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https://www.readbyqxmd.com/read/29032095/a-review-on-environmental-monitoring-of-water-organic-pollutants-identified-by-eu-guidelines
#1
REVIEW
João C G Sousa, Ana R Ribeiro, Marta O Barbosa, M Fernando R Pereira, Adrián M T Silva
The contamination of fresh water is a global concern. The huge impact of natural and anthropogenic organic substances that are constantly released into the environment, demands a better knowledge of the chemical status of Earth's surface water. Water quality monitoring studies have been performed targeting different substances and/or classes of substances, in different regions of the world, using different types of sampling strategies and campaigns. This review article aims to gather the available dispersed information regarding the occurrence of priority substances (PSs) and contaminants of emerging concern (CECs) that must be monitored in Europe in surface water, according to the European Union Directive 2013/39/EU and the Watch List of Decision 2015/495/EU, respectively...
October 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29030657/meloxicam-and-risk-of-myocardial-infarction-a-population-based-nested-case-control-study
#2
Deepan Dalal, Maureen Dubreuil, Christine Peloquin, Tuhina Neogi, Yuqing Zhang, Hyon Choi, David Felson
Certain non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with an increased risk of myocardial infarction (MI), a risk linked to cyclo-oxygenase-2 inhibition. There are limited studies assessing the risk of MI associated with meloxicam, an increasingly popular drug with COX-2 inhibiting properties. A nested matched case-control study using The Health Improvement Network, a UK population-based database was conducted. NSAID users between 35 and 89 years of age with at least 1 year enrollment in the cohort were included...
October 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29020251/differential-blood-pressure-effects-of-ibuprofen-naproxen-and-celecoxib-in-patients-with-arthritis-the-precision-abpm-prospective-randomized-evaluation-of-celecoxib-integrated-safety-versus-ibuprofen-or-naproxen-ambulatory-blood-pressure-measurement-trial
#3
Frank Ruschitzka, Jeffrey S Borer, Henry Krum, Andreas J Flammer, Neville D Yeomans, Peter Libby, Thomas F Lüscher, Daniel H Solomon, M Elaine Husni, David Y Graham, Deborah A Davey, Lisa M Wisniewski, Venu Menon, Rana Fayyad, Bruce Beckerman, Dinu Iorga, A Michael Lincoff, Steven E Nissen
Aims: Non-steroidal anti-inflammatory drugs (NSAIDs), both non-selective and selective cyclooxygenase-2 (COX-2) inhibitors, are among the most widely prescribed drugs worldwide, but associate with increased blood pressure (BP) and adverse cardiovascular (CV) events. PRECISION-ABPM, a substudy of PRECISION was conducted at 60 sites, to determine BP effects of the selective COX-2 inhibitor celecoxib vs. the non-selective NSAIDs naproxen and ibuprofen. Methods and results: In this double-blind, randomized, multicentre non-inferiority CV-safety trial, 444 patients (mean age 62 ± 10 years, 54% female) with osteoarthritis (92%) or rheumatoid arthritis (8%) and evidence of or at increased risk for coronary artery disease received celecoxib (100-200 mg bid), ibuprofen (600-800 mg tid), or naproxen (375-500 mg bid) with matching placebos in a 1: 1: 1 allocation, to assess the effect on 24-h ambulatory BP after 4 months...
