keyword
https://read.qxmd.com/read/38504985/the-nf-%C3%AE%C2%BAb-rela-transcription-factor-is-not-required-for-cd8-t-cell-function-in-acute-viral-infection-and-cancer
#1
JOURNAL ARTICLE
Allison Voisin, Maud Plaschka, Marlène Perrin-Niquet, Julie Twardowski, Insaf Boutemine, Baptiste Eluard, Guilhem Lalle, Pierre Stéphan, Khaled Bouherrou, Laurie Tonon, Roxane Pommier, Anthony Ferrari, Ulf Klein, Mélanie Wencker, Véronique Baud, Philippe A Cassier, Yenkel Grinberg-Bleyer
CD8+ T cells are critical mediators of pathogen clearance and anti-tumor immunity. Although signaling pathways leading to the activation of NF-κB transcription factors have crucial functions in the regulation of immune responses, the CD8+ T cell-autonomous roles of the different NF-κB subunits, are still unresolved. Here, we investigated the function of the ubiquitously expressed transcription factor RelA in CD8+ T-cell biology using a novel mouse model and gene-edited human cells. We found that CD8+ T cell-specific ablation of RelA markedly altered the transcriptome of ex vivo stimulated cells, but maintained the proliferative capacity of both mouse and human cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38380940/regional-practice-variation-and-outcomes-in-the-standard-versus-accelerated-initiation-of-renal-replacement-therapy-in-acute-kidney-injury-starrt-aki-trial-a-post-hoc-secondary-analysis
#2
JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann, Sean M Bagshaw, Ron Wald, Neill K J Adhikari, Rinaldo Bellomo, Didier Dreyfuss, Bin Du, Martin P Gallagher, Stéphane Gaudry, Eric A Hoste, François Lamontagne, Michael Joannidis, Kathleen D Liu, Daniel F McAuley, Shay P McGuinness, Alistair D Nichol, Marlies Ostermann, Paul M Palevsky, Haibo Qiu, Ville Pettilä, Antoine G Schneider, Orla M Smith, Suvi T Vaara, Matthew Weir, Rinaldo Bellomo, Glenn M Eastwood, Leah Peck, Helen Young, Peter Kruger, Gordon Laurie, Emma Saylor, Jason Meyer, Ellen Venz, Krista Wetzig, Craig French, Forbes McGain, John Mulder, Gerard Fennessy, Sathyajith Koottayi, Samantha Bates, Miriam Towns, Rebecca Morgan, Anna Tippett, Andrew Udy, Chris Mason, Elisa Licari, Dashiell Gantner, Jason McClure, Alistair Nichol, Phoebe McCracken, Jasmin Board, Emma Martin, Shirley Vallance, Meredith Young, Chelsey Vladic, Steve McGloughlin, David Gattas, Heidi Buhr, Jennifer Coles, Debra Hutch, James Wun, Louise Cole, Christina Whitehead, Julie Lowrey, Kristy Masters, Rebecca Gresham, Victoria Campbell, David Gutierrez, Jane Brailsford, Loretta Forbes, Lauren Murray, Teena Maguire, Martina NiChonghaile, Neil Orford, Allison Bone, Tania Elderkin, Tania Salerno, Tim Chimunda, Jason Fletcher, Emma Broadfield, Sanjay Porwal, Cameron Knott, Catherine Boschert, Julie Smith, Angus Richardson, Dianne Hill, Graeme Duke, Peter Oziemski, Santiago Cegarra, Peter Chan, Deborah Welsh, Stephanie Hunter, Owen Roodenburg, John Dyett, Nicos Kokotsis, Max Moser, Yang Yang, Laven Padayachee, Joseph Vetro, Himangsu Gangopadhyay, Melissa Kaufman, Angaj Ghosh, Simone Said, Alpesh Patel, Shailesh Bihari, Elisha Matheson, Xia Jin, Tapaswi Shrestha, Kate Schwartz, Martin P Gallagher, Rosalba Cross, Winston Cheung, Helen Wong, Mark Kol, Asim Shah, Amanda Y Wang, Zoltan Endre, Celia Bradford, Pierre Janin, Simon Finfer, Naomi Diel, Jonathan Gatward, Naomi Hammond, Anthony Delaney, Frances Bass, Elizabeth Yarad, Hergen Buscher, Claire Reynolds, Nerilee Baker, Michael Joannidis, Romuald Bellmann, Andreas Peer, Julia Hasslacher, Paul Koglberger, Sebastian Klein, Klemens Zotter, Anna Brandtner, Armin Finkenstedt, Adelheid Ditlbacher, Frank Hartig, Dietmar Fries, Mirjam Bachler, Bettina Schenk, Martin Wagner, Thomas Staudinger, Esther Tiller, Peter Schellongowski, Andja Bojic, Eric A Hoste, Stephanie Bracke, Luc De Crop, Daisy Vermeiren, Fernando Thome, Bianca Chiella, Lucia Fendt, Veronica Antunes, Maisonneuve-Rosemont, Jean-Philippe