-assisted treatment. Thus, we aimed to explore employment outcomes of medication-assisted treatment with hydromorphone (HDM) or diacetylmorphine (DAM). The secondary aim was to estimate characteristics of this population as well as treatment-related factors associated with these outcomes. METHODS: This was a secondary analysis of a randomized, double blind controlled trial. A total of 102 and 100 participants were randomized to receive injectable DAM or HDM for 6 months respectively...
April 12, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29655928/effects-of-3-months-sitting-callisthenic-balance-and-resistance-exercise-on-aerobic-capacity-aortic-stiffness-and-body-composition-in-healthy-older-participants-randomized-controlled-trial
#15
Sławomir Kujawski, Agnieszka Kujawska, Małgorzata Gajos, Jacek J Klawe, Małgorzata Tafil-Klawe, Katarzyna Mądra-Gackowska, Błażej Stankiewicz, Julia L Newton, Kornelia Kędziora-Kornatowska, Paweł Zalewski
BACKGROUND: Arterial stiffness (AS) is a reduction in the ability of large arteries to readily accommodate the increase in blood ejected from the heart during systole related with aging. Physical exercise is associated with AS reduction. However, it remains controversial as to which modality and intensity (resistance vs aerobic, high vs low) would be the most effective. The aim of these studies is to examine the effects of 3-months sitting callisthenic balance (SCB) and resistance exercise (RET) on aerobic capacity, aortic stiffness and body composition in older participants...
April 12, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29655852/aidi-injection-plus-platinum-based-chemotherapy-for-stage-iiib-iv-non-small-cell-lung-cancer-a-meta-analysis-of-42-rcts-following-the-prisma-guidelines
#16
Jue Wang, Guochun Li, Lili Yu, Tingting Mo, Qibiao Wu, Zhou Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Aidi injection is one of the most commonly used Chinese patent medicines for advanced non-small cell lung cancer (NSCLC). It is made from an extraction of Mylabris Phalerata, Radix Astragalus, Radix Ginseng, and Acanthopanax Senticosus. AIM OF THE STUDY: The objective of this study is to evaluate the efficacy and safety of Aidi injection in combination with platinum-based chemotherapy for stage IIIB/IV NSCLC. MATERIALS AND METHODS: A systematic review and meta-analysis were performed following the PRISMA (the Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines...
April 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29655779/postprandial-glucose-and-insulin-response-to-a-high-fiber-muffin-top-containing-resistant-starch-type-4-in-healthy-adults-a-double-blind-randomized-controlled-trial
#17
Maria L Stewart, J Paul Zimmer
OBJECTIVES: VERSAFIBE™ 2470 resistant starch (RS) is an RS type 4 that is derived from high-amylose maize starch,70% total dietary fiber (TDF; AOAC method 2009.01). This was a randomized, double-blind, crossover study to evaluate the postprandial blood glucose and insulin responses of healthy adults (n = 28) after the consumption of a muffin top made with VERSAFIBE™ 2470 RS (11.6 g TDF fiber muffin top) or a control muffin top (0.9 g TDF). METHODS: The muffin tops were matched for weight, total carbohydrate, sugars, protein, and fat...
February 13, 2018: Nutrition
https://www.readbyqxmd.com/read/29655772/predicting-chronic-spontaneous-urticaria-symptom-return-after-omalizumab-treatment-discontinuation-exploratory-analysis
#18
Marta Ferrer, Ana Giménez-Arnau, Diego Saldana, Nico Janssens, Maria-Magdalena Balp, Sam Khalil, Valéry Risson
BACKGROUND: Omalizumab is highly effective in controlling chronic spontaneous urticaria (CSU) symptoms; however, patients can experience symptom return upon treatment discontinuation. Pivotal clinical trials have identified two categories of patients who experience symptom return: rapid and slow. OBJECTIVE: To identify potential predictors of the speed of symptom return after stopping omalizumab treatment. METHODS: Phase III randomized controlled trial (RCT) data from ASTERIA I (n=319; 6x4-weekly injections of omalizumab 75, 150, 300 mg or placebo; NCT01287117) and ASTERIA II (n=323; 3x4-weekly injections of omalizumab 75, 150, 300 mg or placebo; NCT01292473) were pooled to identify predictors of symptom return after stopping omalizumab treatment (16-week follow-up)...
April 12, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29655700/effects-on-oral-fat-load-of-a-nutraceutical-combination-of-fermented-red-rice-sterol-esters-and-stanols-curcumin-and-olive-polyphenols-a-randomized-placebo-controlled-trial
#19
Giuseppe Derosa, Gabriele Catena, Riccardo Raddino, Giovanni Gaudio, Antonio Maggi, Angela D'Angelo, Pamela Maffioli
BACKGROUND: In literature, there are several studies about the effects of nutraceutical combinations at fasting, but data in post-prandial phase are lacking. PURPOSE: We planned a study to evaluate the efficacy and safety of a nutraceutical agent containing fermented red rice, phytosterols and olive polyphenols compared to placebo in a sample of Caucasian patients with low cardiovascular risk, both at fasting and after an oral fat load. STUDY DESIGN: Eighty patients were randomized to receive, as addition to diet and physical activity, a nutraceutical combination containing fermented red rice, sterol esters and stanols, curcumin, and olive polyphenols or placebo (control group), once a day...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655672/effect-of-pulsed-xenon-ultraviolet-room-disinfection-devices-on-microbial-counts-for-methicillin-resistant-staphylococcus-aureus-and-aerobic-bacterial-colonies
#20
John E Zeber, Christopher Pfeiffer, John W Baddley, Jose Cadena-Zuluaga, Eileen M Stock, Laurel A Copeland, Janet Hendricks, Jwan Mohammadi, Marcos I Restrepo, Chetan Jinadatha
BACKGROUND: Inadequate environmental disinfection represents a serious risk for health care-associated infections. Technologic advancements in disinfection practices, including no-touch devices, offer significant promise to improve infection control. We evaluated one such device, portable pulsed xenon ultraviolet (PX-UV) units, on microbial burden during an implementation trial across 4 Veterans Affairs hospitals. METHODS: Environmental samples were collected before and after terminal room cleaning: 2 facilities incorporated PX-UV disinfection into their cleaning protocols and 2 practiced manual disinfection only...
April 11, 2018: American Journal of Infection Control
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