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Paola Mura, Serena Orlandini, Marzia Cirri, Francesca Maestrelli, Natascia Mennini, Giada Casella, Sandra Furlanetto
The work was aimed at developing an in vitro method able to provide rapid and reliable evaluation of drug absorption through buccal mucosa. Absorption simulator apparatus endowed with an artificial membrane was purposely developed by experimental design. The apparent permeation coefficient (Papp ) through excised porcine buccal mucosa of naproxen, selected as model drug, was the target value to obtain with the artificial membrane. The multivariate approach enabled systematic evaluation of the effect on the response (Papp ) of simultaneous variations of the variables (kind of lipid components for support impregnation and relative amounts)...
June 13, 2018: International Journal of Pharmaceutics
Hida Nierenburg, Katelin Jackfert
PURPOSE OF REVIEW: Headaches due to airplane travel are rare but documented in the literature. We aim to provide a review of diagnostic criteria and treatment for this condition. RECENT FINDINGS: Several cases of this syndrome have been reported since it was first described in 2004. Airplane headache is classified as unilateral, stabbing, orbito-frontal pain, lasting under 30 min, and occurs during ascent or descent of a plane. Patients with this condition can develop anxiety and fear of flying given the intensity and severity of the pain...
June 14, 2018: Current Pain and Headache Reports
Adam J Singer, Henry Towery, Steve A McClain
OBJECTIVES: A major goal of burn management is to reduce the progression of necrosis in the zone of ischemia surrounding the central zone of necrosis. A rat comb burn model is often used to assess the progression of necrosis in the zone of ischemia. We compared various combinations of naproxen [NPX], N-acetyl cysteine [NAC], and tadalafil [TD] (a phosphodiesterase-5 inhibitor used as a vasodilator to treat erectile dysfunction) in a rat comb burn model to determine their effects on injury progression...
June 9, 2018: Burns: Journal of the International Society for Burn Injuries
Zuhair Alqahtani, Fakhreddin Jamali
PURPOSE: Concomitant use of some non-Aspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) reduces the extent of platelet aggregation of Aspirin (acetylsalicylic acid). This is while many observational studies and clinical trials suggest that Aspirin reduces cardiovascular (CV) risk attributed to the use of NANSAIDs. Thus, the therapeutic outcome of the interaction needs to be assessed. METHODS: We searched various databases up to October 2017 for molecular interaction studies between the drugs and long-term clinical outcomes based on randomized clinical trials and epidemiological observations that reported the effect estimates of CV risks (OR, RR or HR; 95% CI) of the interacting drugs alone or in combinations...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Richard L Kahn, Jennifer Cheng, Yuliya Gadulov, Kara G Fields, Jacques T YaDeau, Lawrence V Gulotta
BACKGROUND AND OBJECTIVES: Perineural dexamethasone and intravenous (IV) dexamethasone have been shown to prolong peripheral nerve block duration. The effects of perineural and IV dexamethasone have only been compared at doses of 4 mg or greater. This triple-blind, randomized trial examined the effect of 1 mg IV versus perineural dexamethasone on interscalene block (ISB) analgesia duration. METHODS: Patients undergoing ambulatory shoulder arthroscopy received an ultrasound-guided ISB with 15 mL bupivacaine 0...
June 8, 2018: Regional Anesthesia and Pain Medicine
Yujie He, Nora B Sutton, Yu Lei, Huub H M Rijnaarts, Alette A M Langenhoff
Removal of pharmaceutically active compounds (PhACs) in constructed wetlands (CWs) is a complex interplay of different processes. We studied fate and distribution of seven PhACs (caffeine, CAF; naproxen, NAP; metoprolol, MET; propranolol, PRO; ibuprofen, IBP; carbamazepine, CBZ; diclofenac, DFC) in mesocosm CWs and effects of irradiation via pre-photocatalysis, substrate composition (mainly sediment) through addition of litter (dead plant biomass), and plants. CWs showed high removal of CAF, NAP, MET, PRO, and IBP (79-99%)...
May 22, 2018: Journal of Hazardous Materials
Wan Nazihah Wan Ibrahim, Mohd Marsin Sanagi, Nor Suhaila Mohamad Hanapi, Sazlinda Kamaruzaman, Noorfatimah Yahaya, Wan Aini Wan Ibrahim
We describe the preparation, characterization and application of a composite film adsorbent based on blended agarose-chitosan-multi-walled carbon nanotubes for the preconcentration of selected non-steroidal anti-inflammatory drugs in aqueous samples before determination by high-performance liquid chromatography with UV detection. The composite film showed high surface area (4.0258 m2 /g) and strong hydrogen bonding between multi-walled carbon nanotubes and agarose/chitosan matrix, which prevent adsorbent deactivation and ensure long-term stability...