Lafrance, François Lamontagne, Frédérick D'Aragon, Charles St-Arnaud, Michael Mayette, Élaine Carbonnaeu, Joannie Marchand, Marie-Hélène Masse, Marilène Ladouceur, Alexis F Turgeon, François Lauzier, David Bellemare, Charles Langis Francoeur, Guillaume LeBlanc, Gabrielle Guilbault, Stéphanie Grenier, Eve Cloutier, Annick Boivin, Charles Delisle-Thibault, Panagiota Giannakouros, Olivier Costerousse, Jean-François Cailhier, François-Martin Carrier, Ali Ghamraoui, Martine Lebrasseur, Fatna Benettaib, Maya Salamé, Dounia Boumahni, Ying Tung Sia, Jean-François Naud, Isabelle Roy, Henry T Stelfox, Stacey Ruddell, Braden J Manns, Shelley Duggan, Dominic Carney, Jennifer Barchard, Richard P Whitlock, Emilie Belley-Cote, Nevena Savija, Alexandra Sabev, Troy Campbell, Thais Creary, Kelson Devereaux, Shira Brodutch, Claudio Rigatto, Bojan Paunovic, Owen Mooney, Anna Glybina, Oksana Harasemiw, Michelle Di Nella, John Harmon, Navdeep Mehta, Louis Lakatos, Nicole Haslam, Francois Lellouche, Mathieu Simon, Ying Tung, Patricia Lizotte, Pierre-Alexandre Bourchard, Bram Rochwerg, Tim Karachi, Tina Millen, John Muscedere, David Maslove, J Gordon Boyd, Stephanie Sibley, John Drover, Miranda Hunt, Ilinca Georgescu, Randy Wax, Ilan Lenga, Kavita Sridhar, Andrew Steele, Kelly Fusco, Taneera Ghate, Michael Tolibas, Holly Robinson, Matthew A Weir, Ravi Taneja, Ian M Ball, Amit Garg, Eileen Campbell, Athena Ovsenek, Sean M Bagshaw, Sean van Diepen, Nadia Baig, Sheldon Magder, Han Yao, Ahsan Alam, Josie Campisi, Erika MacIntyre, Ella Rokosh, Kimberly Scherr, Stephen Lapinsky, Sangeeta Mehta, Sumesh Shah, Daniel J Niven, Henry T Stelfox, Stacey Ruddell, Michael Russell, Kym Jim, Gillian Brown, Kerry Oxtoby, Adam Hall, Luc Benoit, Colleen Sokolowski, Bhanu Prasad, Jag Rao, Shelley Giebel, Demetrios J Kutsogiannis, Patricia Thompson, Tayne Thompson, Robert Cirone, Kanthi Kavikondala, Mark Soth, France Clarke, Alyson Takaoka, Ron Wald, David Mazer, Karen Burns, Jan Friedrich, David Klein, Gyan Sandhu, Marlene Santos, Imrana Khalid, Jennifer Hodder, Peter Dodek, Najib Ayas, Victoria Alcuaz, Gabriel Suen, Oleksa Rewa, Gurmeet Singh, Sean Norris, Neil Gibson, Castro Arias, Aysha Shami, Celine Pelletier, Neill K J Adhikari, Alireza Zahirieh, Andre Amaral, Nicole Marinoff, Navjot Kaur, Adic Perez, Jane Wang, Gregory Haljan, Christopher Condin, Lauralyn McIntyre, Brigette Gomes, Rebecca Porteous, Irene Watpool, Swapnil Hiremath, Edward Clark, Margaret S Herridge, Felicity Backhouse, M Elizabeth Wilcox, Karolina Walczak, Vincent Ki, Asheer Sharman, Martin Romano, Sean M Bagshaw, R T Noel Gibney, Adam S Romanovsky, Oleksa Rewa, Lorena McCoshen, Nadia Baig, Gordon Wood, Daniel Ovakim, Fiona Auld, Gayle Carney, Meili Duan, Xiaojun Ji, Dongchen Guo, Zhili Qi, Jin Lin, Meng Zhang, Lei Dong, Jingfeng Liu, Pei Liu, Deyuan Zhi, Guoqiang Bai, Yu Qiu, Ziqi Yang, Jing Bai, Zhuang Liu, Haizhou Zhuang, Haiman Wang, Jian Li, Mengya Zhao, Xiao Zhou, Xianqing Shi, Baning Ye, Manli Liu, Jing Wu, Yongjian Fu, Dali Long, Yu Pan, Jinlong Wang, Huaxian Mei, Songsong Zhang, Mingxiang Wen, Enyu Yang, Sijie Mu, Jianquan Li, Tingting Hu, Bingyu Qin, Min Li, Cunzhen Wang, Xin Dong, Kaiwu Wang, Haibo Wang, Jianxu Yang, Bin Du, Chuanyao Wang, Dongxin Wang, Nan Li, Zhui Yu, Song Xu, Lan Yao, Guo Hou, Zhou Liu, Liping Lu, Yingtao Lian, Chunting Wang, Jichen Zhang, Ruiqi Ding, Guoqing Qi, Qizhi Wang, Peng Wang, Zhaoli Meng, Man Chen, Xiaobo Hu, Xiandi He, Shibing Zhao, Lele Hang, Rui Li, Suhui Qin, Kun Lu, Shijuan Dun, Cheng Liu, Qi Zhou, Zhenzhen Chen, Jing Mei, Minwei Zhang, Hao Xu, Jincan Lin, Qindong Shi, Lijuan Fu, Qinjing Zeng, Hongye Ma, Jinqi Yan, Lan Gao, Hongjuan Liu, Lei Zhang, Hao Li, Xiaona He, Jingqun Fan, Litao Guo, Yu Liu, Xue Wang, Jingjing Sun, Zhongmin Liu, Juan Yang, Lili Ding, Lulu Sheng, Xingang Liu, Jie Yan, Quihui Wang, Yifeng Wang, Dan