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https://www.readbyqxmd.com/read/29851207/measuring-emergency-care-survival-the-implications-of-risk-adjusting-for-race-and-poverty
#1
Kimon L H Ioannides, Avi Baehr, David N Karp, Douglas J Wiebe, Brendan G Carr, Daniel N Holena, M Kit Delgado
OBJECTIVES: We determined the impact of including race, ethnicity, and poverty in risk adjustment models for emergency care sensitive conditions mortality that could be used for hospital pay-for-performance initiatives. We hypothesized that adjusting for race, ethnicity, and poverty would bolster rankings for hospitals that cared for a disproportionate share of non-white, Hispanic, or poor patients. METHODS: We performed a cross-sectional analysis patients admitted from the emergency department to 157 hospitals in Pennsylvania with trauma, sepsis, stroke, cardiac arrest, and ST-elevation myocardial infarction...
May 31, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29760538/gastrointestinal-stromal-tumors-a-multidisciplinary-challenge
#2
REVIEW
Juan Manuel Sanchez-Hidalgo, Manuel Duran-Martinez, Rafael Molero-Payan, Sebastian Rufian-Peña, Alvaro Arjona-Sanchez, Angela Casado-Adam, Antonio Cosano-Alvarez, Javier Briceño-Delgado
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors located in the alimentary tract. Its usual manifestation is gastrointestinal bleeding. However, small asymptomatic lesions are frequently detected as incidental finding. Characteristically, most GISTs (> 95%) are positive for the KIT protein (CD117) by IHC staining and approximately 80%-90% of GISTs carry a mutation in the c-KIT or PDGFRA genes. Mutational analysis should be performed when planning adjuvant and neoadjuvant therapy, due to its possible resistance to conventional treatment...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29685369/quality-through-coopetition-an-empiric-approach-to-measure-population-outcomes-for-emergency-care-sensitive-conditions
#3
Brendan G Carr, Austin S Kilaru, David N Karp, M Kit Delgado, Douglas J Wiebe
STUDY OBJECTIVE: We develop a novel approach for measuring regional outcomes for emergency care-sensitive conditions. METHODS: We used statewide inpatient hospital discharge data from the Pennsylvania Healthcare Cost Containment Council. This cross-sectional, retrospective, population-based analysis used International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes to identify admissions for emergency care-sensitive conditions (ischemic stroke, ST-segment elevation myocardial infarction, out-of-hospital cardiac arrest, severe sepsis, and trauma)...
April 20, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29652523/attitudes-on-technological-social-and-behavioral-economic-strategies-to-reduce-cellphone-use-among-teens-while-driving
#4
M Kit Delgado, Catherine C McDonald, Flaura K Winston, Scott D Halpern, Alison M Buttenheim, Claudia Setubal, Yanlan Huang, Kathryn A Saulsgiver, Yi-Ching Lee
OBJECTIVE: The majority of U.S. teens admit to handheld cellphone use while driving, an increasingly common cause of crashes. Attitudes toward novel cellphone applications and settings that block use while driving are poorly understood, potentially limiting uptake. We examined teens' willingness to reduce cellphone use while driving and perceptions of potential strategies to limit this behavior. METHODS: Teen drivers (n = 153) aged 16-17 who owned smartphones and admitted to texting while driving completed an online survey...
April 13, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29555646/cell-extrinsic-hematopoietic-impact-of-ezh2-inactivation-in-fetal-liver-endothelial-cells
#5
Wen Hao Neo, Christopher A G Booth, Emanuele Azzoni, Lijun Chi, Paul Delgado-Olguín, Marella F T R de Bruijn, Sten Eirik W Jacobsen, Adam J Mead
Despite the well-established cell-intrinsic role of epigenetic factors in normal and malignant hematopoiesis, their cell-extrinsic role remains largely unexplored. Herein we investigated the hematopoietic impact of inactivating Ezh2 , a key component of polycomb repressive complex 2 (PRC2), in the fetal liver (FL) vascular niche. Hematopoietic specific ( Vav -iCre) Ezh2 inactivation enhanced FL hematopoietic stem cell (HSC) expansion with normal FL erythropoiesis. In contrast, endothelium ( Tie2 -Cre) targeted Ezh2 inactivation resulted in embryonic lethality with severe anemia at embryonic day 13...
May 17, 2018: Blood
https://www.readbyqxmd.com/read/29548520/corrigendum-to-factors-associated-with-hospital-admission-after-an-emergency-department-treat-and-release-visit-for-older-adults-with-injuries-am-j-emerg-med-35-9-2017-1252-1257
#6
Emily C Earl-Royal, Elinore J Kaufman, Alexandra L Hanlon, Daniel N Holena, Kristin L Rising, M Kit Delgado
No abstract text is available yet for this article.
