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JOURNAL ARTICLE
Leandro Jofré
In 1930, Melanie Klein published an article presenting the case of Dick. Within the framework of the psychoanalytic technique adapted to the clinical treatment of autism, this article contributes elements to a question posed by many psychoanalysts: why did Klein's interventions affect Dick? To that end, Klein's first intervention is divided into two phases: a first naming phase, consented to by Dick; and a second interpretation phase, triggering detachment from the object, anxiety, and stereotypy. The proposal is to understand the emergence of anxiety in the relationship that the second-phase interpretation has with the first phase of naming...
August 24, 2023: Psychoanalytic Quarterly
#22
JOURNAL ARTICLE
Felice Cinque, Sahar Saeed, Dana Kablawi, Luz Ramos Ballesteros, Wesal Elgretli, Erica E M Moodie, Colleen Price, Ken Monteith, Curtis Cooper, Sharon L Walmsley, Neora Pick, Melanie C M Murray, Joseph Cox, Nadine Kronfli, Cecilia T Costiniuk, Alexandra de Pokomandy, Jean-Pierre Routy, Bertrand Lebouché, Marina B Klein, Giada Sebastiani
INTRODUCTION: Advanced chronic liver disease (ACLD) is a major cause of death for people with HIV (PWH). While viral hepatitis coinfections are largely responsible for this trend, metabolic dysfunction-associated steatotic liver disease (MASLD) is an emerging concern for PWH. We aimed to assess the contribution of MASLD to incident ACLD in PWH. METHODS AND ANALYSIS: This multicentre prospective observational cohort study will enrol 968 consecutive HIV monoinfected patients from four Canadian sites, excluding subjects with alcohol abuse, liver disease other than MASLD, or ACLD at baseline...
August 22, 2023: BMJ Open
#23
JOURNAL ARTICLE
Oliver Riedel, M Braitmaier, Mark Dankhoff, Michel Hornschuch, Melanie Klein, Wiebke Zachariassen, Jana Hoyer
BACKGROUND: Bariatric interventions (BI, including surgical interventions) are effective in patients with massive obesity, i.e., a body mass index (BMI) > 40, and their number has steadily increased during the past decade. Yet, the stability of improvements in quality of life (QoL) in post-interventional patients is understudied and restricted to studies with small samples and short follow-ups. METHODS: Patients with BI between 2004 and 2018 were identified in a health claims database and invited to fill in a survey, comprising sociodemographic and lifestyle information and psychometric scales...
2023: Obesity Research & Clinical Practice
#24
JOURNAL ARTICLE
Steffi Treitschke, Kathrin Weidele, Adithi Ravikumar Varadarajan, Giancarlo Feliciello, Jens Warfsmann, Sybille Vorbeck, Bernhard Polzer, Catherine Botteron, Martin Hoffmann, Vadim Dechand, Tobias Mederer, Florian Weber, Melanie Werner-Klein, Tobias Robold, Hans-Stefan Hofmann, Christian Werno, Christoph A Klein
The cellular basis of the apparent aggressiveness in lung cancer is poorly understood but likely associated with functional or molecular features of disseminated cancer cells (DCCs). DCCs from epithelial cancers are mostly detected by antibodies directed against histogenetic markers such as cytokeratin or EpCAM. It has been argued that marker-negative metastatic founder cells might escape detection. We therefore used ex vivo sphere formation for functional detection of candidate metastasis founders. We generated cell suspensions from 199 LN samples of 131 lung cancer patients and placed them into non-adherent cell culture...
