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https://www.readbyqxmd.com/read/29667718/trajectories-of-psychopathology-in-extremely-low-birth-weight-survivors-from-early-adolescence-to-adulthood-a-20-year-longitudinal-study
#1
Ryan J Van Lieshout, Mark A Ferro, Louis A Schmidt, Michael H Boyle, Saroj Saigal, Katherine M Morrison, Karen J Mathewson
BACKGROUND: Individuals born extremely preterm are exposed to significant perinatal stresses that are associated with an increased risk of psychopathology. However, a paucity of longitudinal studies has prevented the empirical examination of long-term, dynamic effects of perinatal adversity on mental health. Here, internalizing and externalizing problems from adolescence through adulthood were compared in individuals born at extremely low birth weight (ELBW; <1,000 g) and normal birth weight (NBW; >2,500 g)...
April 18, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29667634/-the-dynamics-of-the-dimensional-characteristics-of-the-sella-turcica-in-the-subjects-above-20-years-of-age
#2
Yu I Pigolkin, M D Ametrin, G V Zolotenkova
The objective of the present study was to determine the biological age of the unidentified dead subjects based on the morphometric characteristics of the sella turcica in comparison with other methods available for the purpose in order to narrow the range of the alleged ages of the human remains being examined. The parameters of the sella turcica were measured in the corpses immediately after cephalotomy provided no pathological changes could be identified in the sellar region. A total of 86 skulls of the Caucasoid subjects representing the Eastern-Slavic group at the age varying from 22 to 87 years were available for the examination...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29666799/comparison-of-two-major-staging-systems-of-esophageal-cancer-toward-more-practical-common-scale-for-tumor-staging
#3
REVIEW
Harushi Udagawa, Masaki Ueno
The latest 8th edition of TNM Classification of Malignant Tumours by Union for International Cancer Control (UICC) and 11th edition of Japanese Classification of Esophageal Cancer by Japan Esophageal Society (JES) are the two major classifications widely accepted as tools for clinical staging of esophageal cancer. Both systems consist of three main categories, i.e., T, N, and M, but large difference exists between the two. JES system has more detailed sub-classification of T1 tumors reflecting meticulous work by Japanese investigators on superficial esophageal cancer...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666567/the-neural-correlates-of-grasping-in-left-handers-when-handedness-does-not-matter
#4
Chiara Begliomini, Luisa Sartori, Maria G Di Bono, Sanja Budisavljević, Umberto Castiello
Neurophysiological studies showed that in macaques, grasp-related visuomotor transformations are supported by a circuit involving the anterior part of the intraparietal sulcus, the ventral and the dorsal region of the premotor area. In humans, a similar grasp-related circuit has been revealed by means of neuroimaging techniques. However, the majority of "human" studies considered movements performed by right-handers only, leaving open the question of whether the dynamics underlying motor control during grasping is simply reversed in left-handers with respect to right-handers or not...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29666565/postnatal-vitamin-d-intake-modulates-hippocampal-learning-and-memory-in-adult-mice
#5
Qiujuan Liang, Chunhui Cai, Dongxia Duan, Xinyu Hu, Wanhao Hua, Peicheng Jiang, Liu Zhang, Jun Xu, Zhengliang Gao
Vitamin D (VD) is a neuroactive steroid crucial for brain development, function and homeostasis. Its deficiency is associated with numerous brain conditions. As such, VD and its variants are routinely taken by a broad of groups with/without known VD deficiency. In contrast, the harmful effects of VD overdose have been poorly studied. Similarly, the developmental stage-specific VD deficiency and overdose have been rarely explored. In the present work, we showed that postnatal VD supplementation enhanced the motor function transiently in the young adult, but not in the older one...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29666158/qc-art-a-tool-for-real-time-quality-control-assessment-of-mass-spectrometry-based-proteomics-data
#6
Bryan A Stanfill, Ernesto S Nakayasu, Lisa M Bramer, Allison M Thompson, Charles K Ansong, Therese Clauss, Marina A Gritsenko, Matthew E Monroe, Ronald J Moore, Daniel J Orton, Paul D Piehowski, Athena A Schepmoes, Richard D Smith, Bobbie-Jo Webb-Robertson, Thomas O Metz, The Environmental Determinants Of Diabetes In The Young Teddy Study Group
Liquid chromatography-mass spectrometry (LC-MS)-based proteomics studies of large sample cohorts can easily require from months to years to complete. Acquiring consistent, high-quality data in such large-scale studies is challenging because of normal variations in instrumentation performance over time, as well as artifacts introduced by the samples themselves, such as those due to collection, storage and processing. Existing quality control methods for proteomics data primarily focus on post-hoc analysis to remove low-quality data that would degrade downstream statistics; they are not designed to evaluate the data in near real-time, which would allow for interventions as soon as deviations in data quality are detected...
