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https://www.readbyqxmd.com/read/28542653/-folate-and-pregnancy-current-concepts-it-is-required-folic-acid-supplementation
#1
Erika Castaño, Raúl Piñuñuri, Sandra Hirsch, Ana María Ronco
Folate intake during pregnancy is essential for an adequate fetal and placental development and for the long time health of the individual. Its deficiency may induce fetal pathologies, including neural tube disease (NTD). Therefore, several countries implemented public policies to fortify foods with folic acid (FA). Chile started the fortification of wheat flour with FA in the year 2000, decreasing a 43% the prevalence of NTD. However, despite the high consumption of bread (the main fortified food with FA) by our population, a high number of pregnant women consume FA supplements, thus, over passing the maximal recommended FA intake...
April 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28542318/predicting-congenital-heart-defects-a-comparison-of-three-data-mining-methods
#2
Yanhong Luo, Zhi Li, Husheng Guo, Hongyan Cao, Chunying Song, Xingping Guo, Yanbo Zhang
Congenital heart defects (CHD) is one of the most common birth defects in China. Many studies have examined risk factors for CHD, but their predictive abilities have not been evaluated. In particular, few studies have attempted to predict risks of CHD from, necessarily unbalanced, population-based cross-sectional data. Therefore, we developed and validated machine learning models for predicting, before and during pregnancy, women's risks of bearing children with CHD. We compared the results of these models in a large-scale, comprehensive population-based retrospective cross-sectional epidemiological survey of birth defects in six counties in Shanxi Province, China, covering 2006 to 2008...
2017: PloS One
https://www.readbyqxmd.com/read/28540268/effects-of-high-and-low-doses-of-folic-acid-on-the-soluble-receptor-activator-of-nuclear-factor-kappa-b-ligand-osteoprotegerin-ratio-during-pregnancy
#3
Nazila Fathi Maroufi, Amir Ghorbanihaghjo, Manizheh Sayyah Melli, Maryam Vaezi, Zohreh Hekmati Azar Mehrabani, Maryam Bannazadeh Amirkhiz, Nadereh Rashtchizadeh
BACKGROUND: Pregnancy Associated Osteoporosis (PAO) can lead to serious difficulties such as fragility fractures, elongated back pain and height loss in affected women. Soluble Receptor Activator of Nuclear Factor-Kappa B ligand (sRANKL) to Osteoprotegerin (OPG) ratio is chosen as a bone metabolism equation in many bone diseases characterized by bone resorption, such as post-menopausal osteoporosis and would be modified with folic acid supplementation. This study was done to compare the effects of high dose (5mg/day) and low dose (0...
April 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28537012/nutraceutical-effects-on-glucose-and-lipid-metabolism-in-patients-with-impaired-fasting-glucose-a-pilot-double-blind-placebo-controlled-randomized-clinical-trial-on-a-combined-product
#4
Arrigo Francesco Giuseppe Cicero, Federica Fogacci, Martino Morbini, Alessandro Colletti, Marilisa Bove, Maddalena Veronesi, Marina Giovannini, Claudio Borghi
INTRODUCTION: A number of natural compounds have individually demonstrated to improve glucose and lipid levels in humans. AIM: To  evaluate the short-term glucose and lipid-lowering activity in subjects with impaired fasting glucose. METHODS: To assess the effects of a combination of nutraceuticals based on Lagerstroemia speciosa, Berberis aristata, Curcuma longa, Alpha-lipoic acid, Chrome picolinate and Folic acid, we performed a double-blind, parallel group, placebo-controlled, randomized clinical trial in 40 adults affected by impaired fasting glucose (FPG = 100-125 mg/dL) in primary prevention of cardiovascular disease...
May 23, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28535307/intergenerational-impact-of-paternal-lifetime-exposures-to-both-folic-acid-deficiency-and-supplementation-on-reproductive-outcomes-and-imprinted-gene-methylation
#5
Lundi Ly, Donovan Chan, Mahmoud Aarabi, Mylène Landry, Nathalie A Behan, Amanda J MacFarlane, Jacquetta Trasler
STUDY QUESTION: Do paternal exposures to folic acid deficient (FD), and/or folic acid supplemented (FS) diets, throughout germ cell development adversely affect male germ cells and consequently offspring health outcomes? SUMMARY ANSWER: Male mice exposed over their lifetimes to both FD and FS diets showed decreased sperm counts and altered imprinted gene methylation with evidence of transmission of adverse effects to the offspring, including increased postnatal-preweaning mortality and variability in imprinted gene methylation...
