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https://www.readbyqxmd.com/read/27866578/leukocytosis-and-leukemia
#1
REVIEW
Page Widick, Eric S Winer
Leukocytosis is among the most common findings on peripheral blood smear. A wide range of causes may mediate this finding, and careful clinical and laboratory evaluation assist in differentiating between benign and malignant causes of increased white blood cell counts. In this article, various nonmalignant causes are explored, including infectious, inflammatory, autoimmune, and allergic. In addition, malignant causes of leukocytosis are discussed, including myeloproliferative disorders, acute leukemia, and chronic leukemia, as well as treatment and monitoring for patients with these diseases...
December 2016: Primary Care
https://www.readbyqxmd.com/read/27581436/synergistic-neutralization-of-pertussis-toxin-by-a-bispecific-antibody-in-vitro-and-in-vivo
#2
Ellen K Wagner, Xianzhe Wang, Andre Bui, Jennifer A Maynard
Bispecific antibodies are a rapidly growing class of therapeutic molecules, originally developed for the treatment of cancer but recently explored for the treatment of autoimmune and infectious diseases. Bordetella pertussis is a reemerging pathogen, and several of the key symptoms of infection are caused by the pertussis toxin (PTx). Two humanized antibodies, hu1B7 and hu11E6, bind distinct epitopes on PTx and, when coadministered, mitigate disease severity in murine and baboon models of infection. Here we describe the generation of a bispecific human IgG1 molecule combining the hu1B7 and hu11E6 binding sites via a knobs-in-holes design...
November 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27459964/goodpasture-s-syndrome-with-absence-of-circulating-anti-glomerular-basement-membrane-antibodies-a-case-report
#3
Rui Fernandes, Sara Freitas, Pedro Cunha, Gloria Alves, Jorge Cotter
BACKGROUND: Goodpasture's syndrome, a rare disease, is an organ-specific autoimmune disease mediated by anti-glomerular basement membrane antibodies. Its pathology is characterized by crescentic glomerulonephritis with linear immunofluorescent staining for immunoglobulin G on the glomerular basement membrane. Although rare, a few cases with absence of circulating anti-glomerular membrane antibodies have been described. CASE PRESENTATION: The objective of this clinical case report is to describe and discuss a case of a 27-year-old white man who was hospitalized with a 1-year history of weight loss and a 1-month history of hemoptysis, with aggravation  the day before, having developed dyspnea and cough in the previous 24 hours...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27352260/paraneoplastic-pemphigus-as-a-presentation-of-acute-myeloid-leukemia-early-diagnosis-and-remission
#4
Salahuddin Siddiqui, Mohammad Bilal, Zachary Otaibi, Farshaad Bilimoria, Nihar Patel, James Rossetti
Skin lesions are frequently encountered in clinical practice which can be a presentation of systemic diseases not excluding an occult malignancy. Commonly reported paraneoplastic dermatologic manifestations include acanthosis nigricans, dermatomyositis, erythroderma, hypertrophic osteoarthropathy, Sweet syndrome, and paraneoplastic pemphigus (PNP). PNP is a rare autoimmune mucocutaneous disease characterized by severe stomatitis, polymorphic skin eruptions, and associated underlying neoplasms most commonly non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and Castleman disease...
June 23, 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27000538/bartonella-henselae-infection-presenting-with-a-picture-of-adult-onset-still-s-disease
#5
Areum Durey, Hea Yoon Kwon, Jae-Hyoung Im, Sun Myoung Lee, JiHyeon Baek, Seung Baik Han, Jae-Seung Kang, Jin-Soo Lee
We report a patient with a clinical picture of suggestive for adult-onset Still's Disease (ASOD) due to Bartonella infection. A 42-year-old immunocompetent man was admitted with fever, rash, arthralgia and sore throat. As his clinical picture suggested ASOD except unusual skin manifestation, we treated him on steroid and ibuprofen. His fever and constitutional symptoms responded immediately within 24hrs of commencing therapy, yet rash and leukocytosis remained. Meanwhile, Bartonella infection was proved by culture of bone marrow...
May 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/26793930/hodgkin-s-lymphoma-presenting-as-a-cavitary-lung-lesion
#6
Joseph Garrity, Anna Batterson, Tamera Sturm
Hodgkin lymphoma (HL) typically presents in the nodal regions at an early stage of the disease. Occasionally, patients can present with disease in extranodal regions. We report a case of HL in a 25-year-old female who presented to the emergency department following a motor vehicle accident with incidental findings of pulmonary cavitary lesions, fever, tachycardia, anemia, leukocytosis and thrombocytosis. This case illustrates the difficulty in diagnosis when the disease presents in extranodal regions with nonspecific systemic symptoms...
