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JOURNAL ARTICLE
Mingwei Wei, Libai Lu, Zongjiang Luo, Jiasheng Ma, Jianchu Wang
OBJECTIVES: Cuproptosis represents an innovative type of cell death, distinct from apoptosis, driven by copper dependency, yet the involvement of copper apoptosis-associated long non-coding RNAs (CRLncRNAs) in hepatocellular carcinoma (HCC) remains unclear. This study is dedicated to unveiling the role and significance of these copper apoptosis-related lncRNAs within the context of HCC, focusing on their impact on both the development of the disease and its prognosis. METHODS: We conducted an analysis of gene transcriptomic and clinical data for HCC cases by sourcing information from The Cancer Genome Atlas database...
April 23, 2024: BMC Gastroenterology
#2
JOURNAL ARTICLE
Tingting Wu, Ruiqian Gao, Xiaowei Wang, Dong Guo, Yuwei Xie, Bingzi Dong, Xiwei Hao, Chengzhan Zhu
BACKGROUND: Persistent pancreaticobiliary reflux (PBR) is associated with a high risk of biliary malignancy. This study aimed to evaluate the proportion of PBR in biliary tract diseases and mechanisms by which PBR promoted cholangiocarcinoma progression. METHODS: Overall 227 consecutive patients with primary biliary tract disease participated in this study. The amylase levels in the collected bile were analyzed. The mechanisms underlying the effect of high-amylase bile on bile duct epithelial and cholangiocarcinoma cells progression were analyzed...
April 22, 2024: Translational Oncology
#3
JOURNAL ARTICLE
Alexandra Dunn, Sangeeta Rao, Brian Husbands, Nicholas Petrovitch, Samantha Loeber, Tobias Schwarz, Kelsey Cline, Wilfried Mai, Heather Spain, Kaitlin Curran, Kate Vickery, Angela Marolf
Exocrine pancreatic carcinomas are uncommon in dogs and cats, and diagnosis with diagnostic imaging can be challenging. This retrospective, multi-institutional, descriptive study was performed to evaluate the CT features of exocrine pancreatic carcinomas. The CT examinations of 18 dogs and 12 cats with exocrine pancreatic carcinomas diagnosed by cytology or histopathology were reviewed. The CT features of exocrine pancreatic carcinomas included a well-defined mass in 28/30 (93%) with contrast enhancement in 27/30 (90%), commonly heterogeneous 22/30 (73%); often with a nonenhancing fluid to soft tissue attenuating center 12/30 (40%)...
April 22, 2024: Veterinary Radiology & Ultrasound
#4
JOURNAL ARTICLE
David J Fei-Zhang, Samuel J Schellenberg, David J Bentrem, Jeffrey D Wayne, Timothy M Pawlik
BACKGROUND: Social conditions and dietary behaviors have been implicated in the rising burden of gastrointestinal cancers (GIC). The "food environment" reflects influences on a community level relative to food availability, nutritional assistance, and social determinants of health. Using the US Department of Agriculture-Food Environment Atlas (FEA), we sought to characterize the association of food environment on GIC presenting stage and long-term survival. METHODS: Patients diagnosed with GIC between 2013 and 2017 were identified using the SEER database...
April 22, 2024: Journal of Surgical Oncology
#5
JOURNAL ARTICLE
Mitsuru Kinoshita, Yutaka Takeda, Yoshiaki Ohmura, Yoshiteru Katsura, Go Shinke, Shu Aoyama, Yukari Kihara, Kiminori Yanagisawa, Shinsuke Katsuyama, Ryo Ikeshima, Masayuki Hiraki, Keijiro Sugimura, Toru Masuzawa, Taishi Hata, Kohei Murata
A 91-year-old man had a history of cholecystectomy and choledochostomy for cholecystolithiasis and choledocholithiasis. Eleven years earlier, intrahepatic stones were found in the posterior bile duct, and he did not wish to undergo treatment. Over time, worsening of the intrahepatic stones and dilation of the intrahepatic bile duct were observed. At 91 years old, enhanced abdominal CT revealed wall thickening of the hilar bile duct, and MRCP showed stenosis of the hilar bile duct. Endoscopic retrograde cholangiography showed no contrast in the right intrahepatic bile duct and marked dilation of the left intrahepatic bile duct...
