keyword
MENU ▼
Read by QxMD icon Read
search

Naproxen

keyword
https://www.readbyqxmd.com/read/28223391/evaluation-of-para-aminosalicylic-acid-pas-as-a-substrate-of-multiple-solute-carrier-slc-uptake-transporters-and-possible-drug-interactions-with-nsaids-in-vitro
#1
Md Masud Parvez, Ho Jung Shin, Jin Ah Jung, Jae-Gook Shin
para-Aminosalicylic acid (PAS) is a second-line anti-tuberculosis drug used to treat multidrug-resistant and extensively drug-resistant tuberculosis for more than 60 years. Renal secretion and glomerular filtration are the major pathways for elimination of PAS. We comprehensively studied PAS transport by using cell lines that overexpressed various transporters, and found that PAS acts as a novel substrate of organic anionic polypeptide (OATP1B1), organic cationic transporters (OCT1 and OCT2), and organic anion transporters (OAT1 and OAT3) but not a substrate of any ATP-binding cassette (ABC) transporters...
February 21, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28214729/improved-tolerance-to-transplanting-injury-and-chilling-stress-in-rice-seedlings-treated-with-orysastrobin
#2
Naoto Takahashi, Yukari Sunohara, Masami Fujiwara, Hiroshi Matsumoto
In addition to their fungicidal activity, strobilurin-type fungicides are reported to show enhancing effects on crop growth and yield. Previous studies suggested that the fungicide has a mitigating effect on abiotic stresses. However, there are few reports about growth enhancement through abiotic stress alleviation by strobilurin-type fungicides, but the mechanism of action of the growth enhancement is still not clear. The present study revealed that orysastrobin enhanced rice seedling growth after root cutting injury and chilling stress...
February 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28213140/a-novel-sensor-for-determination-of-naproxen-based-on-change-in-localized-surface-plasmon-peak-of-functionalized-gold-nanoparticles
#3
Javad Khodaveisi, Ali Mohammad Haji Shabani, Shayessteh Dadfarnia, Dariush Saberi
A highly selective and sensitive colorimetric sensor for the determination of naproxen (NAP) based on the aggregation of the thiolated β-cyclodextrin (Tβ-CD) functionalized gold nanoparticles (Tβ-CD-Au NPs) in the presence of NAP and Zn(2+)is described. The hydrophobic end of NAP interacts with the immobilized Tβ-CD on the Au NPs and forms the complex of Tβ-CD:NAP while the Zn(2+) ions form a 1:2 complex of (NAP)2Zn with the carboxyl groups of NAP resulting in the aggregation of functionalized gold nanoparticles...
February 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28199939/sorption-and-desorption-of-selected-non-steroidal-anti-inflammatory-drugs-in-an-agricultural-loam-textured-soil
#4
Y Zhang, G W Price, R Jamieson, D Burton, K Khosravi
Non-steroidal, anti-inflammatory drugs (NSAIDs) are widely used pharmaceutical products with analgesic and anti-inflammatory effects that are consistently detected in municipal wastewater systems and in municipal biosolids. Land application of biosolids and irrigation with reclaimed wastewater introduces these compounds into agricultural environments, which is an emerging issue of concern for ecosystem health. In this study, the sorption-desorption behaviour of four commonly consumed NSAIDs, including naproxen (NPX), ibuprofen (IBU), ketoprofen (KTF), and diclofenac (DCF), was examined in a loam textured soil exposed to either an individual-compound or a mixture of the four NSAIDs...
February 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28199788/development-of-fluorescence-surrogates-to-predict-the-photochemical-transformation-of-pharmaceuticals-in-wastewater-effluents
#5
Shuwen Yan, Bo Yao, Lushi Lian, Xinchen Lu, Shane A Snyder, Rui Li, Weihua Song
The photochemical transformation of pharmaceutical and personal care products (PPCPs) in wastewater effluents is an emerging concern for environmental scientists. In the current study, the photodegradation of 29 PPCPs was examined in effluents under simulated solar irradiation. Direct photodegradation, triplet state effluent organic matter (3EfOM*)-mediated and hydroxyl radical (HO•)-mediated degradation are three major pathways in the removal process. With the photodegradation of trace levels of PPCPs, the excitation-emission matrix (EEM) fluorescence intensities of the effluents were also gradually reduced...
