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https://www.readbyqxmd.com/read/28297568/safety-studies-for-use-of-adipose-tissue-derived-mesenchymal-stromal-stem-cells-in-a-rabbit-model-for-osteoarthritis-to-support-a-phase-i-clinical-trial
#1
Scott M Riester, Janet M Denbeigh, Yang Lin, Dakota L Jones, Tristan de Mooij, Eric A Lewallen, Hai Nie, Christopher R Paradise, Darcie J Radel, Amel Dudakovic, Emily T Camilleri, Dirk R Larson, Wenchun Qu, Aaron J Krych, Matthew A Frick, Hee-Jeong Im, Allan B Dietz, Jay Smith, Andre J van Wijnen
Adipose-derived mesenchymal stem cells (AMSCs) offer potential as a therapeutic option for clinical applications in musculoskeletal regenerative medicine because of their immunomodulatory functions and capacity for trilineage differentiation. In preparation for a phase I clinical trial using AMSCs to treat patients with osteoarthritis, we carried out preclinical studies to assess the safety of human AMSCs within the intra-articular joint space. Culture-expanded human AMSCs grown in human platelet-lysate were delivered via intra-articular injections into normal healthy rabbit knees and knees at risk for the development of osteoarthritis after bilateral medial anterior hemimeniscectomy...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28290190/disruption-in-bone-marrow-fat-may-attenuate-testosterone-action-on-muscle-size-after-spinal-cord-injury-a-case-report
#2
Ashraf S Gorgey, Pamela D Moore, Rodney C Wade, Ranjodh S Gill, Timothy Lavis, Robert A Adler
BACKGROUND: Mesenchymal stem cells can be differentiated into muscle satellite cells. Testosterone replacement therapy (TRT) promotes the differentiation of satellite cells into muscle cells. CASE REPORT: A 31 year old male with a T4 complete chronic spinal cord injury (SCI) had fixation for a mid-shaft fracture of the left femur. The participant received transdermal testosterone patches (4mg/day) daily for 16 weeks. Skeletal muscle and yellow bone marrow adiposity cross-sectional areas (CSAs) of both thighs were measured using magnetic resonance imaging...
March 13, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28278383/3d-printed-poly-%C3%AE%C2%B5-caprolactone-scaffold-augmented-with-mesenchymal-stem-cells-for-total-meniscal-substitution
#3
Zheng-Zheng Zhang, Shao-Jie Wang, Ji-Ying Zhang, Wen-Bo Jiang, Ai-Bing Huang, Yan-Song Qi, Jian-Xun Ding, Xue-Si Chen, Dong Jiang, Jia-Kuo Yu
BACKGROUND: Total meniscectomy leads to knee osteoarthritis in the long term. The poly(ε-caprolactone) (PCL) scaffold is a promising material for meniscal tissue regeneration, but cell-free scaffolds result in relatively poor tissue regeneration and lead to joint degeneration. HYPOTHESIS: A novel, 3-dimensional (3D)-printed PCL scaffold augmented with mesenchymal stem cells (MSCs) would offer benefits in meniscal regeneration and cartilage protection. STUDY DESIGN: Controlled laboratory study...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28258177/stem-cell-injections-in-knee-osteoarthritis-a-systematic-review-of-the-literature
#4
REVIEW
Haiko Imfl Pas, Marinus Winters, Hidde J Haisma, Martinus Jj Koenis, Johannes L Tol, Maarten H Moen
OBJECTIVE: Stem cell injection for knee osteoarthritis (KOA) is an emerging new therapy, and we aimed to review its evidence of efficacy. DESIGN: Systematic review. ELIGIBILITY CRITERIA: Criteria for eligibility were randomised controlled trials (RCTs) and non-RCT on the efficacy of stem cell injections in KOA. All references were checked for missed articles. DATA SOURCES: MEDLINE, EMBASE, CINAHL, Web of Science, Cochrane Library, PEDro and SPORTDiscus were searched...
March 3, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28243954/knee-cartilage-regeneration-with-umbilical-cord-mesenchymal-stem-cells-embedded-in-collagen-scaffold-using-dry-arthroscopy-technique
#5
B Sadlik, G Jaroslawski, D Gladysz, M Puszkarz, M Markowska, K Pawelec, D Boruczkowski, T Oldak
Articular cartilage injuries lead to progressive degeneration of the joint with subsequent progression to osteoarthritis, which currently becomes a serious health and economic issue. Due to limited capability for self-regeneration, cartilage repair remains a challenge for the present-day orthopedics. Currently, available therapeutic methods fail to provide satisfactory results. A search for other strategies that could regenerate a hyaline-like tissue with a durable effect and adequate mechanical properties is underway...
