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https://www.readbyqxmd.com/read/28208817/validity-of-the-food-frequency-questionnaire-assessing-the-folate-intake-in-women-of-reproductive-age-living-in-a-country-without-food-fortification-application-of-the-method-of-triads
#1
Milica Zekovic, Marija Djekic-Ivankovic, Marina Nikolic, Mirjana Gurinovic, Dusanka Krajnovic, Marija Glibetic
The study aimed to examine the external validity of the Folate Food Frequency Questionnaire (F-FFQ) designed for assessing the folate intake in Serbian women of reproductive age. The F-FFQ was tested against repeated 24 h dietary recalls and correspondent nutritional biomarkers (red blood cells (RBC) and serum folate concentrations) using the method of triads. In a cross sectional study, 503 women aged 18-49 years completed dietary questionnaires and representative validation subsample (n = 50) provided fasting blood samples for biomarker analyses...
February 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28208798/maternal%C3%A2-folic%C3%A2-acid%C3%A2-supplementation%C3%A2-during%C3%A2-pregnancy%C3%A2-and%C3%A2-childhood%C3%A2-allergic%C3%A2-disease%C3%A2-outcomes-%C3%A2-a%C3%A2-question%C3%A2-of%C3%A2-timing
#2
REVIEW
Catrina L McStay, Susan L Prescott, Carol Bower, Debra J Palmer
Since the early 1990s, maternal folic acid supplementation has been recommended prior  to and during the first trimester of pregnancy, to reduce the risk of infant neural tube defects. In  addition, many countries have also implemented the folic acid fortification of staple foods, in order  to promote sufficient intakes amongst women of a childbearing age, based on concerns surrounding  variable dietary and supplementation practices. As many women continue to take folic acid  supplements beyond the recommended first trimester, there has been an overall increase in folate  intakes, particularly in countries with mandatory fortification...
February 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28194631/development-of-a-new-folate-derived-ga-68-based-pet-imaging-agent
#3
Christian Brand, Valerie A Longo, Mike Groaning, Wolfgang A Weber, Thomas Reiner
PURPOSE: The folate receptor (FR) has emerged as an interesting diagnostic and therapeutic drug target with many potential applications in oncologic and inflammatory disorders. It was therefore the aim of this study to develop a folate-derived Ga-68-based positron emission tomography (PET) imaging tracer that is straightforward to radiolabel and could be broadly used in clinical studies. We validated its target binding affinity and specificity and compared it to [(99m)Tc]EC20, the folate single-photon emission computed tomography (SPECT) imaging tracer that has been most extensively studied clinically so far...
February 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28193559/dual-functional-mesoporous-silicon-nanoparticles-enhance-the-radiosensitivity-of-vpa-in-glioblastoma
#4
Hailong Zhang, Wei Zhang, Yong Zhou, Yuhua Jiang, Shupeng Li
Radiotherapy is a critical strategy and standard adjuvant approach to glioblastoma treatment. One of the major challenges facing radiotherapy is to minimize radiation damage to normal tissue without compromising therapeutic effects on cancer cells. Various agents and numerous approaches have been developed to improve the therapeutic index of radiotherapy. Among them, radiosensitizers have attracted much attention because they selectively increase susceptibility of cancer cells to radiation and thus enhance biological effectiveness of radiotherapy...
February 10, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28192920/diagnosis-therapy-integrative-systems-based-on-magnetic-rna-nanoflowers-for-co-drug-delivery-and-targeted-therapy
#5
Yingshu Guo, Shuang Li, Yujie Wang, Shusheng Zhang
This study was to develop a codrug delivery system for targeting cancer therapy based on magnetic RNA nanoflowers (RNA NF). Compared with traditional nucleic acid structure, convenient separation can be achieved by introducing magnetic nanoparticle (MNP) into RNA NF. Folic acid (FA) modified MNP/RNA NF (FA/MNP/RNA NF) was used as a targeting nanocarrier with excellent biocompatibility to overcome the nonselectivity of MNP/RNA NF. And then, anticancer drug doxorubicin (DOX) and photosensitizer 5, 10, 15, 20-tetrakis (1-methylpyridinium-4-yl) porphyrin (TMPyP4) binding with RNA NF were used as codrug cargo models...