Zhao, Shuangping Zhao, Chenghuan Hu, Jing Li, Fuxing Deng, Haibo Qiu, Yi Yang, Min Mo, Chun Pan, Changde Wu, Yingzi Huang, Lili Huang, Airan Liu, Ville Pettilä, Suvi T Vaara, Anna-Maija Korhonen, Sanna Törnblom, Sari Sutinen, Leena Pettilä, Jonna Heinonen, Eliria Lappi, Taria Suhonen, Sari Karlsson, Sanna Hoppu, Ville Jalkanen, Anne Kuitunen, Markus Levoranta, Jaakko Långsjö, Sanna Ristimäki, Kaisa Malila, Anna Wootten, Simo Varila, Mikko J Järvisalo, Outi Inkinen, Satu Kentala, Keijo Leivo, Paivi Haltia, Didier Dreyfuss, Jean-Damien Ricard, Jonathan Messika, Abirami Tiagarajah, Malo Emery, Aline Dechanet, Coralie Gernez, Damien Roux, Laurent Martin-Lefevre, Maud Fiancette, Isabelle Vinatier, Jean Claude Lacherade, Gwenhaël Colin, Christine Lebert, Marie-Ange Azais, Aihem Yehia, Caroline Pouplet, Matthieu Henry-Lagarrigue, Amélie Seguin, Laura Crosby, Julien Maizel, Dimitri Titeca-Beauport, Alain Combes, Ania Nieszkowska, Paul Masi, Alexandre Demoule, Julien Mayaux, Martin Dres, Elise Morawiec, Maxens Decalvele, Suela Demiri, Morgane Faure, Clémence Marios, Maxime Mallet, Marie Amélie Ordon, Laura Morizot, Marie Cantien, François Pousset, Stéphane Gaudry, Florent Poirson, Yves Cohen, Laurent Argaud, Martin Cour, Laurent Bitker, Marie Simon, Romain Hernu, Thomas Baudry, Sylvie De La Salle, Adrien Robine, Nicholas Sedillot, Xavier Tchenio, Camille Bouisse, Sylvie Roux, Davide Barbar, Rémi Trusson, Fabienne Tamion, Steven Grangé, Dorothée Carpentier, Guillaume Chevrel, Luis Ensenyat-Martin, Sophie Marque, Jean-Pierre Quenot, Pascal Andreu, Auguste Dargent, Audrey Large, Nicolas Chudeau, Mickael Landais, Benoit Derrien, Jean Christophe Callahan, Christophe Guitton, Charlène Le Moal, Alain Robert, Karim Asehnoune, Raphaël Cinotti, Nicolas Grillot, Dominique Demeure, Christophe Vinsonneau, Imen Rahmani, Mehdi Marzouk, Thibault Dekeyser, Caroline Sejourne, Mélanie Verlay, Fabienne Thevenin, Lucie Delecolle, Lens Didier Thevenin, Bertrand Souweine, Elisabeth Coupez, Mireille Adda, Jean-Pierre Eraldi, Antoine Marchalot, Nicolas De Prost, Armand Mekontso Dessap, Keyvan Razazi, Ferhat Meziani, Julie Boisrame-Helms, Raphael Clere-Jehl, Xavier Delabranche, Christine Kummerlen, Hamid Merdji, Alexandra Monnier, Yannick Rabouel, Hassene Rahmani, Hayat Allam, Samir Chenaf, Vincenta Franja, Bertrand Pons, Michel Carles, Frédéric Martino, Régine Richard, Benjamin Zuber, Guillaume Lacave, Karim Lakhal, Bertrand Rozec, Hoa Dang Van, Éric Boulet, René Dubos, Fouad Fadel, Cedric Cleophax, Nicolas Dufour, Caroline Grant, Marie Thuong, Jean Reignier, Emmanuel Canet, Laurent Nicolet, Thierry Boulain, Mai-Anh Nay, Dalila Benzekri, François Barbier, Anne Bretagnol, Toufik Kamel, Armelle Mathonnet, Grégoire Muller, Marie Skarzynski, Julie Rossi, Amandine Pradet, Sandra Dos Santos, Aurore Guery, Lucie Muller, Luis Felix, Julien Bohé, Guillaume Thiéry, Nadia Aissaoui, Damien Vimpere, Morgane Commeureuc, Jean-Luc Diehl, Emmanuel Guerot, Orfeas Liangos, Monika Wittig, Alexander Zarbock, Mira Küllmar, Thomas van Waegeningh, Nadine Rosenow, Alistair D Nichol, Kathy Brickell, Peter Doran, Patrick T Murray, Giovanni Landoni, Rosalba Lembo, Alberto Zangrillo, Giacomo Monti, Margherita Tozzi, Matteo Marzaroli, Gaetano Lombardi, Gianluca Paternoster, Michelangelo Vitiello, Shay McGuinness, Rachael Parke, Magdalena Butler, Eileen Gilder, Keri-Anne Cowdrey, Samantha Wallace, Jane Hallion, Melissa Woolett, Philippa Neal, Karina Duffy, Stephanie Long, Colin McArthur, Catherine Simmonds, Yan Chen, Rachael McConnochie, Lynette Newby, David Knight, Seton Henderson, Jan Mehrtens, Stacey Morgan, Anna Morris, Kymbalee Vander Hayden, Tara Burke, Matthew Bailey, Ross Freebairn, Lesley Chadwick, Penelope Park, Christine Rolls, Liz Thomas, Ulrike Buehner, Erin Williams, Jonathan Albrett, Simon Kirkham, Carolyn Jackson, Troy Browne, Jennifer Goodson, David Jackson, James