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dengue and hypokalemia

Ajai Kumar Singh, Pradeep Kumar Maurya, Dinkar Kulshreshtha, Mayur Deepak Thakkar, Anup Kumar Thacker
OBJECTIVE: Acute neuromuscular weakness related to hypokalemia is a readily treatable disorder associated with diverse aetiologies. In this study we aim to report clinical pattern and biochemical features to identify the different aetiologies of the hypokalemic neuromuscular weakness. METHODS: Retrospective reviews of the medical record were analysed. Evaluation included demography, clinical features, investigations performed to ascertain the aetiologies. All the patients were categorised in to 3 groups; Idiopathic hypokalemic paralysis (IHP), dengue associated hypokalemic paralysis (DHP) and secondary group (SG) which included renal tubular acidosis (RTA- 1 and 2), thyrotoxic periodic paralysis (TPP) and Gitelman's syndrome (GS)...
September 15, 2017: Acta Neurologica Taiwanica
Viroj Wiwanitkit
No abstract text is available yet for this article.
December 2017: Journal of Clinical Neuromuscular Disease
Rajesh Verma, Vikram V Holla, Vijay Kumar, Amita Jain, Nuzhat Husain, Kiran Preet Malhotra, Ravindra Kumar Garg, Hardeep Singh Malhotra, Praveen Kumar Sharma, Neeraj Kumar
BACKGROUND: Acute myopathy is a common cause of acute motor quadriparesis which has various etiologies with different courses of illness and prognosis depending on the cause. Understanding this diversity helps us in proper approach toward diagnosis, predicting the prognosis, and possible complications and in improving the treatments that are being provided. This study was planned to study the clinical, electrophysiological, and etiological profile of patients presenting with acute myopathy...
January 2017: Annals of Indian Academy of Neurology
Pradeep K Maurya, Dinkar Kulshreshtha, Ajai K Singh, Anup K Thacker
OBJECTIVES: Dengue is a mosquito-borne disease caused by arbovirus and well known for its typical fever with thrombocytopenia syndrome. Acute hypokalemic quadriparesis is a rare presentation of dengue with uncertain pathogenesis. We aim to describe the clinical and biochemical characteristics of rapidly resolving weakness related to hypokalemia in patients infected with dengue virus. METHODS: A retrospective review of the records of patients with diagnosis of dengue-associated hypokalemic weakness was performed...
December 2016: Journal of Clinical Neuromuscular Disease
Abeer Goel, Basvaraju Mm
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Limei Tan, Junping Wang, Fansen Zeng, Yong Zhang, Chunxiao Fang, Chuan Nie, Yi Xu, Jie Yang
OBJECTIVE: To explore the clinical manifestations and laboratory examination characteristics of neonatal dengue fever. METHOD: A retrospective analysis of 12 cases of neonatal dengue fever treated in the Guangdong Women and Children's Hospital and Guangzhou Women and Children's Medical Center was conducted, and related literature was reviewed. RESULT: Twelve cases of neonatal dengue fever included 9 males and 3 females; their age was 30 min after birth to 29 d, the age of onset was 30 min-24 d...
December 2015: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Rajendra Singh Jain, Pankaj Kumar Gupta, Rakesh Agrawal, Sunil Kumar, Kapil Khandelwal
Neurological manifestations are unusual in dengue fever and can be due to neurotropic effect, systemic complications of dengue infection, or immune mediated. Acute hypokalemic paralysis is a rare systemic complication of dengue infection; however, hypokalemia along with hypomagnesemia has not been reported earlier. We herein report an extremely unusual and probably the first case of dengue infection in a 30-year-old male who presented to us with hypokalemic paralysis along with hypomagnesemia. This case report highlights that hypomagnesemia may be a significant complication in dengue infection...