April 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#6
Hao Chi, Xiaodong Yan, Wen Tong, Qing Tian
Intraductal papillary mucinous neoplasm of the bile tract is a rare biliary tumor characterized by mucin growth within the bile duct. In the early stages, it often presents without significant obstruction, this often leads to its discovery in the advanced stages. We report a case of a 63-year-old female with an intraductal papillary mucinous neoplasm of the bile duct (IPMN-B). The patient had a history of intrahepatic bile duct stones and biliary ascariasis. She gradually developed symptoms such as jaundice and intermittent fever before admission, and a bile duct biopsy confirmed the diagnosis of IPMN-B...
April 18, 2024: Photodiagnosis and Photodynamic Therapy
#7
JOURNAL ARTICLE
Wenbo Ma, Jinqiang Zhang, Weina Chen, Nianli Liu, Tong Wu
BACKGROUND: Cholangiocarcinoma (CCA) is a highly malignant cancer of the biliary tract with poor prognosis. Further mechanistic insights into the molecular mechanisms of CCA are needed to develop more effective target therapy. METHODS: The expression of the histone lysine acetyltransferase KAT2B in human CCA was analyzed in human CCA tissues. CCA xenograft was developed by inoculation of human CCA cells with or without KAT2B overexpression into SCID mice. Western blotting, ChIP-qPCR, qRT-PCR, protein immunoprecipitation, GST pull-down and RNA-seq were performed to delineate KAT2B mechanisms of action in CCA...
April 19, 2024: Journal of Experimental & Clinical Cancer Research: CR
#8
JOURNAL ARTICLE
Jiao Su, Yuanhao Liang, Xiaofeng He
OBJECTIVES: Our aim was to explore the disease burden caused by gallbladder and biliary tract cancer globally, regionally, and nationally, by age and sex. METHODS: The absolute number of cases and age-standardized rates (ASR) of incidence, prevalence, mortality, and disability-adjusted life years (DALYs) due to gallbladder and biliary tract cancer were extracted from the Global Burden of Disease (GBD) Study 2019. We estimated the trends in disease burden by calculating the percentage change in the absolute number of cases and the estimated annual percentage change (EAPC) in ASR, by social development index (SDI), region, nation, sex, and age...
2024: Frontiers in Medicine
#9
REVIEW
Changhoon Yoo, Jaewon Hyung, Stephen L Chan
BACKGROUND: The incidence of intrahepatic cholangiocarcinoma (IHCCA) is rising around the world. The disease is becoming a major global health issue. Conventionally, most patients with cholangiocarcinoma present with advanced disease and systemic therapy is the mainstay of treatment. This review discusses recent advances in systemic treatments for patients with IHCCA. SUMMARY: The addition of durvalumab to a gemcitabine plus cisplatin regimen has significantly improved overall survival in the phase 3 TOPAZ-1 trial and is currently recommended as a standard first-line treatment...
April 2024: Liver Cancer
#10
JOURNAL ARTICLE
Xiaofen Li, Nan Zhou, Yu Yang, Zijian Lu, Hongfeng Gou
Biliary tract cancer (BTC) is a highly aggressive malignancy with limited second-line therapy. We conducted this phase 2 trial to evaluate the efficacy and safety of second-line nab-paclitaxel plus sintilimab in advanced BTC. Histologically confirmed advanced BTC patients with documented disease progression after first-line chemotherapy were enrolled. Subjects received nab-paclitaxel 125 mg/m2 on days 1 and 8 plus sintilimab 200 mg on day 1, administered every 3 weeks. The primary end point was the objective response rate (ORR)...
April 18, 2024: Cancer Science
#11
JOURNAL ARTICLE
Pei-Chien Tsai, Chung-Feng Huang, Ming-Lun Yeh, Meng-Hsuan Hsieh, Hsing-Tao Kuo, Chao-Hung Hung, Kuo-Chih Tseng, Hsueh-Chou Lai, Cheng-Yuan Peng, Jing-Houng Wang, Jyh-Jou Chen, Pei-Lun Lee, Rong-Nan Chien, Chi-Chieh Yang, Gin-Ho Lo, Jia-Horng Kao, Chun-Jen Liu, Chen-Hua Liu, Sheng-Lei Yan, Chun-Yen Lin, Wei-Wen Su, Cheng-Hsin Chu, Chih-Jen Chen, Shui-Yi Tung, Chi-Ming Tai, Chih-Wen Lin, Ching-Chu Lo, Pin-Nan Cheng, Yen-Cheng Chiu, Chia-Chi Wang, Jin-Shiung Cheng, Wei-Lun Tsai, Han-Chieh Lin, Yi-Hsiang Huang, Chi-Yi Chen, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Wan-Long, Ming-Jong Bair, Ming-Lung Yu
BACKGROUNDS AND AIM: Chronic hepatitis C (CHC) patients who fail antiviral therapy have a high risk of developing hepatocellular carcinoma (HCC). We investigated the effects of metformin and statins, commonly used to treat diabetes mellitus (DM) and hyperlipidemia (HLP), on HCC risk in CHC patients who failed antiviral therapy. METHODS: CHC patients with failed interferon-based therapy were enrolled in a large-scale multicenter cohort study in Taiwan (T-COACH). HCC occurrence 1...