August 9, 2023: International Journal of Cancer. Journal International du Cancer
#25
JOURNAL ARTICLE
Astrid Ruiz-Margáin, Alessandra Pohlmann, Silke Lanzerath, Melanie Langheinrich, Alejandro Campos-Murguía, Berenice M Román-Calleja, Robert Schierwagen, Sabine Klein, Frank Erhard Uschner, Maximilian Joseph Brol, Aldo Torre-Delgadillo, Nayelli C Flores-García, Michael Praktiknjo, Ricardo U Macías Rodríguez, Jonel Trebicka
BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) has been linked to different pathophysiological mechanisms, including systemic inflammation and mitochondrial dysfunction. Sarcopenia has also been proposed as a potential mechanism; myostatin is a key factor inducing sarcopenia. Therefore, this study aimed to evaluate the association of myostatin levels with the development of ACLF and mortality in patients with cirrhosis. METHODS: We performed a prospective cohort study, including both outpatient and hospitalized patients with cirrhosis...
August 2023: JHEP reports: innovation in hepatology
#26
JOURNAL ARTICLE
Berit Lange, Veronika K Jaeger, Manuela Harries, Viktoria Rücker, Hendrik Streeck, Sabine Blaschke, Astrid Petersmann, Nicole Toepfner, Matthias Nauck, Max J Hassenstein, Maren Dreier, Isabell von Holt, Axel Budde, Antonia Bartz, Julia Ortmann, Marc-André Kurosinski, Reinhard Berner, Max Borsche, Gunnar Brandhorst, Melanie Brinkmann, Kathrin Budde, Marek Deckena, Geraldine Engels, Marc Fenzlaff, Christoph Härtel, Olga Hovardovska, Alexander Katalinic, Katja Kehl, Mirjam Kohls, Stefan Krüger, Wolfgang Lieb, Kristin M Meyer-Schlinkmann, Tobias Pischon, Daniel Rosenkranz, Nicole Rübsamen, Jan Rupp, Christian Schäfer, Mario Schattschneider, Anne Schlegtendal, Simon Schlinkert, Lena Schmidbauer, Kai Schulze-Wundling, Stefan Störk, Carsten Tiemann, Henry Völzke, Theresa Winter, Christine Klein, Johannes Liese, Folke Brinkmann, Patrick F Ottensmeyer, Jens-Peter Reese, Peter Heuschmann, André Karch
PURPOSE: Despite the need to generate valid and reliable estimates of protection levels against SARS-CoV-2 infection and severe course of COVID-19 for the German population in summer 2022, there was a lack of systematically collected population-based data allowing for the assessment of the protection level in real time. METHODS: In the IMMUNEBRIDGE project, we harmonised data and biosamples for nine population-/hospital-based studies (total number of participants n = 33,637) to provide estimates for protection levels against SARS-CoV-2 infection and severe COVID-19 between June and November 2022...
August 2, 2023: Infection
#27
REVIEW
Melanie Machiels, Redouane Oulkadi, Trine Tramm, Shane R Stecklein, Navita Somaiah, Alex De Caluwé, Jonathan Klein, William T Tran, Roberto Salgado
Radiation therapy (RT) has long been fundamental for the curative treatment of breast cancer. While substantial progress has been made in the anatomical and technological precision of RT delivery, and some approaches to de-escalate or omit RT based on clinicopathologic features have been successful, there remain substantial opportunities to refine individualised RT based on tumour biology. A major area of clinical and research interest is to ascertain the individualised risk of loco-regional recurrence to direct treatment decisions regarding escalation and de-escalation of RT...
July 1, 2023: Breast: Official Journal of the European Society of Mastology
#28
JOURNAL ARTICLE
Massimo Saini, Laura Schmidleitner, Helena Domínguez Moreno, Elisa Donato, Mattia Falcone, Johanna M Bartsch, Vanessa Vogel, Roberto Würth, Nicole Pfarr, Elisa Espinet, Mareike Lehmann, Melanie Königshoff, Manuel Reitberger, Simon Haas, Elisabeth Graf, Thomas Schwarzmayr, Tim-Matthias Strom, Saskia Spaich, Marc Sütterlin, Andreas Schneeweiss, Wilko Weichert, Gunnar Schotta, Maximilian Reichert, Nicola Aceto, Martin R Sprick, Andreas Trumpp, Christina H Scheel, Corinna Klein
The acquisition of mesenchymal traits is considered a hallmark of breast cancer progression. However, the functional relevance of epithelial-to-mesenchymal transition (EMT) remains controversial and context dependent. Here, we isolate epithelial and mesenchymal populations from human breast cancer metastatic biopsies and assess their functional potential in vivo. Strikingly, progressively decreasing epithelial cell adhesion molecule (EPCAM) levels correlate with declining disease propagation. Mechanistically, we find that persistent EPCAM expression marks epithelial clones that resist EMT induction and propagate competitively...
