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Biliary cancer

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https://www.readbyqxmd.com/read/29907252/opisthorchis-viverrini-draft-genome-biomedical-implications-and-future-avenues
#1
Neil D Young, Robin B Gasser
Opisthorchiasis is a neglected tropical disease of major proportion, caused by the carcinogenic, Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is known to be associated with malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Southeast Asia. No vaccine is available, and only one drug (praziquantel) is routinely employed against the parasite. Despite technological advances, little is known about the molecular biology of the fluke itself and the disease complex that it causes in humans...
2018: Advances in Parasitology
https://www.readbyqxmd.com/read/29898439/the-diagnostic-accuracy-of-cytology-for-the-diagnosis-of-hepatobiliary-and-pancreatic-cancers
#2
Marwan Al-Hajeili, Maryam Alqassas, Astabraq Alomran, Bashaer Batarfi, Bashaer Basunaid, Reem Alshail, Shahad Alaydarous, Rana Bokhary, Mahmoud Mosli
OBJECTIVE: Although cytology testing is considered a valuable method to diagnose tumors that are difficult to access such as hepato-biliary-pancreatic (HBP) malignancies, its diagnostic accuracy remains unclear. We therefore aimed to investigate the diagnostic accuracy of cytology testing for HBP tumors. STUDY DESIGN: We performed a retrospective study of all cytology samples that were used to confirm radiologically detected HBP tumors between 2002 and 2016. The cytology techniques used in our center included fine needle aspiration (FNA), brush cytology, and aspiration of bile...
June 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29896581/a-long-term-survival-case-of-advanced-biliary-cancer-with-repeated-resection-due-to-recurrence-in-the-pancreaticogastrostomy-site-after-pancreaticoduodenectomy
#3
Shohei Eto, Masashi Ishikawa, Michihito Asanoma, Yoshihiko Tashiro, Kazuo Matsuyama, Takehito Oshio
A 62-year-old man underwent endoscopic mucosal resection for early gastric cancer. The follow-up computed tomography revealed biliary dilatation. The tumor was located in the lower bile duct with biliary dilatation, and no evidence of metastasis in other organs was noted. The patient underwent subtotal stomach-preserving pancreatoduodenectomy with pancreaticogastrostomy and Billroth I anastomosis. At 13 months after the operation, gastrointestinal endoscopy revealed a tumor lesion in the pancreaticogastrostomy site...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29895797/peribiliary-glands-as-the-cellular-origin-of-biliary-tract-cancer
#4
REVIEW
Hayato Nakagawa, Yuki Hayata, Tomoharu Yamada, Satoshi Kawamura, Nobumi Suzuki, Kazuhiko Koike
The identification of the cellular origin of cancer is important for our understanding of the mechanisms regulating carcinogenesis, thus the cellular origin of cholangiocarcinoma (CCA) is a current topic of interest. Although CCA has been considered to originate from biliary epithelial cells, recent studies have suggested that multiple cell types can develop into CCA. With regard to the hilar and extrahepatic bile ducts, peribiliary glands (PBGs), a potential stem cell niche of biliary epithelial cells, have attracted attention as the cellular origin of biliary tract cancer...
June 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29893894/new-developments-in-systemic-therapy-for-advanced-biliary-tract-cancer
#5
Chigusa Morizane, Makoto Ueno, Masafumi Ikeda, Takuji Okusaka, Hiroshi Ishii, Junji Furuse
Biliary tract cancer, carcinoma of the extrahepatic bile ducts, carcinoma of the gall bladder, ampullary carcinoma and intrahepatic cholangiocarcinoma are often identified at an advanced stage and have poor prognoses. Although effective chemotherapy regimens are needed, their development remains unsatisfactory. From the results of a phase III clinical trial (ABC-02 trial), gemcitabine plus cisplatin is the standard first-line chemotherapeutic regimen for advanced biliary tract cancer. A phase III trial of gemcitabine plus cisplatin vs...
