keyword
MENU ▼
Read by QxMD icon Read
search

Freud

keyword
https://www.readbyqxmd.com/read/27914010/recruitment-by-the-repressor-freud-1-of-histone-deacetylase-brg1-chromatin-remodeling-complexes-to-strengthen-htr1a-gene-repression
#1
Tatiana Souslova, Kim Mirédin, Anne M Millar, Paul R Albert
Five-prime repressor element under dual repression binding protein-1 (Freud-1)/CC2D1A is genetically linked to intellectual disability and implicated in neuronal development. Freud-1 represses the serotonin-1A (5-HT1A) receptor gene HTR1A by histone deacetylase (HDAC)-dependent or HDAC-independent mechanisms in 5-HT1A-negative (e.g., HEK-293) or 5-HT1A-expressing cells (SK-N-SH), respectively. To identify the underlying mechanisms, Freud-1-associated proteins were affinity-purified from HEK-293 nuclear extracts and members of the Brg1/SMARCCA chromatin remodeling and Sin3A-HDAC corepressor complexes were identified...
December 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27899730/varieties-of-fame-in-psychology
#2
Henry L Roediger
Fame in psychology, as in all arenas, is a local phenomenon. Psychologists (and probably academics in all fields) often first become well known for studying a subfield of an area (say, the study of attention in cognitive psychology, or even certain tasks used to study attention). Later, the researcher may become famous within cognitive psychology. In a few cases, researchers break out of a discipline to become famous across psychology and (more rarely still) even outside the confines of academe. The progression is slow and uneven...
November 2016: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/27893462/biallelic-mutations-in-irf8-impair-human-nk-cell-maturation-and-function
#3
Emily M Mace, Venetia Bigley, Justin T Gunesch, Ivan K Chinn, Laura S Angelo, Matthew A Care, Sheetal Maisuria, Michael D Keller, Sumihito Togi, Levi B Watkin, David F LaRosa, Shalini N Jhangiani, Donna M Muzny, Asbjørg Stray-Pedersen, Zeynep Coban Akdemir, Jansen B Smith, Mayra Hernández-Sanabria, Duy T Le, Graham D Hogg, Tram N Cao, Aharon G Freud, Eva P Szymanski, Sinisa Savic, Matthew Collin, Andrew J Cant, Richard A Gibbs, Steven M Holland, Michael A Caligiuri, Keiko Ozato, Silke Paust, Gina M Doody, James R Lupski, Jordan S Orange
Human NK cell deficiencies are rare yet result in severe and often fatal disease, particularly as a result of viral susceptibility. NK cells develop from hematopoietic stem cells, and few monogenic errors that specifically interrupt NK cell development have been reported. Here we have described biallelic mutations in IRF8, which encodes an interferon regulatory factor, as a cause of familial NK cell deficiency that results in fatal and severe viral disease. Compound heterozygous or homozygous mutations in IRF8 in 3 unrelated families resulted in a paucity of mature CD56dim NK cells and an increase in the frequency of the immature CD56bright NK cells, and this impairment in terminal maturation was also observed in Irf8-/-, but not Irf8+/-, mice...
November 28, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27883293/psychological-mislabeling-of-chronic-pain-lessons-from-migraine-in-the-20th-century
#4
Howard B Pikoff
Starting with Freud, psychoanalytically oriented practitioners described a complex of unconscious conflicts, desires and personality traits they believed to be the primary cause of a wide range of medical disorders. This was the psychogenic model. With the advance of basic research and pharmacotherapy, the psychogenic model was gradually replaced by a biopsychobehavioral model. This model treats chronic pain as a biologically based disorder that can be influenced by psychological factors and lifestyle. The present paper argues that many patients with chronic pain may not be significantly impacted by psychological factors, and that for those who are, cognitive-behavioral therapy is the treatment of choice...
