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Melanie klein

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https://www.readbyqxmd.com/read/28262554/target-expression-generation-preclinical-activity-and-pharmacokinetics-of-the-bcma-t-cell-bispecific-antibody-em801-for-multiple-myeloma-treatment
#1
Anja Seckinger, Jose Antonio Delgado, Samuel Moser, Laura Moreno, Brigitte Neuber, Anna Grab, Susanne Lipp, Juana Merino, Felipe Prosper, Martina Emde, Camille Delon, Melanie Latzko, Reto Gianotti, Remo Lüoend, Ramona Murr, Ralf J Hosse, Lydia Jasmin Harnisch, Marina Bacac, Tanja Fauti, Christian Klein, Aintzane Zabaleta, Jens Hillengass, Elisabetta Ada Cavalcanti-Adam, Anthony D Ho, Michael Hundemer, Jesus F San Miguel, Klaus Strein, Pablo Umaña, Dirk Hose, Bruno Paiva, Minh Diem Vu
We identified B cell maturation antigen (BCMA) as a potential therapeutic target in 778 newly diagnosed and relapsed myeloma patients. We constructed an IgG-based BCMA-T cell bispecific antibody (EM801) and showed that it increased CD3(+) T cell/myeloma cell crosslinking, followed by CD4(+)/CD8(+) T cell activation, and secretion of interferon-γ, granzyme B, and perforin. This effect is CD4 and CD8 T cell mediated. EM801 induced, at nanomolar concentrations, myeloma cell death by autologous T cells in 34 of 43 bone marrow aspirates, including those from high-risk patients and patients after multiple lines of treatment, tumor regression in six of nine mice in a myeloma xenograft model, and depletion of BCMA(+) cells in cynomolgus monkeys...
February 27, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28211036/unconscious-phantasy-as-a-structural-principle-and-organizer-of-mental-life-the-evolution-of-a-concept-from-freud-to-klein-and-some-of-her-successors
#2
Heinz Weiss
Starting with Freud's discovery of unconscious phantasy as a means of accessing his patients' internal world, the author discusses the evolution of the concept in the work of Melanie Klein and some of her successors. Whereas Freud sees phantasy as a wish fulfilling imagination, dominated by primary process functioning and kept apart from reality testing, Klein understands phantasies as a structural function and organizer of mental life. From their very beginnings they involve object relations and gradually evolve from primitive body-near experiences to images and symbolic representations...
February 17, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28185996/rationale-design-and-baseline-data-of-a-cross-national-randomized-trial-on-the-effect-of-built-shade-in-public-parks-for-sun-protection
#3
David B Buller, Suzanne Dobbinson, Dallas R English, Melanie Wakefield, Mary Klein Buller
Environments can be structured to reduce solar ultraviolet radiation (UV) exposure to prevent skin cancer. A prospective randomized trial is being conducted to test whether introducing shade sails in passive recreation areas (PRAs) in public parks will increase use and decrease UV exposure in the shaded compared to unshaded PRAs. Shade effects will be compared between Melbourne, Australia and Denver, USA. The trial enrolled 145 public parks with PRAs suitable for shade construction and randomized parks to intervention or control in a 1:3 ratio...
April 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28145883/therapy-induced-developmental-reprogramming-of-prostate-cancer-cells-and-acquired-therapy-resistance
#4
Mannan Nouri, Josselin Caradec, Amy Anne Lubik, Na Li, Brett G Hollier, Mandeep Takhar, Manuel Altimirano-Dimas, Mengqian Chen, Mani Roshan-Moniri, Miriam Butler, Melanie Lehman, Jennifer Bishop, Sarah Truong, Shih-Chieh Huang, Dawn Cochrane, Michael Cox, Colin Collins, Martin Gleave, Nicholas Erho, Mohamed Alshalafa, Elai Davicioni, Colleen Nelson, Sheryl Gregory-Evans, R Jeffrey Karnes, Robert B Jenkins, Eric A Klein, Ralph Buttyan
Treatment-induced neuroendocrine transdifferentiation (NEtD) complicates therapies for metastatic prostate cancer (PCa). Based on evidence that PCa cells can transdifferentiate to other neuroectodermally-derived cell lineages in vitro, we proposed that NEtD requires first an intermediary reprogramming to metastable cancer stem-like cells (CSCs) of a neural class and we demonstrate that several different AR+/PSA+ PCa cell lines were efficiently reprogrammed to, maintained and propagated as CSCs by growth in androgen-free neural/neural crest (N/NC) stem medium...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28074416/proceedings-of-r%C3%A3-animation-2017-the-french-intensive-care-society-international-congress