March 13, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29501610/comparative-effectiveness-of-initial-treatment-at-trauma-center-vs-neurosurgery-capable-non-trauma-center-for-severe-isolated-head-injury
#7
Elinore J Kaufman, Ashkan Ertefaie, Dylan S Small, Daniel N Holena, M Kit Delgado
BACKGROUND: Head injury is an increasing contributor to death and disability, particularly among the elderly. Older patients are less likely to be treated at trauma centers, and head injury is the most common severe injury treated at non-trauma centers. We hypothesized that patients initially triaged to trauma centers would have lower rates of mortality and higher rates of discharge home without services than those treated at non-trauma centers. STUDY DESIGN: We used the State Emergency Department and Inpatient Databases (2011 to 2012) for 6 states to conduct a retrospective cohort study of patients with severe, isolated head injury...
May 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29385605/effect-of-level-of-soluble-fiber-and-n-6-n-3-fatty-acid-ratio-on-performance-of-rabbit-does-and-their-litters
#8
Rebeca Delgado, Rodrigo Abad-Guamán, Nuria Nicodemus, María Jesús Villamide, Noemí Ruiz-López, Rosa Carabaño, David Menoyo, Javier García
The aim of this work was to study whether the dietary supplementation with soluble fiber (SF) and the reduction of the n-6/n-3 fatty acid ratio or the combination of both influences the survival, body and milk composition, and reproductive performance of rabbit does during the first four parturitions. Four diets in a 2 × 2 factorial arrangement were used with two levels of SF (7.8 vs. 13.0, on dry matter [DM] basis; high soluble fiber [HSF] and low soluble fiber [LSF]) and two different n-6/n-3 fatty acid ratios (13...
April 3, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29340937/association-between-electronic-medical-record-implementation-of-default-opioid-prescription-quantities-and-prescribing-behavior-in-two-emergency-departments
#9
M Kit Delgado, Frances S Shofer, Mitesh S Patel, Scott Halpern, Christopher Edwards, Zachary F Meisel, Jeanmarie Perrone
No abstract text is available yet for this article.
January 16, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29280066/diagnostic-accuracy-of-11-c-methionine-pet-in-detecting-neuropathologically-confirmed-recurrent-brain-tumor-after-radiation-therapy
#10
Annika Kits, Heather Martin, Alejandro Sanchez-Crespo, Anna F Delgado
OBJECTIVE: This study aims to determine the diagnostic test accuracy (DTA) of11 C-methionine (MET) PET in the discrimination between recurrent tumor and radiation-induced injury in neuropathologically confirmed cases. METHODS: A retrospective cohort of 30 patients with previously irradiated intracranial tumors (23 gliomas, 6 metastases, and 1 meningioma) was included. All patients underwent a preoperative MET PET and postoperative neuropathological analysis. Maximum and mean standardized uptake values (SUV) were obtained in the lesion, in the contralateral mirror region, and in the contralateral frontal cortex...
February 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29055613/which-transfers-can-we-avoid-multi-state-analysis-of-factors-associated-with-discharge-home-without-procedure-after-ed-to-ed-transfer-for-traumatic-injury
#11
Laura N Medford-Davis, Daniel N Holena, David Karp, Michael J Kallan, M Kit Delgado
OBJECTIVE: Among injured patients transferred from one emergency department (ED) to another, we determined factors associated with being discharged from the second ED without procedures, or admission or observation. METHODS: We analyzed all patients with injury diagnosis codes transferred between two EDs in the 2011 Healthcare Utilization Project State Emergency Department and State Inpatient Databases for 6 states. Multivariable hierarchical logistic regression evaluated the association between patient (demographics and clinical characteristics) and hospital factors, and discharge from the second ED without coded procedures...
May 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28892764/a-european-multicientre-study-on-the-comparison-of-hbv-viral-loads-between-veris-hbv-assay-and-roche-cobas-%C3%A2-taqman-%C3%A2-hbv-test-abbott-realtime-hbv-assay-siemens-versant-hbv-assay-and-qiagen-artus-hbv-rg-kit
#12
Patrick Braun, Rafael Delgado, Monica Drago, Diana Fanti, Hervé Fleury, Jacques Izopet, Alessandra Lombardi, MaAngeles Marcos, Karine Sauné, Siobhan O'Shea, Alfredo Pérez-Rivilla, John Ramble, Pascale Trimoulet, Jordi Vila, Duncan Whittaker, Alain Artus, Daniel Rhodes
BACKGROUND: Hepatitis B viral load testing is essential to treatment and monitoring decisions in patients with chronic Hepatitis B. Beckman Coulter has developed the VERIS HBV Assay (Veris) for use on the fully automated DxN VERIS Molecular Diagnostics System.(1) OBJECTIVES: To evaluate the clinical performance of the Veris HBV Assay at multiple EU laboratories STUDY DESIGN: Method comparison was performed with a total of 344 plasma specimens from HBV infected patients tested with Veris and COBAS(®) TaqMan(®) HBV Test (Cobas), 207 specimens tested with Veris and RealTime HBV Assay (RealTime), 86 specimens tested with Veris and VERSANT(®) HBV Assay (Versant), and 74 specimens tested with Veris and artus(®) HBV RG PCR kit (artus)...