Houghton, Owen Callender, Vicki Higson, Owen Keet, Clive Dominy, Paul Young, Anna Hunt, Harriet Judd, Cassie Lawrence, Shaanti Olatunji, Yvonne Robertson, Charlotte Latimer-Bell, Deborah Hendry, Agnes Mckay-Vucago, Nina Beehre, Eden Lesona, Leanlove Navarra, Chelsea Robinson, Ryan Jang, Andrea Junge, Bridget Lambert, Antoine G Schneider, Michel Thibault, Philippe Eckert, Sébastien Kissling, Erietta Polychronopoulos, Elettra Poli, Marco Altarelli, Madeleine Schnorf, Samia Abed Mallaird, Claudia Heidegger, Aurelie Perret, Philippe Montillier, Frederic Sangla, Seigenthaller Neils, Aude De Watteville, Mandeep-Kaur Phull, Aparna George, Nauman Hussain, Tatiana Pogreban, Steve Lobaz, Alison Daniels, Mishell Cunningham, Deborah Kerr, Alice Nicholson, Pradeep Shanmugasundaram, Judith Abrams, Katarina Manso, Geraldine Hambrook, Elizabeth McKerrow, Juvy Salva, Stephen Foulkes, Matthew Wise, Matt Morgan, Jenny Brooks, Jade Cole, Tracy Michelle Davies, Helen Hill, Emma Thomas, Marcela Vizcaychipi, Behrad Baharlo, Jaime Carungcong, Patricia Costa, Laura Martins, Ritoo Kapoor, Tracy Hazelton, Angela Moon, Janine Musselwhite, Ben Shelley, Philip McCall, Marlies Ostermann, Gill Arbane, Aneta Bociek, Martina Marotti, Rosario Lim, Sara Campos, Neus Grau Novellas, Armando Cennamo, Andrew Slack, Duncan Wyncoll, Luigi Camporota, Simon Sparkes, Rosalinde Tilley, Austin Rattray, Gayle Moreland, Jane Duffy, Elizabeth McGonigal, Philip Hopkins, Clare Finney, John Smith, Harriet Noble, Hayley Watson, Claire-Louise Harris, Emma Clarey, Eleanor Corcoran, James Beck, Clare Howcroft, Nora Youngs, Elizabeth Wilby, Bethan Ogg, Adam Wolverson, Sandra Lee, Susie Butler, Maryanne Okubanjo, Julia Hindle, Ingeborg Welters, Karen Williams, Emily Johnson, Julie Patrick-Heselton, David Shaw, Victoria Waugh, Richard Stewart, Esther Mwaura, Lynn Wren, Louise Mew, Sara-Beth Sutherland, Jane Adderley, Jim Ruddy, Margaret Harkins, Callum Kaye, Teresa Scott, Wendy Mitchell, Felicity Anderson, Fiona Willox, Vijay Jagannathan, Michele Clark, Sarah Purv, Andrew Sharman, Megan Meredith, Lucy Ryan, Louise Conner, Cecilia Peters, Dan Harvey, Ashraf Roshdy, Amy Collins, Malcolm Sim, Steven Henderson, Nigel Chee, Sally Pitts, Katie Bowman, Maria Dilawershah, Luke Vamplew, Elizabeth Howe, Paula Rogers, Clara Hernandez, Clara Prendergast, Jane Benton, Alex Rosenberg, Lui G Forni, Alice Grant, Paula Carvelli, Ajay Raithatha, Sarah Bird, Max Richardson, Matthew Needham, Claire Hirst, Jonathan Ball, Susannah Leaver, Luisa Howlett, Carlos Castro Delgado, Sarah Farnell-Ward, Helen Farrah, Geraldine Gray, Gipsy Joseph, Francesca Robinson, Ascanio Tridente, Clare Harrop, Karen Shuker, Derek McLaughlan, Judith Ramsey, Sharon Meehan, Bernd Oliver Rose, Rosie Reece-Anthony, Babita Gurung, Tony Whitehouse, Catherine Snelson, Tonny Veenith, Andy Johnston, Lauren Cooper, Ron Carrera, Karen Ellis, Emma Fellows, Samanth Harkett, Colin Bergin, Elaine Spruce, Liesl Despy, Stephanie Goundry, Natalie Dooley, Tracy Mason, Amy Clark, Gemma Dignam, Geraldine Ward, Ben Attwood, Penny Parsons, Sophie Mason, Michael Margarson, Jenny Lord, Philip McGlone, Luke E Hodgson, Indra Chadbourn, Raquel Gomez, Jordi Margalef, Rinus Pretorius, Alexandra Hamshere, Joseph Carter, Hazel Cahill, Lia Grainger, Kate Howard, Greg Forshaw, Zoe Guy, Kianoush B Kashani, Robert C Albright, Amy Amsbaugh, Anita Stoltenberg, Alexander S Niven, Matthew Lynch, AnnMarie O'Mara, Syed Naeem, Sairah Sharif, Joyce McKenney Goulart, Matthew Lynch, AnnMarie O'Mara, Syed Naeem, Sairah Sharif, Joyce McKenney Goulart, Ashita Tolwani, Claretha Lyas, Laura Latta, Azra Bihorac, Haleh Hashemighouchani, Philip Efron, Matthew Ruppert, Julie Cupka, Sean Kiley, Joshua Carson, Peggy White, George Omalay, Sherry Brown, Laura Velez, Alina Marceron, Javier A Neyra, Juan Carlos Aycinena, Madona Elias, Victor M Ortiz-Soriano, Caroline Hauschild, Robert Dorfman
