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https://www.readbyqxmd.com/read/28044390/systematic-in-vitro-and-in-vivo-characterization-of-leukemia-inhibiting-factor-and-fibroblast-growth-factor-derived-porcine-induced-pluripotent-stem-cells
#1
Jan O Secher, Ahmet Ceylan, Gianluca Mazzoni, Kaveh Mashayekhi, Tong Li, Suchitra Muenthaisong, Troels T Nielsen, Dong Li, Shengting Li, Stoyan Petkov, Susanna Cirera, Yonglun Luo, Lori Thombs, Haja N Kadarmideen, Andras Dinnyes, Lars Bolund, Bernard A J Roelen, Mette Schmidt, Henrik Callesen, Poul Hyttel, Kristine K Freude
Derivation and stable maintenance of porcine induced pluripotent stem cells (piPSCs) is challenging. We herein systematically analyzed two piPSC lines, derived by lentiviral transduction and cultured under either leukemia inhibitory factor (LIF) or fibroblast growth factor (FGF) conditions, to shed more light on the underlying biological mechanisms of porcine pluripotency. LIF-derived piPSCs were more successful than their FGF-derived counterparts in the generation of in vitro chimeras and in teratoma formation...
January 3, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28038888/biologic-drug-survival-in-israeli-psoriasis-patients
#2
Guy Shalom, Arnon D Cohen, Michael Ziv, Cohen Barak Eran, Ilan Feldhamer, Tamar Freud, Eitan Berman, Shirley Oren, Emmilia Hodak, Lev Pavlovsky
BACKGROUND: Drug survival is defined as the time period of treatment with a certain drug until its cessation. The role of previous exposure to traditional systemic treatments in biologic survival is still unknown. OBJECTIVE: To investigate the drug survival rates of biologic treatments in patients with psoriasis and to identify predictor factors. METHODS: Survival analysis was performed on patients with severe psoriasis who received adalimumab, infliximab, etanercept, and ustekinumab for treatment of psoriasis, drawn from the Clalit Health Services database...
December 28, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28018799/caudal-duplication-syndrome-the-vital-role-of-a-multidisciplinary-approach-and-staged-correction
#3
Inbal Samuk, Marc Levitt, Elena Dlugy, Dragan Kravarusic, David Ben-Meir, Gustavo Rajz, Osnat Konen, Enrique Freud
Caudal duplication syndrome is a rare entity that describes the association between congenital anomalies involving caudal structures and may have a wide spectrum of clinical manifestations. A full-term male presented with combination of anomalies including anorectal malformation, duplication of the colon and lower urinary tract, split of the lower spine, and lipomyelomeningocele with tethering of the cord. We report this exceptional case of caudal duplication syndrome with special emphasis on surgical strategy and approach combining all disciplines involved...
December 2016: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/28006753/agmatine-ameliorates-adjuvant-induced-arthritis-and-inflammatory-cachexia-in-rats
#4
Brijesh G Taksande, Dinesh Y Gawande, Chandrabhan T Chopde, Milind J Umekar, Nandkishor R Kotagale
The present study investigated the pharmacological effect of agmatine in Complete Freud Adjuvant (CFA) induced arthritis and cachexia in rats. The rats were injected with CFA (0.1ml/rat) to induced symptoms of arthritis. Day 8 onwards of CFA administration, rats were injected daily with agmatine for next 7days, and arthritis score, body weights and food intake were monitored daily (g). Since cachexia is known to produce severe inflammation, malnutrition and inhibition of albumin gene expression, we have also monitored the total proteins, albumin, TNF-α and IL-6 levels in arthritic rats and its modulation by agmatine...
