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https://www.readbyqxmd.com/read/28086990/the-efficacy-of-fluoropyrimidine-based-adjuvant-chemotherapy-on-biliary-tract-cancer-after-r0-resection
#1
Young Saing Kim, Chi-Young Jeong, Haa-Na Song, Tae Hyo Kim, Hong Jun Kim, Young-Joon Lee, Soon Chan Hong
BACKGROUND: The optimal treatment strategy for biliary tract cancer (BTC) after curative-intent resection remains controversial. The purpose of this study was to evaluate the efficacy of fluoropyrimidine-based adjuvant chemotherapy for BTC patients undergoing microscopically margin-negative (R0) resection. METHODS: We retrospectively analyzed the clinical data of BTC patients who underwent curative-intent R0 resection. Patients were eligible if they received either fluoropyrimidine-based adjuvant chemotherapy or observation after R0 resection...
January 13, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28081547/diagnosis-of-pancreaticobiliary-malignancy-by-detection-of-minichromosome-maintenance-protein-5-in-biliary-brush-cytology
#2
Margaret G Keane, Matthew T Huggett, Michael H Chapman, Gavin J Johnson, George J Webster, Douglas Thorburn, James Mackay, Stephen P Pereira
BACKGROUND: Biliary brush cytology is the standard method of evaluating biliary strictures, but is insensitive at detecting malignancy. In pancreaticobiliary cancer minichromosome maintenance replication proteins (MCM 2-7) are dysregulated in the biliary epithelium and MCM5 levels are elevated in bile samples. This study aimed to validate an immunocolorimetric ELISA assay for MCM5 as a pancreaticobiliary cancer biomarker in biliary brush samples. METHODS: Biliary brush specimens were collected prospectively at ERCP from patients with a biliary stricture...
January 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28081540/efficacy-of-fluoropyrimidine-based-chemotherapy-in-patients-with-advanced-biliary-tract-cancer-after-failure-of-gemcitabine-plus-cisplatin-retrospective-analysis-of-321-patients
#3
Bum Jun Kim, Changhoon Yoo, Kyu-Pyo Kim, Jaewon Hyung, Seong Joon Park, Baek-Yeol Ryoo, Heung-Moon Chang
BACKGROUND: We aimed to assess the efficacy of second-line fluoropyrimidine-based chemotherapy in patients with advanced biliary tract cancer (BTC) after failure of gemcitabine plus cisplatin (GEMCIS). METHODS: We retrospectively examined patients with histologically documented advanced BTC who received first-line GEMCIS between December 2010 and June 2015. Among 748 patients treated with first-line GEMCIS, 321 (43%) subsequently received fluoropyrimidine-based second-line systemic chemotherapy...
January 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28078124/advanced-biliary-tract-cancer-clinical-outcomes-with-abc-02-regimen-and-analysis-of-prognostic-factors-in-a-tertiary-care-center-in-the-united-states
#4
Rishi Agarwal, Arun Sendilnathan, Nabeela Iffat Siddiqi, Shuchi Gulati, Abhimanyu Ghose, Changchun Xie, Olugbenga Olanrele Olowokure
BACKGROUND: Gemcitabine plus cisplatin (GC) is currently the standard regimen for advanced biliary tract cancers (BTC) based on the outcomes in ABC-02 trial. Multiple factors can affect outcomes in these patients. This retrospective review evaluates the University of Cincinnati experience with GC in advanced intrahepatic (IHC)/extrahepatic cholangiocarcinoma (EHC) and gall bladder carcinoma (GBC). METHODS: In this study approved by University of Cincinnati IRB, retrospective analysis of advanced BTC patients seen between 01/2008 and 01/2015 was done...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28064203/predictive-factors-of-gastroduodenal-bleeding-after-postoperative-radiotherapy-in-biliary-tract-cancer
#5
Jieun Lee, Do Hoon Lim, Hee Chul Park, Jeong Il Yu, Dong Wook Choi, Seong Ho Choi, Jin Seok Heo
OBJECTIVE: To identify predictive factors for gastroduodenal bleeding after postoperative radiation therapy in patients with biliary tract cancer. METHODS: We identified 186 patients with biliary tract cancer who completed scheduled postoperative radiation therapy from March 2000 to August 2013. To isolate the effects of radiation on gastroduodenal bleeding, patients with pylorus-preserving pancreaticoduodenectomy, pylorus-resecting pancreaticoduodenectomy or Whipple surgery (n = 67) were excluded from this analysis...