#5
Chtara Kamilia, Kais Regaieg, Najeh Baccouch, Hedi Chelly, Mabrouk Bahloul, Mounir Bouaziz, Ali Jendoubi, Ahmed Abbes, Houda Belhaouane, Oussama Nasri, Layla Jenzri, Salma Ghedira, Mohamed Houissa, Kamal Belkadi, Youness Harti, Afak Nsiri, Khalid Khaleq, Driss Hamoudi, Rachid Harrar, Camille Thieffry, Frédéric Wallet, Erika Parmentier-Decrucq, Raphaël Favory, Daniel Mathieu, Julien Poissy, Thomas Lafon, Philippe Vignon, Emmanuelle Begot, Alexandra Appert, Mathilde Hadj, Paul Claverie, Morgan Matt, Olivier Barraud, Bruno François, Amira Jamoussi, Amira Ben Jazia, Takoua Marhbène, Dhouha Lakhdhar, Jalila Ben Khelil, Mohamed Besbes, Julien Goutay, Caroline Blazejewski, Isabelle Joly-Durand, Isabelle Pirlet, Marie Pierre Weillaert, Sebastien Beague, Soufi Aziz, Reda Hafiane, Khalid Hattabi, Mohamed Aziz Bouhouri, Driss Hammoudi, Abdelaziz Fadil, Rachid Al Harrar, Khalid Zerouali, Fatma Kaaniche Medhioub, Rania Allela, Najla Ben Algia, Samar Cherif, Mohamed Taoufik Slaoui, Souhail Boubia, Y Hafiani, A Khaoudi, R Cherkab, W Elallam, C Elkettani, L Barrou, M Ridaii, Rihi El Mehdi, Caroline Schimpf, Assaf Mizrahi, Benoît Pilmis, Alban Le Monnier, Kelly Tiercelet, Mélanie Cherin, Cédric Bruel, Francois Philippart, Sébastien Bailly, Jc Lucet, Alain Lepape, François L'hériteau, Martine Aupée, Caroline Bervas, Sandrine Boussat, Anne Berger-Carbonne, Anaïs Machut, Anne Savey, Jean-François Timsit, Keyvan Razazi, Jérémy Rosman, Nicolas de Prost, Guillaume Carteaux, Chloe Jansen, Jean Winoc Decousser, Christian Brun-Buisson, Armand Mekontso Dessap, Aymen M'rad, Zouhour Ouali, Manel Barghouth, Achille Kouatchet, Rafael Mahieu, Emmanuel Weiss, David Schnell, Jean-Ralph Zahar, Margaux Artiguenave, Paktoris-Papine Sophie, Florence Espinasse, Faten El Sayed, Aurélien Dinh, Cyril Charron, Guillaume Geri, Antoine Vieillard-Baron, Xavier Repessé, Hatem Kallel, Claire Mayence, Stéphanie Houcke, Pascal Guegueniat, Didier Hommel, Kaouther Dhifaoui, Zied Hajjej, Amira Fatnassi, Walid Sellami, Iheb Labbene, Mustapha Ferjani, Fahmi Dachraoui, Sabrine Nakkaa, Abdelwaheb M'ghirbi, Ali Adhieb, Dhouha Ben Braiek, Kmar Hraiech, Ali Ousji, Islem Ouanes, Hammouda Zaineb, Saousen Ben Abdallah, Lamia Ouanes-Besbes, Fekri Abroug, Simon Klein, Mattéo Miquet, Jean-Marc Thouret, Vincent Peigne, Jean-Louis Daban, Mathieu Boutonnet, Bernard Lenoir, Takoua Merhbene, Celine Derreumaux, Thierry Seguin, Jean-Marie Conil, Charlotte Kelway, Valery Blasco, Cyril Nafati, Karim Harti, Laurent Reydellet, Jacques Albanese, Narjess Ben Aicha, Khaoula Meddeb, Ahmed Khedher, Jihene Ayachi, Nesrine Fraj, Nesrine Sma, Imed Chouchene, Mohamed Boussarsar, Soumaya Ben Yedder, Walid Samoud, Bousselmi Radhouene, Bousselmi Mariem, Asma Ammar, Asma Ben Cheikh, Hend Ben Lakhal, Messaouda Khelfa, Yamina Hamdaoui, Nabiha Bouafia, Timothée Trampont, Thomas Daix, Vincent Legarçon, Henri Hani Karam, Nicolas Pichon, Fatma Essafi, Nasreddine Foudhaili, Hafedh Thabet, Youssef Blel, Nozha Brahmi, Hanane Ezzouine, Mahmoud Kerrous, Saad El Haoui, Soufiane Ahdil, Abdellatif Benslama, Khalid Abidi, Tarek Dendane, Ssouni Oussama, Jihane Belayachi, Naoufal Madani, Redouane Abouqal, Amine Ali Zeggwagh, Hatem Ghadhoune, Anis Chaari, Guissouma Jihene, Hend Allouche, Insaf Trabelsi, Habib Brahmi, Mohamed Samet, Hatem El Ghord, Ben Sik Ali Habiba, Nouira Hajer, Najla Tilouch, Sondes Yaakoubi, Oussama Jaoued, Rim Gharbi, Mohamed Fekih Hassen, Souheil Elatrous, Julien Arcizet, Bertrand Leroy, Caroline Abdulmalack, Catherine Renzullo, Maël Hamet, Jean-Marc Doise, Jérôme Coutet, Chaigar Mohammed Cheikh, Zakaria Quechar, Magalie Joris, Dimitri Titeca Beauport, Loay Kontar, Delphine Lebon, Bérengère Gruson, Michel Slama, Jean-Pierre Marolleau, Julien Maizel, Julie Gorham, Lieveke Ameye, Thierry Berghmans, Marianne Paesmans, Jean-Paul Sculier, Anne-Pascale Meert, Max Guillot, Marie-Pierre Ledoux, Thierry Braun, Quentin Maestraggi, Baptiste Michard, Vincent Castelain, Raoul Herbrecht, Francis Schneider, Severine Couffin, David Lobo, Nicolas Mongardon, Gilles Dhonneur, Roman Mounier, Pierrick Le Borgne, Sophie Couraud, Jean-Etienne Herbrecht, Alexandra Boivin, François