November 24, 2016: Pain Management
https://www.readbyqxmd.com/read/27880736/experimental-validation-of-a-multi-energy-x-ray-adapted-scatter-separation-method
#5
A Sossin, V Rebuffel, J Tabary, J M Létang, N Freud, L Verger
Both in radiography and computed tomography (CT), recently emerged energy-resolved x-ray photon counting detectors enable the identification and quantification of individual materials comprising the inspected object. However, the approaches used for these operations require highly accurate x-ray images. The accuracy of the images is severely compromised by the presence of scattered radiation, which leads to a loss of spatial contrast and, more importantly, a bias in radiographic material imaging and artefacts in CT...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27879212/generation-of-a-gene-corrected-isogenic-control-cell-line-from-an-alzheimer-s-disease-patient-ipsc-line-carrying-a-a79v-mutation-in-psen1
#6
Carlota Pires, Benjamin Schmid, Carina Petræus, Anna Poon, Natakarn Nimsanor, Troels T Nielsen, Gunhild Waldemar, Lena E Hjermind, Jørgen E Nielsen, Poul Hyttel, Kristine K Freude
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease causing neural cell degeneration and brain atrophy and is considered to be the most common form of dementia. We previously generated an induced pluripotent stem cell (iPSC) line from an AD patient carrying an A79V mutation in PSEN1 as an in vitro disease model. Here we generated a gene-corrected version from this hiPSC line by substituting the point mutation with the wild-type sequence. The reported A79V-GC-iPSCs line is a very useful resource in combination with the A79V-iPSC line in order to study pathological cellular phenotypes related to this particular mutation...
September 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27861831/freud-s-paternity-crises
#7
Edward A Jones
This article reexamines the interpretation of the significance of the Aliquis slip and related materials in terms of a family crisis in 1900 involving Freud, Anna Freud Bernays and their youngest sister Paula. It contends that Ernest Jones and Anna Freud later hid this story from history, largely for family reasons. It supports this contention by drawing on Ernest Jones and Anna Freud's archived letters, Anna Freud Bernays' memoirs, the complete Freud-Fliess letters and other historical sources and compares them to The Origins of Psychoanalysis and to Ernest Jones' biography of Freud...
November 14, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27859180/infantile-anorexia-co-excitation-and-co-mastery-in-the-parent-baby-cathexis-the-contribution-of-sigmund-and-anna-freud
#8
Thomas Cascales
Recent epidemiological studies show that 2% of babies in ordinary paediatric clinics suffer from infantile anorexia. In the first part of this paper we present a case study from our hospital clinical activity. Our framework combines clinical psychoanalytic sessions and perinatal videos. In the second part, we will focus on the concepts of instinct and excitation proposed by Sigmund Freud and the concept of mastery proposed by Anna Freud. In the third part, we will examine these concepts in the light of the case study...
November 17, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27859179/revisiting-the-destiny-compulsion
#9
Anna Potamianou
This paper is an attempt to deal with some questions raised by the so-called 'compulsion of destiny' constellation. In presenting the standpoints of Freud and of psychoanalysts who after him were concerned with this problematic, the author takes the view that several aspects of the configuration merit further discussion. Accordingly, the dynamics of repetition compulsion, the complexity of the projective strategy, the coexistence of passive and omnipotent trends are considered. Concerning compulsive repetitions the dimension of drive intrication is underlined, thus moderating the understanding of this clinical entity as mainly related to death drive trends...
November 17, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27859149/psyche-and-culture-perspectives-based-on-the-contributions-and-limits-of-ethnopsychiatry
#10
Rajaa Stitou
The unconscious often appears in the form of a question or answer to the difficult relationship between the psyche and culture, a difficulty that becomes exacerbated when we are dealing with cultural difference. This difficulty, evidenced for example by Freud's thoughts on Islam, reappears, albeit in a very different way, in ethnopsychiatric theory. The author discusses the blind spots of the binary logic of the unconscious present in the work of George Devereux, a logic that eventually leads him into the same trap he had himself criticized...
November 17, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27855423/manic-defences-in-contemporary-society-the-psychocultural-approach
#11
Dusko Rudan, Miro Jakovljevic, Darko Marcinko
The article discusses the impact of contemporary culture on the individual's personality. We used the "psychocultural" approach whose key feature is the amalgamation of theories and methods belonging to psychodynamic and psychosocial studies, as well as those used in the field of media and cultural studies. The idea of a potentially therapeutic effect of culture (therapy culture) can already been seen in Freud's and Lacan's texts, and it is often used in critical analyses of contemporary corporate culture, which is more or less developed in some parts of the world...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27845617/bereavement-an-anthropological-approach
#12
Margaret Souza
The literature on bereavement has been dominated by psychology (Bowlby, 1969; Freud, 1961 ; Parkes, 1972 ; Worden, 1991 ). Social Science (Hockey et al., 2001 ; Klass, Silverman, & Nickman, 1996; Valentine, 2008 ; Walter, 1999 ) has expanded that perspective by illustrating the ways in which the bereaved maintain continuing bonds with the deceased. In this article I build upon the social science literature from an anthropological perspective. I focus upon how the bereaved must learn to live in the social environment without the deceased in what I call a "new normal...