May 23, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28534456/effects-of-folic-acid-fortification-on-orofacial-clefts-prevalence-a-meta-analysis
#6
Natalia Millacura, Rosa Pardo, Lucia Cifuentes, José Suazo
OBJECTIVE: Orofacial clefts (OFC) are the most prevalent craniofacial birth defect. Folic acid (FA) supplementation has been demonstrated as an effective intervention to reduce risk of OFC occurrence. However, the effect of mandatory FA fortification of wheat and/or maize flour on OFC prevalence has shown controversial results among countries adopting this policy. Thus, we performed a meta-analysis to synthesize the available evidence evaluating the global impact of this mandatory policy on OFC occurrence...
May 23, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28533154/preconception-and-prenatal-genetic-counselling
#7
REVIEW
Adonis S Ioannides
Identifying individuals at risk of having children affected by genetic conditions or congenital anomalies allows counselling that aims to inform reproductive decisions. This process takes place either at the preconception or early prenatal stage, although more options are available if risks are identified before the pregnancy. Preconception counselling covers issues that can affect the health of the mother and baby including folic acid supplementation. Carrier screening for autosomal recessive diseases, such as beta thalassaemia, has resulted in a significantly reduced incidence in many countries...
April 21, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28532129/-131-i-traced-plga-lipid-nanoparticles-as-drug-delivery-carriers-for-the-targeted-chemotherapeutic-treatment-of-melanoma
#8
Haiyan Wang, Weizhong Sheng
Herein, folic acid (FA) conjugated Poly(d,l-lactide-co-glycolide) (PLGA)-lipid composites (FA-PL) were developed as nanocarriers for the targeted delivery of insoluble anti-cancer drug paclitaxel (PTX), resulting FA-PLP nanoparticles. Furthermore, (131)I, as a radioactive tracer, was used to label FA-PLP nanoparticles (FA-PLP-(131)I) to evaluate their cell uptake activity, in vivo blood circulation, and biodistribution. The FA-PLP-(131)I nanoparticles had a spherical morphology with great stability, a narrow size distribution (165...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28531991/multifunctional-polymer-drug-loading-system-with-ph-sensitive-fluorescent-and-targeting-property
#9
Xuening Fei, Shubei Li, Lingyun Cao, Baolian Zhang, Miaozhuo Yu
IA multifunctional drug loading system with pH-sensitive, fluorescent and targeting property was fabricated. Firstly, the amphipathic N-octyl-N'-(2-carboxyl-cyclohexamethenyl) chitosan (OCCC) was prepared by grafting hydrophobic octyl group and hydrophilic hexahydrophthalic anhydride onto chitosan, then it was modified with folic acid (FA) and thiazole orange (TO) using polyethylene glycol (PEG) as the link to fabricate a multifunctional drug loading system TO-PEG-OCCC-PEG-FA. Its chemical structure was determined by Fourier transform infrared spectroscopy (FT-IR), elemental analysis, differential scanning calorimetry (DSC) analysis, UV-vis and fluorescence spectrometer, and the results showed that the substitution degree of hydrophobic/hydrophilic group onto chitosan were 41...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531877/folate-n-acetyl-glucosamine-conjugated-mesoporous-silica-nanoparticles-for-targeting-breast-cancer-cells-a-comparative-study
#10
Pramod Kumar, Prajakta Tambe, Kishore M Paknikar, Virendra Gajbhiye
Folate receptors (FR) have been well recognized as a marker to target nano-sized carriers for cancer diagnosis and therapy. In contrast, influx transport systems (e.g. GLUT transporters) that transport essential amino acids and nutrients to cancer cells have not been exploited much for targeted delivery. In this study, folic acid- or n-acetyl glucosamine- functionalized mesoporous silica nanoparticles loaded with doxorubicin (DOX-FA-MSNPs or DOX-NAG-MSNPs) were prepared, characterized and compared for targeting along with cytotoxicity towards MCF-7 and MDA-MB-231 human breast cancer cells...