Lefebvre, Pascal Bilbault, Setti-Aouicha Zelmat, Djamila-Djahida Batouche, Fatima Mazour, Belkacem Chaffi, Nadia Benatta, Ali Habiba Sik, I Talik, Maxime Perrier, Eliane Gouteix, Claude Koubi, Annabelle Escavy, Victoria Guilbaut, Jean-Philippe Fosse, Rahma Ben Jazia, Ahmed Abdelghani, Pierre-Julien Cungi, Julien Bordes, Cédric Nguyen, Candice Pierrou, Maximilien Cruc, Alain Benois, Frédéric Duprez, Thierry Bonus, Grégory Cuvelier, Sandra Ollieuz, Sharam Machayekhi, Frédéric Paciorkowski, Gregory Reychler, Remi Coudroy, Arnaud W Thille, Xavier Drouot, Véronique Diaz, Jean-Claude Meurice, René Robert, Olfa Turki, Hmida Chokri Ben, Mona Assefi, Romain Deransy, Hélène Brisson, Antoine Monsel, Filomena Conti, Olivier Scatton, Olivier Langeron, Hassen Ben Ghezala, Salah Snouda, Chiekh Imen Ben, Moez Kaddour, Anwar Armel, Lafrikh Youness, Bensaid Abdelhak, Miloudi Youssef, Al Harrar Najib, Amouzoun Mustapha, Mtioui Noufel, Zamd Mohamed, El Khayat Salma, Medkouri Ghizlane, Benghanam Mohamed, Ramdani Benyounes, Florent Montini, Sébastien Moschietto, Emilien Gregoire, Guillaume Claisse, Julien Guiot, Philippe Morimont, Jean-Marie Krzesinski, Christophe Mariat, Bernard Lambermont, Etienne Cavalier, Pierre Delanaye, Soumia Benbernou, Sofiane Ilies, Abdelkader Azza, Khalida Bouyacoub, Meriem Louail, Houria Mokhtari-Djebli, Romain Arrestier, Fabrice Daviaud, Xavier Laborne Francois, Elsa Brocas, Gérald Choukroun, Oscar Peñuelas, José-Angel Lorente, Pablo Cardinal-Fernandez, José-Maria Rodriguez, José-Antonio Aramburu, Andres Esteban, Fernando Frutos-Vivar, Laurent Bitker, Nicolas Costes, Didier Le Bars, Franck Lavenne, Mojgan Devouassoux, Jean-Christophe Richard, Malika Mechati, Marc Gainnier, Laurent Papazian, Christophe Guervilly, Aude Garnero, Jean Michel Arnal, Hadrien Roze, Jean Christophe Richard, Benjamin Repusseau, Antoine Dewitte, Olivier Joannes-Boyau, Alexandre Ouattara, Nadia Harbouze, A M Amine, A G Olandzobo, Alexandre Herbland, Marie Richard, Nicolas Girard, Lucile Lambron, Olivier Lesieur, Sarah Wainschtein, Sidonie Hubert, Albane Hugues, Marc Tran, Philippe Bouillard, Vlad Loteanu, Maxime Leloup, Alexandra Laurent, Florent Lheureux, Alessia Prestifilippo, Martin Delgado Maria Cruz, Rigal Romain, Massimo Antonelli, Torra Lluis Blanch, Franck Bonnetain, Maria Grazzia-Bocci, Jordi Mancebo, Emmanuel Samain, Hebert Paul, Gilles Capellier, Taissa Zavgorodniaia, Marion Soichot, Isabelle Malissin, Sebastian Voicu, Pierre Garçon, Antoine Goury, Lamia Kerdjana, Nicolas Deye, Emmanuel Bourgogne, Bruno Megarbane, Olfa Mejri, Marwa Ben Hmida, Salma Tannous, Lucie Chevillard, Laurence Labat, Patricia Risede, Hana Fredj, Maxime Léger, Marion Brunet, Gaël Le Roux, David Boels, Nicolas Lerolle, Souaad Farah, Hélène Amiel-Niemann, Nathalie Kubis, Xavier Declèves, Nicoals Peyraux, Frederic Baud, Micaela Serafini, Jean-Claude Alvarez, Annette Heinzelman, Mathieu Jozwiak, Sandrine Millasseau, Jean-Louis Teboul, Jean-Emmanuel Alphonsine, François Depret, Nathalie Richard, Pierre Attal, Christian Richard, Xavier Monnet, Denis Chemla, Salma Jerbi, Wafa Khedhiri, Hatem Necib, Paolo Scarfo, Charles Chevalier, Michael Piagnerelli, Alexandre Lafont, Antoine Galy, Claire Mancia, Amel Zerhouni, Kheira Tabeliouna, Ali Gaja, Bassem Hamrouni, Abir Malouch, Sami Fourati, Rihab Messaoud, Youssef Zarrouki, Amra Ziadi, Manal Rhezali, Zahira Zouizra, Drissi Boumzebra, Mohamed Abdennasser Samkaoui, Jennifer Brunet, Bertrand Canoville, Pierre Verrier, Calin Ivascau, Amélie Seguin, Xavier Valette, Damien Du Cheyron, Cedric Daubin, Wulfran Bougouin, Nadia Aissaoui, Lionel Lamhaut, Daniel Jost, Carole Maupain, Frankie Beganton, Adrien Bouglé, Florence Dumas, Eloi Marijon, Xavier Jouven, Alain Cariou, Florent Poirson, Ulriikka Chaput, Thomas Beeken, Leclerc Maxime, Oueslati Haikel, Dominique Vodovar, Jonathan Chelly, Philippe Marteau, Richard Chocron, Philippe Juvin, Thomas Loeb, Frederic Adnet, Eric Lecarpentier, Antoine Riviere, Bertand De Cagny, Thierry Soupison, Elodie Privat, Joséphine Escutnaire, Cyrielle Dumont, Valentine Baert, Christian Vilhelm, Hervé Hubert, Stéphane Leteurtre, Marion Fresco, Michael Bubenheim, Gaetan Beduneau, Dorothée Carpentier, Steven Grange, Elise Artaud-Macari, Benoit Misset, Fabienne Tamion, Christophe Girault, Guillaume Dumas, Sylvie Chevret, Virginie Lemiale, Djamel Mokart, Julien