June 11, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29891522/clinical-impact-of-local-progression-in-pancreatic-cancer
#6
Nicholas Cardillo, Daniel M Seible, Katherine E Fero, Andrew R Bruggeman, Reith R Sarkar, Alexa Azuara, Daniel R Simpson, James D Murphy
Background: The high prevalence of distant metastatic disease among patients with pancreatic cancer often draws attention away from the local pancreatic tumor. This study aimed to define the complications and hospitalizations from local versus distant disease progression among a retrospective cohort of patients with pancreatic cancer. Methods: Records of 298 cases of pancreatic cancer treated at a single institution from 2004 through 2015 were retrospectively reviewed, and cancer-related symptoms and complications requiring hospitalization were recorded...
June 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29887343/incidence-of-cancer-other-than-gastric-cancer-in-pernicious-anaemia-a-systematic-review-with-meta-analysis
#7
REVIEW
Edith Lahner, Marina Capasso, Marilia Carabotti, Bruno Annibale
BACKGROUND: Pernicious anaemia (PA) is associated with increased gastric cancer risk, but the evidence is conflicting regarding the associated risk of other cancers. AIM: To systematically determine the incidence rates of gastro-intestinal cancers other than gastric cancers (GI-other-than-GC) and non-gastrointestinal cancers (non-GIC) in PA adults, globally and per tumour site, and the risk associated with PA for GI-other than GC and non-GIC. METHODS: Studies of PA patients reporting the incidence of GI-other-than-GCs and non-GICs were identified with MEDLINE (PubMed)-EMBASE (from first date available to April 2017)...
May 24, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29887260/a-systematic-review-of-the-anatomical-findings-of-multiple-gallbladders
#8
REVIEW
Benjamin Darnis, Kayvan Mohkam, François Cauchy, Jean-Baptiste Cazauran, Brigitte Bancel, Agnès Rode, Christian Ducerf, Mickaël Lesurtel, Jean-Yves Mabrut
BACKGROUND: Multiple gallbladders (MG) are a rare malformation, with no clear data on its clinical impact, therapeutic indications or risk for malignancy. METHODS: A systematic review of all published literature between 1990 and 2017 was performed using the PRISMA guidelines. RESULTS: Data of 181 patients extracted from 153 studies were reviewed. MG were diagnosed during the treatment of a gallstone-related disease in 83% of patients, of which 13% had previous cholecystectomy and had a recurrence of biliary stone disease...
June 7, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29886190/impact-of-diet-induced-obesity-on-the-mouse-brain-phosphoproteome
#9
Valentina Siino, Antonella Amato, Francesca Di Salvo, Gaetano Felice Caldara, Marcello Filogamo, Peter James, Sonya Vasto
Obesity is closely associated to several diseases such as type 2 diabetes, cardiovascular disease, hepatic steatosis, airway disease, neurodegeneration, biliary diseases and certain cancers. It is, therefore, of importance to assess the role of nutrition in disease prevention as well as its effect in the course of such pathologies. In the present study, we addressed the impact of the exposure to different obesogenic diets in the mice brains phosphoproteome. To analyze if the obesity could be able to modify the protein pattern expression of brain neurons, obesity was induced in two different groups of mice...
May 1, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29883461/the-different-course-of-alcoholic-and-idiopathic-chronic-pancreatitis-a-long-term-study-of-2-037-patients
#10
Lu Hao, Li-Sheng Wang, Yu Liu, Teng Wang, Hong-Lei Guo, Jun Pan, Dan Wang, Ya-Wei Bi, Jun-Tao Ji, Lei Xin, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Xiang-Peng Zeng, Wen-Bin Zou, Hui Chen, Ting Xie, Bai-Rong Li, Zhuan Liao, Zhi-Jie Cong, Zheng-Lei Xu, Zhao-Shen Li, Liang-Hao Hu
BACKGROUND: Chronic pancreatitis (CP) is a chronic inflammatory disease of the pancreas. This study aimed to compare the natural course of alcoholic chronic pancreatitis (ACP) and idiopathic chronic pancreatitis (ICP). METHODS: CP patients admitted to our center from January 2000 to December 2013 were enrolled. Characteristics were compared between ACP and ICP patients. Cumulative rates of diabetes mellitus (DM), steatorrhea, pancreatic stone, pancreatic pseudocyst, biliary stricture, and pancreatic cancer after the onset and the diagnosis of CP were calculated, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29872347/lifetime-risks-loss-of-life-expectancy-and-health-care-expenditures-for-19-types-of-cancer-in-taiwan