December 19, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27984062/rbaltmip-a-recombinant-alpha-type-myotoxin-inhibitor-from-bothrops-alternatus-rhinocerophis-alternatus-snake-as-a-potential-candidate-to-complement-the-antivenom-therapy
#5
Norival A Santos-Filho, Tiago S Sousa, Johara Boldrini-França, Ludier K Santos-Silva, Danilo L Menaldo, Flávio Henrique-Silva, Adélia C O Cintra, Helen J Laure, Carla C N Mamede, Fábio de Oliveira, Thalita B Riul, Marcelo Dias-Baruffi, José C Rosa, Suely V Sampaio
Phospholipase A2 inhibitors (PLIs) are important targets in the search and development of new drugs. This study aimed at evaluating the potential of an alpha-type phospholipase A2 inhibitor from Bothrops alternatus (Rhinocerophis alternatus) snake in its recombinant form (rBaltMIP) to complement the conventional antivenom therapy. Biochemical experiments showed that rBaltMIP presented pI 5.8 and molecular masses of ∼21 kDa by SDS-PAGE and 19.57 kDa by MALDI/TOF MS. After tryptic peptides sequencing, the results were compared with other PLIs available in databases, showing 100% identity between rBaltMIP and its native inhibitor BaltMIP and from 92% to 96% identity with other inhibitors...
October 28, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27975362/-religiosity-and-mental-health
#6
Raphael Maria Bonelli
Since 1978, two systematic evidence-based reviews of the available data on religiosity and mental health in the field of psychiatry have been done. More than 70 % found a relationship between level of religious/spiritual involvement and less mental disorder (positive), some found mixed results (positive and negative), and only about 5 % reported more mental disorder (negative), as was originally suggested by Sigmund Freud. There is good evidence that religious involvement is correlated with better mental health in the areas of depression, substance abuse, and suicide; some evidence in stress-related disorders and dementia; insufficient evidence in bipolar disorder and schizophrenia, and no data in many other mental disorders...
December 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27966795/the-so-called-death-drive-an-indispensable-force-for-any-subjective-life
#7
Bernard Penot
The psychoanalytic movement has difficulty in overcoming the malaise bequeathed by what Freud wanted to call the 'death drive'. This term remains doubly problematic: first because the indispensable antagonist of Eros-binding cannot be reduced to a particular drive; and secondly because this Anteros plays a vital role in subjectivization. The Freudian idea of the 'death drive' has in addition the drawback of confusing dissociative thrust (unbinding) with the aggressive component of libidinal cathexis. Now it is precisely the lack of articulation between them that leads to deconstructing it...
December 14, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27943278/frequency-and-clinical-correlates-of-elevated-plasma-epstein-barr-virus-dna-at-diagnosis-in-peripheral-t-cell-lymphomas-ptcl
#8
Bradley M Haverkos, Ying Huang, Alejandro Gru, Preeti Pancholi, Aharon G Freud, Anjali Mishra, Amy S Ruppert, Robert A Baiocchi, Pierluigi Porcu
Epstein Barr virus (EBV)-encoded RNAs (EBER) in tumor tissue and cell-free plasma EBV-DNA (pEBVd) are detected in EBV-associated lymphomas. Studies have suggested that EBER+ peripheral T-cell lymphomas (PTCL) have worse prognosis but the role of EBV in these neoplasms remains unclear. pEBVd is quantitative and more easily amenable to standardization than EBER, but frequency of pEBVd detection, clinical impact, and agreement with EBER status in PTCL are unknown. We retrospectively assessed frequency of detectable pre-treatment pEBVd, presence of EBER in tumor tissue, and outcomes in 61 of 135 EBV-assessable PTCL patients...
December 10, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27934604/generation-of-induced-pluripotent-stem-cells-ipscs-stably-expressing-crispr-based-synergistic-activation-mediator-sam
#9
Kai Xiong, Yan Zhou, Poul Hyttel, Lars Bolund, Kristine Karla Freude, Yonglun Luo
Human fibroblasts were engineered to express the CRISPR-based synergistic activation mediator (SAM) complex: dCas9-VP64 and MS2-P65-HSF1. Two induced pluripotent stem cells (iPSCs) clones expressing SAM were established by transducing these fibroblasts with lentivirus expressing OCT4, SOX2, KLF4 and C-MYC. We have validated that the reprogramming cassette is silenced in the SAM iPSC clones. Expression of pluripotency genes (OCT4, SOX2, LIN28A, NANOG, GDF3, SSEA4, and TRA-1-60), differentiation potential to all three germ layers, and normal karyotypes are validated...