February 28, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28224299/clinical-impact-of-sarcopenia-and-relevance-of-nutritional-intake-in-patients-before-and-after-allogeneic-hematopoietic-stem-cell-transplantation
#6
Shouichi Tanaka, Osamu Imataki, Atsuo Kitaoka, Shuji Fujioka, Etsuyo Hanabusa, Yumiko Ohbayashi, Makiko Uemura, Nobuo Arima, Tetsuji Yamamoto
PURPOSE: We conducted a retrospective study to evaluate the effect of rehabilitation on minimizing sarcopenia during hematopoietic stem cell transplantation (HSCT) therapy. METHODS: We developed a protocol to test for retention of physical function during HSCT. Muscle strength, muscle circumference, and muscle function before and after HSCT were measured. Consecutive patients with hematological malignancies who underwent HSCT treatment were recruited in this research...
February 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28220548/relationship-of-physical-activity-with-physical-function-and-health-related-quality-of-life-in-patients-having-undergone-allogeneic-haematopoietic-stem-cell-transplantation
#7
S Morishita, K Kaida, S Yamauchi, T Wakasugi, K Ikegame, H Ogawa, K Domen
In this study, we investigated the differences in physical activity before and after transplantation, and the relationship between physical activity and physical function and health-related quality of life (QOL) in 30 patients who underwent allogeneic haematopoietic stem cell transplantation (allo-HSCT). Duration and intensity of physical activity were quantified using a three-dimensional accelerometer. Physical function was quantified by handgrip and knee-extensor strength, with the 6-minute walk test (6MWT) used as a measure of exercise capacity...
February 21, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28203597/intra-articular-implantation-of-mesenchymal-stem-cells-part-1-a-review-of-the-literature-for-prevention-of-postmeniscectomy-osteoarthritis
#8
Matthew J Kraeutler, Justin J Mitchell, Jorge Chahla, Eric C McCarty, Cecilia Pascual-Garrido
Osteoarthritis (OA) after a partial or total meniscectomy procedure is a common pathology. Because of the high incidence of meniscectomy in the general population, as well as the significant burden of knee OA, there is increasing interest in determining methods for delaying postmeniscectomy OA. Biological therapies, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and platelet-rich plasma (PRP), have been proposed as possible therapies that could delay OA in this and other settings...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28203596/intra-articular-implantation-of-mesenchymal-stem-cells-part-2-a-review-of-the-literature-for-meniscal-regeneration
#9
Matthew J Kraeutler, Justin J Mitchell, Jorge Chahla, Eric C McCarty, Cecilia Pascual-Garrido
Knee osteoarthritis (OA) after partial or total meniscectomy is a prevalent issue that patients must face. Various methods of replacing meniscal tissue have been studied to avoid this progression, including meniscal allograft transplantation, meniscal scaffolds, and synthetic meniscus replacement. Studies have shown that meniscal scaffolds may improve symptoms but have not been shown to prevent progression of OA. Recently, mesenchymal stem cells (MSCs) have been proposed as a possible biological therapy for meniscal regeneration...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28191757/cartilage-regeneration-in-osteoarthritic-patients-by-a-composite-of-allogeneic-umbilical-cord-blood-derived-mesenchymal-stem-cells-and-hyaluronate-hydrogel-results-from-a-clinical-trial-for-safety-and-proof-of-concept-with-7-years-of-extended-follow-up
#10
Yong-Beom Park, Chul-Won Ha, Choong-Hee Lee, Young Cheol Yoon, Yong-Geun Park
Few methods are available to regenerate articular cartilage defects in patients with osteoarthritis. We aimed to assess the safety and efficacy of articular cartilage regeneration by a novel medicinal product composed of allogeneic human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs). Patients with Kellgren-Lawrence grade 3 osteoarthritis and International Cartilage Repair Society (ICRS) grade 4 cartilage defects were enrolled in this clinical trial. The stem cell-based medicinal product (a composite of culture-expanded allogeneic hUCB-MSCs and hyaluronic acid hydrogel [Cartistem]) was applied to the lesion site...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28186682/repair-of-torn-avascular-meniscal-cartilage-using-undifferentiated-autologous-mesenchymal-stem-cells-from-in-vitro-optimization-to-a-first-in-human-study
#11
Michael R Whitehouse, Nicholas R Howells, Michael C Parry, Eric Austin, Wael Kafienah, Kyla Brady, Allen E Goodship, Jonathan D Eldridge, Ashley W Blom, Anthony P Hollander
Meniscal cartilage tears are common and predispose to osteoarthritis (OA). Most occur in the avascular portion of the meniscus where current repair techniques usually fail. We described previously the use of undifferentiated autologous mesenchymal stem cells (MSCs) seeded onto a collagen scaffold (MSC/collagen-scaffold) to integrate meniscal tissues in vitro. Our objective was to translate this method into a cell therapy for patients with torn meniscus, with the long-term goal of delaying or preventing the onset of OA...
