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https://www.readbyqxmd.com/read/28426281/identification-of-ssea-1-expressing-enhanced-reprogramming-seer-cells-in-porcine-embryonic-fibroblasts
#1
Dong Li, Jan O Secher, Morten Juhl, Kaveh Mashayekhi, Troels T Nielsen, Bjørn Holst, Poul Hyttel, Kristine K Freude, Vanessa J Hall
Previous research has shown that a subpopulation of cells within cultured human dermal fibroblasts, termed multilineage-differentiating stress enduring (Muse) cells, are preferentially reprogrammed into induced pluripotent stem cells. However, controversy exists over whether these cells are the only cells capable of being reprogrammed from a heterogeneous population of fibroblasts. Similarly, there is little research to suggest such cells may exist in embryonic tissues or other species. In order to address if such a cell population exists in pigs, we investigated porcine embryonic fibroblast populations (pEFs) and identified heterogeneous expression of several key cell surface markers...
April 20, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28406508/integration-of-digital-microfluidics-with-whispering-gallery-mode-sensors-for-label-free-detection-of-biomolecules
#2
Sentayehu F Wondimu, Sebastian von der Ecken, Ralf Ahrens, Wolfgang Freude, Andreas E Guber, Christian Koos
We present a multi-sensor chip comprising an array of whispering-gallery mode (WGM) micro-goblet lasers integrated into a digital microfluidic (DMF) system. In contrast to earlier demonstrations, the lasers are fabricated from dye-doped poly-methyl methacrylate (PMMA) at low cost using spin-coating, mask-based optical lithography, wet chemical etching, and thermal reflow techniques. Pumping and read-out of the devices is accomplished via simple free-space optics, thereby allowing large-scale sensor arrays to be addressed...
April 13, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28403200/identification-of-potential-biomarkers-in-donor-cows-for-in-vitro-embryo-production-by-granulosa-cell-transcriptomics
#3
Gianluca Mazzoni, Suraya M Salleh, Kristine Freude, Hanne S Pedersen, Lotte Stroebech, Henrik Callesen, Poul Hyttel, Haja N Kadarmideen
The Ovum Pick Up-In vitro Production (OPU-IVP) of embryos is an advanced reproductive technology used in cattle production but the complex biological mechanisms behind IVP outcomes are not fully understood. In this study we sequenced RNA of granulosa cells collected from Holstein cows at oocyte aspiration prior to IVP, to identify candidate genes and biological mechanisms for favourable IVP-related traits in donor cows where IVP was performed separately for each animal. We identified 56 genes significantly associated with IVP scores (BL rate, kinetic and morphology)...
2017: PloS One
https://www.readbyqxmd.com/read/28396671/modeling-human-natural-killer-cell-development-in-the-era-of-innate-lymphoid-cells
#4
Steven D Scoville, Aharon G Freud, Michael A Caligiuri
Decades after the discovery of natural killer (NK) cells, their developmental pathways in mice and humans have not yet been completely deciphered. Accumulating evidence indicates that NK cells can develop in multiple tissues throughout the body. Moreover, detailed and comprehensive models of NK cell development were proposed soon after the turn of the century. However, with the recent identification and characterization of other subtypes of innate lymphoid cells (ILCs), which show some overlapping functional and phenotypic features with NK cell developmental intermediates, the distinct stages through which human NK cells develop from early hematopoietic progenitor cells remain unclear...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28373655/the-cut-and-the-building-of-psychoanalysis-volume-i-sigmund-freud-and-emma-eckstein-by-carlo-bonomi-routledge-sussex-and-new-york-2015-288pp
#5
Judith E Vida
No abstract text is available yet for this article.
April 3, 2017: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28373652/the-cut-and-the-building-of-psychoanalysis-volume-1-sigmund-freud-and-emma-eckstein-by-carlo-bonomi-routledge-sussex-and-new-york-288pp
#6
Aleksandar Dimitrijevic
No abstract text is available yet for this article.
