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https://www.readbyqxmd.com/read/29684500/the-clinicopathological-comparison-among-nodal-cases-of-idiopathic-multicentric-castleman-disease-with-and-without-tafro-syndrome
#1
Nozomu Kurose, Chizuru Futatsuya, Ken-Ichi Mizutani, Motona Kumagai, Akihiro Shioya, Xin Guo, Akane Aikawa, Satoko Nakada, Shino Fujimoto, Hiroshi Kawabata, Yasufumi Masaki, Kazue Takai, Sadao Aoki, Masaru Kojima, Shigeo Nakamura, Sohsuke Yamada
Multicentric Castleman disease (MCD) is a systemic inflammatory disease potentially caused by an increase in the serum interleukin-6 (IL-6) level. Idiopathic MCD (iMCD) is histopathologically classified into three types: plasmacytic (PC), mixed, and hypervascular (hyperV) types. Recently, a unique clinical phenotype with a poor prognosis overlap with iMCD, thrombocytopenia, anasarca, fever, renal failure or reticulin fibrosis, and organomegaly (TAFRO syndrome), has been reported from Japan, but its detailed clinicopathological features remain unclear...
April 20, 2018: Human Pathology
https://www.readbyqxmd.com/read/29670135/clinical-characteristics-and-risk-factors-for-overlapping-rheumatoid-arthritis-and-sj%C3%A3-gren-s-syndrome
#2
Huaxia Yang, Sainan Bian, Hua Chen, Li Wang, Lidan Zhao, Xuan Zhang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang
This study investigated the clinical characteristics and risk factors for overlapping rheumatoid arthritis and Sjögren's syndrome (RA/SS). Patients with RA/SS in Peking Union Medical College Hospital from January 2012 to January 2017 were retrospectively analysed and compared to those of sex- and age-matched RA or SS controls. Logistic regression analysis was used to identify risk factors. Altogether, 105 consecutive patients with RA/SS were enrolled. Ninety-seven (92.4%) of them were female, with a mean age of 51...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669948/survey-of-tick-borne-zoonotic-viruses-in-wild-deer-in-hokkaido-japan
#3
Leo Uchida, Daisuke Hayasaka, Mya Myat Ngwe Tun, Kouichi Morita, Yasukazu Muramatsu, Katsuro Hagiwara
Tick-borne encephalitis (TBE) and severe fever with thrombocytopenia syndrome (SFTS) are both tick-borne zoonotic diseases caused by TBE virus (TBEV) and SFTS phlebovirus (SFTSV). In 2016, a second domestic TBE case was reported in Hokkaido, Japan, after an absence of 23 years. We conducted IgG ELISA for TBEV and SFTSV on 314 deer (Cervus nippon yesoensis) serum samples collected from 3 places in Hokkaido. There were 7 seropositive samples for TBEV but none for SFTSV by ELISA. The specificity of the 7 positive samples was confirmed by neutralization tests against TBEV, and 5 sera showed 320 to 640 of 50% focus reduction endpoint titers...
April 19, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29668136/-a-fatal-case-series-of-rocky-mountain-spotted-fever-in-sonora-m%C3%A3-xico
#4
Jesús Delgado-De la Mora, Jesús David Licona-Enríquez, Marcia Leyva-Gastélum, David Delgado-De la Mora, Adela Rascón-Alcantar, Gerardo Álvarez-Hernández
INTRODUCTION: Rocky Mountain spotted fever is a highly lethal infectious disease, particularly if specific treatment with doxycycline is given belatedly. OBJECTIVE: To describe the clinical profile of fatal Rocky Mountain spotted fever cases in hospitalized patients in the state of Sonora, México. MATERIALS AND METHODS: We conducted a cross-sectional study on a series of 47 deaths caused by Rickettsia rickettsii from 2013 to 2016. The diagnosis of Rocky Mountain spotted fever was confirmed in a single blood sample by polymerase chain reaction (PCR) or by a four-fold increase in immunoglobulin G measured in paired samples analyzed by indirect immunofluorescence...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29665796/case-report-detection-of-the-identical-virus-in-a-patient-presenting-with-severe-fever-with-thrombocytopenia-syndrome-encephalopathy-and-the-tick-that-bit-her
#5
Uh Jin Kim, Dong-Min Kim, Seong Eun Kim, Seung Ji Kang, Hee-Chang Jang, Kyung-Hwa Park, Sook In Jung
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease. Haemophysalis longicornis ticks have been considered the vector of severe fever with thrombocytopenia syndrome virus (SFTSV). However, clear data on the transmission of SFTS from ticks to humans are limited. CASE PRESENTATION: We report an 84-year-old woman who presented with fever and altered mentality, which was confirmed as SFTS with encephalopathy by reverse-transcription polymerase chain reaction in blood and cerebrospinal fluid...
