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https://www.readbyqxmd.com/read/27720288/variation-in-the-intensity-of-care-for-patients-with-uncomplicated-renal-colic-presenting-to-u-s-emergency-departments
#1
Joshua W Elder, M Kit Delgado, Benjamin I Chung, Elizabeth A Pirrotta, N Ewen Wang
BACKGROUND: Renal colic results in > 1 million ED visits per year, yet there exists a gap in understanding how the majority of these visits, namely uncomplicated cases, are managed. OBJECTIVE: We assessed patient- and hospital-level variation for emergency department (ED) management of uncomplicated kidney stones. METHODS: We identified ED visits from non-elderly adults (aged 19-79 years) with a primary diagnosis indicating renal stone or colic from the 2011 Nationwide Emergency Department Sample...
December 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27695663/adolescent-cellphone-use-while-driving-an-overview-of-the-literature-and-promising-future-directions-for-prevention
#2
M Kit Delgado, Kathryn J Wanner, Catherine McDonald
Motor vehicle crashes are the leading cause of death in adolescents, and drivers aged 16-19 are the most likely to die in distracted driving crashes. This paper provides an overview of the literature on adolescent cellphone use while driving, focusing on the crash risk, incidence, risk factors for engagement, and the effectiveness of current mitigation strategies. We conclude by discussing promising future approaches to prevent crashes related to cellphone use in adolescents. Handheld manipulation of the phone while driving has been shown to have a 3 to 4-fold increased risk of a near crash or crash, and eye glance duration greater than 2 seconds increases crash risk exponentially...
June 16, 2016: Media and Communication
https://www.readbyqxmd.com/read/27667446/oxidized-ldl-cholesterol-statin-use-and-morbidity-mortality-in-patients-receiving-maintenance-hemodialysis
#3
Sandra Wagner, Mugurel Apetrii, Ziad A Massy, Kleber E Marcus, Graciela E Delgado, Scharnagel Hubert, März Winfried, Marie Metzger, Patrick Rossignol, Alan Jardine, Hallvard Holdaas, Bengt Fellström, Roland Schmieder, Bénédicte Stengel, Faiez Zannad
Statin treatment reduces the risk of cardiovascular mortality in the general population, but it has little or no benefit in hemodialyzed patients (HD). This may reflect different underlying pathophysiology of CVD in patients treated with HD, maybe involving the oxidative stress. Our aim was to assess the association of oxidized LDL (oxLDL), determinated by Mercodia oxLDL ELISA Kit, with major adverse cardiac events (MACE) and all-cause mortality in HD patients based on the AURORA trial (rosuvastatin vs placebo), and patients not on HD from the LURIC study...
September 25, 2016: Free Radical Research
https://www.readbyqxmd.com/read/27604134/whole-exome-sequencing-analysis-reveals-trpv3-as-a-risk-factor-for-cardioembolic-stroke
#4
Caty Carrera, Jordi Jiménez-Conde, Sophia Derdak, Kelly Rabionet, Cristofol Vives-Bauzá, Carolina Soriano-Tárrega, Eva Giralt-Steinhauer, Marina Mola-Caminal, Rosa M Diaz-Navarro, Silvia Tur, Elena Muiño, Cristina Gallego-Fabrega, Sergi Beltran, Jaume Roquer, Agustin Ruiz, Oscar Sotolongo-Grau, Jurek Krupinski, Jin-Moo Lee, Carlos Cruchaga, Pilar Delgado, Rainer Malik, Brad B Worrall, Sudha Seshadri, Joan Montaner, Israel Fernández-Cadenas
Genetic studies suggest that hundreds of genes associated with stroke remain unidentified. Exome sequencing proves useful for finding new genes associated with stroke. We aimed to find new genetic risk factors for cardioembolic stroke by analysing exome sequence data using new strategies. For discovery, we analysed 42 cardioembolic stroke cases and controls with extreme phenotypes (cohort 1), and for replication, 32 cardioembolic stroke cases and controls (cohort 2) using the SeqCapExome capture kit. We then analysed the replicated genes in two new cohorts that comprised 834 cardioembolic strokes and controls (cohort 3) and 64,373 cardioembolic strokes and controls (cohort 4)...