December 15, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28185322/a-difunctional-regeneration-scaffold-for-knee-repair-based-on-aptamer-directed-cell-recruitment
#12
Xiaoxia Hu, Yulan Wang, Yaning Tan, Jie Wang, Haoyang Liu, Yingqian Wang, Shuang Yang, Miusi Shi, Shiyong Zhao, Yufeng Zhang, Quan Yuan
To solve the challenge of poor knee repair, an aptamer-bilayer scaffold is designed for autologous mesenchymal stem cell (MSC) recruitment and osteochondral regeneration. The scaffold can efficiently recruit MSCs to the defect and induce the directional differentiation of MSCs, thus successfully achieving simultaneous regeneration of cartilage and bone in the knee joint.
February 10, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28177194/concise-review-mesenchymal-stem-cells-for-functional-cartilage-tissue-engineering-taking-cues-from-chondrocyte-based-constructs
#13
Andrea R Tan, Clark T Hung
Osteoarthritis, the most prevalent form of joint disease, afflicts 9% of the U.S. population over the age of 30 and costs the economy nearly $100 billion annually in healthcare and socioeconomic costs. It is characterized by joint pain and dysfunction, though the pathophysiology remains largely unknown. Due to its avascular nature and limited cellularity, articular cartilage exhibits a poor intrinsic healing response following injury. As such, significant research efforts are aimed at producing engineered cartilage as a cell-based approach for articular cartilage repair...
February 8, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28170179/comparative-clinical-observation-of-arthroscopic-microfracture-in-the-presence-and-absence-of-a-stromal-vascular-fraction-injection-for-osteoarthritis
#14
Phu Dinh Nguyen, Tung Dang-Xuan Tran, Huynh Ton-Ngoc Nguyen, Hieu Trung Vu, Phuong Thi-Bich Le, Nhan Lu-Chinh Phan, Ngoc Bich Vu, Ngoc Kim Phan, Phuc Van Pham
Osteoarthritis (OA) is a degenerative cartilage disease that is characterized by a local inflammatory reaction. Consequently, many studies have been performed to identify suitable prevention and treatment interventions. In recent years, both arthroscopic microfracture (AM) and stem cell therapy have been used clinically to treat OA. This study aimed to evaluate the clinical effects of AM in the presence and absence of a stromal vascular fraction (SVF) injection in the management of patients with OA. Thirty patients with grade 2 or 3 (Lawrence scale) OA of the knee participated in this study...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28154888/permanent-knee-sensorimotor-system-changes-following-acl-injury-and-surgery
#15
John Nyland, Collin Gamble, Tiffany Franklin, David N M Caborn
The cruciate ligaments are components of the knee capsuloligamentous system providing vital neurosensory and biomechanical function. Since most historical primary ACL repair attempts were unsuccessful, reconstruction has become the preferred surgery. However, an increased understanding of the efficacy of lesion-site scaffolding, innovative suturing methods and materials, and evolving use of biological healing mediators such as platelet-rich plasma and stem cells has prompted reconsideration of what was once believed to be impossible...
