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https://www.readbyqxmd.com/read/29778284/-clinical-and-epidemiological-profile-of-pediatric-uveitis-course-of-inflammatory-uveitis-treated-with-anti-tnf-alpha
#1
D Osswald, A C Rameau, C Speeg-Schatz, J Terzic, A Sauer
INTRODUCTION: Uveitis is the leading cause of acquired childhood blindness with a prevalence of 30 cases per 100,000 inhabitants. There are multiple causes ; nevertheless, there is no standardized etiological assessment. The goal of our study is to define an epidemiological and clinical profile of uveitis diagnosed in a university hospital and their course when treated with anti-tumor necrosis factor (TNF) α. PATIENTS AND METHODS: All cases of uveitis under 18 years old, from 1994 to 2016, were included...
May 16, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29776768/-topical-anesthesia-without-the-use-of-an-anesthesiologist-in-adult-outpatient-cataract-surgery-assessment-of-selection-criteria-on-consultation-report-of-248-cases
#2
M Pepin, E Rineau, A Caignard, S Leruez, P Gohier
INTRODUCTION: This work aims to evaluate selection criteria used during the cataract surgery scheduling visit, to choose whether or not there will be an anesthesiologist available during the surgery, depending upon the patient's comorbidities. MATERIALS AND METHODS: Retrospective study performed in 2016 in Angers university medical center. Two groups were established on the cataract surgery scheduling visit, based on patients' comorbidities and vital signs (blood pressure, heart rate)...
May 15, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29776377/shifts-in-borrelia-burgdorferi-s-l-geno-species-infections-in-ixodes-ricinus-over-a-10-year-surveillance-period-in-the-city-of-hanover-germany-and-borrelia-miyamotoi-specific-reverse-line-blot-detection
#3
Katrin Blazejak, Marie-Kristin Raulf, Elisabeth Janecek, Daniela Jordan, Volker Fingerle, Christina Strube
BACKGROUND: Lyme borreliosis caused by spirochetes of the Borrelia burgdorferi (sensu lato) complex is still the most common tick-borne disease in Europe, posing a considerable threat to public health. The predominant vector in Europe is the widespread hard tick Ixodes ricinus, which also transmits the relapsing fever spirochete B. miyamotoi as well as pathogenic Rickettsiales (Anaplasma phagocytophilum, Rickettsia spp.). To assess the public health risk, a long-term monitoring of tick infection rates with the named pathogens is indispensable...
May 18, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29773419/a-changing-etiologic-scenario-in-liver-transplantation-for-hepatocellular-carcinoma-in-a-multicenter-cohort-study-from-latin-america
#4
Federico Piñero, Paulo Costa, Yuri Longatto Boteon, Sergio Hoyos Duque, Sebastian Marciano, Margarita Anders, Adriana Varón, Alina Zerega, Jaime Poniachik, Alejandro Soza, Martín Padilla Machaca, Josemaría Menéndez, Rodrigo Zapata, Mario Vilatoba, Linda Muñoz, Martín Maraschio, Luis G Podestá, Lucas McCormack, Adrian Gadano, Ilka S F Fatima Boin, Parente García, Marcelo Silva
BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of hepatocellular carcinoma (HCC) and liver transplantation (LT). Our study focused on changing trends of liver related HCC etiologies during the last years in Latin America. METHODS: From a cohort of 2761 consecutive adult LT patients between 2005 and 2012 in 17 different centers, 435 with HCC were included. Different periods including years 2005-2006, 2007-2008, 2009-2010 and 2011-2012 were considered...
May 14, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29769040/novel-aggrecan-variant-p-gln2364pro-causes-severe-familial-nonsyndromic-adult-short-stature-and-poor-growth-hormone-response-in-chinese-children
#5
Dandan Xu, Chengjun Sun, Zeyi Zhou, Bingbing Wu, Lin Yang, Zhuo Chang, Miaoying Zhang, Li Xi, Ruoqian Cheng, Jinwen Ni, Feihong Luo
BACKGROUND: Mutations in the aggrecan (ACAN) gene can cause short stature (with heterogeneous clinical phenotypes), impaired bone maturation, and large variations in response to growth hormone (GH) treatment. For such cases, long-term longitudinal therapy data from China are still scarce. We report that a previously unknown ACAN gene variant reduces adult height and we analyze the GH response in children from an affected large Chinese family. METHODS: Two children initially diagnosed with idiopathic short stature (ISS) and a third mildly short child from a large Chinese family presented with poor GH response...