April 19, 2024: Clinical and Molecular Hepatology
#12
REVIEW
Yanjun Sun, Junfeng Gong, Zhuang Li, Lin Han, Dengqun Sun
Gallbladder cancer is a common type of biliary tract tumor. Optimal management for early stage cases typically involves radical excision as the primary treatment modality. Various surgical techniques, including laparoscopic, robotic, and navigational surgery, have demonstrated favorable clinical outcomes in radical gallbladder excision. Unfortunately, most patients are ineligible for surgical intervention because of the advanced stage of the disease upon diagnosis. Consequently, non-surgical interventions, such as chemotherapy, radiotherapy, immunotherapy, and targeted therapy, have become the mainstay of treatment for patients in advanced stages...
April 18, 2024: Postgraduate Medicine
#13
JOURNAL ARTICLE
Yoshiko Fukunishi, Atsushi Hiraoka, Fujimasa Tada, Mai Fukumoto, Takuya Matsuda, Kana Matsuoka, Kosuke Nakatani, Emi Yanagihara, Hironobu Saneto, Hirofumi Izumoto, Taisei Murakami, Kei Onishi, Shogo Kitahata, Kozue Kanemitsu-Okada, Tomoe Kawamura, Taira Kuroda, Hideki Miyata, Eiji Tsubouchi, Jun Hanaoka, Jota Watanabe, Hiromi Ohtani, Osamu Yoshida, Masashi Hirooka, Masanori Abe, Bunzo Matsuura, Tomoyuki Ninomiya, Yoichi Hiasa
BACKGROUND AND AIM: Rapidly aging societies have become a major issue worldwide including Japan. This study aimed to elucidate relative changes in the characteristics of inpatients in Japan related to this issue. METHODS: A total of 23 835 Japanese inpatients treated from 2010 to 2021 were enrolled (2010-2013, period I; 2014-2017, period II; 2018-2021, period III). Changes in clinical features were retrospectively analyzed based on ICD-10 diagnosis data. RESULTS: The percentage of patients aged over 75 years increased over time (period I, 38...
April 18, 2024: Journal of Gastroenterology and Hepatology
#14
Magdalena Stepien, Talita Duarte-Salles, Veronika Fedirko, Antonia Trichopoulou, Pagona Lagiou, Christina Bamia, Kim Overvad, Anne Tjønneland, Louise Hansen, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Gianluca Severi, Tilman Kühn, Rudolf Kaaks, Krasimira Aleksandrova, Heiner Boeing, Eleni Klinaki, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Alessio Naccarati, H Bas Bueno-de-Mesquita, Petra H Peeters, Guri Skeie, Elisabete Weiderpass, Christine L Parr, José Ramón Quirós, Genevieve Buckland, Esther Molina-Montes, Pilar Amiano, Maria-Dolores Chirlaque, Eva Ardanaz, Emily Sonestedt, Ulrika Ericson, Maria Wennberg, Lena Maria Nilsson, Kay-Tee Khaw, Nick Wareham, Kathryn E Bradbury, Heather A Ward, Isabelle Romieu, Mazda Jenab
No abstract text is available yet for this article.
April 17, 2024: European Journal of Nutrition
#15
REVIEW
Yasuyuki Kawamoto, Chigusa Morizane, Yoshito Komatsu, Shunsuke Kondo, Makoto Ueno, Satoshi Kobayashi, Masayuki Furukawa, Lingaku Lee, Taroh Satoh, Daisuke Sakai, Masafumi Ikeda, Hiroshi Imaoka, Arisa Miura, Yutaka Hatanaka, Isao Yokota, Yoshiaki Nakamura, Takayuki Yoshino
Due to the widespread use of cancer genetic testing in gastrointestinal cancer, the BRCA1/2 genetic mutation has been identified in biliary tract cancer as well as pancreatic cancer. Niraparib is a poly(ADP-ribose) polymerase (PARP) inhibitor, and PARP inhibitors exert their cytotoxicity against cancer cells in the context of homologous recombination deficiency, such as BRCA mutations, via the mechanism of synthetic lethality. The aim of this phase II NIR-B trial is to evaluate the efficacy and safety of niraparib for patients with unresectable advanced or recurrent biliary tract cancer, pancreatic cancer or other gastrointestinal cancers with germline or somatic BRCA1/2 mutations revealed by genetic testing...