September 8, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28661715/patient-characteristics-and-temporal-trends-in-police-transport-of-blunt-trauma-patients-a-multicenter-retrospective-cohort-study
#13
Elinore J Kaufman, Sara F Jacoby, Catherine E Sharoky, Brendan G Carr, M Kit Delgado, Patrick M Reilly, Daniel N Holena
BACKGROUND: Police transport (PT) of penetrating trauma patients has the potential to decrease prehospital times for patients with life-threatening hemorrhage and is part of official policy in Philadelphia, Pennsylvania. We hypothesized that rates of PT of bluntly injured patients have increased over the past decade. METHODS: We used Pennsylvania Trauma Outcomes Study registry data from 2006-15 to identify bluntly injured adult patients transported to all 8 trauma centers in Philadelphia...
November 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28633356/ridesharing-and-motor-vehicle-crashes-in-4-us-cities-an-interrupted-time-series-analysis
#14
Christopher N Morrison, Sara F Jacoby, Beidi Dong, M Kit Delgado, Douglas J Wiebe
Uber, the world's largest ridesharing company, has reportedly provided over 2 billion journeys globally since operations began in 2010; however, the impact on motor vehicle crashes is unclear. Theoretically, ridesharing could reduce alcohol-involved crashes in locations where other modes of transportation are less attractive than driving one's own vehicle while under the influence of alcohol. We conducted interrupted time-series analyses using weekly counts of injury crashes and the proportion that were alcohol-involved in 4 US cities (Las Vegas, Nevada; Reno, Nevada; Portland, Oregon; and San Antonio, Texas)...
February 1, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28556460/hla-genotyping-using-the-illumina-hla-trusight-next-generation-sequencing-kits-a-comparison
#15
T Profaizer, E Lázár-Molnár, A Pole, J C Delgado, A Kumánovics
Illumina first introduced their TruSight human leucocyte antigen (HLA) next-generation sequencing (NGS) typing kit in 2015 and subsequently followed up with a new version in 2016. Here we report on our experience comparing the two versions of the Illumina HLA NGS kits.
August 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28541852/the-pennsylvania-trauma-outcomes-study-risk-adjusted-mortality-model-results-of-a-statewide-benchmarking-program
#16
Douglas J Wiebe, Daniel N Holena, M Kit Delgado, Nathan McWilliams, Juliet Altenburg, Brendan G Carr
Trauma centers need objective feedback on performance to inform quality improvement efforts. The Trauma Quality Improvement Program recently published recommended methodology for case mix adjustment and benchmarking performance. We tested the feasibility of applying this methodology to develop risk-adjusted mortality models for a statewide trauma system. We performed a retrospective cohort study of patients ≥16 years old at Pennsylvania trauma centers from 2011 to 2013 (n = 100,278). Our main outcome measure was observed-to-expected mortality ratios (overall and within blunt, penetrating, multisystem, isolated head, and geriatric subgroups)...
May 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28538625/a-metric-of-our-own-failure-to-rescue-after-trauma
#17
Daniel N Holena, Elinore J Kaufman, M Kit Delgado, Douglas J Wiebe, Brendan G Carr, Jason D Christie, Patrick M Reilly
BACKGROUND: Failure to rescue (FTR) is defined as death after an adverse event. The original metric was derived in elective surgical populations and reclassifies deaths not preceded by recorded adverse events as FTR cases under the assumption these deaths resulted from missed adverse events. This approach lacks face validity in trauma because patients often die without adverse events as a direct result of injury. Another common approach simply excludes deaths without recorded adverse events, but this approach reduces the reliability of the FTR metric...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28431492/anti-drug-antibodies-in-colombian-patients-with-rheumatoid-arthritis-treated-with-enbrel-vs-etanar-preliminary-report
#18
Benjamín Reyes-Beltrán, Gabriela Delgado
The present study was undertaken to detect antibodies against etanercept (ETN) in a group of Colombian patients with rheumatoid arthritis (RA) and being treated with Enbrel(®) vs. Etanar(®). From these patients with RA, clinical and laboratory data were collected and serum taken for anti-drug antibody (ADAb) analysis. Samples from 32 patients (16 who had been treated with Enbrel(®) and 16 with Etanar(®)) were analyzed. Positive sera for ADAb were found in six of the 32 subjects (18.7%); five (31.2%) in the Enbrel(®) group and one (6...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28423170/us-emergency-department-encounters-for-law-enforcement-associated-injury-2006-2012
#19
Elinore J Kaufman, David N Karp, M Kit Delgado
No abstract text is available yet for this article.
June 1, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28410919/factors-associated-with-hospital-admission-after-an-emergency-department-treat-and-release-visit-for-older-adults-with-injuries
#20
Emily C Earl-Royal, Elinore J Kaufman, Alexandra L Hanlon, Daniel N Holena, Kristin L Rising, M Kit Delgado
INTRODUCTION: Emergency Department (ED) visits for injury often precede hospital admissions in older adults, but risk factors for these admissions are poorly characterized. We sought to determine the incidence and risk factors for hospitalization shortly following discharge home from an ED visit for traumatic injury in older adults. We hypothesized higher risk for admission in those with increased age, discharged home after falls, with increased comorbidity burden, and who live in poor neighborhoods...
September 2017: American Journal of Emergency Medicine
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