January 6, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28063180/do-occupational-exposures-to-vinyl-chloride-cause-hepatocellular-carcinoma-and-cirrhosis
#6
Marcello Lotti
Controversy exists about the association between occupational exposures to vinyl chloride and hepatocellular carcinoma and cirrhosis. Two large multicentre mortality cohort studies, one American and another European, reported higher mortality for primary cancer of liver and biliary tract. However, the American study was not able to rule out misclassification, because based on death certificates and under the heading primary liver cancers, some angiosarcomas, the typical neoplasia associated with vinyl chloride, may have been included...
January 7, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28062877/-right-hepatectomy-in-block-with-hiliar-extra-hepatic-bile-duct-for-gallbladder-cancer-clinical-case
#7
Claudio Mengoa Quintanilla, Giovanni De la Cruz Robles, Sergio Puma Condori, Carol Durand Mendoza
Gallbladder cancer is the most common malignancy of the biliary tract. Usually seen in advanced stages. There are still many controversies about the type of curative surgical treatment for each stage of the disease. The only chance of long term survival for patients with advanced tumors is aggressive, large surgeries that implies multiorgan resection.We report the case of a patient with gallbladder cancer with jaundice at diagnosis, who underwent extended hepatectomy (segment IV B, segment I and extra hepatic hilar bile duct included)...
October 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28062868/temporal-trends-and-regional-variations-in-gastrointestinal-cancer-mortality-in-peru-2005-2014
#8
Akram Hernández-Vásquez, Guido Bendezú-Quispe, Diego Azañedo, Bertha Huarez, Belén Rodríguez-Lema
OBJECTIVE: To estimate and analyze the evolution of mortality rates of gastrointestinal (GI) cancer in Peru and its regions between 2005-2014. MATERIAL AND METHODS: We performed a nationwide secondary analysis of Peru's Health Ministry registry of deaths during the period 2005-2014, with a focus on regional differences. Deaths registered with codes C15 to C25 (malignant neoplasms of digestive organs) from the ICD-10 were included. Calculation of age-standarized mortality rates and years of life lost (YLL) due to GI cancer per 100,000 habitants were also performed...
October 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28059940/histologic-tumor-grade-and-preoperative-bilary-drainage-are-the-unique-independent-prognostic-factors-of-survival-in-pancreatic-ductal-adenocarcinoma-patients-after-pancreaticoduodenectomy
#9
Nicolás Macías, José M Sayagués, Carmen Esteban, Manuel Iglesias, Luís M González, Jose Quiñones-Sampedro, María L Gutiérrez, Luís A Corchete, Maria M Abad, Oscar Bengoechea, Luís Muñoz-Bellvis
BACKGROUND AND AIM: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer; most patients die during the first 6 months after diagnosis. With a 5% 5-year survival rate, is the fourth leading cause of cancer death in developed countries. In this regard, several clinical, histopathologic and biological characteristics of the disease favoring long-term survival after pancreaticoduodenectomy have been reported to be significant prognostic factors. Despite the availability of this information, there is no consensus about the different prognostic factors reported in the literature, probably due to variations in patient selection, methods, and sample size studied...
January 5, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28052308/prognostic-value-of-carbohydrate-antigen-19-9-in-patients-undergoing-resection-of-biliary-tract-cancer
#10
S Yamashita, G Passot, T A Aloia, Y S Chun, M Javle, J E Lee, J-N Vauthey, C Conrad
BACKGROUND: The clinical significance of abnormally high levels of carbohydrate antigen (CA) 19-9 after resection of biliary tract cancer (BTC) is not well established. The aim of this study was to determine the prognostic value of CA19-9 normalization in patients undergoing resection of BTC with curative intent. METHODS: Patients with BTC undergoing resection with curative intent (1996-2015) were divided into those with normal preoperative CA19-9 level (normal CA19-9 group), those with an abnormally high preoperative CA19-9 level (over 37 units/ml) and normal postoperative CA19-9 level (normalization group), and those with an abnormally high preoperative CA19-9 level and abnormally high postoperative CA19-9 level (non-normalization group)...
