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fever with thrombocytopenia

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https://www.readbyqxmd.com/read/28107859/dengue-fever-may-mislead-the-surgeons-when-it-presents-as-an-acute-abdomen
#1
Bingumal Jayasundara, Lalith Perera, Ajith de Silva
OBJECTIVE: To review the management experience of a consecutive series of patients presenting as acute surgical abdomen whom were ultimately diagnosed to have DF (Dengue fever)/DHF (Dengue hemorrhagic fever). METHODS: Clinical data of all cases of apparent acute abdomen (AA) which were later confirmed as having DF/DHF reviewed by two surgical units from December 2012 to December 2013 were analyzed. Initially confirmed patients with DF/DHF who developed abdominal symptoms were not considered...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28103832/thromboelastometry-analysis-of-thrombocytopenic-dengue-patients-a-cross-sectional-study
#2
Felipe Maia de Toledo Piza, Thiago Domingos Corrêa, Alexandre Rodrigues Marra, João Carlos Campos Guerra, Roseny Dos Reis Rodrigues, Andrea Aparecida Rocco Villarinho, Valdir Fernandes de Aranda, Sandra Christina Pereira Lima Shiramizo, Maria Roza de Jesus de Lima, Esper Georges Kallas, Alexandre Biasi Cavalcanti
BACKGROUND: Dengue virus infection (DVI) is a prevalent and potentially fatal viral disease associated with coagulopathy. So far, the coagulation profile of DVI patients with thrombocytopenia has not been assessed through a viscoelastic test such as rotational thromboelastometry. We aimed to describe the prevalence and characteristics of coagulation abnormalities in dengue fever outpatients with thrombocytopenia, addressed by both rotational thromboelastometry and conventional coagulation tests...
January 19, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28103211/notes-from-the-field-hantavirus-pulmonary-syndrome-in-a-migrant-farm-worker-colorado-2016
#3
Grace Marx, Kaylan Stinson, Monte Deatrich, Bernadette Albanese
HASH(0x3b9a090)
20, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28093540/human-granulocytic-anaplasmosis-as-a-cause-of-febrile-illness-in-korea-since-at-least-2006
#4
Jongyoun Yi, Kye-Hyung Kim, Mee Kyung Ko, Eun Yup Lee, Su Jin Choi, Myoung-Don Oh
Human granulocytic anaplasmosis (HGA) is a tick-borne rickettsial zoonosis with fever, thrombocytopenia, and leukopenia. HGA has been reported in Korea in 2013 but it is uncertain how long it has existed. A retrospective study was conducted on patients who underwent bone marrow examination due to fever and cytopenia, with no clear hematologic or microbiologic causes, from 2003 through 2012. Laboratory diagnosis was made by detecting 16S rRNA genes of Anaplasma phagocytophilum from the stored blood samples. Among the 70 patients, five (7...
January 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28089865/pathogens-and-epidemiologic-features-of-severe-fever-with-thrombocytopenia-syndrome-in-hubei-province-china
#5
Jianbo Zhan, Jing Cheng, Bing Hu, Jing Li, Ruangang Pan, Zhaohui Yang, Wenjing Zou, Faxian Zhan, Deyin Guo
To evaluate the aetiological agents and epidemiologic features of severe fever with thrombocytopenia syndrome (SFTS) in Hubei Province, China, sera from patients were collected from January to December 2011. All cases occurred from April to December, and the epidemic peaked from May to August. The ages of patients ranged from 10 to 86 years (median=55years), and the incidence of SFTS increased with age. The female:male ratio of cases was 1.008:1, and 54.6% (77/141) and 1.4% (2/141) of the cases were confirmed by qPCR to be SFTSV and Hantavirus (HV) infection, respectively...