February 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28198617/cometabolic-enzymatic-transformation-of-organic-micropollutants-under-methanogenic-conditions
#6
Lorena Gonzalez-Gil, Marta Carballa, Juan M Lema
Anaerobic digestion (AD) has been shown to have the biological potential to decrease concentrations of several organic micropollutants (OMPs) in sewage sludge. However, the mechanisms and factors behind these biotransformations, which are essential for elucidating the possible transformation products and to foster the complete removal of OMPs via operational strategies, remain unclear. Therefore, this study investigated the transformation mechanisms of 20 OMPs during the methanogenic step of AD with a focus on the role of acetate kinase (AK), which is a key enzyme in methane production...
February 23, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28194990/single-nanochannel-platform-for-detecting-chiral-drugs
#7
Imene Boussouar, Qianjin Chen, Xue Chen, Yulun Zhang, Fan Zhang, Demei Tian, Henry S White, Haibing Li
Chiral drugs play an essential role in medical and biochemical systems, and thus enantioselective analysis of chiral molecules has become a central focus in chemical, biological, medical, and pharmaceutical research. The design of chiral drug-detecting systems is a long-term and challenging task. Here we report the use of a modification-free nanochannel method for enantioselective recognition of S-naproxen from R-naproxen using N-acetyl-l-cysteine-capped gold nanoparticles as a chiral selector. The chiral discrimination is based on a drug-induced nanoparticle diastereoselective aggregation mechanism that blocks ion transport through the nanochannel...
January 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28189026/mass-spectrometry-based-in%C3%A2-vitro-assay-investigations-on-the-transformation-of-pharmaceutical-compounds-by-oxidative-enzymes
#8
Lara F Stadlmair, Thomas Letzel, Jörg E Drewes, Johanna Graßmann
The ubiquitous presence of trace organic chemicals in wastewater and surface water leads to a growing demand for novel removal technologies. The use of isolated enzymes has been shown to possess the capability for a targeted application but requires a clearer mechanistic understanding. In this study, the potential of peroxidase from horseradish (HRP) and laccase from Pleurotus ostreatus (LccPO) to transform selected trace organic chemicals was studied using mass spectrometry (MS)-based in vitro enzyme assays...
February 2, 2017: Chemosphere
https://www.readbyqxmd.com/read/28187918/diazepam-is-no-better-than-placebo-when-added-to-naproxen-for-acute-low-back-pain
#9
Benjamin W Friedman, Eddie Irizarry, Clemencia Solorzano, Nauman Khankel, Jennifer Zapata, Eleftheria Zias, E John Gallagher
STUDY OBJECTIVE: Low back pain causes more than 2.5 million visits to US emergency departments (EDs) annually. Low back pain patients are often treated with nonsteroidal anti-inflammatory drugs and benzodiazepines. The former is an evidence-based intervention, whereas the efficacy of the latter has not been established. We compare pain and functional outcomes 1 week and 3 months after ED discharge among patients randomized to a 1-week course of naproxen+diazepam versus naproxen+placebo...
January 19, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28187390/the-fate-of-pharmaceuticals-and-personal-care-products-ppcps-endocrine-disrupting-contaminants-edcs-metabolites-and-illicit-drugs-in-a-wwtw-and-environmental-waters
#10
Edward Archer, Bruce Petrie, Barbara Kasprzyk-Hordern, Gideon M Wolfaardt
A large number of emerging contaminants (ECs) are known to persist in surface waters, and create pressure on wastewater treatment works (WWTW) for their effective removal. Although a large database for the levels of these pollutants in water systems exist globally, there is still a lack in the correlation of the levels of these pollutants with possible long-term adverse health effects in wildlife and humans, such as endocrine disruption. The current study detected a total of 55 ECs in WWTW influent surface water, 41 ECs in effluent, and 40 ECs in environmental waters located upstream and downstream of the plant...