June 7, 2018: Journal of Separation Science
Fang-Fang Yang, Zai-Xuan Li, Yu-Jing Xu, Yan-Ping Huang, Zhao-Sheng Liu
The dendritic effect of nano mesoporous molecular sieve was first used to enhance molecular recognition of molecularly imprinted polymers (MIPs)-based polyhedral oligomeric silsesquioxanes (POSS). In this study, the MIPs were made using S-naproxen (S-NAP) as template molecule, 4-vinylpyridine (4-VP) as functional monomer, ethylene glycol dimethacrylate as cross-linker, 1-butyl-3-methylimidazoliumtetrafluoroborate ([BMIM]BF4 )/DMSO as binary porogens, 1-propylmethacrylate-heptaisobutyl substituted as POSS monomer, and mesoporous molecular sieve (Mobil composition of matter No...
June 7, 2018: Analytical and Bioanalytical Chemistry
Tomasz Z Osmałek, Anna Froelich, Marcin Soból, Bartłomiej Milanowski, Marcin Skotnicki, Paweł Kunstman, Mirosław Szybowicz
Aims After oral administration, naproxen generates several side-effects related to stomach malfunction. Undoubtedly, the enteric dosage forms with naproxen can be considered as safer. Moreover, since it has been evidenced that development and growth of colorectal cancer is related to the presence of cyclooxygenase, naproxen is investigated in terms of the tumor prevention. The aim of the present work was to formulate and evaluate the properties of novel naproxen-loaded macrobeads, made on the basis of low-acyl gellan gum and its blends with carrageenans, guar gum, cellulose sulfate, and dextran sulfates...
January 1, 2018: Journal of Biomaterials Applications
Arnoud de Wilt, Yujie He, Nora Sutton, Alette Langenhoff, Huub Rijnaarts
This study explored the removal of six pharmaceutically active compounds (PhACs) in lab-scale experiments with sediments under four redox conditions, namely aerobic, nitrate reducing, sulfate reducing, and methanogenic conditions using batch and column set-ups. Redox conditions were found to influence PhAC removal by sorption and biodegradation. The most optimal PhAC removal was observed at the outer ranges of the redox spectrum, i.e. either aerobic or deep anaerobic (sulfate reducing and methanogenic conditions), whereas nitrate reducing conditions were found least effective for PhACs biodegradation and sorption...
February 2018: Chemosphere
Elyse E Lower, Mahmoud Charif, Meg Bartelt
BACKGROUND: Chemotherapy for breast cancer is associated with a high risk of neutropenia. Pegfilgrastim reduces the risk of neutropenic fever but commonly causes bone pain. OBJECTIVE: Evaluate whether a reduced dose of pegfilgrastim (3 mg) reduced the frequency of bone pain without compromising efficacy. METHODS: Records reviewed from breast cancer patients who received at least one 3 mg dose of pegfilgrastim, white blood count (WBC), and absolute granulocyte counts (AGC) were collected...
June 5, 2018: Cancer Chemotherapy and Pharmacology
M Lundborg, C L Wennberg, A Narangifard, E Lindahl, L Norlén
Understanding and predicting permeability of compounds through skin is of interest for transdermal delivery of drugs and for toxicity predictions of chemicals. We show, using a new atomistic molecular dynamics model of the skin's barrier structure, itself validated against near-native cryo-electron microscopy data from human skin, that skin permeability to the reference compounds benzene, DMSO (dimethyl sulfoxide), ethanol, codeine, naproxen, nicotine, testosterone and water can be predicted. The permeability results were validated against skin permeability data in the literature...
June 1, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Per Falås, Kevin S Jewell, Nina Hermes, Arne Wick, Thomas A Ternes, Adriano Joss, Jeppe Lund Nielsen
A tiered process was developed to assess the transformation, CO2 formation and uptake of four organic micropollutants by carrier-attached microorganisms from two municipal wastewater treatment plants. At the first tier, primary transformation of ibuprofen, naproxen, diclofenac, and mecoprop by carrier-attached microorganisms was shown by the dissipation of the target compounds and the formation of five transformation products using LC-tandem MS. At the second tier, the microbial cleavage of the four organic micropollutants was confirmed with 14 C-labeled micropollutants through liquid scintillation counting of the 14 CO2 formed...
March 16, 2018: Water Research
Peng-Hao Hsu, Din-Chi Chiu, Kuan-Lin Wu, Pei-Shan Lee, Jia-Tsrong Jan, Yih-Shyun E Cheng, Keng-Chang Tsai, Ting-Jen Cheng, Jim-Min Fang
Zanamivir (ZA) and guanidino-oseltamivir carboxylic acid (GOC) are very potent inhibitors against influenza neuraminidase (NA). The guanidinium moiety plays an important role in NA binding; however, its polar cationic nature also hinders the use of ZA and GOC from oral administration. In this study, we investigated the use of ZA and GOC acylguanidine derivatives as possible orally available prodrugs. The acylguanidine derivatives were prepared by coupling with either n-octanoic acid or (S)-naproxen. The lipophilic acyl substituents were verified to improve cell permeability, and may also improve the bioavailability of acylguanidine compounds...
