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Pulmonar hypertension

Nadine Al-Naamani, Gaudalupe Espitia H, Hugo Velazquez-Moreno, Benjamin Macuil-Chazaro, Arturo Serrano-Lopez, Ricardo S Vega-Barrientos, Nicholas S Hill, Ioana R Preston
INTRODUCTION: Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by precapillary pulmonary hypertension secondary to vaso-occlusive pulmonary vasculopathy and is classified as Pulmonary Hypertension Group 4. The aim of this study is to report the clinical experience of CTEPH in Mexico. METHODS: Consecutive patients diagnosed with CTEPH were identified from the Registro de Pacientes con Hipertension Pulmonar del Instituto de Seguridad y Servicio Social de los Trabajadores del Estado (REPHPISSSTE) registry between January 2009 and February 2014...
April 2016: Lung
Núria Coll-Bonfill, Melina Mara Musri, Victor Ivo, Joan Albert Barberà, Olga Tura-Ceide
Pulmonary artery remodelling it is a major feature of pulmonary hypertension (PH). It is characterised by cellular and structural changes of the pulmonary arteries causing higher pulmonar vascular resistance and right ventricular failure. Abnormal deposition of smooth muscle-like (SM-like) cells in normally non-muscular, small diameter vessels and a deregulated control of endothelial cells are considered pathological features of PH. The origin of the SM-like cells and the mechanisms underlying the development and progression of this remodelling process are not understood...
2015: American Journal of Stem Cells
Diego de Faria Magalhães Torres, Walter Araujo Zin, Agnaldo José Lopes, Patrícia dos Santos Vigário, Marcelo Iorio Garcia, Daniel Waetge, Marcelo Luiz da Silva Bandeira, Luiz Gustavo Pignataro Bessa, Fernando Silva Guimarães
BACKGROUND: No studies have described and evaluated the association between hemodynamics, physical limitations and quality of life in patients with pulmonary hypertension (PH) without concomitant cardiovascular or respiratory disease. OBJECTIVE: To describe the hemodynamic profile, quality of life and physical capacity of patients with PH from groups I and IV and to study the association between these outcomes. METHODS: Cross-sectional study of patients with PH from clinical groups I and IV and functional classes II and III undergoing the following assessments: hemodynamics, exercise tolerance and quality of life...
May 2015: Arquivos Brasileiros de Cardiologia
Carmen Navarro
Pulmonary involvement in systemic sclerosis. Alveolitis, fibrosis and pulmonar arterial hypertension Lung disease is present in most of the patients with systemic sclerosis and is now the most important cause of mortality. Interstitial lung disease and pulmonary hypertension are, so far, the main disorders found and both are difficult to detect at the earliest stages. However, diagnostic tools such as immunological test, lung function test, high resolution CT, bronchoalveolar lavage, echocardiography, right-side cardiac catheterization, or lung biopsy are necessary to accurately evaluate the clinical status and allow to improve the management organ-specific ad hoc...
November 2006: Reumatología Clinica
Carlos Gilberto Canelo Aybar, José Luís Cuadra Urteaga, F Fujii, Franco Romaní Romaní, Fernando Alonso Atencia Matute, Rogger Oscar Verona Rubio
The tumour pulmonary micro-embolism is a rare condition characterized by the occlusion of pulmonary small arteries, arteriolas, and alveolar capillaries septales, accompanied of trombosis. Occasionally the development of pulmonary hypertension is the first manifestation of an occult neoplasia, in series of autopsies, an incidence from 3 to 26% has been reported in solid tumors, being clinical evident in 8%. Few cases have documented the development of this condition in patients with carcinoma hepatocelular, we report the case of a 16-year-old male who comes to the emergency with signs of cardiac insufficiency and cor pulmonare whose anatomopatological study confirmed a tumour massive microembolic compromise at pulmonary level and hepatocarcinoma...
January 2008: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
C Bustíos, M Dávalos, R Román, E Zumaeta
BACKGROUND: Liver cirrhosis is an important cause of morbidity and mortality all around the world. In Peru it is the 5th cause of general mortality and the 2nd one between all those related to gastrointestinal and hepatobiliary diseases. At HNERM it is the principal etiology between all the cases that need hospitalization in gastroenterology. It is clear that we need to know all the clinical and epidemiologic characteristics to propose national actions to try to control and prevent this disease...
July 2007: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
M T Riccardi, A Chialà, F Lannone, V Grattagliano, M Covelli, G Lapadula
In systemic sclerosis (SSc) occurrence of recurrent digital ulcers (DU) is cause of pain and functional disability of hands. Treatment with vasodilator agents, such as calcium channel blockers, ACE inhibitors, prostanoids, has not shown to be an effective therapy. There is evidence that endotelin-1 (ET-1) is a key mediator in regulation of vascular tone and its enhanced production in SSc is believed to lead to vasoconstriction, vessel remodelling, local ischemia and ulcers of fingertips. Recently, an oral endothelin receptor antagonist, bosentan, has been proved to be effective in the treatment of SSc associated pulmonar arterial hypertension (PAH) and to decrease the development of new DU in patients with SSc...
