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https://www.readbyqxmd.com/read/28635608/the-protective-role-of-folic-acid-against-testicular-dysfunction-in-lead-intoxicated-rat-model
#1
Asmaa Ms Gomaa, Nasser S Abou Khalil, Mohammed A Abdel-Ghani
There is an increasing concern over male reproductive toxicity caused by lead exposure. Folic acid (FA) is supposed to be a promising therapeutic strategy against lead toxicity. Therefore, the aim of this experimental study was to shed light on the potential protective role of FA on lead-induced testicular dysfunction in rats and its possible underlying mechanistic pathways. Rats (n = 24) were divided into four groups: Control, FA, Lead, and FA+Lead group. After 4 weeks, lead intoxication resulted in a marked reduction in the relative testicular weight and the serum level of testosterone, an impairment in the characters of semen analysis, and an increased content of lead, malondialdehyde and both interleukin-6 and -10 and a decreased antioxidant enzyme levels in the testicular tissue homogenate...
July 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/28633813/multi-stimuli-responsive-smart-chitosan-based-microcapsules-for-targeted-drug-delivery-and-triggered-drug-release
#2
Xuejun Cui, Xinyu Guan, Shuangling Zhong, Jie Chen, Houjuan Zhu, Zhanfeng Li, Fengzhi Xu, Peng Chen, Hongyan Wang
In the present study, we designed a novel, multi-stimuli responsive, biocompatible and non-immunogenic smart carrier for targeted delivery and triggered release of hydrophobic drugs. The designed multi-stimuli responsive smart chitosan-based microcapsules (MSRS-CS-MCs) have been fabricated successfully from folic acid (FA) functionalized thiolated chitosan via a facile sonochemical method. Targeting moiety FA and red fluorescent dye (Rhodamine B isothiocyanate, RITC) were immobilized onto the shells of microcapsules...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28632263/fabrication-of-a-graphene-c60-nanohybrid-via-%C3%AE-cyclodextrin-host-guest-chemistry-for-photodynamic-and-photothermal-therapy
#3
Zhen Hu, Cheng Wang, Feng Zhao, Xirong Xu, Shuhong Wang, Long Yu, Dayu Zhang, Yudong Huang
The wonderful chemical structures and characteristics of low-dimensional carbon materials have exciting applications in life sciences. In the present study, we developed a facile strategy to conjugate C60 with graphene via host-guest chemistry for targeted phototherapy. A versatile carrier based on folic acid-functionalized graphene (GO-FA) and comprising γ-cyclodextrin (γ-CD) at its surface was assembled via π-π interaction, creating hybrid structures with drug storage and tumor targeting properties. This γ-CD-modified graphene (GO-FA/Py-γ-CD) is capable of hosting pristine C60 molecules for the fabrication of a GO-FA/Py-γ-CD/C60 nanohybrid...
June 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28631291/folate-deficiency-disturbs-hsa-let-7-g-level-through-methylation-regulation-in-neural-tube-defects
#4
Li Wang, Shaofang Shangguan, Yu Xin, Shaoyan Chang, Zhen Wang, Xiaolin Lu, Lihua Wu, Bo Niu, Ting Zhang
Folic acid deficiency during pregnancy is believed to be a high-risk factor for neural tube defects (NTDs). Disturbed epigenetic modifications, including miRNA regulation, have been linked to the pathogenesis of NTDs in those with folate deficiency. However, the mechanism by which folic acid-regulated miRNA influences this pathogenesis remains unclear. It is believed that DNA methylation is associated with dysregulated miRNA expression. To clarify this issue, here we measured the methylation changes of 22 miRNAs in 57 human NTD cases to explore whether such changes are involved in miRNA regulation in NTD cases through folate metabolism...
June 19, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28628360/genetic-risk-factors-for-folate-responsive-neural-tube-defects
#5
Anne M Molloy, Faith Pangilinan, Lawrence C Brody
Neural tube defects (NTDs) are the most severe congenital malformations of the central nervous system. The etiology is complex, with both genetic and environmental factors having important contributions. Researchers have known for the past two decades that maternal periconceptional use of the B vitamin folic acid can prevent many NTDs. Though this finding is arguably one of the most important recent discoveries in birth defect research, the mechanism by which folic acid exerts this benefit remains unknown. Research to date has focused on the hypothesis that an underlying genetic susceptibility interacts with folate-sensitive metabolic processes at the time of neural tube closure...