Mayaux, Frédéric Pène, Martine Nyunga, Pierre Perez, Anne-Sophie Moreau, Fabrice Bruneel, François Vincent, Kada Klouche, Jean Reignier, Antoine Rabbat, Elie Azoulay, Jean-Pierre Frat, Stéphanie Ragot, Jean-Michel Constantin, Gwenael Prat, Alain Mercat, Thierry Boulain, Alexandre Demoule, Jérôme Devaquet, Saad Nseir, Julien Charpentier, Laurent Argaud, Pascal Beuret, Jean-Damien Ricard, Christelle Teiten, Nicolas Marjanovic, Nicola Palamin, Erwan L'Her, Arthur Bailly, Julie Boisramé-Helms, Benoit Champigneulle, Toufik Kamel, Emmanuelle Mercier, Aurélie Le Thuaut, Jean-Baptiste Lascarrou, Amélie Rolle, Audrey De Jong, Gérald Chanques, Samir Jaber, Geoffroy Hariri, Jean-Luc Baudel, Vincent Dubée, Gabriel Preda, Simon Bourcier, Jeremie Joffre, Naïke Bigé, Hafid Ait-Oufella, Eric Maury, Houda Mater, Hamid Merdji, David Grimaldi, Christophe Rousseau, Jean-Paul Mira, Jean-Daniel Chiche, Ines Sedghiani, A Benabderrahim, Dhekra Hamdi, Asma Jendoubi, Mohamed Ali Cherif, Youssef Zied El Hechmi, Jerbi Zouheir, François Bagate, Radhwen Bousselmi, Frédérique Schortgen, Pierre Asfar, Emmanuel Guérot, Grelon Fabien, Nadia Anguel, Lasocki Sigismond, Henry-Lagarrigue Matthieu, Frédéric Gonzalez, Legay François, Christophe Guitton, Maleka Schenck, Doise Jean-Marc, Didier Dreyfuss, Peter Radermacher, Antoine Frère, Laurent Martin-Lefèvre, Gwenhaël Colin, Maud Fiancette, Matthieu Henry-Laguarrigue, Jean-Claude Lacherade, Christine Lebert, Isabelle Vinatier, Aihem Yehia, Aurélie Joret, Nicolas Menunier-Beillard, Dalila Benzekri-Lefevre, Arnaud Desachy, Fréderic Bellec, Gaëtan Plantefève, Jean-Pierre Quenot, Ferhat Meziani, Elsa Tavernier, Stephan Ehrmann, Nicolas Chudeau, Tommy Raveau, Valérie Moal, Pascal Houillier, Emmanuelle Rouve, Karim Lakhal, Charlotte Salmon Gandonnière, Youenn Jouan, Laetitia Bodet-Contentin, Adrien Balmier, Jonathan Messika, Etienne De Montmollin, Victorine Pouyet, Benjamin Sztrymf, Abirami Thiagarajah, Damien Roux, Marc Pineton De Chambrun, Charles-Edouard Luyt, François Beloncle, Nathalie Zapella, Stanislas Ledochowsky, Nicolas Terzi, Jean-Marc Mazou, Romain Sonneville, Sylvie Paulus, Yannick Fedun, Mickael Landais, Jean-Herlé Raphalen, Alain Combes, Zahir Amoura, Aemilia Jacquemin, Felipe Guerrero, Bertrand Marcheix, Nicolas Hernandez, Olivier Fourcade, Bernard Georges, Clément Delmas, Sarah Makoudi, Audrey Genton, Rémy Bernard, Guillaume Lebreton, Julien Amour, Charlotte Mazet, Fanny Bounes, Gurbuz Murat, Laure Cronier, Guillaume Robin, Caroline Biendel, Stein Silva, Samia Boubeche, Caroline Abriou, Véronique Wurtz, Vincent Scherrer, Nathalie Rey, Gioia Gastaldi, Benoit Veber, Fabien Doguet, Arnaud Gay, Bertrand Dureuil, Emmanuel Besnier, Antoine Rouget, Guillaume Gantois, Eric Magalhaes, Ruben Wanono, Roland Smonig, Mathilde Lermuzeaux, Jordane Lebut, Andremont Olivier, Claire Dupuis, Aguila Radjou, Bruno Mourvillier, Mathilde Neuville, Marie Pia D'ortho, Lila Bouadma, Anny Rouvel-Tallec, Marika Rudler, Nicolas Weiss, Vincent Perlbarg, Damien Galanaud, Dominique Thabut, Emna Rachdi, Ghada Mhamdi, Ahlem Trifi, Rim Abdelmalek, Sami Abdellatif, Foued Daly, Rochdi Nasri, Hanene Tiouiri, Salah Ben Lakhal, Geoffroy Rousseau, Romain Asmolov, Leslie Grammatico-Guillon, Adrien Auvet, Said Laribi, Denis Garot, Pierre François Dequin, Antoine Guillon, Jean-Louis Fergé, Gwénolé Abgrall, Ronan Hinault, Shazima Vally, Benoit Roze, Agathe Chaplain, Cyrille Chabartier, Anne-Charlotte Savidan, Sabia Marie, Andre Cabie, Dabor Resiere, Ruddy Valentino, Hossein Mehdaoui, Lucas Benarous, Marième Soda-Diop, Fouad Bouzana, Gilles Perrin, Jeremy Bourenne, Béatrice Eon, Dominique Lambert, Agnes Trebuchon, Géraldine Poncelet, Fleur Le Bourgeois, Levy Michael, Guillot Camille, Jérôme Naudin, Anna Deho, Stéphane Dauger, Michaël Sauthier, Krystale Bergeron-Gallant, Guillaume Emeriaud, Philippe Jouvet, Nicolas Tiebergien, Matthias Jacquet-Lagrèze, Jean-Luc Fellahi, Florent Baudin, Sandrine Essouri, Etienne Javouhey, Claude Guérin, Marie Lampin, Ouardia Mamouri, Patrick Devos, Yasemin Karaca-Altintas, Matthieu Vinchon, David Brossier, Redha Eltaani, Sonia Teyssedre, Meyet Sabine, Jean-Christophe Bouchut, Olivier Peguet, Lucie Petitdemange, Anne Sophie Guilbert, Nabil Tabet Aoul, Zakaria Addou, Nabil Aouffen, Benqqa Anas, Samira Kalouch, Khalid Yaqini, Aziz Chlilek, Rchi Abdou, Perrine Gravellier, Julie