#11
Tzu-Yi Wu, Chia-Hua Chung, Chia-Ni Lin, Jing-Shiang Hwang, Jung-Der Wang
Background: The mortality rates for different cancers are no longer an efficient tool for making national policy. The purpose of this study were to quantify the lifetime risks, life expectancies (LEs) after diagnosis, expected years of life lost (EYLL), and lifetime health care expenditures for 19 major cancers in Taiwan. Methods: A total of 831,314 patients with 19 pathologically proven cancers were abstracted from the Taiwan Cancer Registry from 1998 to 2012. They were linked to the National Mortality Registry (1998-2014) and National Health Insurance reimbursement database (1998-2013) for survival and health care costs...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29871934/kras-and-tp53-mutations-cause-cholangiocyte-and-hepatocyte-derived-cholangiocarcinoma
#12
Margaret A Hill, William B Alexander, Bing Guo, Yasutaka Kato, Krushna Chandra Patra, Michael R O'Dell, Matthew N McCall, Christa L Whitney-Miller, Nabeel Bardeesy, Aram F Hezel
Intrahepatic cholangiocarcinoma (iCCA) is a primary liver cancer epidemiologically linked with liver injury which has poorly understood incipient stages and lacks early diagnostics and effective therapies. While iCCA is conventionally thought to arise from the biliary tract, studies have suggested that both hepatocytes and biliary cells (cholangiocytes) may give rise to iCCA. Consistent with the plasticity of these cell lineages, primary liver carcinomas exhibit a phenotypic range from hepatocellular carcinoma (HCC) to iCCA with intermediates along this spectrum...
June 5, 2018: Cancer Research
https://www.readbyqxmd.com/read/29869484/pet-imaging-in-adaptive-radiotherapy-of-gastrointestinal-tumours
#13
Philippe Bulens, Melissa Thomas, Christophe M Deroose, Karin Haustermans
Radiotherapy is the standard of care in the multimodality treatment of a variety of gastrointestinal (GI) tumours, such as oesophageal cancer, gastric cancer, rectal cancer and anal cancer. Additionally, radiotherapy has served as an alternative for surgery in patients with liver cancer, cancer of the biliary tract and pancreatic cancer. Positron-emission tomography (PET), generally in combination with computed tomography (CT), has an established role in the diagnosis, response assessment and (re-)staging of several GI tumours...
June 4, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29868636/safety-and-efficacy-of-self-expanding-metal-stents-for-biliary-drainage-in-patients-receiving-neoadjuvant-therapy-for-pancreatic-cancer
#14
Darren D Ballard, Syed Rahman, Brian Ginnebaugh, Abdul Khan, Kulwinder S Dua
Background and study aims:  Durable biliary drainage is essential during neoadjuvant therapy (NAT) in patients with pancreatic cancer who present with biliary obstruction. Plastic stents (PS) tend to occlude readily, resulting in delay/interruption of treatment. Our aim was to evaluate the safety and efficacy of self-expanding metal stents (SEMS) for biliary drainage in patients receiving NAT for pancreatic cancer. Patients and methods:  From 2009 to 2014, all consecutive patients with resectable pancreatic cancer at one tertiary center had SEMS placed for biliary drainage before NAT was started...
June 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29863171/precision-medicine-based-on-surgical-oncology-in-the-era-of-genome-scale-analysis-and-genome-editing-technology
#15
REVIEW
Shinji Tanaka
Accumulated evidence suggests that multiple molecular and cellular interactions promote cancer evolution in vivo. Surgical oncology is of growing significance to a comprehensive understanding of the malignant diseases for therapeutic application. We have analyzed more than 1000 clinical samples from surgically resected tissue to identify molecular biomarkers and therapeutic targets for advanced malignancies. Cancer stemness and mitotic instability were then determined as the essential predictors of aggressive phenotype with poor prognosis...