June 19, 2017: Annual Review of Nutrition
https://www.readbyqxmd.com/read/28627503/three-layered-polyplex-as-a-microrna-targeted-delivery-system-for-breast-cancer-gene-therapy
#6
Yan Li, Yu Dai, Xiaojin Zhang, Jihua Chen
MicroRNAs (miRNAs), small non-coding RNAs, play an important role in modulating cell proliferation, migration, and differentiation. Since miRNAs can regulate multiple cancer-related genes simultaneously, regulating miRNAs could target a set of related oncogenic genes or pathways. Owing to their reduced immune response and low toxicity, miRNAs with small size and low molecular weight have become increasingly promising therapeutic drugs in cancer therapy. However, one of the major challenges of miRNAs-based cancer therapy is to achieve specific, effective, and safe delivery of therapeutic miRNAs into cancer cells...
June 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28624453/folic-acid-attenuates-cobalt-chloride-induced-pge2-production-in-huvecs-via-the-no-hif-1alpha-cox-2-pathway
#7
Yuming Liang, Xiaozhou Zhen, Kaiwen Wang, Jing Ma
Prostaglandin E2 (PGE2), an important lipid inflammatory mediator involved in the progression of vascular diseases, can be induced by hypoxia in many cell types. While folic acid has been shown to protect against inflammation in THP-1 cells duringpo hypoxia and hypoxia-induced endothelial cell injury, whether it might do so by attenuating PGE2 production remains unclear. To investigate this we constructed a hypoxia-induced injury model by treating human umbilical vein endothelial cells (HUVECs) with cobalt chloride (CoCl2), which mimics the effects of hypoxia...
June 14, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28623904/impact-of-preconceptional-micronutrient-supplementation-on-maternal-mental-health-during-pregnancy-and-postpartum-results-from-a-randomized-controlled-trial-in-vietnam
#8
Phuong H Nguyen, Ann M DiGirolamo, Ines Gonzalez-Casanova, Hoa Pham, Wei Hao, Hieu Nguyen, Truong V Truong, Son Nguyen, Kimberly B Harding, Gregory A Reinhart, Reynaldo Martorell, Usha Ramakrishnan
BACKGROUND: Micronutrient malnutrition has been associated with maternal depressive symptoms (MDS), but little is known about the effects of preconceptional micronutrient supplementation. This paper examined the effects of preconceptional micronutrient supplementation on MDS during pregnancy and postpartum. METHODS: We used data from a double-blind controlled trial (PRECONCEPT) in which 5011 Vietnamese women were randomized to receive weekly supplements containing either a) multiple micronutrients (MM) b) iron and folic acid (IFA) or c) folic acid (FA) until conception (n = 1813)...
June 17, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28620818/effects-of-atorvastatin-and-simvastatin-on-oxidative-stress-in-diet-induced-hyperhomocysteinemia-in-wistar-albino-rats-a-comparative-study
#9
T Nikolic, V Zivkovic, I Srejovic, I Stojic, N Jeremic, J Jeremic, K Radonjic, S Stankovic, R Obrenovic, D Djuric, V Jakovljevic
Considering the well-known antioxidant properties of statins, it seems important to assess their impact on major markers of oxidative stress (superoxide anion radical, nitric oxide, and index of lipid peroxidation) to compare the antioxidative potentials of atorvastatin and simvastatin during the different degrees of hyperhomocysteinemia (HHcy) in rats. This study was conducted on adult male Wistar albino rats (n = 90; 4 weeks old; 100 ± 15 g body mass) in which HHcy was achieved by dietary manipulation...
June 15, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28617530/effects-of-folic-acid-combined-with-vitamin-b12-on-dvt-in-patients-with-homocysteine-cerebral-infarction
#10
X-J Shu, Z-F Li, Y-W Chang, S-Y Liu, W-H Wang
OBJECTIVE: To investigate the effects of folic acid combined with vitamin B12 on deep vein thrombosis (DVT) in patients with homocysteine cerebral infarction. PATIENTS AND METHODS: 90 patients with homocysteine cerebral infarction with DVT that were admitted to our hospital from January to July 2015 were selected as study subjects. They were divided into 2 groups randomly, the treatment group (n=45) and the non-treatment group (n=45). The treatment group was administered folic acid and vitamin B12, while the non-treatment group wasn't administered folic acid and vitamin B12...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617257/do-italian-pregnant-women-use-periconceptional-folate-supplementation
#11
Alice Maraschini, Paola D'Aloja, Ilaria Lega, Marta Buoncristiano, Ursula Kirchmayer, Martina Ventura, Serena Donati
INTRODUCTION: Deficiency of folic acid (FA) has been identified as a risk factor for neural tube defects (NTDs) as well as other congenital anomalies. Thus, periconceptional folate supplementation is recommended for all women planning to get pregnant. METHODS: We conducted a KAP (knowledge, attitude, practice) survey to investigate the use of FA and its appropriateness. The survey included a sample of 562 women who delivered in the Lazio region between 2013 and 2014...