August 28, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28993650/development-of-a-machine-learning-algorithm-to-classify-drugs-of-unknown-fetal-effect
#4
Mary Regina Boland, Fernanda Polubriaginof, Nicholas P Tatonetti
Many drugs commonly prescribed during pregnancy lack a fetal safety recommendation - called FDA 'category C' drugs. This study aims to classify these drugs into harmful and safe categories using knowledge gained from chemoinformatics (i.e., pharmacological similarity with drugs of known fetal effect) and empirical data (i.e., derived from Electronic Health Records). Our fetal loss cohort contains 14,922 affected and 33,043 unaffected pregnancies and our congenital anomalies cohort contains 5,658 affected and 31,240 unaffected infants...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28991796/continuous-transformation-of-chiral-pharmaceuticals-in-enzymatic-membrane-bioreactors-for-advanced-wastewater-treatment
#5
Luong N Nguyen, Faisal I Hai, James A McDonald, Stuart J Khan, William E Price, Long D Nghiem
This study demonstrates continuous enantiomeric inversion and further biotransformation of chiral profens including ibuprofen, naproxen and ketoprofen by an enzymatic membrane bioreactor (EMBR) dosed with laccase. The EMBR showed non-enantioselective transformations, with high and consistent transformation of both (R)- and (S)-ibuprofen (93 ± 6%, n = 10), but lower removals of both enantiomers of naproxen (46 ± 16%, n = 10) and ketoprofen (48 ± 17%, n = 10). Enantiomeric analysis revealed a bidirectional but uneven inversion of the profens, for example 14% inversion of (R)- to (S)- compared to 4% from (S)- to (R)-naproxen...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28991111/an-intraplantar-hypertonic-saline-assay-in-mice-for-rapid-screening-of-analgesics
#6
Yahya I Asiri, Timothy Fung, Stephan K W Schwarz, Khalid A Asseri, Ian D Welch, Catherine A Schuppli, Alasdair M Barr, Richard A Wall, Ernest Puil, Bernard A MacLeod
BACKGROUND: Development of new analgesics is limited by shortcomings of existing preclinical screening assays such as wide variations in response, suitability for a narrow range of analgesics, and propensity to induce tissue damage. Our aim was to determine the feasibility of a new in vivo animal assay as an analgesic screen based on nociceptive responses (licking and biting) after intraplantar (i.pl.) injection of hypertonic saline (HS) in mice. METHODS: With approval from the Institutional Animal Care Committee, we conducted a randomized, investigator-blinded in vivo study in adult CD-1 mice...
October 5, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28987928/synthesis-and-gelation-property-of-a-series-of-disaccharide-triazole-derivatives
#7
Ifeanyi S Okafor, Guijun Wang
Low molecular weight gelators are important for the study of supramolecular chemistry and have useful applications for biomaterials. Glycomimetics that are easily accessible and have useful gelation properties are especially interesting molecules. In this research, nine per-O-acetyl lactosyl- and thirteen per-O-acetyl maltosyl triazole derivatives were synthesized and analyzed. Most of the maltosyl triazoles and one of the lactosyl derivatives were found to be effective molecular gelators. The supramolecular gels were characterized using rheology and optical microscopy and they exhibited morphologies ranging from fibers to planar sheets...
September 15, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28987485/naproxen-gel-probably-has-no-important-benefit-in-minimizing-pain-after-orthodontic-separator-placement
#8
Romina Brignardello-Petersen
No abstract text is available yet for this article.
October 4, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28978633/international-union-of-basic-and-clinical-pharmacology-cii-pharmacological-modulation-of-h2s-levels-h2s-donors-and-h2s-biosynthesis-inhibitors
#9
REVIEW
Csaba Szabo, Andreas Papapetropoulos
Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous gasotransmitter in mammalian cells and tissues. Similar to the previously characterized gasotransmitters nitric oxide and carbon monoxide, H2S is produced by various enzymatic reactions and regulates a host of physiologic and pathophysiological processes in various cells and tissues. H2S levels are decreased in a number of conditions (e.g., diabetes mellitus, ischemia, and aging) and are increased in other states (e.g., inflammation, critical illness, and cancer)...
October 2017: Pharmacological Reviews
https://www.readbyqxmd.com/read/28977822/blocking-epithelial-to-mesenchymal-transition-in-glioblastoma-with-a-sextet-of-repurposed-drugs-the-eis-regimen
#10
Richard E Kast, Nicolas Skuli, Georg Karpel-Massler, Guido Frosina, Timothy Ryken, Marc-Eric Halatsch
This paper outlines a treatment protocol to run alongside of standard current treatment of glioblastoma- resection, temozolomide and radiation. The epithelial to mesenchymal transition (EMT) inhibiting sextet, EIS Regimen, uses the ancillary attributes of six older medicines to impede EMT during glioblastoma. EMT is an actively motile, therapy-resisting, low proliferation, transient state that is an integral feature of cancers' lethality generally and of glioblastoma specifically. It is believed to be during the EMT state that glioblastoma's centrifugal migration occurs...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976921/in-vitro-evaluation-of-third-generation-pamam-dendrimer-conjugates
#11
Mohammad Najlah, Sally Freeman, Mouhamad Khoder, David Attwood, Antony D'Emanuele
The present study compares the use of high generation G3 and low generation G0 Polyamidoamine (PAMAM) dendrimers as drug carriers of naproxen (NAP), a poorly water soluble drug. Naproxen was conjugated to G3 in different ratios and to G0 in a 1:1 ratio via a diethylene glycol linker. A lauroyl chain (L), a lipophilic permeability enhancer, was attached to G3 and G0 prodrugs. The G3 and G0 conjugates were more hydrophilic than naproxen as evaluated by the measurement of partitioning between 1-octanol and a phosphate buffer at pH 7...