January 12, 2017: Virus Research
https://www.readbyqxmd.com/read/28088586/a-case-control-study-of-risk-sources-for-severe-fever-with-thrombocytopenia-syndrome-in-hubei-province-china
#6
Xuesen Xing, Xuhua Guan, Li Liu, Junqiang Xu, Guoming Li, Jianbo Zhan, Gongping Liu, Xiaoqing Jiang, Xingfu Shen, Yongzhong Jiang, Yang Wu, Hao Zhang, Jing Huang, Fan Ding, Sha Sha, Man Liu, Faxian Zhan
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease caused by a novel bunyavirus, was discovered in rural areas of Central China in 2009. METHODS: A case-control study based on hospital data was applied to detect the potential risk sources for SFTS in SFTS-endemic counties in Hubei Province. Cases were defined as hospitalized SFTSV confirmed patients. Controls were randomly selected from non-SFTSV patients in the same hospital ward within 2 weeks of inclusion of the cases, and they were matched by age (+/- 5 years) and gender according to 1:2 matching condition...
January 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28086978/correlation-of-cytokine-level-with-the-severity-of-severe-fever-with-thrombocytopenia-syndrome
#7
Miao-Miao Liu, Xiao-Ying Lei, Hao Yu, Jian-Zhi Zhang, Xue-Jie Yu
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) was an emerging hemorrhagic fever that was caused by a tick-borne bunyavirus, SFTSV. Although SFTSV nonstructural protein can inhibit type I interferon (IFN-I) production Ex Vivo and IFN-I played key role in resistance SFTSV infection in animal model, the role of IFN-I in patients is not investigated. METHODS: We have assayed the concentration of IFN-α, a subtype of IFN-I as well as other cytokines in the sera of SFTS patients and the healthy population with CBA (Cytometric bead array) assay...
January 13, 2017: Virology Journal
https://www.readbyqxmd.com/read/28086881/dengue-fever-in-renal-transplant-patients-a-systematic-review-of-literature
#8
Ranga Migara Weerakkody, Jean Ansbel Patrick, Mohammed Hussain Rezvi Sheriff
BACKGROUND: Dengue fever in renal transplanted patients has not been studied well, and we review all the literature about episodes dengue fever in renal transplant patients. METHODS: The aim was to describe clinico-pathological characteristics, immunosuppressive protocols, need renal outcome and mortality. PubMed, LILACS, Google Scholar and Research Gate were searched for "Dengue" and "Renal/Kidney Transplantation" with no date limits. Hits were analyzed by two researchers separately...
January 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28072887/dengue-fever-in-travellers-and-risk-of-local-spreading-case-reports-from-southern-italy-and-literature-update
#9
Claudia Fabrizio, Luciana Lepore, Maria Chironna, Gioacchino Angarano, Annalisa Saracino
Dengue fever (DF), an arbovirosis caused by Dengue viruses (DV, serotypes 1-4), is responsible for an increasing number of travel-related acute febrile illnesses due to population growth, climate changes, spreading by viremic travellers, and improved laboratory diagnosis. The presence of efficient vectors (mosquito Aedes albopictus) has also been described in temperate regions including Italy which is considered the most heavily infected European country. Normally characterized by non-specific signs and symptoms, DF incidence is probably underestimated, especially in non-endemic countries, but the risk of severe forms is substantial...
January 5, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28070489/acute-disseminated-histoplasmosis-with-atypical-lymphocytosis-in-an-immunocompetent-host
#10
Ayman Elbadawi, Hamdy M A Ahmed, Hussain Adly, Mohamed A Elkhouly, Samar Abohamed, Ann R Falsey
65 year-old-male presented with a one-week history of high grade fever, fatigue and confusion which began abruptly two days after a cystoscopy procedure. Past medical history included pulmonary sarcoidosis diagnosed by mediastinal lymph biopsy, diabetes and hypertension. On admission he was febrile and confused with stable vital signs. Initial workup included negative Head CT and lumbar puncture. Blood work revealed normal metabolic and liver function tests with progressive anemia, thrombocytopenia and atypical lymphocytosis of 15-20%...