January 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28177672/a-reappraisal-of-the-6-o-desmethylnaproxen-sulfating-activity-of-the-human-cytosolic-sulfotransferases
#11
Fatemah Alherz, Daniyah A Almarghalani, Noor A Hussein, Katsuhisa Kurogi, Ming-Cheh Liu
In this study, we aimed to obtain a comprehensive account of the human cytosolic sulfotransferases (SULTs) that are capable of sulfating 6-<i>O</i>-desmethylnaproxen (<i>O</i>-DMN), a major metabolite of naproxen. Of the 13 known human SULTs tested, seven, SULT1A1, SULT1A2, SULT1A3, SULT1B1, SULT1C2, SULT1C4, and SULT1E1, displayed <i>O</i>-DMN-sulfating activity, when analyzed using an elevated substrate concentration (500 μM) together with 14 μM of the sulfate donor, 3'-phosphoadenosine-5'-phosphosulfate (PAPS)...
January 22, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28135108/reactive-melt-extrusion-to-improve-the-dissolution-performance-and-physical-stability-of-naproxen-amorphous-solid-dispersions
#12
Xu Liu, Lin Zhou, Feng Zhang
The purpose of this study was to investigate the reaction between naproxen (NPX) and meglumine (MEG) at elevated temperature and to study the effect of this reaction on the physical stabilities and in vitro drug-release properties of melt-extruded naproxen amorphous solid dispersions (ASDs). Differential scanning calorimetry, hot-stage polarized light microscopy, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy analyses demonstrated that in situ salt formation with proton transfer between NPX and MEG occurred at elevated temperature during the melt extrusion process...
January 30, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28127041/therapy-cardiovascular-safety-of-celecoxib-naproxen-and-ibuprofen
#13
Michael T Nurmohamed
No abstract text is available yet for this article.
March 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28126561/hydrophobin-nanofibrillated-cellulose-stabilized-emulsions-for-encapsulation-and-release-of-bcs-class-ii-drugs
#14
Heli Paukkonen, Anni Ukkonen, Geza Szilvay, Marjo Yliperttula, Timo Laaksonen
The purpose of this study was to construct biopolymer-based oil-in-water emulsion formulations for encapsulation and release of poorly water soluble model compounds naproxen and ibuprofen. Class II hydrophobin protein HFBII from Trichoderma reesei was used as a surfactant to stabilize the oil/water interfaces of the emulsion droplets in the continuous aqueous phase. Nanofibrillated cellulose (NFC) was used as a viscosity modifier to further stabilize the emulsions and encapsulate protein coated oil droplets in NFC fiber network...
January 24, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28117757/alkylglycerol-derivatives-a-new-class-of-skin-penetration-modulators
#15
Sergio Alberto Bernal-Chávez, Lilia Yazmín Pérez-Carreto, María Guadalupe Nava-Arzaluz, Adriana Ganem-Rondero
The absorption modulating activity of two alkylglycerol derivatives (batyl and chimyl alcohol) on skin barrier properties was evaluated. Biophysical tests such as transepidermal water loss (TEWL) and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, as well as in vitro skin permeation studies, were performed in order to determine the effect of these compounds as chemical absorption modulators. Four drugs were used as models: three NSAIDS (diclofenac, naproxen, and piroxicam) and glycyrrhizic acid...