April 3, 2017: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28366897/revolutionizing-cuban-psychiatry-the-freud-wars-1955-1970
#7
Jennifer Lynn Lambe
This article traces the battle over Freud within Cuban psychiatry from its pre-1959 origins through the "disappearance" of Freud by the early 1970s. It devotes particular attention to the visit of two Soviet psychiatrists to Cuba in the early 1960s as part of a broader campaign to promote Pavlov. The decade-long controversy over Freud responded to both theoretical and political concerns. If for some Freud represented political conservatism and theoretical mystification, Pavlov held out the promise of a dialectical materialist future...
2017: Bulletin of the History of Medicine
https://www.readbyqxmd.com/read/28359364/age-dependent-risk-factors-for-malnutrition-in-traumatology-and%C3%A2-orthopedic-patients
#8
Christine Lambert, Andreas Nüssler, Hans Konrad Biesalski, Thomas Freude, Christian Bahrs, Gunnar Ochs, Ingo Flesch, Ulrich Stöckle, Christoph Ihle
OBJECTIVE: The aim of this study was to investigate the prevalence of risk of malnutrition (RoM) in an orthopedic and traumatology patient cohort with a broad range of ages. In addition to the classical indicators for risk assessment (low body mass index, weight loss, and comorbidity), this study aimed to analyze the effects of lifestyle factors (eating pattern, smoking, physical activity) on RoM. METHODS: The prospective cohort study included 1053 patients in a level 1 trauma center in Germany...
May 2017: Nutrition
https://www.readbyqxmd.com/read/28348414/the-cut-and-the-building-of-psychoanalysis-volume-1-sigmund-freud-and-emma-eckstein-by-carlo-bonomi-routledge-sussex-new-york-2015-288pp
#9
Louis Rothschild
No abstract text is available yet for this article.
March 27, 2017: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28332712/-for-beauty-is-nothing-but-the-barely-endurable-onset-of-terror-outline-of-a-general-psychoanalytic-aesthetics
#10
Sebastian Leikert
Even close to 80 years after Freud's words that psychoanalysis "has scarcely anything to say about beauty" (Freud, Civilization and its Discontents, SE 21, p. 82) the question of a specific psychoanalytic aesthetic is still faced with a deficit in theory. Since aesthetics is related to Aisthesis, the Greek word for 'perception', a psychoanalytic aesthetic can solely emerge from a psychoanalysis of perceptive structures. The term 'kinaesthetic semantic' is introduced in order to exemplify via music how perceptive experiences must be structured for them to be experienced as beautiful...
March 23, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28327300/rbaltmip-a-recombinant-alpha-type-myotoxin-inhibitor-from-bothrops-alternatus-rhinocerophis-alternatus-snake-as-a-potential-candidate-to-complement-the-antivenom-therapy
#11
Norival A Santos-Filho, Tiago S Sousa, Johara Boldrini-França, Ludier K Santos-Silva, Danilo L Menaldo, Flávio Henrique-Silva, Adélia C O Cintra, Helen J Laure, Carla C N Mamede, Fábio Oliveira, Thalita B Riul, Marcelo Dias-Baruffi, José C Rosa, Suely V Sampaio
Phospholipase A2 inhibitors (PLIs) are important targets in the search and development of new drugs. This study aimed at evaluating the potential of an alpha-type phospholipase A2 inhibitor from Bothrops alternatus (Rhinocerophis alternatus) snake in its recombinant form (rBaltMIP) to complement the conventional antivenom therapy. Biochemical experiments showed that rBaltMIP presented pI 5.8 and molecular masses of ∼21 kDa by SDS-PAGE and 19.57 kDa by MALDI/TOF MS. After tryptic peptides sequencing, the results were compared with other PLIs available in databases, showing 100% identity between rBaltMIP and its native inhibitor BaltMIP and from 92% to 96% identity with other inhibitors...