April 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28616960/functional-build-in-template-directed-siliceous-fluorescent-supramolecular-vesicles-as-diagnostics
#12
Jie Li, Kaerdun Liu, Hengyu Chen, Ruoyan Li, Markus Drechsler, Fan Bai, Jianbin Huang, Ben Zhong Tang, Yun Yan
Functional template directed synthesis of hybrid siliceous fluorescent vesicle (HSFV) is fabricated by using fluorescent vesicle as a build-in template. The template vesicle is the ionic self-assembly of an aggregation-induced emission (AIE) fluorogen. Upon depositing folic acid modified silica shell on its surface, the obtained HSFVs display low cytotoxicity, significant fluorescence and targeted drug delivery toward cancer cells. Furthermore, the wall-thickness of the HSFVs can be controlled via altered concentration of silica source...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28615379/daily-consumption-of-lipid-based-nutrient-supplements-containing-250-%C3%AE-g-iodine-does-not-increase-urinary-iodine-concentrations-in-pregnant-and-postpartum-women-in-bangladesh
#13
Malay K Mridha, Susana L Matias, Rina Rani Paul, Sohrab Hussain, Md Showkat Ali Khan, Zakia Siddiqui, Barkat Ullah, Mostofa Sarker, Mokbul Hossain, Rebecca T Young, Charles D Arnold, Kathryn G Dewey
Background: Maternal iodine deficiency during pregnancy and lactation is common in Bangladesh.Objective: We evaluated the effect of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on urinary iodine concentration (UIC).Methods: We conducted a cluster-randomized controlled effectiveness trial in which we enrolled 4011 pregnant women at ≤20 gestational weeks. Women in 48 clusters received iron and folic acid (IFA; 60 mg Fe/d + 400 μg folic acid/d) and women in 16 clusters received LNS-PL (20 g/d, 118 kcal) containing 22 vitamins and minerals (including 250 μg I)...
June 14, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28615372/preconception-micronutrient-supplementation-with-iron-and-folic-acid-compared-with-folic-acid-alone-affects-linear-growth-and-fine-motor-development-at-2-years-of-age-a-randomized-controlled-trial-in-vietnam
#14
Phuong H Nguyen, Ines Gonzalez-Casanova, Melissa F Young, Truong Viet Truong, Hue Hoang, Huong Nguyen, Son Nguyen, Ann M DiGirolamo, Reynaldo Martorell, Usha Ramakrishnan
Background: Maternal health and nutrition play a crucial role in early child growth and development. However, little is known about the benefits of preconception micronutrient interventions beyond the role of folic acid (FA) and neural tube defects.Objective: We evaluated the impact of weekly preconception multiple micronutrient (MM) or iron and folic acid (IFA) supplementation on child growth and development through the age of 2 y compared with FA alone.Methods: We followed 1599 offspring born to women who participated in a randomized controlled trial of preconception supplementation in Vietnam...
June 14, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28615265/adequacy-of-nutritional-intake-from-food-and-supplements-in-a-cohort-of-pregnant-women-in-qu%C3%A3-bec-canada-the-3d-cohort-study-design-develop-discover
#15
Lise Dubois, Maikol Diasparra, Brigitte Bédard, Cynthia K Colapinto, Bénédicte Fontaine-Bisson, Anne-Sophie Morisset, Richard E Tremblay, William D Fraser
Background: Assessments of the dietary intakes in various populations suggest that pregnant women have difficulty meeting all their nutritional requirements through diet alone. Few large-scale studies have considered both food sources and supplements in assessing the adequacy of nutritional intakes during pregnancy.Objectives: Our study aimed to assess nutritional intakes during pregnancy by examining dietary sources and supplements. It then compared these findings with Dietary Reference Intakes.Design: We conducted a nutrition study in a large pregnancy cohort using a 3-d food record during the second trimester of pregnancy...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28608983/folic-acid-reduces-doxorubicin-induced-cardiomyopathy-by-modulating-endothelial-nitric-oxide-synthase
#16
Yanti Octavia, Georgios Kararigas, Martine de Boer, Ihsan Chrifi, Rinrada Kietadisorn, Melissa Swinnen, Hans Duimel, Fons K Verheyen, Maarten M Brandt, Daniela Fliegner, Caroline Cheng, Stefan Janssens, Dirk J Duncker, An L Moens
The use of doxorubicin (DOXO) as a chemotherapeutic drug has been hampered by cardiotoxicity leading to cardiomyopathy and heart failure. Folic acid (FA) is a modulator of endothelial nitric oxide (NO) synthase (eNOS), which in turn is an important player in diseases associated with NO insufficiency or NOS dysregulation, such as pressure overload and myocardial infarction. However, the role of FA in DOXO-induced cardiomyopathy is poorly understood. The aim of this study was to test the hypothesis that FA prevents DOXO-induced cardiomyopathy by modulating eNOS and mitochondrial structure and function...