November 30, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27587425/perceptions-of-family-participation-in-intensive-care-unit-rounds-and-telemedicine-a-qualitative-assessment
#5
Elisabeth A Stelson, Brendan G Carr, Kate E Golden, Niels Martin, Therese S Richmond, M Kit Delgado, Daniel N Holena
BACKGROUND: Family-centered rounds involve purposeful interactions between patients' families and care providers to refocus the delivery of care on patients' needs. OBJECTIVES: To examine perspectives of patients' family members and health care providers on family participation in rounds in the surgical intensive care unit (ICU) and the potential use of telemedicine to facilitate this process. METHODS: Patients' family members and surgical ICU care providers were recruited for semistructured interviews exploring stakeholders' perspectives on family participation in ICU rounds and the potential role of telemedicine...
September 2016: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/27524804/hla-genotyping-in-the-clinical-laboratory-comparison-of-next-generation-sequencing-methods
#6
T Profaizer, E Lázár-Molnár, D W Close, J C Delgado, A Kumánovics
Implementation of human leukocyte antigen (HLA) genotyping by next-generation sequencing (NGS) in the clinical lab brings new challenges to the laboratories performing this testing. With the advent of commercially available HLA-NGS typing kits, labs must make numerous decisions concerning capital equipment and address labor considerations. Therefore, careful and unbiased evaluation of available methods is imperative. In this report, we compared our in-house developed HLA NGS typing with two commercially available kits from Illumina and Omixon using 10 International Histocompatibility Working Group (IHWG) and 36 clinical samples...
July 2016: HLA
https://www.readbyqxmd.com/read/27510605/evaluation-of-phosphatidylserine-dependent-antiprothrombin-antibody-testing-for-the-diagnosis-of-antiphospholipid-syndrome-results-of-an-international-multicentre-study
#7
O Amengual, R Forastiero, M Sugiura-Ogasawara, K Otomo, K Oku, C Favas, J Delgado Alves, P Žigon, A Ambrožič, M Tomšič, I Ruiz-Arruza, G Ruiz-Irastorza, M L Bertolaccini, G L Norman, Z Shums, J Arai, A Murashima, A E Tebo, M Gerosa, P L Meroni, I Rodriguez-Pintó, R Cervera, J Swadzba, J Musial, T Atsumi
OBJECTIVE: A task force of scientists at the International Congress on Antiphospholipid Antibodies recognized that phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) might contribute to a better identification of antiphospholipid syndrome (APS). Accordingly, initial and replication retrospective, cross-sectional multicentre studies were conducted to ascertain the value of aPS/PT for APS diagnosis. METHODS: In the initial study (eight centres, seven countries), clinical/laboratory data were retrospectively collected...
August 10, 2016: Lupus
https://www.readbyqxmd.com/read/27460511/recurrent-violent-injury-magnitude-risk-factors-and-opportunities-for-intervention-from-a-statewide-analysis
#8
Elinore Kaufman, Kristin Rising, Douglas J Wiebe, David J Ebler, Marie L Crandall, M Kit Delgado
INTRODUCTION: Although preventing recurrent violent injury is an important component of a public health approach to interpersonal violence and a common focus of violence intervention programs, the true incidence of recurrent violent injury is unknown. Prior studies have reported recurrence rates from 0.8% to 44%, and risk factors for recurrence are not well established. METHODS: We used a statewide, all-payer database to perform a retrospective cohort study of emergency department visits for injury due to interpersonal violence in Florida, following up patients injured in 2010 for recurrence through 2012...
September 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27386120/late-prostatic-metastasis-of-an-uveal-melanoma-in-a-miniature-schnauzer-dog
#9
Esmeralda Delgado, João X Silva, Hugo Pissarra, Maria C Peleteiro, Richard R Dubielzig
This manuscript describes a previously unreported clinical case of canine uveal melanoma in a miniature Schnauzer dog with an unusual location of metastasis (prostate) and delayed occurrence (3 years after primary tumor diagnosis and enucleation). Immunohistochemical labeling of both tumors with Melan A, Ki-67, and c-kit added some valuable information.