February 8, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28191959/mitoxantrone-and-folate-tpgs2k-conjugate-hybrid-micellar-aggregates-to-circumvent-toxicity-and-enhance-efficiency-for-breast-cancer-therapy
#6
Nida El Islem Guissi, Huipeng Li, Yurui Xu, Farouk Semcheddine, Minglei Chen, Zhigui Su, Qineng Ping
Mitoxantrone (MTO) is a potent drug used to treat breast cancer; however, efforts to expand its applicability have been limited by the risk of cardiotoxicity. In this study, we successfully conjugated MTO or folic acid (FA) to a synthesized d-α-tocopheryl polyethylene glycol 2000 succinate (TPGS2k), which were short for MCT or FCT. These two micellar materials could self-assemble to form MCT micelles or MCT/FCT mixed micelles (FMCT) aiming to lower systemic toxicity, enhance entrapment efficiency and provide a platform for targeting delivery...
February 13, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28191262/maternal-intake-of-methyl-group-donors-affects-dna-methylation-of-metabolic-genes-in-infants
#7
Sara Pauwels, Manosij Ghosh, Radu Corneliu Duca, Bram Bekaert, Kathleen Freson, Inge Huybrechts, Sabine A S Langie, Gudrun Koppen, Roland Devlieger, Lode Godderis
BACKGROUND: Maternal nutrition during pregnancy and infant nutrition in the early postnatal period (lactation) are critically involved in the development and health of the newborn infant. The Maternal Nutrition and Offspring's Epigenome (MANOE) study was set up to assess the effect of maternal methyl-group donor intake (choline, betaine, folate, methionine) on infant DNA methylation. Maternal intake of dietary methyl-group donors was assessed using a food-frequency questionnaire (FFQ)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28189110/amplified-electrochemical-sensor-employing-cuo-swcnts-and-1-butyl-3-methylimidazolium-hexafluorophosphate-for-selective-analysis-of-sulfisoxazole-in-the-presence-of-folic-acid
#8
Hassan Karimi-Maleh, Fatemeh Amini, Ahmad Akbari, Moein Shojaei
In the present work, CuO nanoparticle decorated on single wall carbon nanotubes (CuO/SWCNTs) nanocomposite was successfully synthesized by chemical precipitation method and used for modification of carbon paste electrode (CPE) in the presence of 1-butyl-3-methylimidazolium hexafluorophosphate (1-B-3-MIHFP) liquid as binder. The novel voltammetric sensor was used as first electrochemical sensor for determination of sulfisoxazole (SFX). CuO/SWCNTs nanocomposite characterized by scanning electron microscopy (SEM) and X-ray powder diffraction (XRD) methods...
February 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28188925/impact-of-genetic-polymorphisms-in-key-enzymes-of-homocysteine-metabolism-on-the-pathophysiology-of-sickle-cell-anemia
#9
Danilo Grünig Humberto da Silva, Edis Belini Junior, Lidiane de Souza Torres, Jessika Viviani Okumura, Willian Marcel Barberino, Renan Garcia de Oliveira, Vanessa Urbinatti Teixeira, Clarisse Lopes de Castro Lobo, Eduardo Alves de Almeida, Claudia Regina Bonini-Domingos
This work aimed at studying a possible influence of methylenetetrahydrofolate reductase (MTHFR; c. 677C>T) and cystathionine β-synthase (CBS; 844ins68) polymorphisms on overall oxidative status of sickle cell anemia (SCA) patients and on routine markers, correlating them with hydroxycarbamide (HC) treatment. We evaluated 95 unrelated and diagnosed SCA patients. All patients received a prophylactic treatment with folic acid of 5mg/day, while 41 (43.2%) of them were under hydroxycarbamide (HC) treatment (average dose: 22mg/kg/day)...