October 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28969905/determination-of-the-bioavailability-of-selected-pharmaceutical-residues-in-fish-plasma-using-liquid-chromatography-coupled-to-tandem-mass-spectrometry
#12
S Poirier Larabie, M Houde, C Gagnon
Aquatic systems near major urban centers are constantly contaminated with effluent from wastewater treatment plants. Pharmaceuticals are part of the contamination and several classes of drugs have been detected in surface waters in the last decade. To better understand the impact of those pharmaceuticals in ecosystems, the exposure to aquatic species needs to be investigated. This study presents a new simple and rugged quantitative method for the determination of several classes of drugs using 100μL of plasma from fish environmentally exposed to a major but highly diluted urban effluent...
September 27, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28962074/study-of-pharmaceuticals-in-surface-and-wastewater-from-cuernavaca-morelos-mexico-occurrence-and-environmental-risk-assessment
#13
José Abraham Rivera-Jaimes, Cristina Postigo, Rosa María Melgoza-Alemán, Jaume Aceña, Damia Barceló, Miren López de Alda
The present work describes the first known study to date on the occurrence of pharmaceuticals in surface water and wastewater of Cuernavaca, the capital of the state of Morelos (México). Selected pharmaceuticals (a total of 35) were extracted from the collected water samples with a generic solid phase extraction (SPE) protocol and determined in the sample extracts by means of high-performance liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS). A screening level risk assessment combining the measured environmental concentrations (MECs) with dose-response data based on predicted no-effect concentrations (PNECs) was also applied to estimate Hazard Quotients (HQs) for the pharmaceuticals detected in the investigated area...
September 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28961427/comparison-of-clinical-efficacies-of-preoperatively-initiated-naproxen-sodium-codeine-phosphate-in-combination-diclofenac-potassium-and-benzydamine-hydrochloride-for%C3%A2-pain-edema-and-trismus-after%C3%A2-extraction-of-impacted-lower%C3%A2-third-molar-a-randomized-double
#14
Levent Cigerim, Cennet Neslihan Eroglu
PURPOSE: The aim of this study was to compare the clinical efficacies of naproxen sodium-codeine phosphate in combination, benzydamine hydrochloride, and diclofenac potassium for pain, edema, and trismus after lower third molar extraction. MATERIALS AND METHODS: Ninety healthy volunteers in whom impacted third molar extraction was indicated were randomly distributed into 3 groups. One hour before the tooth-extraction process, patients were administered one of the following drugs: naproxen sodium, 550 mg, and codeine phosphate, 30 mg, in a tablet; diclofenac potassium, 50 mg, in a coated pill; or benzydamine hydrochloride, 50 mg, in a coated pill...
September 8, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28960241/intensive-vaginal-dilation-using-adjuvant-treatments-in-women-with-mayer-rokitansky-kuster-hauser-syndrome-retrospective-cohort-study
#15
Ashradha Ketheeswaran, Jennifer Morrisey, Jason Abbott, Michael Bennett, Jan Dudley, Rebecca Deans
AIMS: To evaluate the effect of adjuvants during intensive vaginal dilator therapy for functional and anatomical neovagina creation in women with Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH). METHODS: This retrospective cohort study included 75 women with MRKH undergoing intensive vaginal dilator treatment between 2000 and 2014. One specialist nurse performed non-surgical vaginal dilation aided by adjuvants, during inpatient admissions for several dilation sessions per day...
