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Myeloproliferative neoplasma

Darko Antic, Ivo Elezovic, Natasa Milic, Nada Suvajdzic, Ana Vidovic, Maja Perunicic, Irena Djunic, Mirjana Mitrovic, Dragica Tomin
Isolated myeloid sarcoma is an extramedullary tumor of immature myeloid cells defined by the absence of leukemia history, myelodisplastic syndrome, or myeloproliferative neoplasma with a negative bone marrow biopsy. Myeloid sarcoma is a very rare condition, and few cases have been reported. We reviewed data of 12 patients with isolated myeloid sarcoma managed at a single center to determine the possible prognostic factors affecting patient survival, such as age, sex, type, localization, and treatment options...
February 2013: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Kotaro Hishiki, Mai Toyama, Ryo Sato, Izumi Suzuki, Reiko Kisugi, Masaru Koike, Kaichi Nishiwaki, Hidekazu Masuoka, Hiroshi Yoshida
The pseudohyperkalemia in thrombocytosis is assumed to be due to potassium released from blood cells during blood clotting as reported previously, but its mechanisms remain to be cleared. Although plasma potassium measurements with blood collection tubes containing heparin are performed in many hospitals to avoid pseudohyperkalemia, the burden on patients may come out with further blood sampling by another heparinized tube. Taken together, we investigated laboratory data possibly involved in pseudohyperkalemia in 184 samples from patients with myeloproliferative neoplasma (MPN), and studied estimation capability for true values of serum potassium, driving a correction formula by means of several laboratory data to explain the difference of measured potassium values (K-difference: serum value minus plasma value)...
June 2012: Rinsho Byori. the Japanese Journal of Clinical Pathology
Yan-Ling Ren, Hong-Yan Tong
This study was aimed to explore the effect of homoharringtonine in combination with AG490 on JAK2-STAT5 associated signal pathway in HEL cells, and analyze its mechanism so as to provide theoretical basis for therapy of chronic myeloproliferative neoplasma by new program. The cell survival rates were tested by MTT, apoptosis was tested by flow cytometry after HEL cells were treated by 20 ng/ml HHT, 100 µmol/L AG490 and 20 ng/ml HHT in combination with 100 µmol/L AG490, while the signal proteins such as P-JAK2, P-STAT5 and BCL-xL activated by abnormal activated JAK2 were tested by Western blot...
October 2011: Zhongguo Shi Yan Xue Ye Xue za Zhi
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