April 17, 2024: Future Oncology
#16
REVIEW
Current status of preoperative endoscopic biliary drainage for distal and hilar biliary obstruction.
Hirotoshi Ishiwatari, Junya Sato, Hiroki Sakamoto, Takuya Doi, Hiroyuki Ono
The purpose of preoperative biliary drainage (PBD) is to reduce complications during the perioperative period. The extrahepatic bile duct comprises distal and hilar bile ducts and assessing the need for PBD must be considered separately for each duct, as surgical procedures and morbidities vary. The representative disease-causing distal bile duct obstruction is pancreatic cancer. A randomized controlled trial has revealed that PBD carries the risk of recurrent cholangitis and pancreatitis before surgery, thus eliminating the need for PBD when early surgery is feasible...
April 17, 2024: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
#17
JOURNAL ARTICLE
Melina Boutin, Tharani Krishnan, Maria Safro, Jenny Yang, Helia Jafari, Janine M Davies, Sharlene Gill
BACKGROUND: Complete resection followed by adjuvant chemotherapy is the gold standard for patients with localized cholangiocarcinoma (CC) or gallbladder cancer (GBC). However, this is not always feasible, and recurrence rates remain high. OBJECTIVES: To understand the real-world proportions and reason for treatment failure in resected biliary tract cancers. DESIGN AND METHODS: We performed a retrospective population-based review of patients with GBC or CC [intrahepatic (IHCC) or extrahepatic (EHCC)] resected between 2005 and 2019 using the BC Cancer provincial database...
2024: Therapeutic Advances in Medical Oncology
#18
JOURNAL ARTICLE
Jiancang Ma, Yingying Feng, Jinkai Xu, Zongyu Li, Jingyue Lai, Hao Guan
BACKGROUND: The incidence of gastric cancer ranks the first among digestive tract tumors in China. However, there are no specific symptoms in the early stage of the tumor and the diagnosis process is complex, so more effective detection methods are very needed. In this study, a novel long noncoding RNA (lncRNA) was introduced as a diagnostic biomarker for gastric cancer, which brought new thinking to the exploration of its pathological mechanism and clinical prediction. METHODS: The level of lncRNA EPB41L4A-AS1 (EPB41L4A-AS1) in gastric cancer serum and cells was verified via real-time quantitative polymerase chain reaction (RT-qPCR)...
April 16, 2024: BMC Gastroenterology
#19
REVIEW
Danmei Zhang, Klara Dorman, C Benedikt Westphalen, Michael Haas, Steffen Ormanns, Jens Neumann, Max Seidensticker, Jens Ricke, Enrico N De Toni, Frederick Klauschen, Hana Algül, Timo Reisländer, Stefan Boeck, Volker Heinemann
For decades, treatment of advanced biliary tract cancer (BTC) was confined to the use of chemotherapy. In recent years however, the number of therapeutic options available for patients with unresectable BTC have drastically increased, with immunotherapy and targeted treatment gradually joining the ranks of guideline-recommended treatment regimens. The aim of the present review is to summarise the current knowledge on unresectable BTC focusing on epidemiology, anatomical distribution and current strategies for systemic treatment...
April 12, 2024: European Journal of Cancer
#20
JOURNAL ARTICLE
Julaluck Promsorn, Panjaporn Naknan, Aumkhae Sookprasert, Kosin Wirasorn, Jarin Chindaprasirt, Attapol Titapun, Piyapharom Intarawichian, Mukesh Harisinghani
OBJECTIVE: To study which radiographic features were associated with recurrence and adverse outcome in patients undergoing surgical resection of perihilar cholangiocarcinoma (PCCA), as well as to evaluate the imaging patterns that signify recurrence after the resection of PCCA. MATERIALS AND METHODS: This study was conducted in a solitary tertiary center and utilized a retrospective, analytical, case-control design. The study population consisted of patients with pathologically confirmed PCCA who underwent surgical resection and were subsequently followed up from January 2009 to December 2017...
April 15, 2024: Heliyon
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