August 2015: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Hardeep Singh Malhotra, Ravindra Kumar Garg
Dengue-associated hypokalemic paralysis is considered an important but under-emphasized neuromuscular complication of dengue virus infection. Review of the published literature reveals that 35 instances of hypokalemic paralysis associated with dengue have been recorded from the Indian subcontinent and all but two, were males. The median age of presentation is 29 years and moderate to severe grade pure motor quadriparesis is precipitated during the phase of defervescence of moderate to high-grade fever. Recovery starts within 12h of potassium supplementation and is usually complete in a couple of days...
May 15, 2014: Journal of the Neurological Sciences
Ravindra Kumar Garg, Hardeep Sing Malhotra, Rajesh Verma, Pawan Sharma, Maneesh Kumar Singh
BACKGROUND: Hypokalemic paralysis is characterized by episodes of acute muscle weakness associated with hypokalemia. In this study, we evaluated the possible etiological factors in patients of hypokalemic paralysis. MATERIALS AND METHODS: We reviewed the records of 29 patients who were admitted with a diagnosis of hypokalemic paralysis. Modified Guillain-BarreĀ“ Syndrome disability scale was used to grade the disability. RESULTS: In this study, 15 (51...
July 2013: Annals of Indian Academy of Neurology
Ashok K Kayal, Munindra Goswami, Marami Das, Rahul Jain
BACKGROUND: Acute hypokalemic paralysis, characterized by acute flaccid paralysis is primarily a calcium channelopathy, but secondary causes like renal tubular acidosis (RTA), thyrotoxic periodic paralysis (TPP), primary hyperaldosteronism, Gitelman's syndrome are also frequent. OBJECTIVE: To study the etiology, varied presentations, and outcome after therapy of patients with hypokalemic paralysis. MATERIALS AND METHODS: All patients who presented with acute flaccid paralysis with hypokalemia from October 2009 to September 2011 were included in the study...
April 2013: Annals of Indian Academy of Neurology
Durgesh Kumar Gupta, A K Vaish, Rajesh Kumar Arya, Shyam Chand Chaudhary
Dengue is the most common and widespread arthropod borne arboviral infection in the world today. Recent observations indicate that the clinical profile of dengue fever is changing with neurological manifestations being reported more frequently. A patient with dengue fever presented to us with symptoms suggestive of acute flaccid paralysis, and on subsequent investigation he was diagnosed as a case of hypokalaemic quadriparesis. Clinicians in the endemic area should be aware of such association of acute pure motor reversible quadriparesis with dengue fever...
2011: BMJ Case Reports
Manish Gutch, Avinash Agarwal, Amrendra Amar
Dengue is the most important mosquito-borne, arboviral infection found in tropical and sub-tropical climates. Clinical presentation varies from a severe flu-like illness to a potentially lethal dengue hemorrhagic fever. Dengue has been regarded as a nonneurotropic virus. However, there are reports describing neurological involvements in dengue virus infection. The neurological involvement in dengue virus infection includes encephalitis, acute disseminated encephalomyelitis, transverse myelitis, and Guillain-Barre syndrome...
January 2012: Journal of Natural Science, Biology, and Medicine
Amitava Roy, Anil Kumar Tripathi, Shailendra Prasad Verma, Himanshu Reddy, Nirdesh Jain
The authors report acute hypokalaemic quadriparesis in two young patients that occurred during dengue epidemic in 2010 in India. Both patients developed flexic type of pure motor weakness in all four limbs without bladder bowel involvement, following 2 to 3 days of fever and malaise. Higher mental functions were normal. Serum potassium level was very low; 2-2.5 m mol/l. Non-structural protein (NS(1))-antigen and immunoglobulin M-antibody for dengue were positive in both patients. Both patients improved with potassium supplementation...
2011: BMJ Case Reports
Harmanjit Singh Hira, Amandeep Kaur, Anuj Shukla
BACKGROUND: Dengue infections may present with neurological complications. Whether these are due to neuromuscular disease or electrolyte imbalance is unclear. MATERIALS AND METHODS: Eighty-eight patients of dengue fever required hospitalization during epidemic in year 2010. Twelve of them presented with acute neuromuscular weakness. We enrolled them for study. Diagnosis of dengue infection based on clinical profile of patients, positive serum IgM ELISA, NS1 antigen, and sero-typing...