April 17, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29664718/transmission-of-severe-fever-with-thrombocytopenia-syndrome-virus-by-haemaphysalis-longicornis-ticks-china
#6
Lu Zhuang, Yi Sun, Xiao-Ming Cui, Fang Tang, Jian-Gong Hu, Li-Yuan Wang, Ning Cui, Zhen-Dong Yang, Dou-Dou Huang, Xiao-Ai Zhang, Wei Liu, Wu-Chun Cao
We demonstrate maintenance and transmission of severe fever with thrombocytopenia syndrome virus by Haemaphysalis longicornis ticks in the larva, nymph, and adult stages with dissemination in salivary gland, midgut, and ovarian tissues. The H. longicornis tick is a competent vector to transmit this virus in both transovarial and transstadial modes.
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29664384/seroprevalence-of-severe-fever-with-thrombocytopenia-syndrome-virus-antibodies-in-rural-areas-south-korea
#7
Mi Ah Han, Choon-Mee Kim, Dong-Min Kim, Na Ra Yun, Sun-Whan Park, Myung Guk Han, Won-Ja Lee
We investigated 1,228 residents of 3 rural areas in South Korea and determined that 50 (4.1%) were positive for severe fever with thrombocytopenia syndrome virus antibodies. Fever and gastrointestinal symptoms in the previous 3 years and career duration were associated with virus seropositivity.
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29657007/update-on-flea-and-tick-associated-diseases-of-cats
#8
Michael R Lappin
There are multiple vector-borne diseases in cats, the most prominent being those transmitted by mosquitos, sand flies, fleas, and ticks. Many of the agents vectored by fleas or ticks have been grown or amplified from blood or have induced antibodies in the serum of normal cats or those with clinical signs like fever and will be the focus of this manuscript. As high as 80% of fleas collected from cats contain at least one organism that could induce illness in cats or people. Anaplasma phagocytophilum, Bartonella spp...
April 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29650038/a-lifelong-study-of-a-pack-rhodesian-ridgeback-dogs-reveals-subclinical-and-clinical-tick-borne-anaplasma-phagocytophilum-infections-with-possible-reinfection-or-persistence
#9
Emil Hovius, Arnout de Bruin, Leo Schouls, Joppe Hovius, Niels Dekker, Hein Sprong
BACKGROUND: Various tick-borne infections often occur without specific clinical signs and are therefore notoriously hard to diagnose separately in veterinary practice. Longitudinal studies over multiple tick seasons performing clinical, serological and molecular investigations in parallel, may elucidate the relationship between infection and disease. In this regard, six related Rhodesian Ridgeback dogs living as a pack became subject of lifetime studies due to ongoing tick infestations and recurring clinical problems...
April 12, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29643242/rlrs-and-tlrs-signaling-pathways-cause-aberrant-production-of-inflammatory-cytokines-chemokines-in-an-sftsv-infection-mouse-model
#10
Shintaro Yamada, Masayuki Shimojima, Ryo Narita, Yuta Tsukamoto, Hiroki Kato, Masayuki Saijo, Takashi Fujita
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a tick-borne phlebovirus of the family Bunyaviridae , the SFTS virus (SFTSV). Wild type and type I interferon (IFN-I) receptor 1-deficient (IFNAR1-/- ) mice have been established as non-lethal and lethal models of SFTSV infection, respectively. However, the mechanisms of IFN-I production in vivo and the factors causing the lethal disease are not well understood. Using bone marrow chimeric mice, we found that IFN-I signaling in hematopoietic cells was essential for survival from lethal SFTSV infection...