April 2007: Reumatismo
Nazzareno Galiè, Adam Torbicki, Robyn Barst, Philippe Dartevelle, Sheila Haworth, Tim Higenbottam, Horst Olschewski, Andrew Peacock, Giuseppe Pietra, Lewis J Rubin, Gerald Simonneau
No abstract text is available yet for this article.
May 2005: Revista Española de Cardiología
N Galiè, M Sanguinetti, C Marrozzini, B Magnani
Vasodilator agents have been used to decrease pulmonary arterial pressure in patients with chronic thromboembolic pulmonary hypertension (CTPH). A case is reported of a patient who had a severe hemodynamic deterioration after 10 mg of sublingual nifedipine. A review of cases of CTPH treated with vasodilators is also discussed.
October 1985: Giornale Italiano di Cardiologia
B Kringsholm, P Christoffersen
Lung and heart sections from 33 drug addicts submitted for medico-legal autopsy at the Institute of Forensic Medicine in Copenhagen were studied together with tissue sections from 20 'normal' persons. In the drug addict cases focal bleedings in lung tissue were found in 94%, signs of earlier bleedings, haemosiderin containing histiocytes, were seen in 91%, and focal fibrosis in 46%. The bleeding episodes may be due to hypoxia in connection with heroin intake. In 94% of the drug addicts birefringent material in lung tissue was demonstrated, in 58% in granulomas and giant cells, in 27% in giant cells only and in 9% in isolated histiocytes...
May 1987: Forensic Science International
C Belaise, N Annicchiarico, G Camerota, G Occhi
The authors evaluated the respiratory capacity of 73 patients with untreated scoliosis of varying etiology, site, age and severity. Twenty-six of these patients were also evaluated from a haemodynamic point of view by means of a right cardiac catheterisation. The results, in conformity with the most significant data reported in the literature, confirm that scoliosis causes cardiorespiratory insufficiency of varying extent in relation to age of onset, site and severity. The initial respiratory deficit is of the restrictive type and is fairly well tolerated...
June 1988: Italian Journal of Orthopaedics and Traumatology
V Rozsíval, J Kvasnicka, Z Bĕlobrádek, H Skopecková, I Gajdosová, P Rejchrt, J Simek
Authors have been catheterized a total of 36 patients with isolated aortal stenosis. In 14 from them (38%), the mean pression value in pulmonar artery was ranged as over 25 torrs (3.33 kPa). It was proved on the statistical evaluation of hemodynamic data that the pulmonar hypertension is correlated with the pression on the end of diastola of the left ventricle (correlation coefficient r = 0.89), being irrelated of the extent of aortal gradient, bed surface, heart index, age, pulmonar vascular resistence and functional classification...
1990: Sborník Vědeckých Prací Lékařské Fakulty Karlovy Univerzity V Hradci Králové. Supplementum
A Saadjian, M Gueunoun, F Philip-Joët, A Magnan, A Ebagosti, L Garbe, A Arnaud, S Levy
Severe pulmonary hypertension presenting as acute cor pulmonare was observed in a HIV positive heroin addict. The usual aetiological investigations were negative. The apparently primary pulmonary hypertension was resistant oxygen and vasodilator therapy and was fatal in 6 months. Anatomopathological examination revealed the presence of talc microemboli in the pulmonary arterioles, severe medial hypertrophy and fibrous subendothelial thickening. The presence of the talc suggests that the pulmonary hypertension in this case was due to obstruction of the pulmonary vascular bed by the obstructive arterial lesions, despite the context of HIV infection...
September 1991: Archives des Maladies du Coeur et des Vaisseaux
S Pavlović, V Petrović, N Kozarević, D Sobić, V Bosnjakovć
A patient with symptoms of coronary artery disease is presented. ECG changes, chest X-ray, echocardiography as well as ventilation-perfusion study excluded coronary artery disease and confirmed cor pulmonare chronicum and pulmonary hypertension. Patophysiological aspects and clinical symptoms are also discussed.
January 1991: Plućne Bolesti: the Journal of Yugoslav Association of Phthisiology and Pneumology
W M Zapol, M T Snider
We repeatedly assessed pulmonary and systemic hemodynamics in 30 patients undergoing therapy for severe acute respiratory failure of diverse causes. Pulmonary-artery hypertension and elevated pulmonar vascular resistance were observed in all patients after correction of systemic hypoxemia. Increasing pulmonary blood flow by isoproterenol infusion or decreasing pulmonary blood flow by partial bypass of the right side of the heart minimally altered pulmonary-artery pressure. Although neither elevated pulmonary vascular resistance nor low cardiac index reliably predicted death, survivors had preogressive decreases of pulmonary vascular resistance with time, whereas nonsurvivors tended to maintain or increase pulmonary vascular resistance...
March 3, 1977: New England Journal of Medicine
J Widimský
No abstract text is available yet for this article.
February 1978: Vnitr̆ní Lékar̆ství
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