December 2015: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/26356690/acute-splenic-infarction-at-an-academic-general-hospital-over-10-years-presentation-etiology-and-outcome
#7
Ami Schattner, Schattner Ami, Meital Adi, Adi Meital, Ella Kitroser, Kitroser Ella, Abraham Klepfish, Klepfish Abraham
Few case series provide a current, comprehensive, and detailed description of splenic infarction (SI), an uncommon condition.Retrospective chart review complemented by imaging evaluation and patient follow-up.All adult patients with a confirmed diagnosis of acute SI discharged over 10 years from a single academic center were studied. A systematic literature review was done to compile a complete list of SI etiologies.SI was found in 32 patients, 0.016% of admissions. Ages ranged from 18 to 86 (median 64) years...
September 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26317390/neutrophilic-epitheliotropism-is-a-histopathological-clue-to-neutrophilic-urticarial-dermatosis
#8
Sigrid M C Broekaert, Almut Böer-Auer, Katrin Kerl, Ilka Herrgott, Xenia Schulz, Gisela Bonsmann, Randolf Brehler, Dieter Metze
BACKGROUND: Neutrophilic urticarial dermatosis (NUD) comprises a particular autoinflammatory condition within the spectrum of aseptic neutrophilic dermatoses characterized by a distinct urticarial eruption clinically and a neutrophilic dermatosis histopathologically. OBJECTIVE: In this study, we reviewed skin biopsies of lesional skin of patients seen in our outpatient clinic for autoimmune dermatoses and in allergy department from 1982 to 2014 that fulfilled these criteria...
January 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26155624/-hemophagocytic-syndrome-in-a-patient-with-adult-onset-still-s-disease-diagnostic-problems
#9
A Yu Zakharova, Z Yu Mutovina, A V Gordeev, I N Shestakova
Hemophagocytic syndrome (HPS) is a rare life-threatening condition caused by massive cytokine release from activated macrophages and lymphocytes. The paper depicts the development of HPS in different infections, malignancies, and autoimmune diseases. It describes a clinical case of hemophagocytic syndrome in a 63-year-old female patient with adult-onset Still's disease and high fever accompanied by neutrophil leukocytosis and a drastic left leukocyte count shift, high procalcitonin levels, hepatosplenomegaly, edematous syndrome, and progressive multiple organ dysfunction with the development of disseminated intravascular coagulation and adult respiratory distress syndrome...
2015: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/25929927/the-pathologic-findings-of-skin-lymph-node-liver-and-bone-marrow-in-patients-with-adult-onset-still-disease-a-comprehensive-analysis-of-40-cases
#10
Hyoun-Ah Kim, Jee Eun Kwon, Hyunee Yim, Chang-Hee Suh, Ju-Yang Jung, Jae Ho Han
Adult-onset Still disease (AOSD) is characterized by fever, skin rash, and lymphadenopathy with leukocytosis and anemia as common laboratory findings. We investigated the characteristic pathologic findings of skin, lymph node, liver, and bone marrow to assist in proper diagnosis of AOSD.Forty AOSD patients were included in the study. The skin (26 patients), lymph node (8 patients), liver (8 patients), or bone marrow biopsies (22 patients) between 1998 and 2013 were retrospectively analyzed. AOSD patients were diagnosed according to the Yamaguchi criteria after excluding common infections, hematological and autoimmune diseases...
May 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25817081/chronic-lupus-peritonitis-is-characterized-by-the-ascites-with-a-large-content-of-interleukin-6
#11
Ryu Watanabe, Hiroshi Fujii, Yukiko Kamogawa, Kyohei Nakamura, Tsuyoshi Shirai, Tomonori Ishii, Hideo Harigae
Systemic lupus erythematosus (SLE) is an autoimmune disease and can cause multi-organ damage. Peritoneal involvement, also called lupus peritonitis, is a rare but sometimes fatal manifestation. Deposition of immune complexes consisting of immunoglobulin G and complement is considered to be involved in the pathogenesis of lupus peritonitis; however, it remains unknown whether inflammatory cytokines contribute to the pathology of this manifestation. Here we present two patients with treatment-resistant lupus peritonitis: a 37-year-old woman with a 26-year history of SLE who had been treated with prednisolone and cyclophosphamide followed by azathioprine and a 65-year-old woman with a 33-year history of SLE who had been treated with prednisolone alone...