May 30, 2023: Cell Reports
#29
JOURNAL ARTICLE
Florian Märkl, Mohamed-Reda Benmebarek, Julius Keyl, Bruno L Cadilha, Martina Geiger, Clara Karches, Hannah Obeck, Melanie Schwerdtfeger, Stefanos Michaelides, Daria Briukhovetska, Sophia Stock, Jakob Jobst, Philipp Jie Müller, Lina Majed, Matthias Seifert, Anna-Kristina Klüver, Theo Lorenzini, Ruth Grünmeier, Moritz Thomas, Adrian Gottschlich, Richard Klaus, Carsten Marr, Michael von Bergwelt-Baildon, Simon Rothenfusser, Mitchell P Levesque, Markus Vincent Heppt, Stefan Endres, Christian Klein, Sebastian Kobold
BACKGROUND: Melanoma is an immune sensitive disease, as demonstrated by the activity of immune check point blockade (ICB), but many patients will either not respond or relapse. More recently, tumor infiltrating lymphocyte (TIL) therapy has shown promising efficacy in melanoma treatment after ICB failure, indicating the potential of cellular therapies. However, TIL treatment comes with manufacturing limitations, product heterogeneity, as well as toxicity problems, due to the transfer of a large number of phenotypically diverse T cells...
May 2023: Journal for Immunotherapy of Cancer
#30
JOURNAL ARTICLE
Dominic Angeloch
In the dream and its interpretation, psychoanalysis, in its founding period around 1900, identified the "royal road to a knowledge of the unconscious in the psychic life." But already in the development of Freud's work itself, the dream lost its central position: As early as in the 1920s, psychoanalysis ceased to be a theory and practice defined by dream interpretation-a caesura in a process which completed itself in 1950. Two further developments proved, up to the present day, particularly momentous for the conception of the dream: Melanie Klein's development of the concept of "unconscious phantasy" and the extension of psychoanalytic treatment to psychosis, originally declared inaccessible to psychoanalytic therapy by Freud...
May 9, 2023: American Journal of Psychoanalysis
#31
JOURNAL ARTICLE
Rachel B Blass
In this paper the author offers a new reading of Freud's "Remembering, Repeating and Working-through", examining the complex nature of central concepts that Freud presents within it. She demonstrates the text's special role in an ongoing effort of Freud's to articulate and ground the heart of his analytic insight that knowledge cures. While the insight itself is very well-known, the fact that Freud struggled throughout his life with its articulation and grounding is not. The struggle centered on questions pertaining to how analytic knowing could, not only enlighten the patient, but actually change his unconscious dynamics, and why the patient, having already "opted" for pathology in place of knowing would come to accept it; and ultimately, what was the nature of the knowledge offered in analysis and the individual's relationship to it that allowed for such dramatic changes to occur...
May 5, 2023: International Journal of Psycho-analysis
#32
JOURNAL ARTICLE
Leigh L Smith, Susan A Fallon, Zunaira Q Virk, Alejandra B Salinas, Melanie S Curless, Sara E Cosgrove, Lisa L Maragakis, Clare Rock, Eili Y Klein
Exposure investigations are labor intensive and vulnerable to recall bias. We developed an algorithm to identify healthcare personnel (HCP) interactions from the electronic health record (EHR), and we evaluated its accuracy against conventional exposure investigations. The EHR algorithm identified every known transmission and used ranking to produce a manageable contact list.