May 21, 2018: European Journal of Medicinal Chemistry
Nadia Umbreen, Saima Sohni, Imtiaz Ahmad, Nimat Ullah Khattak, Kashif Gul
Herein, self-assembled three-dimensional reduced graphene oxide (RGO)-based hydrogels were synthesized and characterized in detail. A thorough investigation on the uptake of three widely used pharmaceutical drugs, viz. Naproxen (NPX), Ibuprofen (IBP) and Diclofenac (DFC) was carried out from aqueous solutions. To ensure the sustainability of developed hydrogel assembly, practically important parameters such as desorption, recyclability and applicability to real samples were also evaluated. Using the developed 3D hydrogels as adsorptive platforms, excellent decontamination for the above mentioned persistent pharmaceutical drugs was achieved in acidic pH with a removal efficiency in the range of 70-80%...
May 14, 2018: Journal of Colloid and Interface Science
Xujun Qiu, Liqiong Lv, Wenyu Sun, Chaoyue Wang, Jizhong Yan, Shengqiang Tong
Three key intermediates in the preparation of the non-steroidal anti-inflammatory drug naproxen were successfully separated and purified with high purity from synthetic mixtures by countercurrent chromatography with a selected biphasic solvent system. The biphasic solvent system composed of n-hexane/ethyl acetate/methanol/water (9:1:9:1, v/v/v/v) was selected according to partition performance of the three components using thin-layer chromatography. 50 mg of the synthetic mixture after the three-step reaction was injected into a preparative countercurrent chromatography separation column and yielded 3...
May 28, 2018: Journal of Separation Science
Siamak Javanbakht, Naser Nazari, Rasul Rakhshaei, Hassan Namazi
In this work, copper acetate was used as a new physical crosslinker to prepare carboxymethylcellulose (CMC) based hydrogel nanocomposite beads. Due to the characteristics of the prepared CMC-based hydrogel nanocomposite beads such as mildness, simplicity, and the creation of small and uniform shapes, the presented procedure could attract great consideration in the field of controlled release of drugs. Naproxen (NPX) as a model drug was pre-loaded during the preparation of hydrogel beads. The prepared Cu-crosslinked carboxymethylcellulose/NPX/graphene quantum dot nanocomposite hydrogel beads (Cu-CMC/NPX/GQD) characterized using FT-IR, Zeta potential, DSC and SEM analysis methods In order to demonstrate the efficiency of the prepared nanocomposite beads as a controlled drug delivery system, the drug delivery tests carried out in the gastrointestinal tract simulated conditions...
September 1, 2018: Carbohydrate Polymers
Xiaomeng Zhang, Ruiying Jing, Xu Feng, Yunyu Dai, Ran Tao, Jan Vymazal, Nan Cai, Yang Yang
To better understand the performance of constructed wetlands (CWs) to remove acidic pharmaceuticals (APs) in wastewaters in subtropical areas and to optimize CW design criteria, six small-scale CWs under different design configurations were operated. The factors (environmental parameters, water quality, and seasonality) influencing the APs removal were also analyzed to illustrate the removal mechanisms. The results indicated that the best performances of CWs were up to 80-90%. Subsurface flow (SSF) CWs showed high removal efficiency for ibuprofen, gemfibrozil and naproxen, but surface flow (SF) CWs performed better for ketoprofen and diclofenac...
May 23, 2018: Science of the Total Environment
Naree Park, Younghun Choi, Deokwon Kim, Kyunghyun Kim, Junho Jeon
Pharmaceuticals and personal care products (PPCPs) in the Yeongsan River, Korea were prioritized via suspect and non-target analysis using LC-HRMS (QExactive plus Orbitrap) followed by semi-quantitative analysis to confirm the priority of PPCPs. A scoring and ranking system for prioritization was suggested based on occurrence frequency and chromatographic peak area or concentration. Through suspect and non-target screening, more than 50 PPCPs were tentatively identified and ranked by the scoring system. Among them, 28 substances were finally confirmed using reference standards...
May 22, 2018: Science of the Total Environment
François Krabansky, Brahim Azzouz, Josette Biya, Malak Abou Taam, Aurore Morel, Thierry Trenque
INTRODUCTION: Eosinophilic pneumonia (EP) is a rare but serious adverse drug reaction (ADR) induced by non-steroidal anti-inflammatory drugs (NSAIDs). METHODS: We describe the second published case of EP induced by oral diclofenac. We also reviewed the literature as well as French pharmacovigilance database. Case presentation A 63 year-old woman with polyarthralgia had taken diclofenac for three days for analgesic purposes. Progressively, the patient presented weakness, dyspnea and fever...
April 28, 2018: Thérapie
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