January 4, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28051219/incidental-gallbladder-cancer-diagnosed-on-cholecystectomy-specimens-a-study-of-30-cases
#11
Sana Ben Slama, Rym Ennaifer, Dhouha Bacha, Rached Bayar, Saadia Bouraoui, Lassaad Gharbi, Ahlem Lahmar
Background - The gallbladder cancer is a rare cancer with poor prognosis. The association with gallstone disease is the main risk factor of this cancer. Aim - Describe the demographics, clinic-pathologic and therapeutic management of incidentally gallbladder cancer diagnosed on cholecystectomy specimens. Methods - retrospective study including 30 cases of gallbladder cancer incidentally detected on cholecystectomy specimens. Results - The incidence of gallbladder cancer incidentally discovered was 0.83%. The sex ratio M/F was 0...
June 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28049283/application-of-photodynamic-therapy-in-gastrointestinal-disorders-an-outdated-or-re-emerging-technique
#12
REVIEW
Han Hee Lee, Myung-Gyu Choi, Tayyaba Hasan
Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient compliance due to the simplicity of the procedure; therefore, PDT is widely used as a palliative and salvage treatment in patients with various gastrointestinal malignancies. When used as a salvage treatment for locoregional failures after definitive chemoradiotherapy for esophageal cancer, favorable results have been reported...
January 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28046531/tu-h-206-08-quantitative-impact-of-biliary-stent-artefacts-on-mr-images
#13
O Gurney-Champion, T Bruins Slot, E Lens, A van der Horst, R Klaassen, H van Laarhoven, J van Hooft, A Nederveen, A Bel
PURPOSE: Biliary stents may cause artifacts in MR-images. These artifacts are caused by differences in susceptibility (artifact-1), eddy currents during read-out (artifact-2) and eddy currents due to the excitation pulse (artifact-3), which all are MRI sequence-dependent. In this study, we investigated and quantified the magnitude of these artifacts as a function of the distance from biliary stents, using a sequence-independent approach where possible. METHODS: Eight phantoms were made containing different commercial biliary stents made of nitinol, platinol, stainless steel or polyethylene...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043904/liver-cancer-cell-of-origin-molecular-class-and-effects-on-patient-prognosis
#14
REVIEW
Daniela Sia, Augusto Villanueva, Scott L Friedman, Josep M Llovet
Primary liver cancer is the second leading cause of cancer-related death worldwide and therefore a major public health challenge. We review hypotheses of the cell of origin of liver tumorigenesis, and clarify the classes of liver cancer, based on molecular features and how these affect patient prognosis. Primary liver cancer comprises hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), and other rare tumors, notably fibrolamellar carcinoma and hepatoblastoma. The molecular and clinical features of HCC vs iCCA are distinct, although they have overlapping risk factors and pathways of oncogenesis...
December 30, 2016: Gastroenterology
https://www.readbyqxmd.com/read/28043693/preoperative-biliary-stenting-versus-operation-first-in-jaundiced-patients-due-to-malignant-lesions-in-the-pancreatic-head-a-meta-analysis-of-current-literature
#15
REVIEW
Florian Scheufele, Stephan Schorn, Ihsan Ekin Demir, Mine Sargut, Elke Tieftrunk, Lenika Calavrezos, Carsten Jäger, Helmut Friess, Güralp Onur Ceyhan
BACKGROUND: Obstructive jaundice is a common presenting symptom among patients with pancreatic cancer. While benefits of preoperative biliary drainage have been suggested by previous studies, recent evidence has shown no significant improvements of preoperative biliary drainage on the postoperative outcome but rather an increase of complications. There is no clear consensus on whether to treat malignant obstructive jaundice with preoperative biliary drainage prior to operative intervention or to proceed directly to resection...