April 17, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29665962/the-degradation-of-three-ringed-polycyclic-aromatic-hydrocarbons-by-wood-inhabiting-fungus-pleurotus-ostreatus-and-soil-inhabiting-fungus-agaricus-bisporus
#7
Natalia Pozdnyakova, Ekaterina Dubrovskaya, Marina Chernyshova, Oleg Makarov, Sergey Golubev, Svetlana Balandina, Olga Turkovskaya
The degradation of two isomeric three-ringed polycyclic aromatic hydrocarbons by the white rot fungus Pleurotus ostreatus D1 and the litter-decomposing fungus Agaricus bisporus F-8 was studied. Despite some differences, the degradation of phenanthrene and anthracene followed the same scheme, forming quinone metabolites at the first stage. The further fate of these metabolites was determined by the composition of the ligninolytic enzyme complexes of the fungi. The quinone metabolites of phenanthrene and anthracene produced in the presence of only laccase were observed to accumulate, whereas those formed in presence of laccase and versatile peroxidase were metabolized further to form products that were further included in basal metabolism (e...
May 2018: Fungal Biology
https://www.readbyqxmd.com/read/29664750/head-movements-allow-listeners-bilaterally-implanted-with-cochlear-implants-to-resolve-front-back-confusions
#8
M Torben Pastore, Sarah J Natale, William A Yost, Michael F Dorman
OBJECTIVES: We report on the ability of patients fit with bilateral cochlear implants (CIs) to distinguish the front-back location of sound sources both with and without head movements. At issue was (i) whether CI patients are more prone to front-back confusions than normal hearing listeners for wideband, high-frequency stimuli; and (ii) if CI patients can utilize dynamic binaural difference cues, in tandem with their own head rotation, to resolve these front-back confusions. Front-back confusions offer a binary metric to gain insight into CI patients' ability to localize sound sources under dynamic conditions not generally measured in laboratory settings where both the sound source and patient are static...
April 16, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29664630/lysine-side-chain-dynamics-in-the-binding-site-of-homeodomain-dna-complexes-as-observed-by-nmr-relaxation-experiments-and-molecular-dynamics-simulations
#9
Jamie M Baird-Titus, Mahendra Thapa, Thomas Doerdelmann, Kelly A Combs, Mark Rance
An important but poorly characterized contribution to the thermodynamics of protein-DNA interactions is the loss of entropy that occurs from restricting the conformational freedom of amino acid side chains. The effect of restricting the flexibility of several side chains at a protein-DNA interface may be comparable in many cases to the other factors that determine the binding thermodynamics, and may therefore play a key role in dictating the binding affinity and/or specificity. Because the entropic contributions, including the presence and influence of side-chain dynamics, are especially difficult to estimate based on structural information, it is important to pursue experimental and theoretical studies that can provide direct information regarding these issues...
April 17, 2018: Biochemistry
https://www.readbyqxmd.com/read/29664323/understanding-the-interaction-between-oligopeptide-and-water-in-aqueous-solution-using-temperature-dependent-near-infrared-spectroscopy
#10
Dan Cheng, Wensheng Cai, Xueguang Shao
Investigating the interaction between oligopeptide and water is essential for understanding the structure, dynamics and function of proteins. Temperature-dependent near-infrared (NIR) spectroscopy and independent component analysis (ICA) were employed to study the interaction between oligopeptide and water in aqueous solution. The NIR spectra of two homo-oligopeptides, penta-aspartic acid (D5 ) and penta-lysine (K5 ), in aqueous solution of different concentration were measured at different temperature (30-90 ℃)...