Chantreuil, Nadine Travers, Antoine Listrat, Claire Le Reun, Geraldine Favrais, Zoe Coppere, Stéphane Blanot, Juliette Montmayeur, Régis Bronchard, Stephane Rolando, Gilles Orliaguet, Pierre-Louis Leger, Jérôme Rambaud, Emilie Thueux, Alexandra De Larrard, Véronique Berthelot, Julien Denot, Marie Reymond, Alain Amblard, Sarah Morin-Zorman, Etienne Lengliné, Claire Pichereau, Eric Mariotte, Canet Emmanuel, Julien Poujade, Guillaume Trumpff, Ralf Janssen-Langenstein, Marie-Line Harlay, Noorah Zaid, Nawel Ait-Ammar, Christine Bonnal, Jean-Claude Merle, Francoise Botterel, Eric Levesque, Zakaria Riad, Mehdi Mezidi, Hodane Yonis, Mylène Aublanc, Sophie Perinel-Ragey, Floriane Lissonde, Aurore Louf-Durier, Romain Tapponnier, Bruno Louis, Jean-Marie Forel, Magali Bisbal, Samuel Lehingue, Romain Rambaud, Mélanie Adda, Sami Hraiech, Elisa Marchi, Antoine Roch, Vincent Guerin, Sacha Rozencwajg, Matthieu Schmidt, Guillaume Hekimian, Nicolas Bréchot, Jean Louis Trouillet, Sébastien Besset, Guillaume Franchineau, Ania Nieszkowska, Leprince Pascal, Maud Loiselle, Chemam Sarah, Dangers Laurence, Thomas Guillemette, Alice Jacquens, Sebastien Kerever, Bertrand Guidet, Philippe Aegerter, Vincent Das, Muriel Fartoukh, Jan Hayon, Mathieu Desmard, Jean-Pierre Fulgencio, Benjamin Zuber, A Soufi, K Khaleq, D Hamoudi, Charlotte Garret, Matthieu Peron, Emmanuel Coron, Cédric Bretonnière, Etienne Audureau, Winters Audrey, Duvoux Christophe, Jacquelinet Christian, Azoulay Daniel, Feray Cyrille, Wissal Aissaoui, Kawtar Rghioui, Wafae Haddad, Houcine Barrou, Anna Carteaux-Taeib, Renato Lupinacci, Gilles Manceau, Florence Jeune, Christophe Tresallet, Sahar Habacha, Ines Fathallah, Aymen Zoubli, Rafaa Aloui, Nadia Kouraichi, Emilie Jouet, Julie Badin, Brice Fermier, Marc Feller, Mathieu Serie, Jérôme Pillot, William Marie, Chloé Gisbert-Mora, Camille Vinclair, Pierre Lesbordes, Pascal Mathieu, Fabienne De Brabant, Emmanuel Muller, Marie-Aline Robaux, Mikhael Giabicani, Antoine Marchalot, Stéphanie Gelinotte, Pierre Louis Declercq, Jean-Pierre Eraldi, François Bougerol, Nicolas Meunier-Beillard, Hervé Devilliers, Jean-Philippe Rigaud, Camille Verrière, Fanny Ardisson, Nancy Kentish-Barnes, Gwenaëlle Jacq, Akli Chermak, Alexandre Lautrette, Matthieu Legrand, Alexis Soummer, Guillaume Thiery, Alice Cottereau, Emmanuel Canet, Marie Caujolle, Jérôme Allyn, Dorothée Valance, Caroline Brulliard, Olivier Martinet, Julien Jabot, Thomas Gallas, David Vandroux, Nicolas Allou, Arthur Durand, Rémi Nevière, Florian Delguste, Eric Boulanger, Sebastien Preau, Ruste Martin, Hélène Cochet, Jean Pierre Ponthus, Virginie Amilien, Martial Tchir, Elise Barsam, Mohsen Ayoub, Jean Francois Georger, Izaute Guillame, Julie Assaraf, Simona Tripon, Maxime Mallet, Guilaume Barbara, Guillaume Louis, Stéphane Gaudry, Nicolas Barbarot, Angéline Jamet, Hervé Outin, Sébastien Gibot, Pierre-Edouard Bollaert, Mathilde Holleville, Stéphane Legriel, Anne Laure Chateauneuf, Sébastien Cavelot, Jean-Denis Moyer, Jean Pierre Bedos, Philippe Merle, Aurelie Laine, De Sa Natalie, Mathieu Cornuault, Jérome Libot, Karim Asehnoune, Bertrand Rozec, Jacques Dantal, Michel Videcoq, Thècle Degroote, Emmanuelle Jaillette, Farid Zerimech, Balduyck Malika, Jean-François Llitjos, Marlène Amara, Guillaume Lacave, Béatrice Pangon, José Mavinga, Joseph Nsiala Makunza, M E Mafuta, Yves Yanga, Amisi Eric, Jp Ilunga, Ma Kilembe, Fanny Alby-Laurent, Julie Toubiana, Amel Mokline, Achraf Laajili, Helmi Amri, Imene Rahmani, Nidhal Mensi, Lazheri Gharsallah, Sofiene Tlaili, Bahija Gasri, Rym Hammouda, Amen Allah Messadi, Pierre-Antoine Allain, Nathallie Gault, Catherine Paugam-Burtz, Arnaud Foucrier, Bassem Chatbri, Yousra Bourbiaa, Lamia Thabet, Arthur Neuschwander, Looten Vincent, Jennifer Beck, Chhor Vibol, Yavchitz Amelie, Matthieu Resche-Rigon, Jean MantzRomain Pirracchio, Côme Bureau, Maxens Decavèle, Sébastien Campion, Roukia Ainsouya, Marie-Cécile Niérat, Hélène Prodanovic, Mathieu Raux, Thomas Similowski, Bruno-Pierre Dubé, Suela Demiri, Martin Dres, Faten May, Hervé Quintard, Ilias Kounis, Faouzi Saliba, Stephane André, Marc Boudon, Philippe Ichai, Aline Younes, Lionel Nakad, Audrey Coilly, Teresa Antonini, Rodolphe Sobesky, Eleonora De Martin, Didier Samuel, Noemie Hubert, Mai-Anh Nay, Johann Auchabie, Bruno Giraudeau, Reignier Jean, Michaël Darmon, Stephane Ruckly, Maïté