January 2012: Journal of Neurosciences in Rural Practice
Sanjeev Jha, M K Ansari
Dengue infection is endemic to India and an important public health problem. We report three confirmed cases of dengue infection with acute, pure motor, reversible quadriparesis due to hypokalemia. Clinicians should be aware of such an association and consider the clinical possibility in the differential diagnosis while evaluating acute quadriparesis in patients with dengue fever, especially in endemic areas.
July 2010: Neurology India
Adisorn Lumpaopong, Pinyada Kaewplang, Veerachai Watanaveeradej, Prapaipim Thirakhupt, Sangkae Chamnanvanakij, Konggrapun Srisuwan, Natthida Pongwilairat, Yupapin Chulamokha
Serum electrolytes and urine analysis results were retrospectively reviewed in children with either dengue fever (DF) or dengue hemorrhagic fever (DHF). Children who had positive serology for dengue infection and serum electrolytes determined before starting intravenous fluid were included in the study. During the years 2004-2007, 73 DF patients, age 9.29 +/- 3.62 years, and 77 DHF patients, age 10.04 +/- 3.64 years were enrolled in the study. The patients were admitted to the hospital on average on days 4...
January 2010: Southeast Asian Journal of Tropical Medicine and Public Health
Siripen Kalayanarooj
BACKGROUND: DHF is characterized by plasma leakage and abnormal hemostasis. About 20% of DHF patients do require colloidal solution in addition to conventional crystalloid solution for the treatment. There is only one colloidal solution, 10% Dextran-40 in NSS that proved to be effective for this group of DHF patients. OBJECTIVE: To compare 10% dextran-40 in NSS with 10% Haes-steril in NSS in the management of DHF cases with severe plasma leakage for their effectiveness and impact on renal function, hemostasis, disease severity, and complications...
October 2008: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Ruo-su Ying, Xiao-ping Tang, Fu-chun Zhang, Wei-ping Cai, Yan-qing Chen, Jian Wang, Wen-xin Hong, Ying-zi Long
OBJECTIVE: To study the clinical characteristics of the patients with dengue fever (DF) seen from 2002 to 2006 in Guangzhou in order to prevent and treat dengue fever better. METHODS: Clinical data from 1342 inpatients with DF seen from 2002 to 2006 were retrospectively analyzed. The dengue virus was isolated by C6/36 cell culture and genotyped by reverse transcriptase-polymerase chain reaction and gene sequence analysis. RESULTS: The average age of the patients was 34...
June 2007: Chinese Journal of Experimental and Clinical Virology
Djoko Widodo, Budi Setiawan, Khie Chen, Leonard Nainggolan, Widayat Djoko Santoso
AIM: to know the prevalence of hypokalemia that occurs in hospitalized patients with infectious diseases. METHODS: a cross sectional study was carried out in the internal ward Cipto Mangunkusumo General Hospital in Jakarta from December 2005 until June 2006. All hospitalized patients with infectious diseases receiving "replacement solution" were included in this study. We collected the blood sample to perform the serum potassium level at the time of admission and discharge...
October 2006: Acta Medica Indonesiana
A Khongphatthallayothin, P Chotivitayatarakorn, S Somchit, A Mitprasart, S Sakolsattayadorn, C Thisyakorn
Two patients with serologically-proven dengue virus infection and Morbitz type I second degree atrioventricular (AV) block are described. A 7 years old boy (patient 1) with grade 2 and a 7 years old girl (patient 2) with grade 3 illness were admitted to the hospital on the 3rd and the 5th day of the illness, respectively. Both had typical resentation for dengue hemorrhagic fever including fever, hepatomegaly, thrombocytopenia and signs of extravascular leakage. The 7 year old girl also had epistaxis and anemia (Hct 24%)...
December 2000: Southeast Asian Journal of Tropical Medicine and Public Health
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