November 17, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27914010/recruitment-by-the-repressor-freud-1-of-histone-deacetylase-brg1-chromatin-remodeling-complexes-to-strengthen-htr1a-gene-repression
#10
Tatiana Souslova, Kim Mirédin, Anne M Millar, Paul R Albert
Five-prime repressor element under dual repression binding protein-1 (Freud-1)/CC2D1A is genetically linked to intellectual disability and implicated in neuronal development. Freud-1 represses the serotonin-1A (5-HT1A) receptor gene HTR1A by histone deacetylase (HDAC)-dependent or HDAC-independent mechanisms in 5-HT1A-negative (e.g., HEK-293) or 5-HT1A-expressing cells (SK-N-SH), respectively. To identify the underlying mechanisms, Freud-1-associated proteins were affinity-purified from HEK-293 nuclear extracts and members of the Brg1/SMARCCA chromatin remodeling and Sin3A-HDAC corepressor complexes were identified...
December 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27899730/varieties-of-fame-in-psychology
#11
Henry L Roediger
Fame in psychology, as in all arenas, is a local phenomenon. Psychologists (and probably academics in all fields) often first become well known for studying a subfield of an area (say, the study of attention in cognitive psychology, or even certain tasks used to study attention). Later, the researcher may become famous within cognitive psychology. In a few cases, researchers break out of a discipline to become famous across psychology and (more rarely still) even outside the confines of academe. The progression is slow and uneven...
November 2016: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/27893462/biallelic-mutations-in-irf8-impair-human-nk-cell-maturation-and-function
#12
Emily M Mace, Venetia Bigley, Justin T Gunesch, Ivan K Chinn, Laura S Angelo, Matthew A Care, Sheetal Maisuria, Michael D Keller, Sumihito Togi, Levi B Watkin, David F LaRosa, Shalini N Jhangiani, Donna M Muzny, Asbjørg Stray-Pedersen, Zeynep Coban Akdemir, Jansen B Smith, Mayra Hernández-Sanabria, Duy T Le, Graham D Hogg, Tram N Cao, Aharon G Freud, Eva P Szymanski, Sinisa Savic, Matthew Collin, Andrew J Cant, Richard A Gibbs, Steven M Holland, Michael A Caligiuri, Keiko Ozato, Silke Paust, Gina M Doody, James R Lupski, Jordan S Orange
Human NK cell deficiencies are rare yet result in severe and often fatal disease, particularly as a result of viral susceptibility. NK cells develop from hematopoietic stem cells, and few monogenic errors that specifically interrupt NK cell development have been reported. Here we have described biallelic mutations in IRF8, which encodes an interferon regulatory factor, as a cause of familial NK cell deficiency that results in fatal and severe viral disease. Compound heterozygous or homozygous mutations in IRF8 in 3 unrelated families resulted in a paucity of mature CD56dim NK cells and an increase in the frequency of the immature CD56bright NK cells, and this impairment in terminal maturation was also observed in Irf8-/-, but not Irf8+/-, mice...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27883293/psychological-mislabeling-of-chronic-pain-lessons-from-migraine-in-the-20th-century
#13
Howard B Pikoff
Starting with Freud, psychoanalytically oriented practitioners described a complex of unconscious conflicts, desires and personality traits they believed to be the primary cause of a wide range of medical disorders. This was the psychogenic model. With the advance of basic research and pharmacotherapy, the psychogenic model was gradually replaced by a biopsychobehavioral model. This model treats chronic pain as a biologically based disorder that can be influenced by psychological factors and lifestyle. The present paper argues that many patients with chronic pain may not be significantly impacted by psychological factors, and that for those who are, cognitive-behavioral therapy is the treatment of choice...
