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https://www.readbyqxmd.com/read/29149368/dietary-guidance-for-lutein-consideration-for-intake-recommendations-is-scientifically-supported
#1
Katherine M Ranard, Sookyoung Jeon, Emily S Mohn, James C Griffiths, Elizabeth J Johnson, John W Erdman
Lutein, a yellow xanthophyll carotenoid found in egg yolks and many colorful fruits and vegetables, has gained public health interest for its putative role in visual performance and reducing the risk of age-related macular degeneration. The National Academies of Sciences, Engineering and Medicine's recommended Dietary Reference Intakes (DRIs) focus on preventing deficiency and toxicity, but there is a budding interest in establishing DRI-like guidelines for non-essential bioactives, like lutein, that promote optimal health and/or prevent chronic diseases...
November 17, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29148864/morphologic-criteria-of-lesion-activity-in-neovascular-age-related-macular-degeneration-a-consensus-article
#2
Stefania Miotto, Nicola Zemella, Elena Gusson, Giacomo Panozzo, Sandro Saviano, Giuseppe Scarpa, Giorgio Boschi, Stefano Piermarocchi
Intravitreal antivascular endothelial growth factor drugs represent the current standard of care for neovascular age-related macular degeneration (nAMD). Individualized treatment regimens aim at obtaining the same visual benefits of monthly injections with a reduced number of injections and follow-up visits, and, consequently, of treatment burden. The target of these strategies is to timely recognize lesion recurrence, even before visual deterioration. Early detection of lesion activity is critical to ensure that clinical outcomes are not compromised by inappropriate delays in treatment, but questions remain on how to effectively monitor the choroidal neovascularization (CNV) activity...
November 17, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29148527/a-novel-record-for-patients-with-neovascular-age-related-macular-degeneration-providing-information-and-a-personal-treatment-record
#3
M Shah, A M Haque, S M Downes
No abstract text is available yet for this article.
November 17, 2017: Eye
https://www.readbyqxmd.com/read/29148027/sequential-tissue-plasminogen-activator-pneumatic-displacement-and-anti-vegf-treatment-for-submacular-hemorrhage
#4
Handan Bardak, Yavuz Bardak, Yeşim Erçalık, Burak Erdem, Gökhan Arslan, Semrin Timlioglu
PURPOSE: To report the results of our sequential intravitreal (IV) tissue plasminogen activator (tPA), pneumatic displacement (PD), and IV anti-vascular endothelial growth factor (VEGF) treatment in patients with neovascular age-related macular degeneration (nAMD)-related submacular hemorrhage (SMH). METHODS: A total of 16 eyes of 16 patients with SMH of less than 15 days duration were included in this retrospective pilot study. The tPA was applied on the day of diagnosis, and PD was performed the following day...
November 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29147458/erratum-to-nutritional-and-lifestyle-interventions-for-age-related-macular-degeneration-a-review
#5
Ângela Carneiro, José Paulo Andrade
[This corrects the article DOI: 10.1155/2017/6469138.].
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29146756/prevalence-and-factors-associated-with-age-related-macular-degeneration-in-a-southwestern-island-population-of-japan-the-kumejima-study
#6
Ryo Obata, Yasuo Yanagi, Tatsuya Inoue, Miho Yasuda, Yuji Oshima, Shoichi Sawaguchi, Aiko Iwase, Makoto Araie
AIMS: To evaluate the prevalence of and factors associated with age-related macular degeneration (AMD) in a rural population of southwestern Japan. METHODS: This population-based cross-sectional study of all residents aged 40 years or older was conducted on the island of Kumejima, Okinawa, Japan. Of 4632 eligible residents, 3762 completed a comprehensive questionnaire and underwent ocular examination (participant rate, 81.2%). A non-mydriatic fundus photograph was used to grade AMD lesions according to the Wisconsin protocol...
November 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29146306/real-world-vision-in-age-related-macular-degeneration-patients-treated-with-single-anti-vegf-drug-type-for-1-year-in-the-iris-registry
#7
Prethy Rao, Flora Lum, Kevin Wood, Craig Salman, Bhavya Burugapalli, Rebecca Hall, Sukhminder Singh, David W Parke, George A Williams
PURPOSE: The purpose of this study is to compare real-world visual acuity (VA) in patients with neovascular age-related macular degeneration (nAMD) treated with a single anti-vascular endothelial growth factor (VEGF) drug monotherapy for 1 year from the American Academy of Ophthalmology (AAO) Intelligent Research in Sight (IRIS) Registry. DESIGN: Retrospective, nonrandomized, comparative study. PARTICIPANTS: IRIS Registry patients with nAMD who received bevacizumab, ranibizumab, or aflibercept only for 1 year between 2013-2016...