May 11, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28529305/folic-acid-targeted-etoposide-cubosomes-for-theranostic-application-of-cancer-cell-imaging-and-therapy
#11
Yong Tian, Jian-Chun Li, Jin-Xiu Zhu, Na Zhu, Hong-Min Zhang, Lili Liang, Lingyi Sun
BACKGROUND The aim of this study was to develop a novel Poloxamer-based drug delivery system featuring a tumor-targeting folate moiety, which was expected to provide better targeting properties and therapeutic effects compared with the traditional cubosomes (Cubs). MATERIAL AND METHODS Both folate-modified Cubs containing etoposide (ETP-Cubs-FA) and normal cubic nanoparticles loaded with etoposide (ETP-Cubs) were prepared through the fragmentation of bulk gels under the homogenization condition of 1500 bar, and a mean particle size of around 180 nm was obtained with a narrow size distribution...
May 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28526386/the-effects-of-folic-acid-and-pyridoxine-supplementation-on-characteristics-of-migraine-attacks-in-migraine-patients-with-aura-a-double-blind-randomized-placebo-controlled-clinical-trial
#12
Gholamreza Askari, Morteza Nasiri, Hassan Mozaffari-Khosravi, Masod Rezaie, Mahdieh Bagheri-Bidakhavidi, Omid Sadeghi
OBJECTIVE: The aim of this study was to assess the effects of folic acid alone and in combination with pyridoxine on characteristics of migraine attacks in adult migraine patients with aura. METHODS: This double-blind, randomized placebo-controlled, clinical trial was conducted on 95 migraine patients with aura (age range 18-65 y) in Isfahan, Islamic Republic of Iran, in 2014. Patients were randomly allocated to receive folic acid (5 mg/d) plus pyridoxine (80 mg/d) or folic acid alone (5 mg/d) or placebo (lactose) for 3 mo...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28525949/capsaicin-loaded-folic-acid-conjugated-lipid-nanoparticles-for-enhanced-therapeutic-efficacy-in-ovarian-cancers
#13
Lin Lv, Yu-Xin Zhuang, Hui-Wu Zhang, Nan-Nan Tian, Wen-Zhen Dang, Shao-Yu Wu
In this study, folic acid-conjugated lipid nanoparticles were successfully prepared to enhance the active targeting of capsaicin (CAP) in ovarian cancers. The particles were nanosized and exhibited a controlled release of drug in the physiological conditions. The folic acid (FA)-conjugated system exhibited a remarkably higher uptake of nanoparticles in the cancer cells compared to that of non-targeted system. The folate-conjugated CAP-loaded lipid nanoparticles (CFLN) upon interacting with cancer cells were internalized via receptor-mediated endocytosis mechanism and resulted in higher concentration in the cancer cells...
May 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28515164/mrna-levels-of-placental-iron-and-zinc-transporter-genes-are-upregulated-in-gambian-women-with-low-iron-and-zinc-status
#14
Modou Lamin Jobarteh, Harry J McArdle, Grietje Holtrop, Ebrima A Sise, Andrew M Prentice, Sophie E Moore
Background: The role of the placenta in regulating micronutrient transport in response to maternal status is poorly understood.Objective: We investigated the effect of prenatal nutritional supplementation on the regulation of placental iron and zinc transport.Methods: In a randomized trial in rural Gambia [ENID (Early Nutrition and Immune Development)], pregnant women were allocated to 1 of 4 nutritional intervention arms: 1) iron and folic acid (FeFol) tablets (FeFol group); 2) multiple micronutrient (MMN) tablets (MMN group); 3) protein energy (PE) as a lipid-based nutrient supplement (LNS; PE group); and 4) PE and MMN (PE+MMN group) as LNS...
May 17, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28514181/folic-acid-modulates-dmba-tpa-induced-changes-in-skin-of-mice-a-study-relevant-to-carcinogenesis
#15
Ashwani Koul, Navneet Kaur, Neha Arora Chugh
The present study was aimed at investigating the modulatory effects of folic acid (FA) on early stages of chemically induced skin cancer. For this, a two-stage model of skin tumorigenesis was employed. 7,12-Dimethylbenz(a)anthracene (DMBA, 500 nmol/100 ul of acetone) was applied topically for two weeks (twice weekly), followed by phorbol-12-myristate-13-acetate (TPA, 1.7 nmol/100 ul) twice weekly for six weeks on the depilated skin of mice, and FA was administered orally at a dose of 40 microgram/animal for 10 weeks daily...