November 24, 2016: Pain Management
https://www.readbyqxmd.com/read/27880736/experimental-validation-of-a-multi-energy-x-ray-adapted-scatter-separation-method
#14
A Sossin, V Rebuffel, J Tabary, J M Létang, N Freud, L Verger
Both in radiography and computed tomography (CT), recently emerged energy-resolved x-ray photon counting detectors enable the identification and quantification of individual materials comprising the inspected object. However, the approaches used for these operations require highly accurate x-ray images. The accuracy of the images is severely compromised by the presence of scattered radiation, which leads to a loss of spatial contrast and, more importantly, a bias in radiographic material imaging and artefacts in CT...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27879212/generation-of-a-gene-corrected-isogenic-control-cell-line-from-an-alzheimer-s-disease-patient-ipsc-line-carrying-a-a79v-mutation-in-psen1
#15
Carlota Pires, Benjamin Schmid, Carina Petræus, Anna Poon, Natakarn Nimsanor, Troels T Nielsen, Gunhild Waldemar, Lena E Hjermind, Jørgen E Nielsen, Poul Hyttel, Kristine K Freude
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease causing neural cell degeneration and brain atrophy and is considered to be the most common form of dementia. We previously generated an induced pluripotent stem cell (iPSC) line from an AD patient carrying an A79V mutation in PSEN1 as an in vitro disease model. Here we generated a gene-corrected version from this hiPSC line by substituting the point mutation with the wild-type sequence. The reported A79V-GC-iPSCs line is a very useful resource in combination with the A79V-iPSC line in order to study pathological cellular phenotypes related to this particular mutation...
September 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27861831/freud-s-paternity-crises
#16
Edward A Jones
This article reexamines the interpretation of the significance of the Aliquis slip and related materials in terms of a family crisis in 1900 involving Freud, Anna Freud Bernays and their youngest sister Paula. It contends that Ernest Jones and Anna Freud later hid this story from history, largely for family reasons. It supports this contention by drawing on Ernest Jones and Anna Freud's archived letters, Anna Freud Bernays' memoirs, the complete Freud-Fliess letters and other historical sources and compares them to The Origins of Psychoanalysis and to Ernest Jones' biography of Freud...
November 14, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27859180/infantile-anorexia-co-excitation-and-co-mastery-in-the-parent-baby-cathexis-the-contribution-of-sigmund-and-anna-freud
#17
Thomas Cascales
Recent epidemiological studies show that 2% of babies in ordinary paediatric clinics suffer from infantile anorexia. In the first part of this paper we present a case study from our hospital clinical activity. Our framework combines clinical psychoanalytic sessions and perinatal videos. In the second part, we will focus on the concepts of instinct and excitation proposed by Sigmund Freud and the concept of mastery proposed by Anna Freud. In the third part, we will examine these concepts in the light of the case study...
November 17, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27859179/revisiting-the-destiny-compulsion
#18
Anna Potamianou
This paper is an attempt to deal with some questions raised by the so-called 'compulsion of destiny' constellation. In presenting the standpoints of Freud and of psychoanalysts who after him were concerned with this problematic, the author takes the view that several aspects of the configuration merit further discussion. Accordingly, the dynamics of repetition compulsion, the complexity of the projective strategy, the coexistence of passive and omnipotent trends are considered. Concerning compulsive repetitions the dimension of drive intrication is underlined, thus moderating the understanding of this clinical entity as mainly related to death drive trends...
November 17, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27859149/psyche-and-culture-perspectives-based-on-the-contributions-and-limits-of-ethnopsychiatry
#19
Rajaa Stitou
The unconscious often appears in the form of a question or answer to the difficult relationship between the psyche and culture, a difficulty that becomes exacerbated when we are dealing with cultural difference. This difficulty, evidenced for example by Freud's thoughts on Islam, reappears, albeit in a very different way, in ethnopsychiatric theory. The author discusses the blind spots of the binary logic of the unconscious present in the work of George Devereux, a logic that eventually leads him into the same trap he had himself criticized...
December 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27855423/manic-defences-in-contemporary-society-the-psychocultural-approach
#20
Dusko Rudan, Miro Jakovljevic, Darko Marcinko
The article discusses the impact of contemporary culture on the individual's personality. We used the "psychocultural" approach whose key feature is the amalgamation of theories and methods belonging to psychodynamic and psychosocial studies, as well as those used in the field of media and cultural studies. The idea of a potentially therapeutic effect of culture (therapy culture) can already been seen in Freud's and Lacan's texts, and it is often used in critical analyses of contemporary corporate culture, which is more or less developed in some parts of the world...
December 2016: Psychiatria Danubina
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