Garrouste-Orgeas, Elisabeth Gratia, Dany Goldgran-Toledano, Samir Jamali, Anne Sylvie Dumenil, Carole Schwebel, Laurent Brisard, Philippe Bizouarn, Thierry Lepoivre, Johanna Nicolet, Jean Christophe Rigal, Jean Christian Roussel, Cherifa Cheurfa, Julien Abily, Thomas Lescot, Isaline Page, Stéphanie Warnier, Monique Nys, Anne-Françoise Rousseau, Pierre Damas, Fabrice Uhel, Mathieu Lesouhaitier, Murielle Grégoire, Baptiste Gaudriot, Arnaud Gacouin, Yves Le Tulzo, Erwan Flecher, Karin Tarte, Jean-Marc Tadié, Quentin Georges, M Soares, Kyeongman Jeon, Sandra Oeyen, Chin Kook Rhee, Pascale Gruber, Marlies Ostermann, Quentin Hill, Peter Depuydt, Christelle Ferra, Alice Muller, Bourmaud Aurelie, Christopher Niles, Fabien Herbert, Sylviane Pied, Séverine Loridant, Nadine François, Anne Bignon, Boualem Sendid, Caroline Lemaitre, Celine Dupre, Aymen Zayene, Lucie Portier, Nathalie De Freitas Caires, Philippe Lassalle, Aymeric Le Neindre, Pascal Selot, Daniel Ferreiro, Maria Bonarek, Stépahen Henriot, Julie Rodriguez, Mara Taddei, Mauro Di Bari, Cheryl Hickmann, Diego Castanares-Zapatero, Louise Deldicque, Peter Van Den Bergh, Gilles Caty, Jean Roeseler, Marc Francaux, Pierre-François Laterre, Bastien Dupuis, Sharam Machayeckhi, Celine Sarfati, Alex Moore, Paula Mendialdua, Emilie Rodet, Catherine Pilorge, Francois Stephan, Saida Rezaiguia-Delclaux, Jonathan Dugernier, Michel Hesse, Thibaud Jumetz, Emilie Bialais, Virginie Depoortere, Jean Bernard Michotte, Xavier Wittebole, François Jamar
No abstract text is available yet for this article.
January 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/27974799/early-dissemination-seeds-metastasis-in-breast-cancer
#6
Hedayatollah Hosseini, Milan M S Obradović, Martin Hoffmann, Kathryn L Harper, Maria Soledad Sosa, Melanie Werner-Klein, Lahiri Kanth Nanduri, Christian Werno, Carolin Ehrl, Matthias Maneck, Nina Patwary, Gundula Haunschild, Miodrag Gužvić, Christian Reimelt, Michael Grauvogl, Norbert Eichner, Florian Weber, Andreas D Hartkopf, Florin-Andrei Taran, Sara Y Brucker, Tanja Fehm, Brigitte Rack, Stefan Buchholz, Rainer Spang, Gunter Meister, Julio A Aguirre-Ghiso, Christoph A Klein
Accumulating data suggest that metastatic dissemination often occurs early during tumour formation, but the mechanisms of early metastatic spread have not yet been addressed. Here, by studying metastasis in a HER2-driven mouse breast cancer model, we show that progesterone-induced signalling triggers migration of cancer cells from early lesions shortly after HER2 activation, but promotes proliferation in advanced primary tumour cells. The switch from migration to proliferation was regulated by increased HER2 expression and tumour-cell density involving microRNA-mediated progesterone receptor downregulation, and was reversible...
December 14, 2016: Nature
https://www.readbyqxmd.com/read/27930337/genetic-immunological-and-clinical-features-of-patients-with-bacterial-and-fungal-infections-due-to-inherited-il-17ra-deficiency
#7
Romain Lévy, Satoshi Okada, Vivien Béziat, Kunihiko Moriya, Caini Liu, Louis Yi Ann Chai, Mélanie Migaud, Fabian Hauck, Amein Al Ali, Cyril Cyrus, Chittibabu Vatte, Turkan Patiroglu, Ekrem Unal, Marie Ferneiny, Nobuyuki Hyakuna, Serdar Nepesov, Matias Oleastro, Aydan Ikinciogullari, Figen Dogu, Takaki Asano, Osamu Ohara, Ling Yun, Erika Della Mina, Didier Bronnimann, Yuval Itan, Florian Gothe, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Natalia Tahuil, Caner Aytekin, Aicha Salhi, Saleh Al Muhsen, Masao Kobayashi, Julie Toubiana, Laurent Abel, Xiaoxia Li, Yildiz Camcioglu, Fatih Celmeli, Christoph Klein, Suzan A AlKhater, Jean-Laurent Casanova, Anne Puel
Chronic mucocutaneous candidiasis (CMC) is defined as recurrent or persistent infection of the skin, nails, and/or mucosae with commensal Candida species. The first genetic etiology of isolated CMC-autosomal recessive (AR) IL-17 receptor A (IL-17RA) deficiency-was reported in 2011, in a single patient. We report here 21 patients with complete AR IL-17RA deficiency, including this first patient. Each patient is homozygous for 1 of 12 different IL-17RA alleles, 8 of which create a premature stop codon upstream from the transmembrane domain and have been predicted and/or shown to prevent expression of the receptor on the surface of circulating leukocytes and dermal fibroblasts...