2017: IDCases
https://www.readbyqxmd.com/read/28069071/sporadic-cases-of-adult-measles-a-research-article
#11
Ranjan Premaratna, Nathasha Luke, Harsha Perera, Mahesh Gunathilake, Pubudu Amarasena, T G A Nilmini Chandrasena
BACKGROUND: Measles caused by a paramyxovirus, characterized by fever, malaise, cough, coryza conjunctivitis, a maculopapular rash is known to result in pneumonia, encephalitis and death. Fatal cases of measles in Sri Lanka are rare after implementation of the National Immunization Programme in 1984. Thereafter 0.1% case fatality rate was observed during October 1999-June 2000 which is a very low figure compared to other regional countries. Immunization guidelines were further revised in 2001, 2011 and in 2012 when additional immunization was recommended to age group 4-21 years; who are likely to have inadequate immunization, in order to achieve elimination of Measles by 2020...
January 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28061758/score-risk-model-for-predicting-severe-fever-with-thrombocytopenia-syndrome-mortality
#12
Li Wang, Zhiqiang Zou, Chunguo Hou, Xiangzhong Liu, Fen Jiang, Hong Yu
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging epidemic infectious disease with high mortality in East Aisa, especially in China. To predict the prognosis of SFTS precisely is important in clinical practice. METHODS: From May 2013 to November 2015, 233 suspected SFTS patients were tested for SFTS virus using RT-PCR. Cox regression model was utilized to comfirm independent risk factors for mortality. A risk score model for mortality was constructed based on regression coefficient of risk factors...
January 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28057140/-spatial-analysis-and-prediction-of-severe-fever-with-thrombocytopenia-syndrome-in-zhejiang-province-2011-2015
#13
H C Wu, X P Xu, C Wu, Q B Lu, Z Y Ding, J F Lin
Objective: To understand the distribution of the severe fever with thrombocytopenia syndrome (SFTS) in Zhejiang province, and predict the incidence and the probability of SFTS outbreak. Methods: Based on the cases of SFTS from 2011-2015, software ArcGIS 10.0 was used to analyze the spatial distribution, Moran's I and Getis-Ord Gi were used to analyze the spatial autocorrelation. The incidence trend was explored by trend surface analysis, and the prediction was made by Kriging interpolation. Results: The incidence of SFTS increased and the distribution expanded in Zhejiang from 2011 to 2015, the seasonal and the demographic characteristics of SFTS were similar to the previous research; there were regional clustering of the cases (P<0...
November 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28043314/hepatitis-b-leading-to-megaloblastic-anemia-and-catastrophic-peripheral-thrombocytopenia
#14
Muhammad Hafeez, Tariq Sarfraz, Raja Ghayas Khan, Abdul Rafe, Ghulam Rasool, Kamran Nazir Ahmed
Hepatitis B virus (HBV) typically causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma. It is associated with a variety of extrahepatic complications. We herein, present a rare extrahepatic complication of HBV infection. A 32-year man presented with melena, bleeding from gums and fever. Peripheral blood examination revealed anemia, macrocytosis and severe thrombocytopenia. His hepatitis B surface antigen (HBsAg) was positive but deoxyribonucleic acid (HBV DNA) by polymerase chain reaction (PCR) was negative...
December 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28036115/development-and-validation-of-a-real-time-reverse-transcriptase-pcr-assay-for-sensitive-detection-of-sftsv
#15
Peibin Zeng, Zhendong Yang, Sonia Bakkour, Bingjun Wang, Shuli Qing, Jingxing Wang, Limin Chen, Michael Busch, Hua Shan, Jing Liu, Tzong-Hae Lee
BACKGROUND: Severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) is an emerging tick-borne RNA virus recently identified as the pathogen that causes severe fever with thrombocytopenia syndrome (SFTS) in China. The existing commercial nucleic acid testing (comNAT) assay with a relatively high claimed limit of quantitative detection (LOQD) is not capable of sensitive detection and quantitation of SFTSV. Thus, a new real-time reverse transcriptase (RT)-PCR assay with improved sensitivity is needed for clinical diagnosis; it could also be used to screen blood donors if necessary...