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
https://read.qxmd.com/read/38241788/examining-cefazolin-utilization-and-perioperative-anaphylaxis-in-patients-with-and-without-a-penicillin-allergy-label-a-cross-sectional-study
#3
JOURNAL ARTICLE
Zachary R Murphy, Anum F Muzaffar, Sandra A Massih, Eili Y Klein, Melanie C Dispenza, Valeria Fabre, Nadia B Hensley, Kimberly G Blumenthal, Santiago Alvarez-Arango
STUDY OBJECTIVE: To compare the occurrence of cefazolin perioperative anaphylaxis (POA) in patients with and without a penicillin allergy label (PAL) to determine whether the prevalence of cefazolin POA differs based on the presence of a PAL. DESIGN: Cross-sectional study. SETTING: A large U.S. healthcare system in the Baltimore-D.C. region, July 2017 to July 2020. PATIENTS: 112,817 surgical encounters across inpatient and outpatient settings in various specialties, involving 90,089 patients...
January 18, 2024: Journal of Clinical Anesthesia
https://read.qxmd.com/read/38195117/cln3-deficiency-leads-to-neurological-and-metabolic-perturbations-during-early-development
#4
JOURNAL ARTICLE
Ursula Heins-Marroquin, Randolph R Singh, Simon Perathoner, Floriane Gavotto, Carla Merino Ruiz, Myrto Patraskaki, Gemma Gomez-Giro, Felix Kleine Borgmann, Melanie Meyer, Anaïs Carpentier, Marc O Warmoes, Christian Jäger, Michel Mittelbronn, Jens C Schwamborn, Maria Lorena Cordero-Maldonado, Alexander D Crawford, Emma L Schymanski, Carole L Linster
Juvenile neuronal ceroid lipofuscinosis (or Batten disease) is an autosomal recessive, rare neurodegenerative disorder that affects mainly children above the age of 5 yr and is most commonly caused by mutations in the highly conserved CLN3 gene. Here, we generated cln3 morphants and stable mutant lines in zebrafish. Although neither morphant nor mutant cln3 larvae showed any obvious developmental or morphological defects, behavioral phenotyping of the mutant larvae revealed hyposensitivity to abrupt light changes and hypersensitivity to pro-convulsive drugs...
March 2024: Life Science Alliance
https://read.qxmd.com/read/38176906/mild-deficits-in-fear-learning-evidence-from-humans-and-mice-with-cerebellar-cortical-degeneration
#5
JOURNAL ARTICLE
Giorgi Batsikadze, Johanna Pakusch, Michael Klein, Thomas Michael Ernst, Andreas Thieme, Seyed Ali Nicksirat, Katharina Marie Steiner, Enzo Nio, Erhan Genc, Stefan Maderwald, Cornelius Deuschl, Christian Josef Merz, Harald H Quick, Melanie D Mark, Dagmar Timmann
Functional brain imaging studies in humans suggest involvement of the cerebellum in fear conditioning but do not allow conclusions about the functional significance. The main aim of the present study was to examine whether patients with cerebellar degeneration show impaired fear conditioning and whether this is accompanied by alterations in cerebellar cortical activations. To this end, a 2 d differential fear conditioning study was conducted in 20 cerebellar patients and 21 control subjects using a 7 tesla (7 T) MRI system...
February 2024: ENeuro
https://read.qxmd.com/read/38127478/the-ego-and-the-id-concepts-and-developments
#6
JOURNAL ARTICLE
Franco De Masi
In this note I have limited myself to describing some convergent and divergent developments arising from the innovative concepts present in The Ego and the Id. It could be argued that a part of the psychoanalytic movement wished to emphasize the function of the Ego (Anna Freud, Hartmann, Rapaport), while another part (Melanie Klein and her followers) delved into the dynamics of the Superego and the Id in primitive and pathological states of mind. I will examine three themes presents in The Ego and the Id: the assertion that a part of the Ego is unconscious; the idea that the death drive becomes part of the dynamics of melancholia and its Superego; the concept of fusion and defusion of the life and death instinct...