February 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28185404/consumption-of-dietary-supplements-by-chinese-women-during-pregnancy-and-postpartum-a-prospective-cohort-study
#10
Li Tang, Andy H Lee, Kelvin K W Yau, Yer Van Hui, Colin W Binns
The objectives of this study were to investigate usage patterns and factors associated with maternal dietary supplementation by Chinese women. A prospective cohort study of 695 mothers, who gave birth to a singleton baby, was conducted in Jiangyou, Sichuan Province of China. Information on dietary supplement use was collected from participants by personal interview at hospital discharge and followed up by telephone at 1, 3, and 6 months postpartum. Logistic regression analysis and generalised linear-mixed modelling were performed to determine factors affecting dietary supplementation during pregnancy and the first 6 months postpartum, respectively...
February 10, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28185308/medical-cost-savings-in-sakado-city-and-worldwide-achieved-by-preventing-disease-by-folic-acid-fortification
#11
REVIEW
Yasuo Kagawa, Mami Hiraoka, Mitsuyo Kageyama, Yoshiko Kontai, Mayumi Yurimoto, Chiharu Nishijima, Kaori Sakamoto
The introduction of mandatory fortification of grains with folate in 1998 in the United States resulted in 767 fewer spina bifida cases annually and a cost savings of $603 million per year. However, far more significant medical cost savings result from preventing common diseases, including myocardial infarction, stroke, dementia and osteoporosis. A cost-effectiveness analysis showed a gain of 266,649 quality-adjusted life-years and $3.6 billion saved annually, mainly due to the reduction of cardiac infarction...
February 9, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28185129/folic-acid-protects-against-glutamate-induced-excitotoxicity-in-hippocampal-slices-through-a-mechanism-that-implicates-inhibition-of-gsk-3%C3%AE-and-inos
#12
Josiane Budni, Simone Molz, Tharine Dal-Cim, Maria Dolores Martín-de-Saavedra, Javier Egea, Manuela G Lopéz, Carla Ines Tasca, Ana Lúcia Severo Rodrigues
Folic acid (folate) is a vitamin of the B-complex group crucial for neurological function. Considering that excitotoxicity and cell death induced by glutamate are involved in many disorders, the potential protective effect of folic acid on glutamate-induced cell damage in rat hippocampal slices and the possible intracellular signaling pathway involved in such effect were investigated. The treatment of hippocampal slices with folic acid (100 μM) significantly abrogated glutamate (1 mM)-induced reduction of cell viability measured by MTT reduction assay and inhibited glutamate-induced D-[(3)H]-aspartate release...
February 10, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28182848/simultaneous-determination-of-8-b-vitamins-in-rat-intestinal-perfusate-to-identify-effects-of-osmotic-pressures-on-absorptions
#13
Xiaobo Wang, Jian Xiao, Hui Zhou, Ying Qiu, Hui Peng, Yangyang Sun, Jiwen Zhang, Wei Qian, Lixin Sun
A rapid and accurate HPLC-DAD method was developed and validated to simultaneously determine eight B-vitamins (VBs, namely thiamine, riboflavin, niacinamide, calcium pantothenic, pyridoxine, biotin, folic acid, and cyanocobalamin) and phenolsulfonphthalein in rat intestinal perfusate. Chromatography separation was achieved using an Inertsil ODS-3 column (250 × 4.6 mm i.d., 5 µm) at the temperature of 40 °C. Gradient elution mode was applied at the flow rate of 1.0 mL/min with the mobile phase of acetonitrile-30 mM K2 HPO4 (pH 5...
February 9, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28182264/relative-risk-of-and-determinants-for-adverse-events-of-methotrexate-prescribed-at-a-low-dose-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#14
REVIEW
C Mazaud, L Fardet
Low-dose (i.e., ≤30 mg/week) methotrexate is widely prescribed by dermatologists. However, there are few evidence-based data regarding the relative risk of and determinants for adverse events associated with this treatment. The aims of this review were to assess the relative risk of and the determinants for adverse events associated with low-dose methotrexate exposure. A systematic review was undertaken using the MEDLINE, EMBASE, and CENTRAL databases. Randomized controlled trials comparing low-dose methotrexate with placebo were eligible...