November 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29145690/-visual-analysis-of-retinal-oct-data
#8
Martin Röhlig, Anselm Jünemann, Dagmar-Christiane Fischer, Ruby Kala Prakasam, Oliver Stachs, Heidrun Schumann
Optical coherence tomography (OCT) enables noninvasive high-resolution 3D imaging of the human retina, and thus plays a fundamental role in ophthalmology. Via OCT examination, even subtle retinal changes can be captured, which occur in very early stages of different diseases (e.g., glaucoma, diabetes mellitus, or age-related macular degeneration). Yet, analyzing the resulting data is challenging. Conventionally, OCT data are strongly aggregated via automated methods. While this reduces the amount of information to be analyzed, it also makes it difficult, if not impossible, to identify small and localized retinal changes...
November 16, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29145549/generational-differences-in-the-5-year-incidence-of-age-related-macular-degeneration
#9
Karen J Cruickshanks, David M Nondahl, Lauren J Johnson, Dayna S Dalton, Mary E Fisher, Guan-Hua Huang, Barbara E Klein, Ronald Klein, Carla R Schubert
Importance: Whether a reported decline in the risk of developing age-related macular degeneration (AMD) continued for people born during the Baby Boom years (1946-1964) or later is unknown. These data are important to plan for ocular health care needs in the 21st century. Objectives: To determine whether the 5-year risk for AMD declined by generation and to identify factors that contributed to improvement in risk. Design, Setting, and Participants: Data came from the longitudinal cohort Beaver Dam Eye Study (March 1, 1988, through September 15, 1990, and March 1, 1993, through June 15, 1995) and the Beaver Dam Offspring Study (June 8, 2005, through August 4, 2008, and July 12, 2010, through March 21, 2013)...
November 16, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29143435/risk-factors-for-falls-among-older-aboriginal-and-torres-strait-islander-people-in-urban-and-regional-communities
#10
Caroline Lukaszyk, Kylie Radford, Kim Delbaere, Rebecca Ivers, Kris Rogers, Catherine Sherrington, Anne Tiedemann, Julieann Coombes, Gail Daylight, Brian Draper, Tony Broe
OBJECTIVE: To examine associations between fall risk factors identified previously in other populations and falls among Aboriginal people aged 60 years and older, living in New South Wales, Australia. METHODS: Interviews were conducted with older Aboriginal people in five urban and regional communities. Associations between past falls and 22 fall predictor variables were examined using linear and multiple regression analyses. RESULTS: Of the 336 participants, 80 people (24%) reported at least one fall in the past year, and 34 (10%) reported two or more falls...
November 15, 2017: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/29142592/advances-in-age-related-macular-degeneration-understanding-and-therapy
#11
Joan W Miller, Saghar Bagheri, Demetrios G Vavvas
While the development of anti-vascular endothelial growth factor (anti-VEGF) as a therapy for neovascular age-related macular degeneration (AMD) was a great success, the pathologic processes underlying dry AMD that eventually leads to photoreceptor dysfunction, death, and vision loss remain elusive to date, with a lack of effective therapies and increasing prevalence of the disease. There is an overwhelming need to improve the classification system of AMD, to increase our understanding of cell death mechanisms involved in both neovascular and non-neovascular AMD, and to develop better biomarkers and clinical endpoints to eventually be able to identify better therapeutic targets-especially early in the disease process...
2017: US Ophthalmic Review
https://www.readbyqxmd.com/read/29138977/-reasons-for-delayed-and-discontinued-therapy-in-age-related-macular-degeneration
#12
M W M Wintergerst, J Bouws, J Loss, B Heimes, D Pauleikhoff, F G Holz, R P Finger
BACKGROUND: Critical prerequisites for successful therapy of neovascular age-related macular degeneration (nvAMD) are an early initiation and continuous monitoring; however, delays in starting therapy and non-medically indicated discontinuation of therapy are frequent, which limits therapy efficacy and, thus, visual outcomes. OBJECTIVE: To identify the reasons for delay in therapy and non-medically indicated termination of therapy. MATERIAL AND METHODS: Patients who had started a new therapy (starters) and those who independently terminated therapy (dropouts) were interviewed by telephone with a specific, standardized questionnaire...
November 14, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29138543/location-of-submacular-hemorrhage-as-a-predictor-of-visual-outcome-after-intravitreal-ranibizumab-for-age-related-macular-degeneration
#13
Dimitrios Karagiannis, Irini Chatziralli, Konstantinos Kaprinis, Ilias Georgalas, Efstratios Parikakis, Panagiotis Mitropoulos
Purpose: To evaluate the anatomical and functional outcomes in patients with submacular hemorrhage (SMH) due to age-related macular degeneration (AMD) treated with ranibizumab, and to evaluate the potential role of the SMH location in the final outcome after treatment. Methods: Participants in this study were 12 treatment-naïve patients with SMH due to neovascular AMD who were treated with intravitreal ranibizumab and had at least 12 months' follow-up. All patients underwent best-corrected visual acuity measurement and optical coherence tomography at baseline and at every visit posttreatment, while fluorescein angiography was done at baseline and at the discretion of the physician thereafter...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29137959/moving-from-clinic-to-home-what-the-future-holds-for-ophthalmic-telemedicine
#14
Nancy M Holekamp
PURPOSE: To describe the expanding role of telemedicine in healthcare, the key criteria required for a successful device and program implementation, and the current and future role of home monitoring in ophthalmology. DESIGN: Expert perspective METHODS: Analysis with real-world interpretation of home monitoring technologies including current adoption barriers and expanded future demands based on demographic and market forces. RESULTS: Remote patient monitoring represents a paradigm shift in the way physicians care for patients...