December 2023: International Journal of Psycho-analysis
https://read.qxmd.com/read/38115715/cardio-renal-metabolic-disease-in-primary-care-setting
#7
REVIEW
Mahmoud Ibrahim, Ebtesam M Ba-Essa, Jason Baker, Avivit Cahn, Antonio Ceriello, Francesco Cosentino, Melanie J Davies, Robert H Eckel, Luc Van Gaal, Peter Gaede, Yehuda Handelsman, Samuel Klein, Richard David Leslie, Paolo Pozzilli, Stefano Del Prato, Francesco Prattichizzo, Oliver Schnell, Petar M Seferovic, Eberhard Standl, Abraham Thomas, Jaakko Tuomilehto, Paul Valensi, Guillermo E Umpierrez
In the primary care setting providers have more tools available than ever before to impact positively obesity, diabetes, and their complications, such as renal and cardiac diseases. It is important to recognise what is available for treatment taking into account diabetes heterogeneity. For those who develop type 2 diabetes (T2DM), effective treatments are available that for the first time have shown a benefit in reducing mortality and macrovascular complications, in addition to the well-established benefits of glucose control in reducing microvascular complications...
December 19, 2023: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38011761/cytogenetics-in-the-management-of-myeloproliferative-neoplasms-mastocytosis-and-myelodysplastic-myeloproliferative-neoplasms-guidelines-from-the-group-francophone-de-cytog%C3%A3-n%C3%A3-tique-h%C3%A3-matologique-gfch
#8
Matthieu Decamp, Emilie Klein, Catherine Godon, Valentin Lestringant, Pauline Roynard, Olivier Theisen, Mélanie Jimenez-Pocquet, Catherine Roche-Lestienne, Audrey Bidet, Lauren Veronese
Myeloproliferative neoplasms, mastocytosis, myeloid/lymphoid neoplasms with hypereosinophilia and tyrosine kinase gene fusions, and myelodysplastic/myeloproliferative neoplasms are clonal hematopoietic cancers that, with the exception of certain entities, have an indolent course. In addition to their increasingly important role in the diagnosis of these entities, as shown by the recent classification of hematolymphoid tumors in the 5th edition of the World Health Organization and the International Consensus Classification of myeloid neoplasms and acute leukemias, identification of the profile of acquired genetic abnormalities is essential for adapting patient management and early detection of patients at high risk of progression...
October 20, 2023: Current Research in Translational Medicine
https://read.qxmd.com/read/37988996/different-whole-brain-functional-connectivity-correlates-of-reactive-proactive-aggression-and-callous-unemotional-traits-in-children-and-adolescents-with-disruptive-behaviors
#9
JOURNAL ARTICLE
Julia E Werhahn, Lukasz Smigielski, Seda Sacu, Susanna Mohl, David Willinger, Jilly Naaijen, Leandra M Mulder, Jeffrey C Glennon, Pieter J Hoekstra, Andrea Dietrich, Renee Kleine Deters, Pascal M Aggensteiner, Nathalie E Holz, Sarah Baumeister, Tobias Banaschewski, Melanie C Saam, Ulrike M E Schulze, David J Lythgoe, Arjun Sethi, Michael Craig, Mathilde Mastroianni, Ilyas Sagar-Ouriaghli, Paramala J Santosh, Mireia Rosa, Nuria Bargallo, Josefina Castro-Fornieles, Celso Arango, Maria J Penzol, Marcel P Zwiers, Barbara Franke, Jan K Buitelaar, Susanne Walitza, Daniel Brandeis
BACKGROUND: Disruptive behavior in children and adolescents can manifest as reactive aggression and proactive aggression and is modulated by callous-unemotional traits and other comorbidities. Neural correlates of these aggression dimensions or subtypes and comorbid symptoms remain largely unknown. This multi-center study investigated the relationship between resting state functional connectivity (rsFC) and aggression subtypes considering comorbidities. METHODS: The large sample of children and adolescents aged 8-18 years (n = 207; mean age = 13...
November 13, 2023: NeuroImage: Clinical
https://read.qxmd.com/read/37972341/karl-abraham-the-origins-of-projective-identification-and-the-day-of-atonement
#10
JOURNAL ARTICLE
Seth Aronson
Karl Abraham, one of Melanie Klein's analysts, undoubtedly influenced Klein in her clinical and theoretical thinking. Abraham was arguably the first analyst to focus on character, as well as the relationship between bodily experience and object relationships-central to the concept of projective identification. His writing on mourning (like Klein's, intensely personal) described identificatory processes with the lost object. In a lesser known essay, Abraham applied some of these ideas to the Jewish Day of Atonement, Yom Kippur...