January 1, 2018: Applied Spectroscopy
https://www.readbyqxmd.com/read/29664285/core-shell-au-metal-organic-framework-for-promoting-raman-detection-sensitivity-of-methenamine
#11
Yanzheng Cai, Yiping Wu, Tong Xuan, Xiaoyu Guo, Ying Wen, Hai-Feng Yang
Abuse of methenamine in foodstuff is harmful to the health of people. Routine methods recommended by national standard are indirect assay with complicated pretreatment of sample or less sensitivity. In this work, core-shell Au nanoparticles@inositol hexaphosphate@MIL-101(Fe) nanoparticles, designated as Au@MIL-101, are successfully synthesized by layer-by-layer assembly. Metal-organic framework (MOF, MIL-101) modified AuNPs could narrow the distance between neighboring Au@MIL-101, which increases the amount of "hot spots and contributes excellent enhancement of Raman scattering...
April 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29663856/computational-insights-into-the-interaction-of-small-molecule-inhibitors-with-hri-kinase-domain
#12
Sourabh Palrecha, Dushant Lakade, Abhijeet Kulkarni, Jayanta K Pal, Manali Joshi
The heme-regulated inhibitor (HRI) kinase regulates globin synthesis in a heme-dependent manner in reticulocytes and erythroid cells in bone marrow. Inhibitors of HRI have been proposed to lead to an increased amount of hemoglobin, benefitting anemia patients. A series of indeno[1,2-c]pyrazoles were discovered to be the first known in vitro inhibitors of HRI. However, the structural mechanism of inhibition is yet to be understood. The aim of this study was to unravel the binding mechanism of these inhibitors using molecular dynamic simulations and docking...
April 17, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29663411/breast-cancer-mri-radiomics-an-overview-of-algorithmic-features-and-impact-of-inter-reader-variability-in-annotating-tumors
#13
Ashirbani Saha, Michael R Harowicz, Maciej A Mazurowski
PURPOSE: To review features used in MRI radiomics of breast cancer and study the inter-reader stability of the features METHODS: We implemented 529 algorithmic features that can be extracted from tumor and fibroglandular tissue (FGT) in breast MRIs. The features were identified based on a review of the existing literature with consideration of their usage, prognostic ability, and uniqueness. The set was then extended so that it comprehensively describes breast cancer imaging characteristics...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29663393/maternal-obesity-reprograms-offspring-s-executive-brain-centers-in-a-sex-specific-manner-an-editorial-for-perinatal-high-fat-diet-and-early-life-methyl-donor-supplementation-alter-one-carbon-metabolism-and-dna-methylation-in-the-brain-on-doi-10-1111-jnc-14319
#14
EDITORIAL
Kaja Plucińska, Steven W Barger
This editorial highlights an article by McKee and colleagues in the current issue of Journal of Neurochemistry, in which the authors report epigenetic changes linked to one-carbon metabolism in prefrontal cortex (PFC) of murine offspring from dams fed high-fat diet to mimic maternal obesity. The group found that high-fat diet feeding in utero increases weight gain in offspring and dynamically alters DNA methylation in the PFC of male but not female brains. These epigenetic marks were associated with a shift in brain one-carbon metabolism (folate and methionine) intermediates and were normalized by early-life methyl-donor supplementation in a sex-specific manner...
April 16, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29663353/positron-emission-tomography-imaging-of-cerebral-glucose-metabolism-and-type-1-cannabinoid-receptor-availability-during-temporal-lobe-epileptogenesis-in-the-amygdala-kindling-model-in-rhesus-monkeys
#15
Evy Cleeren, Cindy Casteels, Karolien Goffin, Michel Koole, Koen Van Laere, Peter Janssen, Wim Van Paesschen
OBJECTIVE: We investigated changes in the endocannabinoid system and glucose metabolism during temporal lobe epileptogenesis. METHODS: Because it is rarely possible to study epileptogenesis in humans, we applied the electrical amygdala kindling model in nonhuman primates to image longitudinal changes in type 1 cannabinoid receptor (CB1R) binding and cerebral glucose metabolism. Two rhesus monkeys received [18 F]-MK-9470 and fluorodeoxyglucose-positron emission tomography ([18 F]-FDG -PET) scans in each of the 4 kindling stages to quantify relative changes over time of CB1R binding and cerebral glucose metabolism in vivo...