December 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27901350/blood-transfusion-requirement-and-not-preoperative-anemia-are-associated-with-perioperative-complications-following-intracorporeal-robot-assisted-radical-cystectomy
#8
Wei Shen Tan, Benjamin W Lamb, Pramit Khetrapal, Mae-Yen Tan, Melanie El Tan, Ashwin Sridhar, Elizabeth Cervi, Simon Rodney, Gerald Busuttil, Senthil Nathan, John Hines, Greg Shaw, Anna Mohammed, Hilary Baker, Timothy P Briggs, Andrew Klein, Toby Richards, John D Kelly
OBJECTIVES: To assess the prevalence of preoperative anemia and the impact of preoperative anemia and blood transfusion requirement on 30- and 90-day complications in a cohort of patients undergoing robot-assisted radical cystectomy with intracorporeal urinary diversion (iRARC). PATIENTS AND METHODS: IRARC was performed on 166 patients between June 2011 and March 2016. Prospective data were collected for patient demographics, clinical and pathologic characteristics, perioperative variables, transfusion requirements, and hospital length of stay...
February 2017: Journal of Endourology
https://www.readbyqxmd.com/read/27775041/stretching-human-mesenchymal-stromal-cells-on-stiffness-customized-collagen-type-i-generates-a-smooth-muscle-marker-profile-without-growth-factor-addition
#9
Miriam Rothdiener, Miriam Hegemann, Tatiana Uynuk-Ool, Brandan Walters, Piruntha Papugy, Phong Nguyen, Valentin Claus, Tanja Seeger, Ulrich Stoeckle, Karen A Boehme, Wilhelm K Aicher, Jan P Stegemann, Melanie L Hart, Bodo Kurz, Gerd Klein, Bernd Rolauffs
Using matrix elasticity and cyclic stretch have been investigated for inducing mesenchymal stromal cell (MSC) differentiation towards the smooth muscle cell (SMC) lineage but not in combination. We hypothesized that combining lineage-specific stiffness with cyclic stretch would result in a significantly increased expression of SMC markers, compared to non-stretched controls. First, we generated dense collagen type I sheets by mechanically compressing collagen hydrogels. Atomic force microscopy revealed a nanoscale stiffness range known to support myogenic differentiation...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27428585/rethinking-the-role-of-small-group-collaborators-and-adversaries-in-the-london-kleinian-development-1914-1968
#10
Joseph Aguayo, Agnes Regeczkey
The authors historically situate the London Kleinian development in terms of the small-group collaborations and adversaries that arose during the course of Melanie Klein's career. Some collaborations later became personally adversarial (e.g., those Klein had with Glover and Schmideberg); other adversarial relationships forever remained that way (with A. Freud); while still other long-term collaborations became theoretically contentious (such as with Winnicott and Heimann). After the Controversial Discussions in 1944, Klein marginalized one group of supporters (Heimann, Winnicott, and Riviere) in favor of another group (Rosenfeld, Segal, and Bion)...
July 2016: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/27399174/bidirectional-relations-between-temperament-and-parenting-predicting-preschool-age-children-s-adjustment
#11
Melanie R Klein, Liliana J Lengua, Stephanie F Thompson, Lyndsey Moran, Erika J Ruberry, Cara Kiff, Maureen Zalewski
Bidirectional associations between child temperament (fear, frustration, positive affect, effortful control) and parenting behaviors (warmth, negativity, limit setting, scaffolding, responsiveness) were examined as predictors of preschool-age children's adjustment problems and social competence. Participants were a community sample of children (N = 306; 50% female, 64% European American) and their mothers. Observational measures of child temperament and parenting were obtained using laboratory tasks at two time points (children's ages 36 and 54 months)...
July 11, 2016: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/27379816/pet-ct-identifies-reactivation-risk-in-cynomolgus-macaques-with-latent-m-tuberculosis
#12
Philana Ling Lin, Pauline Maiello, Hannah P Gideon, M Teresa Coleman, Anthony M Cadena, Mark A Rodgers, Robert Gregg, Melanie O'Malley, Jaime Tomko, Daniel Fillmore, L James Frye, Tara Rutledge, Robert M DiFazio, Christopher Janssen, Edwin Klein, Peter L Andersen, Sarah M Fortune, JoAnne L Flynn
Mycobacterium tuberculosis infection presents across a spectrum in humans, from latent infection to active tuberculosis. Among those with latent tuberculosis, it is now recognized that there is also a spectrum of infection and this likely contributes to the variable risk of reactivation tuberculosis. Here, functional imaging with 18F-fluorodeoxygluose positron emission tomography and computed tomography (PET CT) of cynomolgus macaques with latent M. tuberculosis infection was used to characterize the features of reactivation after tumor necrosis factor (TNF) neutralization and determine which imaging characteristics before TNF neutralization distinguish reactivation risk...
July 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27368338/identity-by-descent-fine-mapping-of-familial-adult-myoclonus-epilepsy-fame-to-2p11-2-2q11-2
#13
Lyndal Henden, Saskia Freytag, Zaid Afawi, Sara Baldassari, Samuel F Berkovic, Francesca Bisulli, Laura Canafoglia, Giorgio Casari, Douglas Ewan Crompton, Christel Depienne, Jozef Gecz, Renzo Guerrini, Ingo Helbig, Edouard Hirsch, Boris Keren, Karl Martin Klein, Pierre Labauge, Eric LeGuern, Laura Licchetta, Davide Mei, Caroline Nava, Tommaso Pippucci, Gabrielle Rudolf, Ingrid Eileen Scheffer, Pasquale Striano, Paolo Tinuper, Federico Zara, Mark Corbett, Melanie Bahlo
Familial adult myoclonus epilepsy (FAME) is a rare autosomal dominant disorder characterized by adult onset, involuntary muscle jerks, cortical myoclonus and occasional seizures. FAME is genetically heterogeneous with more than 70 families reported worldwide and five potential disease loci. The efforts to identify potential causal variants have been unsuccessful in all but three families. To date, linkage analysis has been the main approach to find and narrow FAME critical regions. We propose an alternative method, pedigree free identity-by-descent (IBD) mapping, that infers regions of the genome between individuals that have been inherited from a common ancestor...