2023: Psychoanalytic Quarterly
https://read.qxmd.com/read/37957379/dynamics-and-durability-of-hiv-1-neutralization-are-determined-by-viral-replication
#11
JOURNAL ARTICLE
Philipp Schommers, Dae Sung Kim, Maike Schlotz, Christoph Kreer, Ralf Eggeling, Anna Hake, Melanie Stecher, Juyeon Park, Caelan E Radford, Adam S Dingens, Meryem S Ercanoglu, Henning Gruell, Stanley Odidika, Marten Dahlhaus, Lutz Gieselmann, Elvin Ahmadov, Rene Y Lawong, Eva Heger, Elena Knops, Christoph Wyen, Tim Kümmerle, Katja Römer, Stefan Scholten, Timo Wolf, Christoph Stephan, Isabelle Suárez, Nagarajan Raju, Anurag Adhikari, Stefan Esser, Hendrik Streeck, Ralf Duerr, Aubin J Nanfack, Susan Zolla-Pazner, Christof Geldmacher, Otto Geisenberger, Arne Kroidl, Wiston William, Lucas Maganga, Nyanda Elias Ntinginya, Ivelin S Georgiev, Jörg J Vehreschild, Michael Hoelscher, Gerd Fätkenheuer, Jason J Lavinder, Jesse D Bloom, Michael S Seaman, Clara Lehmann, Nico Pfeifer, George Georgiou, Florian Klein
Human immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies (nAbs) that prevent infection are the main goal of HIV vaccine discovery. But as no nAb-eliciting vaccines are yet available, only data from HIV-1 neutralizers-persons with HIV-1 who naturally develop broad and potent nAbs-can inform about the dynamics and durability of nAb responses in humans, knowledge which is crucial for the design of future HIV-1 vaccine regimens. To address this, we assessed HIV-1-neutralizing immunoglobulin G (IgG) from 2,354 persons with HIV-1 on or off antiretroviral therapy (ART)...
November 2023: Nature Medicine
https://read.qxmd.com/read/37902494/passivity-as-a-defence-and-disguised-destructiveness
#12
JOURNAL ARTICLE
Ursula Ostendorf
In this paper, I set out to describe the different viewpoints, conceptualisations and defence mechanisms of the state of passivity; the categorisation by Freud; how the perspective of his thinking was altered by later insights and clinical observations; the close connection between the superego, passivity and masochism; the significance of the internal object world for Melanie Klein; countertransference as a means of access to masochism and destructiveness, with the aid of a short case illustration; and, finally, Betty Joseph's clinical experiences in work with her patients...
October 2023: International Journal of Psycho-analysis
https://read.qxmd.com/read/37781408/15-month-post-covid-syndrome-in-outpatients-attributes-risk-factors-outcomes-and-vaccination-status-longitudinal-observational-case-control-study
#13
JOURNAL ARTICLE
Max Augustin, Melanie Stecher, Hauke Wüstenberg, Veronica Di Cristanziano, Ute Sandaradura de Silva, Lea Katharina Picard, Elisabeth Pracht, Dominic Rauschning, Henning Gruell, Florian Klein, Christoph Wenisch, Michael Hallek, Philipp Schommers, Clara Lehmann
BACKGROUND: While the short-term symptoms of post-COVID syndromes (PCS) are well-known, the long-term clinical characteristics, risk factors and outcomes of PCS remain unclear. Moreover, there is ongoing discussion about the effectiveness of post-infection vaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) to aid in PCS recovery. METHODS: In this longitudinal and observational case-control study we aimed at identifying long-term PCS courses and evaluating the effects of post-infection vaccinations on PCS recovery...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37776124/comparison-of-health-care-costs-and-resource-utilization-for-commonly-used-proteasome-inhibitor-immunomodulatory-drug-based-triplet-regimens-for-the-management-of-patients-with-relapsed-refractory-multiple-myeloma-in-the-united-states
#14
JOURNAL ARTICLE
Larysa Sanchez, Ajai Chari, Mu Cheng, Dasha Cherepanov, Maral DerSarkissian, Fei Huang, Dawn Marie Stull, Jonathan Dabora, Melanie Young, Stephen J Noga, Selina Pi, Melody Zhang, Azeem Banatwala, Mei Sheng Duh, Sikander Ailawadhi
BACKGROUND: Economic differences among currently available proteasome inhibitors (PI)-based lenalidomide-dexamethasone (Rd)-backbone triplet regimens-ixazomib (I), bortezomib (V), and carfilzomib (K) plus Rd-remain poorly understood. OBJECTIVE: To assess health care resource utilization (HCRU) and health care costs of patients with relapsed/refractory multiple myeloma (RRMM) in the United States treated with IRd, VRd, and KRd. METHODS: This retrospective longitudinal cohort study using IQVIA PharMetrics Plus adjudicated claims US data (January 1, 2015, to September 30, 2020) included adult patients with all available data who initiated IRd, VRd, or KRd in second line of therapy or later (LOT2+) on or after September 1, 2015...
September 30, 2023: Journal of Managed Care & Specialty Pharmacy
https://read.qxmd.com/read/37732180/loss-of-atp-sensitive-channel-expression-and-function-decreases-opioid-sensitivity-in-a-mouse-model-of-type-2-diabetes
#15
Cole Fisher, Kayla Johnson, Madelyn Moore, Amir Sadrati, Jody L Janecek, Melanie L Graham, Amanda H Klein
During diabetes, β-cell dysfunction due to loss of potassium channels sensitive to ATP, known as K ATP channels occurs progressively over time contributing to hyperglycemia. K ATP channels are additionally present in the central and peripheral nervous systems and are downstream targets of opioid receptor signaling. The aim of this study is to investigate if K ATP channel expression or activity in the nervous system changes in diabetic mice and if morphine antinociception changes in mice fed a high fat diet (HFD) for 16 weeks compared to controls...