November 11, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29136680/developing-prognostic-biomarkers-in-intermediate-age-related-macular-degeneration-their-clinical-use-in-predicting-progression
#15
REVIEW
Angelica Ly, Michael Yapp, Lisa Nivison-Smith, Nagi Assaad, Michael Hennessy, Michael Kalloniatis
Age-related macular degeneration is a common, complex and blinding eye disease. When early and intermediate levels of severity are detected in one or both eyes, there is a wide-ranging 0.4 to 53 per cent risk of progression to advanced disease in five years. In order to maximise visual outcomes for their patients, practising eye-care professionals must be able to stratify patients according to their risk of progression, intervene (for example by recommending smoking cessation or nutritional supplements and Amsler grid self-monitoring in intermediate disease) and monitor accordingly...
November 14, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29135888/exit-strategy-in-a-treat-and-extend-regimen-for-exudative-age-related-macular-degeneration
#16
Petra Arendt, Siqing Yu, Marion R Munk, Andreas Ebneter, Sebastian Wolf, Martin S Zinkernagel
PURPOSE: To evaluate the outcome of an exit strategy in a treat-and-extend regimen for neovascular age-related macular degeneration. METHODS: Five hundred and ninety-eight eyes of 488 patients with neovascular age-related macular degeneration receiving intravitreal anti-vascular endothelial growth factor injections according to a treat-and-extend regimen were included in this retrospective study. A treat-and-extend regimen with either interval extension by 2 weeks or shortening by 1 week was used...
November 9, 2017: Retina
https://www.readbyqxmd.com/read/29135798/vitrectomy-with-subretinal-tissue-plasminogen-activator-and-gas-tamponade-for-subfoveal-hemorrhage-prognostic-factors-and-clinical-outcomes
#17
David J A Plemel, Steven R J Lapere, Christopher J Rudnisky, Matthew T S Tennant
PURPOSE: To study the prognostic factors and clinical outcomes of patients who underwent pars plana vitrectomy, subretinal injection of tissue plasminogen activator, and gas tamponade for the treatment of subfoveal hemorrhage (SFH). METHODS: A retrospective noncomparative interventional case series. RESULTS: Seventy-eight eyes from 77 patients were included. A total of 84.6% of eyes developed SFH from age-related macular degeneration. Partial or complete displacement of the SFH was achieved in 91...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29135322/retinal-structure-in-pre-clinical-age-related-macular-degeneration
#18
S Nusinowitz, Y Wang, P Kim, S Habib, R Baron, Y Conley, M Gorin
PURPOSE: To determine, if there are identifiable retinal structural changes associated with genetic risk for age-related macular degeneration (AMD). MATERIALS AND METHODS: Seventy-three subjects (range 51.5 to 68.9 years) participated in this prospective study. Subjects were recruited based on the presence of a family history of AMD in one or both parents. All participants underwent a complete ophthalmic exam and imagery for staging of disease severity and genetic testing to assess genetic risk for AMD development...
November 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29133669/severe-gemella-haemolysans-endophthalmitis-following-ranibizumab-intravitreal-injection
#19
Silvia Olivia Salceanu, Sarah Levy, Richard Cunningham, Kwabena Frimpong-Ansah
Gemella haemolysans is a commensal of the upper respiratory tract that is rarely involved in ocular pathology. We present a unique case of endophthalmitis with negative cultures and positive 16s ribosomal ribonucleic acid gene sequencing showing G. haemolysans infection after an intravitreal ranibizumab injection for wet age-related macular degeneration.
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133652/hospital-anxiety-and-depression-scale-assessment-of-100-patients-before-and-after-using-low-vision-care-a-prospective-study-in-a-tertiary-eye-care-setting
#20
Pukhraj Rishi, Ekta Rishi, Aditya Maitray, Ashutosh Agarwal, Sridevi Nair, Sarika Gopalakrishnan
PURPOSE: Assessment of anxiety and depression in patients attending low vision care (LVC) using Hospital Anxiety and Depression Scale (HADS). METHODS: In this prospective, observational study, 100 patients with best-corrected visual acuity (BCVA) worse than 6/18 in the better eye or limitation of field of vision to <10° from center of fixation were assessed on the depression and anxiety subscales of HADS questionnaire before and after LVC. HADS is a 14-item scale with seven items each for anxiety and depression subscales...
November 2017: Indian Journal of Ophthalmology
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