May 17, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28511688/predictors-of-adherence-to-micronutrient-supplementation-before-and-during-pregnancy-in-vietnam
#16
Ines Gonzalez-Casanova, Phuong Hong Nguyen, Melissa Fox Young, Kimberly B Harding, Greg Reinhart, Hieu Nguyen, Meredith Nechitillo, Truong V Truong, Hoa Pham, Son Nguyen, Lynnette M Neufeld, Reynaldo Martorell, Usha Ramakrishnan
BACKGROUND: Poor adherence to micronutrient supplementation often limits the effectiveness of public health programs. While predictors of adherence to micronutrient supplementation during pregnancy are well documented, information on adherence to preconception supplements is scarce. The objective of this study was to describe the predictors of adherence to preconception and prenatal micronutrient supplementation among women participating in a randomized control trial in Vietnam. METHODS: Adherence data were collected prospectively from a double blind randomized controlled trial in rural Vietnam...
May 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28511389/variability-of-iron-load-in-patients-of-sickle-cell-anaemia-hbss-a-study-from-eastern-india
#17
Pranati Mohanty, Rabindra Kumar Jena, Sudha Sethy
INTRODUCTION: Sickle Cell Anaemia (SCA) is one of the commonest haemoglobinopathies due to a point mutation (A→T) of the β-globin gene. Out of five haplotypes, the Arab-Indian haplotype present in India is one of the least severe phenotype and least studied also. It is characterized by lifelong haemolytic anaemia requiring red cell transfusion leading to iron overload. In contrast, there is very high incidence of deficiency of iron, folic acid and vitamin B12. AIM: Our objective was to access the Iron status of SCA patients and to find its correlation with various parameters like red cell transfusion, haemolysis and serum hepcidin...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28510997/impact-of-m-health-application-used-by-community-health-volunteers-on-improving-utilization-of-maternal-newborn-and-child-health-care-services-in-a-rural-area-of-uttar-pradesh-india
#18
Shankar Prinja, Ruby Nimesh, Aditi Gupta, Pankaj Bahuguna, Madhu Gupta, Jarnail Singh Thakur
OBJECTIVE: To raise the quality of counselling by community health volunteers resulting in improved uptake of maternal, neonatal and child health services (MNCH), an m-health application was introduced under a project named 'Reducing Maternal and Newborn Deaths (ReMiND)' in district Kaushambi in India. We report the impact of this project on coverage of key MNCH services. METHODS: A pre and post quasi-experimental design was undertaken to assess the impact of intervention...
May 16, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28507637/factors-influencing-antenatal-haematinics-prescription-behaviour-of-physicians-in-calabar-nigeria
#19
Ubong Akpan, Thomas Agan, Emmanuel Monjok, Chinedu Okpara, Saturday Etuk
BACKGROUND: Routine iron and folic acid supplementation in pregnancy have been proved to be effective in reducing the prevalence and morbidities of anaemia. However, there is limited data regarding the prescription habits of physician obstetric care givers. AIM: This study set to investigate the attitudes and factors which influence the practice among physicians in University of Calabar Teaching Hospital (UCTH). MATERIAL AND METHODS: A questionnaire based cross-sectional survey was conducted among randomly recruited physician offering antenatal services between August and September 2015...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28506268/ethnic-differences-in-folic-acid-supplement-use-in-a-population-based-cohort-of-pregnant-women-in-norway
#20
Tarja I Kinnunen, Line Sletner, Christine Sommer, Martine C Post, Anne Karen Jenum
BACKGROUND: Peri-conceptional use of folic acid supplements is recommended to prevent neural tube defects. Correct supplement use seems to be less common among ethnic minorities. We examined ethnic differences in folic acid supplement use before and during pregnancy and possible effect modification by education or planning of pregnancy. METHODS: The participants were 811 healthy pregnant women from a population-based cohort study in Oslo, Norway in 2008-2010. Ethnicity was categorized to five groups (European, Middle Eastern, South Asian, East Asian, African)...
May 15, 2017: BMC Pregnancy and Childbirth
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