May 16, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29768078/wet-wrap-therapy-with-halometasone-cream-for-severe-adult-atopic-dermatitis
#6
Wei Xu, Yan Li, Zeyu Chen, Teng Liu, Shan Wang, Linfeng Li
BACKGROUND: Currently there is no cure for severe atopic dermatitis (AD). Wet-wrap therapy (WWT) has also been used to treat pediatric AD and shown a satisfactory effectiveness, but clinical evidence supporting the use of WWT on severe adult AD is still insufficient. METHODS: Twelve patients (8 men and 4 women) with severe AD (SCORing Atopic Dermatitis [SCORAD] score≥50) treated between January 2015 and September 2017 in our hospital were included. The patients underwent WWT (daily dose: 15g halometasone cream+100g Vaseline ointment) twice daily for 2 hours/session for 7 days...
May 16, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29765530/mean-platelet-volume-as-a-predictive-marker-for-venous-thromboembolism-in-patients-treated-for-hodgkin-lymphoma
#7
Joanna Rupa-Matysek, Lidia Gil, Marta Barańska, Dominik Dytfeld, Mieczysław Komarnicki
Mean platelet volume (MPV) is reported to be associated with the risk of venous thromboembolism (VTE) and mortality in patients with cancer. We sought to determine the association of MPV with symptomatic VTE occurrence in patients treated for newly diagnosed Hodgkin lymphoma (HL) and their outcomes. We retrospectively studied 167 consecutive adult patients treated with HL. During first-line treatment 12 (7.2%) patients developed VTE and 14 (8%) died within the observation period. The pre-chemotherapy values of MPV were significantly lower in VTE patients than those without (p=0...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29764407/are-we-doing-enough-to-prevent-poor-quality-antimalarial-medicines-in-the-developing-world
#8
Erin J Walker, Gregory M Peterson, James Grech, Evie Paragalli, Jackson Thomas
BACKGROUND: Malaria is a deadly parasitic disease that affects more than 3 billion people worldwide, in predominantly resource-poor countries. Despite malaria being preventable and treatable, a large number of adults and children, mostly in Africa, die from this disease each year. One contributor to needless morbidity and mortality is the production and distribution of poor-quality antimalarial medicines; indeed, it is estimated that over 122,000 deaths of children under 5 years of age in sub-Saharan countries were caused by poor-quality antimalarial medicines, in 2013 alone...
May 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29761075/transforming-growth-factor-%C3%AE-signaling-plays-a-pivotal-role-in-the-interplay-between-osteosarcoma-cells-and-their-microenvironment
#9
REVIEW
Franck Verrecchia, Françoise Rédini
Osteosarcomas are the most frequent form of primary bone tumors and mainly affect children, adolescents, and young adults. Despite encouraging progress in therapeutic management, including the advent of multidrug chemotherapy, the survival rates have remained unchanged for more than four decades: 75% at 5 years for localized disease, but two groups of patients are still at high risk: metastatic at diagnosis (overall survival around 40% at 5 years) and/or poor responders to chemotherapy (20% at 5 years)...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29759737/long-term-outcome-of-cryopreserved-allograft-for-aortic-valve-replacement
#10
Francesco Nappi, Antonio Nenna, Tommasangelo Petitti, Cristiano Spadaccio, Ivancarmine Gambardella, Mario Lusini, Massimo Chello, Christophe Acar
OBJECTIVE: The most efficient surgical approach to severe aortic valve disease in the young adult is still debated: cryopreserved aortic allograft offers excellent hemodynamic and avoid anticoagulation, but long-term durability is influenced by structural valve deterioration (SVD). This study aimed to describe long-term results of aortic allografts and to identify factors influencing long-term durability. METHODS: From January 1993 to August 2010, 210 patients underwent aortic allograft replacement via the free-hand subcoronary implantation technique (N = 55) or root replacement with coronary reimplantation (N = 155)...
April 18, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29758057/ankk1-is-found-in-myogenic-precursors-and-muscle-fibers-subtypes-with-glycolytic-metabolism
#11
Estrella Rubio-Solsona, Salvador Martí, Juan J Vílchez, Francesc Palau, Janet Hoenicka
Ankyrin repeat and kinase domain containing 1 (ANKK1) gene has been widely related to neuropsychiatry disorders. The localization of ANKK1 in neural progenitors and its correlation with the cell cycle has suggested its participation in development. However, ANKK1 functions still need to be identified. Here, we have further characterized the ANKK1 localization in vivo and in vitro, by using immunolabeling, quantitative real-time PCR and Western blot in the myogenic lineage. Histologic investigations in mice and humans revealed that ANKK1 is expressed in precursors of embryonic and adult muscles...