September 28, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28947204/preparation-of-a-reversed-phase-anion-exchange-mixed-mode-spherical-sorbent-by-pickering-emulsion-polymerization-for-highly-selective-solid-phase-extraction-of-acidic-pharmaceuticals-from-wastewater
#16
Chaonan Huang, Yun Li, Jiajia Yang, Junyu Peng, Jing Jin, Dhanjai, Jincheng Wang, Jiping Chen
The present work represents a simple and effective preparation of a novel mixed-mode anion-exchange (MAX) sorbent based on porous poly[2-(diethylamino)ethyl methacrylate-divinylbenzene] (poly(DEAEMA-DVB)) spherical particles synthesized by one-step Pickering emulsion polymerization. The poly(DEAEMA-DVB) particles were quaternized with 1,4-butanediol diglycidyl ether (BDDE) followed by triethylamine (TEA) via epoxy-amine reaction to offer strong anion exchange properties. The synthesized MAX sorbent was characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, nitrogen adsorption-desorption measurements and elemental analysis...
September 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28939402/improving-the-drug-release-of-naproxen-sodium-tablets-by-preparing-granules-and-tablets-with-a-preferred-mixing-ratio-of-hydrates
#17
Bär David, Debus Heiko, Grune Christian, Tosch Stephan, Fischer Wolfgang, Mäder Karsten, Imming Peter
Naproxen is a typical and well-known analgesic classified as non-steroidal anti-inflammatory drug (NSAID) and is commercialized as tablets or liquid-filled capsules. Naproxen is typically used as a sodium salt because of its better processability compared to Naproxen free acid. This entails hygroscopicity and gives rise to the existence of four different hydrates, which show polymorphic and pseudopolymorphic properties. Solid dosage forms containing Naproxen Sodium often have to be processed in an applicable dosage form by granulation and tablet compression...
September 19, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28938216/efficient-removal-of-priority-hazardous-priority-and-emerging-pollutants-with-prunus-armeniaca-functionalized-biochar-from-aqueous-wastes-experimental-optimization-and-modeling
#18
Maja Turk Sekulić, Sabolč Pap, Zoran Stojanović, Nikola Bošković, Jelena Radonić, Tatjana Šolević Knudsen
This paper investigates the ability of the phosphoric acid functionalized Prunus armeniaca stones biochar (AsPhA) prepared by thermochemical activation to remove lead (Pb(2+)), cadmium (Cd(2+)), nickel (Ni(2+)), naproxen and chlorophenols from aqueous wastes. The engineered biochar was characterized using the Scanning Electron Microscopy, Energy-dispersive X-ray Spectroscopy, Fourier Transform Infrared Spectroscopy and Brunauer, Emmett and Teller technique. The batch studies were performed by varying the initial pH of the solution (2-9), adsorbent dosage (0...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28921415/comparing-the-safety-and-efficacy-of-celecoxib-for-the-treatment-of-osteoarthritis-in-asian-and-non-asian-populations-an-analysis-of-data-from-two-randomized-double-blind-placebo-controlled-active-comparator-trials
#19
Andri Lubis, Wei Wang, Graça Lima, Rana Fayyad, Chris Walker
INTRODUCTION: Celecoxib is an effective treatment for pain associated with osteoarthritis. There are differences in patient demographics among ethnic groups, with Asian populations typically smaller in body size. As a consequence, there may be a perception that celecoxib is less effective, or has poorer tolerability in Asian patients. METHODS: This analysis compares data from two multicenter, randomized, double-blind, placebo-controlled, active-comparator trials of celecoxib for the treatment of osteoarthritis of the knee: one study in Asian patients and the other in a mixed population comprised mostly of non-Asian patients (from which Asian patients were excluded for this analysis)...
September 18, 2017: Pain and Therapy
https://www.readbyqxmd.com/read/28915479/effect-of-design-and-operational-conditions-on-the-performance-of-subsurface-flow-treatment-wetlands-emerging-organic-contaminants-as-indicators
#20
Stefanie Kahl, Jaime Nivala, Manfred van Afferden, Roland A Müller, Thorsten Reemtsma
Six pilot-scale subsurface flow treatment wetlands loaded with primary treated municipal wastewater were monitored over one year for classical wastewater parameters and a set of emerging organic compounds (EOCs) serving as process indicators for biodegradation: caffeine, ibuprofen, naproxen, benzotriazole, diclofenac, acesulfame, and carbamazepine. The wetland technologies investigated included conventional horizontal flow, unsaturated vertical flow (single and two-stage), horizontal flow with aeration, vertical flow with aeration, and reciprocating...
November 15, 2017: Water Research
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