February 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28174106/radiosynthesis-and-evaluation-of-a-99m-tc-folic-acid-radiotracer-prepared-using-99m-tcn-pnp-2-metal-fragment
#15
Kusum Vats, Suresh Subramanian, Anupam Mathur, Haladhar Dev Sarma, Sharmila Banerjee
Folate receptors (FR) are over-expressed on a wide variety of tumor cells and are a potential molecular target for radiolabeled folates. In this respect, several SPECT and PET based radiofolates have been evaluated in the past albeit with their high renal uptake posing limitation towards their clinical use. To overcome this, a new (99m)Tc labeled folic acid was synthesized via the use of [(99m)TcN(PNP)](2+) metal fragment, where the presence of the latter pharmacophore redirects in vivo clearance via the hepatobiliary pathway...
March 30, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28168180/association-between-nutrient-intake-and-metabolic-syndrome-in-patients-with-colorectal-cancer
#16
Hee-Sook Lim, Eung-Jin Shin, Jeong-Won Yeom, Yoon-Hyung Park, Soon-Kyung Kim
The purpose of this study was to investigate the difference of nutritional status according to metabolic syndrome in colorectal cancer patients. The subjects were divided into 2 groups (metabolic syndrome group and normal group) according to the presence or absence of metabolic syndrome in 143 patients diagnosed with colorectal cancer, and their lifestyle and nutritional status were analyzed. Recall method was used for the dietary survey, and metabolic syndrome was defined as the presence of 3 or more of waist circumference, fasting blood glucose, triglyceride, high-density lipoprotein (HDL)-cholesterol, and blood pressure...
January 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/28167509/results-from-a-phase-i-ii-open-label-dose-finding-study-of-pralatrexate-and-oral-bexarotene-in-patients-with-relapsed-refractory-cutaneous-t-cell-lymphoma
#17
Madeleine Duvic, Youn H Kim, Pier Luigi Zinzani, Steven Horwitz
PURPOSE: Pralatrexate is a folic acid analog metabolic inhibitor similar to methotrexate,that has shown tolerability and efficacy with an overall response rate of 45% in a phase 1 dose de-escalation study of patients with relapsed/refractory cutaneous T-cell lymphoma CTCL. EXPERIMENTAL DESIGN: The object of this phase I/II open-label, multi-center clinical trial was to determine the maximum tolerated dose (MTD) and recommended dose of pralatrexate plus oral bexarotene in 34 patients with relapsed/refractory CTCL who had failed prior systemic therapies...
February 6, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28167358/evaluation-of-pharmacists-knowledge-of-women-s-issues-in-epilepsy-a-cross-sectional-study-in-palestinian-pharmacy-practice
#18
Ramzi Shawahna, Ahlam Atrash, Aman Jebril, Areen Khalaf, Eman Shaheen, Hala Tahboosh
PURPOSE: Pharmacists are key players in providing healthcare for patients with chronic diseases including women with epilepsy. The purpose of this study was to assess pharmacist's knowledge of women's issues in epilepsy in the Palestinian pharmacy practice. METHOD: The study was conducted in a cross-sectional observational design using a 12-item test on women's health in epilepsy. Demographic details were collected. Scores were calculated as percentage of correct answers for each pharmacist...
January 19, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28166354/the-nephroprotective-effect-of-folic-acid-only-a-matter-of-homocysteine-reply
#19
Fan Fan Hou, Xin Xu
No abstract text is available yet for this article.
February 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28166345/the-nephroprotective-effect-of-folic-acid-only-a-matter-of-homocysteine
#20
Sebastian Cabrera, Miram Alvo, Charles Ferro
No abstract text is available yet for this article.
February 1, 2017: JAMA Internal Medicine
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