2018: PloS One
https://www.readbyqxmd.com/read/29756562/perspectives-and-new-aspects-of-metalloproteinases-inhibitors-in-therapy-of-cns-disorders-from-chemistry-to-medicine
#12
Anna Boguszewska-Czubara, Barbara Budzynska, Krystyna Skalicka-Wozniak, Jacek Kurzepa
Matrix metalloproteinases (MMPs) play a key role in remodelling of the extracellular matrix (ECM) and, at the same time, influence cell differentiation, migration, proliferation and survival. Their importance in variety of human diseases including cancer, rheumatoid arthritis, pulmonary emphysema and fibrotic disorders has been known for many years but special attention should be paid on the role of MMPs in the central nervous system (CNS) disorders. Till now, there are not many well documented physiological MMP target proteins in the brain and only some pathological ones...
May 13, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29754764/monitoring-of-early-humoral-immunity-to-identify-lung-recipients-at-risk-for-development-of-serious-infections-a-multicenter-prospective-study
#13
Elizabeth Sarmiento, Jose Cifrian, Leticia Calahorra, Carles Bravo, Sonia Lopez, Rosalia Laporta, Piedad Ussetti, Amparo Sole, Carmen Morales, Alicia de Pablos, Maria Jaramillo, Ikram Ezzahouri, Sandra García, Joaquin Navarro, Marcos Lopez-Hoyos, Javier Carbone
BACKGROUND: Infection is still a leading cause of death during the first year after lung transplantation. We performed a multicenter study among teaching hospitals to assess monitoring of early humoral immunity as a means of identifying lung recipients at risk of serious infections. METHODS: We prospectively analyzed 82 adult lung recipients at 5 centers in Spain. Data were collected before transplantation and at 7 and 30 days after transplantation. Biomarkers included IgG, IgM, IgA, complement factors C3 and C4, titers of antibodies to pneumococcal polysaccharide antigens (IgG, IgA, IgM) and antibodies to cytomegalovirus (IgG), and serum B-cell activating factor (BAFF) levels...
April 6, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29751825/uneven-malaria-transmission-in-geographically-distinct-districts-of-bobo-dioulasso-burkina-faso
#14
Dieudonné Diloma Soma, Daouda Kassié, Seydou Sanou, Fatou Biribama Karama, Ali Ouari, Wadaka Mamai, Georges Anicet Ouédraogo, Gérard Salem, Roch Kounbobr Dabiré, Florence Fournet
BACKGROUND: Urbanization is a main trend in developing countries and leads to health transition. Although non-communicable diseases are increasing in cities of low-income countries, vector-borne diseases such as malaria, are still present. In the case of malaria, transmission is lower than in rural areas, but is uneven and not well documented. In this study, we wanted to evaluate intra-urban malaria transmission in a West African country (Burkina Faso). METHODS: A cross-sectional study on 847 adults (35 to 59 year-old) and 881 children (6 months to 5 year-old) living in 1045 households of four districts (Dogona, Yeguere, Tounouma and Secteur 25) of Bobo-Dioulasso was performed between October and November 2013...
May 11, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29750804/temporal-compartmental-changes-in-viral-rna-and-neuronal-injury-in-a-primate-model-of-neuroaids
#15
R Gilberto González, Robert Fell, Julian He, Jennifer Campbell, Tricia H Burdo, Patrick Autissier, Lakshmanan Annamalai, Faramarz Taheri, Termara Parker, Jeffrey D Lifson, Elkan F Halpern, Mark Vangel, Eliezer Masliah, Susan V Westmoreland, Kenneth C Williams, Eva-Maria Ratai
Despite the advent of highly active anti-retroviral therapy HIV-associated neurocognitive disorders (HAND) continue to be a significant problem. Furthermore, the precise pathogenesis of this neurodegeneration is still unclear. The objective of this study was to examine the relationship between infection by the simian immunodeficiency virus (SIV) and neuronal injury in the rhesus macaque using in vivo and postmortem sampling techniques. The effect of SIV infection in 23 adult rhesus macaques was investigated using an accelerated NeuroAIDS model...