July 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27178369/cost-effectiveness-of-field-trauma-triage-among-injured-adults-served-by-emergency-medical-services
#10
Craig D Newgard, Zhuo Yang, Daniel Nishijima, K John McConnell, Stacy A Trent, James F Holmes, Mohamud Daya, N Clay Mann, Renee Y Hsia, Tom D Rea, N Ewen Wang, Kristan Staudenmayer, M Kit Delgado
BACKGROUND: The American College of Surgeons Committee on Trauma sets national targets for the accuracy of field trauma triage at ≥95% sensitivity and ≥65% specificity, yet the cost-effectiveness of realizing these goals is unknown. We evaluated the cost-effectiveness of current field trauma triage practices compared with triage strategies consistent with the national targets. STUDY DESIGN: This was a cost-effectiveness analysis using data from 79,937 injured adults transported by 48 emergency medical services agencies to 105 trauma and nontrauma hospitals in 6 regions of the western United States from 2006 through 2008...
June 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/26927882/national-differences-in-regional-emergency-department-boarding-times-are-us-emergency-departments-prepared-for-a-public-health-emergency
#11
Jennifer S Love, David Karp, M Kit Delgado, Gregg Margolis, Douglas J Wiebe, Brendan G Carr
OBJECTIVES: Boarding admitted patients decreases emergency department (ED) capacity to accommodate daily patient surge. Boarding in regional hospitals may decrease the ability to meet community needs during a public health emergency. This study examined differences in regional patient boarding times across the United States and in regions at risk for public health emergencies. METHODS: A retrospective cross-sectional analysis was performed by using 2012 ED visit data from the American Hospital Association (AHA) database and 2012 hospital ED boarding data from the Centers for Medicare and Medicaid Services Hospital Compare database...
August 2016: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/26573899/failure-to-rescue-in-trauma-coming-to-terms-with-the-second-term
#12
Daniel N Holena, Emily Earl-Royal, M Kit Delgado, Carrie A Sims, Jose L Pascual, Jesse Y Hsu, Brendan G Carr, Patrick M Reilly, Douglas Wiebe
INTRODUCTION: The failure to rescue (FTR) rate is the probability of death after a major complication and was defined in elective surgical cohorts. In elective surgery, the precedence rate (proportion of deaths preceded by major complications) approaches 100%, but recent studies in trauma report rates of only 20-25%. We hypothesised that use of high quality data would result precedence rates in higher than those derived from national datasets, and we further sought to characterise the nature of those deaths not preceded by major complications...
January 2016: Injury
https://www.readbyqxmd.com/read/26330022/challenges-and-opportunities-for-implementing-evidence-based-antenatal-care-in-mozambique-a-qualitative-study
#13
Adriano Biza, Ingeborg Jille-Traas, Mercedes Colomar, Maria Belizan, Jennifer Requejo Harris, Beatrice Crahay, Mario Merialdi, My Huong Nguyen, Fernando Althabe, Alicia Aleman, Eduardo Bergel, Alicia Carbonell, Leonardo Chavane, Therese Delvaux, Diederike Geelhoed, Metin Gülmezoglu, Celsa Regina Malapende, Armando Melo, Nafissa Bique Osman, Mariana Widmer, Marleen Temmerman, Ana Pilar Betrán
BACKGROUND: Maternal mortality remains a daunting problem in Mozambique and many other low-resource countries. High quality antenatal care (ANC) services can improve maternal and newborn health outcomes and increase the likelihood that women will seek skilled delivery care. This study explores the factors influencing provider uptake of the recommended package of ANC interventions in Mozambique. METHODS: This study used qualitative research methods including key informant interviews with stakeholders from the health sector and a total of five focus group discussions with women with experience with ANC or women from the community...
September 2, 2015: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/25843813/-c-kit-in-gastrointestinal-stromal-tumors-and-associated-malignancies-a-study-in-a-population-with-genetic-isolation
#14
Diana Rodríguez-González, Luciano Delgado-Plasencia, Carmen Hernández-León, Esther Torres-Monzón, María Elisa Castro-Peraza, Josefina Cruz-Jurado, Alberto Bravo-Gutiérrez, Vicente Medina-Arana
INTRODUCTION: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Numerous studies have reported the association between GIST and other neoplasms. OBJECTIVES: The aim of this study was to investigate the possible association between GIST and other tumors in a genetically isolated population. METHODS: A retrospective study was conducted of patients with GIST between 2002 and 2009 at our center...