March 2018: Annals of gastroenterological surgery
https://www.readbyqxmd.com/read/29863155/clinical-implication-of-surgical-resection-for-recurrent-biliary-tract-cancer-does-it-work-or-not
#16
REVIEW
Masaru Miyazaki, Hiroaki Shimizu, Hideyuki Yoshitomi, Atsushi Kato, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Masayuki Ohtsuka
Although recent advances in imaging diagnosis, surgical techniques, and perioperative management can result in increased resectability and improved surgical outcomes, most resected patients still develop cancer recurrence. If patients develop cancer recurrence, their prognosis is very ominous. However, there have been some recent reports to show promising outcomes by aggressive surgical strategy in selected patients who developed cancer recurrence. Because there are various surgical procedures being selected at initial surgery in patients with biliary tract cancers, recurrent patterns after resection are very variable in each patient...
September 2017: Annals of gastroenterological surgery
https://www.readbyqxmd.com/read/29863124/occupational-cholangiocarcinoma-caused-by-exposure-to-1-2-dichloropropane-and-or-dichloromethane
#17
REVIEW
Shoji Kubo, Shigekazu Takemura, Shogo Tanaka, Hiroji Shinkawa, Masahiko Kinoshita, Genya Hamano, Tokuji Ito, Masaki Koda, Takanori Aota
A cluster of cholangiocarcinoma among printing company workers who were exposed to 1,2-dichloropropane and/or dichloromethane was classified by the Ministry of Health, Labour and Welfare of Japan on 1 October 2013 as "occupational cholangiocarcinoma". At the time of the diagnosis of cholangiocarcinoma, levels of γ-glutamyl transferase, and aspartate and alanine aminotransferases were elevated, and had been elevated in some patients several years prior to the diagnosis. Regional dilatation of intrahepatic bile ducts without tumor-induced obstruction was characteristic in diagnostic imaging...
March 2018: Annals of gastroenterological surgery
https://www.readbyqxmd.com/read/29862265/a-review-on-adducin-from-functional-to-pathological-mechanisms-future-direction-in-cancer
#18
REVIEW
Karrie Mei-Yee Kiang, Gilberto Ka-Kit Leung
Adducin (ADD) is a family of membrane skeleton proteins including ADD1, ADD2, and ADD3 that are encoded by distinct genes on different chromosomes. Adducin is primarily responsible for the assembly of spectrin-actin network that provides physical support to the plasma membrane and mediates signal transduction in various cellular physiological processes upon regulation by protein kinase C-dependent and calcium/calmodulin-dependent pathways. Abnormal phosphorylation, genetic variations, and alternative splicing of adducin may contribute to alterations in cellular functions involved in pathogenic processes...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29860941/internal-biliary-drainage-for-isolated-posterior-segmental-biliary-obstruction-a-case-report
#19
Hideki Izumi, Hisamichi Yoshii, Daiki Yokoyama, Shuji Uda, Rin Abe, Masaya Mukai, Eiji Nomura, Hiroyuki Ito, Takahiko Mine, Tomohiro Matsumoto, Terumitsu Hasebe, Hiroyasu Makuuchi
BACKGROUND: Biliary system anatomical abnormalities can be preoperatively detected on magnetic resonance imaging; therefore, some presume that the number of bile duct injuries should decline. However, once a bile duct injury occurs, repair may be difficult. There are various ways to repair bile duct injuries, but successful repair may be exceptionally difficult. CASE PRESENTATION: A 72-year-old Japanese man underwent a pancreaticoduodenectomy due to a diagnosis of middle bile duct cancer...
June 4, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29850295/microwave-thermal-ablation-in-an-unusual-case-of-malignant-and-locally-advanced-rare-tumor-of-pancreas-in-asa-iv-old-male-patient-and-literature-review
#20
Francesco D'Amico, Michele Finotti, Chiara Di Renzo, Alessio Pasquale, Alessandra Bertacco, Giorgio Caturegli, Gabriel E Gondolesi, Umberto Cillo
Pancreatic intraductal papillary-mucinous neoplasm is a rare primary neoplasm of unknown pathogenesis. This kind of tumor represents 0.2-2.7% of all pancreatic cancers and they may proceed to malignant lesions. In this study, we describe a case of pancreatic intraductal papillary-mucinous tumor (4.3 cm) with normal tumoral markers and nuclear atypia. We perform also a systematic review of the literature on MEDLINE and find only one relevant study that used microwave ablation for the palliative treatment of pancreatic tumor...
2018: Case Reports in Gastrointestinal Medicine
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