January 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28114727/nonsteroidal-anti-inflammatory-drugs-for-pain-in-women-with-endometriosis
#16
REVIEW
Julie Brown, Tineke J Crawford, Claire Allen, Sally Hopewell, Andrew Prentice
BACKGROUND: Endometriosis is a common gynaecological condition that affects women and can lead to painful symptoms and infertility. It greatly affects women's quality of life, impacting their careers, everyday activities, sexual and nonsexual relationships and fertility. Nonsteroidal anti-inflammatory drugs (NSAIDs) are most commonly used as first-line treatment for women with pain associated with endometriosis. OBJECTIVES: To assess effects of NSAIDs used for management of pain in women with endometriosis compared with placebo, other NSAIDs, other pain management drugs or no treatment...
January 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28093585/surface-mounted-mof-templated-fabrication-of-homochiral-polymer-thin-film-for-enantioselective-adsorption-of-drugs
#17
Zhi-Gang Gu, Wen-Qiang Fu, Min Liu, Jian Zhang
A self-polymerized chiral monomer 3,4-dihydroxy-l-phenylalanine (l-DOPA) has been introduced into the pores of an achiral surface-mounted metal organic framework (SURMOF), and then the homochiral poly(l-DOPA) thin film has been successfully formed after UV light irradiation and etching of the SURMOF. Remarkably, such a poly(l-DOPA) thin film exhibited enantioselective adsorption of naproxen. This study opened a SURMOF-templated approach for preparing porous polymer thin films.
January 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28091717/bar-adsorptive-microextraction-technique-application-for-the-determination-of-pharmaceuticals-in-real-matrices
#18
Carlos Almeida, Samir M Ahmad, José Manuel F Nogueira
In the present work, bar adsorptive microextraction using miniaturized devices (7.5 × 3.0 mm) coated with suitable sorbent phases, combined with microliquid desorption (100 μL) followed by high-performance liquid chromatography with diode array detection (BAμE-μLD/HPLC-DAD), is proposed for the determination of trace level of six pharmaceuticals (furosemide, mebeverine, ketoprofen, naproxen, diclofenac and mefenamic acid) in environmental water and urine matrices. By comparing ten distinct sorbent materials (five polymeric and five activated carbons), the polymer P5 proved to be the most suitable to achieve the best selectivity and efficiency...
January 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28074640/evaluation-of-pharmacokinetic-interactions-between-lesinurad-a-new-selective-urate-reabsorption-inhibitor-and-commonly-used-drugs-for-gout-treatment
#19
Zancong Shen, Kathy Tieu, David Wilson, Gail Bucci, Michael Gillen, Caroline Lee, Bradley Kerr
Lesinurad is a novel selective uric acid reabsorption inhibitor approved for treatment of hyperuricemia associated with gout in combination with xanthine oxidase inhibitors (XOIs). Open-label pharmacokinetic studies were performed in volunteers or subjects with hyperuricemia (serum uric acid ≥ 8 mg/dL) to investigate interactions of lesinurad (with and without concurrent XOIs) with colchicine and 2 nonsteroidal anti-inflammatory drugs: naproxen and indomethacin. Colchicine studies included consecutive 7-day treatment periods of (1) allopurinol 300 mg, allopurinol 300 mg plus lesinurad 400 or 600 mg, and continued lesinurad 400 or 600 mg; or (2) febuxostat 40 or 80 mg, febuxostat 40 or 80 mg plus lesinurad 400 mg, and continued febuxostat 40 or 80 mg plus lesinurad 600 mg...
January 11, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28063293/adsorption-of-non-steroidal-anti-inflammatory-drugs-from-aqueous-solution-using-activated-carbons-review
#20
REVIEW
Muthanna J Ahmed
Pharmaceutical pollutants are of significant effect on the environment, so that their treatments have been addressed in many studies. Activated carbon (AC) adsorbent shows best attraction for these compounds due to its unique characteristics represented by high capacity and porosity. In this article, the adsorption performance of AC towards non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, ketoprofen, naproxen, and diclofenac were reviewed. According to collected data, maximum adsorption capacities of 417, 25, 290, and 372 mg/g were obtained from Langmuir isotherm for these drugs, respectively...
April 1, 2017: Journal of Environmental Management
keyword
keyword
28785
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"