December 30, 2016: Surgery
https://www.readbyqxmd.com/read/28039901/living-donor-liver-transplantation-in-a-pediatric-patient-with-preexisting-yolk-sac-tumor
#16
Taiichi Wakiya, Yoshikazu Toyoki, Keinosuke Ishido, Daisuke Kudo, Norihisa Kimura, Shinji Tsutsumi, Tadashi Odagiri, Akiko Suto, Chiaki Uchida, Kenichi Hakamada
There is ongoing discussion regarding the indications and timing of LT for patients with a preexisting extrahepatic malignancy. We herein report a pediatric case that underwent LDLT after therapy for YST. The patient, a 13-year-old female with biliary atresia, had undergone portoenterostomy at 2 months of age. She developed a left ovarian tumor with a high serum alpha-fetoprotein concentration at 10 years of age. She underwent left oophorectomy and was diagnosed with ovarian YST (Stage I). After surgery, hepatopulmonary syndrome progressed gradually...
December 30, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/28039157/extracellular-vesicles-in-liver-diseases
#17
Sayantan Maji, Akiko Matsuda, Irene K Yan, Mansi Parasramka, Tushar Patel
Extracellular vesicles (EVs) are membrane-bound vesicles that are released by cells into their extracellular environment, have selective enrichment of specific proteins and RNA, and can mediate inter-cellular communication. In this review we highlight recent observations of the role of EVs in liver injury, viral hepatitis, alcoholic or non-alcoholic liver disease, biliary tract disease and liver cancers. Potential applications as markers of diseases or for therapeutic applications are outlined to emphasize the new opportunities that are arising from the study of EVs...
December 30, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28036262/interactive-role-of-diabetes-mellitus-and-female-sex-in-the-risk-of-cholangiocarcinoma-a-population-based-nested-case-control-study
#18
Yan-Jiun Huang, Alexander Th Wu, Hung-Yi Chiou, Ming-Tsang Chuang, Tzu-Ching Meng, Li-Nien Chien, Yun Yen
Diabetes mellitus (DM) has been associated with an increased risk of extrahepatic cholangiocarcinoma (ECC) and intrahepatic cholangiocarcinoma (ICC). However, the role of DM in a population with a lower incidence of ECC remains unclear. We investigated the role of DM and other risk factors for ECC and ICC by conducting a population-based, nested, case-control study in Taiwan, a region with a lower incidence but a higher proportion of ICC. We identified patients who received a diagnosis of cholangiocarcinoma (CC) from the Taiwan Cancer Registry between 2003 and 2009...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28030370/the-evolution-of-natural-history-of-primary-sclerosing-cholangitis
#19
Will R Takakura, James H Tabibian, Christopher L Bowlus
PURPOSE OF REVIEW: Primary sclerosing cholangitis (PSC) is a rare, idiopathic biliary disease often with an insidious onset, variable disease course, and premature death related to benign and malignant PSC-related sequelae. This review aims to discuss the epidemiology, clinical variants, and natural history of PSC, incorporating data from recent population-based studies. RECENT FINDINGS: PSC naturally leads to cirrhosis, cholangiocarcinoma, other hepatobiliary malignancies, dominant strictures, hepatic osteodystrophy, and bacterial cholangitis...
December 24, 2016: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28028375/response-of-brca1-mutated-gallbladder-cancer-to-olaparib-a-case-report
#20
Yuan Xie, Yan Jiang, Xiao-Bo Yang, An-Qiang Wang, Yong-Chang Zheng, Xue-Shuai Wan, Xin-Ting Sang, Kai Wang, Da-Dong Zhang, Jia-Jia Xu, Fu-Gen Li, Hai-Tao Zhao
Gallbladder cancer (GBC), although considered as a relatively rare malignancy, is the most common neoplasm of the biliary tract system. The late diagnosis and abysmal prognosis present challenges to treatment. The overall 5-year survival rate for metastatic GBC patients is extremely low. BRCA1 and BRCA2 are the breast cancer susceptibility genes and their mutation carriers are at a high risk for cancer development, both in men and women. Olaparib, an oral poly ADP-ribose polymerase inhibitor, has been approved by the Food and Drug Administration and the European Commission for the treatment of ovarian cancer with any BRCA1/2 mutations...
December 14, 2016: World Journal of Gastroenterology: WJG
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