April 11, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29628386/caffeic-acid-a-coffee-related-organic-acid-inhibits-infection-by-severe-fever-with-thrombocytopenia-syndrome-virus-in-vitro
#11
Motohiko Ogawa, Yoshitaka Shirasago, Shuji Ando, Masayuki Shimojima, Masayuki Saijo, Masayoshi Fukasawa
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) causes tick-borne hemorrhagic fever in East Asia. The disease is characterized by high morbidity and mortality. Here, we evaluated the effects of caffeic acid (CA), a coffee-related organic acid with antiviral effects, against SFTSV infection. CA dose-dependently inhibited SFTSV infection in permissive human hepatoma Huh7.5.1-8 cells when SFTSV was added into the culture medium with CA. However, quinic acid (QA), another coffee-related organic acid, did not inhibit SFTSV infection...
April 5, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29626596/renal-histology-in-a-patient-with-tafro-syndrome-a-case-report
#12
Hiroki Mizuno, Akinari Sekine, Masahiko Oguro, Yoichi Oshima, Masahiro Kawada, Keiichi Sumida, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Rikako Hiramatsu, Eiko Hasegawa, Junichi Hoshino, Naoki Sawa, Takashi Fujii, Kenmei Takaichi, Kenichi Ohashi, Yoshifumi Ubara
An 84-year-old Japanese man was admitted due to anasarca, thrombocytopenia, systemic inflammation, and progressive renal insufficiency, resistant to diuretics, glucocorticoid therapy and plasma exchange. Renal biopsy showed diffuse endocapillary proliferation and mesangiolysis without any immune deposits. Tocilizumab suppressed systemic inflammation, resulting in improvement of anasarca and renal dysfunction, but thrombocytopenia persisted and platelet-associated IgG antibody was elevated. Though romiplostim was effective for thrombocytopenia, the patient died of aspiration pneumonia after cerebral hemorrhage...
April 4, 2018: Human Pathology
https://www.readbyqxmd.com/read/29615316/-18-f-fdg-pet-and-histopathologic-findings-in-a-patient-with-severe-fever-with-thrombocytopenia-syndrome
#13
Chang Kyung Kang, Su Jin Choi, Jiwon Koh, Yoon Kyung Jeon, Ki Hyun Kim, Junho Chung, Pyoeng Gyun Choe, Nam-Joong Kim, Wan Beom Park, Myoung-Don Oh
We report on a patient with severe fever with thrombocytopenia syndrome who fully recovered. Imaging with 2-deoxy-2-fluoro-glucose positron emission tomography showed hypermetabolism in regional lymph nodes and the spleen. Histopathological findings of affected lymph nodes showed subacute necrotizing lymphadenitis and the presence of virus-infected cells.
March 28, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29606619/spatiotemporal-patterns-of-severe-fever-with-thrombocytopenia-syndrome-in-china-2011-2016
#14
Jimin Sun, Liang Lu, Haixia Wu, Jun Yang, Keke Liu, Qiyong Liu
Severe fever with thrombocytopenia syndrome (SFTS) is emerging and the number of SFTS cases have increased year by year in China. However, spatiotemporal patterns and trends of SFTS are less clear up to date. In order to explore spatiotemporal patterns and predict SFTS incidences, we analyzed temporal trends of SFTS using autoregressive integrated moving average (ARIMA) model, spatial patterns, and spatiotemporal clusters of SFTS cases at the county level based on SFTS data in China during 2011-2016. We determined the optimal time series model was ARIMA (2, 0, 1) × (0, 0, 1)12 which fitted the SFTS cases reasonably well during the training process and forecast process...
March 27, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29604992/first-description-of-the-pathogenicity-of-babesia-vogeli-in-experimentally-infected-dogs
#15
Jiawei Wang, Jilei Zhang, Patrick Kelly, Xiaofeng Zheng, Min Li, Jinfeng You, Ke Huang, Haixiang Qiu, Yaoyao Wang, Rong Zhang, Jianji Li, Junsheng Dong, Yi Feng, Jinlin Zhou, Chengming Wang
Babesiosis is a tick-borne disease that occurs worldwide with the most recognized Babesia species that infect dogs being Babesia canis, B. vogeli, B. rossi and B. gibsoni. While B. vogeli is reported in dogs worldwide, clinical and laboratory data on infections is based on reports of naturally infected dogs. To provide reliable data on the clinical and laboratory abnormalities associated with acute and more chronic infections in healthy dogs free of other tick-borne diseases, we experimentally infected dogs with a Chinese strain of B...