April 28, 2023: Infection Control and Hospital Epidemiology
#33
JOURNAL ARTICLE
Melanie Au, Ellie Coombs, Andrew Jones, Frances Carley, Maya Talwar-Hebert, West Addison, Robert J Mills, Stacy M Cohen, Pamela W Klein, Laura Cheever, Boyd Gilman
As people with HIV increasingly access affordable health care coverage-enabling them to obtain medical care from private providers-understanding how they use the Ryan White HIV/AIDS Program (RWHAP), and their unmet health care needs, can enhance their overall care. We analyzed RWHAP client-level data and interviewed staff and clients at 29 provider organizations to identify trends in health care coverage and service use for clients who received medical care from private providers. The RWHAP helps cover the cost of premiums and copays for these clients and provides medical and support services that help them stay engaged in care and virally suppressed...
April 20, 2023: Journal of the Association of Nurses in AIDS Care: JANAC
#34
JOURNAL ARTICLE
Lydia Reinhardt, Fabrizio Musacchio, Maria Bichmann, Annika Behrendt, Ebru Ercan-Herbst, Juliane Stein, Isabelle Becher, Per Haberkant, Julia Mader, David C Schöndorf, Melanie Schmitt, Jürgen Korffmann, Peter Reinhardt, Christian Pohl, Mikhail Savitski, Corinna Klein, Laura Gasparini, Martin Fuhrmann, Dagmar E Ehrnhoefer
Intraneuronal aggregates of the microtubule binding protein Tau are a hallmark of different neurodegenerative diseases including Alzheimer's disease (AD). In these aggregates, Tau is modified by posttranslational modifications such as phosphorylation as well as by proteolytic cleavage. Here we identify a novel Tau cleavage site at aspartate 65 (D65) that is specific for caspase-2. In addition, we show that the previously described cleavage site at D421 is also efficiently processed by caspase-2, and both sites are cleaved in human brain samples...
April 20, 2023: Neurobiology of Disease
#35
JOURNAL ARTICLE
Merav Roth
Working through the different faces and vicissitudes of the death drive in the countertransference, and especially through projective identification, is a very challenging process. A thorough and versatile process of containment and working through of the manifold threatening expressions and influences of the death drive is required, experienced most specifically and deeply in the arena of projective identification. This paper demonstrates how each aspect that unfolds in the analyst's countertransference sheds light on a particular layer of anxiety and internal object relations related to it...
March 2023: Psychoanalytic Review
#36
REVIEW
Giulio de Felice, Nihal Tutal
This paper analyses two opposite relational configurations: violence and the capacity to hate. The former results in a psychic impoverishment, the latter in a psychic development. Primarily, the aspects of violence and the inability to hate within modern Western society are introduced. When a psychic fragility is unconsciously supported by an entire society, it becomes even more difficult to alleviate, and transform into a resource promoting psychic development. The second section explores the use of hate by young children in order to show the naturalness of this emotion and its origin...
February 15, 2023: Healthcare (Basel, Switzerland)
#37
REVIEW
Edina M Klein, Melanie T Knoll, Johannes Gescher
Microbial electrochemical systems (MESs) are a highly versatile platform technology with a particular focus on power or energy production. Often, they are used in combination with substrate conversion (e.g., wastewater treatment) and production of value-added compounds via electrode-assisted fermentation. This rapidly evolving field has seen great improvements both technically and biologically, but this interdisciplinarity sometimes hampers overseeing strategies to increase process efficiency. In this review, we first briefly summarize the terminology of the technology and outline the biological background that is essential for understanding and thus improving MES technology...