2015: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/25691160/jmml-and-rald-ras-associated-autoimmune-leukoproliferative-disorder-common-genetic-etiology-yet-clinically-distinct-entities
#12
REVIEW
Katherine R Calvo, Susan Price, Raul C Braylan, Joao Bosco Oliveira, Michael Lenardo, Thomas A Fleisher, V Koneti Rao
Ras-associated autoimmune leukoproliferative disorder (RALD) is a chronic, nonmalignant condition that presents with persistent monocytosis and is often associated with leukocytosis, lymphoproliferation, and autoimmune phenomena. RALD has clinical and laboratory features that overlap with those of juvenile myelomonocytic leukemia (JMML) and chronic myelomonocytic leukemia (CMML), including identical somatic mutations in KRAS or NRAS genes noted in peripheral blood mononuclear cells. Long-term follow-up of these patients suggests that RALD has an indolent clinical course whereas JMML is fatal if left untreated...
April 30, 2015: Blood
https://www.readbyqxmd.com/read/25669035/-difference-in-measurements-of-erythrocyte-sedimentation-rate-obtained-using-two-devices-of-the-same-model-in-a-patient-with-marked-leukocytosis
#13
Takahiro Nojiri, Akiko Masuda, Ryunosuke Ohkawa, Kiyoko Koido, Hironori Shimosaka, Shigeo Okubo, Hiromitsu Yokota, Makoto Kurano, Yasuhito Nannya, Hitoshi Ikeda, Mineo Kurokawa, Yutaka Yatomi
The erythrocyte sedimentation rate (ESR) has been used as an index for inflammatory conditions, such as infectious diseases, autoimmune diseases, and malignancies. The ESR values of a 37-year-old male with marked leukocytosis due to chronic myeloid leukemia showed remarkable differences between two devices of the same model (Ves-Matic 30, DIESSE Diagnostica Senese). From the appearance of the tested tube after the ESR measurement, the values obtained using one device might have been falsely low, whereas the values obtained using the other device were likely to have been accurate...
July 2014: Rinsho Byori. the Japanese Journal of Clinical Pathology
https://www.readbyqxmd.com/read/25026804/-differential-diagnosis-of-rheumatic-diseases-and-blood-cancers-involving-the-nasal-cavity-and-accessory-sinuses
#14
V I Vasil'ev, E V Sokol, S Kh Sedyshev, V R Gorodetskiĭ, E N Aleksandrova, O A Logvinenko, S G Pal'shina, E B Rodionova, S G Radenska-Lopovok, N A Probatova, N V Kokosadze, A I Pavlovskaia, A M Kovrigina, E Iu Varlamova, T N Safonova, A B Borovskaia, I V Gaĭduk, O V Mukhortova, I P Aslanidi, E L Nasonov
AIM: To provide the clinical, laboratory, radiological, morphological, and immunomorphological signs that permit the differential diagnosis to be made in patients with involvement of the nasal cavity and accessory sinuses (NCAS). SUBJECTS AND METHODS: In the period 2009 to 2013, the Laboratory for Intensive Therapy for Rheumatic Diseases, V.A. Nasonova Research Institute of Rheumatology, Russian Academy of Medical Sciences, associated the disease onset with NCAS involvement in 39 (7...
2014: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/24898998/adult-onset-still-s-disease-presenting-as-myopericarditis
#15
Filipe André Gonzalez, Pedro Beirão, Joana Adrião, Margarida Lopes Coelho
A 24-year-old man presented to the emergency department with fever, maculopapular rash, myalgia and polyarthralgia, thoracic pain and dry cough, which had been present for 24 h. At the time of observation he had high fever (39°C), maculopapular rash on the torso, arms and legs proximally, axillary adenopathies and pharyngitis. Laboratorial data showed elevated inflammation markers (leukocytosis, C reactive protein of 44 mg/dL, erythrocyte sedimentation rate of 120 mm), elevated transaminases, lactate dehydrogenase, ferritin levels (>2000 ng/mL) and rising troponin...