2018: PloS One
https://www.readbyqxmd.com/read/29747666/survival-of-rats-bearing-advanced-intracerebral-f-98-tumors-after-glutathione-depletion-and-microbeam-radiation-therapy-conclusions-from-a-pilot-project
#16
E Schültke, E Bräuer-Krisch, H Blattmann, H Requardt, J A Laissue, G Hildebrandt
BACKGROUND: Resistance to radiotherapy is frequently encountered in patients with glioblastoma multiforme. It is caused at least partially by the high glutathione content in the tumour tissue. Therefore, the administration of the glutathione synthesis inhibitor Buthionine-SR-Sulfoximine (BSO) should increase survival time. METHODS: BSO was tested in combination with an experimental synchrotron-based treatment, microbeam radiation therapy (MRT), characterized by spatially and periodically alternating microscopic dose distribution...
May 10, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29746798/the-burden-of-influenza-a-and-b-in-mexico-from-the-year-2010-to-2013-an-observational-retrospective-database-study-on-records-from-the-directorate-general-of-epidemiology-database
#17
Ricardo Cortes-Alcala, Gaël Dos Santos, Rodrigo DeAntonio, Raghavendra Devadiga, Cuitlahuac Ruiz-Matus, Maria E Jimenez-Corona, Jose A Diaz-Quinonez, Luis Romano-Mazzotti, Maria Yolanda Cervantes-Apolinar, Pablo Kuri-Morales
Despite vaccination programs, influenza still represents a significant disease burden in Mexico. We conducted an observational, retrospective analysis to better understand the epidemiological situation of the influenza virus in Mexico. Analysis of the seasonal patterns of influenza A and B were based on the Directorate General of Epidemiology dataset of influenza-like illness(ILI), and severe acute respiratory infection(SARI) that were recorded between January 2010 and December 2013. Our objectives were 1) to describe influenza A and B activity, by age group, and subtype and, 2) to analyze the number of laboratory-confirmed cases presenting with ILI by influenza type, the regional distribution of influenza, and its clinical features...
May 10, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29745089/hpv-infection-in-oropharyngeal-squamous-cell-carcinomas-correlation-with-tumor-size
#18
Eleftheria Gletsou, Theodoros A Papadas, Evangelia Baliou, Evangelos Tsiambas, Vasileios Ragos, Ilianna E Armata, George E Metaxas, Panagiotis P Fotiades
PURPOSE: Human papillomavirus (HPV) is implicated in carcinogenesis of a variety of epithelia, including oropharyngeal and laryngeal. High risk (HR) HPV persistent infection in head and neck squamous cell carcinomas (HNSCC) is a significant event, but its influence regarding the prognosis and survival in these patients remains under consideration. Our aim was to analyze a series of oropharyngeal (OP) SCCs at the HPV DNA level, correlating them to the survival status of the corresponding patients...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29743722/management-of-patients-with-acute-promyelocytic-leukemia
#19
REVIEW
Sabine Kayser, Richard F Schlenk, Uwe Platzbecker
With the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) acute promyelocytic leukemia (APL) has become from a detrimental to one of the most curable malignant diseases in humans. In particular, the chemotherapy-free regimen with ATO/ATRA has been proven to be highly effective in de novo APL and has become standard first-line therapy in younger adult, non-high-risk patients. Nevertheless, early death is still a major issue in APL, particularly in older patients, emphasizing the need of rapid diagnostics and supportive care together with immediate access to ATRA-based therapy...
April 24, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29743387/suhexiang-essential-oil-inhalation-produces-antidepressant-and-anxiolytic-like-effects-in-adult-mice
#20
Min Liang, Yuru Du, Wenjing Li, Xi Yin, Ni Yang, Anran Qie, Tyler W LeBaron, Jiayu Zhang, Haiying Chen, Haishui Shi
SuHeXiang (SHX) has been used to treat a wide range of diseases, including those related to the central nervous system. However, the effects of SHX on mood disorders are still elusive. This study aimed to investigate the effects of SHX essential oil on stress-induced depression of mice. In an acute stress-induced depression model, mice inhaled vehicle (1% Tween80) for 10 min or 10% SHX for 10 or 30 min once daily for 12 continuous days. In the chronic mild stress (CMS)-induced depression model, mice were exposed to a 28-d CMS treatment...
May 9, 2018: Biological & Pharmaceutical Bulletin
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