June 13, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28608898/five-nanometer-znsn2o4-cr-eu-ultra-small-nanoparticles-as-new-near-infrared-emitting-persistent-luminescent-nanoprobes-for-cellular-and-deep-tissue-imaging-at-800-nm
#17
Jin-Lei Li, Jun-Peng Shi, Cheng-Cheng Wang, Peng-Hui Li, Zhen-Feng Yu, Hong-Wu Zhang
Until now, the afterglow emissions of most developed near infrared (NIR)-emitting persistent luminescent nanoparticles (NPLNPs) were located at approximately 700 nm, at the edge of the first tissue transparency window (from 650 to 900 nm), which resulted in relatively low tissue penetration and signal-to-noise ratio (SNR) for in vivo imaging. Herein, 5 nm ZnSn2O4:Cr,Eu (ZSO) NPLNPs with NIR afterglow emission at 800 nm are synthesized via a direct aqueous-phase synthesis method. The longer NIR afterglow emission of ZSO NPLNPs can easily penetrate approximately 3 cm of pork tissue...
June 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28608677/block-copolymer-based-nanoparticles-for-theranostic-intervention-of-cervical-cancer-synthesis-pharmacokinetics-and-in-vitro-in-vivo-evaluation-in-hela-xenograft-models
#18
Shweta Dumoga, Yogesh Rai, Anant Narayan Bhatt, Anjani Kumar Tiwari, Surendra Singh, Anil Kumar Mishra, Dipti Kakkar
Polymer based nanoparticles have proven to be viable carriers of therapeutic agents. In this study we have developed nanoparticles (NPs) from polypeptide-polyethylene glycol based triblock and diblock copolymers. The synthesized block copolymers Poly (ethylene glycol)-b-Poly (glutamic acid)-b- Poly (ethylene glycol) (GEG) and Poly (ethylene glycol)-b-Poly (glutamic acid) (EG) conjugated with folic acid for targeting specificity (EGFA), have been used to encapsulate methotrexate (MTX) to form M-GEG and M-EGFA nanoparticles (NPs) aimed at passive and active targeting of cervical carcinoma...
June 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28607125/effects-of-folic-acid-therapy-on-the-new-onset-proteinuria-in-chinese-hypertensive-patients-a-post-hoc-analysis-of-the-renal-substudy-of-csppt-china-stroke-primary-prevention-trial
#19
Youbao Li, Min Liang, Guobao Wang, Binyan Wang, Mingli He, Genfu Tang, Delu Yin, Xin Xu, Yong Huo, Yimin Cui, Fan Fan Hou, Xianhui Qin
We aimed to test the hypothesis that treatment with enalapril and folic acid is more effective in preventing new-onset proteinuria than enalapril alone among hypertensive patients. This is a post hoc analysis of the renal substudy of the CSPPT (China Stroke Primary Prevention Trial). A total of 13 071 eligible participants without proteinuria were randomized to receive a double-blind daily treatment of a single tablet containing 10-mg enalapril and 0.8-mg folic acid (n=6511) or 10-mg enalapril alone (n=6560)...
June 12, 2017: Hypertension
https://www.readbyqxmd.com/read/28606519/folate-conjugated-thermosensitive-o-maleoyl-modified-chitosan-micellar-nanoparticles-for-targeted-delivery-of-erlotinib
#20
Marziyeh Fathi, Parham Sahandi Zangabad, Ayuob Aghanejad, Jaleh Barar, Hamid Erfan-Niya, Yadollah Omidi
In the present work, new self-assembled nanoparticles (NPs) were engineered using biocompatible and biodegradable natural polymer, chitosan (CS). The complexation of CS with sodium dodecyl sulfate (SDS) facilitated the regioselective chemical modification of CS hydroxyl groups with maleic anhydride, and produced polymerizable precursor of CS that was further grafted with N-isopropylacrylamide (NIPAAm) as temperature-sensitive moiety and oleic acid (OA) as hydrophobic monomer. After removal of SDS complex, the free amino groups were functionalized with folic acid (FA) to form folate-(PNIPAAm-co-OA)-g-CS micellar NPs...
September 15, 2017: Carbohydrate Polymers
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