December 15, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28322165/anti-inflammatory-and-anti-arthritic-activity-of-different-milk-based-formulation-of-curcumin-in-rat-model
#12
Sumeet Gupta
Inflammation is the key mediator for arthritis. Plant based products are most useful for treating various disorders, but at the same time drug absorbtion is utmost important for effective therapy. The aim of the study was to find out the therapeutic concern in pharmacokinetic and pharmacodynamic parameters in an arthritis induced rat model. Carrageenan and complete Freud's adjuvant, both were used for an arthritis induction as an animal model. Five different formulations of curcumin were prepared in single toned milk, double toned milk, full fat milk, full fat milk with ghee and in an aqueous suspension...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28278058/the-queerness-of-the-drive
#13
Teresa de Lauretis
The view of sexuality Freud first proposed in the Three Essays on the Theory of Sexuality contains a discrepancy between the sexuality perverse and polymorphous described in the first two essays and the biologically directed, reproductive sexuality of the third essay. According to Jean Laplanche, the theorist of psychoanalysis who is Freud's closest reader and translator, the discrepancy is due to two contradictory opinions Freud apparently held at different moments of his writing: one, that sexuality is exogenous, an effect of seduction by adults; two, that sexuality is endogenous, innate in the human biological organism...
February 16, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28275347/cognitive-training-sustainably-improves-executive-functioning-in-middle-aged-industry-workers-assessed-by-task-switching-a-randomized-controlled-erp-study
#14
Patrick D Gajewski, Gabriele Freude, Michael Falkenstein
Recently, we reported results of a cross-sectional study investigating executive functions in dependence of aging and type of work. That study showed deficits in performance and electrophysiological activity in middle-aged workers with long-term repetitive and unchallenging work. Based on these findings, we conducted a longitudinal study that aimed at ameliorating these cognitive deficits by means of a trainer-guided cognitive training (CT) in 57 further middle-aged workers with repetitive type of work from the same factory...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28272829/freud-and-the-scene-of-trauma-by-john-fletcher
#15
Ira Brenner
No abstract text is available yet for this article.
January 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/28272824/ten-short-essays-on-how-trauma-is-inextricably-woven-into-psychic-life
#16
Dominique Scarfone
The author contends that it is possible to reconcile trauma and drive theories of psychopathology if we carefully examine the general notion of trauma and reexamine Freud's () theory of war neurosis and of repression itself as an elementary form of traumatic neurosis. The logic of these views follows Laplanche's reintroduction and generalization of the seduction theory in contemporary psychoanalysis.
January 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/28272820/freud-and-war-edited-by-marlene-belilos
#17
Aaron H Esman
No abstract text is available yet for this article.
January 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/28272818/a-model-for-integrating-actual-neurotic-or-unrepresented-states-and-symbolized-aspects-of-intrapsychic-conflict
#18
Fredric N Busch
In psychoanalytic theory, the importance of actual neuroses-considered to be devoid of psychic content-diminished as Freud and subsequent analysts focused on unconscious intrapsychic conflict. This paper explores the relationship between actual neurotic and unrepresented states, which are believed to be best addressed through attention to countertransference, intersubjectivity, and enactments rather than interpretation of intrapsychic conflict. Models suggesting how actual neurotic states and symbolized intrapsychic conflict may interact with each other and environmental stressors are described...
January 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/28265351/elevated-axonal-membrane-permeability-and-its-correlation-with-motor-deficits-in-an-animal-model-of-multiple-sclerosis
#19
Gary Leung, Melissa Tully, Jonathan Tang, Shengxi Wu, Riyi Shi
BACKGROUND: It is increasingly clear that in addition to myelin disruption, axonal degeneration may also represent a key pathology in multiple sclerosis (MS). Hence, elucidating the mechanisms of axonal degeneration may not only enhance our understanding of the overall MS pathology, but also elucidate additional therapeutic targets. The objective of this study is assess the degree of axonal membrane disruption and its significance in motor deficits in EAE mice. METHODS: Experimental Autoimmune Encephalomyelitis was induced in mice by subcutaneous injection of myelin oligodendrocyte glycoprotein/complete Freud's adjuvant emulsion, followed by two intraperitoneal injections of pertussis toxin...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28261798/early-and-deep-two-independent-paradigms
#20
Martine Girard
Did Winnicott replace or transform Freud's metapsychology? The author's aim is to explore more deeply the views developed in a previous paper based solely on Winnicott. Here the author draws on other studies to respond to two questions recently posed by Fulgencio concerning the meaning of the term metapsychology and the existence of a new topography in Winnicott's work. For many authors, Winnicott does not reject Freudian metapsychology and says nothing new in this field; in the field of paediatric anthropology, however, he focuses on dependence, and in the field of the living embodiment of the drives on being and self as different from ego...
March 6, 2017: International Journal of Psycho-analysis
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