April 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29663178/validation-of-contrast-enhanced-time-resolved-magnetic-resonance-angiography-in-pre-ablation-planning-in-patients-with-atrial-fibrillation-comparison-with-traditional-technique
#16
Tarek Zghaib, Adeel Shahid, Chiara Pozzessere, Kristin K Porter, Linda C Chu, John Eng, Hugh Calkins, Ihab R Kamel, Saman Nazarian, Stefan L Zimmerman
Bolus timing is critical to optimal magnetic resonance angiography (MRA) acquisitions but can be challenging in some patients. Our purpose was to evaluate whether contrast-enhanced time-resolved magnetic resonance angiography (TR-MRA), a dynamic multiphase sequence that does not rely on bolus timing, is a viable alternative method to conventional 3D fast-long angle shot contrast-enhanced magnetic resonance angiography (CE-MRA). Coronal subtracted conventional CE-MRA images in 50 consecutive patients presenting for pre-atrial fibrillation ablation pulmonary venous (PV) mapping were compared with 50 TR-MRA images performed in 50 subsequent patients...
April 16, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29662767/reconstruction-of-the-lateral-tibia-plateau-fracture-with-a-third-triangular-support-screw-a-biomechanical-study
#17
Eduardo Moran, Ivan Zderic, Kajetan Klos, Paul Simons, Miguel Triana, R Geoff Richards, Boyko Gueorguiev, Mark Lenz
Background: Split fractures of the lateral tibia plateau in young patients with good bone quality are commonly treated using two minimally invasive percutaneous lag screws, followed by unloading of the knee joint. Improved stability could be achieved with the use of a third screw inserted either in the jail-technique fashion or with a triangular support screw configuration. The aim of this study was to investigate under cyclic loading the compliance and endurance of the triangular support fixation in comparison with the standard two lag-screw fixation and the jail technique...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662766/clinical-validation-of-a-body-fixed-3d-accelerometer-and-algorithm-for-activity-monitoring-in-orthopaedic-patients
#18
Matthijs Lipperts, Simon van Laarhoven, Rachel Senden, Ide Heyligers, Bernd Grimm
Background/Objective: Activity is increasingly being recognized as a highly relevant parameter in all areas of healthcare for diagnosis, treatment, or outcome assessment, especially in orthopaedics where the movement apparatus is directly affected. Therefore, the aim of this study was to develop, describe, and clinically validate a generic activity-monitoring algorithm, satisfying a combination of three criteria. The algorithm must be able to identify, count, and time a large set of relevant daily activities...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662758/neutrophil-to-lymphocyte-ratio-shows-faster-changing-kinetics-than-c-reactive-protein-after-total-hip-and-knee-arthroplasty
#19
Marcin Krzysztof Wasko, Marek Struminski, Konstancja Bobecka-Wesolowska, Jacek Kowalczewski
Background: Total hip arthroplasty (THA) and total knee arthroplasty (TKA) induce inflammatory reactions, which can be described by changes in the neuroendocrine, cellular, protein, and cytokine systems. The aim of this study was to document the normal distribution pattern of the neutrophil-to-lymphocyte ratio (NLR) after THA and TKA and to compare it with postoperative C-reactive protein (CRP) patterns. Methods: Changes in serum CRP levels, neutrophil count, and lymphocyte count were measured before and during the first 5 postoperative days in a prospective study performed on 387 patients undergoing total hip or knee arthroplasty...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662506/patterns-of-in-hospital-mortality-and-bleeding-complications-following-pci-for-very-elderly-patients-insights-from-the-dartmouth-dynamic-registry
#20
Shawn X Li, Hannah I Chaudry, Jiyong Lee, Theodore B Curran, Vishesh Kumar, Kendrew K Wong, Bruce W Andrus, James T DeVries
Background: Very elderly patients (age ≥ 85 years) are a rapidly increasing segment of the population. As a group, they experience high rates of in-hospital mortality and bleeding complications following percutaneous coronary intervention (PCI). However, the relationship between bleeding and mortality in the very elderly is unknown. Methods: Retrospective review was performed on 17,378 consecutive PCI procedures from 2000 to 2015 at Dartmouth-Hitchcock Medical Center...
February 2018: Journal of Geriatric Cardiology: JGC
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