November 15, 2016: Death Studies
https://www.readbyqxmd.com/read/27828482/multi-wavelength-coherent-transmission-using-an-optical-frequency-comb-as-a-local-oscillator
#13
Juned N Kemal, Joerg Pfeifle, Pablo Marin-Palomo, M Deseada Gutierrez Pascual, Stefan Wolf, Frank Smyth, Wolfgang Freude, Christian Koos
Steadily increasing data rates of optical interfaces require spectrally efficient coherent transmission using higher-order modulation formats in combination with scalable wavelength-division multiplexing (WDM) schemes. At the transmitter, optical frequency combs (OFC) lend themselves to particularly precise multi-wavelength sources for WDM transmission. In this work we demonstrate that these advantages can also be leveraged at the receiver by using an OFC as a highly scalable multi-wavelength local oscillator (LO) for coherent detection...
October 31, 2016: Optics Express
https://www.readbyqxmd.com/read/27793395/assessment-of-progressive-pathophysiology-after-early-prenatal-diagnosis-of-the-ebstein-anomaly-or-tricuspid-valve-dysplasia
#14
Elif Seda Selamet Tierney, Doff B McElhinney, Lindsay R Freud, Wayne Tworetzky, Bettina F Cuneo, Maria C Escobar-Diaz, Catherine Ikemba, Brian T Kalish, Rukmini Komarlu, Stéphanie M Levasseur, Michael D Puchalski, Gary M Satou, Norman H Silverman, Anita J Moon-Grady
In fetuses with Ebstein anomaly or tricuspid valve dysplasia (EA/TVD), poor hemodynamic status is associated with worse neonatal outcome. It is not known whether EA/TVD fetuses with more favorable physiology earlier in gestation progress to more severe disease in the third trimester. We evaluated if echocardiographic indexes in EA/TVD fetuses presenting <24 weeks of gestation are reliable indicators of physiologic status later in pregnancy. This multicenter, retrospective study included 51 fetuses presenting at <24 weeks of gestation with EA/TVD and serial fetal echocardiograms ≥4 weeks apart...
September 29, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27790160/the-neuropsychoanalytic-approach-using-neuroscience-as-the-basic-science-of-psychoanalysis
#15
Brian Johnson, Daniela Flores Mosri
Neuroscience was the basic science behind Freud's psychoanalytic theory and technique. He worked as a neurologist for 20 years before being aware that a new approach to understand complex diseases, namely the hysterias, was needed. Solms coined the term neuropsychoanalysis to affirm that neuroscience still belongs in psychoanalysis. The neuropsychoanalytic field has continued Freud's original ideas as stated in 1895. Developments in psychoanalysis that have been created or revised by the neuropsychoanalysis movement include pain/relatedness/opioids, drive, structural model, dreams, cathexis, and dynamic unconscious...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27789396/derivation-of-induced-pluripotent-stem-cells-from-a-familial-alzheimer-s-disease-patient-carrying-the-l282f-mutation-in-presenilin-1
#16
Anna Poon, Tong Li, Carlota Pires, Troels T Nielsen, Jørgen E Nielsen, Bjørn Holst, Andras Dinnyes, Poul Hyttel, Kristine K Freude
Mutations in presenilin 1 (PSEN1) lead to the most aggressive form of familial Alzheimer's disease (AD). Human induced pluripotent stem cells (hiPSCs) derived from AD patients can be differentiated and used for disease modeling. Here, we derived hiPSC from skin fibroblasts obtained from an AD patient carrying a L282F mutation in PSEN1. We transfected skin fibroblasts with episomal iPSC reprogramming vectors targeting human OCT4, SOX2, L-MYC, KLF4, NANOG, LIN28, and short hairpin RNA against TP53. Our hiPSC line, L282F-hiPSC, displayed typical stem cell characteristics with consistent expression of pluripotency genes and the ability to differentiation into the three germ layers...