April 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29598953/chemoradiotherapy-using-retrograde-superselective-intra-arterial-infusion-for-tongue-cancer-analysis-of-therapeutic-results-in-118-cases
#16
Kenji Mitsudo, Yuichiro Hayashi, Shuhei Minamiyama, Nobuhide Ohashi, Masaki Iida, Toshinori Iwai, Senri Oguri, Toshiyuki Koizumi, Mitomu Kioi, Makoto Hirota, Izumi Koike, Masaharu Hata, Iwai Tohnai
OBJECTIVES: To evaluate the therapeutic results and rate of organ preservation in patients with squamous cell carcinoma of the tongue treated with retrograde superselective intra-arterial chemoradiotherapy. MATERIALS AND METHODS: Between June 2006 and June 2015, 118 patients with tongue cancer were treated with intra-arterial chemoradiotherapy. Treatment consisted of radiotherapy (total 50-70 Gy) and daily concurrent intra-arterial chemotherapy (docetaxel, total 50-70 mg/m2 ; cisplatin, total 125-175 mg/m2 ) for 5-7 weeks...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29588492/sfts-phlebovirus-promotes-lc3-ii-accumulation-and-nonstructural-protein-of-sfts-phlebovirus-co-localizes-with-autophagy-proteins
#17
Yue Sun, Miao-Miao Liu, Xiao-Ying Lei, Xue-Jie Yu
Autophagy is essential for eukaryotic cell homeostasis and can perform both anti-viral and pro-viral roles depending on the kinds of viruses, cell types and cell environment. Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) is a newly discovered tick-borne virus in the Phenuiviridae family that causes a severe hemorrhagic fever disease in East Asia. In this study we determined interactions between SFTSV and autophagy. Our results showed that LC3-II (microtubule associated protein 1 light chain 3-II) protein accumulated from 4 h to 24 h after SFTSV infection compared to mock-infected Vero cells, and the use of E64d and pepstatin A did not affect the expression of LC3-II protein, which indicated that the increased LC3-II may be the result of inhibition of autophagic degradation caused by SFTSV infection...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29587642/guillain-barre-syndrome-associated-with-hemorrhagic-fever-with-renal-syndrome-in-china-a-case-report
#18
Jie Jiao, Lei Wu, Jianyuan Yin, Xiaojiao Quan, Wei Chen, Jie Hu
BACKGROUND: We describe a case of Guillain-Barre syndrome (GBS) associated with hemorrhagic fever with renal syndrome. To our knowledge, only five cases of GBS associated with Hantavirus infection have been reported so far. CASE PRESENTATIONS: A 62-year-old man presented intermittent fever, chill and oliguria. According to remarkable leukocytosis, atypical lymphocytes, thrombocytopenia and former dwelling in hemorrhagic fever-endemic area, he was suspected as hemorrhagic fever with renal syndromeand certified with positive Hantavirus IgG...
March 27, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29578925/successful-management-of-a-rare-cause-of-hemolytic-uremic-syndrome-with-eculizumab-in-a-child
#19
Caner Alparslan, Önder Yavaşcan, Belde Kasap Demir, Bahriye Atmiş, Aysun Karabay Bayazit, Göksel Leblebisatan, Elif P Öncel, Demet Alaygut, Fatma Mutlubaş, Nejat Aksu
BACKGROUND: Hemolytic uremic syndrome (HUS) is characterized by microangiopathic hemolytic anemia, acute renal failure, and thrombocytopenia. It very rarely coexists with acute lymphoblastic leukemia (ALL) emerging before, simultaneously, or after the diagnosis has been made, and management of the patient may be difficult. CASE: We present the case of a 7-year-old boy who was diagnosed with HUS and initially managed by hemodialysis (HD). Thereafter, HUS progressed, and neurological findings developed...
March 23, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29564278/thrombocytopenia-in-hiv-patients-coinfected-with-tuberculosis
#20
A S Sandhya, Brijesh Prajapat
Thrombocytopenia is one of the most common hematological manifestations seen in HIV patients with approximately 40% of the patients developing thrombocytopenia during their course of illness. Opportunistic infection like tuberculosis is a rare but curative cause of thrombocytopenia in these patients. Clinically, it is a challenge to determine the exact cause and decide the treatment of thrombocytopenia in these patients as both infections can lead to significant thrombocytopenia by varied mechanisms. The treatment options are limited by drug antitubercular treatment highly active antiretroviral therapy (ATT and HAART)-induced thrombocytopenia...
October 2017: Journal of Family Medicine and Primary Care
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