October 2016: Human Genetics
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#14
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27240247/revisiting-the-crisis-in-freud-s-libido-theory-and-abraham-s-concept-of-the-oral-sadistic-phase-as-a-way-out-of-it
#15
Gerhard Dahl
The now available unabridged correspondence between Freud and Abraham leads to a re-evaluation of the significance of Abraham's work. The author proposes the thesis that clinical observations by Karl Abraham of the ambivalence of object relations and the destructive-sadistic aspects of orality have an important influence on the advancement of psychoanalytical theory. The phantasy problem of the Wolf Man and the question of the pathogenic relevance of early actual, or merely imagined traumata led Freud to doubt the validity of his theory...
October 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27207532/new-locus-for-skin-intrinsic-fluorescence-in-type-1-diabetes-also-associated-with-blood-and-skin-glycated-proteins
#16
Delnaz Roshandel, Ronald Klein, Barbara E K Klein, Bruce H R Wolffenbuttel, Melanie M van der Klauw, Jana V van Vliet-Ostaptchouk, Gil Atzmon, Danny Ben-Avraham, Jill P Crandall, Nir Barzilai, Shelley B Bull, Angelo J Canty, S Mohsen Hosseini, Linda T Hiraki, John Maynard, David R Sell, Vincent M Monnier, Patricia A Cleary, Barbara H Braffett, Andrew D Paterson
Skin fluorescence (SF) noninvasively measures advanced glycation end products (AGEs) in the skin and is a risk indicator for diabetes complications. N-acetyltransferase 2 (NAT2) is the only known locus influencing SF. We aimed to identify additional genetic loci influencing SF in type 1 diabetes (T1D) through a meta-analysis of genome-wide association studies (N = 1,359) including Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) and Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR)...
July 2016: Diabetes
https://www.readbyqxmd.com/read/26977147/long-term-quality-of-life-and-pregnancy-outcomes-of-differentiated-thyroid-cancer-survivors-treated-by-total-thyroidectomy-and-i-131-during-adolescence-and-young-adulthood
#17
Melanie Metallo, Lelia Groza, Laurent Brunaud, Marc Klein, Georges Weryha, Eva Feigerlova
Introduction. Differentiated thyroid cancer (DTC) is rare and confers good prognosis. Long-term health related quality of life (HRQoL) and pregnancy outcomes are not well known in subjects treated during adolescence and young adulthood. Methods. Cross-sectional analysis of HRQoL and global self-esteem, using SF-36 and ISP-25 surveys, and of pregnancy outcomes in female survivors of DTC treated by total thyroidectomy and I(131) before age of 25 years. Results. Forty-five of 61 patients (74%) responded to the survey...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/26912243/the-psychoanalytic-contributions-of-melitta-schmideberg-klein-more-than-melanie-klein-s-rebel-daughter
#18
Gabriele Cassullo
Compared to the impact of the work of Melanie Klein on the history of psychoanalysis, the contributions of her daughter, Melitta Schmideberg, passed almost unnoticed. At present, Schmideberg is solely remembered for having harshly attacked her mother at the start of the Controversial Discussions of the British Psycho-Analytical Society and for having coined the fitting expression "stable instability" in order to describe borderline and asocial personality disorders. However, the author discusses how the early groundbreaking discoveries of Klein with regards to primitive anxieties were the result of the joint work and thinking of Melanie and Melitta...
March 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/26869043/bone-marrow-derived-mesenchymal-stromal-cells-differ-in-their-attachment-to-fibronectin-derived-peptides-from-term-placenta-derived-mesenchymal-stromal-cells
#19
COMPARATIVE STUDY
Jan K Maerz, Lorenzo P Roncoroni, David Goldeck, Tanja Abruzzese, Hubert Kalbacher, Bernd Rolauffs, Peter DeZwart, Kay Nieselt, Melanie L Hart, Gerd Klein, Wilhelm K Aicher
INTRODUCTION: Human mesenchymal stromal cells (MSCs) can be isolated from different sources including bone marrow and term placenta. These two populations display distinct patterns of proliferation and differentiation in vitro. Since proliferation and differentiation of cells are modulated by cell-matrix interactions, we investigated the attachment of MSCs to a set of peptide-coated surfaces and explored their interactions with peptides in suspension. METHODS: Human MSCs were isolated from bone marrow and term placenta and expanded...
February 11, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/26836588/variants-in-trim22-that-affect-nod2-signaling-are-associated-with-very-early-onset-inflammatory-bowel-disease
#20
Qi Li, Cheng Hiang Lee, Lauren A Peters, Lucas A Mastropaolo, Cornelia Thoeni, Abdul Elkadri, Tobias Schwerd, Jun Zhu, Bin Zhang, Yongzhong Zhao, Ke Hao, Antonio Dinarzo, Gabriel Hoffman, Brian A Kidd, Ryan Murchie, Ziad Al Adham, Conghui Guo, Daniel Kotlarz, Ernest Cutz, Thomas D Walters, Dror S Shouval, Mark Curran, Radu Dobrin, Carrie Brodmerkel, Scott B Snapper, Christoph Klein, John H Brumell, Mingjing Hu, Ralph Nanan, Brigitte Snanter-Nanan, Melanie Wong, Francoise Le Deist, Elie Haddad, Chaim M Roifman, Colette Deslandres, Anne M Griffiths, Kevin J Gaskin, Holm H Uhlig, Eric E Schadt, Aleixo M Muise
BACKGROUND & AIMS: Severe forms of inflammatory bowel disease (IBD) that develop in very young children can be caused by variants in a single gene. We performed whole-exome sequence (WES) analysis to identify genetic factors that might cause granulomatous colitis and severe perianal disease, with recurrent bacterial and viral infections, in an infant of consanguineous parents. METHODS: We performed targeted WES analysis of DNA collected from the patient and her parents...
May 2016: Gastroenterology
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