September 28, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27789395/generation-of-a-gene-corrected-isogenic-control-hipsc-line-derived-from-a-familial-alzheimer-s-disease-patient-carrying-a-l150p-mutation-in-presenilin-1
#17
Anna Poon, Benjamin Schmid, Carlota Pires, Troels T Nielsen, Lena E Hjermind, Jørgen E Nielsen, Bjørn Holst, Poul Hyttel, Kristine K Freude
Mutations in the presenilin 1 (PSEN1) gene lead to the most aggressive form of familial Alzheimer's disease (AD). Human induced pluripotent stem cells (hiPSCs) derived from AD patients and subsequently differentiated can be used for disease modeling. We have previously generated a hiPSC line from a familial AD patient carrying a L150P point mutation in PSEN1. Here we used CRISPR/Cas9 gene editing to correct for the single base pair mutation. This gene-corrected line, L150P-GC-hiPSC, serves as an isogenic control to the mutant line for future investigation of mechanisms and cellular phenotypes altered by this specific PSEN1 mutation...
September 24, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27784195/mitochondrial-spare-respiratory-capacity-is-negatively-correlated-with-nuclear-reprogramming-efficiency
#18
Yan Zhou, Rasha Abdelkadhem Al-Saaidi, Paula Fernandez-Guerra, Kristine K Freude, Rikke Katrine Jentoft Olsen, Uffe Birk Jensen, Niels Gregersen, Poul Hyttel, Lars Bolund, Lars Aagaard, Peter Bross, Yonglun Luo
Nuclear reprogramming efficiency has been shown to be highly variable among different types of somatic cells and different individuals, yet the underlying mechanism remains largely unknown. Several studies have shown that reprogramming of fibroblasts into induced pluripotent stem cells (iPSCs) requires remodeling of mitochondria and a metabolic shift from an oxidative state to a more glycolytic state. In this study, we evaluated the nuclear reprogramming efficiency in relation to mitochondrial bioenergetic parameters of fibroblasts from seven different human individuals...
November 28, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27778143/extranodal-nk-t-cell-lymphoma-nasal-type-enktl-nt-an-update-on-epidemiology-clinical-presentation-and-natural-history-in-north-american-and-european-cases
#19
Bradley M Haverkos, Zenggang Pan, Alejandro A Gru, Aharon G Freud, Rachel Rabinovitch, Meng Xu-Welliver, Brad Otto, Carlos Barrionuevo, Robert A Baiocchi, Rosemary Rochford, Pierluigi Porcu
PURPOSE OF REVIEW: Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT) is an aggressive extranodal non-Hodgkin lymphoma most commonly occurring in East Asia and Latin America but with increasing incidence in the United States. Data on epidemiology, disease presentation, and outcome for European and North American ("Western") cases are very limited. We review published landmark clinical studies on ENKTL-NT in the West and report in detail recent data, including our institutional experience...
October 24, 2016: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/27775550/microrna-29b-mediates-altered-innate-immune-development-in-acute-leukemia
#20
Bethany L Mundy-Bosse, Steven D Scoville, Li Chen, Kathleen McConnell, Hsiaoyin C Mao, Elshafa H Ahmed, Nicholas Zorko, Sophia Harvey, Jordan Cole, Xiaoli Zhang, Stefan Costinean, Carlo M Croce, Karilyn Larkin, John C Byrd, Sumithira Vasu, William Blum, Jianhua Yu, Aharon G Freud, Michael A Caligiuri
Natural killer (NK) cells can have potent antileukemic activity following haplo-mismatched, T cell-depleted stem cell transplantations for the treatment of acute myeloid leukemia (AML), but they are not successful in eradicating de novo AML. Here, we have used a mouse model of de novo AML to elucidate the mechanisms by which AML evades NK cell surveillance. NK cells in leukemic mice displayed a marked reduction in the cytolytic granules perforin and granzyme B. Further, as AML progressed, we noted the selective loss of an immature subset of NK cells in leukemic mice and in AML patients...
December 1, 2016: Journal of Clinical Investigation
keyword
keyword
28772
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"