October 2015: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/25377400/patient-and-trauma-center-characteristics-associated-with-helicopter-emergency-medical-services-transport-for-patients-with-minor-injuries-in-the-united-states
#15
MULTICENTER STUDY
Brian H Cheung, M Kit Delgado, Kristan L Staudenmayer
BACKGROUND: Helicopter emergency medical services (EMS) transport is expensive, and previous work has shown that cost-effective use of this resource is dependent on the proportion of minor injuries flown. To understand how overtriage to helicopter EMS versus ground EMS can be reduced, it is important to understand factors associated with helicopter transport of patients with minor injuries. OBJECTIVES: The aim was to characterize patient and hospital characteristics associated with helicopter transport of patients with minor injuries...
November 2014: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/25200789/technical-note-advantages-and-limitations-of-authenticating-palmera-goat-dairy-products-by-pyrosequencing-the-melanocortin-1-receptor-mc1r-gene
#16
B Badaoui, A Manunza, A Castelló, M D'Andrea, F Pilla, J Capote, J Jordana, A Ferrando, A Martínez, B Cabrera, J V Delgado, V Landi, M Gómez, A Pons, M El Ouni, O Vidal, M Amills
Inferring the breed of origin of dairy products can be achieved through molecular analysis of genetic markers with a population-specific pattern of segregation. The goal of the current work was to generate such markers in goats by resequencing several pigmentation genes [melanocortin 1 receptor (MC1R), v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), tyrosinase (TYR), and tyrosinase-related protein 2 (TYRP2)]. This experiment revealed 10 single nucleotide polymorphisms (SNP), including 5 missense mutations and 1 nonsense mutation...
November 2014: Journal of Dairy Science
https://www.readbyqxmd.com/read/25146204/-norovirus-detection-in-children-with-community-acquired-or-nosocomial-diarrhea-at-guillermo-grant-benavente-hospital-in-concepci%C3%A3-n-chile
#17
Sonia Montenegro, Susana Pineda, Isabel Enríquez, Nancy Enríquez, Nancy Rivera, Carolina Delgado
INTRODUCTION: Norovirus (NoV) are RNA viruses highly contagious, stable in the environment, genetically variable, and the most common cause of viral sporadic acute gastroenteritis worldwide. This is the first study carried out in Concepcion, Chile, to investigate the presence of NoV as an etiologic agent of viral diarrheas in hospitalized children. Objective. To detect the presence and genogroup of NoV in children with diarrhea and to compare it with rotavirus (RV) and adenovirus (AdV)...
June 2014: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/25035763/availability-of-insurance-linkage-programs-in-u-s-emergency-departments
#18
Mia Kanak, M Kit Delgado, Carlos A Camargo, N Ewen Wang
INTRODUCTION: As millions of uninsured citizens who use emergency department (ED) services are now eligible for health insurance under the Affordable Care Act, the ED is ideally situated to facilitate linkage to insurance. Forty percent of U.S. EDs report having an insurance linkage program. This is the first national study to examine the characteristics of EDs that offer or do not offer these programs. METHODS: This was a secondary analysis of data from the National Survey for Preventive Health Services in U...
July 2014: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25035750/characteristics-of-united-states-emergency-departments-that-routinely-perform-alcohol-risk-screening-and-counseling-for-patients-presenting-with-drinking-related-complaints
#19
Michael A Yokell, Carlos A Camargo, N Ewen Wang, M Kit Delgado
INTRODUCTION: Emergency department (ED) screening and counseling for alcohol misuse have been shown to reduce at-risk drinking. However, barriers to more widespread adoption of this service remain unclear. METHODS: We performed a secondary analysis of a nationwide survey of 277 EDs to determine the proportion of EDs that routinely perform alcohol screening and counseling among patients presenting with alcohol-related complaints and to identify potential institutional barriers and facilitators to routine screening and counseling...
July 2014: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/24713343/c-kit-identifies-a-subpopulation-of-mesenchymal-stem-cells-in-adipose-tissue-with-higher-telomerase-expression-and-differentiation-potential
#20
A Blazquez-Martinez, M Chiesa, F Arnalich, J Fernandez-Delgado, M Nistal, M P De Miguel
The stromal vascular fraction (SVF) of adipose tissue is an easy to obtain source of adipose tissue-derived stem cells (ADSCs). We and others have achieved significant but suboptimal therapeutic effects with ADSCs in various settings, mainly due to low rates of differentiation into specific cell types and with the downside of undesired side effects as a consequence of the undifferentiated ADSCs. These data prompted us to find new stem cell-specific markers for ADSCs and/or subpopulations with higher differentiation potential to specific lineages...
March 2014: Differentiation; Research in Biological Diversity
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