December 30, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/28033338/severe-fever-with-thrombocytopenia-syndrome-in-south-korea-2013-2015
#16
Seong Jin Choi, Sang-Won Park, In-Gyu Bae, Sung-Han Kim, Seong Yeol Ryu, Hyun Ah Kim, Hee-Chang Jang, Jian Hur, Jae-Bum Jun, Younghee Jung, Hyun-Ha Chang, Young Keun Kim, Jongyoun Yi, Kye-Hyung Kim, Jeong-Hwan Hwang, Yeon-Sook Kim, Hye Won Jeong, Kyoung-Ho Song, Wan Beom Park, Eu Suk Kim, Myoung-Don Oh
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was recently identified in China, South Korea and Japan. The objective of the study was to evaluate the epidemiologic and clinical characteristics of SFTS in South Korea. METHODS/PRINCIPAL FINDINGS: SFTS is a reportable disease in South Korea. We included all SFTS cases reported to the Korea Centers for Disease Control and Prevention (KCDC) from January 2013 to December 2015...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28033271/a-simple-and-practical-score-model-for-predicting-the-mortality-of-severe-fever-with-thrombocytopenia-syndrome-patients
#17
Shue Xiong, Wenjing Zhang, Mingyue Li, Yan Xiong, Mengmeng Li, Hua Wang, Dongliang Yang, Cheng Peng, Xin Zheng
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging disease with a high fatality rate. The risk factors for death are not clearly identified, and there is no clinical score model to predict the prognosis. We retrospectively collected the clinical information of clinical symptoms and laboratory parameters of SFTS patients on admission. After analyzing the clinical characteristics of 179 SFTS patients, we found that an elevated level of neurologic symptoms, respiratory symptoms, viral load, and a lower level of monocyte percentage were the critical risk factors for mortality...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28033261/elevated-thrombopoietin-and-platelet-indices-confirm-active-thrombopoiesis-but-fail-to-predict-clinical-severity-of-puumala-hantavirus-infection
#18
Outi Laine, Lotta Joutsi-Korhonen, Riitta Lassila, Heini Huhtala, Antti Vaheri, Satu Mäkelä, Jukka Mustonen
We evaluated the mechanisms of thrombocytopenia and procoagulant changes in relation with clinical variables in a cohort of patients with acute hantavirus disease.Blood samples of 33 prospectively recruited, consecutive, hospitalized patients with acute Puumala virus-induced hemorrhagic fever with renal syndrome (HFRS) were collected acutely and at the recovery visit (control). Serum thrombopoietin (TPO) and activity of plasma microparticles (MPs) from various cell sources were measured with enzyme-linked immunosorbent assay-based methods...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28024959/clinicopathologic-immunophenotyping-and-cytogenetic-analysis-of-sweet-syndrome-in-egyptian-patients-with-acute-myeloid-leukemia
#19
Mohamed El-Khalawany, Soha Aboeldahab, Al-Sadat Mosbeh, Aida Thabet
BACKGROUND: Sweet syndrome (SS) is an uncommon dermatologic disorder that could be associated with hematologic malignancies. OBJECTIVE: To describe the clinicopathologic, immunophenotyping and cytogenetic characteristics of SS in Egyptian patients with acute myeloid leukemia (AML). METHODS: The study was conducted during the period from April 2011 to March 2015. For each patient, a clinical evaluation and histological assessment of cutaneous lesions were recorded...
October 26, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28003599/establishment-of-subclones-of-severe-fever-with-thrombocytopenia-syndrome-virus-yg1-strain-selected-by-the-degree-of-low-ph-dependent-cell-fusion-activity
#20
Sanae Nishio, Yoshimi Tsuda, Ryo Ito, Kenta Shimizu, Kumiko Yoshimatsu, Jiro Arikawa
Severe fever with thrombocytopenia syndrome virus YG1 strain was isolated from the first clinical case in Japan. We found that only some of the cells underwent low-pH-dependent cell fusion, though all of the cells were confirmed to have been infected with viruses, suggesting that YG1 strain consists of heterogeneous mixtures of related viruses. Here, we established three subclones, E3, A4 and B7, from YG1 strain by the limiting dilution method with pH-dependent cell fusion activities. Subclone E3 showed weak fusion activity and cytopathic effect (CPE) in Vero E6 cells...
December 22, 2016: Japanese Journal of Infectious Diseases
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