2014: BMJ Case Reports
https://www.readbyqxmd.com/read/24872711/two-thymus-related-autoimmune-disorders-a-case-report-and-review-of-the-literature
#16
Hanifeh Mirtavoos-Mahyari, Adnan Khosravi, Zahra Esfahani-Monfared, Mohammad Behgam Shadmehr
Thymoma is the most common tumor in the anterior mediastinum. A 56-year-old man presented unremitting and periodic chronic diarrhea of 9 weeks duration, and clinical examination revealed a huge nonhomogeneous mass lesion in the right lung and leukocytosis. He was treated with CHOP regimen (cyclophosphamide 1,200 mg/m(2), doxorubicin 50 mg/m(2), vincristine 1.5 mg/m(2), and prednisolone 75 mg/m(2) × 5 days) based on lung mass computed tomography-guided biopsy, but he was reevaluated because neither symptom improved...
2014: OncoTargets and Therapy
https://www.readbyqxmd.com/read/24647019/infections-with-the-tick-borne-bacterium-candidatus-neoehrlichia-mikurensis-mimic-noninfectious-conditions-in-patients-with-b-cell-malignancies-or-autoimmune-diseases
#17
Anna Grankvist, Per-Ola Andersson, Mattias Mattsson, Monica Sender, Krista Vaht, Linnea Höper, Egidija Sakiniene, Estelle Trysberg, Martin Stenson, Jan Fehr, Sona Pekova, Christian Bogdan, Guido Bloemberg, Christine Wennerås
BACKGROUND: Candidatus Neoehrlichia mikurensis is a newly discovered noncultivatable bacterium spread among ticks and rodents in Europe and Asia that can infect humans, particularly immunocompromised patients. METHODS: We compiled clinical and laboratory data from 11 patients with hematological malignances or autoimmune diseases who were diagnosed with Candidatus N. mikurensis infection in Europe 2010-2013. Both published (6) and unpublished cases (5) were included...
June 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/24625491/-chronic-myeloid-leukemia-in-an-adult-with-common-variable-immunodeficiency
#18
Patricia María O'Farrill-Romanillos, Lucy Vania Galindo-Pacheco, Adela Sisy Amaya-Mejía, Freya Helena Campos-Romero, Laura Dafne Mendoza-Reyna, Fernando Pérez-Rocha, Nora Hilda Segura-Méndez
BACKGROUND: Common variable immunodeficiency is a primary immunodeficiency, in which from 70 to 80 % of patients have tumors and 25 % of cases are associated with autoimmune diseases. Common variable immunodeficiency patients have a higher incidence of neoplasms, with a risk 12-18 times higher than the general population. There are few cases of common variable immunodeficiency patients with leukemia. CLINICAL CASE: Female of 36 years old, with left upper quadrant pain, early satiety, weight loss of 8 kg in three months and splenomegaly...
January 2014: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/24435354/life-threatening-complications-of-adult-onset-still-s-disease
#19
REVIEW
Petros Efthimiou, Sabeeda Kadavath, Bella Mehta
Adult-onset Still's Disease (AOSD) since its description in 1971 has proven to be a very complex and challenging disease entity. This rare auto-inflammatory disease is classically described by the "Still's triad" of fever, rash, and arthritis, although the atypical cases frequently outnumber the typical ones. The exact pathogenesis and etiologic factors responsible for the clinical features remain largely obscure, despite recent suggestive cytokine biology findings. Diagnosis is made on clinical grounds, following the exclusion of mimickers of infectious, autoimmune or neoplastic etiology, with the additional consideration of non-specific laboratory abnormalities such as peripheral leukocytosis and elevation of serum ferritin and other acute phase reactants...
March 2014: Clinical Rheumatology
https://www.readbyqxmd.com/read/24379662/intradermal-air-pouch-leukocytosis-as-an-in-vivo-test-for-nanoparticles
#20
Jennifer Vandooren, Nele Berghmans, Chris Dillen, Ilse Van Aelst, Isabelle Ronsse, Liron Limor Israel, Ina Rosenberger, Jörg Kreuter, Jean-Paul Lellouche, Shulamit Michaeli, Erica Locatelli, Mauro Comes Franchini, Miren K Aiertza, Laura Sánchez-Abella, Iraida Loinaz, Dylan R Edwards, Louis Shenkman, Ghislain Opdenakker
The need for test systems for nanoparticle biocompatibility, toxicity, and inflammatory or adaptive immunological responses is paramount. Nanoparticles should be free of microbiological and chemical contaminants, and devoid of toxicity. Nevertheless, in the absence of contamination, these particles may still induce undesired immunological effects in vivo, such as enhanced autoimmunity, hypersensitivity reactions, and fibrosis. Here we show that artificial particles of specific sizes affect immune cell recruitment as tested in a dermal air pouch model in mice...
2013: International Journal of Nanomedicine
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