February 18, 2023: Microbial Biotechnology
#38
JOURNAL ARTICLE
Björn-Erik Ole Jensen, Elena Knops, Leon Cords, Nadine Lübke, Maria Salgado, Kathleen Busman-Sahay, Jacob D Estes, Laura E P Huyveneers, Federico Perdomo-Celis, Melanie Wittner, Cristina Gálvez, Christiane Mummert, Caroline Passaes, Johanna M Eberhard, Carsten Münk, Ilona Hauber, Joachim Hauber, Eva Heger, Jozefien De Clercq, Linos Vandekerckhove, Silke Bergmann, Gábor A Dunay, Florian Klein, Dieter Häussinger, Johannes C Fischer, Kathrin Nachtkamp, Joerg Timm, Rolf Kaiser, Thomas Harrer, Tom Luedde, Monique Nijhuis, Asier Sáez-Cirión, Julian Schulze Zur Wiesch, Annemarie M J Wensing, Javier Martinez-Picado, Guido Kobbe
Despite scientific evidence originating from two patients published to date that CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human immunodeficiency virus type 1 (HIV-1), the knowledge of immunological and virological correlates of cure is limited. Here we characterize a case of long-term HIV-1 remission of a 53-year-old male who was carefully monitored for more than 9 years after allogeneic CCR5Δ32/Δ32 HSCT performed for acute myeloid leukemia. Despite sporadic traces of HIV-1 DNA detected by droplet digital PCR and in situ hybridization assays in peripheral T cell subsets and tissue-derived samples, repeated ex vivo quantitative and in vivo outgrowth assays in humanized mice did not reveal replication-competent virus...
March 2023: Nature Medicine
#39
JOURNAL ARTICLE
Melanie Borrmann, Florian Brandes, Benedikt Kirchner, Matthias Klein, Jean-Noël Billaud, Marlene Reithmair, Markus Rehm, Gustav Schelling, Michael W Pfaffl, Agnes S Meidert
BACKGROUND: Degradation of the endothelial protective glycocalyx layer during COVID-19 infection leads to shedding of major glycocalyx components. These circulating proteins and their degradation products may feedback on immune and endothelial cells and activate molecular signaling cascades in COVID-19 associated microvascular injury. To test this hypothesis, we measured plasma glycocalyx components in patients with SARS-CoV-2 infection of variable disease severity and identified molecular signaling networks activated by glycocalyx components in immune and endothelial cells...
2023: Frontiers in Immunology
#40
JOURNAL ARTICLE
Joy Edwards-Hicks, Petya Apostolova, Joerg M Buescher, Hannes Maib, Michal A Stanczak, Mauro Corrado, Ramon I Klein Geltink, Maria Elena Maccari, Matteo Villa, Gustavo E Carrizo, David E Sanin, Francesc Baixauli, Beth Kelly, Jonathan D Curtis, Fabian Haessler, Annette Patterson, Cameron S Field, George Caputa, Ryan L Kyle, Melanie Soballa, Minsun Cha, Harry Paul, Jacob Martin, Katarzyna M Grzes, Lea Flachsmann, Michael Mitterer, Liang Zhao, Frances Winkler, David Ali Rafei-Shamsabadi, Frank Meiss, Bertram Bengsch, Robert Zeiser, Daniel J Puleston, David O'Sullivan, Edward J Pearce, Erika L Pearce
How lipidome changes support CD8+ effector T (Teff ) cell differentiation is not well understood. Here we show that, although naive T cells are rich in polyunsaturated phosphoinositides (PIPn with 3-4 double bonds), Teff cells have unique PIPn marked by saturated fatty acyl chains (0-2 double bonds). PIPn are precursors for second messengers. Polyunsaturated phosphatidylinositol bisphosphate (PIP2 ) exclusively supported signaling immediately upon T cell antigen receptor activation. In late Teff cells, activity of phospholipase C-γ1, the enzyme that cleaves PIP2 into downstream mediators, waned, and saturated PIPn became essential for sustained signaling...
March 2023: Nature Immunology
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