September 6, 2023: bioRxiv
https://read.qxmd.com/read/37731996/carcinoid-syndrome-caused-by-a-pulmonary-carcinoid-mimics-intestinal-manifestations-of-ulcerative-colitis-a-case-report
#16
Carmen Mota Reyes, Henriette Klein, Fabian Stögbauer, Henrik Einwächter, Melanie Boxberg, Moritz Schirren, Seyer Safi, Hans Hoffmann
BACKGROUND: Pulmonary carcinoids are rare, low-grade malignant tumors characterized by neuroendocrine differentiation and relatively indolent clinical behavior. Most cases present as a slow-growing polypoidal mass in the major bronchi leading to hemoptysis and pulmonary infection due to blockage of the distal bronchi. Carcinoid syndrome is a paraneoplastic syndrome caused by the systemic release of vasoactive substances that presents in 5% of patients with neuroendocrine tumors. Due to such nonspecific presentation, most patients are misdiagnosed or diagnosed late and may receive several courses of antibiotics to treat recurrent pneumonia before the tumor is diagnosed...
September 7, 2023: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/37713293/extracellular-vesicles-and-endocannabinoid-signaling-in-patients-with-covid-19
#17
JOURNAL ARTICLE
Florian Brandes, Annekathrin M Keiler, Benedikt Kirchner, Melanie Borrmann, Jean-Noël Billaud, Marlene Reithmair, Matthias Klein, Patrizia Campolongo, Detlef Thieme, Michael W Pfaffl, Gustav Schelling, Agnes S Meidert
Introduction: Endocannabinoids in COVID-19 have immunomodulatory and anti-inflammatory properties but the functional role and the regulation of endocannabinoid signaling in this pandemic disorder is controversial. To exercise their biologic function, endocannabinoids need to travel across the intercellular space and within the blood stream to reach their target cells. How the lipophilic endocannabinoids are transported in the vascular system and how these hydrophobic compounds cross cell membranes is still unclear...
September 14, 2023: Cannabis and Cannabinoid Research
https://read.qxmd.com/read/37625924/-what-is-a-public-health-intervention-results-of-a-delphi-process-in-german-speaking-countries
#18
JOURNAL ARTICLE
Jessica Dieudonné, Lisa Jantzen, Michelle Sanwald, Michaela Trompke, Dawid Pieper, Constance Stegbauer, Gerald Willms, Barbara Buchberger, Roland Brian Büchter, Stefanie Bühn, Florian Fischer, Katharina Klein, Joseph Kuhn, Melanie Messer, Uta Wegewitz, Marlen Niederberger
BACKGROUND: Internationally, a variety of definitions for public health interventions (PHI) exist. In the German-speaking countries, however, a definition is still outstanding. Therefore, the aim of this study was to derive consensus criteria for the definition of PHI from the expert perspective of science and practice. METHODS: A Delphi survey with two online rounds was conducted from December 2022 to February 2023. Six criteria were formulated by a working group and posed for consensus: 1) the intention of the intervention, 2) potential conflicts of interest of the initiators of the intervention, 3) primary vs...
August 23, 2023: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://read.qxmd.com/read/37616558/two-phases-in-the-intervention-of-m%C3%A3-lanie-klein
#19
JOURNAL ARTICLE
Leandro Jofré
In 1930, Melanie Klein published an article presenting the case of Dick. Within the framework of the psychoanalytic technique adapted to the clinical treatment of autism, this article contributes elements to a question posed by many psychoanalysts: why did Klein's interventions affect Dick? To that end, Klein's first intervention is divided into two phases: a first naming phase, consented to by Dick; and a second interpretation phase, triggering detachment from the object, anxiety, and stereotypy. The proposal is to understand the emergence of anxiety in the relationship that the second-phase interpretation has with the first phase of naming...
August 24, 2023: Psychoanalytic Quarterly
https://read.qxmd.com/read/37607785/role-of-fatty-liver-in-the-epidemic-of-advanced-chronic-liver-disease-among-people-with-hiv-protocol-for-the-canadian-livehiv-multicentre-prospective-cohort
#20
JOURNAL ARTICLE
Felice Cinque, Sahar Saeed, Dana Kablawi, Luz Ramos Ballesteros, Wesal Elgretli, Erica E M Moodie, Colleen Price, Ken Monteith, Curtis Cooper, Sharon L Walmsley, Neora Pick, Melanie C M Murray, Joseph Cox, Nadine Kronfli, Cecilia T Costiniuk, Alexandra de Pokomandy, Jean-Pierre Routy, Bertrand Lebouché, Marina B Klein, Giada Sebastiani
INTRODUCTION: Advanced chronic liver disease (ACLD) is a major cause of death for people with HIV (PWH). While viral hepatitis coinfections are largely responsible for this trend, metabolic dysfunction-associated steatotic liver disease (MASLD) is an emerging concern for PWH. We aimed to assess the contribution of MASLD to incident ACLD in PWH. METHODS AND ANALYSIS: This multicentre prospective observational cohort study will enrol 968 consecutive HIV monoinfected patients from four Canadian sites, excluding subjects with alcohol abuse, liver disease other than MASLD, or ACLD at baseline...
August 22, 2023: BMJ Open
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