February 2, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28148266/restoration-of-a-large-osteochondral-defect-of-the-knee-using-a-composite-of-umbilical-cord-blood-derived-mesenchymal-stem-cells-and-hyaluronic-acid-hydrogel-a-case-report-with-a-5-year-follow-up
#16
Yong-Beom Park, Chul-Won Ha, Choong-Hee Lee, Yong-Geun Park
BACKGROUND: The treatment of articular cartilage defects is a therapeutic challenge for orthopaedic surgeons. Furthermore, large osteochondral defects needs restoration of the underlying bone for sufficient biomechanical characteristics as well as the overlying cartilage. CASE PRESENTATION: A symptomatic large osteochondral defect in the knee joint was restored using a composite of umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) 0.5 x 10(7)/ml and 4% hyaluronic acid (HA) hydrogel...
February 2, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28128708/detection-of-stem-cell-transplant-rejection-with-ferumoxytol-mr-imaging-correlation-of-mr-imaging-findings-with-those-at-intravital-microscopy
#17
Heike E Daldrup-Link, Carmel Chan, Olga Lenkov, Seyedmeghdad Taghavigarmestani, Toktam Nazekati, Hossein Nejadnik, Fanny Chapelin, Aman Khurana, Xinming Tong, Fan Yang, Laura Pisani, Michael Longaker, Sanjiv Sam Gambhir
Purpose To determine whether endogenous labeling of macrophages with clinically applicable nanoparticles enables noninvasive detection of innate immune responses to stem cell transplants with magnetic resonance (MR) imaging. Materials and Methods Work with human stem cells was approved by the institutional review board and the stem cell research oversight committee, and animal experiments were approved by the administrative panel on laboratory animal care. Nine immunocompetent Sprague-Dawley rats received intravenous injection of ferumoxytol, and 18 Jax C57BL/6-Tg (Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6) 2Bck/J mice received rhodamine-conjugated ferumoxytol...
January 27, 2017: Radiology
https://www.readbyqxmd.com/read/28124993/growth-hormone-gh-and-rehabilitation-promoted-distal-innervation-in-a-child-affected-by-caudal-regression-syndrome
#18
Jesús Devesa, Alba Alonso, Natalia López, José García, Carlos I Puell, Tamara Pablos, Pablo Devesa
Caudal regression syndrome (CRS) is a malformation occurring during the fetal period and mainly characterized by an incomplete development of the spinal cord (SC), which is often accompanied by other developmental anomalies. We studied a 9-month old child with CRS who presented interruption of the SC at the L2-L3 level, sacral agenesis, a lack of innervation of the inferior limbs (flaccid paraplegia), and neurogenic bladder and bowel. Given the known positive effects of growth hormone (GH) on neural stem cells (NSCs), we treated him with GH and rehabilitation, trying to induce recovery from the aforementioned sequelae...
January 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28124102/in-vitro-chondrogenic-potential-of-synovial-stem-cells-and-chondrocytes-allocated-for-autologous-chondrocyte-implantation-a-comparison-synovial-stem-cells-as-an-alternative-cell-source-for-autologous-chondrocyte-implantation
#19
Eva Johanna Kubosch, Emanuel Heidt, Philipp Niemeyer, Anke Bernstein, Norbert P Südkamp, Hagen Schmal
PURPOSE: The use of passaged chondrocytes is the current standard for autologous chondrocyte implantation (ACI). De-differentiation due to amplification and donor site morbidity are known drawbacks highlighting the need for alternative cell sources. METHODS: Via clinically validated flow cytometry analysis, we compared the expression of human stem cell and cartilage markers (collagen type 2 (Col2), aggrecan (ACAN), CD44) of chondrocytes (CHDR), passaged chondrocytes for ACI (CellGenix™), bone marrow derived mesenchymal stem cells (BMSC), and synovial derived stem cells (SDSC)...
January 25, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28115945/isolation-and-characterization-of-synovial-mesenchymal-stem-cell-derived-from-hip-joints-a-comparative-analysis-with-a-matched-control-knee-group
#20
Akihisa Hatakeyama, Soshi Uchida, Hajime Utsunomiya, Manabu Tsukamoto, Hirotaka Nakashima, Eiichiro Nakamura, Cecilia Pascual-Garrido, Ichiro Sekiya, Akinori Sakai
Purpose. To determine the characteristics of MSCs from hip and compare them to MSCs from knee. Methods. Synovial tissues were obtained from both the knee and the hip joints in 8 patients who underwent both hip and knee arthroscopies on the same day. MSCs were isolated from the knee and hip synovial samples. The capacities of MSCs were compared between both groups. Results. The number of cells per unit weight at passage 0 of synovium from the knee was significantly higher than that from the hip (P < 0.05)...
2017: Stem Cells International
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